DK0716600T3 - Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdomme - Google Patents
Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdommeInfo
- Publication number
- DK0716600T3 DK0716600T3 DK95923733T DK95923733T DK0716600T3 DK 0716600 T3 DK0716600 T3 DK 0716600T3 DK 95923733 T DK95923733 T DK 95923733T DK 95923733 T DK95923733 T DK 95923733T DK 0716600 T3 DK0716600 T3 DK 0716600T3
- Authority
- DK
- Denmark
- Prior art keywords
- treatment
- acid derivatives
- topically administrable
- preparations containing
- eye diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
- C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/254,090 US5475034A (en) | 1994-06-06 | 1994-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
PCT/US1995/007187 WO1995033457A1 (en) | 1994-06-06 | 1995-06-06 | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0716600T3 true DK0716600T3 (da) | 2002-06-24 |
Family
ID=22962892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95923733T DK0716600T3 (da) | 1994-06-06 | 1995-06-06 | Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdomme |
Country Status (15)
Country | Link |
---|---|
US (1) | US5475034A (zh) |
EP (1) | EP0716600B1 (zh) |
JP (1) | JP2866744B2 (zh) |
KR (1) | KR100194242B1 (zh) |
CN (1) | CN1088992C (zh) |
AT (1) | ATE215366T1 (zh) |
CA (1) | CA2167524C (zh) |
DE (1) | DE69526183T2 (zh) |
DK (1) | DK0716600T3 (zh) |
ES (1) | ES2171543T3 (zh) |
HK (1) | HK1012554A1 (zh) |
MX (1) | MX9600487A (zh) |
PT (1) | PT716600E (zh) |
TW (1) | TW425382B (zh) |
WO (1) | WO1995033457A1 (zh) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
US20030086899A1 (en) * | 2000-03-14 | 2003-05-08 | Jafari Masoud R. | Chondroitin sulfate containing viscoelastics for use in treating joints |
AR030346A1 (es) | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
AU2002247284A1 (en) | 2001-04-02 | 2002-10-15 | Alcon, Inc. | Method of treating ocular inflammatory and angiogenesis-related disorders using an amide derivative of flubiprofen or ketorolac |
US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
WO2003092669A2 (en) * | 2002-05-03 | 2003-11-13 | Alcon, Inc. | Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac |
WO2004064828A1 (ja) * | 2003-01-21 | 2004-08-05 | Senju Pharmaceutical Co., Ltd. | 2−アミノ−3−(4−ブロモベンゾイル)フェニル酢酸含有水性液剤 |
US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
EP1633339A4 (en) * | 2003-06-13 | 2009-06-03 | Alcon Inc | FORMULATIONS OF NON-TEROIDAL ANTI-RHEUMATICS FOR THE TREATMENT OF PATHOLOGICAL OCCULAR ANGIOGENESIS |
PL1683526T3 (pl) * | 2003-11-14 | 2012-09-28 | Senju Pharma Co | Preparat wodnego roztworu zawierający antybiotyk aminoglikozydowy i bromfenak |
US8748402B2 (en) | 2004-06-07 | 2014-06-10 | Bausch & Lomb Pharma Holdings Corp. | Ophthalmic formulations and uses thereof |
US8372814B2 (en) | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
TWI358290B (en) | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
CA2607014A1 (en) * | 2005-05-10 | 2006-11-16 | Alcon, Inc. | Suspension formulations of nepafenac and other ophthalmic drugs for topical treatment of ophthalmic disorders |
ES2322200T3 (es) * | 2005-05-10 | 2009-06-17 | Alcon, Inc. | Formulaciones en suspension que comprenden un principio activo, un tensioactivo poloxamero o meroxapol y un glicol, su uso para la fabricacion de un medicamento para tratar trastornos oftalmicos. |
US20100130580A1 (en) * | 2006-01-25 | 2010-05-27 | Aciex Therapeutics, Inc. | Formulations and Methods for Treating Dry Eye |
EP1981491A4 (en) * | 2006-01-25 | 2009-09-23 | Aciex Inc | COMPOSITIONS AND METHODS FOR TREATING OPHTHALMIC DROUGHT |
TW200812575A (en) * | 2006-04-28 | 2008-03-16 | Alcon Inc | Formulations containing amide derivatives of carboxylic acid NSAIDs for topical administration to the eye |
US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
WO2008080110A1 (en) * | 2006-12-21 | 2008-07-03 | Alcon, Inc. | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
UY31058A1 (es) * | 2007-05-01 | 2008-10-31 | Alcon Res Ltd | Formulaciones de aminoacido n-halogenado con compuestos antiinflamatorios |
JP2010528014A (ja) * | 2007-05-24 | 2010-08-19 | アーシエックス セラピューティックス, インコーポレイテッド | ドライアイを処置するための処方物および方法 |
RU2014151622A (ru) | 2007-10-05 | 2015-08-20 | Акусела Инк. | Композиции и способы лечения нейродегенеративных заболеваний |
US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
US20090239909A1 (en) * | 2008-03-24 | 2009-09-24 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with lactams |
CN102438979A (zh) * | 2009-03-12 | 2012-05-02 | 麦迪凯姆股份公司 | 苯甲酰基苯乙酰胺衍生物的新型晶体 |
ES2897527T3 (es) | 2009-07-02 | 2022-03-01 | Acucela Inc | Farmacología de moduladores del ciclo visual |
AU2010326099B2 (en) * | 2009-12-03 | 2013-03-07 | Novartis Ag | Carboxyvinyl polymer-container nanoparticle suspensions |
US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1226344A (zh) * | 1967-07-31 | 1971-03-24 | ||
CH577461A5 (zh) * | 1975-08-13 | 1976-07-15 | Robins Co Inc A H | |
US4318949A (en) * | 1976-09-16 | 1982-03-09 | Toray Industries, Inc. | Composite nap sheet and process for preparing the same |
US4313949A (en) * | 1979-09-26 | 1982-02-02 | A. H. Robins Company, Inc. | Method of producing an inhibitory effect on blood platelet aggregation |
US4254146A (en) * | 1979-10-18 | 1981-03-03 | A. H. Robins Company, Inc. | 3-Benzoyl-2-nitrophenylacetic acids, metal salts, amides and esters |
IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
DE3026402A1 (de) * | 1980-07-11 | 1982-02-04 | Syntex Corp., Palo Alto, Calif. | Die verwendung analgetischer und nicht-hormonaler, entzuendungshemmender mittel bei der behandlung von mikrovaskulaeren erkrankungen |
US4503073A (en) * | 1981-01-07 | 1985-03-05 | A. H. Robins Company, Incorporated | 2-Amino-3-(alkylthiobenzoyl)-phenylacetic acids |
IL64724A0 (en) * | 1981-02-17 | 1982-03-31 | Robins Co Inc A H | 2-amino-3-(halobenzoyl)-methylphenylacetic acids and esters and salts thereof and pharmaceutical compositions containing them |
US4568695A (en) * | 1983-12-07 | 1986-02-04 | A. H. Robins Company, Incorporated | 2-Amino-3-benzoyl-phenethylalcohols and intermediates therefor |
US4851443A (en) * | 1985-03-14 | 1989-07-25 | Smith Kline Dauelsberg, Gmbh | Carboxylic acid amides, compositions and medical use thereof |
DE3668450D1 (de) * | 1985-03-14 | 1990-03-01 | Smithkline Dauelsberg | 5-aminosalicylsaeurederivate von nicht-steroidalen entzuendungshemmenden sauren. |
US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
CA1325382C (en) * | 1988-01-27 | 1993-12-21 | Takahiro Ogawa | Locally administrable therapeutic composition for inflammatory disease |
-
1994
- 1994-06-06 US US08/254,090 patent/US5475034A/en not_active Expired - Lifetime
-
1995
- 1995-06-06 JP JP8501284A patent/JP2866744B2/ja not_active Expired - Lifetime
- 1995-06-06 DE DE69526183T patent/DE69526183T2/de not_active Expired - Lifetime
- 1995-06-06 CN CN95190521A patent/CN1088992C/zh not_active Expired - Lifetime
- 1995-06-06 TW TW084105686A patent/TW425382B/zh not_active IP Right Cessation
- 1995-06-06 PT PT95923733T patent/PT716600E/pt unknown
- 1995-06-06 CA CA002167524A patent/CA2167524C/en not_active Expired - Lifetime
- 1995-06-06 WO PCT/US1995/007187 patent/WO1995033457A1/en active IP Right Grant
- 1995-06-06 DK DK95923733T patent/DK0716600T3/da active
- 1995-06-06 MX MX9600487A patent/MX9600487A/es unknown
- 1995-06-06 EP EP95923733A patent/EP0716600B1/en not_active Expired - Lifetime
- 1995-06-06 ES ES95923733T patent/ES2171543T3/es not_active Expired - Lifetime
- 1995-06-06 AT AT95923733T patent/ATE215366T1/de active
- 1995-06-06 KR KR1019960700563A patent/KR100194242B1/ko not_active IP Right Cessation
-
1998
- 1998-12-17 HK HK98113825A patent/HK1012554A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TW425382B (en) | 2001-03-11 |
AU689277B2 (en) | 1998-03-26 |
HK1012554A1 (en) | 1999-08-06 |
DE69526183T2 (de) | 2002-09-26 |
EP0716600A1 (en) | 1996-06-19 |
CN1129397A (zh) | 1996-08-21 |
JP2866744B2 (ja) | 1999-03-08 |
ES2171543T3 (es) | 2002-09-16 |
CN1088992C (zh) | 2002-08-14 |
DE69526183D1 (de) | 2002-05-08 |
ATE215366T1 (de) | 2002-04-15 |
CA2167524C (en) | 2002-08-13 |
CA2167524A1 (en) | 1995-12-14 |
KR100194242B1 (ko) | 1999-06-15 |
US5475034A (en) | 1995-12-12 |
MX9600487A (es) | 1997-06-28 |
WO1995033457A1 (en) | 1995-12-14 |
JPH08510479A (ja) | 1996-11-05 |
AU2818495A (en) | 1996-01-04 |
KR960703580A (ko) | 1996-08-31 |
EP0716600B1 (en) | 2002-04-03 |
PT716600E (pt) | 2002-09-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0716600T3 (da) | Topisk indgivelsesbare præparater indeholdende 3-benzoylphenyleddikesyrederivater til behandling af inflammatoriske øjensygdomme | |
DE69625691D1 (de) | Verabreichung von peptidylheterocyclen zur behandlung von thrombin in zusammenhang stehenden krankheiten | |
EA200200262A1 (ru) | Пиперазиновые производные и их применение в качестве противовоспалительных агентов | |
TW262461B (zh) | ||
NO973384L (no) | Celle-adhesjonsinhibitorer | |
NZ331163A (en) | Composition comprising interleukin-1 inhibitor and hydrogel ester (hyaluronan) for treating inflammatory diseases | |
SE7903186L (sv) | Cerebralverksamt medel | |
ATE202706T1 (de) | Verwendung von 9-deoxyprostaglandinderivaten zur behandlung von glaukom | |
DE69733132D1 (de) | Verwendung von antioxidantien zur behandlung cholestatischer lebererkrankungen | |
MC2078A1 (fr) | Emploi d'alezastine comme matiere active contre le psoriasis et des maladies inflammatoires | |
PT1039895E (pt) | Utilizacao de acidos 3-benzoilfenilaceticos respectivos esteres ou amidas para o tratamento do glaucoma glc1a | |
ATE183393T1 (de) | Kombinationspräparat, enthaltend 5-methylisoxazol-4-carbonsäure-(4-trifluormethy )-anilid und n-(4- trifluormethylphenyl)-2-cyan-3- hydroxycrotonsäureamid | |
TR199802060T2 (xx) | Aminoisokinolinler ve aminopiridin t�revlerinin iltihap �nleyiciler olarak kullan�m�. | |
EA199700380A1 (ru) | Бициклические ароматические соединения, фармацевтическая и косметическая композиции на их основе и применение косметической композиции | |
EA200000741A1 (ru) | Новые производные дигидроксигексановой кислоты | |
IE802589L (en) | Anti-inflammatory pharmaceutical composition containing¹rosmarinic acid | |
NZ330244A (en) | Isoxazole derivatives useful in the treatment of inflammatory diseases | |
DK0841933T3 (da) | Præparater med Bowman-Birk-inhibitor til behandling af inflammatoriske sygdomme | |
TR199900725T2 (xx) | Hidroksamik asit t�revleri | |
AU2068895A (en) | Dl- di- or tri-hydroxyphenylglycine alkyl esters for the treatment of inflammatory and allergic conditions | |
ATE97812T1 (de) | Therapeutische verwendung des isopropylesterderivates von monosialogangliosiden bei erkrankungen des nervensystems, begleitet von entzuendungen. | |
CA2073673A1 (en) | Esters of 2-arylmethyl-1-naphthol derivatives as 5-lipoxygenase inhibitors | |
IT8024347A0 (it) | L'applicazione di 4-arilchinazolin-2(1h)-oni per il trattamento delle malattie autoimmuni dei tessuti connettivi. |