DK0707481T3 - L-2',3'-Dideoxy-nucleosidanaloge som anti-hepatitis B (HBV)- og anti-HIV-midler - Google Patents

L-2',3'-Dideoxy-nucleosidanaloge som anti-hepatitis B (HBV)- og anti-HIV-midler

Info

Publication number
DK0707481T3
DK0707481T3 DK94919207T DK94919207T DK0707481T3 DK 0707481 T3 DK0707481 T3 DK 0707481T3 DK 94919207 T DK94919207 T DK 94919207T DK 94919207 T DK94919207 T DK 94919207T DK 0707481 T3 DK0707481 T3 DK 0707481T3
Authority
DK
Denmark
Prior art keywords
hbv
dideoxy
present
hepatitis
replication
Prior art date
Application number
DK94919207T
Other languages
Danish (da)
English (en)
Inventor
Yung-Chi Cheng
Tai-Shun Lin
Original Assignee
Univ Yale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Yale filed Critical Univ Yale
Application granted granted Critical
Publication of DK0707481T3 publication Critical patent/DK0707481T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94919207T 1993-05-25 1994-05-23 L-2',3'-Dideoxy-nucleosidanaloge som anti-hepatitis B (HBV)- og anti-HIV-midler DK0707481T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6729993A 1993-05-25 1993-05-25
US08/098,650 US5627160A (en) 1993-05-25 1993-07-28 L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
PCT/US1994/005790 WO1994027616A1 (fr) 1993-05-25 1994-05-23 Analogues de l-2', 3'-didesoxy nucleosides utilises comme agents anti-hepatite b et anti-vih

Publications (1)

Publication Number Publication Date
DK0707481T3 true DK0707481T3 (da) 2000-10-30

Family

ID=26747712

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94919207T DK0707481T3 (da) 1993-05-25 1994-05-23 L-2',3'-Dideoxy-nucleosidanaloge som anti-hepatitis B (HBV)- og anti-HIV-midler

Country Status (14)

Country Link
US (1) US5627160A (fr)
EP (1) EP0707481B1 (fr)
JP (2) JPH08510747A (fr)
KR (1) KR100279953B1 (fr)
CN (1) CN1076021C (fr)
AT (1) ATE195423T1 (fr)
CA (1) CA2163520C (fr)
DE (1) DE69425574T2 (fr)
DK (1) DK0707481T3 (fr)
ES (1) ES2150993T3 (fr)
GR (1) GR3034379T3 (fr)
HK (1) HK1013257A1 (fr)
PT (1) PT707481E (fr)
WO (1) WO1994027616A1 (fr)

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US5827727A (en) * 1990-02-01 1998-10-27 Emory University Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US5444063A (en) * 1990-12-05 1995-08-22 Emory University Enantiomerically pure β-D-dioxolane nucleosides with selective anti-Hepatitis B virus activity
US5817667A (en) * 1991-04-17 1998-10-06 University Of Georgia Research Foudation Compounds and methods for the treatment of cancer
JPH09504785A (ja) * 1993-09-10 1997-05-13 エモリー、ユニバーシティー 抗ｂ型肝炎ウイルス活性を有するヌクレオシド
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US5587362A (en) * 1994-01-28 1996-12-24 Univ. Of Ga Research Foundation L-nucleosides
US5512431A (en) * 1994-06-29 1996-04-30 Darwin Molecular Corporation Methods of screening for nucleoside analogs that are incorporated by HIV reverse transcriptase and cause incorrect base pairing
IL115156A (en) * 1994-09-06 2000-07-16 Univ Georgia Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines
US5559101A (en) * 1994-10-24 1996-09-24 Genencor International, Inc. L-ribofuranosyl nucleosides
US5703058A (en) * 1995-01-27 1997-12-30 Emory University Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent
US6391859B1 (en) 1995-01-27 2002-05-21 Emory University [5-Carboxamido or 5-fluoro]-[2′,3′-unsaturated or 3′-modified]-pyrimidine nucleosides
US5808040A (en) * 1995-01-30 1998-09-15 Yale University L-nucleosides incorporated into polymeric structure for stabilization of oligonucleotides
WO1996028162A1 (fr) * 1995-03-14 1996-09-19 University Of Medicine & Dentistry Of New Jersey Nouvelle composition de medicaments pour le traitement d'affections virales
US5869461A (en) * 1995-03-16 1999-02-09 Yale University Reducing toxicity of L-nucleosides with D-nucleosides
EP1655033A1 (fr) * 1995-06-07 2006-05-10 Emory University Nucléosites ayant une activité anti-virus de l'hépatite B
US5753789A (en) * 1996-07-26 1998-05-19 Yale University Oligonucleotides containing L-nucleosides
EP1132393B1 (fr) * 1996-10-16 2003-04-09 ICN Pharmaceuticals, Inc. L-Ribavirine et son utilisation
PT1027359E (pt) * 1996-10-16 2003-09-30 Ribapharm Inc L-nucleosideos monociclicos analogos e suas utilizacoes
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
ATE271063T1 (de) * 1996-10-16 2004-07-15 Icn Pharmaceuticals Purin-l-nukleoside, deren analoga und verwendungen
US6090602A (en) 1998-02-18 2000-07-18 Promelas Research Corporation Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
BRPI9912896B8 (pt) * 1998-08-10 2021-05-25 Centre Nat Rech Scient ß-l-2' -desoxinucleosídeos para tratamento de hepatite b
US7635690B2 (en) 1999-01-22 2009-12-22 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US7115584B2 (en) * 1999-01-22 2006-10-03 Emory University HIV-1 mutations selected for by β-2′,3′-didehydro-2′,3′-dideoxy-5-fluorocytidine
US6525191B1 (en) * 1999-05-11 2003-02-25 Kanda S. Ramasamy Conformationally constrained L-nucleosides
US6436948B1 (en) 2000-03-03 2002-08-20 University Of Georgia Research Foundation Inc. Method for the treatment of psoriasis and genital warts
US6914052B2 (en) 2001-03-15 2005-07-05 The Trustees Of Boston College Selective anti-viral nucleoside chain terminators
RU2310661C2 (ru) * 2002-04-12 2007-11-20 Акиллион Фармасьютикалз, Инк. Способ синтеза бета-l-5-фтор-2', 3'-дидезокси-2', 3'-дидегидроцитидина (бета-l-fd4c)
US20040067877A1 (en) * 2002-08-01 2004-04-08 Schinazi Raymond F. 2', 3'-Dideoxynucleoside analogues for the treatment or prevention of Flaviviridae infections
WO2005026186A1 (fr) * 2003-09-12 2005-03-24 Max-Delbrück-Centrum für Molekulare Medizin Nucleosides β-l et leur utilisation comme agents pharmaceutiques pour traiter des affections virales
CA2584670A1 (fr) 2004-10-19 2006-04-27 Achillion Pharmaceuticals, Inc. Polytherapie permettant de traiter des infections virales
GB0513835D0 (en) * 2005-07-07 2005-08-10 Medivir Ab HIV inhibitors
EP2514750B1 (fr) 2007-06-18 2013-11-20 Sunshine Lake Pharma Co., Ltd Thiazolyl-dihydropyrimidines a substitution bromo-phenyle
US8816074B2 (en) * 2009-11-16 2014-08-26 University of Georgia Foundation, Inc. 2′-fluoro-6′-methylene carbocyclic nucleosides and methods of treating viral infections
KR20120114309A (ko) * 2009-12-17 2012-10-16 노바덱스 파마슈티컬즈 에이비 신규한 3''-데옥시-3''-메틸리덴-베타-ｌ-뉴클레오사이드
CN102234280B (zh) * 2010-04-26 2014-01-08 北京大学 D,l-鸟嘌呤核苷类似物及其制备方法和应用
US10933067B2 (en) 2016-11-16 2021-03-02 National Center For Global Health And Medicine Nucleoside derivative having physiological activity such as antiviral activity
KR102077833B1 (ko) 2018-12-10 2020-02-14 류형준 기능성 식품조성물

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AU570853B2 (en) * 1985-08-26 1988-03-24 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Inhibition of infectivity and cytopathic effect of htlv-111/ lav by purine bases
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Also Published As

Publication number Publication date
CN1076021C (zh) 2001-12-12
EP0707481A1 (fr) 1996-04-24
CA2163520C (fr) 2006-01-10
EP0707481A4 (fr) 1996-05-29
KR100279953B1 (ko) 2001-02-01
WO1994027616A1 (fr) 1994-12-08
JP2004244422A (ja) 2004-09-02
HK1013257A1 (en) 1999-10-22
CA2163520A1 (fr) 1994-12-08
ES2150993T3 (es) 2000-12-16
ATE195423T1 (de) 2000-09-15
EP0707481B1 (fr) 2000-08-16
JPH08510747A (ja) 1996-11-12
DE69425574D1 (en) 2000-09-21
CN1100303A (zh) 1995-03-22
US5627160A (en) 1997-05-06
PT707481E (pt) 2001-02-28
AU693795B2 (en) 1998-07-09
AU7043094A (en) 1994-12-20
GR3034379T3 (en) 2000-12-29
DE69425574T2 (de) 2001-01-04

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