DK0700514T3 - Apparat og fremgangsmåder til homogene multianalyt-fluoroimmunoassays - Google Patents

Apparat og fremgangsmåder til homogene multianalyt-fluoroimmunoassays

Info

Publication number
DK0700514T3
DK0700514T3 DK94923161T DK94923161T DK0700514T3 DK 0700514 T3 DK0700514 T3 DK 0700514T3 DK 94923161 T DK94923161 T DK 94923161T DK 94923161 T DK94923161 T DK 94923161T DK 0700514 T3 DK0700514 T3 DK 0700514T3
Authority
DK
Denmark
Prior art keywords
analyte
patches
capture molecules
specific
methods
Prior art date
Application number
DK94923161T
Other languages
Danish (da)
English (en)
Inventor
Douglas A Christensen
James N Herron
Hsu-Kun Wang
Karin D Caldwell
Vera Janatova
Shao-Chie Huang
Original Assignee
Univ Utah Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/064,608 external-priority patent/US5512492A/en
Application filed by Univ Utah Res Found filed Critical Univ Utah Res Found
Application granted granted Critical
Publication of DK0700514T3 publication Critical patent/DK0700514T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plasma & Fusion (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK94923161T 1993-05-18 1994-05-18 Apparat og fremgangsmåder til homogene multianalyt-fluoroimmunoassays DK0700514T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/064,608 US5512492A (en) 1993-05-18 1993-05-18 Waveguide immunosensor with coating chemistry providing enhanced sensitivity
US7157993A 1993-06-02 1993-06-02
PCT/US1994/005567 WO1994027137A2 (en) 1993-05-18 1994-05-18 Apparatus and methods for multianalyte homogeneous fluoroimmunoassays

Publications (1)

Publication Number Publication Date
DK0700514T3 true DK0700514T3 (da) 2002-03-25

Family

ID=26744692

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94923161T DK0700514T3 (da) 1993-05-18 1994-05-18 Apparat og fremgangsmåder til homogene multianalyt-fluoroimmunoassays

Country Status (9)

Country Link
EP (1) EP0700514B1 (ja)
JP (1) JP3426602B2 (ja)
AT (1) ATE209782T1 (ja)
AU (1) AU704947B2 (ja)
CA (1) CA2162996C (ja)
DE (1) DE69429262T2 (ja)
DK (1) DK0700514T3 (ja)
ES (1) ES2169079T3 (ja)
WO (1) WO1994027137A2 (ja)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7081226B1 (en) 1996-06-04 2006-07-25 University Of Utah Research Foundation System and method for fluorescence monitoring
US7273749B1 (en) 1990-06-04 2007-09-25 University Of Utah Research Foundation Container for carrying out and monitoring biological processes
US5935522A (en) * 1990-06-04 1999-08-10 University Of Utah Research Foundation On-line DNA analysis system with rapid thermal cycling
US6632613B1 (en) 1993-06-02 2003-10-14 University Of Utah Research Foundation Compositions and kits for fluorescence polarization assay of large molecules
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
AT403745B (de) * 1996-02-29 1998-05-25 Avl Verbrennungskraft Messtech Messanordnung mit einem für anregungs- und messstrahlung transparentem trägerelement
WO1997032212A1 (en) * 1996-03-01 1997-09-04 Beckman Instruments, Inc. System for simultaneously conducting multiple ligand binding assays
US6356676B1 (en) 1996-03-19 2002-03-12 University Of Utah Research Foundation Lens and associatable flow cell
EP0888546A1 (en) * 1996-03-19 1999-01-07 University Of Utah Research Foundation Oscillation apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
EP0890093A4 (en) * 1996-03-19 2000-03-15 Univ Utah Res Found SYSTEM FOR DETERMINING THE CONCENTRATION OF A SAMPLE TO BE ANALYZED
US6611634B2 (en) 1996-03-19 2003-08-26 University Of Utah Research Foundation Lens and associatable flow cell
JP3886153B2 (ja) 1996-03-19 2007-02-28 ユニバーシティー オブ ユタ リサーチ ファンデーション レンズおよび連結可能なフローセル
EP0990135A4 (en) * 1996-04-30 2000-04-26 Metrika Inc METHOD AND DEVICE FOR MEASURING REFLECTED OPTICAL RADIATION
JP4281877B2 (ja) * 1996-06-04 2009-06-17 ユニバーシティ オブ ユタ リサーチ ファウンデーション 生物学的プロセスを実行し且つモニタリングするためのシステムと方法
DE19628002C1 (de) * 1996-07-11 1997-12-18 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
DE19651935A1 (de) * 1996-12-14 1998-06-18 Ruckstuhl Thomas Detektionssystem für den optischen Nachweis von Molekülen
US5812272A (en) * 1997-01-30 1998-09-22 Hewlett-Packard Company Apparatus and method with tiled light source array for integrated assay sensing
US6686208B2 (en) 1997-03-18 2004-02-03 Institut Fur Chemo- Und Biosensorik Munster E.V. Device and method for carrying out fluoresence immunotests
DE19711281C1 (de) * 1997-03-18 1998-04-16 Inst Chemo Biosensorik Vorrichtung und Verfahren zur Durchführung von Fluoreszenzimmunotests
CZ297165B6 (cs) * 1997-04-21 2006-09-13 Randox Laboratories Ltd. A British Company Of Ardmore Zpusob výroby zarízení s pevnou fází k provádení multianalytních rozboru
ES2353840T3 (es) 1997-04-21 2011-03-07 California Institute Of Technology Recubrimientos tisulares poliméricos multifuncionales.
DE19725050C2 (de) * 1997-06-13 1999-06-24 Fraunhofer Ges Forschung Anordnung zur Detektion biochemischer oder chemischer Substanzen mittels Fluoreszenzlichtanregung und Verfahren zu deren Herstellung
DE19736641A1 (de) * 1997-08-22 1999-03-11 Michael G Dr Weller Verfahren und Vorrichtung zur parallelen Messung von mehreren Analyten in komplexen Mischungen
DE19748489A1 (de) * 1997-11-03 1999-05-06 Roche Diagnostics Gmbh Polyethylenglykol-derivatisierte Biomoleküle und deren Verwendung in heterogenen Nachweisverfahren
JPH11183358A (ja) * 1997-12-25 1999-07-09 Kowa Co 蛍光粒子撮像用容器
US6200814B1 (en) 1998-01-20 2001-03-13 Biacore Ab Method and device for laminar flow on a sensing surface
DE19815109A1 (de) * 1998-04-03 1999-10-07 Bodenseewerk Perkin Elmer Co Vorrichtung zum Nachweis eines Fluoreszenzfarbstoffs
GB9903283D0 (en) * 1998-06-01 1999-04-07 Farfield Sensors Ltd Device
AU769571B2 (en) 1999-04-28 2004-01-29 Universitat Zurich Polyionic coatings in analytic and sensor devices
US6127129A (en) * 1999-05-04 2000-10-03 Wisconsin Alumni Research Foundation Process to create biomolecule and/or cellular arrays on metal surfaces and product produced thereby
US6701032B1 (en) 1999-05-27 2004-03-02 Farfield Sensors Limited Device for housing a planar optical component
EP1983331B1 (en) 1999-05-28 2011-07-13 Yokogawa Electric Corporation Optical system for reading a biochip
WO2001001112A1 (en) * 1999-06-26 2001-01-04 Packard Instrument Company, Inc. Microplate reader
WO2001013096A1 (de) * 1999-08-13 2001-02-22 Zeptosens Ag Vorrichtung und verfahren zur multianalytbestimmung
DE50010710D1 (de) † 1999-08-20 2005-08-18 Diagnostische Forsch Stiftung Verfahren zur bestimmung von substanzen mittels der evaneszenzfeldmethode
WO2001043875A1 (de) 1999-12-17 2001-06-21 Zeptosens Ag Flusszellenanordnung und deren verwendung zur multianalytbestimmung
DE10012793C2 (de) * 2000-03-13 2002-01-24 Fraunhofer Ges Forschung Sensorelement zur optischen Detektion von chemischen oder biochemischen Analyten
DE50115363D1 (de) 2000-09-04 2010-04-08 Bayer Technology Services Gmbh System und verfahren zur multianalytbestimmung
DE10152690A1 (de) * 2001-10-19 2003-05-08 Genescan Europ Ag Durchflussreaktionskammer für Sensorchips
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
DE60211685T2 (de) * 2002-08-02 2007-05-10 Sony Deutschland Gmbh Verfahren zur Bindung hydophiler Substanzen an hydrophile Makromoleküle und Immobilisierung derselben auf hydrophoben Oberflächen
DE10319712A1 (de) * 2003-05-02 2004-11-25 Sirs-Lab Gmbh Vorrichtung zur Aufnahme von Proben bei Vervielfältigungsreaktionen
DE10336849A1 (de) * 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
JP4799557B2 (ja) * 2004-06-09 2011-10-26 ベクトン・ディキンソン・アンド・カンパニー 多検体センサー
DE102004039564B4 (de) * 2004-08-13 2006-06-29 Institut für Lasertechnologien in der Medizin und Meßtechnik an der Universität Ulm Vorrichtung zum optischen Screening von Oberflächen biologischer Proben in zweidimensionaler Anordnung
JP4460405B2 (ja) * 2004-09-21 2010-05-12 富士フイルム株式会社 全反射減衰を利用した測定方法及び装置並びに固定装置
ATE412170T1 (de) * 2004-12-17 2008-11-15 Koninkl Philips Electronics Nv Mehrpunktuntersuchungsgerät
BRPI0519976A2 (pt) * 2005-02-10 2009-04-07 Commissariat Energie Atomique método para a ligação fotoquìmica de biomoléculas a um substrato
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
DE102005048188B4 (de) * 2005-10-02 2007-10-25 Technische Universität Dresden Verwendung einer Einrichtung zur Fluoreszenzphotometrie von in Durchflussküvetten befindlichen Flüssigkeiten mit Markern
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
ES2537564T3 (es) * 2006-11-01 2015-06-09 Beckman Coulter, Inc. Superficies de unión para ensayos de afinidad
DE102007033124B4 (de) 2007-07-16 2012-12-06 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Vorrichtung zur optischen Detektion von Substanzen in einem flüssigen oder gasförmigen Medium
EP2179261B1 (en) 2007-07-23 2021-09-15 Sartorius BioAnalytical Instruments, Inc Fluidic configuration for flow injection analysis system
GB2461026B (en) 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US20100184616A1 (en) * 2009-01-20 2010-07-22 Bio-Rad Laboratories, Inc. Spatially controlled illumination of biological sample array through wedge-shaped support
US8331751B2 (en) 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
US8300993B2 (en) * 2009-03-02 2012-10-30 Mbio Diagnostics, Inc. Waveguide with integrated lens
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
JP5757535B2 (ja) 2009-04-29 2015-07-29 ピーエルシー ダイアグノスティクス， インコーポレイテッド 走査光源による導波管に基づく検出システム
DE102009025073A1 (de) 2009-06-16 2010-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Optischer Sensor
DE102009025072A1 (de) * 2009-06-16 2010-12-30 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zum Erzeugen eines Bereiches mit erhöhtem Brechungsindex und ein Substrat mit örtlich variablem Brechungsindex
EP2616797B1 (en) 2010-09-15 2017-01-11 MBIO Diagnostics Inc. System and method for detecting multiple molecules in one assay
DE102011005432A1 (de) 2011-03-11 2012-09-13 Hellma Gmbh & Co. Kg Vorrichtung für die Analyse einer kleinen Flüssigkeitsmenge
EP2745100A1 (en) * 2011-09-06 2014-06-25 Koninklijke Philips N.V. Method and device for coupling a light beam into a foil
CN102829959B (zh) 2012-08-16 2014-12-17 京东方科技集团股份有限公司 一种导光板透过率光谱的测试装置及方法
KR102146641B1 (ko) * 2013-04-08 2020-08-21 스냅 아이엔씨 멀티-카메라 장치를 사용하는 거리 추정
CA2912947C (en) * 2013-05-22 2017-06-20 Imec Vzw Compact fluid analysis device and method to fabricate
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
GB2565074A (en) * 2017-07-31 2019-02-06 Univ Bristol Method and apparatus for bacterial analysis
DE102018202591A1 (de) * 2018-02-21 2019-08-22 Robert Bosch Gmbh Optisches System sowie ein Verfahren zur Herstellung eines optischen Systems
DE102018202588A1 (de) * 2018-02-21 2019-08-22 Robert Bosch Gmbh Optische Sensorvorrichtung sowie ein Verfahren zur Herstellung einer optischen Sensorvorrichtung
WO2021229432A1 (en) * 2020-05-12 2021-11-18 Moresense S.R.L. Spr sensor with waveguide and mirrors for coupling light into and out of the waveguide
JP7318632B2 (ja) * 2020-12-25 2023-08-01 横河電機株式会社 培養容器及び観察システム
CN113125421B (zh) * 2021-04-09 2022-07-12 华中农业大学 一种光纤生物传感器及其在均相化学发光生物检测中的应用
DE102021133357A1 (de) 2021-12-15 2023-06-15 Endress+Hauser Conducta Gmbh+Co. Kg Sensorelement, Sensorsystem und Verfahren zum Herstellen des Sensorelements

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8911462D0 (en) * 1989-05-18 1989-07-05 Ares Serono Res & Dev Ltd Devices for use in chemical test procedures
AU619120B2 (en) * 1989-06-22 1992-01-16 Applied Research Systems Ars Holding N.V. Method of optical analysis
CA2069537A1 (en) * 1991-06-07 1992-12-08 Thomas A. Cook Multiple output referencing system for evanescent wave sensor
US5340715A (en) * 1991-06-07 1994-08-23 Ciba Corning Diagnostics Corp. Multiple surface evanescent wave sensor with a reference

Also Published As

Publication number Publication date
WO1994027137A2 (en) 1994-11-24
ES2169079T3 (es) 2002-07-01
AU704947B2 (en) 1999-05-06
EP0700514B1 (en) 2001-11-28
DE69429262T2 (de) 2002-07-25
ATE209782T1 (de) 2001-12-15
CA2162996A1 (en) 1994-11-24
DE69429262D1 (de) 2002-01-10
EP0700514A1 (en) 1996-03-13
AU7311694A (en) 1994-12-12
WO1994027137A3 (en) 1995-01-19
CA2162996C (en) 2008-02-05
JP3426602B2 (ja) 2003-07-14
JPH08510331A (ja) 1996-10-29

Similar Documents

Publication Publication Date Title
DK0700514T3 (da) Apparat og fremgangsmåder til homogene multianalyt-fluoroimmunoassays
ES2038183T3 (es) Estructuras opticas recubiertas de polimero.
DK0680380T3 (da) Fremgangsmåder til analyse/adskillelse
KR960702906A (ko) 면역화학적 간이 반정량방법 및 장치(simple immunochemical semiquantitative assay method and apparatus)
JPS5324015A (en) Method and apparatus for detection of antigen-antibody reaction
ES2082141T3 (es) Inmunoensayo de señales visuales complementarias.
DE69942314D1 (de) Versuchsanordnung zum nachweis von bindungspartnern
BR9404242A (pt) Processo para a determinação de proteína e creatinina
ATE278944T1 (de) Vorrichtung und verfahren zur durchführung von quantitativen fluoreszenz markierten affinitätstests
DK0943097T3 (da) Fremgangsmåde til at påvise IgE
DK1034422T3 (da) Fremgangsmåde og apparat til måling af optiske egenskaber ved tilbagekoblingskontrol
ATE75048T1 (de) Verfahren und apparat zur bestimmung des antikoerperinhalts von blut.
ATE45043T1 (de) Verfahren und vorrichtung zum produzieren von mustern wechselnder konzentrationen von chemisch oder biologisch aktiven substanzen.
ATE191974T1 (de) Verfahren zur simultanen, quantitativen bestimmung, in einer einzelnen messung, der haupttypen der menschlichen lymphozyten und deren untereinheiten
DE59813433D1 (de) Aufreinigung von substanzen aus einer biologischen probe
ES2153580T3 (es) Complejos quimicos.
ATE133494T1 (de) Verfahren zur verstärkung der chemilumineszenz von enzymgetriggerten 1,2-dioxetanen und seine verwendung
EP0730739B1 (de) Verfahren zur beschichtung von oberflächen mit biomolekülen und anderen rezeptormolekülen
GB8807698D0 (en) Assay technique
DE3850993D1 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
DE69617568D1 (de) Immunoassay Vorrichtung und Testverfahren zu seiner Verwendung
DE69617498D1 (de) Vorrichtung und Verfahren zum zerstörungsfreien Testen von mit Kohärenzlicht bestrahlten Materialien
DK98692A (da) Monoklonalt antistof og fremgangsmaade til fremstilling deraf, hybridoma, som producerer det monoklonale antistof, og proeve for tumorcellefoelsomhed under anvendelse af det monoklonale antistof
ATE358818T1 (de) Verfahren zum nachweis von oberflächenfehlern in werkstoffoberflächen
ES2096596T3 (es) Procedimiento para la determinacion inmunologica de ligandos.