DK0680380T3 - Fremgangsmåder til analyse/adskillelse - Google Patents

Fremgangsmåder til analyse/adskillelse

Info

Publication number
DK0680380T3
DK0680380T3 DK94904704T DK94904704T DK0680380T3 DK 0680380 T3 DK0680380 T3 DK 0680380T3 DK 94904704 T DK94904704 T DK 94904704T DK 94904704 T DK94904704 T DK 94904704T DK 0680380 T3 DK0680380 T3 DK 0680380T3
Authority
DK
Denmark
Prior art keywords
particles
altered
twfm
separation
analysis
Prior art date
Application number
DK94904704T
Other languages
English (en)
Inventor
Alastair Roy Macgregor
Adrian Parton
Ronald Pethig
Denise Vera Pollard-Knight
Ying Huang
Xiao-Bo Wang
Original Assignee
Scient Generics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scient Generics Ltd filed Critical Scient Generics Ltd
Application granted granted Critical
Publication of DK0680380T3 publication Critical patent/DK0680380T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02Separators
    • B03C5/022Non-uniform field separators
    • B03C5/028Non-uniform field separators using travelling electric fields, i.e. travelling wave dielectrophoresis [TWD]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Sampling And Sample Adjustment (AREA)
DK94904704T 1993-01-21 1994-01-21 Fremgangsmåder til analyse/adskillelse DK0680380T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939301122A GB9301122D0 (en) 1993-01-21 1993-01-21 Method of analysis/separation
PCT/GB1994/000121 WO1994016821A1 (en) 1993-01-21 1994-01-21 Methods of analysis/separation

Publications (1)

Publication Number Publication Date
DK0680380T3 true DK0680380T3 (da) 1999-02-22

Family

ID=10729051

Family Applications (2)

Application Number Title Priority Date Filing Date
DK97115293T DK0815942T3 (da) 1993-01-21 1994-01-21 Fremgangsmåde til separation og analyse
DK94904704T DK0680380T3 (da) 1993-01-21 1994-01-21 Fremgangsmåder til analyse/adskillelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK97115293T DK0815942T3 (da) 1993-01-21 1994-01-21 Fremgangsmåde til separation og analyse

Country Status (8)

Country Link
US (2) US5653859A (da)
EP (3) EP0680380B1 (da)
JP (1) JPH08506179A (da)
AT (2) ATE204211T1 (da)
DE (2) DE69428000T2 (da)
DK (2) DK0815942T3 (da)
GB (1) GB9301122D0 (da)
WO (1) WO1994016821A1 (da)

Families Citing this family (148)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306729D0 (en) * 1993-03-31 1993-05-26 British Tech Group Improvements in separators
US6129828A (en) 1996-09-06 2000-10-10 Nanogen, Inc. Apparatus and methods for active biological sample preparation
US6225059B1 (en) 1993-11-01 2001-05-01 Nanogen, Inc. Advanced active electronic devices including collection electrodes for molecular biological analysis and diagnostics
US6331274B1 (en) 1993-11-01 2001-12-18 Nanogen, Inc. Advanced active circuits and devices for molecular biological analysis and diagnostics
DE4400955C2 (de) * 1993-12-23 1999-04-01 Fraunhofer Ges Forschung Adhäsionssteuerbare Oberflächenstruktur
US6071394A (en) * 1996-09-06 2000-06-06 Nanogen, Inc. Channel-less separation of bioparticles on a bioelectronic chip by dielectrophoresis
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
GB9507125D0 (en) * 1995-04-06 1995-05-31 Scient Generics Ltd Travelling wave electrodes
US6641708B1 (en) * 1996-01-31 2003-11-04 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
US5888370A (en) * 1996-02-23 1999-03-30 Board Of Regents, The University Of Texas System Method and apparatus for fractionation using generalized dielectrophoresis and field flow fractionation
US5993630A (en) * 1996-01-31 1999-11-30 Board Of Regents The University Of Texas System Method and apparatus for fractionation using conventional dielectrophoresis and field flow fractionation
GB9619093D0 (en) 1996-09-12 1996-10-23 Scient Generics Ltd Methods of analysis/separation
US5858192A (en) * 1996-10-18 1999-01-12 Board Of Regents, The University Of Texas System Method and apparatus for manipulation using spiral electrodes
WO1998046986A1 (en) * 1997-04-15 1998-10-22 Sarnoff Corporation Method for translocating microparticles in a microfabricated device
CA2291180A1 (en) 1997-05-23 1998-11-26 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6096368A (en) * 1998-02-19 2000-08-01 Delsys Pharmaceutical Corporation Bead transporter chucks using repulsive field guidance and method
EP2360271A1 (en) 1998-06-24 2011-08-24 Illumina, Inc. Decoding of array sensors with microspheres
DE19860117A1 (de) * 1998-12-23 2000-07-13 Evotec Biosystems Ag Elektrodenanordnung zur dielektrophoretischen Partikelablenkung
EP1089824B1 (de) 1998-06-26 2003-11-05 Evotec OAI AG Elektrodenanordnung zur dielektrophoretischen partikelablenkung
US6375901B1 (en) 1998-06-29 2002-04-23 Agilent Technologies, Inc. Chemico-mechanical microvalve and devices comprising the same
US6294063B1 (en) 1999-02-12 2001-09-25 Board Of Regents, The University Of Texas System Method and apparatus for programmable fluidic processing
US6858439B1 (en) 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
TW496775B (en) * 1999-03-15 2002-08-01 Aviva Bioscience Corp Individually addressable micro-electromagnetic unit array chips
CN1181337C (zh) * 2000-08-08 2004-12-22 清华大学 微流体系统中实体分子的操纵方法及相关试剂盒
US6942776B2 (en) * 1999-05-18 2005-09-13 Silicon Biosystems S.R.L. Method and apparatus for the manipulation of particles by means of dielectrophoresis
US6448090B1 (en) 1999-07-09 2002-09-10 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using alternating pressure waveforms
GB9916848D0 (en) * 1999-07-20 1999-09-22 Univ Wales Bangor Travelling wave dielectrophoretic apparatus and method
JP2003510034A (ja) * 1999-08-26 2003-03-18 ザ トラスティーズ オブ プリンストン ユニバーシティ 流体の静電容量の変化を検出するためのマイクロ流体およびナノ流体電子素子並びに使用方法
US6613211B1 (en) * 1999-08-27 2003-09-02 Aclara Biosciences, Inc. Capillary electrokinesis based cellular assays
US7198702B1 (en) * 1999-09-30 2007-04-03 Wako Pure Chemical Industries, Ltd. Method for separating substances using dielectrophoretic forces
US6680208B1 (en) 1999-11-19 2004-01-20 Becton, Dickinson And Company Rapid protein identification using antibody mixtures
EP1716926A3 (en) * 2000-04-13 2007-08-29 Wako Pure Chemical Industries Ltd Electrode for dielectrophoretic apparatus, dielectrophoretic apparatus, method for manufacturing the same, and method for separating substances using the electrode or dielectrophoretic apparatus
EP1350095B1 (en) * 2000-06-14 2015-12-09 The Board Of Regents, The University Of Texas System Method and apparatus for combined magnetophoretic and dielectrophoretic manipulation of analyte mixtures
ATE325657T1 (de) 2000-06-14 2006-06-15 Univ Texas Vorrichtung und verfahren zum einspritzen von flüssigkeiten
AU2001268500A1 (en) * 2000-06-14 2001-12-24 Board Of Regents, The University Of Texas System Dielectrically-engineered microparticles
US6790330B2 (en) * 2000-06-14 2004-09-14 Board Of Regents, The University Of Texas System Systems and methods for cell subpopulation analysis
EP1232678A4 (en) * 2000-07-26 2004-08-25 Univ California MANIPULATION OF LIVING CELLS AND INORGANIC OBJECTS USING MICRO-BEAM OPTICAL NETWORKS
AU2000274922A1 (en) * 2000-08-08 2002-02-18 Aviva Biosciences Corporation Methods for manipulating moieties in microfluidic systems
CN1325909C (zh) 2000-09-27 2007-07-11 清华大学 用于微粒操纵与微粒导向的装置及其使用方法
CN100495030C (zh) 2000-09-30 2009-06-03 清华大学 多力操纵装置及其应用
CA2424941A1 (en) * 2000-10-10 2002-04-18 Aviva Biosciences Corporation An integrated biochip system for sample preparation and analysis
US6744038B2 (en) 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
US6833542B2 (en) * 2000-11-13 2004-12-21 Genoptix, Inc. Method for sorting particles
US6784420B2 (en) * 2000-11-13 2004-08-31 Genoptix, Inc. Method of separating particles using an optical gradient
US20020123112A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for increasing detection sensitivity in optical dielectric sorting systems
US6936811B2 (en) * 2000-11-13 2005-08-30 Genoptix, Inc. Method for separating micro-particles
US20020121443A1 (en) * 2000-11-13 2002-09-05 Genoptix Methods for the combined electrical and optical identification, characterization and/or sorting of particles
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20030007894A1 (en) * 2001-04-27 2003-01-09 Genoptix Methods and apparatus for use of optical forces for identification, characterization and/or sorting of particles
US6778724B2 (en) 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
US6783992B2 (en) 2001-01-03 2004-08-31 Agilent Technologies, Inc. Methods and using chemico-mechanical microvalve devices for the selective separation of components from multi-component fluid samples
CN100494360C (zh) * 2001-03-22 2009-06-03 博奥生物有限公司 细胞分离方法及其应用
AU2007205731B2 (en) * 2001-03-22 2008-10-02 Capitalbio Corporation Cell isolation method and uses thereof
JP4407068B2 (ja) * 2001-03-26 2010-02-03 横河電機株式会社 磁気粒子泳動方法および装置
CA2443320C (en) 2001-04-04 2010-01-26 Wako Pure Chemical Industries Ltd. Separation of target material using affinity substance containing labelled nucleic acid chain by electrophoresis
US7572642B2 (en) * 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US20040009540A1 (en) * 2001-04-27 2004-01-15 Genoptix, Inc Detection and evaluation of cancer cells using optophoretic analysis
ITTO20010411A1 (it) * 2001-05-02 2002-11-02 Silicon Biosystems S R L Metodo e dispositivo per l'esecuzione di test e saggi ad alta processivita' ed alto valore biologico su cellule e/o composti.
US6634095B2 (en) * 2001-06-27 2003-10-21 International Business Machines Corporation Apparatus for mounting a land grid array module
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
AU2002343573A1 (en) * 2001-10-24 2003-05-06 Singulex, Inc. Methods for detecting genetic haplotypes by interaction with probes
US6703819B2 (en) 2001-12-03 2004-03-09 Board Of Regents, The University Of Texas System Particle impedance sensor
US6866762B2 (en) 2001-12-20 2005-03-15 Board Of Regents, University Of Texas System Dielectric gate and methods for fluid injection and control
US20030119057A1 (en) * 2001-12-20 2003-06-26 Board Of Regents Forming and modifying dielectrically-engineered microparticles
US6887362B2 (en) * 2002-02-06 2005-05-03 Nanogen, Inc. Dielectrophoretic separation and immunoassay methods on active electronic matrix devices
US20040033539A1 (en) * 2002-05-01 2004-02-19 Genoptix, Inc Method of using optical interrogation to determine a biological property of a cell or population of cells
US20040011652A1 (en) * 2002-07-16 2004-01-22 Bressler Vincent Edward Separation of particles using multiple conductive layers
US20040053209A1 (en) * 2002-09-12 2004-03-18 Genoptix, Inc Detection and evaluation of topoisomerase inhibitors using optophoretic analysis
US20040067167A1 (en) * 2002-10-08 2004-04-08 Genoptix, Inc. Methods and apparatus for optophoretic diagnosis of cells and particles
WO2004055505A1 (en) * 2002-12-12 2004-07-01 Aura Biosystems Inc. Dielectrophoretic particle profiling system and method
AU2003292600A1 (en) * 2002-12-25 2004-07-22 Cluster Technology Co., Ltd. Method and device for discharging liquid specimen
US7282129B2 (en) * 2003-06-12 2007-10-16 Palo Alto Research Center Incorporated Traveling wave algorithms to focus and concentrate proteins in gel electrophoresis
US7156970B2 (en) * 2003-06-12 2007-01-02 Palo Alto Research Center Incorporated Distributed multi-segmented reconfigurable traveling wave grids for separation of proteins in gel electrophoresis
US7150813B2 (en) * 2003-06-12 2006-12-19 Palo Alto Research Center Incorporated Isoelectric focusing (IEF) of proteins with sequential and oppositely directed traveling waves in gel electrophoresis
US20090088982A1 (en) * 2003-07-31 2009-04-02 Fukushima Noelle H Co-detection of single polypeptide and polynucleotide molecules
AU2004269406B2 (en) 2003-08-28 2010-12-16 Progenity, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US20080021674A1 (en) * 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
US7163611B2 (en) 2003-12-03 2007-01-16 Palo Alto Research Center Incorporated Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids
US7309410B2 (en) 2003-12-03 2007-12-18 Palo Alto Research Center Incorporated Traveling wave grids and algorithms for biomolecule separation, transport and focusing
US20050148065A1 (en) 2003-12-30 2005-07-07 Intel Corporation Biosensor utilizing a resonator having a functionalized surface
US7384791B2 (en) * 2004-01-21 2008-06-10 Hewlett-Packard Development Company, L.P. Method of analyzing blood
US7390387B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells in series
US7160425B2 (en) * 2004-03-25 2007-01-09 Hewlett-Packard Development Company, L.P. Cell transporter for a biodevice
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
US7534336B2 (en) * 2004-05-04 2009-05-19 Palo Alto Research Center Incorporated Continuous flow particle concentrator
US7491307B2 (en) * 2004-05-04 2009-02-17 Palo Alto Research Center Incorporated Portable bioagent concentrator
US8974652B2 (en) * 2004-05-28 2015-03-10 Board Of Regents, The University Of Texas System Programmable fluidic processors
ITBO20040420A1 (it) * 2004-07-07 2004-10-07 Type S R L Macchina per taglio e formatura di piattine metalliche
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
US8685711B2 (en) * 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
JP2008514955A (ja) * 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
DE102004056749B3 (de) * 2004-11-24 2006-05-04 Beru Ag Drucksensor für eine Druckmessglühkerze einer Brennkraftmaschine
WO2007044029A2 (en) 2004-12-03 2007-04-19 Nano Science Diagnostic, Inc. Method and apparatus for low quantity detection of bioparticles in small sample volumes
KR100594408B1 (ko) 2004-12-17 2006-06-30 한국과학기술연구원 초음파장 및 진행파 유전영동을 이용한 세포 분리 장치
JP4462051B2 (ja) * 2005-01-28 2010-05-12 富士ゼロックス株式会社 微粒子分散液の濃縮方法、及び微粒子分散液の濃縮装置
US20060194143A1 (en) * 2005-02-25 2006-08-31 Shinichi Sumida Fluorine-containing polymerizable monomers, fluorine-containing polymer compounds, resist compositions using the same, and patterning process
US7471055B2 (en) * 2005-03-15 2008-12-30 The Boeing Company Controller, drive assembly and half-bridge assembly for providing a voltage
US7681738B2 (en) * 2005-09-12 2010-03-23 Palo Alto Research Center Incorporated Traveling wave arrays, separation methods, and purification cells
KR101157175B1 (ko) * 2005-12-14 2012-07-03 삼성전자주식회사 세포 또는 바이러스의 농축 및 용해용 미세유동장치 및방법
US7838250B1 (en) * 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
AU2007313488A1 (en) 2006-04-04 2008-04-24 Singulex, Inc. Methods and compositions for highly sensitive analysis of markers and detection of molecules
EP3156799B1 (en) 2006-04-04 2024-01-24 Novilux, LLC Analyzer and method for highly sensitive detection of analytes
WO2007136306A1 (en) * 2006-05-19 2007-11-29 Telefonaktiebolaget L M Ericsson (Publ) Method and arrangement in a communication system
CN101583722A (zh) 2006-07-14 2009-11-18 阿维瓦生物科学股份有限公司 从生物学样品检测稀有细胞的方法和组合物
KR100778762B1 (ko) 2006-07-18 2007-11-27 한국과학기술원 유로 내 입자의 이동특성 분석기 및 그 분석방법
ATE472372T1 (de) 2006-10-26 2010-07-15 Imec Handhabung von magnetischen oder magnetisierbaren objekten unter verwendung von kombinierter magnetophorese und dielektrophorese
US9486812B2 (en) * 2006-11-30 2016-11-08 Palo Alto Research Center Incorporated Fluidic structures for membraneless particle separation
US10052571B2 (en) * 2007-11-07 2018-08-21 Palo Alto Research Center Incorporated Fluidic device and method for separation of neutrally buoyant particles
US8931644B2 (en) * 2006-11-30 2015-01-13 Palo Alto Research Center Incorporated Method and apparatus for splitting fluid flow in a membraneless particle separation system
US9433880B2 (en) * 2006-11-30 2016-09-06 Palo Alto Research Center Incorporated Particle separation and concentration system
US8276760B2 (en) 2006-11-30 2012-10-02 Palo Alto Research Center Incorporated Serpentine structures for continuous flow particle separations
US9862624B2 (en) * 2007-11-07 2018-01-09 Palo Alto Research Center Incorporated Device and method for dynamic processing in water purification
EP2045601A1 (en) * 2007-03-26 2009-04-08 Koninklijke Philips Electronics N.V. Use of microcarrier beads for detection and/or isolation of cells by flow cytometry and/or dielectrophoresis
US8698031B2 (en) 2007-04-17 2014-04-15 Dynamic Connections, Llc Separation and manipulation of a chiral object
US20090087860A1 (en) * 2007-08-24 2009-04-02 Todd John A Highly sensitive system and methods for analysis of prostate specific antigen (psa)
EP2039433A1 (en) * 2007-08-31 2009-03-25 Koninklijke Philips Electronics N.V. Dielectrophoretic device for manipulation of particles
EP2052783A1 (en) * 2007-10-22 2009-04-29 Koninklijke Philips Electronics N.V. Manipulation of particles by dielectrophoresis
EP2232271B1 (en) 2007-12-19 2019-09-11 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US9480935B2 (en) * 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
US20090234202A1 (en) * 2008-03-05 2009-09-17 Goix Philippe J Method and compositions for highly sensitive detection of molecules
EP2265714A4 (en) * 2008-03-21 2011-09-28 Dynamic Connections Llc MOVING A SMALL OBJECT INTO A DIRECTION
CN103353476B (zh) * 2008-04-03 2016-05-25 加利福尼亚大学董事会 分离并离析细胞、囊泡、纳米颗粒和生物标记的离体多维系统
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
EP2358898B1 (en) * 2008-11-17 2016-08-31 Headway Technologies, Inc. Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs
WO2010056577A1 (en) * 2008-11-17 2010-05-20 Magic Technologies, Inc. Methods and compositions in particle-based detection of target molecules using linking molecules
US9447461B2 (en) 2009-03-24 2016-09-20 California Institute Of Technology Analysis devices, kits, and related methods for digital quantification of nucleic acids and other analytes
US10196700B2 (en) 2009-03-24 2019-02-05 University Of Chicago Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes
CN104722342B (zh) 2009-03-24 2017-01-11 芝加哥大学 滑动式芯片装置和方法
US9464319B2 (en) 2009-03-24 2016-10-11 California Institute Of Technology Multivolume devices, kits and related methods for quantification of nucleic acids and other analytes
US8450069B2 (en) * 2009-06-08 2013-05-28 Singulex, Inc. Highly sensitive biomarker panels
US8772004B2 (en) * 2009-06-25 2014-07-08 Old Dominion University Research Foundation System and method for high-voltage pulse assisted aggregation of algae
US8658056B1 (en) 2010-05-05 2014-02-25 The United States Of America As Represented By The Secretary Of The Air Force Harvesting single domain nanoparticles and their applications
US20110301053A1 (en) 2010-05-06 2011-12-08 Singulex, Inc. Methods for Diagnosing, Staging, Predicting Risk for Developing and Identifying Treatment Responders for Rheumatoid Arthritis
DE102010036082B4 (de) * 2010-08-26 2015-07-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Mikrofluidischer Messaufbau und optisches Analyseverfahren zur optischen Analyse von Zellen
CN103476951B (zh) 2011-02-16 2017-07-28 海德威技术公司 用于可检测的标记的靶标定位锚定的方法和组合物
US8702991B2 (en) * 2012-07-12 2014-04-22 Heliae Development, Llc Electrical microorganism aggregation methods
US8668827B2 (en) * 2012-07-12 2014-03-11 Heliae Development, Llc Rectangular channel electro-acoustic aggregation device
US8673154B2 (en) * 2012-07-12 2014-03-18 Heliae Development, Llc Tunable electrical field for aggregating microorganisms
US8709250B2 (en) * 2012-07-12 2014-04-29 Heliae Development, Llc Tubular electro-acoustic aggregation device
US8709258B2 (en) * 2012-07-12 2014-04-29 Heliae Development, Llc Patterned electrical pulse microorganism aggregation
CN105683745A (zh) * 2013-08-29 2016-06-15 阿波赛尔公司 用于目标颗粒的分离、捕获和分子分析的方法和装置
US10274492B2 (en) * 2015-04-10 2019-04-30 The Curators Of The University Of Missouri High sensitivity impedance sensor
US9873129B1 (en) * 2016-12-19 2018-01-23 Charlot Biosciences, Inc. Multi-planar microelectrode array device and methods of making and using same
JP7543048B2 (ja) * 2020-09-18 2024-09-02 シスメックス株式会社 細胞分析方法及びシステム
WO2022176048A1 (ja) * 2021-02-17 2022-08-25 日本電信電話株式会社 粒子配列運搬デバイスおよび方法
EP4089394A1 (en) * 2021-05-11 2022-11-16 Ceidos SA Cell culture monitoring system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE412745C (de) * 1922-10-03 1925-04-27 Josef Horn Mehrfarben-Schoen- und Widerdruck-Gummidruck-Rotationsmaschine
US4390403A (en) * 1981-07-24 1983-06-28 Batchelder J Samuel Method and apparatus for dielectrophoretic manipulation of chemical species
US4900414A (en) * 1988-08-19 1990-02-13 Drug Delivery Systems Inc. Commercial separation system and method using electrokinetic techniques
US5108568A (en) * 1989-07-07 1992-04-28 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Controlled method of reducing electrophoretic mobility of macromolecules, particles or cells
US5284558A (en) * 1990-07-27 1994-02-08 University Of Iowa Research Foundation Electrophoresis-based sequencing of oligosaccharides
DE4034697A1 (de) * 1990-10-31 1992-05-14 Fraunhofer Ges Forschung Verfahren zur handhabung mikroskopisch kleiner, dielektrischer teilchen und vorrichtung zur durchfuehrung des verfahrens
EP0519250A3 (en) * 1991-06-10 1993-06-02 Miles Inc. Microparticle-labeled binding assay analyzed by microwave spectroscopy
DE4143573C2 (de) * 1991-08-19 1996-07-04 Fraunhofer Ges Forschung Vorrichtung zur Trennung von Gemischen mikroskopisch kleiner, in einer Flüssigkeit oder einem Gel suspendierter, dielektrischer Teilchen
WO1993004199A2 (en) * 1991-08-20 1993-03-04 Scientific Generics Limited Methods of detecting or quantitating nucleic acids and of producing labelled immobilised nucleic acids
US5228960A (en) * 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
US5431793A (en) * 1994-07-29 1995-07-11 Beckman Instruments, Inc. Quantitative analysis of glycosylated hemoglobin by immunocappillary electrophoresis

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EP1092477A1 (en) 2001-04-18
ATE204211T1 (de) 2001-09-15
JPH08506179A (ja) 1996-07-02
US5653859A (en) 1997-08-05
US5993631A (en) 1999-11-30
DE69409788T2 (de) 1998-11-12
GB9301122D0 (en) 1993-03-10
EP0815942A1 (en) 1998-01-07
DK0815942T3 (da) 2001-11-12
EP0815942B1 (en) 2001-08-16
DE69428000T2 (de) 2002-04-04
WO1994016821A1 (en) 1994-08-04
EP0680380A1 (en) 1995-11-08
DE69409788D1 (de) 1998-05-28
EP0680380B1 (en) 1998-04-22
DE69428000D1 (de) 2001-09-20
ATE165255T1 (de) 1998-05-15

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