DK0693077T3 - Antivirusforbindelser - Google Patents

Antivirusforbindelser

Info

Publication number
DK0693077T3
DK0693077T3 DK94912709T DK94912709T DK0693077T3 DK 0693077 T3 DK0693077 T3 DK 0693077T3 DK 94912709 T DK94912709 T DK 94912709T DK 94912709 T DK94912709 T DK 94912709T DK 0693077 T3 DK0693077 T3 DK 0693077T3
Authority
DK
Denmark
Prior art keywords
pct
nucleoside analog
mono
sec
formula
Prior art date
Application number
DK94912709T
Other languages
English (en)
Inventor
Kjell Torgeir Stokke
Bernt Borretzen
Are Dalen
Finn Myhren
Original Assignee
Norsk Hydro As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Norsk Hydro As filed Critical Norsk Hydro As
Application granted granted Critical
Publication of DK0693077T3 publication Critical patent/DK0693077T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK94912709T 1993-04-05 1994-04-05 Antivirusforbindelser DK0693077T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939307043A GB9307043D0 (en) 1993-04-05 1993-04-05 Chemical compounds
PCT/NO1994/000071 WO1994022887A1 (en) 1993-04-05 1994-04-05 New antiviral compounds

Publications (1)

Publication Number Publication Date
DK0693077T3 true DK0693077T3 (da) 1999-06-14

Family

ID=10733340

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94912709T DK0693077T3 (da) 1993-04-05 1994-04-05 Antivirusforbindelser

Country Status (20)

Country Link
US (1) US6153594A (da)
EP (1) EP0693077B1 (da)
JP (1) JP3049258B2 (da)
KR (1) KR100309194B1 (da)
AT (1) ATE171457T1 (da)
AU (1) AU685104B2 (da)
CA (1) CA2158853C (da)
CZ (1) CZ287755B6 (da)
DE (1) DE69413529T2 (da)
DK (1) DK0693077T3 (da)
ES (1) ES2124883T3 (da)
FI (1) FI111370B (da)
GB (1) GB9307043D0 (da)
HU (1) HU228064B1 (da)
NZ (1) NZ263888A (da)
PL (1) PL177263B1 (da)
RU (1) RU2139884C1 (da)
SK (1) SK281231B6 (da)
UA (1) UA41361C2 (da)
WO (1) WO1994022887A1 (da)

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US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
NZ336676A (en) * 1997-01-24 2000-01-28 Norsk Hydro As Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
US5891881A (en) * 1997-11-21 1999-04-06 Clarion Pharmaceuticals Inc. Aminoheterocycle-substituted glycerols
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NZ509233A (en) 1998-07-09 2003-05-30 Sankyo Co Antibacterial compounds related to capuramycin
ATE313550T1 (de) * 1998-08-10 2006-01-15 Idenix Cayman Ltd Beta-l-2'-deoxynukleoside für die behandlung von hepatitis b virus
US6277830B1 (en) 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
ES2229820T3 (es) * 1998-10-16 2005-04-16 Schering Corporation Terapia de combinacion ribavirina-interferon alfa para erradicar el hcv-rna detectable en pacientes con infeccion por hepatitis c cronica.
US6403564B1 (en) 1998-10-16 2002-06-11 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
US7235583B1 (en) 1999-03-09 2007-06-26 Luitpold Pharmaceuticals, Inc., Fatty acid-anticancer conjugates and uses thereof
TWI245047B (en) 1999-08-20 2005-12-11 Sankyo Co Novel A-500359 derivatives
US7638496B2 (en) 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
WO2001081359A1 (en) * 2000-04-20 2001-11-01 Schering Corporation Ribavirin-interferon alfa combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
WO2003062388A2 (en) * 2002-01-16 2003-07-31 The Regents Of The University Of California Inhibition of rna function
AP2005003213A0 (en) 2002-06-28 2005-03-31 Univ Cagliari 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections.
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US20040077607A1 (en) * 2002-10-21 2004-04-22 Uckun Fatih M. Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses
WO2004039995A1 (en) * 2002-11-01 2004-05-13 Evogenix Pty Ltd Mutagenesis methods using ribavirin and/or rna replicases
US7824851B2 (en) 2002-11-15 2010-11-02 Idenix Pharmaceuticals, Inc. 2′-branched nucleosides and Flaviviridae mutation
TWI332507B (en) * 2002-11-19 2010-11-01 Hoffmann La Roche Antiviral nucleoside derivatives
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
WO2004084453A2 (en) * 2003-03-20 2004-09-30 Microbiologica Quimica E Farmaceutica Ltd. METHODS OF MANUFACTURE OF 2'-DEOXY-β-L-NUCLEOSIDES
WO2005049633A1 (en) * 2003-11-03 2005-06-02 Cognis Ip Management Gmbh Acyl ribonucleosides and acyl deoxyribonucleosides
FR2874016B1 (fr) * 2004-06-30 2006-11-24 Centre Nat Rech Scient Cnrse Nanoparticules de derives de la gemcitabine
US8114847B2 (en) 2005-03-16 2012-02-14 Case Western Reserve University Selective inhibitors of translesion DNA replication
US9029345B2 (en) * 2005-03-16 2015-05-12 Case Western Reserve University Selective inhibitors of translesion DNA replication
NO324263B1 (no) * 2005-12-08 2007-09-17 Clavis Pharma Asa Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
ES2422290T3 (es) 2005-12-23 2013-09-10 Idenix Pharmaceuticals Inc Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados
US8497292B2 (en) * 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
UA99308C2 (ru) * 2007-09-26 2012-08-10 Маунт Синай Скул Оф Медсин Аналог азацитидина и его применение
US9988680B2 (en) 2011-09-01 2018-06-05 Case Western Reserve University Non-natural nucleosides as theranostic agents
US9821173B2 (en) 2013-02-08 2017-11-21 Case Western Reserve University Anti-cancer agents and methods of use

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Also Published As

Publication number Publication date
PL310970A1 (en) 1996-01-22
AU685104B2 (en) 1998-01-15
DE69413529D1 (de) 1998-10-29
HU9502896D0 (en) 1995-11-28
PL177263B1 (pl) 1999-10-29
JPH08508477A (ja) 1996-09-10
CZ259395A3 (en) 1996-06-12
DE69413529T2 (de) 1999-04-29
AU6514194A (en) 1994-10-24
SK123395A3 (en) 1996-04-03
CA2158853A1 (en) 1994-10-13
WO1994022887A1 (en) 1994-10-13
CZ287755B6 (en) 2001-01-17
SK281231B6 (sk) 2001-01-18
FI111370B (fi) 2003-07-15
HUT73659A (en) 1996-09-30
ATE171457T1 (de) 1998-10-15
KR100309194B1 (ko) 2002-06-20
CA2158853C (en) 1999-07-27
EP0693077A1 (en) 1996-01-24
RU2139884C1 (ru) 1999-10-20
NZ263888A (en) 1998-05-27
EP0693077B1 (en) 1998-09-23
HU228064B1 (en) 2012-09-28
FI954727L (fi) 1995-10-04
UA41361C2 (uk) 2001-09-17
FI954727A0 (fi) 1995-10-04
HK1003437A1 (en) 1998-10-30
US6153594A (en) 2000-11-28
JP3049258B2 (ja) 2000-06-05
ES2124883T3 (es) 1999-02-16
GB9307043D0 (en) 1993-05-26

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