ATE92498T1 - Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes. - Google Patents
Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes.Info
- Publication number
- ATE92498T1 ATE92498T1 AT85902625T AT85902625T ATE92498T1 AT E92498 T1 ATE92498 T1 AT E92498T1 AT 85902625 T AT85902625 T AT 85902625T AT 85902625 T AT85902625 T AT 85902625T AT E92498 T1 ATE92498 T1 AT E92498T1
- Authority
- AT
- Austria
- Prior art keywords
- separation
- methods
- antibiotic complex
- pct
- primycin components
- Prior art date
Links
- 230000003115 biocidal effect Effects 0.000 title abstract 3
- NYWSLZMTZNODJM-MCGDBQAWSA-N 2-[5-[(4e,20e)-35-butyl-19-[(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-10,12,14,16,18,22,26,30,34-nonahydroxy-3,5,21,33-tetramethyl-36-oxo-1-oxacyclohexatriaconta-4,20-dien-2-yl]-4-hydroxyhexyl]guanidine Chemical compound OC1CC(O)CC(O)CC(O)CC(O)CCCC\C(C)=C\C(C)C(C(C)C(O)CCCN=C(N)N)OC(=O)C(CCCC)C(O)C(C)CCC(O)CCCC(O)CCCC(O)\C(C)=C\C1O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NYWSLZMTZNODJM-MCGDBQAWSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229950010664 primycin Drugs 0.000 title 1
- NYWSLZMTZNODJM-SDUQVVOESA-N primycin Natural products CCCC[C@H]1[C@H](O)[C@H](C)CC[C@@H](O)CCC[C@@H](O)CCC[C@@H](O)C(=C[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)C[C@H](O)C[C@@H](O)C[C@H](O)C[C@H](O)CCCCC(=C[C@@H](C)[C@@H](OC1=O)[C@H](C)[C@H](O)CCCNC(=N)N)C)C NYWSLZMTZNODJM-SDUQVVOESA-N 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU212584A HU195514B (en) | 1984-05-31 | 1984-05-31 | Process for the digestion of triamycine, an antibioticcomplex |
| HU842869A HU196425B (en) | 1984-07-26 | 1984-07-26 | Process for producing components of primicin and pharmaceutical compositions containing them |
| EP85902625A EP0182851B1 (de) | 1984-05-31 | 1985-05-31 | Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes |
| PCT/HU1985/000034 WO1985005621A1 (en) | 1984-05-31 | 1985-05-31 | Primysin components and process for the separation of the antibiotic complex |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE92498T1 true ATE92498T1 (de) | 1993-08-15 |
Family
ID=26317473
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85902625T ATE92498T1 (de) | 1984-05-31 | 1985-05-31 | Primycinkomponenten und verfahren zur trennung des antibiotischen komplexes. |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US4873348A (de) |
| EP (1) | EP0182851B1 (de) |
| KR (1) | KR930000164B1 (de) |
| AT (1) | ATE92498T1 (de) |
| CA (1) | CA1274508A (de) |
| DE (1) | DE3587499T2 (de) |
| DK (1) | DK46086A (de) |
| FI (1) | FI80046C (de) |
| IL (1) | IL75357A (de) |
| WO (1) | WO1985005621A1 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU202248B (en) * | 1988-06-14 | 1991-02-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pseudo-primicin, it's components and pharmaceutical compositions containing them as active components |
| HU205366B (en) * | 1988-11-18 | 1992-04-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing water-soluble primycin complexes and pharmaceutical compositions comprising such active ingredient |
| HU207222B (en) * | 1990-02-15 | 1993-03-29 | Chinoin Gyogyszer Es Vegyeszet | Process for producing eyedrops containing primycin |
| US20030091540A1 (en) * | 2001-10-16 | 2003-05-15 | Nawaz Ahmad | Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity |
| US8026407B2 (en) * | 2006-08-01 | 2011-09-27 | 3M Innovative Properties Company | Antimicrobial compression bandage |
| WO2009143175A2 (en) * | 2008-05-19 | 2009-11-26 | Children's Medical Center Corporation | Sensory-specific local anesthesia and prolonged duration local anesthesia |
| US8952152B2 (en) | 2009-03-24 | 2015-02-10 | Proteus S.A. | Methods for purifying phycotoxins, pharmaceutical compositions containing purified phycotoxins, and methods of use thereof |
| HU229804B1 (en) | 2009-10-29 | 2014-07-28 | Pannonpharma Gyogyszergyarto Kft | Method of production of primycin, primycin components, and/or precursors and metabolites of primycin via fementation by the use of bacterial species saccharomonospora azurea |
| HU230455B1 (hu) | 2011-10-25 | 2016-07-28 | Pannonpharma Gyógyszergyártó Zrt. | Primycin vagy primycin komponensek vagy ezek kombinációi mint speciális kórokozócsoportok által okozott fertőzések kezelésére vagy megelőzésére alkalmas gyógyszerhatóanyagok |
| EP2968225B1 (de) | 2013-03-15 | 2019-02-20 | The Children's Medical Center Corporation | Neosaxitoxinkombinationsformulierungen für verlängerte lokalanästhesie |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT268522B (de) * | 1965-10-20 | 1969-02-10 | Chinoin Gyogyszer Es Vegyeszet | Verfahren zur Herstellung von Primycin |
| US4070376A (en) * | 1974-02-04 | 1978-01-24 | Hoffmann-La Roche, Inc. | Antibiotic 1745A/X and methods for the production thereof |
-
1985
- 1985-05-30 CA CA000482772A patent/CA1274508A/en not_active Expired - Lifetime
- 1985-05-31 EP EP85902625A patent/EP0182851B1/de not_active Expired - Lifetime
- 1985-05-31 AT AT85902625T patent/ATE92498T1/de active
- 1985-05-31 DE DE85902625T patent/DE3587499T2/de not_active Expired - Fee Related
- 1985-05-31 KR KR1019860700058A patent/KR930000164B1/ko not_active Expired - Fee Related
- 1985-05-31 WO PCT/HU1985/000034 patent/WO1985005621A1/en not_active Ceased
- 1985-05-31 US US06/834,333 patent/US4873348A/en not_active Expired - Fee Related
- 1985-05-31 IL IL75357A patent/IL75357A/xx unknown
-
1986
- 1986-01-29 FI FI860426A patent/FI80046C/fi not_active IP Right Cessation
- 1986-01-30 DK DK46086A patent/DK46086A/da unknown
-
1989
- 1989-08-30 US US07/400,688 patent/US5093359A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI80046B (fi) | 1989-12-29 |
| IL75357A0 (en) | 1985-09-29 |
| KR860700121A (ko) | 1986-03-31 |
| FI860426A0 (fi) | 1986-01-29 |
| IL75357A (en) | 1992-05-25 |
| DE3587499D1 (de) | 1993-09-09 |
| US4873348A (en) | 1989-10-10 |
| EP0182851A1 (de) | 1986-06-04 |
| WO1985005621A1 (en) | 1985-12-19 |
| DK46086D0 (da) | 1986-01-30 |
| EP0182851B1 (de) | 1993-08-04 |
| FI80046C (fi) | 1990-04-10 |
| DE3587499T2 (de) | 1993-11-25 |
| DK46086A (da) | 1986-01-30 |
| CA1274508A (en) | 1990-09-25 |
| US5093359A (en) | 1992-03-03 |
| FI860426L (fi) | 1986-01-29 |
| KR930000164B1 (ko) | 1993-01-11 |
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