DK0686156T3 - Pyrazoltriaziner med inhiberende aktivitet over for interleukin-1 og tumornekrosefaktor - Google Patents
Pyrazoltriaziner med inhiberende aktivitet over for interleukin-1 og tumornekrosefaktorInfo
- Publication number
- DK0686156T3 DK0686156T3 DK94906381T DK94906381T DK0686156T3 DK 0686156 T3 DK0686156 T3 DK 0686156T3 DK 94906381 T DK94906381 T DK 94906381T DK 94906381 T DK94906381 T DK 94906381T DK 0686156 T3 DK0686156 T3 DK 0686156T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- suitable substituent
- pct
- triazines
- pyrazole
- Prior art date
Links
- RHGUVXGNJQGWFO-UHFFFAOYSA-N 1h-pyrazole;triazine Chemical class C=1C=NNC=1.C1=CN=NN=C1 RHGUVXGNJQGWFO-UHFFFAOYSA-N 0.000 title 1
- 102000000589 Interleukin-1 Human genes 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 6
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939303993A GB9303993D0 (en) | 1993-02-26 | 1993-02-26 | New heterocyclic derivatives |
| PCT/JP1994/000213 WO1994019350A1 (en) | 1993-02-26 | 1994-02-09 | Pyrazolitriazines with interleukin-1 and tumour necrosis factor inhibitory activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0686156T3 true DK0686156T3 (da) | 2002-11-11 |
Family
ID=10731142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94906381T DK0686156T3 (da) | 1993-02-26 | 1994-02-09 | Pyrazoltriaziner med inhiberende aktivitet over for interleukin-1 og tumornekrosefaktor |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5670503A (OSRAM) |
| EP (1) | EP0686156B1 (OSRAM) |
| JP (1) | JP3569917B2 (OSRAM) |
| KR (1) | KR100313615B1 (OSRAM) |
| CN (1) | CN1041929C (OSRAM) |
| AT (1) | ATE220677T1 (OSRAM) |
| AU (1) | AU681625B2 (OSRAM) |
| CA (1) | CA2156919A1 (OSRAM) |
| DE (1) | DE69430988T2 (OSRAM) |
| DK (1) | DK0686156T3 (OSRAM) |
| ES (1) | ES2176235T3 (OSRAM) |
| GB (1) | GB9303993D0 (OSRAM) |
| HU (1) | HUT70832A (OSRAM) |
| IL (1) | IL108562A (OSRAM) |
| MX (1) | MX9401408A (OSRAM) |
| PT (1) | PT686156E (OSRAM) |
| RU (1) | RU2124517C1 (OSRAM) |
| TW (1) | TW260669B (OSRAM) |
| WO (1) | WO1994019350A1 (OSRAM) |
| ZA (1) | ZA94787B (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69723267T2 (de) | 1996-04-25 | 2004-04-22 | Nissan Chemical Industries, Ltd. | Ethylenderivate und pestizide |
| US6087381A (en) | 1997-05-22 | 2000-07-11 | G. D. Searle & Company | Pyrazole derivatives as p38 kinase inhibitors |
| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| AU742293B2 (en) | 1997-06-12 | 2001-12-20 | Aventis Pharma Limited | Imidazolyl-cyclic acetals |
| AU7966198A (en) | 1997-06-13 | 1998-12-30 | Smithkline Beecham Corporation | Novel pyrazole and pyrazoline substituted compounds |
| EP1029851B1 (en) * | 1997-10-14 | 2005-04-20 | Mitsubishi Pharma Corporation | Piperazine compounds and medicinal use thereof |
| CA2314980A1 (en) | 1997-12-19 | 1999-07-01 | Smithkline Beecham Corporation | Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO2000010563A1 (en) * | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| ATE258055T1 (de) | 1998-11-04 | 2004-02-15 | Smithkline Beecham Corp | Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine |
| WO2001015525A1 (en) * | 1999-08-31 | 2001-03-08 | Fujisawa Pharmaceutical Co., Ltd. | Organ preservatives |
| PT1140939E (pt) * | 1999-11-10 | 2005-05-31 | Ortho Mcneil Pharm Inc | 2-aril-3-(heteroaril)- imidazo [1,2-alfa] pirimidinas substituidas, e formulacoes farmaceuticas e metodos relacionados |
| US7253169B2 (en) | 1999-11-12 | 2007-08-07 | Gliamed, Inc. | Aza compounds, pharmaceutical compositions and methods of use |
| US6417189B1 (en) * | 1999-11-12 | 2002-07-09 | Gpi Nil Holdings, Inc. | AZA compounds, pharmaceutical compositions and methods of use |
| US6759410B1 (en) | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| ES2249309T3 (es) | 1999-11-23 | 2006-04-01 | Smithkline Beecham Corp | Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa. |
| US7053099B1 (en) | 1999-11-23 | 2006-05-30 | Smithkline Beecham Corporation | 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors |
| JP2003514900A (ja) | 1999-11-23 | 2003-04-22 | スミスクライン・ビーチャム・コーポレイション | ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４−ジヒドロ−（１Ｈ）−キナゾリン−２−オン化合物 |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| AU2002246855B2 (en) | 2000-10-23 | 2005-12-22 | Smithkline Beecham Corporation | Novel compounds |
| RU2316556C2 (ru) * | 2000-11-17 | 2008-02-10 | Бристол-Маерс Сквибб Компани | СПОСОБЫ ЛЕЧЕНИЯ СОСТОЯНИЙ, ОБУСЛОВЛЕННЫХ p38 КИНАЗАМИ, И ПИРРОЛОТРИАЗИНОВЫЕ СОЕДИНЕНИЯ, ПРИМЕНИМЫЕ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗ |
| JP2004518731A (ja) * | 2000-12-28 | 2004-06-24 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | 三環式ｃｒｆレセプターアンタゴニスト |
| EA007782B1 (ru) | 2001-05-24 | 2007-02-27 | Эли Лилли Энд Компани | Новые производные пиррола в качестве фармацевтических средств |
| US6821971B2 (en) * | 2001-09-20 | 2004-11-23 | The Procter & Gamble Company | Fused pyrazolone compounds which inhibit the release of inflammatory cytokines |
| KR20040103972A (ko) | 2002-04-19 | 2004-12-09 | 스미스클라인 비참 코포레이션 | 신규 화합물 |
| ES2278170T3 (es) | 2002-07-09 | 2007-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. |
| KR101050700B1 (ko) * | 2002-08-26 | 2011-07-20 | 다케다 야쿠힌 고교 가부시키가이샤 | 칼슘 수용체 조절 화합물 및 이의 용도 |
| AU2004210127B2 (en) | 2003-01-27 | 2009-10-01 | Merck Sharp & Dohme Corp. | Substituted pyrazoles, compositions containing such compounds and methods of use |
| MXPA06014084A (es) | 2004-06-04 | 2007-02-15 | Merck & Co Inc | Derivados de pirazol, composiciones que contienen dichos compuestos y metodos de uso. |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| SG160438A1 (en) | 2005-03-25 | 2010-04-29 | Glaxo Group Ltd | Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives |
| US20090137550A1 (en) | 2005-03-25 | 2009-05-28 | Glaxo Group Limited | Novel Compounds |
| UY29440A1 (es) | 2005-03-25 | 2006-10-02 | Glaxo Group Ltd | Nuevos compuestos |
| PE20100741A1 (es) | 2005-03-25 | 2010-11-25 | Glaxo Group Ltd | COMPUESTOS DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2(1H)-ONA COMO INHIBIDORES DE QUINASA p38 |
| WO2007015999A2 (en) * | 2005-07-26 | 2007-02-08 | Merck & Co., Inc. | Process for synthesizing a substituted pyrazole |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| US20110195962A1 (en) * | 2007-08-16 | 2011-08-11 | Alcon Research, Ltd. | Use of multi-pharmacophore compounds to treat nasal disorders |
| EP2203453A1 (en) * | 2007-09-20 | 2010-07-07 | Wyeth a Corporation of the State of Delaware | Pyrazolo[5, 1-c] [1,2,4]triazines, methods for preparation and use thereof |
| CN101441972B (zh) | 2007-11-23 | 2011-01-26 | 鸿富锦精密工业（深圳）有限公司 | 场发射像素管 |
| CN101441969B (zh) | 2007-11-23 | 2010-07-28 | 清华大学 | 场发射像素管 |
| EP2402344A1 (en) * | 2010-06-29 | 2012-01-04 | Basf Se | Pyrazole fused bicyclic compounds |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992012154A1 (en) * | 1990-12-31 | 1992-07-23 | Fujisawa Pharmaceutical Co., Ltd. | Imidazotriazine derivatives |
| US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1993
- 1993-02-26 GB GB939303993A patent/GB9303993D0/en active Pending
-
1994
- 1994-02-04 IL IL108562A patent/IL108562A/xx not_active IP Right Cessation
- 1994-02-04 ZA ZA94787A patent/ZA94787B/xx unknown
- 1994-02-09 HU HU9402459A patent/HUT70832A/hu unknown
- 1994-02-09 WO PCT/JP1994/000213 patent/WO1994019350A1/en active IP Right Grant
- 1994-02-09 US US08/505,284 patent/US5670503A/en not_active Expired - Fee Related
- 1994-02-09 CA CA002156919A patent/CA2156919A1/en not_active Abandoned
- 1994-02-09 AT AT94906381T patent/ATE220677T1/de not_active IP Right Cessation
- 1994-02-09 PT PT94906381T patent/PT686156E/pt unknown
- 1994-02-09 EP EP94906381A patent/EP0686156B1/en not_active Expired - Lifetime
- 1994-02-09 DK DK94906381T patent/DK0686156T3/da active
- 1994-02-09 JP JP51881094A patent/JP3569917B2/ja not_active Expired - Fee Related
- 1994-02-09 AU AU60108/94A patent/AU681625B2/en not_active Ceased
- 1994-02-09 CN CN94191768A patent/CN1041929C/zh not_active Expired - Fee Related
- 1994-02-09 ES ES94906381T patent/ES2176235T3/es not_active Expired - Lifetime
- 1994-02-09 KR KR1019950703609A patent/KR100313615B1/ko not_active Expired - Fee Related
- 1994-02-09 DE DE69430988T patent/DE69430988T2/de not_active Expired - Fee Related
- 1994-02-09 RU RU95117872A patent/RU2124517C1/ru active
- 1994-02-18 TW TW083101366A patent/TW260669B/zh active
- 1994-02-24 MX MX9401408A patent/MX9401408A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU6010894A (en) | 1994-09-14 |
| CN1041929C (zh) | 1999-02-03 |
| CN1120840A (zh) | 1996-04-17 |
| DE69430988D1 (de) | 2002-08-22 |
| DE69430988T2 (de) | 2002-11-28 |
| HU9402459D0 (en) | 1994-11-28 |
| KR100313615B1 (ko) | 2002-05-30 |
| ES2176235T3 (es) | 2002-12-01 |
| AU681625B2 (en) | 1997-09-04 |
| IL108562A (en) | 1997-06-10 |
| GB9303993D0 (en) | 1993-04-14 |
| CA2156919A1 (en) | 1994-09-01 |
| EP0686156A1 (en) | 1995-12-13 |
| KR960701055A (ko) | 1996-02-24 |
| ATE220677T1 (de) | 2002-08-15 |
| JPH08507056A (ja) | 1996-07-30 |
| JP3569917B2 (ja) | 2004-09-29 |
| EP0686156B1 (en) | 2002-07-17 |
| PT686156E (pt) | 2002-12-31 |
| IL108562A0 (en) | 1994-05-30 |
| MX9401408A (es) | 1994-08-31 |
| ZA94787B (en) | 1994-09-08 |
| US5670503A (en) | 1997-09-23 |
| RU2124517C1 (ru) | 1999-01-10 |
| WO1994019350A1 (en) | 1994-09-01 |
| HUT70832A (en) | 1995-11-28 |
| TW260669B (OSRAM) | 1995-10-21 |
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