DE69430988D1 - Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung - Google Patents

Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung

Info

Publication number
DE69430988D1
DE69430988D1 DE69430988T DE69430988T DE69430988D1 DE 69430988 D1 DE69430988 D1 DE 69430988D1 DE 69430988 T DE69430988 T DE 69430988T DE 69430988 T DE69430988 T DE 69430988T DE 69430988 D1 DE69430988 D1 DE 69430988D1
Authority
DE
Germany
Prior art keywords
alkyl
suitable substituent
pct
pyrazolotriazine
interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69430988T
Other languages
English (en)
Other versions
DE69430988T2 (de
Inventor
Yoshio Kawai
Hitoshi Yamazaki
Hirokazu Tanaka
Teruo Oku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE69430988D1 publication Critical patent/DE69430988D1/de
Publication of DE69430988T2 publication Critical patent/DE69430988T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69430988T 1993-02-26 1994-02-09 Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung Expired - Fee Related DE69430988T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939303993A GB9303993D0 (en) 1993-02-26 1993-02-26 New heterocyclic derivatives
PCT/JP1994/000213 WO1994019350A1 (en) 1993-02-26 1994-02-09 Pyrazolitriazines with interleukin-1 and tumour necrosis factor inhibitory activity

Publications (2)

Publication Number Publication Date
DE69430988D1 true DE69430988D1 (de) 2002-08-22
DE69430988T2 DE69430988T2 (de) 2002-11-28

Family

ID=10731142

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69430988T Expired - Fee Related DE69430988T2 (de) 1993-02-26 1994-02-09 Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung

Country Status (20)

Country Link
US (1) US5670503A (de)
EP (1) EP0686156B1 (de)
JP (1) JP3569917B2 (de)
KR (1) KR100313615B1 (de)
CN (1) CN1041929C (de)
AT (1) ATE220677T1 (de)
AU (1) AU681625B2 (de)
CA (1) CA2156919A1 (de)
DE (1) DE69430988T2 (de)
DK (1) DK0686156T3 (de)
ES (1) ES2176235T3 (de)
GB (1) GB9303993D0 (de)
HU (1) HUT70832A (de)
IL (1) IL108562A (de)
MX (1) MX9401408A (de)
PT (1) PT686156E (de)
RU (1) RU2124517C1 (de)
TW (1) TW260669B (de)
WO (1) WO1994019350A1 (de)
ZA (1) ZA94787B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2252536C (en) 1996-04-25 2010-04-06 Nissan Chemical Industries, Ltd. Ethylene derivatives and pesticides containing said derivatives
AU7726898A (en) 1997-05-22 1998-12-11 G.D. Searle & Co. Pyrazole derivatives as p38 kinase inhibitors
US6979686B1 (en) 2001-12-07 2005-12-27 Pharmacia Corporation Substituted pyrazoles as p38 kinase inhibitors
US6514977B1 (en) * 1997-05-22 2003-02-04 G.D. Searle & Company Substituted pyrazoles as p38 kinase inhibitors
CZ9904452A3 (cs) 1997-06-12 2002-02-13 Rhone-Poulenc Rorer Limited Cyklické acetaly imidazolylu, způsob jejich přípravy, jejich pouľití a farmaceutický prostředek, který je obsahuje
AU7966198A (en) 1997-06-13 1998-12-30 Smithkline Beecham Corporation Novel pyrazole and pyrazoline substituted compounds
ATE293603T1 (de) 1997-10-14 2005-05-15 Mitsubishi Pharma Corp Piperazin-verbindungen und ihre medizinische verwendung
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1112070B1 (de) * 1998-08-20 2004-05-12 Smithkline Beecham Corporation Neue substituierte triazolverbindungen
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
EP1208748A4 (de) * 1999-08-31 2002-11-20 Fujisawa Pharmaceutical Co Konservierungsmittel für organe
US6417189B1 (en) * 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
AU1782301A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
WO2001038312A1 (en) 1999-11-23 2001-05-31 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS
ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
EP1333833B1 (de) 2000-10-23 2011-08-24 GlaxoSmithKline LLC Neues trisubstitutiertes 8H-Pyrido[2,3-d]pyrimidin-7-onderivat zur Behandlung von durch CSBP/p38kinase vermittelten Krankheiten
WO2002064592A1 (en) * 2000-12-28 2002-08-22 Neurocrine Biosciences, Inc. Tricyclic crf receptor antagonists
DE60221392T2 (de) * 2001-05-24 2008-04-17 Eli Lilly And Co., Indianapolis Neue pyrrolderivate als pharmazeutische mittel
BR0309053A (pt) 2002-04-19 2005-02-22 Smithkline Beecham Corp Compostos
DE60310730T2 (de) 2002-07-09 2007-05-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
KR101050700B1 (ko) * 2002-08-26 2011-07-20 다케다 야쿠힌 고교 가부시키가이샤 칼슘 수용체 조절 화합물 및 이의 용도
DE602004030318D1 (de) 2003-01-27 2011-01-13 Merck Sharp & Dohme Substituierte pyrazole, zusammensetzungen,die solche verbindungen enthalten, und anwendungsverfahren
WO2005121097A2 (en) 2004-06-04 2005-12-22 Merck & Co., Inc. Pyrazole derivatives, compositions containing such compounds and methods of use
US20060035893A1 (en) 2004-08-07 2006-02-16 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
PE20060777A1 (es) 2004-12-24 2006-10-06 Boehringer Ingelheim Int Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
AR053346A1 (es) 2005-03-25 2007-05-02 Glaxo Group Ltd Compuesto derivado de 8h -pirido (2,3-d) pirimidin -7 ona 2,4,8- trisustituida composicion farmaceutica y uso para preparar una composicion para tratamiento y profilxis de una enfermedad mediada por la quinasa csbp/ rk/p38
TW200724142A (en) 2005-03-25 2007-07-01 Glaxo Group Ltd Novel compounds
CN101495475A (zh) 2005-03-25 2009-07-29 葛兰素集团有限公司 制备吡啶并[2,3-d]嘧啶-7-酮和3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H)-酮衍生物的方法
JP2008535822A (ja) 2005-03-25 2008-09-04 グラクソ グループ リミテッド 新規化合物
US7709658B2 (en) * 2005-07-26 2010-05-04 Merck Sharp & Dohme Corp. Process for synthesizing a substituted pyrazole
EP1992344A1 (de) 2007-05-18 2008-11-19 Institut Curie P38 Alpha als therapeutisches Target für Erkrankungen, die mit einer FGFR3- Mutation assoziiert sind
US20110195962A1 (en) * 2007-08-16 2011-08-11 Alcon Research, Ltd. Use of multi-pharmacophore compounds to treat nasal disorders
JP2010540451A (ja) * 2007-09-20 2010-12-24 ワイス・エルエルシー ピラゾロ［５，１−ｃ］［１，２，４］トリアジン、その調製法および使用法
CN101441972B (zh) 2007-11-23 2011-01-26 鸿富锦精密工业（深圳）有限公司 场发射像素管
CN101441969B (zh) 2007-11-23 2010-07-28 清华大学 场发射像素管
EP2402344A1 (de) * 2010-06-29 2012-01-04 Basf Se Pyrazolkondensierte bicyclische Verbindungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06502178A (ja) * 1990-12-31 1994-03-10 藤沢薬品工業株式会社 イミダゾトリアジン誘導体
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
IL108562A (en) 1997-06-10
IL108562A0 (en) 1994-05-30
HUT70832A (en) 1995-11-28
ES2176235T3 (es) 2002-12-01
KR100313615B1 (ko) 2002-05-30
DK0686156T3 (da) 2002-11-11
CN1041929C (zh) 1999-02-03
HU9402459D0 (en) 1994-11-28
MX9401408A (es) 1994-08-31
EP0686156B1 (de) 2002-07-17
EP0686156A1 (de) 1995-12-13
CN1120840A (zh) 1996-04-17
ATE220677T1 (de) 2002-08-15
DE69430988T2 (de) 2002-11-28
AU6010894A (en) 1994-09-14
ZA94787B (en) 1994-09-08
PT686156E (pt) 2002-12-31
WO1994019350A1 (en) 1994-09-01
RU2124517C1 (ru) 1999-01-10
KR960701055A (ko) 1996-02-24
TW260669B (de) 1995-10-21
US5670503A (en) 1997-09-23
JPH08507056A (ja) 1996-07-30
JP3569917B2 (ja) 2004-09-29
CA2156919A1 (en) 1994-09-01
GB9303993D0 (en) 1993-04-14
AU681625B2 (en) 1997-09-04

Similar Documents

Publication Publication Date Title
ATE220677T1 (de) Pyrazolotriazine mit interleukin-1 und tumor necrosis faktor inhibitor wirkung
HU9601685D0 (en) 4,5-diaryloxazole derivatives
TW262471B (de)
MX9800577A (es) Derivados de 4,5-diaril oxazol.
FI954609A (fi) 1-amidinofenyyli-pyrrolidoneja, -piperidinoneja ja -atsetinoneja verihiutaleiden kasaantumisen inhibiittoreina
AU1070895A (en) Indole-derived arylpiperazines as ligands for 5HT1-like receptors 5HT1B and 5HT1D
GB9300194D0 (en) Piperazine derivatives
GB9602029D0 (en) New heterocyclic compounds
EP0572635A4 (de) Verbindungen met Guanidin Struktur und diese enthaltende pharmazeutische Zusammenstellungen.
IL108258A0 (en) Piperazine derivates, their preparation and pharmaceutical compositions containing them
GB9313330D0 (en) New compound and its preparation
DE69330601D1 (de) Serotoninergische ergolin derivate
MX9303605A (es) Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
ATE155791T1 (de) Etoposid-derivate, ihre herstellung, ihre verwendung als medikament und ihre verwendung zur herstellung eines antikrebsmittels
ATE255102T1 (de) Benzothiophenderivate, ihre herstellung und verwendung als urokinase-inhibitoren
DK0544748T3 (da) Spiro cycloalkylbenzen-1, 1-(1,2,3,4-tetrahydroisoquinoliner) med neurobeskyttende egenskaber

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee