DK0666754T3 - Syntetisk lungesurfactant med antioxidant-egenskaber - Google Patents

Syntetisk lungesurfactant med antioxidant-egenskaber

Info

Publication number
DK0666754T3
DK0666754T3 DK92921892T DK92921892T DK0666754T3 DK 0666754 T3 DK0666754 T3 DK 0666754T3 DK 92921892 T DK92921892 T DK 92921892T DK 92921892 T DK92921892 T DK 92921892T DK 0666754 T3 DK0666754 T3 DK 0666754T3
Authority
DK
Denmark
Prior art keywords
antioxidant properties
lung surfactant
synthetic lung
surfactants
synthetic
Prior art date
Application number
DK92921892T
Other languages
Danish (da)
English (en)
Inventor
Larry R Mclean
Marguerite H Payne
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0666754T3 publication Critical patent/DK0666754T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK92921892T 1991-11-04 1992-10-13 Syntetisk lungesurfactant med antioxidant-egenskaber DK0666754T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/789,918 US5272252A (en) 1991-11-04 1991-11-04 Synthetic lung surfactant having antioxidant properties
PCT/US1992/008728 WO1993008824A1 (en) 1991-11-04 1992-10-13 Synthetic lung surfactant having antioxidant properties

Publications (1)

Publication Number Publication Date
DK0666754T3 true DK0666754T3 (da) 1999-08-30

Family

ID=25149105

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92921892T DK0666754T3 (da) 1991-11-04 1992-10-13 Syntetisk lungesurfactant med antioxidant-egenskaber

Country Status (15)

Country Link
US (2) US5272252A (de)
EP (1) EP0666754B1 (de)
JP (1) JPH07502500A (de)
KR (1) KR100250847B1 (de)
AT (1) ATE175116T1 (de)
AU (1) AU667200B2 (de)
CA (1) CA2121147C (de)
DE (1) DE69228077T2 (de)
DK (1) DK0666754T3 (de)
ES (1) ES2127764T3 (de)
FI (1) FI942032A0 (de)
GR (1) GR3029279T3 (de)
HU (1) HUT66424A (de)
NO (1) NO941616D0 (de)
WO (1) WO1993008824A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5653685A (en) * 1990-10-10 1997-08-05 Lrt, Inc. Method of providing circulation via lung expansion and deflation
USRE36460E (en) * 1990-10-10 1999-12-21 Life Science Holdings, Inc. Method of providing circulation via lung expansion and deflation
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU664112B2 (en) * 1992-07-31 1995-11-02 Merrell Dow Pharmaceuticals Inc. Synthetic peptide lung surfactants having covalently bonded antioxidants
JP3856343B2 (ja) * 1995-11-20 2006-12-13 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド 肺胞界面活性物質ペプチドの可溶化法
WO1997032621A1 (en) * 1996-03-08 1997-09-12 Life Resuscitation Technologies, Inc. Liquid ventilation method and apparatus
AU2001278864A1 (en) * 2000-06-30 2002-01-30 University Of Cincinnati Peptides with antioxidant and antimicrobial properties
GB2368339B (en) * 2000-10-26 2002-09-18 Yissum Res Dev Co Complex incorporating a plurality of antioxidants
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
IL164795A0 (en) * 2002-04-25 2005-12-18 Scripps Research Inst Treatment and prevention of pulmonary conditions
US7290197B2 (en) * 2003-06-03 2007-10-30 Quantum Corporation Correcting data using redundancy blocks
EP1809272A4 (de) * 2004-10-18 2008-01-02 Maroon Biotech Corp Verfahren und zusammensetzungen zur behandlung von schäden durch freie radikale
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
CA2593758A1 (en) 2005-01-06 2006-07-13 Discovery Laboratories, Inc. Surfactant treatment regimen for treating or preventing bronchopulmonary dysplasia
US20110195892A1 (en) * 2005-06-29 2011-08-11 Sannamu Lee Artifical Pulmonary Surfactant Compositions
MX2009003002A (es) * 2006-09-19 2009-06-01 Discovery Lab Inc Formulaciones de tensioactivos pulmonares y metodos para promover la aclaracion del moco.
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
CN111568853B (zh) * 2020-04-30 2023-07-28 杭州濡湜生物科技有限公司 一种新型肺部智能释药系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643988A (en) * 1984-05-15 1987-02-17 Research Corporation Amphipathic peptides
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4705684A (en) * 1985-05-31 1987-11-10 The University Of Tennessee Research Corporation Synthetic M proteins - streptococci type 6
FR2586587B1 (fr) * 1985-08-30 1987-10-23 Adir Nouveaux surfactants artificiels, leur preparation et les compositions pharmaceutiques qui les contiennent.
US4882422A (en) * 1985-10-24 1989-11-21 Genetics Institute, Inc. Pulmonary surfactant proteins
US4918161A (en) * 1985-09-26 1990-04-17 Genetics Institute, Inc. Low molecular weight pulmonary surfactant proteins
US5055553A (en) * 1985-09-26 1991-10-08 Genetics Institute Inc. Low molecular weight pulmonary surfactant proteins
JPS63503222A (ja) * 1986-05-06 1988-11-24 サイオス　ノバ　インコーポレイテッド 肺の疎水性界面活性物質に結合した分子量６，０００ダルトンのタンパク質及びその多量体
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
JPH01501282A (ja) * 1986-12-08 1989-05-11 ホイツトセツト，ジエフリー　エイ． 肺胞疎水性界面活性物質関連タンパク質
WO1989000167A1 (en) * 1987-07-01 1989-01-12 Kabigen Ab Proteins and protein compositions and their use
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
US5164369A (en) * 1988-01-06 1992-11-17 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
AR245141A1 (es) * 1988-07-01 1993-12-30 Merrell Dow Pharma Procedimiento de sintesis secuencial o de bloques en fase solida para preparar polipeptidos de estructura helicoidal.
SE8803713D0 (sv) * 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
US5134129A (en) * 1989-03-15 1992-07-28 Board Of Regents, The University Of Texas System Methods employing unique mixtures of polar and neutral lipids for surfactant replacement therapy
JPH04504255A (ja) * 1989-03-31 1992-07-30 ジェネンテク，インコーポレイテッド 呼吸困難症候群の治療法
EP0458167B1 (de) * 1990-05-21 1997-04-23 Abbott Laboratories Fettsäure-Oberflächenaktives-Lungenprotein Konjate
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties

Also Published As

Publication number Publication date
ATE175116T1 (de) 1999-01-15
EP0666754A4 (de) 1996-06-26
CA2121147C (en) 2002-12-10
DE69228077T2 (de) 1999-07-08
WO1993008824A1 (en) 1993-05-13
ES2127764T3 (es) 1999-05-01
GR3029279T3 (en) 1999-05-28
EP0666754A1 (de) 1995-08-16
FI942032A (fi) 1994-05-03
NO941616L (de) 1994-06-24
AU667200B2 (en) 1996-03-14
AU2778392A (en) 1993-06-07
JPH07502500A (ja) 1995-03-16
US5272252A (en) 1993-12-21
KR100250847B1 (ko) 2000-09-01
US5683982A (en) 1997-11-04
HU9401293D0 (en) 1994-08-29
FI942032A0 (fi) 1994-05-03
CA2121147A1 (en) 1993-05-13
HUT66424A (en) 1994-11-28
EP0666754B1 (de) 1998-12-30
DE69228077D1 (de) 1999-02-11
NO941616D0 (no) 1994-05-03

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