DK0643699T3 - 6-(2-hydroxyethylaminoalkyl)-5,11-dioxo-5,6-dihydro-11H-indeno(1,2-c)isoquinoliner og deres anvendelse som antineoplastiske midler - Google Patents

6-(2-hydroxyethylaminoalkyl)-5,11-dioxo-5,6-dihydro-11H-indeno(1,2-c)isoquinoliner og deres anvendelse som antineoplastiske midler

Info

Publication number
DK0643699T3
DK0643699T3 DK92920015.2T DK92920015T DK0643699T3 DK 0643699 T3 DK0643699 T3 DK 0643699T3 DK 92920015 T DK92920015 T DK 92920015T DK 0643699 T3 DK0643699 T3 DK 0643699T3
Authority
DK
Denmark
Prior art keywords
indeno
derivatives
dioxo
dihydro
indenoisochinoline
Prior art date
Application number
DK92920015.2T
Other languages
Danish (da)
English (en)
Inventor
Jiri Hrbata
Jir I Krepelka
Milan Melka
Milan Miko
Milan Hruby
Milan Ferenc
Eva Skacelova
Irena Kejhova
Ruzena Reichlova
Anna Kargerova
Jitka Sediva
Alois Kolonicny
Josef Urbanec
Jiri Michalsky
Original Assignee
Vufb As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vufb As filed Critical Vufb As
Application granted granted Critical
Publication of DK0643699T3 publication Critical patent/DK0643699T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK92920015.2T 1991-08-29 1992-08-27 6-(2-hydroxyethylaminoalkyl)-5,11-dioxo-5,6-dihydro-11H-indeno(1,2-c)isoquinoliner og deres anvendelse som antineoplastiske midler DK0643699T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS912669A CZ281473B6 (cs) 1991-08-29 1991-08-29 Deriváty 6-/X-(2-hydroxyethyl)aminoalkyl/-5,11 -dioxo-5,6-dihydro-11H-indeno/1,2-c/-isochinolinu a způsob jejich výroby

Publications (1)

Publication Number Publication Date
DK0643699T3 true DK0643699T3 (da) 1997-04-28

Family

ID=5364459

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92920015.2T DK0643699T3 (da) 1991-08-29 1992-08-27 6-(2-hydroxyethylaminoalkyl)-5,11-dioxo-5,6-dihydro-11H-indeno(1,2-c)isoquinoliner og deres anvendelse som antineoplastiske midler

Country Status (15)

Country Link
EP (1) EP0643699B1 (fr)
JP (1) JPH07500581A (fr)
AT (1) ATE144499T1 (fr)
AU (1) AU663729B2 (fr)
CA (1) CA2116680A1 (fr)
CZ (1) CZ281473B6 (fr)
DE (1) DE69214842T2 (fr)
DK (1) DK0643699T3 (fr)
FI (1) FI107256B (fr)
HU (1) HU217551B (fr)
NO (1) NO180194C (fr)
PL (1) PL169572B1 (fr)
RU (1) RU2120939C1 (fr)
SK (1) SK266991A3 (fr)
WO (1) WO1993005023A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3141148B2 (ja) * 1995-08-08 2001-03-05 大鵬薬品工業株式会社 縮合インダン誘導体及びその塩
US6509344B1 (en) * 1998-10-14 2003-01-21 The United States Of America As Represented By The Department Of Health And Human Services Indenoisoquinolines as antineoplastic agents
US20030096833A1 (en) 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof
US6956035B2 (en) 2001-08-31 2005-10-18 Inotek Pharmaceuticals Corporation Isoquinoline derivatives and methods of use thereof
CN100398519C (zh) * 2003-02-28 2008-07-02 伊诺泰克制药公司 四环苯甲酰胺衍生物及其用法
KR20060125909A (ko) 2004-02-26 2006-12-06 이노텍 파마슈티컬스 코포레이션 이소퀴놀린 유도체 및 이의 사용 방법
WO2006093667A1 (fr) 2005-02-25 2006-09-08 Inotek Pharmaceuticals Corporation Composes amino et carboxamido tetracycliques et procedes d'utilisation associes
EP1937268A4 (fr) 2005-08-24 2009-07-22 Inotek Pharmaceuticals Corp Analogues d'indenoisoquinolinone et leurs procedes d'utilisation
CN101674832A (zh) 2007-02-28 2010-03-17 伊诺泰克制药公司 茚并异喹啉酮类似物及其使用方法
CN102250000A (zh) * 2010-05-17 2011-11-23 中国人民解放军第二军医大学 茚并喹啉酮类化合物及其制备方法和用途
TWI642658B (zh) * 2017-11-01 2018-12-01 國立臺灣師範大學 茚並異喹啉衍生物的製備方法

Also Published As

Publication number Publication date
NO940542L (no) 1994-02-17
DE69214842T2 (de) 1997-02-27
NO180194C (no) 1997-03-05
HU9400563D0 (en) 1994-05-30
WO1993005023A1 (fr) 1993-03-18
CZ266991A3 (en) 1993-03-17
ATE144499T1 (de) 1996-11-15
EP0643699B1 (fr) 1996-10-23
AU2583592A (en) 1993-04-05
FI940895A0 (fi) 1994-02-25
HUT70396A (en) 1995-10-30
PL169572B1 (pl) 1996-08-30
JPH07500581A (ja) 1995-01-19
FI107256B (fi) 2001-06-29
AU663729B2 (en) 1995-10-19
CZ281473B6 (cs) 1996-10-16
SK278794B6 (sk) 1998-03-04
DE69214842D1 (de) 1996-11-28
NO940542D0 (no) 1994-02-17
SK266991A3 (en) 1998-03-04
EP0643699A1 (fr) 1995-03-22
FI940895A (fi) 1994-02-25
CA2116680A1 (fr) 1993-03-18
NO180194B (no) 1996-11-25
HU217551B (hu) 2000-02-28
RU2120939C1 (ru) 1998-10-27

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