DK0641343T3 - 4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer - Google Patents

4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer

Info

Publication number
DK0641343T3
DK0641343T3 DK93912116T DK93912116T DK0641343T3 DK 0641343 T3 DK0641343 T3 DK 0641343T3 DK 93912116 T DK93912116 T DK 93912116T DK 93912116 T DK93912116 T DK 93912116T DK 0641343 T3 DK0641343 T3 DK 0641343T3
Authority
DK
Denmark
Prior art keywords
mercaptoacetylamino
benzazepinone
derivatives
enkephalinase inhibitors
enkephalinase
Prior art date
Application number
DK93912116T
Other languages
Danish (da)
English (en)
Inventor
Gary A Flynn
Alan M Warshawsky
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of DK0641343T3 publication Critical patent/DK0641343T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK93912116T 1992-05-20 1993-04-06 4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer DK0641343T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/886,029 US5238932A (en) 1992-05-20 1992-05-20 Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
PCT/US1993/003150 WO1993023397A1 (en) 1992-05-20 1993-04-06 4-mercaptoacetylamino-[2] benzazepinone(3) derivatives, and use as enkephalinase inhibitors

Publications (1)

Publication Number Publication Date
DK0641343T3 true DK0641343T3 (da) 2003-10-13

Family

ID=25388225

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93912116T DK0641343T3 (da) 1992-05-20 1993-04-06 4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer

Country Status (20)

Country Link
US (1) US5238932A (enExample)
EP (1) EP0641343B1 (enExample)
JP (1) JP3295848B2 (enExample)
KR (1) KR100281608B1 (enExample)
AT (1) ATE243694T1 (enExample)
AU (1) AU669716B2 (enExample)
CA (1) CA2135751C (enExample)
DE (1) DE69333062T2 (enExample)
DK (1) DK0641343T3 (enExample)
ES (1) ES2201058T3 (enExample)
FI (1) FI108136B (enExample)
HU (1) HUT71107A (enExample)
IL (1) IL105727A (enExample)
MX (1) MX9302906A (enExample)
NO (1) NO302366B1 (enExample)
NZ (1) NZ252785A (enExample)
PT (1) PT641343E (enExample)
TW (1) TW269682B (enExample)
WO (1) WO1993023397A1 (enExample)
ZA (1) ZA933423B (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430145A (en) * 1990-10-18 1995-07-04 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5308841A (en) * 1990-12-21 1994-05-03 Merrell Dow Pharmaceuticals Inc. Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
EP0534363B1 (en) * 1991-09-27 1997-07-09 Merrell Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5457196A (en) * 1991-09-27 1995-10-10 Merrell Dow Pharmaceuticals Inc. 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
CA2078759C (en) * 1991-09-27 2003-09-16 Alan M. Warshawsky Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
WO1993016103A1 (en) * 1992-02-14 1993-08-19 Merrell Dow Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5420271A (en) * 1992-08-24 1995-05-30 Merrell Dow Pharmaceuticals, Inc. 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
CA2146238C (en) * 1992-10-30 2001-03-13 Gary A. Flynn Novel mercaptoacetylamide bicyclic lactam derivatives useful as inhibitors of enkephalinase and ace
JP3563738B2 (ja) * 1993-06-11 2004-09-08 エーザイ株式会社 アミノ酸誘導体
AU680512B2 (en) * 1993-06-11 1997-07-31 Eisai Co. Ltd. Amino acid derivative
US5530013A (en) * 1994-02-14 1996-06-25 American Home Products Corporation Venlafaxine in the inducement of cognition enhancement
HUT74584A (en) * 1994-02-14 1997-01-28 Merrell Pharma Inc Novel heterocycle fused benzazepine-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase, process for producing them and pharmaceutical compositions containing them
CN1142831A (zh) * 1994-02-14 1997-02-12 默里尔药物公司 用作脑啡肽酶和ace抑制剂的新的2-取代的1，2-二氢化茚-2-巯基乙酰胺二硫化物衍生物
ES2131806T3 (es) * 1994-02-14 1999-08-01 Merrell Pharma Inc Nuevos derivados de disulfuro de mercaptoacetilamida utiles como inhibidores de encefalinasa y ace.
HUT74385A (en) * 1994-02-14 1996-12-30 Merrell Pharma Inc Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
US5484783A (en) * 1994-03-24 1996-01-16 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
HUT75160A (en) * 1994-03-24 1997-04-28 Merrell Pharma Inc Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives
CN1144482A (zh) * 1994-03-24 1997-03-05 默里尔药物公司 降低胆固醇、抗动脉粥样硬化和降低甘油三酯的巯基乙酰胺二硫化物衍生物
ATE266040T1 (de) * 1994-12-21 2004-05-15 Aventis Pharma Inc Verfahren zur herstellung von zwischenprodukten von inhibitoren von enkephalinase und angiotensin konvertierendem enzym und zwischenprodukte davon
US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
IT1298268B1 (it) * 1998-02-18 1999-12-20 Zambon Spa Procedimento per la preparazione dell'acido (s)-2-bromo-3-fenil- propionico
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) * 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) * 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
CA2363847A1 (en) * 1999-01-12 2000-07-20 Kenneth Blum Treatment of hypertension with compounds that inhibit the destruction of enkephalins or endorphins
WO2001068674A2 (en) * 2000-03-13 2001-09-20 Monsanto Technology Llc Preparation of recombinant proteins containing repeating units
GB0119305D0 (en) 2001-04-12 2001-10-03 Aventis Pharma Gmbh Mercaptoacetylamide derivatives,a process for their preparation and their use
US20050192265A1 (en) * 2003-03-20 2005-09-01 Thompson Richard C. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
CN116535304B (zh) * 2023-03-31 2024-07-19 中国科学院成都生物研究所 毛兰素类似物及其合成方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
JPH0678531B2 (ja) * 1986-06-11 1994-10-05 株式会社日立製作所 石炭ガス化方法及び装置
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
ZA874107B (enExample) * 1986-06-13 1987-12-09
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
AU7168091A (en) * 1989-12-22 1991-07-24 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Also Published As

Publication number Publication date
HUT71107A (en) 1995-11-28
KR950701632A (ko) 1995-04-28
HU9403323D0 (en) 1995-02-28
IL105727A (en) 2000-11-21
JPH07506827A (ja) 1995-07-27
FI945434L (fi) 1994-11-18
WO1993023397A1 (en) 1993-11-25
KR100281608B1 (ko) 2001-02-15
CA2135751C (en) 1999-09-21
JP3295848B2 (ja) 2002-06-24
MX9302906A (es) 1993-11-01
ATE243694T1 (de) 2003-07-15
IL105727A0 (en) 1993-09-22
AU4277993A (en) 1993-12-13
DE69333062D1 (de) 2003-07-31
NO944430D0 (no) 1994-11-18
ZA933423B (en) 1993-12-08
PT641343E (pt) 2003-10-31
NZ252785A (en) 1995-11-27
NO302366B1 (no) 1998-02-23
FI108136B (fi) 2001-11-30
FI945434A0 (fi) 1994-11-18
DE69333062T2 (de) 2004-05-06
CA2135751A1 (en) 1993-11-25
US5238932A (en) 1993-08-24
EP0641343A1 (en) 1995-03-08
ES2201058T3 (es) 2004-03-16
NO944430L (no) 1995-01-17
TW269682B (enExample) 1996-02-01
EP0641343B1 (en) 2003-06-25
AU669716B2 (en) 1996-06-20

Similar Documents

Publication Publication Date Title
DK0641343T3 (da) 4-Mercaptoacetylamino-[2]benzazepinon(3)-derivater og anvendelse som enkefalinaseinhibitorer
IL99769A0 (en) Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
NO942994D0 (no) Aminoacetylmercaptoacetylamidderivater som er anvendbare som inhibitorer av enkefalinase og ACE
IL103283A0 (en) Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace
MX9205432A (es) Compuestos inhibidores de la biosintesis de leucotrienos y composicion farmaceutica que los contiene.
BR9403948A (pt) Composição de matéria
BR9403946A (pt) Composição de matéria
FI963169L (fi) Enkefalinaasin ja ACE:n inhibittoreina käyttökelpoisia uusia merkaptoasetyyliamido-1,3,4,5-tetrahydrobents/c/-atsepin-3-onidisulfidijohdannaisia
FI952014L (fi) Uusia bisyklisiä merkaptoasetyyliamidilaktaamijohdannaisia, jotka ovat hyödyllisiä enkefalinaasin ja ACE:n inhibiittoreina
ZA936059B (en) Novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
FI950842L (fi) Enkefalinaasin inhibiittoreina käyttökelpoisia uusia 2-substituoituja trisyklisiä indaani-2-merkaptoasetyyliamidijohdannaisia
FI962235L (fi) Uudet bentseenisulfonyyli-imiinijohdannaiset IL-1:n toiminnan inhibiittoreina
KR950014181U (ko) 포장용 깡통 꼭지쇠의 구조
KR950015546U (ko) 브라운관의 고정장치
SE9301267D0 (sv) Emballeringsmetod
ITMI931727A0 (it) Derivati di 5-isochinolinsolfonammidi
ITMI930345A1 (it) N-acil-peptidi inibitori delle protein-chinasi
GR1001368B (el) Φαρμακευτικοί φορείς.
KR940025679U (ko) 액정표시 장치의 고정장치
BR7200513U (pt) Disposicao construtiva aperfeicoada de aiveca