DK0624596T3 - Tetrazolderivater af galdesyrer, fremgangsmåde tilderes fremstilling og anvendelse af disse forbindelser som lægemidler - Google Patents

Tetrazolderivater af galdesyrer, fremgangsmåde tilderes fremstilling og anvendelse af disse forbindelser som lægemidler

Info

Publication number
DK0624596T3
DK0624596T3 DK94106848T DK94106848T DK0624596T3 DK 0624596 T3 DK0624596 T3 DK 0624596T3 DK 94106848 T DK94106848 T DK 94106848T DK 94106848 T DK94106848 T DK 94106848T DK 0624596 T3 DK0624596 T3 DK 0624596T3
Authority
DK
Denmark
Prior art keywords
compounds
preparation
drugs
bile acids
tetrazole derivatives
Prior art date
Application number
DK94106848T
Other languages
Danish (da)
English (en)
Inventor
Heiner Dr Glombik
Alfons Dr Enhsen
Werner Dr Dr Kramer
Guenter Dr Wess
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Application granted granted Critical
Publication of DK0624596T3 publication Critical patent/DK0624596T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK94106848T 1993-05-08 1994-05-02 Tetrazolderivater af galdesyrer, fremgangsmåde tilderes fremstilling og anvendelse af disse forbindelser som lægemidler DK0624596T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4315368 1993-05-08

Publications (1)

Publication Number Publication Date
DK0624596T3 true DK0624596T3 (da) 1998-10-07

Family

ID=6487579

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94106848T DK0624596T3 (da) 1993-05-08 1994-05-02 Tetrazolderivater af galdesyrer, fremgangsmåde tilderes fremstilling og anvendelse af disse forbindelser som lægemidler

Country Status (19)

Country Link
US (1) US5466815A (sh)
EP (1) EP0624596B1 (sh)
JP (1) JP3476157B2 (sh)
KR (1) KR100333149B1 (sh)
AT (1) ATE163938T1 (sh)
AU (1) AU666440B2 (sh)
CA (1) CA2123048C (sh)
CY (1) CY2119B1 (sh)
CZ (1) CZ289515B6 (sh)
DE (1) DE59405410D1 (sh)
DK (1) DK0624596T3 (sh)
ES (1) ES2115096T3 (sh)
FI (1) FI942075A (sh)
GR (1) GR3026496T3 (sh)
HU (1) HU217439B (sh)
IL (1) IL109581A (sh)
NO (1) NO304795B1 (sh)
NZ (1) NZ260469A (sh)
TW (1) TW289757B (sh)

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RU2017118569A (ru) 2014-11-06 2018-12-06 Энанта Фармасьютикалс, Инк. Аналоги желчных кислот как агонисты fxr/tgr5 и способы их применения
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CN107250150B (zh) * 2015-04-28 2019-11-22 江苏豪森药业集团有限公司 胆酸衍生物及其制备方法和医药用途
US10441605B2 (en) 2016-02-09 2019-10-15 Albireo Ab Oral cholestyramine formulation and use thereof
ES2874546T3 (es) 2016-02-09 2021-11-05 Albireo Ab Formulación oral de colestiramina y uso de la misma
US10441604B2 (en) 2016-02-09 2019-10-15 Albireo Ab Cholestyramine pellets and methods for preparation thereof
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BR112022010505A2 (pt) 2019-12-04 2022-09-06 Albireo Ab Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar
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TW202134222A (zh) 2019-12-04 2021-09-16 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯化合物及其作為膽酸調節劑之用途
CN116157389A (zh) 2020-08-03 2023-05-23 阿尔比里奥公司 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
WO2022029101A1 (en) 2020-08-03 2022-02-10 Albireo Ab Benzothia(di)azepine compounds and their use as bile acid modulators
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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DE3930696A1 (de) * 1989-09-14 1991-03-28 Hoechst Ag Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel
ES2096614T3 (es) * 1990-12-06 1997-03-16 Hoechst Ag Derivados de acidos biliares, procedimiento para su preparacion y utilizacion de este compuesto como medicamento.

Also Published As

Publication number Publication date
DE59405410D1 (de) 1998-04-16
FI942075A (fi) 1994-11-09
NO941677D0 (no) 1994-05-06
NZ260469A (en) 1995-03-28
IL109581A (en) 1998-03-10
CA2123048A1 (en) 1994-11-09
JPH06329695A (ja) 1994-11-29
IL109581A0 (en) 1994-08-26
AU666440B2 (en) 1996-02-08
HUT67390A (en) 1995-04-28
US5466815A (en) 1995-11-14
CA2123048C (en) 2005-11-29
FI942075A0 (fi) 1994-05-05
EP0624596A2 (de) 1994-11-17
HU9401443D0 (en) 1994-08-29
CZ289515B6 (cs) 2002-02-13
GR3026496T3 (en) 1998-07-31
CY2119B1 (en) 2002-04-26
NO304795B1 (no) 1999-02-15
EP0624596A3 (de) 1995-06-07
CZ113594A3 (en) 1994-12-15
JP3476157B2 (ja) 2003-12-10
ATE163938T1 (de) 1998-03-15
HU217439B (hu) 2000-01-28
TW289757B (sh) 1996-11-01
ES2115096T3 (es) 1998-06-16
EP0624596B1 (de) 1998-03-11
KR100333149B1 (ko) 2002-09-19
AU6194794A (en) 1994-11-10
NO941677L (no) 1994-11-09

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