DK0621073T3 - Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf - Google Patents

Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf

Info

Publication number
DK0621073T3
DK0621073T3 DK94200884.8T DK94200884T DK0621073T3 DK 0621073 T3 DK0621073 T3 DK 0621073T3 DK 94200884 T DK94200884 T DK 94200884T DK 0621073 T3 DK0621073 T3 DK 0621073T3
Authority
DK
Denmark
Prior art keywords
nanocapsules
stability
increasing
during storage
temperature
Prior art date
Application number
DK94200884.8T
Other languages
English (en)
Inventor
Valdivia Francisco Javie Galan
Dachs Anna Coll
Perdiguer Nuria Carreras
Original Assignee
Alcon Cusi S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Cusi S A filed Critical Alcon Cusi S A
Application granted granted Critical
Publication of DK0621073T3 publication Critical patent/DK0621073T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/203—Exchange of core-forming material by diffusion through the capsule wall
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/701—Integrated with dissimilar structures on a common substrate
    • Y10S977/715—On an organic substrate
    • Y10S977/717—Lipid substrate
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
DK94200884.8T 1993-04-20 1994-03-30 Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf DK0621073T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09300827A ES2070076B1 (es) 1993-04-20 1993-04-20 Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.

Publications (1)

Publication Number Publication Date
DK0621073T3 true DK0621073T3 (da) 1998-06-02

Family

ID=8281529

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94200884.8T DK0621073T3 (da) 1993-04-20 1994-03-30 Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf

Country Status (8)

Country Link
US (1) US5885491A (da)
EP (1) EP0621073B1 (da)
JP (1) JPH0815550B2 (da)
AT (1) ATE159186T1 (da)
DE (1) DE69406178T2 (da)
DK (1) DK0621073T3 (da)
ES (1) ES2070076B1 (da)
GR (1) GR3025888T3 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10008305A1 (de) * 2000-02-23 2001-09-06 Henkel Kgaa Mittel zur Reinigung und Pflege von Haut und/oder Haaren
FR2805761B1 (fr) * 2000-03-02 2002-08-30 Mainelab Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US20060286064A1 (en) * 2000-08-30 2006-12-21 Medivas, Llc Therapeutic polymers and methods
CN1558755A (zh) * 2001-09-26 2004-12-29 ���ع��ʹ�˾ 通过分散和除去溶剂或液相制备亚微米大小的纳米颗粒
US7112340B2 (en) * 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
JP2007522085A (ja) * 2003-06-27 2007-08-09 スミスクライン・ビーチャム・コーポレイション 安定化されたトポテカンリポソーム組成物および方法
JP5178520B2 (ja) * 2005-09-22 2013-04-10 メディバス エルエルシー 固体ポリマー送達組成物およびその使用法
EP1926780B1 (en) 2005-09-22 2013-08-14 Medivas, LLC Bis-( -amino)-diol-diester-containing poly(ester amide) and poly(ester urethane) compositions and methods of use
JP2009524584A (ja) * 2005-12-07 2009-07-02 メディバス エルエルシー ポリマー−生物製剤送達組成物を構築するための方法
WO2007130477A2 (en) * 2006-05-02 2007-11-15 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
US20070282011A1 (en) * 2006-05-09 2007-12-06 Medivas, Llc Biodegradable water soluble polymers
JP2010502822A (ja) * 2006-09-05 2010-01-28 メディバス エルエルシー ポリマー安定化リポソーム組成物および使用方法
US20090029937A1 (en) * 2007-07-24 2009-01-29 Cornell University Biodegradable cationic polymer gene transfer compositions and methods of use
JP2012500207A (ja) * 2008-08-13 2012-01-05 メディバス エルエルシー Ａａｂｂ−ポリ（デプシペプチド）生分解性ポリマー及び使用方法
JP2011241147A (ja) * 2008-08-29 2011-12-01 Nano Egg:Kk インドメタシン含有ナノカプセルおよびその製造方法
US8666685B2 (en) 2011-04-19 2014-03-04 Schneider Electronic IT Corporation System of intelligent sensors in an electrical panelboard
US8660810B2 (en) 2011-04-19 2014-02-25 Schneider Electric It Corporation System and method to calculate RMS current and true power in a multidrop sensor network
EP4406558A3 (en) 2011-06-23 2024-10-23 DSM IP Assets B.V. New biodegradable polyesteramide copolymers for drug delivery
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US10434071B2 (en) 2014-12-18 2019-10-08 Dsm Ip Assets, B.V. Drug delivery system for delivery of acid sensitivity drugs
US11147811B2 (en) * 2016-03-10 2021-10-19 Sumitomo Dainippon Pharma Co., Ltd. Composition comprising fine particle and process thereof
WO2021094468A1 (en) 2019-11-12 2021-05-20 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2416008A1 (fr) * 1978-02-02 1979-08-31 Oreal Lyophilisats de liposomes
JPS57147430A (en) * 1981-03-06 1982-09-11 Kureha Chem Ind Co Ltd Preparation of microcapsule
FR2515960A1 (fr) * 1981-11-06 1983-05-13 Alkhouri Fallouh Nazir Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
CA1285491C (en) * 1985-09-12 1991-07-02 Robert J. Smith Method of treating catabolic dysfunction
US4806343A (en) * 1986-03-13 1989-02-21 University Of Southwestern Louisiana Cryogenic protectant for proteins
US5204112A (en) * 1986-06-16 1993-04-20 The Liposome Company, Inc. Induction of asymmetry in vesicles
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
US5093198A (en) * 1987-06-19 1992-03-03 Temple University Adjuvant-enhanced sustained release composition and method for making
JP3226300B2 (ja) * 1990-07-18 2001-11-05 エーザイ株式会社 プロナノスフィア及びその製造方法
KR930006431B1 (ko) * 1990-10-11 1993-07-16 재단법인 한국화학연구소 약물의 미세캡슐화 방법
US5250236A (en) * 1991-08-05 1993-10-05 Gasco Maria R Method for producing solid lipid microspheres having a narrow size distribution
FR2692168B1 (fr) * 1992-06-16 1995-03-24 Centre Nat Rech Scient Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles

Also Published As

Publication number Publication date
EP0621073B1 (en) 1997-10-15
JPH06343854A (ja) 1994-12-20
US5885491A (en) 1999-03-23
JPH0815550B2 (ja) 1996-02-21
ES2070076A1 (es) 1995-05-16
DE69406178D1 (de) 1997-11-20
DE69406178T2 (de) 1998-06-04
HK1011943A1 (en) 1999-07-23
EP0621073A1 (en) 1994-10-26
GR3025888T3 (en) 1998-04-30
ATE159186T1 (de) 1997-11-15
ES2070076B1 (es) 1996-04-16

Similar Documents

Publication Publication Date Title
DK0621073T3 (da) Fremgangsmåde til forøgelse af stabiliteten af nanokapsler under opbevaring deraf
DE59109210D1 (de) Verfahren zur Herstellung von Wasseradsorptionsmaterial und dessen Verwendung in Hygieneartikeln und zur Bodenverbesserung
DE3783741D1 (de) Karrageenan enthaltendes waessriges gel.
ATE36447T1 (de) Bindung von fluechtigen stoffen auf einem amorphen substrat und die so erhaltenen produkte.
ATE106774T1 (de) Verfahren zur herstellung von wasserabsorptionsmaterial auf polymerbasis und dessen verwendung.
NO180801C (no) Fremgangsmåte til fremstilling av et frysetörket preparat
CA2074162A1 (en) Composition to improve survival of biological materials
ATE27446T1 (de) Verfahren zur herstellung von 1,2,3-trichlor-2methyl-propan.
SE8301795L (sv) Plasminogenaktivatorkomplex
AU2673688A (en) Method of producing free flowing beads of biological materials and method for their application to the leaf surface of plants
DE3584610D1 (de) Lebende mikroorganismen enthaltendes fluessiges praeparat, verfahren zu dessen herstellung, lebende mikroorganismen enthaltendes pelletiertes produkt und verfahren zu dessen herstellung.
WO1998007328A3 (en) Ultra-short heat treatment method for a liquid
IT7825713A0 (it) Derivati d'acido ciclopropancarbossilico, processo per la loro produzione e loro impiego come prodotti per laproduzione d'insetticidi.
DE59206398D1 (de) Verfahren zur Herstellung von 1-Carbamoyl-pyrazolen
AU526532B2 (en) Aqueous dispersions of polymers
ATE16393T1 (de) Verfahren zur herstellung von chlor-phenylphosphanen.
BR9911255A (pt) Processo para a preparação de agente espessante, material particulado, e, processo para espessamento de produto alimentìcio lìquido
JPS55161801A (en) Fluorescence-labeled acid mucopolysaccharide and preparation thereof
Vol'kenshteĭn et al. Electronic-conformational interactions of molecular-biological systems. I. Quantum-chemical aspect of the theory of electronic-conformational interaction
TH17769A (th) วิธีการผลิตโปรทีนไฮโดรไลเซท
BR9006935A (pt) Composicao liquida,composicao fumigante de solo liquida,processo para tratamento de solo,processo para tratamento de plantas,processo para tratamento de arvores,composicao solida e processo de aplicacao
Kaiser et al. Ecological investigations in the onshore pelagic zone near Warnemuende from March 1985 to March 1986.
JPS55123635A (en) Production of nonsoluble molding of high polymer
DE59404408D1 (de) Verfahren zur Herstellung von Isocyansäure aus Cyanursäure
DE59807906D1 (de) Verfahren zur Herstellung von bissfesten Früchten