DK0603992T4 - Oral indgivelse af immunologisk aktive biomolekyler og andre terapeutiske proteiner - Google Patents
Oral indgivelse af immunologisk aktive biomolekyler og andre terapeutiske proteinerInfo
- Publication number
- DK0603992T4 DK0603992T4 DK93300005T DK93300005T DK0603992T4 DK 0603992 T4 DK0603992 T4 DK 0603992T4 DK 93300005 T DK93300005 T DK 93300005T DK 93300005 T DK93300005 T DK 93300005T DK 0603992 T4 DK0603992 T4 DK 0603992T4
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- therapeutic protein
- orally
- oral administration
- stabilizing agent
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 230000001225 therapeutic effect Effects 0.000 title abstract 5
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99493292A | 1992-12-22 | 1992-12-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
DK0603992T3 DK0603992T3 (da) | 1997-03-24 |
DK0603992T4 true DK0603992T4 (da) | 2001-03-05 |
Family
ID=25541237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK93300005T DK0603992T4 (da) | 1992-12-22 | 1993-01-04 | Oral indgivelse af immunologisk aktive biomolekyler og andre terapeutiske proteiner |
Country Status (12)
Country | Link |
---|---|
US (1) | US5591433A (ja) |
EP (1) | EP0603992B2 (ja) |
JP (1) | JPH0710771A (ja) |
AT (1) | ATE143803T1 (ja) |
AU (1) | AU664222B2 (ja) |
CA (1) | CA2086631C (ja) |
DE (1) | DE69305313T3 (ja) |
DK (1) | DK0603992T4 (ja) |
ES (1) | ES2095001T5 (ja) |
GR (2) | GR3022090T3 (ja) |
NZ (1) | NZ245618A (ja) |
SG (1) | SG52402A1 (ja) |
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US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
US6083503A (en) * | 1991-08-28 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection |
CA2187345A1 (en) * | 1994-04-08 | 1995-10-19 | Howard L. Weiner | Treatment of autoimmune disease using oral tolerization and/or th2-enhancing cytokines |
US20030202980A1 (en) * | 1995-12-29 | 2003-10-30 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
US5980948A (en) * | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
WO1998007443A1 (fr) * | 1996-08-20 | 1998-02-26 | Freund Industrial Co., Ltd. | Microspheres contenant des immunogenes, procede de fabrication et procede permettant d'immuniser des animaux a l'aide de ces microspheres |
CN1228708A (zh) * | 1996-09-04 | 1999-09-15 | 有限会社多特 | 经口给药用含肽药物组合物 |
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US7879977B2 (en) | 1998-01-31 | 2011-02-01 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
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US8246945B2 (en) * | 2000-04-06 | 2012-08-21 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
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IL87710A (en) * | 1987-09-18 | 1992-06-21 | Ciba Geigy Ag | Covered floating retard form for controlled release in gastric juice |
US5236713A (en) * | 1987-10-21 | 1993-08-17 | Teikoku Seiyaku Kabushiki Kaisha | Preparation for intermittently releasing active agent applicable to oral cavity |
GB8826116D0 (en) * | 1988-11-08 | 1988-12-14 | Danbiosyst Ltd | Adhesive drug delivery composition |
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-
1993
- 1993-01-04 DK DK93300005T patent/DK0603992T4/da active
- 1993-01-04 DE DE1993605313 patent/DE69305313T3/de not_active Expired - Lifetime
- 1993-01-04 AT AT93300005T patent/ATE143803T1/de not_active IP Right Cessation
- 1993-01-04 ES ES93300005T patent/ES2095001T5/es not_active Expired - Lifetime
- 1993-01-04 CA CA 2086631 patent/CA2086631C/en not_active Expired - Lifetime
- 1993-01-04 SG SG1996004016A patent/SG52402A1/en unknown
- 1993-01-04 EP EP19930300005 patent/EP0603992B2/en not_active Expired - Lifetime
- 1993-01-05 AU AU31045/93A patent/AU664222B2/en not_active Ceased
- 1993-01-06 JP JP3107493A patent/JPH0710771A/ja active Pending
- 1993-01-06 NZ NZ245618A patent/NZ245618A/en not_active IP Right Cessation
-
1995
- 1995-01-20 US US08/405,604 patent/US5591433A/en not_active Expired - Lifetime
-
1996
- 1996-12-18 GR GR960403537T patent/GR3022090T3/el unknown
-
2001
- 2001-02-22 GR GR20010400286T patent/GR3035452T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE143803T1 (de) | 1996-10-15 |
GR3035452T3 (en) | 2001-05-31 |
ES2095001T5 (es) | 2001-03-16 |
EP0603992B1 (en) | 1996-10-09 |
AU3104593A (en) | 1994-07-07 |
EP0603992A1 (en) | 1994-06-29 |
ES2095001T3 (es) | 1997-02-01 |
DK0603992T3 (da) | 1997-03-24 |
SG52402A1 (en) | 1998-09-28 |
DE69305313T3 (de) | 2001-06-21 |
AU664222B2 (en) | 1995-11-09 |
DE69305313T2 (de) | 1997-02-20 |
JPH0710771A (ja) | 1995-01-13 |
US5591433A (en) | 1997-01-07 |
NZ245618A (en) | 1994-10-26 |
DE69305313D1 (de) | 1996-11-14 |
EP0603992B2 (en) | 2000-12-06 |
CA2086631A1 (en) | 1994-06-23 |
CA2086631C (en) | 1998-10-06 |
GR3022090T3 (en) | 1997-03-31 |
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