DE69305313T2 - Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen Proteinen - Google Patents
Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen ProteinenInfo
- Publication number
- DE69305313T2 DE69305313T2 DE69305313T DE69305313T DE69305313T2 DE 69305313 T2 DE69305313 T2 DE 69305313T2 DE 69305313 T DE69305313 T DE 69305313T DE 69305313 T DE69305313 T DE 69305313T DE 69305313 T2 DE69305313 T2 DE 69305313T2
- Authority
- DE
- Germany
- Prior art keywords
- protein
- therapeutic protein
- orally
- oral administration
- stabilizing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 230000001225 therapeutic effect Effects 0.000 title abstract 5
- 239000011248 coating agent Substances 0.000 abstract 2
- 238000000576 coating method Methods 0.000 abstract 2
- 239000003381 stabilizer Substances 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000004925 denaturation Methods 0.000 abstract 1
- 230000036425 denaturation Effects 0.000 abstract 1
- 238000005538 encapsulation Methods 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003094 microcapsule Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000813 small intestine Anatomy 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US99493292A | 1992-12-22 | 1992-12-22 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69305313D1 DE69305313D1 (de) | 1996-11-14 |
DE69305313T2 true DE69305313T2 (de) | 1997-02-20 |
DE69305313T3 DE69305313T3 (de) | 2001-06-21 |
Family
ID=25541237
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE1993605313 Expired - Lifetime DE69305313T3 (de) | 1992-12-22 | 1993-01-04 | Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen Proteinen |
Country Status (12)
Country | Link |
---|---|
US (1) | US5591433A (de) |
EP (1) | EP0603992B2 (de) |
JP (1) | JPH0710771A (de) |
AT (1) | ATE143803T1 (de) |
AU (1) | AU664222B2 (de) |
CA (1) | CA2086631C (de) |
DE (1) | DE69305313T3 (de) |
DK (1) | DK0603992T4 (de) |
ES (1) | ES2095001T5 (de) |
GR (2) | GR3022090T3 (de) |
NZ (1) | NZ245618A (de) |
SG (1) | SG52402A1 (de) |
Families Citing this family (69)
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ES2109362T3 (es) * | 1991-06-21 | 1998-01-16 | Univ Cincinnati | Unas proteinas administrables oralmente y metodo para hacerlas. |
US6613332B1 (en) | 1991-06-21 | 2003-09-02 | The University Of Cincinnati | Oral administration of therapeutic proteins |
US6083503A (en) * | 1991-08-28 | 2000-07-04 | The United States Of America As Represented By The Department Of Health And Human Services | Interleukin-2 stimulated T lymphocyte cell death for the treatment of autoimmune diseases, allergic responses, and graft rejection |
BR9507452A (pt) * | 1994-04-08 | 1997-08-05 | Brigham & Womens Hospital | Composição farmacêutica uso de um polipeptídeo não-interferon uso de uma quantidade de um antígeno padronizado e uma quantidade de um polipeptídeo não-interferon e produto contendo (1) uma quantidade de um antígeno padronizado e (11) uma quantidade de um polipeptídeo não-interferon |
US20030202980A1 (en) * | 1995-12-29 | 2003-10-30 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
US5980948A (en) * | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
WO1998007443A1 (fr) * | 1996-08-20 | 1998-02-26 | Freund Industrial Co., Ltd. | Microspheres contenant des immunogenes, procede de fabrication et procede permettant d'immuniser des animaux a l'aide de ces microspheres |
WO1998009645A1 (fr) * | 1996-09-04 | 1998-03-12 | Dott Research Laboratory | Compositions medicamenteuses contenant des peptides, destinees a l'administration orale |
US8828432B2 (en) | 1996-10-28 | 2014-09-09 | General Mills, Inc. | Embedding and encapsulation of sensitive components into a matrix to obtain discrete controlled release particles |
US20030158220A1 (en) * | 1997-11-03 | 2003-08-21 | Foss Joseph F. | Use of methylnaltrexone and related compounds to treat chronic opioid use side effects |
US6559158B1 (en) | 1997-11-03 | 2003-05-06 | Ur Labs, Inc. | Use of methylnaltrexone and related compounds to treat chronic opioid use side affects |
US6274591B1 (en) * | 1997-11-03 | 2001-08-14 | Joseph F. Foss | Use of methylnaltrexone and related compounds |
US7879977B2 (en) | 1998-01-31 | 2011-02-01 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
CA2319437C (en) * | 1998-01-31 | 2009-06-16 | University Of Arkansas | Methods and reagents for decreasing allergic reactions |
US6328967B1 (en) * | 1998-03-12 | 2001-12-11 | Allergenics, Inc. | Delivery system to modulate immune response |
US7201923B1 (en) | 1998-03-23 | 2007-04-10 | General Mills, Inc. | Encapsulation of sensitive liquid components into a matrix to obtain discrete shelf-stable particles |
PL193929B1 (pl) | 1998-03-23 | 2007-04-30 | Gen Mills Inc | Jadalny produkt na bazie skrobi, kompozycja odżywcza oraz sposób wytwarzania jadalnego produktu |
SE9801288D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
GB9818591D0 (en) * | 1998-08-27 | 1998-10-21 | Danbiosyst Uk | Pharmaceutical composition |
WO2000054797A2 (en) | 1999-03-17 | 2000-09-21 | Novartis Ag | Pharmaceutical compositions comprising tgf-beta |
US6500463B1 (en) | 1999-10-01 | 2002-12-31 | General Mills, Inc. | Encapsulation of sensitive components into a matrix to obtain discrete shelf-stable particles |
US20010026800A1 (en) * | 2000-01-07 | 2001-10-04 | Michael Jacob G. | Selective activation of a TH1 or TH2 lymphocyte regulated immune response |
US20050063994A1 (en) * | 2000-04-06 | 2005-03-24 | Caplan Michael J. | Methods and reagents for decreasing clinical reaction to allergy |
AU1951001A (en) * | 2000-04-06 | 2001-09-17 | Panacea Pharm Llc | Microbial delivery system |
US8246945B2 (en) * | 2000-04-06 | 2012-08-21 | University Of Arkansas | Methods and reagents for decreasing clinical reaction to allergy |
US6468568B1 (en) | 2000-06-16 | 2002-10-22 | General Mills, Inc. | Oligosaccharide encapsulated mineral and vitamin ingredients |
US6436453B1 (en) | 2000-06-16 | 2002-08-20 | General Mills, Inc. | Production of oil encapsulated minerals and vitamins in a glassy matrix |
US6558718B1 (en) | 2000-06-19 | 2003-05-06 | General Mills, Inc. | Nutrient clusters for food products and methods of preparation |
CN1268641C (zh) | 2000-11-10 | 2006-08-09 | 普罗蒂奥制药公司 | 载脂蛋白类似物 |
WO2002098422A1 (en) * | 2001-06-05 | 2002-12-12 | University Of Chicago | Use of methylnaltrexone to treat immune suppression |
KR20040047915A (ko) * | 2001-10-15 | 2004-06-05 | 룀 게엠베하 운트 콤파니 카게 | 활성제로서 펩타이드 또는 단백질을 함유하는 생약 형태를제조하기 위한 공중합체의 용도 |
KR100469943B1 (ko) * | 2002-03-20 | 2005-02-02 | 삼성정밀화학 주식회사 | 장용성 코팅제로 사용되는 아크릴 공중합체의 제조 방법 |
US20040043070A1 (en) * | 2002-05-14 | 2004-03-04 | Ayres James W. | Hot melt coating by direct blending and coated substrates |
US7431986B2 (en) | 2002-07-24 | 2008-10-07 | General Mills, Inc. | Encapsulation of sensitive components using pre-emulsification |
CA2521369A1 (en) * | 2003-04-08 | 2004-10-28 | Progenics Pharmaceuticals, Inc. | The use of peripheral opiois antagonists, especially methylnaltrexone to treat irritable bowel syndrome |
EP1638607A1 (de) * | 2003-04-08 | 2006-03-29 | Progenics Pharmaceuticals, Inc. | Kombinationstherapie gegen obstipation mit einem laxativ und einem peripheren opioid-antagonisten |
PL2368553T3 (pl) * | 2003-04-08 | 2015-05-29 | Progenics Pharm Inc | Preparaty farmaceutyczne zawierające metylonaltrekson |
US20070141071A1 (en) * | 2003-05-14 | 2007-06-21 | Oregon State University | Hot melt coating by direct blending and coated substrates |
US20060029590A1 (en) * | 2004-06-10 | 2006-02-09 | Christopher Thanos | Administration of neutral endopeptidase to treat inflammatory bowel disease |
JP2008502605A (ja) * | 2004-06-16 | 2008-01-31 | スマート ドラッグ システムズ インコーポレイティド | 徐放性ワクチン組成物 |
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MX2007010833A (es) * | 2005-03-07 | 2009-02-17 | Univ Chicago | Uso de antagonistas opioides para atenuar proliferacion y migracion de células endoteliales. |
US8518962B2 (en) | 2005-03-07 | 2013-08-27 | The University Of Chicago | Use of opioid antagonists |
US8524731B2 (en) | 2005-03-07 | 2013-09-03 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
US9662325B2 (en) | 2005-03-07 | 2017-05-30 | The University Of Chicago | Use of opioid antagonists to attenuate endothelial cell proliferation and migration |
AR057035A1 (es) * | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
AR057325A1 (es) * | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
US20080194611A1 (en) * | 2005-06-03 | 2008-08-14 | Alverdy John C | Modulation of Cell Barrier Dysfunction |
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US7803413B2 (en) | 2005-10-31 | 2010-09-28 | General Mills Ip Holdings Ii, Llc. | Encapsulation of readily oxidizable components |
WO2007112747A1 (en) * | 2006-03-31 | 2007-10-11 | Curalogic A/S | Immunogen combinations |
TW200817048A (en) * | 2006-09-08 | 2008-04-16 | Wyeth Corp | Dry powder compound formulations and uses thereof |
JP2010522756A (ja) | 2007-03-29 | 2010-07-08 | プロジェニックス ファーマシューティカルズ,インコーポレーテッド | 結晶形およびその使用 |
AU2008233129B2 (en) * | 2007-03-29 | 2014-03-20 | Progenics Pharmaceuticals, Inc. | Peripheral opioid receptor antagonists and uses thereof |
ES2540551T3 (es) * | 2007-03-29 | 2015-07-10 | Wyeth Llc | Antagonistas de receptores opioides periféricos y usos de los mismos |
CN101959892B (zh) * | 2008-02-06 | 2014-01-08 | 普罗热尼奇制药公司 | (r),(r)-2,2’-二-甲基纳曲酮的制备和用途 |
JP5647098B2 (ja) | 2008-03-21 | 2014-12-24 | ザ ユニヴァーシティー オヴ シカゴ | オピオイド拮抗薬とmTOR阻害薬を用いた治療 |
US8703152B2 (en) | 2008-06-03 | 2014-04-22 | University Of Rochester | Methods of treating inflammatory intestinal disease and managing symptoms thereof |
WO2010002576A1 (en) | 2008-07-01 | 2010-01-07 | University Of Chicago | Particles containing an opioid receptor antagonist and methods of use |
JP2010077057A (ja) * | 2008-09-25 | 2010-04-08 | Kagoshima Univ | 抗食物アレルギーワクチン |
CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
JP5931449B2 (ja) * | 2012-01-11 | 2016-06-08 | 日東電工株式会社 | 医薬組成物及びその製造方法 |
US10940170B2 (en) | 2014-07-07 | 2021-03-09 | University Of Massachusetts | Anthelmintic probiotic compositions and methods |
EP3718404A1 (de) | 2014-10-17 | 2020-10-07 | Salix Pharmaceuticals, Inc. | Verwendung von methylnaltrexon zur verringerung der tumorprogression |
US11484568B2 (en) | 2016-01-15 | 2022-11-01 | University Of Massachusetts | Anthelmintic compositions and methods |
US11844815B2 (en) | 2017-05-23 | 2023-12-19 | University Of Massachusetts | Purified anthelmintic compositions and related methods |
WO2020106757A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
WO2020257017A1 (en) | 2019-06-18 | 2020-12-24 | Progenity, Inc. | Ingestible device with component capable of residing in the gastrointestinal tract |
US11707610B2 (en) | 2019-12-13 | 2023-07-25 | Biora Therapeutics, Inc. | Ingestible device for delivery of therapeutic agent to the gastrointestinal tract |
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-
1993
- 1993-01-04 ES ES93300005T patent/ES2095001T5/es not_active Expired - Lifetime
- 1993-01-04 AT AT93300005T patent/ATE143803T1/de not_active IP Right Cessation
- 1993-01-04 DK DK93300005T patent/DK0603992T4/da active
- 1993-01-04 DE DE1993605313 patent/DE69305313T3/de not_active Expired - Lifetime
- 1993-01-04 SG SG1996004016A patent/SG52402A1/en unknown
- 1993-01-04 CA CA 2086631 patent/CA2086631C/en not_active Expired - Lifetime
- 1993-01-04 EP EP19930300005 patent/EP0603992B2/de not_active Expired - Lifetime
- 1993-01-05 AU AU31045/93A patent/AU664222B2/en not_active Ceased
- 1993-01-06 JP JP3107493A patent/JPH0710771A/ja active Pending
- 1993-01-06 NZ NZ245618A patent/NZ245618A/en not_active IP Right Cessation
-
1995
- 1995-01-20 US US08/405,604 patent/US5591433A/en not_active Expired - Lifetime
-
1996
- 1996-12-18 GR GR960403537T patent/GR3022090T3/el unknown
-
2001
- 2001-02-22 GR GR20010400286T patent/GR3035452T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US5591433A (en) | 1997-01-07 |
DK0603992T3 (da) | 1997-03-24 |
NZ245618A (en) | 1994-10-26 |
GR3035452T3 (en) | 2001-05-31 |
AU3104593A (en) | 1994-07-07 |
ATE143803T1 (de) | 1996-10-15 |
EP0603992B2 (de) | 2000-12-06 |
EP0603992B1 (de) | 1996-10-09 |
CA2086631A1 (en) | 1994-06-23 |
ES2095001T3 (es) | 1997-02-01 |
AU664222B2 (en) | 1995-11-09 |
SG52402A1 (en) | 1998-09-28 |
JPH0710771A (ja) | 1995-01-13 |
EP0603992A1 (de) | 1994-06-29 |
CA2086631C (en) | 1998-10-06 |
ES2095001T5 (es) | 2001-03-16 |
DE69305313D1 (de) | 1996-11-14 |
GR3022090T3 (en) | 1997-03-31 |
DE69305313T3 (de) | 2001-06-21 |
DK0603992T4 (da) | 2001-03-05 |
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