DK0576612T3 - Polyoxypropylen/polyoxyethylen-copolymerer med forbedret aktivitet - Google Patents
Polyoxypropylen/polyoxyethylen-copolymerer med forbedret aktivitetInfo
- Publication number
- DK0576612T3 DK0576612T3 DK92910791T DK92910791T DK0576612T3 DK 0576612 T3 DK0576612 T3 DK 0576612T3 DK 92910791 T DK92910791 T DK 92910791T DK 92910791 T DK92910791 T DK 92910791T DK 0576612 T3 DK0576612 T3 DK 0576612T3
- Authority
- DK
- Denmark
- Prior art keywords
- polyoxypropylene
- polyoxyethylene copolymers
- preparations
- copolymers
- improved activity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/77—Polymers containing oxygen of oxiranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/04—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers only
- C08G65/06—Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G65/08—Saturated oxiranes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
- C08G65/2606—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups
- C08G65/2609—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen containing hydroxyl groups containing aliphatic hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2618—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen
- C08G65/2621—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups
- C08G65/2624—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing nitrogen containing amine groups containing aliphatic amine groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67328991A | 1991-03-19 | 1991-03-19 | |
US84787492A | 1992-03-13 | 1992-03-13 | |
PCT/US1992/002254 WO1992016484A1 (en) | 1991-03-19 | 1992-03-18 | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0576612T3 true DK0576612T3 (da) | 2000-05-22 |
Family
ID=27100911
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92910791T DK0576612T3 (da) | 1991-03-19 | 1992-03-18 | Polyoxypropylen/polyoxyethylen-copolymerer med forbedret aktivitet |
Country Status (19)
Country | Link |
---|---|
US (7) | US5523492A (da) |
EP (1) | EP0576612B1 (da) |
JP (1) | JP2647556B2 (da) |
KR (1) | KR100224539B1 (da) |
CN (1) | CN1069741A (da) |
AT (1) | ATE187154T1 (da) |
AU (1) | AU662146B2 (da) |
CA (1) | CA2106474C (da) |
CZ (1) | CZ194693A3 (da) |
DE (1) | DE69230372T2 (da) |
DK (1) | DK0576612T3 (da) |
ES (1) | ES2140408T3 (da) |
GR (1) | GR3032726T3 (da) |
HU (1) | HUT67762A (da) |
IE (1) | IE920860A1 (da) |
IL (1) | IL101305A (da) |
NO (1) | NO307890B1 (da) |
SK (1) | SK100893A3 (da) |
WO (1) | WO1992016484A1 (da) |
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-
1992
- 1992-03-18 EP EP92910791A patent/EP0576612B1/en not_active Expired - Lifetime
- 1992-03-18 DE DE69230372T patent/DE69230372T2/de not_active Expired - Fee Related
- 1992-03-18 AU AU17730/92A patent/AU662146B2/en not_active Ceased
- 1992-03-18 CZ CS931946A patent/CZ194693A3/cs unknown
- 1992-03-18 IE IE086092A patent/IE920860A1/en not_active IP Right Cessation
- 1992-03-18 WO PCT/US1992/002254 patent/WO1992016484A1/en active IP Right Grant
- 1992-03-18 AT AT92910791T patent/ATE187154T1/de not_active IP Right Cessation
- 1992-03-18 CN CN92102964A patent/CN1069741A/zh active Pending
- 1992-03-18 CA CA002106474A patent/CA2106474C/en not_active Expired - Fee Related
- 1992-03-18 KR KR1019930702810A patent/KR100224539B1/ko not_active IP Right Cessation
- 1992-03-18 JP JP4509970A patent/JP2647556B2/ja not_active Expired - Fee Related
- 1992-03-18 HU HU9302628A patent/HUT67762A/hu unknown
- 1992-03-18 DK DK92910791T patent/DK0576612T3/da active
- 1992-03-18 ES ES92910791T patent/ES2140408T3/es not_active Expired - Lifetime
- 1992-03-18 SK SK1008-93A patent/SK100893A3/sk unknown
- 1992-03-19 IL IL10130592A patent/IL101305A/en not_active IP Right Cessation
-
1993
- 1993-07-02 US US08/087,136 patent/US5523492A/en not_active Ceased
- 1993-09-17 NO NO933337A patent/NO307890B1/no unknown
-
1996
- 1996-06-03 US US08/657,161 patent/US5691387A/en not_active Ceased
-
1997
- 1997-07-08 US US08/889,342 patent/US5990241A/en not_active Expired - Fee Related
-
1998
- 1998-06-02 US US09/089,043 patent/USRE36665E/en not_active Expired - Lifetime
-
1999
- 1999-08-05 US US09/368,855 patent/US6359014B1/en not_active Expired - Fee Related
- 1999-11-19 US US09/444,417 patent/USRE37285E1/en not_active Expired - Fee Related
-
2000
- 2000-02-23 GR GR20000400425T patent/GR3032726T3/el not_active IP Right Cessation
-
2001
- 2001-12-14 US US10/017,223 patent/US6747064B2/en not_active Expired - Fee Related
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