DK0559116T3 - Mikrobiologisk fremgangsmåde til hydroxylering af nitrogenholdige heterocycliske carboxylsyrer - Google Patents

Mikrobiologisk fremgangsmåde til hydroxylering af nitrogenholdige heterocycliske carboxylsyrer

Info

Publication number
DK0559116T3
DK0559116T3 DK93103221.3T DK93103221T DK0559116T3 DK 0559116 T3 DK0559116 T3 DK 0559116T3 DK 93103221 T DK93103221 T DK 93103221T DK 0559116 T3 DK0559116 T3 DK 0559116T3
Authority
DK
Denmark
Prior art keywords
nitrogen
carboxylic acids
hydroxylation
containing heterocyclic
heterocyclic carboxylic
Prior art date
Application number
DK93103221.3T
Other languages
English (en)
Inventor
Andreas Dr Kiener
Klaus Heinzmann
Andreas Dr Tschech
Andreas Tinschert
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Application granted granted Critical
Publication of DK0559116T3 publication Critical patent/DK0559116T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10Nitrogen as only ring hetero atom
    • C12P17/12Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK93103221.3T 1992-03-04 1993-03-01 Mikrobiologisk fremgangsmåde til hydroxylering af nitrogenholdige heterocycliske carboxylsyrer DK0559116T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH67292 1992-03-04

Publications (1)

Publication Number Publication Date
DK0559116T3 true DK0559116T3 (da) 1997-06-16

Family

ID=4192473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93103221.3T DK0559116T3 (da) 1992-03-04 1993-03-01 Mikrobiologisk fremgangsmåde til hydroxylering af nitrogenholdige heterocycliske carboxylsyrer

Country Status (17)

Country Link
US (2) US5306630A (da)
EP (1) EP0559116B1 (da)
JP (1) JPH06199797A (da)
KR (1) KR100274205B1 (da)
CN (1) CN1077748A (da)
AT (1) ATE153698T1 (da)
CA (1) CA2091005C (da)
CZ (1) CZ282939B6 (da)
DE (1) DE59306547D1 (da)
DK (1) DK0559116T3 (da)
ES (1) ES2101887T3 (da)
GE (1) GEP19991710B (da)
GR (1) GR3024286T3 (da)
LT (1) LT3114B (da)
LV (1) LV10504B (da)
RU (1) RU2122029C1 (da)
SK (1) SK279322B6 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9426293D0 (en) * 1994-12-28 1995-02-22 Zeneca Ltd Composition,compound and use
US5763232A (en) * 1996-02-15 1998-06-09 Mitsubishi Chemical Corporation Method for producing 3-hydroxy nitrogen-containing six-membered cylic compound
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
ATE384120T1 (de) * 1999-08-27 2008-02-15 Invitrogen Corp Metallbindende verbindungen und deren verwendung in zusammensetzungen für zellkulturmedien
AU2002220603A1 (en) * 2000-10-06 2002-04-15 Lonza A.G. Biotechnological method for preparing carboxylic acids with a hydroxy-nitrogen heterocycle
CA2700490C (en) * 2007-09-27 2015-10-27 Toyama Chemical Co. Ltd. Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and method for producing the same
KR101902857B1 (ko) * 2010-11-12 2018-10-01 후지필름 가부시키가이샤 피라지노〔2,3-d〕이소옥사졸 유도체

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081451A (en) * 1975-03-20 1978-03-28 Schering Corporation Process for preparing 2-halogeno nicotinic acids
JPS6061567A (ja) * 1983-09-14 1985-04-09 ロンザ リミテツド 2−ピリジンカルボン酸−ν−オキサイドから2−ヒドロキシピリジンを製造する方法
CH658866A5 (de) * 1984-02-21 1986-12-15 Lonza Ag Verfahren zur herstellung von 6-hydroxynikotinsaeure.
CH658867A5 (de) * 1984-02-22 1986-12-15 Lonza Ag Verfahren zur herstellung von 6-hydroxynikotinsaeure.
IN170700B (da) * 1989-12-20 1992-05-02 Lonza Ag
US5236832A (en) * 1990-02-13 1993-08-17 Lonza, Ltd. Microbiological oxidation of methyl groups in heterocycles
US5242816A (en) * 1990-07-10 1993-09-07 Lonza Ltd. Microbiological oxidation of alkyl groups in heterocycles
CZ279464B6 (cs) * 1990-09-24 1995-05-17 Lonza A.G. Způsob hydroxylace methylových skupin v aromatických heterocyklech, hybridní plasmidy pL05 a p L04 uložené v mikroorganismech Pseudomonas putida a Escherichia coli
SK278514B6 (en) * 1990-09-25 1997-08-06 Andreas Kiener Rhodococcus erythropolis microorganism and a method for producing hydroxylated pyrazines and quinoxalines
KR100233330B1 (ko) * 1991-02-04 1999-12-01 하인즈 모제르 6-히드록시피콜린산을 제조하기 위한 미생물학적 방법
US5238830A (en) * 1991-02-04 1993-08-24 Lonza Ltd. Microbiological process for the production of 6-hydroxypicolinic acid
JPH0728750B2 (ja) * 1991-03-30 1995-04-05 池田食研株式会社 微生物によるピラジン酸の水酸化物の製造方法
JPH0740951B2 (ja) * 1991-03-30 1995-05-10 池田食研株式会社 微生物による含窒素複素環化合物の水酸化物の製造方法
FI922125A (fi) * 1991-06-21 1992-12-22 Lonza Ag Mikrobidogiskt foerfarande foer framstaellning av 5-hydroxipyrazinkarboxylsyra
MX9204902A (es) * 1991-08-30 1993-05-01 Lonza Ag Procedimiento microbiologico para la preparacion de acido 6-hidroxipirazincarboxilico.
JP2583719B2 (ja) * 1992-08-10 1997-02-19 株式会社日立製作所 ガス制御式出力安定化ガスレーザ装置

Also Published As

Publication number Publication date
DE59306547D1 (de) 1997-07-03
CZ282939B6 (cs) 1997-11-12
SK279322B6 (sk) 1998-10-07
LT3114B (en) 1994-12-27
ATE153698T1 (de) 1997-06-15
CN1077748A (zh) 1993-10-27
US5306630A (en) 1994-04-26
JPH06199797A (ja) 1994-07-19
RU2122029C1 (ru) 1998-11-20
LV10504B (en) 1996-02-20
KR100274205B1 (ko) 2000-12-15
CA2091005A1 (en) 1993-09-05
EP0559116A3 (en) 1994-07-06
LTIP377A (en) 1994-06-15
ES2101887T3 (es) 1997-07-16
CZ27293A3 (en) 1994-01-19
EP0559116A2 (de) 1993-09-08
LV10504A (lv) 1995-02-20
SK13793A3 (en) 1993-10-06
CA2091005C (en) 2001-09-25
EP0559116B1 (de) 1997-05-28
KR930019834A (ko) 1993-10-19
GEP19991710B (en) 1999-08-05
US5364940A (en) 1994-11-15
GR3024286T3 (en) 1997-10-31

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