LTIP377A - Microbiological method for hydroxilation of carbonic acids of nitrogen containing heterocycles - Google Patents

Microbiological method for hydroxilation of carbonic acids of nitrogen containing heterocycles

Info

Publication number
LTIP377A
LTIP377A LTIP377A LTIP377A LTIP377A LT IP377 A LTIP377 A LT IP377A LT IP377 A LTIP377 A LT IP377A LT IP377 A LTIP377 A LT IP377A LT IP377 A LTIP377 A LT IP377A
Authority
LT
Lithuania
Prior art keywords
hydroxilation
nitrogen containing
containing heterocycles
nitrogen
carbonic acids
Prior art date
Application number
LTIP377A
Inventor
Andreas Kiener
Andreas Tschech
Andreas Tinschert
Klaus Heinzmann
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of LTIP377A publication Critical patent/LTIP377A/en
Publication of LT3114B publication Critical patent/LT3114B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C12P17/12—Nitrogen as only ring hetero atom containing a six-membered hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A new microbiological process for the production of hydroxy-nitrogen-heterocyclic-carboxylic acids or their soluble salts of the general formula: (* CHEMICAL STRUCTURE *) I wherein R1 and R2 are the same or different and each is a hydrogen atom, a halogen atom or a C1-C4 alkyl group and X is a nitrogen atom or a CR3 function, wherein R3 is a hydrogen atom or a halogen atom, starting from the corresponding nitrogen-heterocyclic-carboxylic acids, as well as new microorganisms suitable for use in the process.
LTIP377A 1992-03-04 1993-03-03 Microbiological method for hydroxilation of carbonic acids of nitrogen containing heterocycles LT3114B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH67292 1992-03-04

Publications (2)

Publication Number Publication Date
LTIP377A true LTIP377A (en) 1994-06-15
LT3114B LT3114B (en) 1994-12-27

Family

ID=4192473

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP377A LT3114B (en) 1992-03-04 1993-03-03 Microbiological method for hydroxilation of carbonic acids of nitrogen containing heterocycles

Country Status (17)

Country Link
US (2) US5306630A (en)
EP (1) EP0559116B1 (en)
JP (1) JPH06199797A (en)
KR (1) KR100274205B1 (en)
CN (1) CN1077748A (en)
AT (1) ATE153698T1 (en)
CA (1) CA2091005C (en)
CZ (1) CZ282939B6 (en)
DE (1) DE59306547D1 (en)
DK (1) DK0559116T3 (en)
ES (1) ES2101887T3 (en)
GE (1) GEP19991710B (en)
GR (1) GR3024286T3 (en)
LT (1) LT3114B (en)
LV (1) LV10504B (en)
RU (1) RU2122029C1 (en)
SK (1) SK279322B6 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9426293D0 (en) * 1994-12-28 1995-02-22 Zeneca Ltd Composition,compound and use
US5763232A (en) * 1996-02-15 1998-06-09 Mitsubishi Chemical Corporation Method for producing 3-hydroxy nitrogen-containing six-membered cylic compound
US6767741B1 (en) * 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
JP4972261B2 (en) * 1999-08-27 2012-07-11 ライフ テクノロジーズ コーポレーション Metal binding compounds and their use in cell culture media compositions
WO2002029021A2 (en) * 2000-10-06 2002-04-11 Lonza Ag Biotechnological method for preparing carboxylic acids with a hydroxy-nitrogen heterocycle
DK2192117T3 (en) * 2007-09-27 2014-06-30 Toyama Chemical Co Ltd Organic amine salt of 6-fluoro-3-hydroxy-2-pyrazinecarbonitrile and process for its preparation
CN103347884B (en) * 2010-11-12 2015-12-02 富士胶片株式会社 Pyrazine is [2,3-d] different * oxazole derivatives also
KR102848894B1 (en) * 2022-10-26 2025-08-21 한국원자력연구원 Method of Distinguishing Synthetic Nicontine From Natual Nicotine

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4081451A (en) * 1975-03-20 1978-03-28 Schering Corporation Process for preparing 2-halogeno nicotinic acids
JPS6061567A (en) * 1983-09-14 1985-04-09 ロンザ　リミテツド Manufacture of 2-hydroxypyridine from 2-pyridinecarboxylic acid-n-oxide
CH658866A5 (en) * 1984-02-21 1986-12-15 Lonza Ag METHOD FOR PRODUCING 6-HYDROXYNICOTINIC ACID.
CH658867A5 (en) * 1984-02-22 1986-12-15 Lonza Ag METHOD FOR PRODUCING 6-HYDROXYNICOTINIC ACID.
IN170700B (en) * 1989-12-20 1992-05-02 Lonza Ag
US5236832A (en) * 1990-02-13 1993-08-17 Lonza, Ltd. Microbiological oxidation of methyl groups in heterocycles
US5242816A (en) * 1990-07-10 1993-09-07 Lonza Ltd. Microbiological oxidation of alkyl groups in heterocycles
CZ279464B6 (en) * 1990-09-24 1995-05-17 Lonza A.G. HYDROXYLATION PROCESS OF METHYL GROUPS IN AROMATIC HETERO CYCLES, HYBRID PLASMIDS pLO5 AND pLO4 AND MICRO-ORGANISMS PSEUDOMONA PUTIDA AND ESCHERICHIA COLI
CZ279488B6 (en) * 1990-09-25 1995-05-17 Lonza A.G. Micro-organisms rhodococcus erythropolis and arthrobacter sp. as well as micro-biological preparation of hydroxylated pyrazines and quinoxalines.
US5238830A (en) * 1991-02-04 1993-08-24 Lonza Ltd. Microbiological process for the production of 6-hydroxypicolinic acid
KR100233330B1 (en) * 1991-02-04 1999-12-01 하인즈 모제르 Microbiological Methods for Preparing 6-hydroxypicolinic Acid
JPH0728750B2 (en) * 1991-03-30 1995-04-05 池田食研株式会社 Method for producing hydroxide of pyrazinic acid by microorganism
JPH0740951B2 (en) * 1991-03-30 1995-05-10 池田食研株式会社 Method for producing hydroxide of nitrogen-containing heterocyclic compound by microorganism
FI922125A7 (en) * 1991-06-21 1992-12-22 Lonza Ag Microbiological process for the preparation of 5-hydroxypyrazinecarboxylic acid
MX9204902A (en) * 1991-08-30 1993-05-01 Lonza Ag MICROBIOLOGICAL PROCEDURE FOR THE PREPARATION OF 6-HYDROXIPIRAZINCARBOXILIC ACID.

Also Published As

Publication number Publication date
ES2101887T3 (en) 1997-07-16
EP0559116A2 (en) 1993-09-08
DE59306547D1 (en) 1997-07-03
US5306630A (en) 1994-04-26
EP0559116A3 (en) 1994-07-06
EP0559116B1 (en) 1997-05-28
CN1077748A (en) 1993-10-27
ATE153698T1 (en) 1997-06-15
LV10504A (en) 1995-02-20
CA2091005C (en) 2001-09-25
CA2091005A1 (en) 1993-09-05
CZ27293A3 (en) 1994-01-19
SK279322B6 (en) 1998-10-07
LT3114B (en) 1994-12-27
KR100274205B1 (en) 2000-12-15
CZ282939B6 (en) 1997-11-12
LV10504B (en) 1996-02-20
US5364940A (en) 1994-11-15
GR3024286T3 (en) 1997-10-31
GEP19991710B (en) 1999-08-05
RU2122029C1 (en) 1998-11-20
SK13793A3 (en) 1993-10-06
KR930019834A (en) 1993-10-19
JPH06199797A (en) 1994-07-19
DK0559116T3 (en) 1997-06-16

Similar Documents

Publication Publication Date Title
IL129724A0 (en) Crystals of benzimidazole derivatives and their production
HU9200384D0 (en) Pharmaceutical heterocyclic compounds
HUP0100394A2 (en) Imidazo-triazinone derivatives bearing a phenyl substituent in Position 2, their production process and pharmaceutical preparations containing them
UA48991C2 (en) Derivatives of phenylacetic acid, method of their preparation (variants), intermediate producrs used for their preparation and pest control
EP0192060B1 (en) Heterocyclic compounds
EP0320118A3 (en) Peptides with collagenase inhibiting activity
AU589427B2 (en) Pyridonecarboxylic acid derivatives and process for their preparation
MX9800412A (en) Process for producing n-substituted 3-hydroxypyrazoles.
ES8301915A1 (en) 2-Oxoazetidine derivatives, their production and use.
GB1377506A (en) Aminopyridine derivatives
LTIP377A (en) Microbiological method for hydroxilation of carbonic acids of nitrogen containing heterocycles
MY132057A (en) Quinoxalinones, a process for their preparation and their use
TW238304B (en) A process for the preparation of 1-substituted-5(4H)-tetrazolinones
MX9801133A (en) Didepsipeptide-based endoparasiticides, new didepsipeptides and process for preparing the same.
MX9702089A (en) Bicyclic carboxamides as 5-ht1a antagonists.
ATE195115T1 (en) METHOD FOR PRODUCING 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALINE DERIVATIVES
EP0367671A3 (en) Novel beta-d-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
TW358087B (en) Method for preparing carbamoylmethylurea derivatives
MX9710530A (en) BENZO[g]QUINOLINE DERIVATIVES.

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 20030303