DK0547422T3 - Stabile pulverformige vitamin- og/eller carotenoid-præparater og fremgangsmåde til deres fremstilling - Google Patents

Stabile pulverformige vitamin- og/eller carotenoid-præparater og fremgangsmåde til deres fremstilling

Info

Publication number
DK0547422T3
DK0547422T3 DK92120456.6T DK92120456T DK0547422T3 DK 0547422 T3 DK0547422 T3 DK 0547422T3 DK 92120456 T DK92120456 T DK 92120456T DK 0547422 T3 DK0547422 T3 DK 0547422T3
Authority
DK
Denmark
Prior art keywords
preparation
methods
carotenoid preparations
stable powdery
powdery vitamin
Prior art date
Application number
DK92120456.6T
Other languages
English (en)
Inventor
Joachim U Dr Schneider
Udo Dr Rheude
Wolfgang Dr Bewert
Horst Dr Schumacher
Guenter Dr Gaus
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0547422T3 publication Critical patent/DK0547422T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
    • A61K9/1623Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1658Proteins, e.g. albumin, gelatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
DK92120456.6T 1991-12-14 1992-12-01 Stabile pulverformige vitamin- og/eller carotenoid-præparater og fremgangsmåde til deres fremstilling DK0547422T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4141351A DE4141351A1 (de) 1991-12-14 1991-12-14 Stabile pulverfoermige vitamin- und/oder carotinoid-praeparate und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
DK0547422T3 true DK0547422T3 (da) 1996-04-01

Family

ID=6447112

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92120456.6T DK0547422T3 (da) 1991-12-14 1992-12-01 Stabile pulverformige vitamin- og/eller carotenoid-præparater og fremgangsmåde til deres fremstilling

Country Status (7)

Country Link
US (1) US5356636A (da)
EP (1) EP0547422B1 (da)
JP (1) JP2519008B2 (da)
CA (1) CA2083754C (da)
DE (2) DE4141351A1 (da)
DK (1) DK0547422T3 (da)
IL (1) IL103866A (da)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110139A0 (en) * 1993-06-28 1994-10-07 Howard Foundation Pharmaceutically-active antioxidants
CN1067548C (zh) * 1994-01-21 2001-06-27 上海第六制药厂 β-胡萝卜素或类胡萝卜素微型胶囊的制备及其应用
DE4405545A1 (de) * 1994-02-22 1995-08-31 Dietl Hans Fettlösliche Vitamine enthaltende Zubereitung zur oralen Applikation
DE19539574A1 (de) 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
JPH09124470A (ja) 1995-10-26 1997-05-13 Suntory Ltd 抗ストレス組成物
US5854015A (en) * 1995-10-31 1998-12-29 Applied Food Biotechnology, Inc. Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion
US5747544A (en) * 1995-10-31 1998-05-05 Applied Food Biotechnology, Inc. Method of using pure 3R-3'R stereoisomer of zeaxanthin to treat or prevent retinal degeneration in humans
US5827652A (en) * 1995-10-31 1998-10-27 Applied Food Biotechnology, Inc. Zeaxanthin formulations for human ingestion
CA2188983C (en) 1995-10-31 2001-02-27 Kevin M. Garnett Pure 3r-3'r stereoisomer of zeaxanthin for treating macular degeneration in humans
US5948443A (en) * 1996-02-23 1999-09-07 Medical Doctor's Research Institute, Inc. Acetylsalicylic acid and micronutrient supplementation for nutritional losses and coronary heart disease
JP3555640B2 (ja) * 1996-05-10 2004-08-18 ライオン株式会社 天然カロチノイドを包含した多芯型構造のマイクロカプセル並びに錠剤、食品用及び医薬品用配合剤
GB9616910D0 (en) * 1996-08-12 1996-09-25 Dunnett Mark A method of increasing ›-alanylihistidine pipetide synthesis and accumulation in humans and animals
DE19637517A1 (de) * 1996-09-13 1998-03-19 Basf Ag Herstellung von pulverförmigen, kaltwasserdispergierbaren Carotinoid-Zubereitungen und die Verwendung der neuen Carotinoid-Zubereitungen
DE19642359A1 (de) * 1996-10-14 1998-04-16 Basf Ag Stabile Emulsionen und Trockenpulver von Mischungen fettlöslicher Vitamine, deren Herstellung und Verwendung
DE19649062A1 (de) * 1996-11-27 1998-05-28 Basf Ag Flüssige, mit Öl mischbare Carotinoid-Zubereitungen
US20030203036A1 (en) * 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
DE19703469C2 (de) * 1997-01-31 2003-10-30 Wolfgang Von Rhein Verfahren zur Herstellung eines oxidationsgeschützten Vitamin-C-Präparats
US5976568A (en) * 1997-02-21 1999-11-02 Medical Doctors' Research Institute, Inc. Modular system of dietary supplement compositions for optimizing health benefits and methods
US6007856A (en) * 1997-08-08 1999-12-28 The Procter & Gamble Company Oil-in-water dispersions of β-carotene and other carotenoids stable against oxidation prepared from water-dispersible beadlets having high concentrations of carotenoid
DE69830333T2 (de) * 1997-10-20 2006-01-26 Dainippon Pharmaceutical Co., Ltd. SCHNELLÖSLICHE ARZNEIMITTELZUSAMMENSETZUNG ENTHALTEND MIKRONISiERTE AS-3201
EP0913177A1 (de) 1997-11-03 1999-05-06 Roche Diagnostics GmbH Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung
JP4027535B2 (ja) * 1998-05-26 2007-12-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 脂溶性薬物を含有した粉末
WO2000018254A2 (en) * 1998-09-25 2000-04-06 Kemin Industries, Inc. Method of protecting heat- or oxygen-labile compounds to preserve activity and bioavailability
US6146671A (en) * 1999-05-08 2000-11-14 Kemin Industries, Inc. Method and protecting heat-or oxygen-labile compounds to preserve activity and bioavailability
ATE277527T1 (de) * 1999-07-06 2004-10-15 Dsm Ip Assets Bv Zusammensetzung, die fettlösliche substanzen in einer kohlenhydratmatrix enthält
US6582721B1 (en) 1999-09-17 2003-06-24 Alcon, Inc. Stable carotene-xanthophyll beadlet compositions and methods of use
US6328995B1 (en) * 1999-09-24 2001-12-11 Basf Aktiengesellschaft Stable vitamin and/or carotenoid products in powder form and process for their production
US6511675B2 (en) 2000-06-12 2003-01-28 Access Business Group International, Llc Composition and method for correcting a dietary phytochemical deficiency
US7438936B2 (en) * 2000-06-12 2008-10-21 Access Business Group International Llc Dietary supplement and related method
US6989161B2 (en) 2000-06-12 2006-01-24 Access Business Group International Llc Phytonutrient nutritional supplement
US7939115B2 (en) * 2000-06-12 2011-05-10 Access Business Group International Llc Dietary supplement and related method
US7416749B2 (en) * 2000-06-12 2008-08-26 Access Business Group International Llc Dietary supplement and related method
US7575761B2 (en) 2000-06-30 2009-08-18 Novartis Pharma Ag Spray drying process control of drying kinetics
US7691406B2 (en) * 2000-10-27 2010-04-06 ZeaVision LLC. Zeaxanthin formulations for human ingestion
DE10064387A1 (de) * 2000-12-21 2002-06-27 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Sauerstoff-haltiger Carotinoide
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
CA2450931C (en) * 2001-08-23 2009-10-13 Bruno Leuenberger Novel stabilized carotenoid compositions
US6663900B2 (en) * 2002-02-01 2003-12-16 Kemin Foods, Lc Microcapsules having high carotenoid content
US6974592B2 (en) * 2002-04-11 2005-12-13 Ocean Nutrition Canada Limited Encapsulated agglomeration of microcapsules and method for the preparation thereof
US6936279B2 (en) * 2002-06-18 2005-08-30 Zeavision Llc Microcrystalline zeaxanthin with high bioavailability in oily carrier formulations
US7794764B2 (en) * 2002-10-15 2010-09-14 Mars Incorporated Preservation of process sensitive ingredients in an energy food product by product partitioning
DE60329971D1 (de) * 2002-07-08 2009-12-24 Mars Inc Energieriegel mit verbessertem geschmack
EP1559433A4 (en) * 2002-10-22 2009-11-04 Dainippon Sumitomo Pharma Co STABILIZED COMPOSITION
US8088363B2 (en) 2002-10-28 2012-01-03 Zeavision Llc Protection against sunburn and skin problems with orally-ingested high-dosage zeaxanthin
US20050067726A1 (en) * 2002-11-04 2005-03-31 Nianxi Yan Microcapsules having multiple shells and method for the preparation thereof
US9192586B2 (en) 2003-03-10 2015-11-24 Zeavision Llc Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders
EP1433387A1 (en) * 2002-12-26 2004-06-30 Adisseo France S.A.S. Solid granules containing carotenoids
CN1744827B (zh) 2003-01-31 2010-05-26 帝斯曼知识产权资产管理有限公司 包含类胡萝卜素的新颖的组合物
KR101143708B1 (ko) * 2003-03-27 2012-05-09 디에스엠 아이피 어셋츠 비.브이. 비드렛의 제조방법
JP4716982B2 (ja) * 2003-04-03 2011-07-06 ディーエスエム アイピー アセッツ ビー.ブイ. 脂溶性活性成分の粉末状配合物
US20070082066A1 (en) * 2003-05-07 2007-04-12 Gierhart Dennis L Use of zeaxanthin to reduce light hyper-sensitivity, photophobia, and medical conditions relating to light hyper-sensitivity
US20060159805A1 (en) * 2003-07-15 2006-07-20 Elger Funda Powderous formulations of fat-soluble active ingredients
CN1833052B (zh) * 2003-08-08 2010-10-20 昭和电工株式会社 带有黑膜的基质的生产方法和带有黑膜的基质
US7541166B2 (en) * 2003-09-19 2009-06-02 Microfluidic Systems, Inc. Sonication to selectively lyse different cell types
US7941211B2 (en) * 2003-11-17 2011-05-10 Zeavision, Llc. Preloading with macular pigment to improve photodynamic treatment of retinal vascular disorders
DE102004006106A1 (de) * 2004-02-06 2005-08-25 Basf Ag Verfahren zur Herstellung von Trockenpulvern eines oder mehrerer Carotinolde
US20050186307A1 (en) * 2004-02-20 2005-08-25 Axelrod Glen S. Pet food with enhanced nutritional value
CN1929751B (zh) * 2004-03-18 2011-06-22 帝斯曼知识产权资产管理有限公司 在挤出过程中稳定的食物产品用多不饱和脂肪酸组合物
ATE392882T1 (de) * 2004-07-09 2008-05-15 Mavi Sud S R L Formulierung auf basis von gelatine-glyzin und carotenoiden
US20060089411A1 (en) * 2004-08-07 2006-04-27 Gierhart Dennis L Treatment of Stargardt's disease and other lipofuscin disorders with combined retinaldehyde inhibitor and zeaxanthin
US8034450B2 (en) * 2005-01-21 2011-10-11 Ocean Nutrition Canada Limited Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof
EP1848729A2 (en) * 2005-01-27 2007-10-31 Ocean Nutrition Canada Limited Chromium-fatty acid compounds and methods of making and using thereof
ATE452120T1 (de) * 2005-01-27 2010-01-15 Ocean Nutrition Canada Ltd Fettsäure-benzenediol-derivate sowie herstellungs-und verwendungsverfahren dafür
US8592662B2 (en) 2005-02-11 2013-11-26 Kalamazoo Holdings, Inc. Capsicum variety exhibiting a hyper-accumulation of zeaxanthin and products derived therefrom
WO2006086707A2 (en) * 2005-02-11 2006-08-17 Kalamazoo Holdings, Inc. Extracts of asteraceae containing reduced levels of phototoxic thiophene derivatives and methods for preparing same
ATE492275T1 (de) * 2005-04-15 2011-01-15 Einstein Coll Med Vitamin k zur vorbeugung und behandlung von hautausschlag infolge einer anti-egfr-therapie
US9968120B2 (en) * 2006-05-17 2018-05-15 Dsm Nutritional Products Ag Homogenized formulations containing microcapsules and methods of making and using thereof
NZ572529A (en) * 2006-04-07 2010-11-26 Ocean Nutrition Canada Ltd Emulsions and microcapsules with substances having low interfacial tension, methods of making and using thereof
CN107362154B (zh) * 2006-06-05 2020-10-30 帝斯曼营养品股份公司 具有改进壳层的微胶囊
US8221809B2 (en) * 2006-06-22 2012-07-17 Martek Biosciences Corporation Encapsulated labile compound compositions and methods of making the same
CA2656613A1 (en) * 2006-07-03 2008-01-10 Genmab A/S Prevention of rash in patients undergoing anti-egfr therapy
ES2604081T3 (es) 2007-01-10 2017-03-02 Dsm Nutritional Products Ag Microcápsulas que incluyen proteína de guisante
DE102007015701A1 (de) * 2007-03-19 2008-09-25 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Neue pharmazeutische Zusammensetzungen für die Lipolyse und Verfahren zu deren Herstellung
TWI437962B (zh) * 2007-06-19 2014-05-21 Dsm Ip Assets Bv 微包封組成物、其製造方法、使用方法及其產物
PL2164975T3 (pl) 2007-07-06 2012-07-31 Basf Se Sposób produkcji stężonego wodnego roztworu glukozy z kukurydzy
US8815953B2 (en) * 2008-03-13 2014-08-26 Spectrum Pharmaceuticals, Inc. Formulations of vitamin K analogs for topical use
CN101971917A (zh) * 2010-08-14 2011-02-16 格特生物制药(天津)有限公司 一种畜禽用脂溶性维生素功能性饲料添加剂及其制备方法
WO2013148307A1 (en) 2012-03-27 2013-10-03 3M Innovative Properties Company Composite particles, methods of making, and articles including the same
CN103284290B (zh) * 2013-05-24 2015-04-08 肇庆巨元生化有限公司 一种良好的类胡萝卜素的微囊化方法
CN103315370B (zh) * 2013-05-24 2015-04-08 肇庆巨元生化有限公司 一种稳定的类胡萝卜素的微囊化方法
US20210339171A1 (en) * 2018-09-28 2021-11-04 Dow Global Technologies Llc Alkyl ether amine foam control compounds and methods of processing foodstuffs
JP2021107340A (ja) * 2019-12-27 2021-07-29 小林製薬株式会社 経口組成物
WO2022112587A1 (en) * 2020-11-30 2022-06-02 Dsm Ip Assets B.V. New formulations with reduced antioxidant content, their manufacture and use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB993138A (en) * 1961-11-22 1965-05-26 Pfizer & Co C Improvements in the preparation of vitamin-containing beadlets
DE3307095A1 (de) * 1983-03-01 1984-09-06 Degussa Ag, 6000 Frankfurt Mikrobiologisch hergestellte l-phenylalanin-dehydrogenase, verfahren zu ihrer gewinnung und ihre verwendung
EP0140255B1 (en) * 1983-10-14 1991-05-15 Sumitomo Pharmaceuticals Company, Limited Sustained-release injections
US4863950A (en) * 1985-03-12 1989-09-05 Morganti Pier F Medicinal formulation for promoting keratinogenesis and reducing seborrhea of the face and scalp
DE3610191A1 (de) * 1986-03-26 1987-10-01 Basf Ag Verfahren zur herstellung von feinteiligen, wasserdispergierbaren carotinoid-praeparationen
US4892889A (en) * 1986-11-18 1990-01-09 Basf Corporation Process for making a spray-dried, directly-compressible vitamin powder comprising unhydrolyzed gelatin
ATE64527T1 (de) * 1987-04-06 1991-07-15 Hoffmann La Roche Verfahren zur herstellung von vitaminpraeparaten.
US5153177A (en) * 1991-01-10 1992-10-06 Basf Corporation Process for incorporating a material in a crosslinked gelatin, and product therefrom

Also Published As

Publication number Publication date
CA2083754C (en) 2001-08-14
JPH0665062A (ja) 1994-03-08
CA2083754A1 (en) 1993-06-15
EP0547422B1 (de) 1996-03-13
US5356636A (en) 1994-10-18
DE59205688D1 (de) 1996-04-18
EP0547422A3 (en) 1994-05-11
IL103866A0 (en) 1993-04-04
IL103866A (en) 1996-12-05
JP2519008B2 (ja) 1996-07-31
DE4141351A1 (de) 1993-06-17
EP0547422A2 (de) 1993-06-23

Similar Documents

Publication Publication Date Title
DK0547422T3 (da) Stabile pulverformige vitamin- og/eller carotenoid-præparater og fremgangsmåde til deres fremstilling
DK56086D0 (da) 11beta-phenylgonaner, deres fremstilling og farmaceutiske praeparaterindeholdende dem
NO893678L (no) Cyklosporinholdige preparater og fremgangsmaate for deres fremstilling.
DK288184A (da) 13alfa-alkylgonaner, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK166007C (da) Farvet naeringsmiddelpraeparat, isaer til dekorationsbrug og fremgangsmaade til fremstilling af praeparatet
NO900577L (no) Cyklosporinholdige preparater og fremgangsmaate for deres fremstilling.
NO910003D0 (no) Vitamin e derivater og fremgangsmaate for deres fremstilling.
DK166583C (da) 1-pyrimidinyloxy-3-alkylamino-2-propanoler, deres fremstilling og farmaceutiske praeparater indeholdende disse
DK408786D0 (da) Fremgangsmaade til fremstilling af vitaminforstadier og vitaminer
DK304090A (da) Glycerolderivater, fremgangsmaade til deres fremstilling og terapeutiske praeparater indeholdende disse
DK488385A (da) N6-bicycloadenosinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende saadanne forbindelser
DK514989A (da) Enolestere og -ethere af 3-acyl-2-oxindol-1-carboxamider og deres anvendelse til fremstilling af laegemidler
DK261485D0 (da) Kosmetiske praeparater og fremgangsmaade til deres fremstilling
DK449989D0 (da) Quinolinderivater, deres fremstilling og laegemidler indeholdende disse derivater
DK299590A (da) Phospholipidderivater, fremgangsmaade til deres fremstilling og terapeutiske praeparater indeholdende disse
DK155692A (da) Benzofuranylimidazolderivater, fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende disse
DK443186D0 (da) Vitamin d derivater og fremgangsmaade til fremstilling deraf
DK347789A (da) Cysteinderivater, fremgangsmaade til fremstilling af dem og farmaceutiske praeparater indeholdende saadanne forbindelser
DK457386A (da) 4-substituerede catechol-derivater, fremgangsmaade til fremstillingderaf og farmaceutiske praeparater indeholdende saadanne derivater
DK9086A (da) Naphthalenderivater af benzonorbornen, fremgangsmaade til deres fremstilling og laegemidler og kosmetikpraeparater indeholdende saadanne forbindelser
DK352586A (da) 11-methylen-aestr-15-ener, fremgangsmaader til deres fremstilling og farmaceutiske praeparater indeholdende disse aestrener
DK180588A (da) Anti-tumor-virksomme praeparater og fremgangsmaade til deres fremstilling
DK276690D0 (da) Selenophenderivater, fremgangsmaade til deres fremstilling og terapeutiske praeparater indeholdende disse
DK19085D0 (da) Triazolylsubstituerede propanforbindelser, deres fremstilling og farmaceutiske praeparater, som indeholder dem
DK170290D0 (da) Fremgangsmaade til fremstilling af vandoploeseligt primycin og dets komponent samt farmaceutiske praeparater indeholdende dem