DK0545314T3 - Reagenssammensætninger og deres anvendelse ved identificeringen og karakteriseringen af reticulocytter i helblod. - Google Patents
Reagenssammensætninger og deres anvendelse ved identificeringen og karakteriseringen af reticulocytter i helblod.Info
- Publication number
- DK0545314T3 DK0545314T3 DK92120308T DK92120308T DK0545314T3 DK 0545314 T3 DK0545314 T3 DK 0545314T3 DK 92120308 T DK92120308 T DK 92120308T DK 92120308 T DK92120308 T DK 92120308T DK 0545314 T3 DK0545314 T3 DK 0545314T3
- Authority
- DK
- Denmark
- Prior art keywords
- reticulocytes
- cell
- erythrocytes
- measured
- hemoglobin
- Prior art date
Links
- 210000001995 reticulocyte Anatomy 0.000 title abstract 7
- 239000000203 mixture Substances 0.000 title abstract 5
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 4
- 238000012512 characterization method Methods 0.000 title 1
- 102000001554 Hemoglobins Human genes 0.000 abstract 5
- 108010054147 Hemoglobins Proteins 0.000 abstract 5
- 210000003743 erythrocyte Anatomy 0.000 abstract 5
- 238000010521 absorption reaction Methods 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000000975 dye Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 2
- 239000008280 blood Substances 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000007853 buffer solution Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- NZYCYASKVWSANA-UHFFFAOYSA-M new methylene blue Chemical compound [Cl-].CCNC1=C(C)C=C2N=C(C=C(C(NCC)=C3)C)C3=[S+]C2=C1 NZYCYASKVWSANA-UHFFFAOYSA-M 0.000 abstract 1
- CIYKWVNUXJDNNK-UHFFFAOYSA-N oxazine-750 Chemical compound N1=C2C3=CC=CC=C3C(NCC)=CC2=[O+]C2=C1C=C1CCCN3CCCC2=C13 CIYKWVNUXJDNNK-UHFFFAOYSA-N 0.000 abstract 1
- 239000000523 sample Substances 0.000 abstract 1
- 239000012488 sample solution Substances 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 239000002888 zwitterionic surfactant Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/101666—Particle count or volume standard or control [e.g., platelet count standards, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/107497—Preparation composition [e.g., lysing or precipitation, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Ecology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/802,593 US5350695A (en) | 1991-12-05 | 1991-12-05 | Methods for the identification and characterization of reticulocytes in whole blood |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0545314T3 true DK0545314T3 (da) | 1998-09-07 |
Family
ID=25184159
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92120308T DK0545314T3 (da) | 1991-12-05 | 1992-11-27 | Reagenssammensætninger og deres anvendelse ved identificeringen og karakteriseringen af reticulocytter i helblod. |
Country Status (12)
Country | Link |
---|---|
US (2) | US5350695A (de) |
EP (1) | EP0545314B1 (de) |
JP (1) | JP2802710B2 (de) |
KR (1) | KR100276144B1 (de) |
AT (1) | ATE161952T1 (de) |
AU (1) | AU2816592A (de) |
CA (1) | CA2077788C (de) |
DE (1) | DE69223930T2 (de) |
DK (1) | DK0545314T3 (de) |
ES (1) | ES2111599T3 (de) |
IL (1) | IL103054A (de) |
TW (1) | TW287232B (de) |
Families Citing this family (50)
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DE69432410T2 (de) * | 1993-05-14 | 2004-03-04 | Coulter International Corp., Miami | Retikulozyt bestimmungsverfahren und geraet, das lichtstreuungstechniken verwendet |
US5563070A (en) * | 1993-05-28 | 1996-10-08 | Omron Corporation | Method of counting reticulocytes |
JP3320869B2 (ja) * | 1993-12-22 | 2002-09-03 | シスメックス株式会社 | 白血球分析用試薬 |
DE69521006T2 (de) * | 1994-10-20 | 2001-09-20 | Sysmex Corp., Kobe | Reagenz und Verfahren zur Analyse fester Bestandteile im Harn |
US5691204A (en) * | 1995-04-21 | 1997-11-25 | Abbott Laboratories | Compositions and methods for the rapid analysis of reticulocytes |
DE19521231A1 (de) * | 1995-06-10 | 1996-12-12 | Boehringer Mannheim Gmbh | Neue Oxazinfarbstoffe und ihre Verwendung als Fluoreszenzmarker |
US5733784A (en) * | 1995-11-20 | 1998-03-31 | Abbott Laboratories | Reagent system and method for the differentiation and identification of reticulocytes |
US6025201A (en) * | 1995-12-28 | 2000-02-15 | Bayer Corporation | Highly sensitive, accurate, and precise automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
US5817519A (en) * | 1995-12-28 | 1998-10-06 | Bayer Corporation | Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples |
TW379284B (en) * | 1996-04-12 | 2000-01-11 | Toa Medical Electronics | Agent for detecting reticulocyte |
FR2759166B1 (fr) * | 1997-01-31 | 1999-04-23 | Abx Sa | Reactif de coloration pour la determination de cellules sanguines |
US6114173A (en) * | 1997-04-03 | 2000-09-05 | Bayer Corporation | Fully automated method and reagent composition therefor for rapid identification and characterization of reticulocytes erythrocytes and platelets in whole blood |
JP3350442B2 (ja) * | 1998-04-09 | 2002-11-25 | 科学技術振興事業団 | 顕微鏡システム |
US6060322A (en) * | 1998-10-20 | 2000-05-09 | Coulter International Corp. | Method for identification of reticulated cells |
US6271035B1 (en) | 1998-10-20 | 2001-08-07 | Coulter International Corp. | Methods and compositions for rapid staining of nucleic acids in whole cells |
JP3886271B2 (ja) * | 1998-11-27 | 2007-02-28 | シスメックス株式会社 | 赤芽球の分類計数用試薬及び分類計数方法 |
US6524858B1 (en) * | 1999-03-31 | 2003-02-25 | Bayer Corporation | Single channel, single dilution detection method for the identification and quantification of blood cells and platelets in a whole blood sample using an automated hematology analyzer |
US6784981B1 (en) * | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
KR100381725B1 (ko) * | 2000-12-29 | 2003-04-26 | (학)가톨릭학원가톨릭중앙의료원 | 용혈성 빈혈 검사 방법 |
US6630990B2 (en) * | 2001-06-05 | 2003-10-07 | Abbott Laboratories | Optical method and apparatus for red blood cell differentiation on a cell-by-cell basis, and simultaneous analysis of white blood cell differentiation |
DE10212960A1 (de) * | 2002-03-22 | 2003-10-23 | Gnothis Holding Sa Ecublens | Verwendung von Oxazin-Farbstoffen als Markierungsgruppen für die Einzelmolekülanalyse |
CA2428740A1 (en) | 2002-05-20 | 2003-11-20 | Bayer Corporation | Automated method and reagent therefor for assaying body fluid samples such as cerebrospinal fluid (csf) |
JP4417143B2 (ja) * | 2004-03-11 | 2010-02-17 | シスメックス株式会社 | 試料分析装置、プログラムおよびそのプログラムを記録した記録媒体 |
US7674598B2 (en) * | 2004-05-21 | 2010-03-09 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
US7625712B2 (en) * | 2004-05-21 | 2009-12-01 | Beckman Coulter, Inc. | Method for a fully automated monoclonal antibody-based extended differential |
US7110192B2 (en) * | 2005-01-12 | 2006-09-19 | Dako Denmark A/S | System and method for a composite lens for a flow cytometer |
US8653028B2 (en) | 2005-04-29 | 2014-02-18 | Rui Rong Yuan | Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators |
US9345745B2 (en) | 2005-04-29 | 2016-05-24 | Bo Wang | Methods for treating inflammatory disorders and traumatic brain injury using stabilized non-hematopoietic EPO short peptides |
EP1901846B1 (de) * | 2005-07-01 | 2015-01-14 | Honeywell International Inc. | Mikrofluidikkarte für die rbc-analyse |
US7804594B2 (en) * | 2006-12-29 | 2010-09-28 | Abbott Laboratories, Inc. | Method and apparatus for rapidly counting and identifying biological particles in a flow stream |
US7728974B2 (en) * | 2007-02-07 | 2010-06-01 | Cytopeia, Inc. | Enhanced detection system and method |
CN101349644B (zh) * | 2007-07-20 | 2012-06-27 | 深圳迈瑞生物医疗电子股份有限公司 | 一种白细胞分类试剂和其使用方法 |
US8102161B2 (en) * | 2007-09-25 | 2012-01-24 | Tdk Corporation | Stable output in a switching power supply by smoothing the output of the secondary coil |
US8137975B2 (en) * | 2007-10-29 | 2012-03-20 | Beckman Coulter, Inc. | Method for a rapid antibody-based analysis of platelet populations |
US8159670B2 (en) * | 2007-11-05 | 2012-04-17 | Abbott Laboratories | Method and apparatus for rapidly counting and identifying biological particles in a flow stream |
CN101475754A (zh) * | 2008-01-04 | 2009-07-08 | 深圳迈瑞生物医疗电子股份有限公司 | 不对称菁类荧光染料,组合物及在生物样品染色中的用途 |
CN101602762B (zh) * | 2008-06-10 | 2013-10-16 | 深圳迈瑞生物医疗电子股份有限公司 | 不对称菁类化合物、其制备方法及应用 |
CN101726579B (zh) * | 2008-10-17 | 2014-06-18 | 深圳迈瑞生物医疗电子股份有限公司 | 血液检测试剂和方法 |
CN101750274B (zh) * | 2008-12-17 | 2014-06-25 | 深圳迈瑞生物医疗电子股份有限公司 | 白细胞分类计数试剂、试剂盒以及白细胞分类计数的方法 |
US8467054B2 (en) | 2009-01-23 | 2013-06-18 | University Of Washington | Virtual core flow cytometry |
JP4969596B2 (ja) * | 2009-02-04 | 2012-07-04 | シスメックス株式会社 | 試料分析装置、試料分析方法およびプログラム |
CA2759392A1 (en) | 2009-04-27 | 2010-11-04 | Abbott Laboratories | Method for discriminating red blood cells from white blood cells by using forward scattering from a laser in an automated hematology analyzer |
CN101988082B (zh) * | 2009-07-31 | 2015-04-08 | 深圳迈瑞生物医疗电子股份有限公司 | 白细胞分类计数试剂、试剂盒及其制备方法和白细胞分类计数的方法 |
US8906308B2 (en) | 2010-01-15 | 2014-12-09 | Abbott Laboratories | Method for determining volume and hemoglobin content of individual red blood cells |
US9097704B2 (en) | 2010-05-05 | 2015-08-04 | Abbott Laboratories | Method for hematology analysis |
WO2016112035A1 (en) | 2015-01-08 | 2016-07-14 | University Of Washington | Systems and methods for immersion flow cytometry |
US10024780B2 (en) * | 2015-12-18 | 2018-07-17 | Abbott Laboratories (Diagnostics Division) | Methods for detecting events in a flow cytometer |
CA3022798A1 (en) | 2016-05-04 | 2017-11-09 | LabThroughput LLC | System and method for distinguishing blood components |
ES2975718T3 (es) | 2018-03-30 | 2024-07-12 | Idexx Lab Inc | Ensamblaje de óptica láser de citómetro de flujo |
EP4168773B1 (de) | 2020-06-17 | 2024-07-17 | Idexx Laboratories, Inc. | Durchflusszytometer und laseroptikanordnung dafür |
Family Cites Families (26)
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US3684377A (en) * | 1970-07-13 | 1972-08-15 | Bio Physics Systems Inc | Method for analysis of blood by optical analysis of living cells |
US3883247A (en) * | 1973-10-30 | 1975-05-13 | Bio Physics Systems Inc | Method for fluorescence analysis of white blood cells |
US4346018A (en) * | 1980-06-16 | 1982-08-24 | Coulter Electronics, Inc. | Multi-purpose blood diluent and lysing agent for differential determination of lymphoid-myeloid population of leukocytes |
US4325706A (en) * | 1980-08-15 | 1982-04-20 | Ortho Diagnostic Systems Inc. | Automated detection of platelets and reticulocytes in whole blood |
US4336029A (en) * | 1980-08-15 | 1982-06-22 | Ortho Diagnostic Systems Inc. | Method and reagents for quantitative determination of reticulocytes and platelets in whole blood |
US4412004A (en) * | 1981-06-26 | 1983-10-25 | Technicon Instruments Corporation | Method for treating red blood cells to effect sphering and reagent therefor |
IT1140209B (it) * | 1981-09-25 | 1986-09-24 | Anic Spa | Reagenti per immunoluorescenza e metodo per la loro preparazione |
US4571388A (en) * | 1983-01-24 | 1986-02-18 | Becton Dickinson And Company | Detection of reticulocytes |
US4490353A (en) * | 1983-07-13 | 1984-12-25 | Colgate-Palmolive Company | Antiplaque dentifrice with improved fluoride stability |
US4735504A (en) * | 1983-10-31 | 1988-04-05 | Technicon Instruments Corporation | Method and apparatus for determining the volume & index of refraction of particles |
US4575490A (en) * | 1984-02-29 | 1986-03-11 | Technicon Instruments Corporation | One step method for sphering and fixing whole blood erythrocytes |
WO1985005640A1 (en) * | 1984-05-31 | 1985-12-19 | Coulter Electronics, Inc. | A reagent system and method for identification, enumeration and examination of classes and subclasses of blood leukocytes |
US4652517A (en) * | 1984-06-11 | 1987-03-24 | Diagnostic Research Limited Partnership | Methods for the in vitro detection and identification of unknown pathogens or genetic entities |
JPS6179163A (ja) * | 1984-09-26 | 1986-04-22 | Toa Medical Electronics Co Ltd | 血球測定用試薬 |
JPS61280565A (ja) * | 1985-06-06 | 1986-12-11 | Toa Medical Electronics Co Ltd | フロ−サイトメトリ−用網状血球測定試薬 |
US4745071A (en) * | 1985-09-05 | 1988-05-17 | Sequoia-Turner Corporation | Method for the volumetric differentiation of blood cells types |
US4978624A (en) * | 1985-09-06 | 1990-12-18 | Technicon Instruments Corporation | Reagent for the determination of a differential white blood cell count |
US4707451A (en) * | 1985-09-18 | 1987-11-17 | Becton, Dickinson And Company | Detection of reticulocytes |
DE3677916D1 (de) * | 1985-11-01 | 1991-04-11 | Becton Dickinson Co | Nachweis von retikulozyten. |
US4883867A (en) * | 1985-11-01 | 1989-11-28 | Becton, Dickinson And Company | Detection of reticulocytes, RNA or DNA |
US5039613A (en) * | 1986-11-27 | 1991-08-13 | Toa Medical Electronics Co., Ltd. | Reagents used in a method of classifying leukocytes by flow cytometry |
JP2549665B2 (ja) * | 1987-07-31 | 1996-10-30 | 東亜医用電子株式会社 | フロ−サイトメトリ用網状赤血球測定試薬 |
JPH0746102B2 (ja) * | 1987-07-31 | 1995-05-17 | 東亜医用電子株式会社 | フロ−サイトメトリ用網状赤血球測定試薬 |
IT8921788A0 (it) * | 1989-09-21 | 1989-09-21 | Diesse Diagnostica | Reattivo utile per la rilevazione e la determinazione quantitativa dei leucociti in fluidi biologici. |
JPH0782013B2 (ja) * | 1989-10-27 | 1995-09-06 | 三菱化学株式会社 | 網状赤血球計数装置 |
US5075556A (en) * | 1989-12-01 | 1991-12-24 | Technicon Instruments Corporation | Acridine orange derivatives and their use in the quantitation of reticulocytes in whole blood |
-
1991
- 1991-12-05 US US07/802,593 patent/US5350695A/en not_active Expired - Lifetime
-
1992
- 1992-09-04 IL IL103054A patent/IL103054A/xx not_active IP Right Cessation
- 1992-09-09 CA CA002077788A patent/CA2077788C/en not_active Expired - Fee Related
- 1992-10-15 US US07/961,591 patent/US5438003A/en not_active Expired - Lifetime
- 1992-11-05 AU AU28165/92A patent/AU2816592A/en not_active Abandoned
- 1992-11-27 EP EP92120308A patent/EP0545314B1/de not_active Expired - Lifetime
- 1992-11-27 DK DK92120308T patent/DK0545314T3/da active
- 1992-11-27 DE DE69223930T patent/DE69223930T2/de not_active Expired - Fee Related
- 1992-11-27 ES ES92120308T patent/ES2111599T3/es not_active Expired - Lifetime
- 1992-11-27 AT AT92120308T patent/ATE161952T1/de not_active IP Right Cessation
- 1992-12-03 KR KR1019920023170A patent/KR100276144B1/ko not_active IP Right Cessation
- 1992-12-04 JP JP4350136A patent/JP2802710B2/ja not_active Expired - Lifetime
-
1993
- 1993-04-20 TW TW082103033A patent/TW287232B/zh active
Also Published As
Publication number | Publication date |
---|---|
JPH06180314A (ja) | 1994-06-28 |
DE69223930D1 (de) | 1998-02-12 |
AU2816592A (en) | 1993-06-10 |
IL103054A (en) | 1997-07-13 |
IL103054A0 (en) | 1993-02-21 |
ATE161952T1 (de) | 1998-01-15 |
EP0545314A1 (de) | 1993-06-09 |
KR100276144B1 (ko) | 2000-12-15 |
US5438003A (en) | 1995-08-01 |
CA2077788A1 (en) | 1993-06-06 |
US5350695A (en) | 1994-09-27 |
CA2077788C (en) | 1998-07-14 |
DE69223930T2 (de) | 1998-04-30 |
EP0545314B1 (de) | 1998-01-07 |
TW287232B (de) | 1996-10-01 |
ES2111599T3 (es) | 1998-03-16 |
JP2802710B2 (ja) | 1998-09-24 |
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