DK0532862T3 - Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af øjeninflammation - Google Patents
Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af øjeninflammationInfo
- Publication number
- DK0532862T3 DK0532862T3 DK92112716.3T DK92112716T DK0532862T3 DK 0532862 T3 DK0532862 T3 DK 0532862T3 DK 92112716 T DK92112716 T DK 92112716T DK 0532862 T3 DK0532862 T3 DK 0532862T3
- Authority
- DK
- Denmark
- Prior art keywords
- rapamycin
- treatment
- medicament
- manufacture
- ocular inflammation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73560491A | 1991-07-25 | 1991-07-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0532862T3 true DK0532862T3 (da) | 1996-02-19 |
Family
ID=24956475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK92112716.3T DK0532862T3 (da) | 1991-07-25 | 1992-07-24 | Anvendelse af rapamycin til fremstilling af et lægemiddel til behandling af øjeninflammation |
Country Status (20)
Country | Link |
---|---|
US (1) | US5387589A (da) |
EP (1) | EP0532862B1 (da) |
JP (1) | JP2568962B2 (da) |
KR (1) | KR100216768B1 (da) |
AT (1) | ATE133336T1 (da) |
AU (1) | AU653415B2 (da) |
CA (1) | CA2074641C (da) |
CZ (1) | CZ285660B6 (da) |
DE (1) | DE69207847T2 (da) |
DK (1) | DK0532862T3 (da) |
ES (1) | ES2083030T3 (da) |
HK (1) | HK1005705A1 (da) |
HU (1) | HU211218B (da) |
IE (1) | IE922430A1 (da) |
IL (1) | IL102414A (da) |
MX (1) | MX9204381A (da) |
NZ (1) | NZ243679A (da) |
RU (1) | RU2048812C1 (da) |
SK (1) | SK280511B6 (da) |
ZA (1) | ZA924953B (da) |
Families Citing this family (91)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0581959T3 (da) * | 1991-04-26 | 2001-01-29 | Fujisawa Pharmaceutical Co | Anvendelse af makrolidforbindelser til øjensygdomme |
AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US5496832A (en) * | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
BE1009856A5 (fr) * | 1995-07-14 | 1997-10-07 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule. |
TW427904B (en) * | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
GB9601120D0 (en) | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
US5912224A (en) * | 1996-02-22 | 1999-06-15 | The General Hospital Corporation | Methods and compositions for enhancing cellular response to TGF-β ligands |
JPH09278653A (ja) * | 1996-04-05 | 1997-10-28 | Santen Pharmaceut Co Ltd | 網膜疾患治療剤 |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
KR19990048077A (ko) * | 1997-12-08 | 1999-07-05 | 전원중 | 인조대리석 성형품의 제조방법 |
WO1999042104A1 (en) * | 1998-02-23 | 1999-08-26 | Fujisawa Pharmaceutical Co., Ltd. | Use of macrolide compounds for treating glaucoma |
JP2002520355A (ja) * | 1998-07-14 | 2002-07-09 | アルコン ラボラトリーズ, インコーポレイテッド | 非アレルギー性眼炎症障害を処置および眼新生血管形成を予防する医薬製造のための、11−(3−ジメチルアミノプロピリデン)−6,11−ジヒドロジベンズ[b,e]オキセピン−2−酢酸の使用 |
US7338976B1 (en) | 1998-08-14 | 2008-03-04 | Gpi Nil Holdings, Inc. | Heterocyclic esters or amides for vision and memory disorders |
US6399648B1 (en) | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
US6333340B1 (en) | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
US6218423B1 (en) | 1998-08-14 | 2001-04-17 | Gpi Nil Holdings, Inc. | Pyrrolidine derivatives for vision and memory disorders |
US6384056B1 (en) | 1998-08-14 | 2002-05-07 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters or ketones for vision and memory disorders |
US6339101B1 (en) | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6337340B1 (en) | 1998-08-14 | 2002-01-08 | Gpi Nil Holdings, Inc. | Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders |
US6506788B1 (en) | 1998-08-14 | 2003-01-14 | Gpi Nil Holdings, Inc. | N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders |
US6376517B1 (en) | 1998-08-14 | 2002-04-23 | Gpi Nil Holdings, Inc. | Pipecolic acid derivatives for vision and memory disorders |
US7410995B1 (en) | 1998-08-14 | 2008-08-12 | Gpi Nil Holdings Inc. | N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders |
US6335348B1 (en) | 1998-08-14 | 2002-01-01 | Gpi Nil Holdings, Inc. | Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders |
US7265150B1 (en) | 1998-08-14 | 2007-09-04 | Gpi Nil Holdings Inc. | Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
NZ513111A (en) * | 1998-12-24 | 2003-10-31 | R Tech Ueno Ltd | Agent for treating visual cell function disorder |
US6864232B1 (en) | 1998-12-24 | 2005-03-08 | Sucampo Ag | Agent for treating visual cell function disorder |
NZ515339A (en) * | 1999-04-30 | 2004-02-27 | R Tech Ueno Ltd | Use of macrolide compounds for the treatment of dry eye |
US7063857B1 (en) | 1999-04-30 | 2006-06-20 | Sucampo Ag | Use of macrolide compounds for the treatment of dry eye |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
EP1319008B1 (en) | 2000-09-19 | 2008-10-15 | Wyeth | Water soluble rapamycin esters |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
US6534693B2 (en) | 2000-11-06 | 2003-03-18 | Afmedica, Inc. | Surgically implanted devices having reduced scar tissue formation |
US20040018228A1 (en) * | 2000-11-06 | 2004-01-29 | Afmedica, Inc. | Compositions and methods for reducing scar tissue formation |
US20040241211A9 (en) * | 2000-11-06 | 2004-12-02 | Fischell Robert E. | Devices and methods for reducing scar tissue formation |
TWI286074B (en) | 2000-11-15 | 2007-09-01 | Wyeth Corp | Pharmaceutical composition containing CCI-779 as an antineoplastic agent |
TWI233359B (en) * | 2001-04-06 | 2005-06-01 | Wyeth Corp | Pharmaceutical composition for treating neoplasm |
ZA200603888B (en) * | 2001-06-01 | 2007-05-30 | Wyeth Corp | Antineoplastic combinations |
UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
US6680330B2 (en) | 2001-08-22 | 2004-01-20 | Wyeth | Rapamycin dialdehydes |
DE60206512T2 (de) | 2001-08-22 | 2006-06-22 | Wyeth | Rapamycin 29-enole |
CN1589144A (zh) * | 2001-11-19 | 2005-03-02 | 诺瓦提斯公司 | 子囊霉素用于治疗睑缘炎的用途 |
IL162734A0 (en) | 2002-02-01 | 2005-11-20 | Ariad Gene Therapeutics Inc | Phosphorus-containing compounds & uses thereof |
JP4265888B2 (ja) * | 2002-06-12 | 2009-05-20 | 株式会社リコー | 画像形成装置 |
DE60319118T2 (de) * | 2002-07-30 | 2009-02-05 | Wyeth | Parenterale formulierungen mit einem rapamycin hydroxyester |
US20040077677A1 (en) * | 2002-09-17 | 2004-04-22 | Wyeth | Oral formulations |
JP2006511475A (ja) * | 2002-09-18 | 2006-04-06 | トラスティーズ オブ ザ ユニバーシティ オブ ペンシルベニア | 脈絡膜新生血管症の抑制方法 |
US7354574B2 (en) | 2002-11-07 | 2008-04-08 | Advanced Ocular Systems Limited | Treatment of ocular disease |
AR042938A1 (es) * | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
KR20060006058A (ko) * | 2003-04-22 | 2006-01-18 | 와이어쓰 | 항신생물성 배합물 |
US7083802B2 (en) * | 2003-07-31 | 2006-08-01 | Advanced Ocular Systems Limited | Treatment of ocular disease |
US7585517B2 (en) * | 2003-09-18 | 2009-09-08 | Macusight, Inc. | Transscleral delivery |
US7083803B2 (en) | 2003-09-19 | 2006-08-01 | Advanced Ocular Systems Limited | Ocular solutions |
US7087237B2 (en) * | 2003-09-19 | 2006-08-08 | Advanced Ocular Systems Limited | Ocular solutions |
CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
WO2006041942A2 (en) * | 2004-10-04 | 2006-04-20 | Qlt Usa, Inc. | Ocular delivery of polymeric delivery formulations |
US8313763B2 (en) * | 2004-10-04 | 2012-11-20 | Tolmar Therapeutics, Inc. | Sustained delivery formulations of rapamycin compounds |
SI1848431T1 (sl) * | 2005-02-09 | 2016-05-31 | Santen Pharmaceutical Co., Ltd. | Tekoče formulacije za zdravljenje bolezni ali stanj |
US8663639B2 (en) * | 2005-02-09 | 2014-03-04 | Santen Pharmaceutical Co., Ltd. | Formulations for treating ocular diseases and conditions |
CA2602525A1 (en) * | 2005-03-21 | 2006-09-28 | Macusight, Inc. | Drug delivery systems for treatment of diseases or conditions |
EP1890652B1 (en) | 2005-05-13 | 2017-08-02 | Akkolens International B.V. | Intra-ocular artificial lens for iris-driven accommodation |
US20070014760A1 (en) * | 2005-07-18 | 2007-01-18 | Peyman Gholam A | Enhanced recovery following ocular surgery |
WO2007011880A2 (en) | 2005-07-18 | 2007-01-25 | Minu, L.L.C. | Enhanced ocular neuroprotection/neurostimulation |
US20070071754A1 (en) * | 2005-09-26 | 2007-03-29 | Peyman Gholam A | Method to ameliorate inflammation |
CN102579467A (zh) | 2005-11-14 | 2012-07-18 | 阿里亚德医药股份有限公司 | 雷帕霉素衍生物在治疗癌症中的用途 |
JP5528708B2 (ja) | 2006-02-09 | 2014-06-25 | 参天製薬株式会社 | 安定な製剤ならびにそれらを調製および使用する方法 |
US8222271B2 (en) * | 2006-03-23 | 2012-07-17 | Santen Pharmaceutical Co., Ltd. | Formulations and methods for vascular permeability-related diseases or conditions |
US20100081681A1 (en) * | 2006-08-16 | 2010-04-01 | Blagosklonny Mikhail V | Methods and compositions for preventing or treating age-related diseases |
JP6049160B2 (ja) | 2006-09-13 | 2016-12-27 | エリクシアー メディカル コーポレイション | 大環状ラクトン化合物およびその使用方法 |
WO2009048929A1 (en) | 2007-10-08 | 2009-04-16 | Lux Biosciences, Inc. | Ophthalmic compositions comprising calcineurin inhibitors or mtor inhibitors |
US7888370B2 (en) * | 2007-11-27 | 2011-02-15 | Alcon Research, Ltd. | Topical ophthalmic or otic solution formulations containing moxifloxacin hydrochloride and dexamethasone phosphate |
BRPI0919794A2 (pt) * | 2008-10-03 | 2015-12-15 | Elixir Medical Corp | dispositivo para uso intracorpóreo, e, composto |
EA023244B1 (ru) * | 2009-04-10 | 2016-05-31 | Хаян Ки | Способ предотвращения старения клеток |
MX338355B (es) * | 2009-06-09 | 2016-04-13 | Aurinia Pharmaceuticals Inc | Sistemas de suministro de farmaco topico para uso oftalmico. |
US8912215B2 (en) | 2011-12-13 | 2014-12-16 | Everon Biosciences, Inc. | Rapamycin composition |
US20140255355A1 (en) * | 2013-03-07 | 2014-09-11 | Stemnion, Inc. | Methods for treating blepharitis |
JP6944958B2 (ja) | 2016-05-25 | 2021-10-06 | 参天製薬株式会社 | 持続性浮腫を伴う滲出性加齢黄斑変性の処置のためのシロリムスの使用 |
MX2018016424A (es) | 2016-06-30 | 2019-08-12 | Durect Corp | Formulaciones de deposito. |
US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
JP2020507632A (ja) | 2017-02-10 | 2020-03-12 | マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. | ラパマイシン類似体 |
US20190224275A1 (en) | 2017-05-12 | 2019-07-25 | Aurinia Pharmaceuticals Inc. | Protocol for treatment of lupus nephritis |
AU2018283250B2 (en) | 2017-06-16 | 2022-09-01 | The Doshisha | mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof |
US20230055121A1 (en) | 2019-12-26 | 2023-02-23 | Santen Pharmaceutical Co., Ltd. | Aqueous suspension composition containing sirolimus or salt thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US3993749A (en) * | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
US5066493A (en) * | 1978-11-03 | 1991-11-19 | American Home Products Corporation | Rapamycin in treatment of tumors |
US4885171A (en) * | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
BE877700A (fr) * | 1978-11-03 | 1980-01-14 | Ayerst Mckenna & Harrison | Compositions pharmaceutiques a base de rapamycine pour le traitement de tumeurs carcinogenes |
US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
ZA905202B (en) * | 1989-07-05 | 1991-04-24 | Fujisawa Pharmaceutical Co | Aqueous liquid composition for external use |
-
1992
- 1992-07-03 ZA ZA924953A patent/ZA924953B/xx unknown
- 1992-07-03 IL IL10241492A patent/IL102414A/en not_active IP Right Cessation
- 1992-07-16 AU AU20350/92A patent/AU653415B2/en not_active Expired
- 1992-07-23 SK SK2307-92A patent/SK280511B6/sk unknown
- 1992-07-23 CZ CS922307A patent/CZ285660B6/cs not_active IP Right Cessation
- 1992-07-23 NZ NZ243679A patent/NZ243679A/en unknown
- 1992-07-24 DE DE69207847T patent/DE69207847T2/de not_active Expired - Lifetime
- 1992-07-24 JP JP4198692A patent/JP2568962B2/ja not_active Expired - Lifetime
- 1992-07-24 AT AT92112716T patent/ATE133336T1/de not_active IP Right Cessation
- 1992-07-24 HU HU9202448A patent/HU211218B/hu not_active IP Right Cessation
- 1992-07-24 MX MX9204381A patent/MX9204381A/es unknown
- 1992-07-24 DK DK92112716.3T patent/DK0532862T3/da active
- 1992-07-24 CA CA002074641A patent/CA2074641C/en not_active Expired - Lifetime
- 1992-07-24 KR KR1019920013296A patent/KR100216768B1/ko not_active IP Right Cessation
- 1992-07-24 RU SU925052757A patent/RU2048812C1/ru not_active IP Right Cessation
- 1992-07-24 EP EP92112716A patent/EP0532862B1/en not_active Expired - Lifetime
- 1992-07-24 ES ES92112716T patent/ES2083030T3/es not_active Expired - Lifetime
- 1992-07-24 IE IE243092A patent/IE922430A1/en not_active IP Right Cessation
- 1992-11-17 US US07/978,188 patent/US5387589A/en not_active Expired - Lifetime
-
1998
- 1998-06-04 HK HK98104905A patent/HK1005705A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ZA924953B (en) | 1993-04-28 |
US5387589A (en) | 1995-02-07 |
CA2074641A1 (en) | 1993-01-26 |
ATE133336T1 (de) | 1996-02-15 |
IL102414A (en) | 1996-08-04 |
CZ230792A3 (en) | 1993-02-17 |
EP0532862A1 (en) | 1993-03-24 |
CZ285660B6 (cs) | 1999-10-13 |
IL102414A0 (en) | 1993-01-14 |
CA2074641C (en) | 1999-05-04 |
AU653415B2 (en) | 1994-09-29 |
HUT63763A (en) | 1993-10-28 |
SK280511B6 (sk) | 2000-03-13 |
IE922430A1 (en) | 1993-01-27 |
SK230792A3 (en) | 1996-05-08 |
MX9204381A (es) | 1993-02-01 |
HU211218B (en) | 1995-11-28 |
HU9202448D0 (en) | 1992-10-28 |
NZ243679A (en) | 1997-06-24 |
RU2048812C1 (ru) | 1995-11-27 |
DE69207847T2 (de) | 1996-05-30 |
JPH05194212A (ja) | 1993-08-03 |
KR930001913A (ko) | 1993-02-22 |
KR100216768B1 (ko) | 1999-09-01 |
HK1005705A1 (en) | 1999-01-22 |
JP2568962B2 (ja) | 1997-01-08 |
AU2035092A (en) | 1993-01-28 |
EP0532862B1 (en) | 1996-01-24 |
ES2083030T3 (es) | 1996-04-01 |
DE69207847D1 (de) | 1996-03-07 |
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