DK0494071T3 - - Google Patents

Info

Publication number
DK0494071T3
DK0494071T3 DK92100014.7T DK92100014T DK0494071T3 DK 0494071 T3 DK0494071 T3 DK 0494071T3 DK 92100014 T DK92100014 T DK 92100014T DK 0494071 T3 DK0494071 T3 DK 0494071T3
Authority
DK
Denmark
Prior art keywords
alkyl
carboxy
phenyl
morpholino
chem
Prior art date
Application number
DK92100014.7T
Other languages
Danish (da)
English (en)
Inventor
Ichiro Shima
Hirokazu Tanaka
Keiji Hemmi
Keisuke Imai
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of DK0494071T3 publication Critical patent/DK0494071T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
  • Medicinal Preparation (AREA)
DK92100014.7T 1990-12-31 1992-01-02 DK0494071T3 (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
DK0494071T3 true DK0494071T3 (sv) 1997-05-12

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92100014.7T DK0494071T3 (sv) 1990-12-31 1992-01-02

Country Status (19)

Country Link
US (2) US5296591A (sv)
EP (1) EP0494071B1 (sv)
JP (1) JPH0699378B2 (sv)
KR (1) KR100192991B1 (sv)
CN (1) CN1040003C (sv)
AT (1) ATE151775T1 (sv)
AU (1) AU641577B2 (sv)
CA (1) CA2058560C (sv)
DE (1) DE69218977T2 (sv)
DK (1) DK0494071T3 (sv)
ES (1) ES2099755T3 (sv)
FI (1) FI106379B (sv)
GR (1) GR3023719T3 (sv)
HU (2) HU210263B (sv)
IE (1) IE914360A1 (sv)
MX (1) MX9102612A (sv)
NO (1) NO309274B1 (sv)
RU (1) RU2073684C1 (sv)
SG (1) SG50457A1 (sv)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
AU696292B2 (en) * 1994-06-02 1998-09-03 Merrell Pharmaceuticals Inc. Acylated enol derivatives as prodrugs of elastase inhibitors
EP0763055B1 (en) * 1994-06-02 1999-11-03 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
ES2421505T3 (es) * 1998-02-24 2013-09-03 Astellas Pharma Inc Preventivos/remedios contra el envejecimiento de la piel
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
KR20020050235A (ko) * 1999-10-12 2002-06-26 후지야마 아키라 난치성 창상의 치료제
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
WO2007140117A1 (en) * 2006-05-23 2007-12-06 Irm Llc Compounds and compositions as channel activating protease inhibitors
JP4101276B2 (ja) * 2006-08-25 2008-06-18 株式会社ステリック再生医科学研究所 慢性閉塞性肺疾患改善剤
EP2099454A4 (en) * 2006-11-17 2010-11-10 Abbott Lab AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS
JP5819305B2 (ja) * 2009-10-13 2015-11-24 リガンド・ファーマシューティカルズ・インコーポレイテッド 造血成長因子模倣小分子化合物およびそれらの使用
WO2014181788A1 (ja) * 2013-05-08 2014-11-13 キッセイ薬品工業株式会社 α－置換グリシンアミド誘導体
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
MX2018014932A (es) * 2016-06-24 2019-04-24 Pola Chem Ind Inc Preparacion externa para la piel para mejora de arrugas.
CA3080894A1 (en) 2017-11-15 2019-05-23 Pola Chemical Industries, Inc. Oil-based composition

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
EP0369391A3 (en) 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
IE914360A1 (en) 1992-07-01
MX9102612A (es) 1992-06-01
JPH0699378B2 (ja) 1994-12-07
NO309274B1 (no) 2001-01-08
EP0494071B1 (en) 1997-04-16
DE69218977D1 (de) 1997-05-22
US5296591A (en) 1994-03-22
DE69218977T2 (de) 1997-08-07
RU2073684C1 (ru) 1997-02-20
AU8985391A (en) 1992-07-02
KR100192991B1 (ko) 1999-06-15
SG50457A1 (en) 1998-07-20
HU211943A9 (en) 1996-01-29
ATE151775T1 (de) 1997-05-15
KR920011988A (ko) 1992-07-25
JPH04297446A (ja) 1992-10-21
US5430025A (en) 1995-07-04
EP0494071A3 (en) 1993-05-05
HU914153D0 (en) 1992-03-30
CA2058560A1 (en) 1992-07-01
NO920035L (no) 1992-07-01
CN1063108A (zh) 1992-07-29
FI915996A0 (fi) 1991-12-19
AU641577B2 (en) 1993-09-23
EP0494071A2 (en) 1992-07-08
FI915996A (fi) 1992-07-01
HUT60507A (en) 1992-09-28
GR3023719T3 (en) 1997-09-30
HU210263B (en) 1995-03-28
ES2099755T3 (es) 1997-06-01
CA2058560C (en) 2000-12-12
NO920035D0 (no) 1992-01-02
FI106379B (sv) 2001-01-31
CN1040003C (zh) 1998-09-30

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