DK0494071T3 - - Google Patents

Info

Publication number
DK0494071T3
DK0494071T3 DK92100014.7T DK92100014T DK0494071T3 DK 0494071 T3 DK0494071 T3 DK 0494071T3 DK 92100014 T DK92100014 T DK 92100014T DK 0494071 T3 DK0494071 T3 DK 0494071T3
Authority
DK
Denmark
Prior art keywords
alkyl
carboxy
phenyl
morpholino
chem
Prior art date
Application number
DK92100014.7T
Other languages
Danish (da)
English (en)
Inventor
Ichiro Shima
Hirokazu Tanaka
Keiji Hemmi
Keisuke Imai
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of DK0494071T3 publication Critical patent/DK0494071T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK92100014.7T 1990-12-31 1992-01-02 DK0494071T3 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
DK0494071T3 true DK0494071T3 (el) 1997-05-12

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92100014.7T DK0494071T3 (el) 1990-12-31 1992-01-02

Country Status (19)

Country Link
US (2) US5296591A (el)
EP (1) EP0494071B1 (el)
JP (1) JPH0699378B2 (el)
KR (1) KR100192991B1 (el)
CN (1) CN1040003C (el)
AT (1) ATE151775T1 (el)
AU (1) AU641577B2 (el)
CA (1) CA2058560C (el)
DE (1) DE69218977T2 (el)
DK (1) DK0494071T3 (el)
ES (1) ES2099755T3 (el)
FI (1) FI106379B (el)
GR (1) GR3023719T3 (el)
HU (2) HU210263B (el)
IE (1) IE914360A1 (el)
MX (1) MX9102612A (el)
NO (1) NO309274B1 (el)
RU (1) RU2073684C1 (el)
SG (1) SG50457A1 (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
DK0763055T3 (da) * 1994-06-02 2000-05-08 Merrell Pharma Inc Perflouralkylketon-inhibitorer af elastase og fremgangsmåde til fremstilling deraf
CN1149833A (zh) * 1994-06-02 1997-05-14 默里尔药物公司 作为弹性蛋白酶抑制剂前药的酰化烯醇衍生物
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
EP1057491B1 (en) * 1998-02-24 2013-06-19 Astellas Pharma Inc. Preventives/remedies for skin aging
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
CA2387199A1 (en) * 1999-10-12 2001-04-19 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
RU2419625C2 (ru) * 2006-05-23 2011-05-27 Айрм Ллк Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы
WO2008023446A1 (fr) * 2006-08-25 2008-02-28 Stelic Institute Of Regenerative Medicine, Stelic Institute & Co. Remède pour des bronchopneumopathies chroniques obstructives
CA2669917A1 (en) * 2006-11-17 2008-05-22 Dawn M. George Aminopyrrolidines as chemokine receptor antagonists
PT2488486T (pt) * 2009-10-13 2019-11-05 Ligand Pharm Inc Compostos de moléculas pequenas de mimética de fator de crescimento hematopoiético e utilizações dos mesmos
EP2995611B1 (en) 2013-05-08 2017-10-11 Kissei Pharmaceutical Co., Ltd. Alpha-substituted glycineamide derivative
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
MY194060A (en) * 2016-06-24 2022-11-10 Pola Chem Ind Inc External preparation for skin for wrinkle improvement
CN115192470A (zh) 2017-11-15 2022-10-18 宝丽化成工业有限公司 油性组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
HUT60507A (en) 1992-09-28
MX9102612A (es) 1992-06-01
CN1063108A (zh) 1992-07-29
FI915996A0 (fi) 1991-12-19
FI915996A (fi) 1992-07-01
DE69218977T2 (de) 1997-08-07
NO309274B1 (no) 2001-01-08
AU641577B2 (en) 1993-09-23
IE914360A1 (en) 1992-07-01
AU8985391A (en) 1992-07-02
US5430025A (en) 1995-07-04
EP0494071A2 (en) 1992-07-08
SG50457A1 (en) 1998-07-20
US5296591A (en) 1994-03-22
KR920011988A (ko) 1992-07-25
JPH0699378B2 (ja) 1994-12-07
HU210263B (en) 1995-03-28
CA2058560A1 (en) 1992-07-01
NO920035D0 (no) 1992-01-02
EP0494071B1 (en) 1997-04-16
HU914153D0 (en) 1992-03-30
JPH04297446A (ja) 1992-10-21
ATE151775T1 (de) 1997-05-15
GR3023719T3 (en) 1997-09-30
NO920035L (no) 1992-07-01
FI106379B (fi) 2001-01-31
DE69218977D1 (de) 1997-05-22
CA2058560C (en) 2000-12-12
EP0494071A3 (en) 1993-05-05
RU2073684C1 (ru) 1997-02-20
KR100192991B1 (ko) 1999-06-15
CN1040003C (zh) 1998-09-30
ES2099755T3 (es) 1997-06-01
HU211943A9 (en) 1996-01-29

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