US5208230A
(en)
*
|
1990-12-21 |
1993-05-04 |
Merrell Dow Pharmaceuticals |
Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
|
CA2057786C
(en)
*
|
1990-12-21 |
2002-06-18 |
Gary A. Flynn |
Amino and nitro containing tricyclic compounds useful as inhibitors or ace
|
AU657793B2
(en)
*
|
1991-09-27 |
1995-03-23 |
Merrell Pharmaceuticals Inc. |
Novel 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
|
US5457196A
(en)
*
|
1991-09-27 |
1995-10-10 |
Merrell Dow Pharmaceuticals Inc. |
2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE
|
US5455242A
(en)
*
|
1991-09-27 |
1995-10-03 |
Merrell Dow Pharmaceuticals Inc. |
Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
|
ZA927211B
(en)
*
|
1991-09-27 |
1993-03-24 |
Merrell Dow Pharma |
Novel carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE.
|
EP0534363B1
(en)
*
|
1991-09-27 |
1997-07-09 |
Merrell Pharmaceuticals Inc. |
Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
|
DE69317764T2
(de)
*
|
1992-02-14 |
1998-07-30 |
Merrell Pharmaceuticals Inc., Cincinnati, Ohio |
Aminoacetylmercaptoacetylamid derivate mit enkephalinase- und ace-hemmwirkung
|
US5552397A
(en)
*
|
1992-05-18 |
1996-09-03 |
E. R. Squibb & Sons, Inc. |
Substituted azepinone dual inhibitors of angiotensin converting enzyme and neutral exdopeptidase
|
EP0640086B1
(en)
*
|
1992-05-15 |
1999-08-04 |
Merrell Pharmaceuticals Inc. |
MERCAPTOACETYLAMIDO PYRIDAZO[ 1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
|
RU2124503C1
(ru)
*
|
1992-05-18 |
1999-01-10 |
И.Р.Сквибб энд Санз, Инк. |
Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
|
US5238932A
(en)
*
|
1992-05-20 |
1993-08-24 |
Merrell Dow Pharmaceuticals Inc. |
Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
|
US5298492A
(en)
*
|
1992-08-04 |
1994-03-29 |
Schering Corporation |
Diamino acid derivatives as antihypertensives
|
DE69326474T2
(de)
*
|
1992-08-24 |
2000-02-17 |
Merrell Pharmaceuticals Inc., Cincinnati |
Neue 2-substituierte tricyclische derivate von indan-2-mercaptoacetylamid verwendbar als enkephalinase inhibitoren
|
US5208236A
(en)
*
|
1992-09-23 |
1993-05-04 |
Schering Corporation |
N-(acylaminomethyl)glutaryl amino acids and use
|
US5504080A
(en)
*
|
1992-10-28 |
1996-04-02 |
Bristol-Myers Squibb Co. |
Benzo-fused lactams
|
JP3420766B2
(ja)
*
|
1992-10-30 |
2003-06-30 |
メレルダウファーマス−ティカルズ インコーポレイテッド |
エンケファリナーゼ及びaceの阻害剤として有用な新規なメルカプトアセチルアミド二環式ラクタム誘導体類
|
US5654294A
(en)
*
|
1993-05-13 |
1997-08-05 |
Bristol-Myers Squibb |
Spiro lactam dual action inhibitors
|
GB9310075D0
(en)
*
|
1993-05-17 |
1993-06-30 |
Fujisawa Pharmaceutical Co |
New mercapto-amide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
|
AU680512B2
(en)
*
|
1993-06-11 |
1997-07-31 |
Eisai Co. Ltd. |
Amino acid derivative
|
KR0156780B1
(ko)
*
|
1993-06-11 |
1998-11-16 |
나이토 하루오 |
아미노산 유도체
|
US5508272A
(en)
*
|
1993-06-15 |
1996-04-16 |
Bristol-Myers Squibb Company |
Compounds containing a fused bicycle ring and processes therefor
|
WO1995001353A1
(en)
*
|
1993-06-30 |
1995-01-12 |
Ciba-Geigy Ag |
Antihypertensive tricyclic azepine derivatives useful as inhibitors of enkephalinase and ace
|
ES2076096B1
(es)
*
|
1993-07-14 |
1996-03-16 |
Squibb & Sons Inc |
Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos.
|
US5362727A
(en)
*
|
1993-07-26 |
1994-11-08 |
Bristol-Myers Squibb |
Substituted azepino[2,1-a]isoquinoline compounds
|
US5525723A
(en)
*
|
1993-11-18 |
1996-06-11 |
Bristol-Myers Squibb Co. |
Compounds containing a fused multiple ring lactam
|
DK0745081T3
(da)
*
|
1994-02-14 |
2002-05-21 |
Merrell Pharma Inc |
Indan-2-mercaptoacetylamiddisulfidderivater, der er anvendelige som enkephalinase-inhibitorer
|
US5530013A
(en)
*
|
1994-02-14 |
1996-06-25 |
American Home Products Corporation |
Venlafaxine in the inducement of cognition enhancement
|
CA2183314C
(en)
*
|
1994-02-14 |
1999-08-31 |
Gary A. Flynn |
Novel 2-substituted indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase and ace
|
ATE177098T1
(de)
*
|
1994-02-14 |
1999-03-15 |
Merrell Pharma Inc |
Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
|
WO1995021854A1
(en)
*
|
1994-02-14 |
1995-08-17 |
Merrell Pharmaceuticals Inc. |
Novel mercaptoacetylamido 1,3,4,5-tetrahydro-benzo[c]azepin-3-one disulfide derivatives useful as inhibitors of enkephalinase and ace
|
US5484783A
(en)
*
|
1994-03-24 |
1996-01-16 |
Merrell Dow Pharmaceuticals Inc. |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide and benzazapine derivatives
|
EP0751783B1
(en)
*
|
1994-03-24 |
2000-02-02 |
Merrell Pharmaceuticals Inc. |
Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic use of aminoacetylmercapto derivatives
|
DE69531489T2
(de)
*
|
1994-03-24 |
2004-04-08 |
Merrell Pharmaceuticals Inc., Cincinnati |
Cholesterin senkende mercaptoacetylamiddisulfidderivate
|
US5616775A
(en)
*
|
1994-05-05 |
1997-04-01 |
Bristol-Myers Squibb Co. |
Process for preparing homocystein analogs useful as intermediates for compounds containing a fused bicyclic ring
|
SI0800527T1
(en)
*
|
1994-12-21 |
2000-08-31 |
Hoechst Marion Roussel, Inc. |
Novel processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
|
US5641880A
(en)
*
|
1994-12-21 |
1997-06-24 |
Hoechst Marion Roussel, Inc. |
Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
|
US5587375A
(en)
*
|
1995-02-17 |
1996-12-24 |
Bristol-Myers Squibb Company |
Azepinone compounds useful in the inhibition of ACE and NEP
|
US5877313A
(en)
|
1995-05-17 |
1999-03-02 |
Bristol-Myers Squibb |
Benzo-fused azepinone and piperidinone compounds useful in the inhibition of ACE and NEP
|
US5650408A
(en)
*
|
1995-06-07 |
1997-07-22 |
Karanewsky; Donald S. |
Thiazolo benzazepine containing dual action inhibitors
|
US5635504A
(en)
*
|
1995-06-07 |
1997-06-03 |
Bristol-Myers Squibb Co. |
Diazepine containing dual action inhibitors
|
WO1999065500A1
(en)
|
1998-06-17 |
1999-12-23 |
Bristol-Myers Squibb Company |
Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
|
SE9903028D0
(sv)
|
1999-08-27 |
1999-08-27 |
Astra Ab |
New use
|
KR20020040795A
(ko)
|
1999-08-30 |
2002-05-30 |
로버트 흐라이탁, 미쉘 베스트 |
심혈관 사고 예방용 레닌-안지오텐신 시스템 억제제의 용도
|
GB0119305D0
(en)
|
2001-04-12 |
2001-10-03 |
Aventis Pharma Gmbh |
Mercaptoacetylamide derivatives,a process for their preparation and their use
|
HU229612B1
(en)
*
|
2001-04-12 |
2014-03-28 |
Sanofi Aventis Deutschland |
Mercaptoacetylamide derivatives, process for their preparation and their use
|
AU2002348276A1
(en)
|
2001-11-16 |
2003-06-10 |
Bristol-Myers Squibb Company |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
|
US7009047B2
(en)
|
2002-03-19 |
2006-03-07 |
Sanofi-Aventis Deutschland Gmbh |
Ethane-1,2-diaminium bis[(2R)-2-bromo-3-phenylpropanoate], processes for its preparation and its use
|
DE10212198A1
(de)
*
|
2002-03-19 |
2003-10-02 |
Aventis Pharma Gmbh |
Ethan-1-diaminium-bis(2R)-2-brom-3-phenylpropanoat), Verfahren zu dessen Herstellung und dessen Verwendung
|
DE10229180A1
(de)
|
2002-06-28 |
2004-01-29 |
Aventis Pharma Deutschland Gmbh |
Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
|
ATE482747T1
(de)
|
2003-04-11 |
2010-10-15 |
High Point Pharmaceuticals Llc |
Neue amide derivate und deren pharmazeutische verwendungen
|
US7459474B2
(en)
|
2003-06-11 |
2008-12-02 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
US7371759B2
(en)
|
2003-09-25 |
2008-05-13 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
US7420059B2
(en)
|
2003-11-20 |
2008-09-02 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
US7273881B2
(en)
|
2004-01-16 |
2007-09-25 |
Bristol-Myers Squibb Company |
Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
|
JP5014983B2
(ja)
|
2004-05-07 |
2012-08-29 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
11−ベータヒドロキシステロイドデヒドロゲナーゼ阻害剤としてのピロリジン−2−オン及びピペリジン−2−オン誘導体
|
FR2872164B1
(fr)
*
|
2004-06-29 |
2006-11-17 |
Aventis Pharma Sa |
Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
|
DE602005017159D1
(de)
|
2004-08-30 |
2009-11-26 |
Janssen Pharmaceutica Nv |
Oxysteroid-dehydrogenase-inhibitoren
|
US7888381B2
(en)
|
2005-06-14 |
2011-02-15 |
Bristol-Myers Squibb Company |
Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity, and use thereof
|
US7592461B2
(en)
|
2005-12-21 |
2009-09-22 |
Bristol-Myers Squibb Company |
Indane modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
|
US7795291B2
(en)
|
2006-07-07 |
2010-09-14 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as anti-atherosclerotic, anti-dyslipidemic, anti-diabetic and anti-obesity agents and method
|
WO2008057862A2
(en)
|
2006-11-01 |
2008-05-15 |
Bristol-Myers Squibb Company |
MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-ϰB ACTIVITY AND USE THEREOF
|
EP2089389A2
(en)
|
2006-11-01 |
2009-08-19 |
Bristol-Myers Squibb Company |
Heterocyclic compounds as modulators of glucocorticoid receptor, ap-1, and/or nf-kappa-b activity
|
JP2010508358A
(ja)
|
2006-11-01 |
2010-03-18 |
ブリストル−マイヤーズ スクイブ カンパニー |
グルココルチコイド受容体、AP−1、および/またはNF−κB活性の調節剤、並びにその使用
|
US8969514B2
(en)
|
2007-06-04 |
2015-03-03 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
|
DK2170930T3
(da)
|
2007-06-04 |
2012-11-05 |
Synergy Pharmaceuticals Inc |
Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
|
WO2009158380A1
(en)
|
2008-06-24 |
2009-12-30 |
Bristol-Myers Squibb Company |
Cyclopentathiophene modulators of the glucocorticoid receptor, ap-1, and/or nf-kappa b activity and use thereof
|
ES2624828T3
(es)
|
2008-07-16 |
2017-07-17 |
Synergy Pharmaceuticals Inc. |
Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
|
MX2011005037A
(es)
|
2008-11-21 |
2011-06-16 |
High Point Pharmaceuticals Llc |
Compuestos de adamantilo benzamida.
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
AU2014235209B2
(en)
|
2013-03-15 |
2018-06-14 |
Bausch Health Ireland Limited |
Guanylate cyclase receptor agonists combined with other drugs
|
US9708367B2
(en)
|
2013-03-15 |
2017-07-18 |
Synergy Pharmaceuticals, Inc. |
Agonists of guanylate cyclase and their uses
|
KR102272746B1
(ko)
|
2013-06-05 |
2021-07-08 |
보슈 헬스 아일랜드 리미티드 |
구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
|
WO2015027021A1
(en)
|
2013-08-22 |
2015-02-26 |
Bristol-Myers Squibb Company |
Imide and acylurea derivatives as modulators of the glucocorticoid receptor
|