DK0478729T3 - Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil - Google Patents

Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Info

Publication number
DK0478729T3
DK0478729T3 DK91906948.4T DK91906948T DK0478729T3 DK 0478729 T3 DK0478729 T3 DK 0478729T3 DK 91906948 T DK91906948 T DK 91906948T DK 0478729 T3 DK0478729 T3 DK 0478729T3
Authority
DK
Denmark
Prior art keywords
derivatives
dkp
novel intermediates
diketopiperazine
aspartame
Prior art date
Application number
DK91906948.4T
Other languages
Danish (da)
English (en)
Inventor
John B Hill
Tse-Lok Ho
Mark R Johnson
Russell Klix
Gayle Webber
Robert A Erickson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of DK0478729T3 publication Critical patent/DK0478729T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK91906948.4T 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil DK0478729T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49824390A 1990-03-15 1990-03-15
US60665690A 1990-10-31 1990-10-31
US65878491A 1991-02-26 1991-02-26
US66480691A 1991-03-08 1991-03-08

Publications (1)

Publication Number Publication Date
DK0478729T3 true DK0478729T3 (da) 1996-09-16

Family

ID=27504394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91906948.4T DK0478729T3 (da) 1990-03-15 1991-03-12 Fremgangsmåde til fremstilling af aspartam ud fra et diketopiperazin, og hidtil ukendte mellemprodukter og derivater dertil

Country Status (16)

Country Link
EP (1) EP0478729B1 (no)
CN (1) CN1057835A (no)
AT (1) ATE141613T1 (no)
AU (1) AU628257B2 (no)
CA (1) CA2060515A1 (no)
CS (1) CS70091A2 (no)
DE (1) DE69121502T2 (no)
DK (1) DK0478729T3 (no)
ES (1) ES2091324T3 (no)
GR (1) GR3020839T3 (no)
HU (1) HUT60712A (no)
IE (1) IE910896A1 (no)
NO (1) NO920193D0 (no)
NZ (1) NZ237469A (no)
PT (1) PT97049B (no)
WO (1) WO1991014378A1 (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04234375A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物及びその製造法
JPH04234374A (ja) * 1990-12-27 1992-08-24 Ajinomoto Co Inc ジケトピペラジン誘導体の製造方法
JPH05117246A (ja) * 1991-10-23 1993-05-14 Ajinomoto Co Inc 新規２，５−ジオキソピペラジン化合物とその製造法及びα−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステル誘導体の製造法
US6465677B1 (en) 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
DE10019879A1 (de) * 2000-04-20 2001-10-25 Degussa Verfahren zur Herstellung von 2,5-Diketopiperazinen, neue 2,5-Diketopiperazine und deren Verwendung
AU7931301A (en) 2000-08-04 2002-02-18 Dmi Biosciences Inc Method of using diketopiperazines and composition containing them
GB2382346B (en) * 2000-08-04 2004-08-11 Dmi Biosciences Inc Method of synthesizing diketopiperazines
KR20120091266A (ko) 2003-05-15 2012-08-17 디엠아이 바이오사이언시스, 인크 Ｔ-세포 매개성 질환의 치료 방법
JP5856843B2 (ja) 2008-05-27 2016-02-10 アンピオ ファーマシューティカルズ，インコーポレイテッド ジケトピペラジンを用いた医薬組成物
US8507496B2 (en) 2010-09-07 2013-08-13 Dmi Acquisition Corp. Treatment of diseases
EP3701921A1 (en) 2011-10-10 2020-09-02 Ampio Pharmaceuticals, Inc. Implantable medical devices with increased immune tolerance, and methods for making and implanting
EA028343B1 (ru) 2011-10-10 2017-11-30 Ампио Фармасьютикалз, Инк. Лечение дегенеративного заболевания сустава
WO2013063413A1 (en) 2011-10-28 2013-05-02 Ampio Pharmaceuticals, Inc. Treatment of rhinitis
NZ712630A (en) 2013-03-15 2021-07-30 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
WO2016028790A1 (en) 2014-08-18 2016-02-25 Ampio Pharmaceuticals, Inc. Treatment of joint conditions
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES
KR20190095420A (ko) * 2016-12-21 2019-08-14 산토리 홀딩스 가부시키가이샤 시클로아스파르틸글리신, 글루코오스, 및 말토오스를 함유하는 음식품

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2038106A1 (de) * 1970-07-31 1972-02-10 Henkel & Cie Gmbh Aktivatoren fuer Perverbindungen
JPS58185545A (ja) * 1982-04-22 1983-10-29 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルまたはその塩酸塩の製法
IT1197461B (it) * 1983-05-13 1988-11-30 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenil-alanina
JPS60174799A (ja) * 1984-02-21 1985-09-09 Ajinomoto Co Inc α−Ｌ−アスパルチル−Ｌ−フエニルアラニンメチルエステルの製造法
AU586669B2 (en) * 1985-03-29 1989-07-20 Mitsui Toatsu Chemicals Inc. Preparation process of ```-L-aspartyl-L-phenylalanine methyl ester or hydrochloride thereof
JPH0647600B2 (ja) * 1985-06-04 1994-06-22 味の素株式会社 β−アスパルチルフエニルアラニン誘導体のα−アスパルチルフエニルアラニン誘導体への変換法
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
DE3600731A1 (de) * 1986-01-13 1987-07-16 Green Cross Korea Verfahren zur herstellung von (alpha)-l-aspartyl-l-phenylalaninmethylester
US4992552A (en) * 1988-08-31 1991-02-12 Eastman Kodak Company Process for preparation of amino acids

Also Published As

Publication number Publication date
AU7564891A (en) 1991-10-21
PT97049B (pt) 1998-07-31
CN1057835A (zh) 1992-01-15
PT97049A (pt) 1991-12-31
NO920193L (no) 1992-01-15
GR3020839T3 (en) 1996-11-30
EP0478729A4 (en) 1993-06-16
IE910896A1 (en) 1991-09-25
EP0478729A1 (en) 1992-04-08
EP0478729B1 (en) 1996-08-21
DE69121502T2 (de) 1997-01-16
WO1991014378A1 (en) 1991-10-03
HUT60712A (en) 1992-10-28
DE69121502D1 (de) 1996-09-26
ATE141613T1 (de) 1996-09-15
ES2091324T3 (es) 1996-11-01
NO920193D0 (no) 1992-01-15
CA2060515A1 (en) 1991-09-16
CS70091A2 (en) 1991-10-15
NZ237469A (en) 1993-08-26
AU628257B2 (en) 1992-09-10

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