DK0470192T3 - Forbedret immunoassay, der indbefatter lyofiliseret reaktantblanding - Google Patents

Forbedret immunoassay, der indbefatter lyofiliseret reaktantblanding

Info

Publication number
DK0470192T3
DK0470192T3 DK90908003.8T DK90908003T DK0470192T3 DK 0470192 T3 DK0470192 T3 DK 0470192T3 DK 90908003 T DK90908003 T DK 90908003T DK 0470192 T3 DK0470192 T3 DK 0470192T3
Authority
DK
Denmark
Prior art keywords
polyethylene glycol
mixture
isooctylphenyl ether
reactant mixture
sugar
Prior art date
Application number
DK90908003.8T
Other languages
English (en)
Inventor
Francis X Cole
Original Assignee
Hygeia Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hygeia Sciences Ltd filed Critical Hygeia Sciences Ltd
Application granted granted Critical
Publication of DK0470192T3 publication Critical patent/DK0470192T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/962—Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
DK90908003.8T 1989-04-28 1990-04-16 Forbedret immunoassay, der indbefatter lyofiliseret reaktantblanding DK0470192T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/344,575 US5102788A (en) 1988-11-21 1989-04-28 Immunoassay including lyophilized reactant mixture

Publications (1)

Publication Number Publication Date
DK0470192T3 true DK0470192T3 (da) 1997-10-27

Family

ID=23351108

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90908003.8T DK0470192T3 (da) 1989-04-28 1990-04-16 Forbedret immunoassay, der indbefatter lyofiliseret reaktantblanding

Country Status (9)

Country Link
US (1) US5102788A (da)
EP (1) EP0470192B1 (da)
JP (1) JP2823353B2 (da)
AT (1) ATE159047T1 (da)
CA (1) CA2053885A1 (da)
DE (1) DE69031561T2 (da)
DK (1) DK0470192T3 (da)
ES (1) ES2110415T3 (da)
WO (1) WO1990013637A1 (da)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8826429D0 (en) * 1988-11-11 1988-12-14 Univ Leeds Ind Service Ltd Enzyme stabilisation systems
US5376556A (en) * 1989-10-27 1994-12-27 Abbott Laboratories Surface-enhanced Raman spectroscopy immunoassay
US5252496A (en) 1989-12-18 1993-10-12 Princeton Biomeditech Corporation Carbon black immunochemical label
DE4034509A1 (de) * 1990-10-30 1992-05-07 Boehringer Mannheim Gmbh Immunologisches praezipitationsverfahren zur bestimmung eines bindefaehigen analyten sowie reagenz zur durchfuehrung dieses verfahrens
IT1245761B (it) * 1991-01-30 1994-10-14 Alfa Wassermann Spa Formulazioni farmaceutiche contenenti glicosaminoglicani assorbibili per via orale.
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
CA2120701A1 (en) * 1991-10-11 1993-04-15 Sharon M. Devereaux Unit-of-use reagent composition for specific binding assays
CA2119125A1 (en) * 1991-10-11 1993-04-15 Sharon M. Devereaux Unit-of-use reagent compositions for specific binding assays
US5298406A (en) * 1992-09-14 1994-03-29 E. I. Du Pont De Nemours And Company Formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes
US5354654A (en) * 1993-07-16 1994-10-11 The United States Of America As Represented By The Secretary Of The Navy Lyophilized ligand-receptor complexes for assays and sensors
ES2220914T3 (es) * 1993-08-31 2004-12-16 Roche Diagnostics Corporation Reactivo y metodo para su suso.
JP4142095B2 (ja) * 1994-06-02 2008-08-27 クアドラント・ドラツグ・デリバリー・リミテツド 各種物質の再水和または融解時の凝集を防止する方法及び該方法により得られる組成物
US5681754A (en) * 1996-06-07 1997-10-28 Abbott Laboratories Method for improving the performance of an immunoreagent in an immunoassay
US5876944A (en) * 1996-06-10 1999-03-02 Bayer Corporation Method for amplification of the response signal in a sandwich immunoassay
US5895765A (en) * 1997-06-30 1999-04-20 Bayer Corporation Method for the detection of an analyte by immunochromatography
US6833275B1 (en) * 1997-07-22 2004-12-21 Roche Diagnostics Gmbh Gold conjugates containing detergent
DE19731469A1 (de) * 1997-07-22 1999-01-28 Boehringer Mannheim Gmbh Detergenzhaltige Goldkonjugate
FR2781055B1 (fr) * 1998-07-09 2000-10-13 Immunotech Sa Reactif et methode pour la permeabilisation et l'identification des erythrocytes
US7141436B2 (en) * 1999-11-03 2006-11-28 Science And Technology Corp. Immunoassay and reagents and kits for performing the same
US6699722B2 (en) 2000-04-14 2004-03-02 A-Fem Medical Corporation Positive detection lateral-flow apparatus and method for small and large analytes
AT5044U1 (de) * 2001-05-10 2002-02-25 Medsystems Diagnostics Gmbh Quantitativer einschritt immuntest in lyophilisierter form
US20030017620A1 (en) * 2001-06-21 2003-01-23 Carron Keith T. Lyophilization of colloidal metals for surface enhanced Raman scattering
US7776610B2 (en) * 2003-05-07 2010-08-17 University Of Wyoming Cyanide and related species detection with metal surfaces
DE10323901A1 (de) * 2003-05-26 2005-01-05 Institut Virion/Serion Gmbh Verfahren und Testmittel zur Untersuchung und/oder zum Nachweis von Biomolekülen und/oder Wirkstoffen in Flüssigkeitsproben
US20040241879A1 (en) * 2003-06-02 2004-12-02 Robinson Joseph R. Assay device and method
US7993933B2 (en) * 2004-05-06 2011-08-09 University Of Wyoming Cyanide and related species detection with metal surfaces
CA2587945A1 (en) * 2004-11-17 2007-04-12 Bioveris Electrochemiluminescent assay
US20060275841A1 (en) * 2004-12-20 2006-12-07 Martin Blankfard Assay method and apparatus with reduced sample matrix effects
US7763418B2 (en) * 2005-07-05 2010-07-27 Cytoskeleton, Inc. Detection of Rho proteins
GB0701253D0 (en) 2007-01-23 2007-02-28 Diagnostics For The Real World Nucleic acid amplification and testing
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
US7816135B2 (en) 2007-07-05 2010-10-19 Becton, Dickinson And Company Method of analyzing lymphocytes
WO2009020612A1 (en) * 2007-08-06 2009-02-12 Stb Lifesaving Technologies, Inc. Methods and dressing for sealing internal injuries
WO2010006201A2 (en) * 2008-07-10 2010-01-14 Abaxis, Inc. Methods of reducing non-specific interaction in metal nanoparticle assays
EP2198964B8 (de) * 2008-11-06 2013-04-24 F. Hoffmann-La Roche AG Verfahren zum Bereitstellen eines getrockneten Reagenz in einem mikrofluidischen System
WO2010065781A2 (en) 2008-12-03 2010-06-10 Abaxis, Inc. Lateral flow strip assay with immobilized conjugate
US8377643B2 (en) * 2009-03-16 2013-02-19 Abaxis, Inc. Split flow device for analyses of specific-binding partners
US8039272B2 (en) * 2009-04-01 2011-10-18 Nova Biomedical Rapid quantification assay involving concentrated and ligand-coated gold colloid
CN102004146B (zh) * 2009-09-03 2014-09-10 艾博生物医药(杭州)有限公司 一种混合标记物质和标记方法及其应用
EP2513650A4 (en) 2009-12-17 2013-12-18 Abay Sa NEW ANALYTE DETECTION ASSAYS IN SAMPLES AND KITS AND COMPOSITIONS RELATING THERETO
CA2805720A1 (en) 2010-06-17 2011-12-22 Abaxis, Inc. Rotors for immunoassays
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
EP3411499B1 (en) 2016-02-05 2023-11-08 Gen-Probe Incorporated Dried amplification compositions
JP6801381B2 (ja) * 2016-11-07 2020-12-16 東ソー株式会社 凍結乾燥状態の検体前処理試薬
JP2017083461A (ja) * 2016-12-21 2017-05-18 イノーバ・バイオサイエンシズ・リミテッドＩｎｎｏｖａ Ｂｉｏｓｃｉｅｎｃｅｓ Ｌｔｄ 共役反応
WO2018213811A1 (en) 2017-05-19 2018-11-22 Gen-Probe Incorporated Dried compositions containing flap endonuclease
WO2026006318A1 (en) 2024-06-24 2026-01-02 Amplifidx, Inc. Point-of-care bioassay systems and methods of making and using the same

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2908614A (en) * 1954-08-10 1959-10-13 Glaxo Lab Ltd Use of dextran in freeze-drying process
US3378443A (en) * 1966-04-05 1968-04-16 American Cyanamid Co Anhydrous liquid suspensions of biologics
US3423290A (en) * 1966-08-03 1969-01-21 Nasa Lyophilized reaction mixtures
NL154600B (nl) * 1971-02-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen.
US3652761A (en) * 1969-09-04 1972-03-28 Corning Glass Works Immunochemical composites and antigen or antibody purification therewith
GB1354286A (en) * 1970-05-13 1974-05-22 Bagshawe K D Performance of routine chemical reactions
DE2310964A1 (de) * 1973-03-02 1974-09-05 Schering Ag Antigen- bzw. antigen-proteinkonjugatbeschichtete erythrocytenpraeparation
US3880715A (en) * 1973-06-13 1975-04-29 Syva Co Immunoassay for haptens
CH582884A5 (da) * 1973-12-10 1976-12-15 Hoffmann La Roche
US4017597A (en) * 1974-10-30 1977-04-12 Monsanto Company Unitized solid phase immunoassay kit and method
DE2460903C3 (de) * 1974-12-21 1981-12-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 3,3',5,5'-Tetraalkylbenzidine
NL7501215A (nl) * 1975-02-01 1976-08-03 Akzo Nv Methode voor het aantonen en bepalen van een antigeen of antilichaam.
DE2508176A1 (de) * 1975-02-26 1976-09-09 Reinhard Dr Fuhr Verfahren zur herstellung von lyophilisierte antigene tragenden objekttraegern und dgl. fuer biologische, insbesondere medizinische, vor allem diagnostische zwecke
US4062933A (en) * 1975-05-27 1977-12-13 Mallinckrodt, Inc. Colloidal compositions with protective agents suitable for radioactive labeling
US4157280A (en) * 1975-09-29 1979-06-05 Cordis Corporation Test set for detecting the presence of antigens associated with hepatitis
SU554867A1 (ru) * 1975-12-16 1977-04-25 Ростовский-На-Дону Государственный Научно-Исследовательский Противочумный Институт Способ получени диагностики дл проведени серологических реакций
CH625626A5 (en) * 1976-03-25 1981-09-30 Hoffmann La Roche Process for the preparation of stable immunological reagents
US4094647A (en) * 1976-07-02 1978-06-13 Thyroid Diagnostics, Inc. Test device
US4108974A (en) * 1976-08-27 1978-08-22 Bio-Rad Laboratories, Inc. Radioimmunoassay for thyroid hormone
NL7610608A (nl) * 1976-09-24 1978-03-29 Akzo Nv Werkwijze voor het stabiliseren van peroxidase- -bevattende composities.
GB1572220A (en) * 1976-10-07 1980-07-30 Mochida Pharm Co Ltd Immunochemical process of measuring physiologically active substances
US4200690A (en) * 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
FR2388275A1 (fr) * 1977-04-22 1978-11-17 Biotrol Sa Lab Reactifs enzymatiques stabilises pour analyses et procede pour leur obtention
US4115535A (en) * 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4188371A (en) * 1977-09-28 1980-02-12 Corning Glass Works Immunological detection of Neisseria bacteria via labelled antibodies
DE2748132A1 (de) * 1977-10-27 1979-05-03 Behringwerke Ag Stabilisator fuer polysaccharid
SE7712244L (sv) * 1977-10-31 1979-05-01 Jonsson U R S Forfarande for framstellning av preparationer av avdodade bakterier
SU943280A1 (ru) * 1978-05-29 1982-07-15 Институт биоорганической химии им.М.М.Шемякина Способ консервации иммобилизованных ферментов
IL55564A (en) * 1978-09-13 1981-12-31 Ames Yissum Ltd Method for the quantitative determination of antigens in aqueous solutions
US4273868A (en) * 1979-02-23 1981-06-16 Miles Laboratories, Inc. Color stable glucose test
US4256833A (en) * 1979-01-08 1981-03-17 Majid Ali Enzyme immunoassay for allergic disorders
US4230664A (en) * 1979-01-23 1980-10-28 Technion Research & Development Foundation Ltd. Test pack kit for immunoassay
US4287300A (en) * 1979-07-26 1981-09-01 Syva Company Charge effects in enzyme immunoassays
FI792576A7 (fi) * 1979-08-20 1981-01-01 Orion Yhtymae Oy Parannettu entsyymi-immunologinen määritysmenetelmä.
US4280816A (en) * 1979-10-25 1981-07-28 Nasik Elahi Macroencapsulated immunosorbent assay technique and element therefor
US4340395A (en) * 1979-11-13 1982-07-20 Miles Laboratories, Inc. Stabilization of benzidine-type indicators with various enhancers
US4299916A (en) * 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4391904A (en) * 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
EP0111216A3 (en) * 1980-03-31 1985-01-16 Takeda Chemical Industries, Ltd. Method for enzyme immunoassay and peptide-enzyme conjugate, its lyophilizate, antibody and kit therefor
EP0042755B1 (en) * 1980-06-20 1988-08-24 Unilever Plc Processes and apparatus for carrying out specific binding assays
US4486530A (en) * 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4444879A (en) * 1981-01-29 1984-04-24 Science Research Center, Inc. Immunoassay with article having support film and immunological counterpart of analyte
EP0070992B1 (de) * 1981-07-30 1985-01-09 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Stabilisierung von Peroxidase in einem flüssigen Medium und so stabilisiertes Medium
US4386224A (en) * 1981-08-31 1983-05-31 Monsanto Company Color stabilization of monoalkyl phenols
US4446232A (en) * 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
US4459359A (en) * 1981-11-19 1984-07-10 New York Blood Center, Inc. Sensitive immunoassays of antigens or antibodies sequestered within immune complexes
US4458014A (en) * 1982-01-11 1984-07-03 Forsyth Dental Infirmary For Children Serological method for the identification of microorganisms
US4681782A (en) * 1982-03-31 1987-07-21 Biostar Medical Products, Inc. Article for determining the presence of immune complexes
US4503143A (en) * 1982-08-20 1985-03-05 Btc Diagnostics Limited Partnership Enzyme immunoassay with two-part solution of tetramethylbenzidine as chromogen
US4457916A (en) * 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
US4459358A (en) * 1982-12-29 1984-07-10 Polaroid Corporation Multilayer element for analysis
JPS6035263A (ja) * 1983-08-05 1985-02-23 Wako Pure Chem Ind Ltd 不溶性担体に固定化された免疫活性物質の安定化法及び該物質を構成単位として含む生理活性物質測定用試薬
US4545452A (en) * 1983-09-26 1985-10-08 Caterpillar Tractor Co. Axle housing mounting bracket
GB8328918D0 (en) * 1983-10-28 1983-11-30 Unilever Plc Alkaline phosphatase
US4615972A (en) * 1983-11-04 1986-10-07 Immuno Concepts, Inc. Stabilization of indicators for detecting enzyme activity
US4931385A (en) * 1985-06-24 1990-06-05 Hygeia Sciences, Incorporated Enzyme immunoassays and immunologic reagents
DE3682047D1 (de) * 1985-07-09 1991-11-21 Quadrant Bioresources Ltd Beschuetzung von proteinen und aehnlichem.
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
DE68920693T2 (de) * 1988-03-30 1995-05-24 Toray Industries Gefriergetrocknete Zusammensetzung, die ein mit Meerrettichperoxydase markiertes Fab'-Fragment eines gegen menschliches Beta-Interferon gerichteten Antikörpers und Trehalose enthält; EIA Kit, der diese Zusammensetzung enthält.

Also Published As

Publication number Publication date
CA2053885A1 (en) 1990-10-29
DE69031561D1 (de) 1997-11-13
JPH05500854A (ja) 1993-02-18
ATE159047T1 (de) 1997-10-15
EP0470192A1 (en) 1992-02-12
ES2110415T3 (es) 1998-02-16
DE69031561T2 (de) 1998-02-19
WO1990013637A1 (en) 1990-11-15
JP2823353B2 (ja) 1998-11-11
EP0470192B1 (en) 1997-10-08
EP0470192A4 (en) 1992-03-11
US5102788A (en) 1992-04-07

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