FR2413400A1 - Produits biochimiques insolubilises et stabilises et leur application en tant que reactifs immunochimiques - Google Patents

Produits biochimiques insolubilises et stabilises et leur application en tant que reactifs immunochimiques

Info

Publication number
FR2413400A1
FR2413400A1 FR7836231A FR7836231A FR2413400A1 FR 2413400 A1 FR2413400 A1 FR 2413400A1 FR 7836231 A FR7836231 A FR 7836231A FR 7836231 A FR7836231 A FR 7836231A FR 2413400 A1 FR2413400 A1 FR 2413400A1
Authority
FR
France
Prior art keywords
insolubilized
stabilized
biochemicals
application
immunochemical reagents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7836231A
Other languages
English (en)
Other versions
FR2413400B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Byk Mallinckrodt Chemische Produkte GmbH
Original Assignee
Byk Mallinckrodt Chemische Produkte GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Mallinckrodt Chemische Produkte GmbH filed Critical Byk Mallinckrodt Chemische Produkte GmbH
Publication of FR2413400A1 publication Critical patent/FR2413400A1/fr
Application granted granted Critical
Publication of FR2413400B1 publication Critical patent/FR2413400B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/44—Antibodies bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/08—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
    • C12N11/082—Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C12N11/087—Acrylic polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/964—Chemistry: molecular biology and microbiology including enzyme-ligand conjugate production, e.g. reducing rate of nonproductive linkage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/811—Peptides or proteins is immobilized on, or in, an inorganic carrier

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • Inorganic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PRODUITS BIOCHIMIQUES INSOLUBILISES ET STABILISES, LEUR PREPARATION ET LEURS UTILISATIONS. ON FIXE UNE SUBSTANCE BIOCHIMIQUE, PAR EXEMPLE UN ANTIGENE, UN ANTICORPS, UNE HORMONE, UN AMINOACIDE, UN HAPTENE, UNE PROTEINE, UN ENZYME OU UNE SUBSTANCE ANALOGUE PAR LIAISONS COVALENTES SUR UNE COUCHE D'HETEROPOLYCONDENSAT DE SILICE APPLIQUEE SUR UN SUPPORT COHERENT, PAR EXEMPLE DU VERRE. LES PRODUITS BIOCHIMIQUES INSOLUBILISES ET STABILISES SELON L'INVENTION PEUVENT ETRE UTILISES AVEC AVANTAGE COMME REACTIFS DANS LES PROCEDES IMMUNOCHIMIQUES.
FR7836231A 1977-12-28 1978-12-22 Produits biochimiques insolubilises et stabilises et leur application en tant que reactifs immunochimiques Granted FR2413400A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2758507A DE2758507C3 (de) 1977-12-28 1977-12-28 Stabilisierte biochemische Präparate, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (2)

Publication Number Publication Date
FR2413400A1 true FR2413400A1 (fr) 1979-07-27
FR2413400B1 FR2413400B1 (fr) 1983-05-20

Family

ID=6027537

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7836231A Granted FR2413400A1 (fr) 1977-12-28 1978-12-22 Produits biochimiques insolubilises et stabilises et leur application en tant que reactifs immunochimiques

Country Status (14)

Country Link
US (1) US4273865A (fr)
JP (1) JPS606360B2 (fr)
AT (1) AT366913B (fr)
BE (1) BE872879A (fr)
CA (1) CA1107208A (fr)
DD (1) DD140921A5 (fr)
DE (1) DE2758507C3 (fr)
DK (1) DK581578A (fr)
FR (1) FR2413400A1 (fr)
GB (1) GB2011424B (fr)
IT (1) IT1101738B (fr)
NL (1) NL7812320A (fr)
SE (1) SE444174B (fr)
YU (1) YU309978A (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2459479B1 (fr) * 1979-06-21 1983-07-08 Inst Nat Sante Rech Med Procede de separation d'une substance proteinique a partir d'une solution la contenant par filtration d'affinite et application dudit procede aux dosages enzymatiques
EP0069869B1 (fr) * 1981-07-10 1985-09-11 Gambro Lundia AB Membrane et dispositif de purification d'une solution
DE3223101A1 (de) * 1982-06-21 1983-12-22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Stabilisierte biochemische suspensionspraeparate
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4698302A (en) * 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
GB8314523D0 (en) * 1983-05-25 1983-06-29 Lowe C R Diagnostic device
US4863729A (en) * 1984-06-20 1989-09-05 Linus Pauling Institute Of Science And Medicine Method for preparing a macromolecular monoclonal antibody composition
JPS61232795A (ja) * 1985-04-05 1986-10-17 Clarion Co Ltd ステレオ音受聴装置
DE3518880A1 (de) * 1985-05-25 1986-11-27 Degussa Ag, 6000 Frankfurt Funktionalisierte phenylengruppen-haltige organopolysiloxane und verfahren zu ihrer herstellung
US4689309A (en) * 1985-09-30 1987-08-25 Miles Laboratories, Inc. Test device, method of manufacturing same and method of determining a component in a sample
DD256721A1 (de) * 1986-01-29 1988-05-18 Akad Wissenschaften Ddr Verfahren zur aktivierung von zellulosehaltigen festkoerperoberflaechen
US4789601A (en) * 1987-05-04 1988-12-06 Banes Albert J Biocompatible polyorganosiloxane composition for cell culture apparatus
US4950031A (en) * 1987-07-04 1990-08-21 Mazda Motor Corporation Automobile rear underbody structure
GB8816111D0 (en) * 1988-07-06 1988-08-10 Kodak Ltd Separation of elements defining fluid flow path
IL93134A (en) * 1990-01-23 1997-11-20 Yissum Res Dev Co Doped sol-gel glasses for obtaining chemical interactions
AU7484796A (en) * 1995-11-27 1997-06-19 W.R. Grace & Co.-Conn. Organically modified inorganic oxides using silane-modified inorganic oxides
JP2862509B2 (ja) * 1996-05-28 1999-03-03 東洋電化工業株式会社 リパーゼ固定化用担体及び固定化リパーゼ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3519538A (en) * 1968-09-05 1970-07-07 Corning Glass Works Chemically coupled enzymes
US3715278A (en) * 1970-02-11 1973-02-06 Monsanto Co Enzyme-polymer product attached to surface of siliceous materials thereof
FR2267992A1 (fr) * 1974-04-19 1975-11-14 Rhone Poulenc Ind
DE2619571A1 (de) * 1976-05-04 1977-11-17 Dynamit Nobel Ag Verfahren zum fixieren loeslicher acylasen an anorganisches traegermaterial

Also Published As

Publication number Publication date
DE2758507C3 (de) 1981-05-27
BE872879A (fr) 1979-04-17
YU309978A (en) 1983-10-31
JPS606360B2 (ja) 1985-02-18
AT366913B (de) 1982-05-25
GB2011424A (en) 1979-07-11
GB2011424B (en) 1982-04-07
CA1107208A (fr) 1981-08-18
DE2758507A1 (de) 1979-07-05
ATA882278A (de) 1981-10-15
IT7830880A0 (it) 1978-12-15
DK581578A (da) 1979-06-29
SE444174B (sv) 1986-03-24
DD140921A5 (de) 1980-04-02
SE7813017L (sv) 1979-06-29
DE2758507B2 (de) 1980-07-17
IT1101738B (it) 1985-10-07
US4273865A (en) 1981-06-16
JPS559792A (en) 1980-01-23
NL7812320A (nl) 1979-07-02
FR2413400B1 (fr) 1983-05-20

Similar Documents

Publication Publication Date Title
FR2413400A1 (fr) Produits biochimiques insolubilises et stabilises et leur application en tant que reactifs immunochimiques
US3654090A (en) Method for the determination of antigens and antibodies
ES8606663A1 (es) Un procedimiento de ensayo inmunometrico para detectar la presencia de al menos dos antigenos en una muestra
SE7702465L (sv) Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
NO992167L (no) Preparater og fremgangsmÕter for immobilisering av nukleinsyrer til faste bµrere
ES2053532T3 (es) Metodos de inmunoensayo.
FR2437213A1 (fr) Produits cytotoxiques formes par liaison covalente de la chaine a de la ricine avec un anticorps et leur procede de preparation
FR2415810A1 (fr) Proteines insolubilisees et determinations immunologiques les utilisant
ATE161289T1 (de) Repamycinbestimmung
DE69132238T2 (de) Verfahren zur Stabilisierung von Enzym-Konjugaten
ATE74662T1 (de) Immunoanalysetestverfahren fuer cholesterolepoxide.
PT85317A (fr) Procede pour l:obtention d:imunotoxines par couplage d:un anticorps avec une proteine trichosanthine ou trickokirine
EP0096463B1 (fr) Demi-molécules d'immunoglobulines et procédé de production d'anticorps hybrides
GB1549069A (en) Enzyme linked immunoassay
ATE44621T1 (de) Proteinkonjugate von penicillosaeure, ihre herstellung und verwendung.
FR2389136A1 (fr) Procede de dosage global d'hormones et de produits pharmaceutiques
DE3851221T2 (de) Nichttrennender festphasen-enzymtest.
FR2422687A1 (fr) Conjugue de sucre amine et d'hormone steroide
DE3273844D1 (en) Procedure for immunological determinations using two antibodies, the second antibody being purified by affinity chromatography, and supports therefor
ATE4327T1 (de) Verfahren zur gewinnung von immunologisch aktiven enzymmarkierten konjugaten.
FR2432713A1 (fr) Application de la d5,3-ceto steroide isomerase dans les dosages immunoenzymatiques
AU539531B2 (en) Immunochemical assay for prostatic acid phosphatase
ES8606500A1 (es) Un metodo para determinar la presencia de ige especifica en sueros humanos
DE3778259D1 (de) Verfahren zur differenzial-bestimmung von amylase-isoenzymen und satz dafuer.
DE3461566D1 (en) Heterogeneous assay method for antigenic biological substances using antibody-hybrid conjugates, and reagent therefor

Legal Events

Date Code Title Description
ST Notification of lapse