DK0469520T3 - Fremgangsmåde til fremstilling af rent polylactid - Google Patents

Fremgangsmåde til fremstilling af rent polylactid

Info

Publication number
DK0469520T3
DK0469520T3 DK91112725T DK91112725T DK0469520T3 DK 0469520 T3 DK0469520 T3 DK 0469520T3 DK 91112725 T DK91112725 T DK 91112725T DK 91112725 T DK91112725 T DK 91112725T DK 0469520 T3 DK0469520 T3 DK 0469520T3
Authority
DK
Denmark
Prior art keywords
preparation
pure polylactide
polylactide
pure
Prior art date
Application number
DK91112725T
Other languages
Danish (da)
English (en)
Inventor
Walter Prikoszovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0469520T3 publication Critical patent/DK0469520T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK91112725T 1990-08-01 1991-07-29 Fremgangsmåde til fremstilling af rent polylactid DK0469520T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
DK0469520T3 true DK0469520T3 (da) 1998-09-23

Family

ID=26297417

Family Applications (2)

Application Number Title Priority Date Filing Date
DK91112725T DK0469520T3 (da) 1990-08-01 1991-07-29 Fremgangsmåde til fremstilling af rent polylactid
DK97202586T DK0816413T3 (da) 1990-08-01 1991-07-29 Farmaceutisk præparat indeholdende rent polylactid og et hydrofilt eller lipofilt lægemiddel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK97202586T DK0816413T3 (da) 1990-08-01 1991-07-29 Farmaceutisk præparat indeholdende rent polylactid og et hydrofilt eller lipofilt lægemiddel

Country Status (27)

Country Link
EP (2) EP0816413B1 (fi)
JP (1) JP3137368B2 (fi)
KR (1) KR100255904B1 (fi)
AT (1) AT402503B (fi)
AU (1) AU650277B2 (fi)
CA (1) CA2048200C (fi)
CH (1) CH683772A5 (fi)
CY (1) CY1986A (fi)
DE (1) DE4124468B4 (fi)
DK (2) DK0469520T3 (fi)
ES (2) ES2112259T3 (fi)
FI (2) FI108040B (fi)
FR (1) FR2665453B1 (fi)
GB (1) GB2246573B (fi)
GR (1) GR3026322T3 (fi)
HK (1) HK11797A (fi)
HU (1) HUT59837A (fi)
IE (1) IE66185B1 (fi)
IL (1) IL99007A (fi)
IT (1) IT1252944B (fi)
LU (1) LU87985A1 (fi)
MY (1) MY108621A (fi)
NO (1) NO912960D0 (fi)
NZ (1) NZ239184A (fi)
PH (1) PH31047A (fi)
PT (1) PT98491B (fi)
TW (2) TW282477B (fi)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
SK282231B6 (sk) * 1993-11-19 2001-12-03 Janssen Pharmaceutica N. V. Farmaceutický prostriedok na liečenie psychotických porúch
KR100357839B1 (ko) * 1994-03-07 2003-08-02 더 다우 케미칼 캄파니 생체활성및/또는표적화된덴드리머콘쥬게이트
DK1112095T3 (da) 1998-09-11 2003-03-17 Michael Dr Raschke Biologisk aktive implantater
US6362308B1 (en) 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
DE60225445T2 (de) * 2001-07-10 2009-03-26 Kureha Corp. Polyhydroxycarbonsäure und verfahren zu dessen herstellung
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
MXPA04003433A (es) * 2001-10-10 2004-08-11 Pf Medicament Microesferas biodegradables de liberacion prolongada y metodo para preparar las mismas.
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
EP1787658B1 (en) 2005-11-10 2012-03-14 CHEMI S.p.A. Sustained release formulations of somatostatin analogue inhibitors of growth hormone
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
CN101910246B (zh) * 2007-12-31 2013-01-02 株式会社三养生物制药 包含源自α-羟酸的疏水嵌段的高纯两亲共聚物及其制备方法
WO2010111238A2 (en) * 2009-03-23 2010-09-30 Micell Technologies, Inc. Improved biodegradable polymers
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
KR101130825B1 (ko) * 2010-06-21 2012-03-28 주식회사 엘지화학 내열성이 우수한 폴리락타이드 수지 및 이의 제조방법
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
US10556999B2 (en) 2016-01-29 2020-02-11 Tolmar, Inc. Purification and decolorization of polymers
SG11202001688WA (en) * 2017-08-31 2020-03-30 Evonik Corp Improved resorbable polymer purification process
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
US4677231A (en) * 1984-11-13 1987-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of polyether
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
DE69129770T2 (de) * 1990-04-13 1998-11-19 Takeda Chemical Industries Ltd Biologisch abbaubare hochmolekulare Polymere, ihre Herstellung und ihre Verwendung

Also Published As

Publication number Publication date
DE4124468B4 (de) 2010-10-28
CH683772A5 (de) 1994-05-13
DK0816413T3 (da) 2005-08-29
FI108040B (fi) 2001-11-15
GR3026322T3 (en) 1998-06-30
FI111268B (fi) 2003-06-30
PT98491A (pt) 1992-06-30
ES2112259T3 (es) 1998-04-01
HK11797A (en) 1997-02-14
IE66185B1 (en) 1995-12-13
FI913641A (fi) 1992-02-02
FR2665453B1 (fr) 1995-01-27
TW218025B (fi) 1993-12-21
CA2048200A1 (en) 1992-02-02
IT1252944B (it) 1995-07-05
TW282477B (fi) 1996-08-01
JP3137368B2 (ja) 2001-02-19
AU650277B2 (en) 1994-06-16
KR100255904B1 (ko) 2000-05-01
GB9116396D0 (en) 1991-09-11
EP0469520A2 (en) 1992-02-05
ITRM910553A0 (it) 1991-07-23
GB2246573B (en) 1994-05-11
FR2665453A1 (fr) 1992-02-07
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
EP0469520A3 (en) 1992-10-07
IL99007A0 (en) 1992-07-15
AT402503B (de) 1997-06-25
FI913641A0 (fi) 1991-07-30
CY1986A (en) 1997-09-05
ATA151591A (de) 1996-10-15
EP0816413B1 (en) 2005-06-08
GB2246573A (en) 1992-02-05
LU87985A1 (fr) 1993-02-15
DE4124468A1 (de) 1992-02-06
HUT59837A (en) 1992-07-28
EP0469520B1 (en) 1998-02-25
EP0816413A2 (en) 1998-01-07
PT98491B (pt) 1997-12-31
MY108621A (en) 1996-10-31
PH31047A (en) 1998-02-03
NO912960D0 (no) 1991-07-30
AU8143091A (en) 1992-02-27
CA2048200C (en) 1999-06-29
ITRM910553A1 (it) 1993-01-23
IE912697A1 (en) 1992-02-12
IL99007A (en) 1994-12-29
JPH0641279A (ja) 1994-02-15
FI20011189A (fi) 2001-06-05
NZ239184A (en) 1994-09-27
KR920003990A (ko) 1992-03-27
HU912452D0 (en) 1991-12-30

Similar Documents

Publication Publication Date Title
DK0469520T3 (da) Fremgangsmåde til fremstilling af rent polylactid
DK0518874T3 (da) Fremgangsmåde til fremstilling af tagatose
DK0454386T3 (da) Fremgangsmåde til fremstilling af saccharose-6-ester
DK0506139T3 (da) Fremgangsmåde til fremstilling af organiske gødningsstoffer
IS3369A7 (is) Aðferð til framleiðslu efnasambanda sem afleidd eru af benzopyran
DK0670835T3 (da) Fremgangsmåde til fremstilling af benzopyranforbindelser
DK0523829T3 (da) Fremgangsmåde til syntese af betazeolit
DK0395144T3 (da) Fremgangsmåde til fremtilling af aromatiske urinstoffer
DK0451094T3 (da) Fremgangsmåde til fremstilling af pigmenter
DK0535900T3 (da) Ettrinsfremgangsmåde til fremstilling af dirithromycin
DK0538303T3 (da) Fremgangsmåde til fremstilling af cycliske sulfater
DK0417680T3 (da) Fremgangsmåde til fremstilling af 1,1,1,2-tetrafluorethan
DK0499157T3 (da) Fremgangsmåde til fremstilling af 1,3-dioxoler
DK0407961T3 (da) Fremgangsmåde til fremstilling af 1,1,1-trifluor-2-chlorethan
DK0483927T3 (da) Fremgangsmåde til fremstilling af krystallinsk aluminiumphosphat
DK0648738T3 (da) Fremgangsmåde til fremstilling af acetoacetarylamider
DK0465373T3 (da) Fremgangsmåde til fremstilling af kappa-carragenaner
DK0648748T3 (da) Fremgangsmåde til fremstilling af 5-acetoacetylaminobenzimidazolon-2
NO942218D0 (no) Fremgangsmåte for fremstilling av karbonatsammensetning
DK0519512T3 (da) Mikrobiologisk fremgangsmåde til fremstilling af 5-hydroxypyrazincarboxylsyre
DK0388620T3 (da) Fremgangsmåde til fremstilling af o-carboxy-pyridyl- og o-carboxyquinolylimidazolinoner
DK153592A (da) Fremgangsmåde til fremstilling af 2,3,5,6-tetrachlorpyridin
DK0409321T3 (da) Fremgangsmåde til fremstilling af delta-lactoner
DK56694A (da) Fremgangsmåde til fremstilling af cephemderivater
DK0427287T3 (da) Fremgangsmåde til fremstilling af indoler