DK0436355T3 - Fremgangsmåde til fremstilling af 7-aminocephemforbindelse eller salte deraf - Google Patents

Fremgangsmåde til fremstilling af 7-aminocephemforbindelse eller salte deraf

Info

Publication number
DK0436355T3
DK0436355T3 DK90313988.9T DK90313988T DK0436355T3 DK 0436355 T3 DK0436355 T3 DK 0436355T3 DK 90313988 T DK90313988 T DK 90313988T DK 0436355 T3 DK0436355 T3 DK 0436355T3
Authority
DK
Denmark
Prior art keywords
compound
aminocephem
producing
cooh
acremonium chrysogenum
Prior art date
Application number
DK90313988.9T
Other languages
Danish (da)
English (en)
Inventor
Takao Isogai
Masao Fukagawa
Morita Iwami
Ichiro Aramori
Hitoshi Kojo
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Application granted granted Critical
Publication of DK0436355T3 publication Critical patent/DK0436355T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0022—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12N9/0024—D-Amino acid oxidase (1.4.3.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK90313988.9T 1989-12-27 1990-12-20 Fremgangsmåde til fremstilling af 7-aminocephemforbindelse eller salte deraf DK0436355T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34211389 1989-12-27
JP19360990 1990-07-20

Publications (1)

Publication Number Publication Date
DK0436355T3 true DK0436355T3 (da) 1996-05-28

Family

ID=26507976

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90313988.9T DK0436355T3 (da) 1989-12-27 1990-12-20 Fremgangsmåde til fremstilling af 7-aminocephemforbindelse eller salte deraf

Country Status (13)

Country Link
US (1) US5677141A (hu)
EP (1) EP0436355B1 (hu)
JP (3) JP3057759B2 (hu)
KR (1) KR0171897B1 (hu)
AT (1) ATE137803T1 (hu)
CA (1) CA2032963C (hu)
DE (1) DE69026921T2 (hu)
DK (1) DK0436355T3 (hu)
ES (1) ES2086386T3 (hu)
GR (1) GR3020071T3 (hu)
HU (1) HU212767B (hu)
IE (1) IE75376B1 (hu)
TR (1) TR27317A (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019724D0 (en) * 1990-09-10 1990-10-24 Fujisawa Pharmaceutical Co Cephalosporin c acylase
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정
CA2100987C (en) * 1992-07-27 1999-06-15 Kaoru Furuya A transformant capable of producing d-amino acid oxidase
CN1515679A (zh) * 1997-09-09 2004-07-28 ���������ﻯѧ���޹�˾ 不含酯酶的酶
US6410323B1 (en) * 1999-08-31 2002-06-25 Isis Pharmaceuticals, Inc. Antisense modulation of human Rho family gene expression
CN1531539A (zh) 2001-04-19 2004-09-22 ��ŷ�����¶����ǹɷ����޹�˾ 用α-酮酸衍生物制备头孢烷酸衍生物的酶促方法
DE10153792A1 (de) * 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
ATE302283T1 (de) * 2002-10-31 2005-09-15 Bioferma Murcia S A Einfaches enzymatisches verfahren zur herstellung von cefazolin
KR100530299B1 (ko) * 2003-08-11 2005-11-22 산도즈 게엠베하 변이 세팔로스포린 ｃ 아실라제 및 이를 이용한 7-ａｃａ 제조방법
ITMI20040016A1 (it) * 2004-01-12 2004-04-12 Antibiotics S P A Cefalosporina c acilasi
US7981090B2 (en) 2006-10-18 2011-07-19 Baxter International Inc. Luer activated device
US8221363B2 (en) 2006-10-18 2012-07-17 Baxter Healthcare S.A. Luer activated device with valve element under tension
US7753338B2 (en) 2006-10-23 2010-07-13 Baxter International Inc. Luer activated device with minimal fluid displacement

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52143289A (en) * 1976-05-24 1977-11-29 Meiji Seika Kaisha Ltd Production of 7-amino-cephem derivatives by filamentous fungi
US4925794A (en) * 1985-01-02 1990-05-15 Fujisawa Pharmaceutical Co., Ltd. Hybrid plasmids and microorganisms containing them
US5208155A (en) * 1985-01-11 1993-05-04 Klaus Mosbach D-amino acid oxidase and method for isolation thereof
EP0200425B1 (en) * 1985-04-22 1991-12-27 Eli Lilly And Company Recombinant dna expression vectors and dna compounds
JPH0829114B2 (ja) * 1986-09-18 1996-03-27 旭化成工業株式会社 ７−アミノセフアロスポラン酸およびその誘導体の製造法
EP0322032A3 (en) * 1987-12-21 1991-01-30 Merck & Co. Inc. One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives
ES2020792A6 (es) * 1990-08-03 1991-09-16 Antibioticos Sa Un procedimiento enzimatico para la presentacion de acido 7-amino-cefa-losporanico y un procedimiento para expresar la enzima 7b (4-carboxibutanamido) cefalosporinacilasa.
IT1252308B (it) * 1990-12-21 1995-06-08 Antibioticos Spa Procedimento enzimatico per la produzione di acido 7- amminocefalosporanico e derivati
KR100227711B1 (ko) * 1991-10-15 1999-12-01 한스 발터 라벤 7-아미노세팔로스포란산 및 7-아미노데아세틸세팔로스포란산 제조를 위한 신규한 생물학적 공정

Also Published As

Publication number Publication date
JP3057759B2 (ja) 2000-07-04
JP3239359B2 (ja) 2001-12-17
JP2000152796A (ja) 2000-06-06
ATE137803T1 (de) 1996-05-15
HU908442D0 (en) 1991-07-29
KR0171897B1 (ko) 1999-02-01
JPH04234994A (ja) 1992-08-24
HUT58368A (en) 1992-02-28
EP0436355A3 (en) 1991-10-09
DE69026921D1 (de) 1996-06-13
IE75376B1 (en) 1997-09-10
EP0436355A2 (en) 1991-07-10
KR910012261A (ko) 1991-07-30
GR3020071T3 (en) 1996-08-31
CA2032963C (en) 2002-02-19
DE69026921T2 (de) 1996-11-14
TR27317A (tr) 1995-01-12
ES2086386T3 (es) 1996-07-01
JP2001186894A (ja) 2001-07-10
EP0436355B1 (en) 1996-05-08
CA2032963A1 (en) 1991-06-28
IE904640A1 (en) 1991-07-17
US5677141A (en) 1997-10-14
HU212767B (en) 1996-11-28

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