DK0387867T3 - Præparat indeholdende D-cycloserin og D-alanin til forbedring af hukommelse og indlæringsevne eller til behandling af en kognitiv eller psykotisk lidelse - Google Patents
Præparat indeholdende D-cycloserin og D-alanin til forbedring af hukommelse og indlæringsevne eller til behandling af en kognitiv eller psykotisk lidelseInfo
- Publication number
- DK0387867T3 DK0387867T3 DK90104875.1T DK90104875T DK0387867T3 DK 0387867 T3 DK0387867 T3 DK 0387867T3 DK 90104875 T DK90104875 T DK 90104875T DK 0387867 T3 DK0387867 T3 DK 0387867T3
- Authority
- DK
- Denmark
- Prior art keywords
- cycloserine
- alanine
- cognitive
- treat
- psychotic disorder
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Macromonomer-Based Addition Polymer (AREA)
- Detergent Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32427989A | 1989-03-15 | 1989-03-15 | |
| US07/473,241 US5061721A (en) | 1989-03-15 | 1990-02-06 | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0387867T3 true DK0387867T3 (da) | 1993-06-01 |
Family
ID=26984373
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90104875.1T DK0387867T3 (da) | 1989-03-15 | 1990-03-15 | Præparat indeholdende D-cycloserin og D-alanin til forbedring af hukommelse og indlæringsevne eller til behandling af en kognitiv eller psykotisk lidelse |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5061721A (cs) |
| EP (1) | EP0387867B1 (cs) |
| JP (1) | JP2963720B2 (cs) |
| KR (1) | KR900013961A (cs) |
| AT (1) | ATE88890T1 (cs) |
| AU (1) | AU624917B2 (cs) |
| CA (1) | CA2010635C (cs) |
| DE (1) | DE69001503T2 (cs) |
| DK (1) | DK0387867T3 (cs) |
| ES (1) | ES2055197T3 (cs) |
| FI (1) | FI901289A7 (cs) |
| GR (1) | GR3008225T3 (cs) |
| IE (1) | IE64130B1 (cs) |
| IL (1) | IL93562A (cs) |
| NO (1) | NO901198L (cs) |
| NZ (1) | NZ232809A (cs) |
| PT (1) | PT93424B (cs) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5153193A (en) * | 1991-10-01 | 1992-10-06 | Hoechst-Roussel Pharmaceuticals Incorporated | Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs |
| US5854217A (en) | 1992-09-28 | 1998-12-29 | Bearsden Bio, Inc. | Allosteric modulators of the NMDA receptor and their use in the treatment of CNS disorders and enhancement of CNS function |
| JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
| US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US20040208875A1 (en) | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
| ES2251935T3 (es) * | 1993-03-29 | 2006-05-16 | Queen's University At Kingston | Acido propan-1,3-disulfonico y sus sales farmaceuticamente aceptables para el tratamiento de amiloidosis. |
| US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
| WO1996015788A1 (en) * | 1994-11-23 | 1996-05-30 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
| ATE204852T1 (de) * | 1995-02-15 | 2001-09-15 | Bearsden Bio Inc | Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor |
| US6277825B1 (en) | 1996-07-22 | 2001-08-21 | University Of Utah Research Foundation | Use of conantokins for treating pain |
| AU727196B2 (en) | 1996-07-22 | 2000-12-07 | Cognetix, Inc. | Conantokins |
| CA2261570A1 (en) | 1996-07-22 | 1998-01-29 | Cognetix, Inc. | Use of conantokins |
| WO1999052519A2 (en) * | 1998-04-14 | 1999-10-21 | The General Hospital Corporation | Methods for treating neuropsychiatric disorders |
| US6551993B1 (en) * | 1999-08-16 | 2003-04-22 | Thomas Jefferson University | Partial agonists at the glycine modulatory site of the NMDA receptor for treating cognitive dysfunction |
| US6399574B1 (en) | 2000-03-22 | 2002-06-04 | University Of Utah Research Foundation | Use of conantokins |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| US20050096396A1 (en) * | 2002-03-28 | 2005-05-05 | Emory University | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| US7846913B2 (en) | 2003-12-29 | 2010-12-07 | Mcdevitt Jason Patrick | Compositions and methods to treat recurrent medical conditions |
| US7750030B2 (en) * | 2001-03-29 | 2010-07-06 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
| CN1527813A (zh) * | 2001-04-02 | 2004-09-08 | О | 作为治疗剂的抗氧化剂硝基氧和亚硝氮碳基 |
| ES2314056T3 (es) * | 2001-05-02 | 2009-03-16 | Blanchette Rockefeller Neurosciences Institute | Activadores de la anhidrasa carbonica para mejorar el aprendizaje y la memoria. |
| CA2478808A1 (en) * | 2002-03-15 | 2003-09-25 | H. Lundbeck A/S | Use of asc-1 inhibitors to treat neurological and psychiatric disorders |
| EP2260844A1 (en) * | 2003-05-27 | 2010-12-15 | Merz Pharma GmbH & Co. KGaA | Combination of an NMDA Receptor Antagonist and a Selective Serotonin Reuptake Inhibitor for the Treatment of Depression and other Mood Disorders |
| US20070010573A1 (en) | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| US7414076B2 (en) | 2003-06-23 | 2008-08-19 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| EP1660634A4 (en) * | 2003-08-08 | 2009-02-18 | Burnham Inst | P16-mediated regulation of NMDA receptors |
| TW201207390A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| CN101128421A (zh) | 2004-12-22 | 2008-02-20 | 神经化学(国际)有限公司 | 治疗淀粉样相关疾病用的方法与组合物 |
| MX2007012374A (es) | 2005-04-06 | 2008-02-22 | Adamas Pharmaceuticals Inc | Metodos y composiciones para el tratamiento de condiciones relacionadas con cns. |
| TW200716088A (en) | 2005-04-15 | 2007-05-01 | Neurochem Int Ltd | Formulations and methods for treating amyloidosis |
| KR101443573B1 (ko) | 2006-10-12 | 2014-11-03 | 비에이치아이 리미티드 파트너쉽 | 3-아미노-1-프로판설폰산을 전달하기 위한 방법, 화합물, 조성물 및 비히클 |
| US20100113453A1 (en) * | 2007-04-10 | 2010-05-06 | Mcdevitt Jason P | Sublingual Formulations of D-Cycloserine and Methods of Using Same |
| CN102186883B (zh) | 2008-09-18 | 2016-08-03 | 西北大学 | Nmda受体调节剂和其用途 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
| TWI544923B (zh) * | 2009-12-29 | 2016-08-11 | 何應瑞 | 用於治療神經退化性疾病之醫藥組合物 |
| SG183265A1 (en) | 2010-02-11 | 2012-09-27 | Univ Northwestern | Secondary structure stabilized nmda receptor modulators and uses thereof |
| KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
| JP5689026B2 (ja) * | 2010-06-17 | 2015-03-25 | 株式会社 資生堂 | 水中油型乳化皮膚化粧料 |
| ES2673956T3 (es) | 2011-01-31 | 2018-06-26 | Serotech, Llc | Régimen de dosificación, envase de dispensación de la medicación y usos de los mismos para el tratamiento del trastorno depresivo mayor |
| PT2931291T (pt) | 2012-12-11 | 2021-12-03 | Mclean Hospital Corp | Tratamento com xénon como complemento da psicoterapia para perturbações psiquiátricas |
| CN105229011B (zh) | 2013-01-29 | 2018-02-06 | 阿普廷伊克斯股份有限公司 | 螺‑内酰胺nmda受体调节剂及其用途 |
| MX375286B (es) | 2013-01-29 | 2025-03-06 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
| CA2898863A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| PE20151438A1 (es) | 2013-01-29 | 2015-10-10 | Naurex Inc | Moduladores de receptores nmda de espiro-lactama y sus usos |
| ES2618421T3 (es) | 2013-01-29 | 2017-06-21 | Aptinyx Inc. | Moduladores espiro-lactama del receptor NMDA y usos de los mismos |
| US9877951B2 (en) | 2015-02-12 | 2018-01-30 | College Of William And Mary | Method for treating dementia |
| CA3024606C (en) | 2016-05-19 | 2019-09-03 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| WO2018026782A1 (en) | 2016-08-01 | 2018-02-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
| JP2019527232A (ja) | 2016-08-01 | 2019-09-26 | アプティニックス インコーポレイテッド | スピロ−ラクタムnmda修飾因子及びこれを用いた方法 |
| US11028095B2 (en) | 2016-08-01 | 2021-06-08 | Aptinyx Inc. | Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof |
| JP7036792B2 (ja) | 2016-08-01 | 2022-03-15 | アプティニックス インコーポレイテッド | スピロ-ラクタムnmda受容体修飾因子およびその使用 |
| US11299495B2 (en) | 2016-08-01 | 2022-04-12 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| EP3427729A1 (en) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid for use in treating epileptic diseases, disorders or conditions |
| US11578072B2 (en) | 2018-01-31 | 2023-02-14 | Aptinyx Inc. | Spiro-lactam NMDA receptor modulators and uses thereof |
| WO2020252384A1 (en) * | 2019-06-14 | 2020-12-17 | Vorsanger Gary | Treatment methods utilizing oxytocin receptor agonists |
| US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
| CA3154457C (en) | 2019-11-27 | 2024-06-25 | Neurorive Inc | Combination therapy of cycloserine and lithium for the treatment of depression |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3428730A (en) * | 1967-06-30 | 1969-02-18 | Hamao Umezawa | Antibacterial mixture of o-carbamyl-d-serine and d-4-amino-3-isoxazolidone |
| US4031231A (en) * | 1974-06-13 | 1977-06-21 | Merck & Co., Inc. | Antibacterial composition comprising 3-fluoro-D-alanine or deutero analog in combination with auto-antagonist inhibitor |
| US4904681A (en) * | 1987-12-01 | 1990-02-27 | G. D. Searle & Co. | D-cycloserine and its prodrugs as cognitive enhancers |
-
1990
- 1990-02-06 US US07/473,241 patent/US5061721A/en not_active Expired - Lifetime
- 1990-02-27 IL IL9356290A patent/IL93562A/en active IP Right Grant
- 1990-03-06 AU AU50734/90A patent/AU624917B2/en not_active Ceased
- 1990-03-06 NZ NZ232809A patent/NZ232809A/en unknown
- 1990-03-14 JP JP2063937A patent/JP2963720B2/ja not_active Expired - Lifetime
- 1990-03-14 IE IE92190A patent/IE64130B1/en not_active IP Right Cessation
- 1990-03-14 CA CA002010635A patent/CA2010635C/en not_active Expired - Fee Related
- 1990-03-14 PT PT93424A patent/PT93424B/pt not_active IP Right Cessation
- 1990-03-14 NO NO90901198A patent/NO901198L/no unknown
- 1990-03-15 FI FI901289A patent/FI901289A7/fi not_active IP Right Cessation
- 1990-03-15 ES ES90104875T patent/ES2055197T3/es not_active Expired - Lifetime
- 1990-03-15 KR KR1019900003482A patent/KR900013961A/ko not_active Ceased
- 1990-03-15 DE DE9090104875T patent/DE69001503T2/de not_active Expired - Fee Related
- 1990-03-15 AT AT90104875T patent/ATE88890T1/de not_active IP Right Cessation
- 1990-03-15 DK DK90104875.1T patent/DK0387867T3/da active
- 1990-03-15 EP EP90104875A patent/EP0387867B1/en not_active Expired - Lifetime
-
1993
- 1993-06-18 GR GR930400134T patent/GR3008225T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI901289A7 (fi) | 1990-09-16 |
| KR900013961A (ko) | 1990-10-22 |
| NZ232809A (en) | 1992-05-26 |
| AU624917B2 (en) | 1992-06-25 |
| IL93562A (en) | 1996-01-31 |
| IL93562A0 (en) | 1990-11-29 |
| JP2963720B2 (ja) | 1999-10-18 |
| US5061721A (en) | 1991-10-29 |
| IE900921L (en) | 1990-09-15 |
| EP0387867B1 (en) | 1993-05-05 |
| ATE88890T1 (de) | 1993-05-15 |
| NO901198D0 (no) | 1990-03-14 |
| IE64130B1 (en) | 1995-07-12 |
| JPH03148221A (ja) | 1991-06-25 |
| CA2010635A1 (en) | 1990-09-15 |
| DE69001503T2 (de) | 1993-09-09 |
| AU5073490A (en) | 1990-09-20 |
| FI901289A0 (fi) | 1990-03-15 |
| DE69001503D1 (de) | 1993-06-09 |
| PT93424A (pt) | 1990-11-07 |
| EP0387867A1 (en) | 1990-09-19 |
| ES2055197T3 (es) | 1994-08-16 |
| CA2010635C (en) | 2001-03-06 |
| GR3008225T3 (cs) | 1993-09-30 |
| PT93424B (pt) | 1996-08-30 |
| NO901198L (no) | 1990-09-17 |
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