DK0380331T3 - Anvendelse af di-tert.butylhydroxyphenylthioderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af arteriosklerose eller atherosklerose - Google Patents
Anvendelse af di-tert.butylhydroxyphenylthioderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af arteriosklerose eller atheroskleroseInfo
- Publication number
- DK0380331T3 DK0380331T3 DK90300764.9T DK90300764T DK0380331T3 DK 0380331 T3 DK0380331 T3 DK 0380331T3 DK 90300764 T DK90300764 T DK 90300764T DK 0380331 T3 DK0380331 T3 DK 0380331T3
- Authority
- DK
- Denmark
- Prior art keywords
- atherosclerosis
- tert
- derivatives
- butylhydroxyphenylthio
- medicament
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
- C07C321/22—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1015387A JP2627003B2 (ja) | 1989-01-25 | 1989-01-25 | ジーtert―ブチルヒドロキシフェニルチオ誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0380331T3 true DK0380331T3 (da) | 1994-02-14 |
Family
ID=11887332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90300764.9T DK0380331T3 (da) | 1989-01-25 | 1990-01-24 | Anvendelse af di-tert.butylhydroxyphenylthioderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af arteriosklerose eller atherosklerose |
Country Status (7)
Country | Link |
---|---|
US (1) | US4954514A (ja) |
EP (1) | EP0380331B1 (ja) |
JP (1) | JP2627003B2 (ja) |
KR (1) | KR900011754A (ja) |
AT (1) | ATE98227T1 (ja) |
DE (1) | DE69004984T2 (ja) |
DK (1) | DK0380331T3 (ja) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5071876A (en) * | 1985-02-04 | 1991-12-10 | G. D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
US5192791A (en) * | 1988-09-26 | 1993-03-09 | Biofor, Ltd. | Fused ring heterocycles and pharmaceutical compositions containing same |
WO1994001433A1 (en) * | 1992-07-13 | 1994-01-20 | Japan Tobacco Inc. | Novel thiazolidinedione compound and use thereof |
US5326907A (en) * | 1992-12-18 | 1994-07-05 | G. D. Searle & Co. | 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers |
AU5337498A (en) * | 1997-01-22 | 1998-08-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted beta-thiocarboxylic acids |
US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
CN1275596C (zh) | 1997-05-14 | 2006-09-20 | 阿特罗吉尼克斯公司 | 普罗布考单酯在制备用于治疗心血管疾病和炎性疾病的药物中的应用 |
US6852878B2 (en) * | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
CN1261803A (zh) * | 1997-07-01 | 2000-08-02 | 埃瑟若詹尼克斯公司 | 抗氧化剂增强对细胞过度增生性疾病的治疗 |
EP1127882A1 (en) | 2000-01-25 | 2001-08-29 | Pfizer Products Inc. | Tetrazole compounds as thyroid receptor ligands |
AU2002320025A1 (en) * | 2001-04-11 | 2002-11-11 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
CN100415227C (zh) * | 2001-10-25 | 2008-09-03 | 阿特罗吉尼克斯公司 | 化合物在制备用于治疗移植排斥的药物中的应用 |
KR20050044352A (ko) * | 2001-11-09 | 2005-05-12 | 아테로제닉스, 인코포레이티드 | 심혈관 병리의 역전 및 예방 방법 |
JP4467429B2 (ja) * | 2002-07-12 | 2010-05-26 | アセロジエニクス・インコーポレイテツド | 低溶解性プロブコールエステル類およびエーテル類の新規な塩形態 |
US20040110803A1 (en) * | 2002-09-13 | 2004-06-10 | Hossein Dovlatabadi | Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels |
WO2005112914A2 (en) | 2004-04-20 | 2005-12-01 | Atherogenics, Inc. | Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease |
WO2005102323A2 (en) | 2004-04-20 | 2005-11-03 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
JP2010522762A (ja) | 2007-03-26 | 2010-07-08 | サルトリア・フアーマシユーテイカルズ・エル・エル・シー | 糖尿病の治療のための方法及びプロブコール誘導体の組成物 |
WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
WO2008130718A1 (en) | 2007-04-23 | 2008-10-30 | Atherogenics, Inc. | Sulfonamide containing compounds for treatment of inflammatory disorders |
CN103896815B (zh) * | 2014-03-26 | 2016-03-30 | 安徽师范大学 | 一种邻位巯基苯酚衍生物及其制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3337576A (en) * | 1966-01-20 | 1967-08-22 | Bristol Myers Co | Arylthioalkyltetrazoles |
DE1936463A1 (de) * | 1969-07-17 | 1971-02-04 | Boehringer Sohn Ingelheim | Substituierte Phenole |
CA1037964A (en) * | 1973-02-14 | 1978-09-05 | Eugene R. Wagner | 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters |
US4029812A (en) * | 1976-02-18 | 1977-06-14 | The Dow Chemical Company | Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides |
EP0190682B1 (en) * | 1985-02-04 | 1990-09-12 | G.D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
US4755524A (en) * | 1986-01-31 | 1988-07-05 | G. D. Searle & Co. | Novel phenolic thioethers as inhibitors of 5-lipoxygenase |
-
1989
- 1989-01-25 JP JP1015387A patent/JP2627003B2/ja not_active Expired - Fee Related
- 1989-12-18 US US07/451,743 patent/US4954514A/en not_active Expired - Fee Related
- 1989-12-30 KR KR1019890020496A patent/KR900011754A/ko not_active Application Discontinuation
-
1990
- 1990-01-24 DK DK90300764.9T patent/DK0380331T3/da active
- 1990-01-24 AT AT90300764T patent/ATE98227T1/de not_active IP Right Cessation
- 1990-01-24 DE DE90300764T patent/DE69004984T2/de not_active Expired - Fee Related
- 1990-01-24 EP EP90300764A patent/EP0380331B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR900011754A (ko) | 1990-08-02 |
EP0380331A1 (en) | 1990-08-01 |
EP0380331B1 (en) | 1993-12-08 |
DE69004984T2 (de) | 1994-04-07 |
ATE98227T1 (de) | 1993-12-15 |
JP2627003B2 (ja) | 1997-07-02 |
JPH02196770A (ja) | 1990-08-03 |
DE69004984D1 (de) | 1994-01-20 |
US4954514A (en) | 1990-09-04 |
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