KR900011754A - (디-3급-부틸히드록시페닐)티오 유도체 - Google Patents

(디-3급-부틸히드록시페닐)티오 유도체 Download PDF

Info

Publication number
KR900011754A
KR900011754A KR1019890020496A KR890020496A KR900011754A KR 900011754 A KR900011754 A KR 900011754A KR 1019890020496 A KR1019890020496 A KR 1019890020496A KR 890020496 A KR890020496 A KR 890020496A KR 900011754 A KR900011754 A KR 900011754A
Authority
KR
South Korea
Prior art keywords
cyano
tert
tetrazolyl
carbamoyl
butylhydroxyphenyl
Prior art date
Application number
KR1019890020496A
Other languages
English (en)
Inventor
도루 기따
수우 나루미야
마사유끼 나리사다
후미히꼬 와따나베
마사미 도떼우찌
다꾸지 미즈이
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR900011754A publication Critical patent/KR900011754A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/22—Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

(디-3급-부틸히드록시페닐)티오 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 일반식의 화합물 또는 약제학적으로 허용되는 그들의 염
    [식에서, R은 시아노, 카르바모일 또는 5-테트라졸릴이고;n은 2 내지 6의 상수이고; 단 R이 시아노일 때 n은 2가 아니다:]
  2. 2, 6-디-3급-부틸-4-메르캅토페놀을 알킬화제로 반응하여 임의로 산아미드 형성 또는 테트라졸 형성을 하고 필요하다면: 수득된 화합물을 염형성 시킴을 특징으로 하는 하기 일반식의 화합물 및 약제학적으로 허용되는 그들의 염을 제조하는 방법.
    [식에서 R은 시아노, 카르바모일 또는 5-테트라졸릴이고: n은 2 내지 6의 상수이고; 단 R이 시아노일 때 n은 2가 아니다:]
  3. 하기 일반식의 적어도 한 화합물 또는 약제학적으로 허용되는 그들의 염을 약물학적 유효량 함유하는 포유 동물의 동맥경화증 치료의 용도에 대한 약물학적 조성물.
    [식에서, R은 시아노, 카르바모일, 또는 5-테트라졸릴이고: n은 2 내지 6의 정수이고: 단 R이 시아노일 때 n은 2가 아니다.]
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890020496A 1989-01-25 1989-12-30 (디-3급-부틸히드록시페닐)티오 유도체 KR900011754A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP89-15387 1989-01-25
JP1015387A JP2627003B2 (ja) 1989-01-25 1989-01-25 ジーｔｅｒｔ―ブチルヒドロキシフェニルチオ誘導体

Publications (1)

Publication Number Publication Date
KR900011754A true KR900011754A (ko) 1990-08-02

Family

ID=11887332

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890020496A KR900011754A (ko) 1989-01-25 1989-12-30 (디-3급-부틸히드록시페닐)티오 유도체

Country Status (7)

Country Link
US (1) US4954514A (ko)
EP (1) EP0380331B1 (ko)
JP (1) JP2627003B2 (ko)
KR (1) KR900011754A (ko)
AT (1) ATE98227T1 (ko)
DE (1) DE69004984T2 (ko)
DK (1) DK0380331T3 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5192791A (en) * 1988-09-26 1993-03-09 Biofor, Ltd. Fused ring heterocycles and pharmaceutical compositions containing same
WO1994001433A1 (en) * 1992-07-13 1994-01-20 Japan Tobacco Inc. Novel thiazolidinedione compound and use thereof
US5326907A (en) * 1992-12-18 1994-07-05 G. D. Searle & Co. 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers
DK0960096T3 (da) * 1997-01-22 2005-06-27 Aventis Pharma Inc Substituerede beta-thiocarboxylsyrer
US6670398B2 (en) 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
BR9809793A (pt) 1997-05-14 2000-06-27 Atherogenics Inc Monoésteres de probucol para o tratamento de doença inflamatória e cardiovascular
US6852878B2 (en) * 1998-05-14 2005-02-08 Atherogenics, Inc. Thioketals and thioethers for inhibiting the expression of VCAM-1
KR20010020611A (ko) * 1997-07-01 2001-03-15 아테로제닉스, 인코포레이티드 항산화제에 의한 과증식질병 치료의 향상
EP1127882A1 (en) * 2000-01-25 2001-08-29 Pfizer Products Inc. Tetrazole compounds as thyroid receptor ligands
US20030064967A1 (en) * 2001-04-11 2003-04-03 Jayraz Luchoomun Methods to increase plasma HDL cholesterol levels and improve HDL functionality with probucol monoesters
KR20050039700A (ko) * 2001-10-25 2005-04-29 아테로제닉스, 인코포레이티드 이식거부 치료용 화합물 및 치료 방법
IL161741A0 (en) * 2001-11-09 2005-11-20 Atherogenics Inc Methods of reversing and preventingcardiovascular pathologies
CA2492433A1 (en) * 2002-07-12 2004-01-22 Artherogenics, Inc. Organic amine salts of poorly soluble probucol esters and ethers
US20040110803A1 (en) * 2002-09-13 2004-06-10 Hossein Dovlatabadi Methods and compositions for the use of D-malic acid to decrease serum triglyceride, cholesterol and lipoprotein levels
WO2005112914A2 (en) 2004-04-20 2005-12-01 Atherogenics, Inc. Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7294737B2 (en) 2004-04-20 2007-11-13 Atherogenics, Inc. Process of preparing esters and ethers of probucol and derivatives thereof
US8252840B2 (en) 2007-03-26 2012-08-28 Salutria Pharmaceuticals Llc Methods of derivatives of probucol for the treatment of type II diabetes
US20080280985A1 (en) * 2007-03-27 2008-11-13 Scott Robert A D Methods and Compositions Using Certain Phenolic Derivatives for the Treatment of Diabetes
US7897776B2 (en) 2007-04-23 2011-03-01 Salutria Pharmaceuticals Llc Sulfonamide containing compounds for treatment of inflammatory disorders
CN103896815B (zh) * 2014-03-26 2016-03-30 安徽师范大学 一种邻位巯基苯酚衍生物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3337576A (en) * 1966-01-20 1967-08-22 Bristol Myers Co Arylthioalkyltetrazoles
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
CA1037964A (en) * 1973-02-14 1978-09-05 Eugene R. Wagner 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
AU584669B2 (en) * 1985-02-04 1989-06-01 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US4755524A (en) * 1986-01-31 1988-07-05 G. D. Searle & Co. Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Also Published As

Publication number Publication date
ATE98227T1 (de) 1993-12-15
JP2627003B2 (ja) 1997-07-02
DE69004984T2 (de) 1994-04-07
DK0380331T3 (da) 1994-02-14
DE69004984D1 (de) 1994-01-20
EP0380331A1 (en) 1990-08-01
EP0380331B1 (en) 1993-12-08
US4954514A (en) 1990-09-04
JPH02196770A (ja) 1990-08-03

Similar Documents

Publication Publication Date Title
KR900011754A (ko) (디-3급-부틸히드록시페닐)티오 유도체
RU94022258A (ru) Новые сульфониламинопиримидины
EP0992501A3 (en) Pyridonecarboxylic acid derivatives as antibacterial agents
KR890003720A (ko) 벤조티아졸 및 그를 유효성분으로 함유하는 항류머티스제
DK0378255T3 (da) 2-aminopyrimidinoderivater
DK0696281T3 (da) Hidtil ukendte 5-pyrrolyl-2-pyridylmethylsulfinylbenzimidazolderivater
DK0530505T3 (da) Hydantoinderivater
RU93054537A (ru) Производные гуанидиналкил-1,1-бисфосфоновой кислоты, способ их получения и их применение
DE69426602D1 (de) 2,3-diaminopropionsäurederivate
EA199700160A1 (ru) Производные индола в качестве антагонистов eaa
KR960007592A (ko) 신규한 피롤로카바졸
KR890011596A (ko) 불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
NO923200D0 (no) Piperidin-derivater
ATE144253T1 (de) Methanoanthracene als dopaminantagonisten
DE69330601T2 (de) Serotoninergische ergolin derivate
KR920007995A (ko) 벤즈아미드 유도체
ATE200291T1 (de) Cephemderivate
MX9206930A (es) Nuevos compuestos
KR940018351A (ko) 노나테트라에노산 유도체
DK0532177T3 (da) Methanoanthracener som dopaminantagonister
DK0876144T3 (da) Terapeutiske anti-astmamidler indeholdende organiske selenforbindelser
BR9504004A (pt) Composto processo para sua preparação e composição farmacêutica
FI960588A0 (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
KR900001663A (ko) 알케닐테트라졸 유도체
DE69528984D1 (de) Hemmung der leukotrienbiosynthese mittels harnstoffderivaten

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application