DE974343T1 - Zusammensetzung enthaltend Metoprolol und Verfahren zur Herstellung - Google Patents
Zusammensetzung enthaltend Metoprolol und Verfahren zur HerstellungInfo
- Publication number
- DE974343T1 DE974343T1 DE0974343T DE99202373T DE974343T1 DE 974343 T1 DE974343 T1 DE 974343T1 DE 0974343 T DE0974343 T DE 0974343T DE 99202373 T DE99202373 T DE 99202373T DE 974343 T1 DE974343 T1 DE 974343T1
- Authority
- DE
- Germany
- Prior art keywords
- mixing
- additives
- sufficient period
- time
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract 21
- 229960002237 metoprolol Drugs 0.000 title claims abstract 9
- IUBSYMUCCVWXPE-UHFFFAOYSA-N metoprolol Chemical compound COCCC1=CC=C(OCC(O)CNC(C)C)C=C1 IUBSYMUCCVWXPE-UHFFFAOYSA-N 0.000 title claims abstract 9
- 238000000034 method Methods 0.000 title claims 16
- 238000004519 manufacturing process Methods 0.000 title claims 5
- 239000000654 additive Substances 0.000 claims abstract 17
- 238000002156 mixing Methods 0.000 claims abstract 17
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims abstract 10
- 238000001035 drying Methods 0.000 claims abstract 8
- 239000008187 granular material Substances 0.000 claims abstract 4
- 239000003826 tablet Substances 0.000 claims abstract 4
- 239000002904 solvent Substances 0.000 claims abstract 3
- 239000011248 coating agent Substances 0.000 claims abstract 2
- 238000000576 coating method Methods 0.000 claims abstract 2
- 239000007891 compressed tablet Substances 0.000 claims abstract 2
- 239000007864 aqueous solution Substances 0.000 claims 7
- 239000012530 fluid Substances 0.000 claims 6
- 239000004615 ingredient Substances 0.000 claims 6
- 238000005469 granulation Methods 0.000 claims 5
- 230000003179 granulation Effects 0.000 claims 5
- 238000003825 pressing Methods 0.000 claims 5
- 239000004480 active ingredient Substances 0.000 claims 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
- 238000007873 sieving Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 1
- 239000011668 ascorbic acid Substances 0.000 claims 1
- 229960005070 ascorbic acid Drugs 0.000 claims 1
- 235000010323 ascorbic acid Nutrition 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 229960001375 lactose Drugs 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 229960001300 metoprolol tartrate Drugs 0.000 claims 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 1
- 239000008108 microcrystalline cellulose Substances 0.000 claims 1
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000049 pigment Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- WUBVEMGCQRSBBT-UHFFFAOYSA-N tert-butyl 4-(trifluoromethylsulfonyloxy)-3,6-dihydro-2h-pyridine-1-carboxylate Chemical group CC(C)(C)OC(=O)N1CCC(OS(=O)(=O)C(F)(F)F)=CC1 WUBVEMGCQRSBBT-UHFFFAOYSA-N 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/120,914 US6048547A (en) | 1996-04-15 | 1998-07-22 | Process for manufacturing solid compositions containing polyethylene oxide and an active ingredient |
| EP98402192A EP0987020A1 (en) | 1998-09-04 | 1998-09-04 | Metoprolol composition and processes for manufacturing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE974343T1 true DE974343T1 (de) | 2000-11-02 |
Family
ID=26151693
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69920590T Expired - Fee Related DE69920590T2 (de) | 1998-07-22 | 1999-07-19 | Verfahren zur Herstellung einer festen Zubereitung enthaltend Metoprolol |
| DE0974343T Pending DE974343T1 (de) | 1998-07-22 | 1999-07-19 | Zusammensetzung enthaltend Metoprolol und Verfahren zur Herstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69920590T Expired - Fee Related DE69920590T2 (de) | 1998-07-22 | 1999-07-19 | Verfahren zur Herstellung einer festen Zubereitung enthaltend Metoprolol |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | ATE277603T1 (ru) |
| BG (1) | BG64835B1 (ru) |
| DE (2) | DE69920590T2 (ru) |
| EA (1) | EA002188B1 (ru) |
| HK (1) | HK1024873A1 (ru) |
| HR (1) | HRP990230A2 (ru) |
| HU (1) | HUP9902351A3 (ru) |
| NO (1) | NO993588L (ru) |
| PL (1) | PL334592A1 (ru) |
| SK (1) | SK284766B6 (ru) |
| YU (1) | YU33999A (ru) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1146866A (en) * | 1979-07-05 | 1983-05-24 | Yamanouchi Pharmaceutical Co. Ltd. | Process for the production of sustained release pharmaceutical composition of solid medical material |
| ATE72111T1 (de) * | 1987-01-14 | 1992-02-15 | Ciba Geigy Ag | Therapeutisches system fuer schwerloesliche wirkstoffe. |
| DE69619979T2 (de) * | 1995-04-14 | 2002-11-21 | Pharma Pass, Illkirch Graffenstaden | Feste zusammensetzungen mit einem nicht-amorphem wirkstoff und polyäthylenoxyd |
-
1999
- 1999-07-12 HU HU9902351A patent/HUP9902351A3/hu unknown
- 1999-07-16 SK SK965-99A patent/SK284766B6/sk unknown
- 1999-07-19 AT AT99202373T patent/ATE277603T1/de not_active IP Right Cessation
- 1999-07-19 DE DE69920590T patent/DE69920590T2/de not_active Expired - Fee Related
- 1999-07-19 DE DE0974343T patent/DE974343T1/de active Pending
- 1999-07-20 BG BG103595A patent/BG64835B1/bg unknown
- 1999-07-21 HR HR98402192.3A patent/HRP990230A2/xx not_active Application Discontinuation
- 1999-07-21 EA EA199900583A patent/EA002188B1/ru not_active IP Right Cessation
- 1999-07-21 YU YU33999A patent/YU33999A/sh unknown
- 1999-07-22 NO NO993588A patent/NO993588L/no not_active Application Discontinuation
- 1999-07-22 PL PL99334592A patent/PL334592A1/xx not_active Application Discontinuation
-
2000
- 2000-07-06 HK HK00104152A patent/HK1024873A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NO993588L (no) | 2000-01-24 |
| YU33999A (sh) | 2002-03-18 |
| SK96599A3 (en) | 2000-02-14 |
| EA199900583A2 (ru) | 2000-02-28 |
| SK284766B6 (sk) | 2005-11-03 |
| BG103595A (en) | 2000-07-31 |
| ATE277603T1 (de) | 2004-10-15 |
| BG64835B1 (bg) | 2006-06-30 |
| HK1024873A1 (en) | 2000-10-27 |
| HRP990230A2 (en) | 2000-04-30 |
| NO993588D0 (no) | 1999-07-22 |
| HUP9902351A2 (hu) | 2000-12-28 |
| HUP9902351A3 (en) | 2001-01-29 |
| PL334592A1 (en) | 2000-01-31 |
| EA002188B1 (ru) | 2002-02-28 |
| DE69920590T2 (de) | 2006-04-06 |
| DE69920590D1 (de) | 2004-11-04 |
| EA199900583A3 (ru) | 2000-06-26 |
| HU9902351D0 (en) | 1999-10-28 |
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