DE69942613D1 - Einzelzellsuspension einer zelllinie von spodoptera frugiperda in serum-freiem medium und verfahren für ihre herstellung und verwendung - Google Patents
Einzelzellsuspension einer zelllinie von spodoptera frugiperda in serum-freiem medium und verfahren für ihre herstellung und verwendungInfo
- Publication number
- DE69942613D1 DE69942613D1 DE69942613T DE69942613T DE69942613D1 DE 69942613 D1 DE69942613 D1 DE 69942613D1 DE 69942613 T DE69942613 T DE 69942613T DE 69942613 T DE69942613 T DE 69942613T DE 69942613 D1 DE69942613 D1 DE 69942613D1
- Authority
- DE
- Germany
- Prior art keywords
- cell line
- serum
- spodoptera frugiperda
- preparation
- free medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000256251 Spodoptera frugiperda Species 0.000 title abstract 2
- 239000006285 cell suspension Substances 0.000 title 1
- 239000012679 serum free medium Substances 0.000 title 1
- 241000238631 Hexapoda Species 0.000 abstract 4
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- 241000255777 Lepidoptera Species 0.000 abstract 1
- 241000256259 Noctuidae Species 0.000 abstract 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 abstract 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 abstract 1
- 102000002938 Thrombospondin Human genes 0.000 abstract 1
- 108060008245 Thrombospondin Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 238000013320 baculovirus expression vector system Methods 0.000 abstract 1
- 238000010790 dilution Methods 0.000 abstract 1
- 239000012895 dilution Substances 0.000 abstract 1
- 239000012194 insect media Substances 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 241000701447 unidentified baculovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70514—CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0601—Invertebrate cells or tissues, e.g. insect cells; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
- C12N2500/92—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/169,178 US6103526A (en) | 1998-10-08 | 1998-10-08 | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
| PCT/US1999/022862 WO2000020561A1 (en) | 1998-10-08 | 1999-10-04 | Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69942613D1 true DE69942613D1 (de) | 2010-09-02 |
Family
ID=22614520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69942613T Expired - Lifetime DE69942613D1 (de) | 1998-10-08 | 1999-10-04 | Einzelzellsuspension einer zelllinie von spodoptera frugiperda in serum-freiem medium und verfahren für ihre herstellung und verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6103526A (de) |
| EP (1) | EP1119612B1 (de) |
| AT (1) | ATE474913T1 (de) |
| AU (1) | AU6282199A (de) |
| CA (1) | CA2346497C (de) |
| CY (1) | CY1110837T1 (de) |
| DE (1) | DE69942613D1 (de) |
| DK (1) | DK1119612T3 (de) |
| ES (1) | ES2347310T3 (de) |
| PT (1) | PT1119612E (de) |
| WO (1) | WO2000020561A1 (de) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8026096B1 (en) * | 1998-10-08 | 2011-09-27 | Protein Sciences Corporation | In vivo active erythropoietin produced in insect cells |
| US6342216B1 (en) * | 1999-03-17 | 2002-01-29 | The Board Of Regents, The University Of Texas System | Therapy of cancer by insect cells containing recombinant baculovirus encoding genes |
| US7345019B1 (en) * | 1999-04-13 | 2008-03-18 | The Kenneth S. Warren Institute, Inc. | Modulation of excitable tissue function by peripherally administered erythropoietin |
| US6379958B1 (en) * | 2000-05-24 | 2002-04-30 | The United States Of America As Represented By The Secretary Of Agriculture | Selected insect cell line clones providing increased yield of baculoviruses and gene expression products from recombinant baculoviruses |
| EP1285059A2 (de) | 2000-05-31 | 2003-02-26 | The Board Of Regents, The University Of Texas System | Adjuvanszusammensetzungen zur induzierung der spezifischen immunität |
| US20060177416A1 (en) * | 2003-10-14 | 2006-08-10 | Medivas, Llc | Polymer particle delivery compositions and methods of use |
| US20030072737A1 (en) * | 2000-12-29 | 2003-04-17 | Michael Brines | Tissue protective cytokines for the protection, restoration, and enhancement of responsive cells, tissues and organs |
| US7767643B2 (en) | 2000-12-29 | 2010-08-03 | The Kenneth S. Warren Institute, Inc. | Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs |
| EP2390352A1 (de) | 2003-03-18 | 2011-11-30 | Quantum Genetics Ireland Limited | Systeme und Methoden zur Erhöhung der Milchproduktion bei Tieren |
| US7468273B2 (en) | 2003-05-01 | 2008-12-23 | Meial Limited | Canine GHRH gene, polypeptides and methods of use |
| WO2005021713A2 (en) * | 2003-06-20 | 2005-03-10 | Protein Sciences Corporation | Vectors expressing sars immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using |
| US7645733B2 (en) * | 2003-09-29 | 2010-01-12 | The Kenneth S. Warren Institute, Inc. | Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions |
| US20050214316A1 (en) | 2003-11-13 | 2005-09-29 | Brown Thomas P | Methods of characterizing infectious bursal disease virus |
| AU2005244673B2 (en) | 2004-02-19 | 2009-12-10 | The Governors Of The University Of Alberta | Leptin promoter polymorphisms and uses thereof |
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| ES2343270T3 (es) | 2005-04-25 | 2010-07-27 | Merial Ltd. | Vacunas contra el virus nipah. |
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| WO2008057537A2 (en) * | 2006-11-08 | 2008-05-15 | Maine Medical Center Research | System and method for identifying erythropoietin-responsive genes |
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| WO2011112090A2 (en) | 2010-03-11 | 2011-09-15 | Amsterdam Molecular Therapeutics (Amt) Ip B.V. | Method for identifying variant rep protein encoding nucleic acids |
| US9228174B2 (en) | 2010-03-11 | 2016-01-05 | Uniqure Ip B.V. | Mutated rep encoding sequences for use in AAV production |
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| ES2674439T3 (es) | 2011-06-01 | 2018-06-29 | Merial, Inc. | Administración sin aguja de vacunas contra el VSRRP |
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| US9873765B2 (en) | 2011-06-23 | 2018-01-23 | Dsm Ip Assets, B.V. | Biodegradable polyesteramide copolymers for drug delivery |
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| CA2847604A1 (en) | 2011-09-08 | 2013-03-14 | Uniqure Ip B.V. | Removal of contaminating viruses from aav preparations |
| WO2013093629A2 (en) | 2011-12-20 | 2013-06-27 | Netherlands Cancer Institute | Modular vaccines, methods and compositions related thereto |
| WO2013138776A1 (en) | 2012-03-16 | 2013-09-19 | Merial Limited | Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g |
| GB201210357D0 (en) | 2012-06-12 | 2012-07-25 | Ucl Business Plc | Factor VIII sequences |
| ES2959747T3 (es) | 2013-02-15 | 2024-02-28 | Bioverativ Therapeutics Inc | Gen del factor VIII optimizado |
| WO2014164697A1 (en) | 2013-03-12 | 2014-10-09 | Merial Limited | Reverse genetics schmallenberg virus vaccine compositions, and methods of use thereof |
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| AU2015343369B2 (en) | 2014-11-03 | 2018-11-22 | Georgia Tech Research Corporation | Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus |
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| MX2019014943A (es) * | 2018-12-12 | 2020-08-06 | Cambridge Tech Llc | Vacuna universal contra la gripe. |
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| WO2023198702A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
| WO2023198663A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of snca |
| WO2023198745A1 (en) | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of apoe |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4879236A (en) * | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US5298418A (en) * | 1991-09-16 | 1994-03-29 | Boyce Thompson Institute For Plant Research, Inc. | Cell line isolated from larval midgut tissue of Trichoplusia ni |
-
1998
- 1998-10-08 US US09/169,178 patent/US6103526A/en not_active Expired - Lifetime
-
1999
- 1999-10-04 CA CA2346497A patent/CA2346497C/en not_active Expired - Lifetime
- 1999-10-04 AU AU62821/99A patent/AU6282199A/en not_active Abandoned
- 1999-10-04 DE DE69942613T patent/DE69942613D1/de not_active Expired - Lifetime
- 1999-10-04 ES ES99950093T patent/ES2347310T3/es not_active Expired - Lifetime
- 1999-10-04 PT PT99950093T patent/PT1119612E/pt unknown
- 1999-10-04 EP EP99950093A patent/EP1119612B1/de not_active Expired - Lifetime
- 1999-10-04 WO PCT/US1999/022862 patent/WO2000020561A1/en active Application Filing
- 1999-10-04 AT AT99950093T patent/ATE474913T1/de active
- 1999-10-04 DK DK99950093.7T patent/DK1119612T3/da active
-
2010
- 2010-10-20 CY CY20101100938T patent/CY1110837T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2346497C (en) | 2013-01-08 |
| US6103526A (en) | 2000-08-15 |
| PT1119612E (pt) | 2010-09-16 |
| DK1119612T3 (da) | 2010-10-25 |
| EP1119612A1 (de) | 2001-08-01 |
| AU6282199A (en) | 2000-04-26 |
| ATE474913T1 (de) | 2010-08-15 |
| EP1119612B1 (de) | 2010-07-21 |
| CY1110837T1 (el) | 2015-06-10 |
| CA2346497A1 (en) | 2000-04-13 |
| WO2000020561A1 (en) | 2000-04-13 |
| ES2347310T3 (es) | 2010-10-27 |
| EP1119612A4 (de) | 2005-01-12 |
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