CO5241323A1 - Linea celular productora de eritropoyetina humana recombinante . - Google Patents

Linea celular productora de eritropoyetina humana recombinante .

Info

Publication number
CO5241323A1
CO5241323A1 CO99069968A CO99069968A CO5241323A1 CO 5241323 A1 CO5241323 A1 CO 5241323A1 CO 99069968 A CO99069968 A CO 99069968A CO 99069968 A CO99069968 A CO 99069968A CO 5241323 A1 CO5241323 A1 CO 5241323A1
Authority
CO
Colombia
Prior art keywords
gene
epo
erythropoyetin
cellular
recombinant human
Prior art date
Application number
CO99069968A
Other languages
English (en)
Inventor
Miguel Carcagno
Marcello Criscuolo
Carlos Melo
Alejandro Vidal
Original Assignee
Bio Sidus S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25590826&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO5241323(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from ARP980105609 external-priority patent/AR008358A1/es
Priority claimed from ARP990100679 external-priority patent/AR008363A1/es
Application filed by Bio Sidus S A filed Critical Bio Sidus S A
Publication of CO5241323A1 publication Critical patent/CO5241323A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Habiendo descrito y ejemplificado la naturaleza y objeto principal de la presente invención, así como también la manera en que la misma se puede llevar a la práctica, se declara reivindicar como de propiedad y de derechos exclusivos: UN PROCEDIMIENTO PARA LA PURIFICACIÓN DE ERITROPOYETINA HUMANA RECOMBINANTE A PARTIR DE SOBRENADANTES DE CULTIVO DE CELULAS caracterizado por incluir las siguientes etapas: precipitación diferencial; cromatografía de interacción hidrofóbica; concentración y diafiltración; cromatografía de intercambio aniónico; cromatografía de intercambio catiónico; concentración y diafiltración; cromatografía de exclusión molecular.
CO99069968A 1998-11-06 1999-11-05 Linea celular productora de eritropoyetina humana recombinante . CO5241323A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ARP980105609 AR008358A1 (es) 1998-11-06 1998-11-06 Celulas huesped que expresan eritropoyetina humana recombinante y un metodo para producir un polipeptido de epo
ARP990100679 AR008363A1 (es) 1999-02-23 1999-02-23 Linea celular productora de eritropoyetina humana recombinante y la eritropoyetina humana recombinante producida por esta celula.

Publications (1)

Publication Number Publication Date
CO5241323A1 true CO5241323A1 (es) 2003-01-31

Family

ID=25590826

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99069968A CO5241323A1 (es) 1998-11-06 1999-11-05 Linea celular productora de eritropoyetina humana recombinante .

Country Status (10)

Country Link
EP (1) EP1124984B1 (es)
JP (2) JP2002529100A (es)
AT (1) ATE420199T1 (es)
AU (1) AU1470400A (es)
BR (1) BR9905867A (es)
CA (1) CA2350335C (es)
CO (1) CO5241323A1 (es)
DE (1) DE69940267D1 (es)
ES (1) ES2321048T3 (es)
WO (1) WO2000028066A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9917606A (pt) 1998-11-06 2002-12-31 Bio Sidus S A Procedimento para a purificação de eritropoetina humana recombinante a partir de sobrenadantes de cultivo de células e eritropoetina humana recombinante obtida com tal procedimento
BR9905868A (pt) 1998-11-06 2001-01-23 Bio Sidus S A Procedimento de cultivo massivo de células de mamìfero para a obtenção de eritropoetina humana, recombinante e a eritropoetina humana recombinante obtida com tal procedimento
US6777205B1 (en) 1998-11-06 2004-08-17 Sterrenbeld Biotechnologie North America, Inc. Host cells expressing recombinant human erythropoietin
WO2007017903A2 (en) * 2005-06-20 2007-02-15 Cadila Healthcare Limited Expression vector and methods of producing high levels of proteins
PT2592148T (pt) 2007-10-12 2018-11-12 Hoffmann La Roche Expressão proteica de múltiplos ácidos nucleicos
WO2011106298A1 (en) * 2010-02-25 2011-09-01 Dana-Farber Cancer Institute, Inc. Braf mutations conferring resistance to braf inhibitors
CN103864913A (zh) 2012-12-18 2014-06-18 联亚生技开发股份有限公司 重组蛋白
SG11201908127WA (en) 2017-03-10 2019-10-30 Hoffmann La Roche Method for producing multispecific antibodies

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010002A (en) * 1983-01-19 1991-04-23 Genentech, Inc. Human t-PA production using vectors coding DHFR protein
US4703008A (en) 1983-12-13 1987-10-27 Kiren-Amgen, Inc. DNA sequences encoding erythropoietin
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
JPS62501010A (ja) * 1984-12-04 1987-04-23 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド エリトロポエチンの生産方法
US5641663A (en) * 1985-11-06 1997-06-24 Cangene Corporation Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces
JPS62171696A (ja) * 1986-01-23 1987-07-28 Sumitomo Chem Co Ltd ヒトエリスロポエチンの製造方法
JPH02485A (ja) * 1987-08-03 1990-01-05 Yuu Honshiyo 新規なヒトインターロイキン４、該因子を発現させるための組換えベクター及びそのベクターにより形質転換された形質転換体
IL95064A0 (en) * 1990-07-12 1991-06-10 Yeda Res & Dev Molecular cloning of tnf binding protein
US5997856A (en) * 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
WO1993000807A1 (en) * 1991-07-03 1993-01-21 Cryolife, Inc. Method for stabilization of biomaterials
JPH05194253A (ja) * 1992-01-16 1993-08-03 Kirin Brewery Co Ltd 水溶性ポリペプチドホルモンを含む徐放性微小粒子状製剤及びその製造法
JP3790567B2 (ja) * 1994-09-30 2006-06-28 武田薬品工業株式会社 徐放剤
IL118201A (en) * 1995-05-11 2004-12-15 Roche Diagnostics Gmbh Preparation comprising a protein with human erythropoietin activity which is free of serum and non-recombinant mammalian protein and process for the preparation thereof
DE19539574A1 (de) * 1995-10-25 1997-04-30 Boehringer Mannheim Gmbh Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren
JPH09238688A (ja) * 1996-03-11 1997-09-16 Takeda Chem Ind Ltd ヒトｍｃｐ−１レセプタータンパク質の製造法および用途
US6632648B1 (en) * 1996-05-14 2003-10-14 Elan Drug Delivery Limited Methods of terminal sterilization of fibrinogen
US5851984A (en) * 1996-08-16 1998-12-22 Genentech, Inc. Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides
RU2245887C2 (ru) * 1996-10-25 2005-02-10 Джи. Ди. Сирл Энд Ко. Гемопоэтический белок (варианты), последовательность днк, способ получения гемопоэтического белка, способ селективной экспансии кроветворных клеток, способ продуцирования дендритных клеток, способ стимуляции продуцирования кроветворных клеток у пациента, фармацевтическая композиция, способ лечения
JPH10273447A (ja) * 1997-01-29 1998-10-13 Takeda Chem Ind Ltd 徐放性マイクロスフィア、その製造法および用途

Also Published As

Publication number Publication date
JP2002529100A (ja) 2002-09-10
ATE420199T1 (de) 2009-01-15
JP2010213699A (ja) 2010-09-30
BR9905867A (pt) 2001-01-23
ES2321048T3 (es) 2009-06-01
WO2000028066A1 (en) 2000-05-18
EP1124984A1 (en) 2001-08-22
EP1124984A4 (en) 2005-05-04
CA2350335A1 (en) 2000-05-18
CA2350335C (en) 2013-02-26
DE69940267D1 (de) 2009-02-26
AU1470400A (en) 2000-05-29
EP1124984B1 (en) 2009-01-07

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