DE69941604D1 - Cytochrom P450 Monooxygenase Gen und Protein des Omega-Hydroxylase-Komplexes von Candida Tropicalis und darauf bezogene Verfahren - Google Patents

Cytochrom P450 Monooxygenase Gen und Protein des Omega-Hydroxylase-Komplexes von Candida Tropicalis und darauf bezogene Verfahren

Info

Publication number
DE69941604D1
DE69941604D1 DE69941604T DE69941604T DE69941604D1 DE 69941604 D1 DE69941604 D1 DE 69941604D1 DE 69941604 T DE69941604 T DE 69941604T DE 69941604 T DE69941604 T DE 69941604T DE 69941604 D1 DE69941604 D1 DE 69941604D1
Authority
DE
Germany
Prior art keywords
cytochrome
enzymes
genes
methods
omega
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941604T
Other languages
English (en)
Inventor
Ron C Wilson
David L Craft
Dudley L Eirich
Mark Eshoo
Krishna M Madduri
Cathy A Cornett
Alfred A Brenner
Maria Tang
John C Loper
Martin Gleeson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cognis IP Management GmbH
Original Assignee
Cognis IP Management GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cognis IP Management GmbH filed Critical Cognis IP Management GmbH
Application granted granted Critical
Publication of DE69941604D1 publication Critical patent/DE69941604D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
    • C12N9/0042—NADPH-cytochrome P450 reductase (1.6.2.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69941604T 1998-10-05 1999-09-10 Cytochrom P450 Monooxygenase Gen und Protein des Omega-Hydroxylase-Komplexes von Candida Tropicalis und darauf bezogene Verfahren Expired - Lifetime DE69941604D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10309998P 1998-10-05 1998-10-05
US12355599P 1999-03-10 1999-03-10

Publications (1)

Publication Number Publication Date
DE69941604D1 true DE69941604D1 (de) 2009-12-10

Family

ID=26800090

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69941604T Expired - Lifetime DE69941604D1 (de) 1998-10-05 1999-09-10 Cytochrom P450 Monooxygenase Gen und Protein des Omega-Hydroxylase-Komplexes von Candida Tropicalis und darauf bezogene Verfahren
DE69941603T Expired - Lifetime DE69941603D1 (de) 1998-10-05 1999-09-10 Cytochrom P450 Monooxygenase Gen und Protein des omega-Hydroxylase-Komplexes von Candida tropicalis und darauf bezogene Verfahren
DE69924873T Expired - Lifetime DE69924873T2 (de) 1998-10-05 1999-09-10 Cytochrom p450 monooxygenase und nadph-cytochrom p450-oxidoreduktase gene und proteine mit bezug zum omega-hydroxylase-komplex in candida tropicalis und dazu gehörigen verfahren

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69941603T Expired - Lifetime DE69941603D1 (de) 1998-10-05 1999-09-10 Cytochrom P450 Monooxygenase Gen und Protein des omega-Hydroxylase-Komplexes von Candida tropicalis und darauf bezogene Verfahren
DE69924873T Expired - Lifetime DE69924873T2 (de) 1998-10-05 1999-09-10 Cytochrom p450 monooxygenase und nadph-cytochrom p450-oxidoreduktase gene und proteine mit bezug zum omega-hydroxylase-komplex in candida tropicalis und dazu gehörigen verfahren

Country Status (7)

Country Link
EP (12) EP1148133A3 (de)
AT (3) ATE447028T1 (de)
AU (1) AU5917799A (de)
CA (2) CA2349868C (de)
DE (3) DE69941604D1 (de)
ES (1) ES2243075T3 (de)
WO (1) WO2000020566A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7610200A (en) 1999-09-30 2001-05-10 Cognis Corporation Improved fermentation process
US20020061566A1 (en) 2000-03-20 2002-05-23 Eirich L. Dudley Biooxidation capabilities of candida sp
US6660505B2 (en) 2000-06-22 2003-12-09 Cognis Corporation Isolation of carboxylic acids from fermentation broth
US6673613B2 (en) * 2000-07-26 2004-01-06 Cognis Corporation Use of CYP52A2A promoter to increase gene expression in yeast
WO2003031596A2 (en) * 2001-10-12 2003-04-17 Cognis Corporation Production of a highly active, soluble form of the cytochrome p450 reductase (cpr a) from candida tropicalis
AU2003247411A1 (en) 2002-05-23 2003-12-12 Cognis Corporation NON-REVERTIBLE Beta-OXIDATION BLOCKED CANDIDA TROPICALIS
US6777213B2 (en) 2002-10-29 2004-08-17 Cognis Corporation Isolation of carboxylic acids from fermentation broth
CN100591754C (zh) * 2005-10-14 2010-02-24 中国科学院大连化学物理研究所 一种共表达cyp和cpr的酵母系统
DE102007060705A1 (de) 2007-12-17 2009-06-18 Evonik Degussa Gmbh ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen
DE102009046626A1 (de) 2009-11-11 2011-05-12 Evonik Degussa Gmbh Candida tropicalis Zellen und deren Verwendung
DE102010015807A1 (de) 2010-04-20 2011-10-20 Evonik Degussa Gmbh Biokatalytisches Oxidationsverfahren mit alkL-Genprodukt
EP2944697A1 (de) 2014-05-13 2015-11-18 Evonik Degussa GmbH Verfahren zur Herstellung von Nylon
WO2017102952A1 (en) 2015-12-17 2017-06-22 Evonik Degussa Gmbh A genetically modified acetogenic cell
MY187786A (en) 2016-07-27 2021-10-22 Evonik Operations Gmbh N-acetyl homoserine
US20200010862A1 (en) * 2018-07-06 2020-01-09 Cathay Biotech Inc. Long-chain dibasic acid with low content of fatty acid impurity and a method of producing the same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1365689A (en) 1970-12-26 1974-09-04 Hasegawa T Co Ltd Process for the production of carboxylic acids
DE2140133C2 (de) 1971-08-10 1984-08-09 Ajinomoto Co., Inc., Tokio Verfahren zur mikrobiologischen Herstellung von α,ω-n-Alkandicarbonsäuren
JPS5543759B2 (de) 1972-06-28 1980-11-07
US3975234A (en) 1975-07-03 1976-08-17 Phillips Petroleum Company Microbial production of dicarboxylic acids
JPS5946598B2 (ja) 1977-12-14 1984-11-13 株式会社バイオリサ−チセンタ− 微生物による長鎖脂肪酸類の製造法
JPS5539778A (en) 1978-09-14 1980-03-19 Baiorisaac Center:Kk Microbial preparation of carboxylic acid composed mainly of omega,omega-1-dihydroxy acid
JPS5592691A (en) 1978-12-28 1980-07-14 Baiorisaac Center:Kk Purification of dicarboxylic acid produced by fermentation
US4339536A (en) 1979-06-08 1982-07-13 Nippon Mining Co., Ltd. Process for the preparation of long-chain dicarboxylic acids by fermentation
JPS5765194A (en) 1980-10-09 1982-04-20 Daicel Chem Ind Ltd Microbial preparation of unsaturated dicarboxylic acid
US5254466A (en) 1989-11-06 1993-10-19 Henkel Research Corporation Site-specific modification of the candida tropicals genome
WO1991014781A1 (en) * 1990-03-19 1991-10-03 Henkel Research Corporation METHOD FOR INCREASING THE OMEGA-HYDROXYLASE ACTIVITY IN $i(CANDIDA TROPICALIS)
US6331420B1 (en) 1998-05-01 2001-12-18 C. Ron Wilson Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto
US6503734B1 (en) 2000-07-26 2003-01-07 Cognis Corporation Cytochrome b5 gene and protein of Candida tropicalis and methods relating thereto
US7388084B2 (en) * 2002-08-16 2008-06-17 Cognis Corporation Promoter motifs in Candida tropicalis
DE102007042592A1 (de) 2007-09-07 2009-03-26 Siemens Medical Instruments Pte. Ltd. Übertragungseinrichtung für eine Hörvorrichtung mit Folienleiterschirmung und eigengeschirmte Spule

Also Published As

Publication number Publication date
DE69924873D1 (de) 2005-05-25
EP1148135A2 (de) 2001-10-24
EP1162268A3 (de) 2002-01-16
DE69941603D1 (de) 2009-12-10
EP1148134A3 (de) 2002-01-16
AU5917799A (en) 2000-04-26
EP1148132A3 (de) 2002-01-16
EP1148131A2 (de) 2001-10-24
EP1162268A2 (de) 2001-12-12
EP1148133A2 (de) 2001-10-24
EP1148138A2 (de) 2001-10-24
EP1148130A2 (de) 2001-10-24
CA2653985A1 (en) 2000-04-13
WO2000020566A9 (en) 2000-08-24
EP1148136A2 (de) 2001-10-24
EP1148136A3 (de) 2002-01-16
EP1148137A3 (de) 2002-01-16
EP1148143A2 (de) 2001-10-24
EP1148143A3 (de) 2002-01-16
EP1148131A3 (de) 2002-01-16
CA2349868A1 (en) 2000-04-13
EP1135506A2 (de) 2001-09-26
EP1148132A2 (de) 2001-10-24
EP1148134B1 (de) 2009-10-28
ATE447028T1 (de) 2009-11-15
EP1148135A3 (de) 2002-01-16
DE69924873T2 (de) 2006-03-02
ES2243075T3 (es) 2005-11-16
EP1148131B1 (de) 2009-10-28
WO2000020566A2 (en) 2000-04-13
ATE293694T1 (de) 2005-05-15
EP1148130A3 (de) 2002-01-16
ATE447029T1 (de) 2009-11-15
CA2349868C (en) 2010-07-20
EP1148136B1 (de) 2012-12-05
WO2000020566A3 (en) 2000-10-12
EP1148137A2 (de) 2001-10-24
EP1148138A3 (de) 2002-01-16
EP1148134A2 (de) 2001-10-24
EP1148133A3 (de) 2002-01-16
EP1135506B1 (de) 2005-04-20

Similar Documents

Publication Publication Date Title
ATE447028T1 (de) Cytochrom p450 monooxygenase gen und protein des omega-hydroxylase-komplexes von candida tropicalis und darauf bezogene verfahren
Embley et al. Hydrogenosomes, mitochondria and early eukaryotic evolution
Maeda et al. Protein engineering of hydrogenase 3 to enhance hydrogen production
CN101743310A (zh) 全局转录机器的改造
Yin et al. Genome shuffling of Saccharomyces cerevisiae for enhanced glutathione yield and relative gene expression analysis using fluorescent quantitation reverse transcription polymerase chain reaction
Ataai et al. A mathematical model for prediction of plasmid copy number and genetic stability in Escherichia coli
ATE395424T1 (de) Verfahren zur herstellung von heterologen polypeptiden in trichothecene mangelmutanten filamentlösen pilzen
Postma et al. Modular, synthetic chromosomes as new tools for large scale engineering of metabolism
Hopwood The genetic programming of industrial microorganisms
DE60132091D1 (de) Candida tropicalis cytochrom b5 gen und protein und verwendungen davon
Barahona et al. A directed genome evolution method to enhance hydrogen production in Rhodobacter capsulatus
Žužek et al. Optimization of fermentation medium by a modified method of genetic algorithms
CN116240187A (zh) 脯氨酰羟化酶α1亚基突变体、编码基因及其在催化脯氨酸羟基化中的应用
Maleszka et al. Ethanol production from various sugars by strains of Pachysolen tannophilus bearing different numbers of chromosomes
EP1299532B1 (de) Verbesserte kombinatorische genbanken durch rekombination in hefe und analyseverfahren
AU2011201125A1 (en) Method for biotechnological production of a hydrogen carrier
Li CRISPR/Cas9-Enabled Functional Genomic Editing in the Thermotolerant Yeast Kluyveromyces Marxianus
JP6616286B2 (ja) 調節可能な遺伝子発現
O’Kennedy et al. The isolation of strains of Saccharomyces cerevisiae showing altered plasmid stability characteristics by means of selective continuous culture
Bruger et al. Genetic context significantly influences the maintenance and evolution of degenerate pathways
JP6284139B2 (ja) 接合能を有する酵母のスクリーニング方法
Gónzalez de Heredia et al. Session V SV-CO-1 Engineering a hydrogen biosensor in the nitrogen-fixing strain Rhodobacter capsulatus.
BETTAG STUDIES OF A DELTA (5)-3-KETOSTEROID ISOMERASE AND 5 ALPHA REDUCTASE FOUND IN SACCHAROMYCES CEREVISIAE.
Cournac Interactions between photosynthetic,(chloro) respiratory and hydrogen oxidoreduction pathways in algae and cyanobacteria
JPH06508761A (ja) 異種遺伝子を安定に組み込んだ酵母菌株

Legal Events

Date Code Title Description
8364 No opposition during term of opposition