DE69934242D1 - Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen - Google Patents
Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungenInfo
- Publication number
- DE69934242D1 DE69934242D1 DE69934242T DE69934242T DE69934242D1 DE 69934242 D1 DE69934242 D1 DE 69934242D1 DE 69934242 T DE69934242 T DE 69934242T DE 69934242 T DE69934242 T DE 69934242T DE 69934242 D1 DE69934242 D1 DE 69934242D1
- Authority
- DE
- Germany
- Prior art keywords
- polycetide
- preparation
- recombinant dna
- dna constructs
- synthase enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C12P19/30—Nucleotides
- C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10274898P | 1998-10-02 | 1998-10-02 | |
US102748P | 1998-10-02 | ||
US12381099P | 1999-03-11 | 1999-03-11 | |
US123810P | 1999-03-11 | ||
US13965099P | 1999-06-17 | 1999-06-17 | |
US139650P | 1999-06-17 | ||
PCT/US1999/022886 WO2000020601A2 (en) | 1998-10-02 | 1999-10-01 | Polyketide synthase enzymes and recombinant dna constructs therefor |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69934242D1 true DE69934242D1 (de) | 2007-01-11 |
DE69934242T2 DE69934242T2 (de) | 2007-09-20 |
Family
ID=27379409
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69934242T Expired - Fee Related DE69934242T2 (de) | 1998-10-02 | 1999-10-01 | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen |
Country Status (13)
Country | Link |
---|---|
US (5) | US6503737B1 (de) |
EP (1) | EP1117801B1 (de) |
JP (1) | JP2002526114A (de) |
KR (1) | KR20010085877A (de) |
CN (1) | CN1329668A (de) |
AT (1) | ATE346938T1 (de) |
AU (2) | AU773517B2 (de) |
CA (1) | CA2343880C (de) |
DE (1) | DE69934242T2 (de) |
IL (1) | IL142165A0 (de) |
MX (1) | MXPA01003376A (de) |
NZ (1) | NZ510819A (de) |
WO (1) | WO2000020601A2 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
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JP4579351B2 (ja) | 1996-12-03 | 2010-11-10 | スローン−ケッタリング インスティトュート フォア キャンサー リサーチ | エポチロンの合成とその中間体及びその類似物並びにその使用 |
US6204388B1 (en) * | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
ATE346938T1 (de) * | 1998-10-02 | 2006-12-15 | Kosan Biosciences Inc | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen |
US6569867B2 (en) | 1999-10-01 | 2003-05-27 | Kosan Biosciences, Inc. | Polyketide derivatives |
JP5142435B2 (ja) * | 1999-10-13 | 2013-02-13 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | ポリケチド合成基質の生合成 |
US6939691B1 (en) | 1999-10-13 | 2005-09-06 | Board Of Trustees Of The Leland Stanford Junior University | E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production |
US6627427B1 (en) * | 1999-10-25 | 2003-09-30 | Kosan Biosciences, Inc. | Heterologous production of 15-methyl-6-deoxyerthronolide B |
AU1105201A (en) * | 1999-10-27 | 2001-05-08 | Kosan Biosciences, Inc. | Heterologous production of polyketides |
ATE356880T1 (de) | 1999-10-29 | 2007-04-15 | Kosan Biosciences Inc | Rapamycin analoge |
US6562795B2 (en) | 2000-02-18 | 2003-05-13 | Kosan Biosciences, Inc. | Motilide compounds |
CA2407259A1 (en) * | 2000-05-17 | 2001-11-22 | Chaitan Khosla | Polyketide derivatives |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
JP2005506044A (ja) * | 2001-02-28 | 2005-03-03 | ザ、ボード、オブ、トラスティーズ、オブ、ザ、リーランド、スタンフォード、ジュニア、ユニバーシティ | ポリケチドシンターゼ基質の生合成 |
FR2825717B1 (fr) | 2001-06-08 | 2005-02-18 | Rhodia Chimie Sa | Preparation stereoselective de l-acides amines cycliques |
US7452692B2 (en) * | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
US7432074B2 (en) * | 2002-02-13 | 2008-10-07 | TEVA Gyógyszergyár Zártkörüen MüködöRészvénytársaság | Method for extracting a macrolide from biomatter |
JP4765032B2 (ja) | 2002-02-19 | 2011-09-07 | ダウ・アグロサイエンス・エル・エル・シー | 新規スピノシンを産生するポリケチド合成酵素 |
US7195907B2 (en) | 2002-03-29 | 2007-03-27 | Wyeth | Non-ribosomal peptide synthetases and associated biosynthetic genes |
WO2003082909A1 (en) * | 2002-03-29 | 2003-10-09 | Wyeth | Non-ribosomal peptide synthetases and associated biosynthetic genes |
DE60315723T2 (de) * | 2002-07-16 | 2008-06-19 | Biotica Technology Ltd. | Herstellung von Polyketiden und anderen natürlichen Produkten |
AU2007237187B2 (en) * | 2002-07-16 | 2010-08-05 | Biotica Technology Limited | Production of polyketides |
DK1767535T3 (da) * | 2002-08-23 | 2010-04-12 | Sloan Kettering Inst Cancer | Syntese af epothiloner, mellemprodukter deraf, analoge og deres anvendelse |
US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
US7799904B2 (en) * | 2003-06-13 | 2010-09-21 | University Of Kentucky Research Foundation | Gilvocarcin gene cluster, recombinant production and use thereof |
KR20060110865A (ko) * | 2003-11-27 | 2006-10-25 | 에자이 가부시키가이샤 | 매크로라이드계 화합물의 수산화에 관여하는 dna |
FR2869044B1 (fr) * | 2004-04-16 | 2006-07-14 | Korea Advanced Inst Sci & Tech | Genes pour la synthese de polyketides fr-008 |
EP1751279A4 (de) * | 2004-05-05 | 2008-03-19 | Univ Minnesota | An der herstellung von cryptophycin beteiligte nukleinsäuren und polypeptide |
WO2005109236A2 (en) * | 2004-05-06 | 2005-11-17 | Acco Brands, Inc. | Apparatus and method for determining an optimal ergonomic setup |
AU2005252673A1 (en) * | 2004-06-03 | 2005-12-22 | Wyeth | Biosynthetic gene cluster for the production of a complex polyketide |
KR100834488B1 (ko) * | 2004-07-20 | 2008-06-09 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 플라디에놀라이드의 생합성에 관여하는 폴리펩티드를코딩하는 dna |
WO2006069333A1 (en) * | 2004-12-22 | 2006-06-29 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Method of purifying macrolides |
WO2006083486A1 (en) * | 2005-01-05 | 2006-08-10 | TEVA GYÓGYSZERGYÁR ZÁRTKöR..EN M..k..D.. RÉSZVÉNYTÁRSASÁG | Amorphous tacrolimus and preparation thereof |
TW200716744A (en) * | 2005-05-26 | 2007-05-01 | Eisai R&D Man Co Ltd | Genetically modified microorganism and process for production of macrolide compound using the microorganism |
DE602007006601D1 (de) * | 2006-03-15 | 2010-07-01 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von tacrolimus |
US7566558B2 (en) * | 2006-07-28 | 2009-07-28 | Regents Of The University Of Michigan | Nucleic acids and polypeptides involved in the production of cryptophycin |
US8759031B2 (en) * | 2007-04-12 | 2014-06-24 | Wisconsin Alumni Research Foundation | Type I polyketide synthase extender units |
EP2272963A1 (de) | 2009-07-09 | 2011-01-12 | LEK Pharmaceuticals d.d. | Verfahren zur Herstellung von Tacrolimus |
KR101189475B1 (ko) * | 2009-12-03 | 2012-10-15 | (주) 제노텍 | 삼원환 화합물의 생합성을 담당하는 유전자와 단백질 |
US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
MX2013008062A (es) | 2011-01-28 | 2013-08-09 | Amyris Inc | Seleccion de microcolonias encapsuladas en gel. |
WO2012158466A1 (en) | 2011-05-13 | 2012-11-22 | Amyris, Inc. | Methods and compositions for detecting microbial production of water-immiscible compounds |
MX356894B (es) | 2011-09-19 | 2018-06-19 | Dow Global Technologies Llc | Estructuras por capas y artículos a partir de las mismas. |
US10927382B2 (en) | 2012-08-07 | 2021-02-23 | Amyris, Inc. | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
US9410214B2 (en) | 2013-03-15 | 2016-08-09 | Amyris, Inc. | Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme A derived compounds |
WO2015020649A1 (en) | 2013-08-07 | 2015-02-12 | Amyris, Inc. | Methods for stabilizing production of acetyl-coenzyme a derived compounds |
US10533016B2 (en) | 2015-01-09 | 2020-01-14 | Revolution Medicines, Inc. | Compounds that participate in cooperative binding and uses thereof |
BR112017027869A2 (pt) | 2015-06-25 | 2018-09-11 | Amyris, Inc. | degrons dependentes de maltose, promotores responsivos à maltose, construtos de estabilização, e seu uso na produção de compostos não catabólicos |
US9989535B2 (en) | 2015-10-01 | 2018-06-05 | Warp Drive Bio, Inc. | Methods and reagents for analyzing protein-protein interfaces |
KR102615448B1 (ko) | 2016-04-12 | 2023-12-19 | 징코 바이오웍스, 인크. | 화합물의 제조를 위한 조성물 및 방법 |
EP3532633A4 (de) | 2016-10-28 | 2020-09-09 | Ginkgo Bioworks Inc. | Zusammensetzungen und verfahren zur herstellung von verbindungen |
WO2018081590A1 (en) * | 2016-10-28 | 2018-05-03 | Warp Drive Bio, Inc. | Compositions and methods for the production of compounds |
KR102109168B1 (ko) * | 2018-12-11 | 2020-05-12 | 인트론바이오테크놀로지 | 신규 화합물 및 이를 포함하는 진균감염 치료용 약학적 조성물 |
CN109943545B (zh) * | 2019-03-29 | 2021-08-03 | 浙江大学 | 一种酰基转移酶结构域定向改造合成化合物的方法 |
US11827837B2 (en) * | 2019-04-02 | 2023-11-28 | King Fahd University Of Petroleum And Minerals | Water-based drilling, completion, and workover fluid composition with reduced barite sagging |
KR20220109408A (ko) | 2019-11-04 | 2022-08-04 | 레볼루션 메디슨즈, 인크. | Ras 억제제 |
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EP4055028A1 (de) | 2019-11-04 | 2022-09-14 | Revolution Medicines, Inc. | Ras-inhibitoren |
TW202227460A (zh) | 2020-09-15 | 2022-07-16 | 美商銳新醫藥公司 | Ras抑制劑 |
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US4894366A (en) * | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
US5149639A (en) | 1986-03-24 | 1992-09-22 | Abbott Laboratories | Biologically pure cultures of streptomyces and use thereof in macrolide antibiotic production |
US4874748A (en) | 1986-03-24 | 1989-10-17 | Abbott Laboratories | Cloning vectors for streptomyces and use thereof in macrolide antibiotic production |
EP0346427B1 (de) | 1987-12-09 | 1995-03-29 | FISONS plc | Makrozyklische verbindungen |
US5063155A (en) | 1988-03-28 | 1991-11-05 | Eli Lilly And Company | Method for producing 2"'-o-demethyltylosin |
US5098837A (en) | 1988-06-07 | 1992-03-24 | Eli Lilly And Company | Macrolide biosynthetic genes for use in streptomyces and other organisms |
EP0356399A3 (de) | 1988-08-26 | 1991-03-20 | Sandoz Ag | Substituierte 4-Azatricyclo (22.3.1.04.9) octacos-18-en-Derivate, Verfahren zu ihrer Herstellung und die sie enthaltenden pharmazeutischen Zusammensetzungen |
CA2044846A1 (en) | 1990-06-25 | 1991-12-26 | Thomas R. Beattie | Antagonists of immunosuppressive macrolides |
US5824513A (en) | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
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US5712146A (en) | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
US5672491A (en) | 1993-09-20 | 1997-09-30 | The Leland Stanford Junior University | Recombinant production of novel polyketides |
NZ313383A (en) | 1995-07-06 | 1999-08-30 | Univ Leland Stanford Junior | Cell-free synthesis of polyketides using pks (polyketide synthase) |
US6033883A (en) | 1996-12-18 | 2000-03-07 | Kosan Biosciences, Inc. | Production of polyketides in bacteria and yeast |
CA2288030A1 (en) | 1997-04-30 | 1998-11-05 | Kosan Biosciences, Inc. | Combinatorial polyketide libraries produced using a modular pks gene cluster as scaffold |
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FR2780774B1 (fr) * | 1998-07-03 | 2001-03-09 | Alkan Sa | Dispositif d'autoprotection passive pour engin mobile tel qu'un helicoptere |
US6150513A (en) | 1998-09-16 | 2000-11-21 | Kosan Biosciences, Inc. | Polyketide synthase enzymes and recombinant DNA constructs therefor |
ATE346938T1 (de) * | 1998-10-02 | 2006-12-15 | Kosan Biosciences Inc | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen |
-
1999
- 1999-10-01 AT AT99970125T patent/ATE346938T1/de not_active IP Right Cessation
- 1999-10-01 DE DE69934242T patent/DE69934242T2/de not_active Expired - Fee Related
- 1999-10-01 JP JP2000574696A patent/JP2002526114A/ja active Pending
- 1999-10-01 AU AU14415/00A patent/AU773517B2/en not_active Ceased
- 1999-10-01 US US09/410,551 patent/US6503737B1/en not_active Expired - Lifetime
- 1999-10-01 KR KR1020017004222A patent/KR20010085877A/ko not_active Application Discontinuation
- 1999-10-01 MX MXPA01003376A patent/MXPA01003376A/es not_active IP Right Cessation
- 1999-10-01 CN CN99813957A patent/CN1329668A/zh active Pending
- 1999-10-01 WO PCT/US1999/022886 patent/WO2000020601A2/en active IP Right Grant
- 1999-10-01 EP EP99970125A patent/EP1117801B1/de not_active Expired - Lifetime
- 1999-10-01 CA CA002343880A patent/CA2343880C/en not_active Expired - Fee Related
- 1999-10-01 IL IL14216599A patent/IL142165A0/xx unknown
- 1999-10-01 NZ NZ510819A patent/NZ510819A/xx unknown
-
2001
- 2001-04-03 US US09/825,621 patent/US6660862B2/en not_active Ceased
- 2001-08-27 US US09/940,316 patent/US6759536B2/en not_active Expired - Lifetime
-
2004
- 2004-05-25 AU AU2004202308A patent/AU2004202308A1/en not_active Abandoned
- 2004-07-06 US US10/885,305 patent/US7714118B2/en not_active Expired - Lifetime
-
2005
- 2005-12-09 US US11/299,244 patent/USRE39762E1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1117801B1 (de) | 2006-11-29 |
CA2343880C (en) | 2008-08-26 |
KR20010085877A (ko) | 2001-09-07 |
ATE346938T1 (de) | 2006-12-15 |
USRE39762E1 (en) | 2007-08-07 |
WO2000020601A9 (en) | 2000-08-31 |
MXPA01003376A (es) | 2002-11-07 |
AU2004202308A1 (en) | 2004-06-24 |
CN1329668A (zh) | 2002-01-02 |
AU773517B2 (en) | 2004-05-27 |
US20020010328A1 (en) | 2002-01-24 |
CA2343880A1 (en) | 2000-04-13 |
NZ510819A (en) | 2004-03-26 |
IL142165A0 (en) | 2002-03-10 |
US6660862B2 (en) | 2003-12-09 |
WO2000020601A2 (en) | 2000-04-13 |
US6503737B1 (en) | 2003-01-07 |
WO2000020601A3 (en) | 2000-10-26 |
AU1441500A (en) | 2000-04-26 |
JP2002526114A (ja) | 2002-08-20 |
US20090186378A1 (en) | 2009-07-23 |
US6759536B2 (en) | 2004-07-06 |
EP1117801A2 (de) | 2001-07-25 |
DE69934242T2 (de) | 2007-09-20 |
US20030175901A1 (en) | 2003-09-18 |
US7714118B2 (en) | 2010-05-11 |
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