KR101189475B1 - 삼원환 화합물의 생합성을 담당하는 유전자와 단백질 - Google Patents
삼원환 화합물의 생합성을 담당하는 유전자와 단백질 Download PDFInfo
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Abstract
미생물, 특히 방선균속에 의해 생산되는 삼원환 화합물(tricyclocompounds), 특히 타크롤리무스(tacrolimus, FK506)와 그 구조유사체인 다이하이드로-타크롤리무스, 아스코마이신(ascomycin, FK520), 프롤릴 타크롤리무스(prolyl-tacrolimus; FK525), FK523 등의 생합성에 사용되는 유전자좌(biosynthetic loci)를 구성하고 있는 유전자와 그가 코딩하고 있는 단백질에 관한 것이다. 이들 유전자와 단백질은 타크롤리무스, 아스코마이신 및 그와 연관된 화학구조물질의 생산, 화학적 변형 및 불순물 저감에 사용될 수 있다.
타크롤리무스, 아스코마이신, 생합성 유전자, 삼원환 화합물
Description
본 발명은 폴리케타이드류(polyketides), 특히 삼원환 화합물(tricyclocompounds) 더욱 특히, 면역억제제로 사용되고 있는 타크롤리무스와 그 유연물질의 생합성에 직접적으로 관계하는 유전자의 핵산 서열과 그 서열로부터 생산되는 단백질 및 이를 이용한 활성물질의 생산방법에 관한 것이다.
삼원환 화합물(Tricyclocompounds)은 주로 미생물, 특히 방선균 속이 생산하는 항진균 활성 및 면역억제 활성을 보이는 미생물 이차 대사 산물이다. 이들 물질은 일반적으로 독성이 매우 약하고 약리활성이 매우 높아 면역억제제, 항암제 등으로 개발되었으며, 프로그랍(PrografTM), 라파뮨(RapamuneTM) 등과 같은 고가의 의약품으로 판매되고 있다.
대표적인 삼원환 화합물로서 타크롤리무스(tacrolimus, FK506), 아스코마이신(ascomycin, FK520), 라파마이신(rapamycin, sirolimus), 메리다마이 신(meridamycin) 등이 알려져 있다.
타크롤리무스, 라파마이신, 아스코마이신과 그 구조 유사체들은 유사 구조 부위를 가지고 있어 인비보(in vivo)와 인비트로(in vitro)에서 면역세포인 T 세포의 활성화를 억제한다. 이들 화합물은 피라노스-피페콜린 영역(pyranose-pipecolinyl region)(도 1의 C1~C15)을 가지고 있는데 이는 루이신-프롤린 펩타이드(leucine-proline peptide)와 유사한 구조로서, 펩티딜 프로릴 시스/트랜스 이성화 효소 (peptidyl prolyl cis/trans isomerase)의 결합으로 다양한 생리적 활성을 나타낸다고 보고되었다 (Rosen M. K. 등, 1990).
아스코마이신은 23개의 탄소로 형성되는 마크롤라이드(23-membered macrolide) 구조의 화합물이며, 타크롤리무스의 에틸 유사체(ethyl analog)이다 (도 1 참조)(Hatanaka H. 등, 1998). 그리고 다이하이드로타크롤리무스 (dihydrotacrolimus)는 타크롤리무스 C21 위치의 프로필 유사체 (propyl analog)이고, FK523은 타크롤리무스 C21 위치의 메틸 유사체 (methyl analog)이며, FK525는 타크롤리무스의 프롤릴 유사체 (prolyl analog)이다.
타크롤리무스는 스트렙토마이세스 츠쿠바엔시스(Streptomyces tsukubaensis) 9993(미국 특허 제4,894,366호), 스트렙토마이세스속 (Streptomyces sp.) ATCC 55098, 스트렙토마이세스속(Streptomyces sp.) ATCC 53770, 스트렙토마이세스 클라불리제루스(Streptomyces clavuligerus) CKD1119 (대한민국 특허 10-0485877), 스트렙토마이세스 카나마이세티쿠스(Streptomyces kanamyceticus) KCC S-043 (KCTC 9225) 등의 균주에서 생산되는 것으로 보고되었으며(Muramatsu H.등, 2005), FK506 과 구조적으로 유사체인 FK520 또한 스트렙토마이세스 하이그로스코피쿠스 아속 아스코마이세티쿠스(Streptomyces hygroscopicus subsp. ascomyceticus) ATCC 14891, 스트렙토마이세스 하이그로스코피쿠스 아속 야쿠시마엔시스(Streptomyces hygroscopicus subsp. yakusimaensis) 7238과 스트렙토마이세스 츠쿠바엔시스(Streptomyces tsukubaensis) 993 등이 생산하는 것으로 보고되었다. 또한, 라파마이신은 스트렙토마이세스 하이그로스코피쿠스 아속 하이그로스코피쿠스 (Streptomyces hygroscopicus subsp. hygroscopicus) ATCC 29253이 생산하는 것으로 보고되었다.
삼원환 화합물(Tricyclocompounds)은 폴리케타이드(polyketide)와 비 리보좀유래 펩타이드 (nonribosomal peptide) 혼합형(hybrid) 화합물군에 속한다. 이들의 화학구조는 2개의 탄소유닛(carbon unit)이 축합되어 형성되는 폴리케타이드에 사이크로헥실(cyclohexyl) 구조와 비 단백질성 아미노산 (unusual amino acid)인 피페콜린산(pipecolic acid) [FK525의 경우 프롤린(proline)]이 연결되어 형성된 마크롤라이드(macrolide)계 화합물이다. 이들 화합물은 통상적으로 화학적으로 합성이 매우 힘들고, 야생형 생산균주에 의해 생산되는 양은 매우 적다. 그러므로, 이들 화합물의 생합성 기구는 이들 화합물의 구조 변경에 의한 신규물질 창출과 생산력 증대를 위한 수단으로 이용될 수 있다.
미생물이 생산하는 마크롤라이드계 물질의 생합성 기구는 다수의 큰 단백질들의 복합체 (multiple large proteins complex)로 구성되어 있는 거대효소(megasynthase)이다. 특히 폴리케타이드 부위 생합성은 아실코에이(acyl-CoA)의 반복적 축합(claisen condensation)에 의해 이루어지며, 이들 물질의 생합성을 담당하는 유전자에 의해 암호화되어 있는 효소는 모듈 (module) 형태의 단위로 구성되어 순차적으로 작용하는 것으로 알려져 있다. 이를 소위 모듈 제1형 폴리케타이드 합성효소[modular type I polyketide synthase(PKS)]로 분류한다.
모듈 제1형 폴리케타이드 합성효소(modular type I PKS)는 각 사슬 길이를 연장(elongation)하고 변형(modification)하는 촉매부위(catalytic domain)가 모듈이라는 일련의 세트로 구성되어 있다. 하나의 모듈이 한 사이클씩 진행함에 따라 골격을 구성하는 탄소가 두개씩 커지게 된다. 전형적인 모듈 제1형 폴리케타이드 합성효소는 효소활성복합체 (multienzyme system)이며, 시작 모듈 (loading module), 다수의 확장 모듈 (multiple extender modules) 그리고 해리 모듈 (releasing module)로 구성된 것이 전형적인 모습이다.
시작 모듈은 일반적으로 아세틸(acetyl)혹은 프로피오닐(propionyl)기를 아실코엔자임-A (acyl-CoA)를 기질로 사용하지만 독특한 화학구조체를 사용하는 경우도 빈번하다. 확장 모듈은 기본적으로 케토기 합성효소(Ketosynthase; KS), 아실기 전이효소(Acyltransferase; AT), 아실기 운반 단백질(Acyl carrier protein; ACP)의 세 개의 효소도메인(enzymatic domains) 으로 구성되어 있다. 여기에 부가적으로 베타탄소 (beta-carbon)의 변형(modification)에 관여하는 효소들 즉, 케토환원효소(ketoreductase; KR), 탈수소효소(dehydratase; DH), 에놀기 환원효소(enoyl reductase; ER) 등이 첨가되어 모듈이 구성되기도 한다. 한 번의 모듈의 작용으로 아실 코에이 잔기가 첨가되는데 아실기 전이효소(AT)는 아실 잔기(acyl moiety)를 해당하는 아실기 운반 단백질(ACP)로 전달하여 아실-ACP를 생성하게 하고 케토기 합성효소(KS)는 앞의 모듈에 의해 첨가된 분자에 생성된 아실-ACP의 아실기를 클라이젠 축합(claisen condensation)을 통해 탄소-탄소 결합을 하도록 하여 점차적으로 탄소 수를 증가시킨다. 즉 이들 세트가 한 번 작용하면 하나의 아실 잔기가 첨가되어 골격 탄소사슬의 탄소수가 2개씩 증가될 수 있다. 이 과정에서 케토환원효소, 탈수소효소, 그리고 에놀기 환원효소가 차례로 작용하여 베타 탄소 위치의 케토기가 알콜기로, 알콜기가 이중결합으로, 이중결합이 포화 단일결합(saturated single bond)으로 변형되기도 한다.
상기와 같이 폴리케타이드와 같은 화합물의 생합성 유전자 기구는 일반적으로 담당하고 있는 물질의 구조를 반영하여 구성되어 있다. 생합성기구는 연속공정 시스템으로 구성되어 있으며, 모듈 변형과 같은 연속공정 시스템의 변형으로 종종 원래 담당하고 있는 물질과 다른 구조의 물질이 생산에 응용되기도 한다. 그러므로, 모듈로 구성된 조립라인의 의도적인 변형은 새로운 구조의 물질을 창출할 수 있는 중요한 방편이 될 수 있다. 즉, 생합성 유전자의 부품라인이라고 할 수 있는 모듈의 변형은 바로 새로운 구조의 물질 창출을 의미하게 된다. 이러한 원리에 착안하여, 특정 모듈을 담당하고 있는 유전자를 체계적, 효율적으로 변형, 결실 또는 치환하여 신규의 다양한 물질의 창출을 시도하고자 하는 기술이 조합생합성(combinatorial biosynthesis)이다. 이러한 기술을 적용하기 위해 근본적으로 생합성 유전자를 확보하여야 한다.
최근에는 몇 가지 삼원환화합물의 생합성을 담당하는 유전자군이 밝혀졌다.
가장 먼저 라파마이신 생합성 유전자와 그 단백질은 스트렙토마이세스 하이그로스코피쿠스 아속 하이그로스코피쿠스 (Streptomyces hygroscopicus subsp. hygroscopicus) ATCC 29253으로부터 클로닝되었다(Schwecke T. 등, 1995).
또한, 스트렙토마이세스 속(Streptomyces sp.) MA6548로부터 타크롤리무스 생합성 유전자가 클로닝되었다(Motamedi H.등, 1998 와 Motamedi H.등, 1997). 이들이 밝힌 유전자는 3개의 폴리케타이드 합성효소(PKS) 유전자 즉 fkbA, fkbB, fkbC이며 이와 더불어, fkbA와 동일한 방향으로 그 상류(upstream)에 fkbO, fkbP가 존재하며 fkbC의 상류에 fkbL이 존재하고, fkbA 의 하류(down stream)에 fkbD 와 fkbM이 전체 약 63kb에 걸쳐 존재하고 있음을 밝혔다.
또한, 아스코마이신 생산균주인 스트렙토마이세스 하이그로스코피쿠스 아속 아스코마이세티쿠스(Streptomyces hygroscopicus subsp. ascomyceticus) ATCC 14891로부터 아스코마이신 생합성 유전자군이 클로닝되었고(Wu, K. L. 등, 2000), 전체 약 80kb의 연결 유전자 서열을 분석하여 아스코마이신 생합성에 관련될 것으로 추정되는 fkbA,B,C,P,D,M,O,L,N,Q,S,K,J,I,H,G,F,E,R1,R2,U,W 22개의 유전자 정보를 확인하였다.
타크롤리무스 생합성 유전자와 아스코마이신 생합성 유전자의 구성은 매우 유사하였다. 특히, 폴리케타이드 합성효소를 구성하고 있는 도메인 구성은 아스코마이신 생합성 폴리케타이드 합성효소의 모듈 3과 모듈 8에 존재하는 탈수소효소(DH) 도메인이 타크롤리무스 생합성 유전자에는 존재하지 아니한다는 보고 이외에는 동일하였다. 타크롤리무스 생합성 기구는 그 외 FkbO(oxidase) FkbP(peptide synthase), FkbD(p450 hydroxylase), FkbM(O-methyl transferase) 그리고 FkbL(lysine cyclodeaminase)이 공통적으로 발견되었다. 그러나, 타크롤리무스 생합성 유전자군의 불완전한 확보로 인해 아스코마이신(FK520)에 존재하는 메톡시말로닐 ACP(methoxymalonyl ACP)의 합성을 담당할 것으로 추정되는 FkbG,H,I,J,K를 포함하여 특이적인 전사조절인자인 FkbN 을 담당하는 유전자 등의 존재 유무는 밝혀지지 않았다.
아스코마이신 생산균주인 스트렙토마이세스 하이그로스코피쿠스 아속 아스코마이세티쿠스(Streptomyces hygroscopicus subsp. ascomyceticus) ATCC 14891의 발효배양체에서 타크롤리무스, 다이하이드로타크롤리무스 등의 C21 위치에 탄소가 4개 부착된 유도체가 발견된 보고가 없다. 그러나, 타크롤리무스 생산균주인 스트렙토마이세스 츠쿠바엔시스(Streptomyces tsukubaensis) 993의 경우 아스코마이신 및 다이하이드로타크롤리무스, FK523 등 C21 위치의 유사체가 생산되는 것으로 보고되었다(미국 특허 4,894,366). 이러한 유사체 발효산물 의 존재로부터 타크롤리무스 생산균주 생합성 유전자의 구성이 아스코마이신 생산균주 생합성 유전자 구성과는 차이가 있음을 유추해 볼 수 있다. 즉, 타크롤리무스 생산균주의 경우 C21 위치 생합성 유전자를 담당하는 또 다른 유전자가 아스코마이신 생합성 유전자에 부가하여 존재할 가능성이 높은 것이다. 또한 타크롤리무스와 아스코마이신 등의 삼원환 화합물 생합성 조절에 관여하는 또 다른 유전자는 타크롤리무스 및 기타 삼원환 화합물의 생산 증대 혹은 다양한 유도체 창출이 가능하도록 이용할 수 있을 것이다.
본 발명의 목적은 면역억제제로 사용되고 있는 타크롤리무스와 그 유연물질의 생합성에 직접적으로 관계하는 핵산 서열과 그 서열에 담겨 있는 폴리펩타이드 서열 정보를 제공하는 것이다.
본 발명자들은 타크롤리무스 생산균주들로부터 생합성 유전자를 완전하게 확보하고 유전자의 기능을 규명하고 이용성을 확인하였다. 본 발명은 기존에 불완전하게 규명된 타크롤리무스 생합성 기구를 담당하고 있는 타크롤리무스 생합성 유전자군을 더욱 확대하여 아스코마이신 생합성 유전자에는 존재하지 않으며 타크롤리무스 생합성 유전자에만 존재하는 유전자를 확보하였다. 즉, 기존 타크롤리무스 생합성 유전자군에서 밝혀진 FkbA,B,C 및 FkbO,P,D,M,L을 포함하는 완전한 타크롤리무스 생합성기구를 담당하는 유전자군을 확보하여 핵산서열을 밝혔으며, 그 핵산 서열이 담고 있는 유전자와 그 유전자로부터 생산되는 폴리펩타이드와 타크롤리무스 및 그 유사체를 포함하는 삼원환 화합물들의 생합성 연관성을 규명하고 그 산업적 응용성을 확인하였다.
본 발명은 서열번호 1, 54 또는 93과 동일하거나 85% 이상의 동일성을 나타내는 서열 또는 상기 서열에 상보적인 서열로 표시되는 타크롤리무스 생합성 유전 자 클러스터를 제공한다.
본 발명은 서열번호 3, 56 또는 95와 동일하거나 80% 이상의 동일성을 나타내는 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자를 제공한다.
본 발명은 서열번호 2, 55 또는 94와 동일하거나 80% 이상의 동일성을 나타내는 서열로 표시되는 폴리케타이드 합성효소를 제공한다.
본 발명은 서열번호 5, 58 또는 97과 동일하거나 80% 이상의 동일성을 나타내는 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자를 제공한다.
본 발명은 서열번호 4, 57 또는 96과 동일하거나 80% 이상의 동일성을 나타내는 서열로 표시되는 폴리케타이드 합성효소를 제공한다.
본 발명은 서열번호 7, 60 또는 99와 동일하거나 90% 이상의 동일성을 나타내는 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자를 제공한다.
본 발명은 서열번호 6, 59 또는 98과 동일하거나 90% 이상의 동일성을 나타내는 서열로 표시되는 폴리케타이드 합성효소를 제공한다.
본 발명은 서열번호 9, 62 또는 101과 동일하거나 90% 이상의 동일성을 나타내는 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자를 제공한다.
본 발명은 서열번호 8, 61 또는 100과 동일하거나 90% 이상의 동일성을 나타 내는 서열로 표시되는 폴리케타이드 합성효소를 제공한다.
본 발명은 청구항 1의 타크롤리무스 생합성 유전자 클러스터 중 fkbD 유전자 코딩 영역을 결손시키거나 불활성화시킨 돌연변이체를 배양하여 9-디옥소-31-O-데스메틸-타크롤리무스, 9-디옥소-31-O-데스메틸-아스코마이신 및 9-디옥소-31-O-데스메틸-36,37-다이하이드로-타크롤리무스 중 선택된 1종 이상을 생산하는 방법을 제공한다.
본 발명은 청구항 1의 타크롤리무스 생합성 유전자 클러스터 중 fkbM 유전자 코딩 영역을 결손시키거나 불활성화시킨 돌연변이체를 배양하여 31-O-데스메틸-타크롤리무스, 31-O-데스메틸-아스코마이신 및 31-O-데스메틸-36,37-다이하이드로-타크롤리무스 중 선택된 1종 이상을 생산하는 방법을 제공한다.
본 발명에서 타크롤리무스 생합성 유전자군은 3가지 타크롤리무스 생산균주 스트렙토마이세스속(Streptomyces sp.) ATCC 55098, 스트렙토마이세스 카나마이세티쿠스(Streptomyces kanamyceticus) KCTC 9225, 스트렙토마이세스속(Streptomyces sp.) KCTC 11604BP(이하, 본 발명의 상세한 설명 및 서열목록에서 "Streptomyces sp. GT1005" 또는 "GT1005"와 혼용함)로부터 확보하였다. 각 균주로부터 타크롤리무스 생합성 유전자군의 연속적인 핵산 서열을 확보하고(서열번호 1, 54, 93), 이들 연속적인 핵산서열로부터 유전자 (서열번호 3,5,7,9,11,13,15,17,19,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,51,53, 56,58,60,62,64,66,68,70,72,74,76,78,80,82,84,86,88,90,92,95,97,99,101,103,105,107,109,111,113,115,117,119,121,123,125,127,129,131)를 예측하고, 폴리펩타이드 서열(서열번호 2,4,6,8,10,12,14,16,18,20,22,24,26,28,30, 32,34,36,38,40,42,44,46,48,50,52,55,57,59,61,63,65,67,69,71,73,75,77,79,81,83,85,87,91,94,96,98,100,102,104,106,108,110,112,114,116,118,120,122,124,126,128,130)을 확인하였으며, 이들 유전자의 돌연변이체들을 작제하여 타크롤리무스 및 그 유사체 등의 생합성 연관관계를 규명하였다. 이러한 발명으로 타크롤리무스 생합성 유전자군에서 공통적으로 발견되는 유전자 19개(서열번호 3,5,7,9,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,56,58,60,62,64, 66,68,70,72,74,76,78,80,82,84,86,88,90,92,95,97,99,101,103,105,107,109,111,113,115,117,119,121,123,125,127,129,131)를 확인하였다(도 2).
본 발명자들은 특히 이들 유전자 중에 tcsA,B,C,D의 유전자 및 이들 유전자가 담당하고 있는 폴리펩타이드(서열번호 2,3,4,5,6,7,8,9,55,56,57,58,59, 60,61,62,94,95,96, 97,98,99,100,101)가 타크롤리무스와 그 유연물질의 C-21 위치의 곁사슬(알릴-말로닐 유도체)의 합성에 관여함을 밝혔다. 그러므로 이들 유전자가 신규한 물질의 창출 혹은 타크롤리무스 및/또는 그 유연물질의 생산성의 증대 및 불순물 감소를 통한 경제적인 생산에 활용될 수 있을 것이다.
또한, 본 발명자들은 fkbD와 fkbM (서열번호 42,43,44,45)의 돌연변이 방법으로 9-디옥소-31-O-데스메틸-타크롤리무스(아스코마이신){9-deoxo-31-O-desmethyl-tacrolimus(ascomycin)}와 31-O-데스메틸-타크롤리무스(아스코마이신){31-O-desmethyl-tacrolimus(ascomycin)}을 고생산할 수 있음을 확인하였다.
본 발명으로 타크롤리무스(FK506), 아스코마이신(FK520), 다이하이드로타크롤리무스, 프롤릴타크롤리무스(FK525), FK523(L-683795), L-687819, 9-디옥소-31-O-데스메틸-타크롤리무스, 9-디옥소-31-O-데스메틸-아스코마이신, 9-디옥소-타크롤리무스, 9-디옥소-아스코마이신, 9-하이드록시-9-디옥소-타크롤리무스, 9-디옥소-36,37-다이하이드로-타크롤리무스, 31-O-데스메틸-타크롤리무스, 31-O-데스메틸-아스코마이신, 31-O-데스메틸-36,37-다이하이드로-타크롤리무스, 9-디옥소-31-O-데스메틸-36,37-다이하이드로-타크롤리무스, 프롤릴-다이하이드로-타크롤리무스, 라파마이신, 메리다마이신 및 36-케토-메리다마이신 생합성에 필요한 유전자를 확보하였으며, 이들 물질의 산업적 생산 및 다른 신규한 구조의 화합물 창조를 위한 구조변형 등에 응용할 수 있다.
본 발명의 예시에서 제시된 fkbM, fkbD 돌연변이체의 작제방법에 의해 합리적으로 만들어질 수 있는 돌연변이체는 9-디옥소-31-O-디메틸-타크롤리무스, 9-디옥소-31-O-디메틸-아스코마이신, 9-디옥소-31-O-디메틸-36,37-다이하이드로-타크롤리무스, 31-O-디메틸-타크롤리무스, 31-O-디메틸-아스코마이신 및 31-O-디메틸-36,37-다이하이드로-타크롤리무스의 생산성을 높일 수 있어 야생형에서 소량으로 생산되는 상기 타크롤리무스 변형물질의 고생산에 응용될 수 있다.
본 발명으로 확보한 TcsA,TcsB,TcsC,TcsD 유전자 및 그 유전자가 코딩하고 있는 단백질은 타크롤리무스 21 위치의 곁가지 (알릴-말로닐 유도체)의 생산 혹은 변형에 직접, 발현 혹은 돌연변이체 작제로 이용될 수 있으며 이를 이용한 전체 폴 리케타이드 물질의 구조 변형 또는 불순물 감소에 응용될 수 있다.
이러한 발명의 구체적인 내용을 아래 실시예에서 상세히 설명하고자 하며, 하기 실시예에서 사용한 균주, 벡터, 프로모터, 개시체, PCR방법, 제한효소 및 제한효소 부위, 기타 핵산의 클로닝과 서열 분석에 사용한 효소, 시약 및 기기 등의 재료 및 방법, 돌연변이 방법은 본 발명의 실시방법을 예를 들어 상세히 설명하고자 하는 것이다. 그러나, 아래 실시예의 기재가 본 발명의 권리 범위를 구체적으로 제한하는 것은 아니다.
<실시예 1> 균주 및 발효
본 발명에서는 타크롤리무스를 생산하는 균주들로부터 생합성 유전자를 확보하였다. 본 발명에 사용된 방선균은 타크롤리무스의 생산이 보고된 스트렙토마이세스 카나마이세티쿠스(Streptomyces kanamyceticus) KCTC 9225 (Muramatsu H. 등, 2005)와 스트렙토마이세스속(Streptomyces sp.) KCTC 11604BP 및 스트렙토마이세스속(Streptomyces sp.) ATCC 55098이다.
상기 기록한 방선균속뿐만 아니라, 하기 본 발명에 기재된 상기 균주의 돌연변이체 및 형질전환체를 이용한 타크롤리무스 또는 그 유사체의 발효 배양은 아래 조건으로 수행하였다.
스트렙토마이세스속 균주를 500㎖ 엘렌마이어 삼각 플라스크에 들어있는 30 ㎖ GT-TA-1 배지[1% 수용성 전분, 0.7% 글리세롤, 0.3% 박토펩톤, 0.3% 효모추출물, 0.5% 소이톤펩톤, 0.05% AZ-20R(antifoam), pH 6.8]에 28℃, 240rpm의 조건에서 하루 동안 배양하여 활성화시킨 후, 활성화된 종배양 균주를 3ℓ 엘렌마이어 삼각플라스크에 들어있는 150㎖의 GT-TA-2 배지[1% 산화 전분, 1% 글리세롤, 2% 소이빈 밀, 0.2% CaCO3, 0.5% CSL, 0.05% AZ-20R(antifoam), pH 6.5]에 접종, 동일 조건에서 하루 동안 배양을 실시하였다. GT-TA-2 배지에서 배양된 배양액을 5ℓ 발효장치에 들어있는 2.7ℓ의 GT-TA-4 배지 [7% 산화 전분, 1.7% 효모 분말, 0.5% 소이빈 밀, 0.1% (NH4)2SO4, 0.1% CaCO3, 0.05% AZ-20R(antifoam), pH 8.5]에 최종 배양액 부피의 10%의 양을 접종하여 28℃의 온도에서 6일 동안 1.5vvm의 통기 조건에서 600~900rpm으로 배양을 실시하였다. 고농도로 배양할 필요가 있는 경우 5% HP-20 레진을 GT-TA-4 배지에 첨가하여 살균 후 사용하였다.
<실시예 2> 타크롤리무스 및 유연물질 분석
발효 배양된 배양액으로부터 회수된 배양액 혹은 HP-20 레진으로부터 75% 아세톤으로 대사물질을 추출하였다. 추출된 대사물질은 표 1과 같은 HPLC 조건 하에 분석하였다.
항목 | 조건 내용 |
칼럼 | Hypersil GOLD C18 analytical column(Thermo) |
칼럼온도 | 55℃ |
흡수파장 | 210㎚ |
이동상 | 50% 아세토나이트릴(Acetonitrile) |
유속 | 1㎖/min |
시료 주입량 | 20㎕ |
타크롤리무스 및 그 유연물질을 동정하기 위해 LC-MS/MS를 수행하였다. LC-MS/MS를 위해 아래와 같이 HLB 카트리지를 이용하여 시료를 부분정제하였다. 배양액에 아세토니트릴을 동일 부피로 혼합하고 30분간 추출한 후 물을 부가하여 최종적으로 아세토니트릴이 25%가 되도록 하였다. 이를 HLB 카트리지(OASIS HLC cartridge, 1㎖)에 통과하고 이후에 2배 용량의 30% 아세토니트릴로 미흡착 물질을 씻어내었다. 그 후 40, 50, 60, 70% 아세토니트릴로 1배량으로 용리하였다. 단계별 용리액 중 50% 아세토니트릴 용리액을 주분획으로 사용하여 표 2와 같은 LC-MS 조건으로 질량분석을 진행하였다.
조건 항목 | 조건 내용 |
칼럼 | YMC Ultra C18(5*2㎜, 2㎛) |
이동상 | 50 -100% gradient of acetonitrile |
유속 | 1㎖/min |
기기 | Shimadzu LCMS-IT-TOF |
이온화 | ESI, positive |
단편화세기 | 100V |
스캔범위 | 200~1000 m/z |
시료주입량 | 1~5㎕ |
스트렙토마이세스 카나마이세티쿠스 KCTC 9225와 스트렙토마이세스속 KCTC 11604BP의 발효배양체에서 C18 HPLC 수행 조건에서 약 19.9분에 HR-MS (M+Na)+ m/z 826.4730으로 타크롤리무스(FK506)(Mr. 803.4820)가 확인되었으며, 타크롤리무스 피크 전후로 여러 유사체들이 존재하였다. 약 18.1분에 m/z 814.4661의 아스코마이신(FK520)(Mr. 791.4819), 16.7분에 m/z 812.455의 FK525(Mr. 789.4663), 28.1분에 m/z 818.4826의 다이하이드로타크롤리무스(dihydro tacrolimus; DH-FK506) (Mr. 805.4976)가 검출되었다. 그러나, 미국 종균협회(ATCC)에서 구입한 스트렙토마이세스속 ATCC 55098의 실시예 1의 방법으로 배양한 배양체에서는 타크롤리무스를 확인할 수 없었다.
하기 실시예에서 만들어진 여러 돌연변이체 및 형질전환체들도 실시예 1과 같이 배양하고, 표 1과 표 2에 준하여 HPLC 및 LC-MS 분석을 실시하였다.
<실시예 3> 항진균 활성 측정
항진균 활성 측정을 위해 아스퍼질러스 나이거(Aspergillus niger) ATCC 9642를 피검균으로 사용하였다. Potato Dextrose Agar 배지(0.4% 감자전분, 2% 덱스트로스, 1.5% 한천)을 멸균하여 40~50℃로 식힌 후, 피검균을 접종하여 피검균 배지를 준비하였다. 야생주 및 돌연변이주들의 배양액으로부터 확보한 항균활성 측정을 위한 대상 추출액을 페이퍼 디스크(ADVANTEC, Toyo Roshi Kaisha, Ltd.)에 묻힌 후 미리 준비한 피검균 배지에 올려 28℃에서 이틀 동안 배양하고, 저해활성환(clear zone)의 크기를 측정하여 항균력을 확인하였다.
<실시예 4> 생합성 유전자 확보
상기 실시예 1에 명시된 3종의 균주로부터 생합성 유전자를 확보하였다. 먼저 각 균주의 포스미드(fosmid) 라이브러리를 제작하고 포스미드 라이브러리는 Kieser 등이 제시한 방법(Kieser T. 등, 2000)을 이용하여 크로모좀을 분리하여 사용하였고, 포스미드 라이브러리 제작은 Epicentre사로부터 키트를 구입하여 제작사가 지시한 방법에 따라 제작하였다. 각 균주로부터 제작된 약 1,500개의 포스미드 말단을 Sanger의 다이디옥시방법(dideoxy methods)으로 ABI-3730xl autosequencer를 사용하여 0.02/10kb 이상의 정확도로 서열을 분석하여 염기서열정보를 확보하였다. 이렇게 구성된 정보를 이용하여 폴리케타이드 합성효소 유전자 정보가 함유된 포스미드 클론을 찾았으며, 이들을 숏건 서열분석(shotgun sequencing) 방법을 이용하여 염기서열 분석하였다. 각 분석된 reads 정보를 Phred-Phrap™(University of washington, Seatle, U.S.A) 프로그램을 이용하여 연결(assemble)하여 최종적으로 완전히 연결된 타크롤리무스(FK506) 생합성 유전자를 확보할 수 있었다. 스트렙토마이세스속 KCTC 11604BP는 Fos1004F01 (1-40366), Fos1005D02 (39116-80661), Fos1006D05 (58172-97743)을 분석하여 전체 약 97kb의 연결정보(서열번호 1)를 확보하였다. 스트렙토마이세스 카나마이세티쿠스 KCTC 9225 유래의 생합성 유전자는 Fos1006G02 (1-35521), Fos1012A09 (31026-67758), Fos1004E04 (41430-85253), Fos1010E10 (76978-111990)을 분석하여 전체 약 109kb의 연결정보(서열번호 54)를 확보하였다. 또, 스트렙토마이세스속 ATCC 55098 유래의 생합성 유전자는 Fos1011B11 (142-41780), Fos1010H09 (9845-44813), Fos1012B03 (27400-72808), FOS1001F05 (59902-95981)의 염기서열을 완전히 분석하여 전체 약 99kb의 연결정보(서열번호 93)를 확보하였다. 기존에 알려진 타크롤리무스 생합성 유전자는 폴리케타이드 합성효소를 중심으로 수개의 유전자만이 확보, 분석되어 완전한 타크롤리무스 생합성기구 전체 구성의 이해와 산업적 활용에 부족하였으나, 본 발명을 통해 전체 생합성 유전자가 포함된 충분한 크기의 유전자를 확보하고, 이를 체계적으로 분석할 수 있었다(도 2).
<실시예 5> 생합성 유전자 정보 분석
각 균주로부터 확보된 염기서열을 Glimmer program으로 orf(open reading frame)를 예측하고 각 기능을 BLAST-2.2.21로 비교하여 예측하였다. 스트렙토마이세스속 KCTC 11604BP 유래 유전자의 경우 전체 약 44개의 orf들을 예측할 수 있었으며(표 3), 스트렙토마이세스 카나마이세티쿠스 KCTC 9225 유래의 경우 약 70개의 orf를 예측하였고, 스트렙토마이세스속 ATCC 55098의 경우 약 56개의 orf를 예측하였다.
이들 유전자에게서 공통적으로 발견되는 유전자는 모두 19개였다(서열번호 3,5,7,9,21,23,25,27,29,31,33,35,37,39,41,43,45,47,49,56,58,60,62,64,66, 68,70,72,74,76,78,80,82,84,86,88,90,92,95,97,99,101,103,105,107,109,111,113,115,117,119,121,123,125,127,129,131). 본 발명에서는 아스코마이신 생합성 유전자와 높은 유사도(유사도 70% 이상)를 나타내는 경우 Wu K.등(2000)에서 명명한 유전자명에 준하여 명명하였으며, 필요시 유전자의 유래를 표시하였다. 그 외 유전자들은 tcs (tacrolimus synthase)로 명명하였다.
공통적으로 발견되는 19개 유전자 중 15개 유전자는 아스코마이신 생합성 유전자에서 발견되는 것과 유사하였다. 즉, 3개의 주요 폴리케타이드 합성효소를 코딩하고 있는 유전자들(fkbA,B,C), 메톡시말로닐(methoxymalonyl) ACP 합성관련 유전자들(fkbG,H,I,J,K), 피페콜산(pipecolate) 생합성 유전자(fkbL), 변형 관련 추정 유전자들(fkbM,D,O), 조절유전자(fkbN), 비 리보솜 펩타이드 합성효소 (fkbP), 그리고 타입 Ⅱ 티오에스터라제(thioesterase; TE) 유전자(fkbQ)는 아스코마이신 생합성 유전자군에서 보고되었다.
새로운 4개의 유전자 (tcsA,B,C,D )와 그 폴리펩타이드는 타크롤리무스 생합성에 특이적인 것으로 추정되며, 본 발명에 이하여 처음으로 확인된 유전자 및 산물이다 (서열번호 2,3,4,5,6,7,8,9,55,56,57,58,59,60,61,62,94,95,96, 97,98,99,100,101).
<실시예 6> 주요 폴리케타이드 합성효소의 효소활성 도메인 분석
본 발명에서 확보한 생합성 유전자군이 타크롤리무스와 그 유연물질의 생합성을 온전히 담당할 수 있는지를 확인하기 위해 스트렙토마이세스속 KCTC 11604BP 와 스트렙토마이세스 카나마이세티쿠스 KCTC 9225의 생합성 유전자의 주요 폴리케타이드 합성효소(PKS)를 중심으로 효소활성에 필수적인 도메인 구성을 분석하였다 (도 3).
-ACP(Acyl carrier protein) 도메인
폴리케타이드 합성효소 상의 10개 모듈 내의 ACP와 TcsA의 ACP 도메인, 그리고 FkbJ까지 모두 4'-포스포팬테티엔(4'-phosphopantetheine) 부착에 필수적인 세린 잔기가 잘 보존되어 있다(Florova G. 등, 2002).
-KS(Ketosynthase) 도메인
폴리케타이드 합성효소 상의 10개 KS 도메인에 탈카복시화(decarboxylation)와 아실기 전이에 필수적인 시스테인, 히스티딘, 라이신 아미노산이 잘 보존되어 있다 (Dreier J. 와 Khosla C., 2000).
-AT(Acyltransferase) 도메인
폴리케타이드 합성효소 상의 10개 AT 도메인에 Gx(H)SxG 의 호중 엘보(nucleophile elbow)를 구성하는 아미노산 잔기가 잘 보존되어 있으며, 또한 촉매에 필요한 기타 아미노산들이 잘 보존되어 있다 (Keatinge-Clay A. T. 등, 2003).
-KR(ketoreductase) 도메인
모듈 1,2,3,5,6,7,8,9에 각 한 개씩 모두 8개의 KR 도메인이 존재하고 있다. NADPH 또는 NADH 결합에 필요한 부분과 로자만 폴드(Rossaman fold) 구성에 중심적인 역할을 하는 타이로신(Tyr)이 보존되어 있으며(Reid, R. 등 2003), 또한 LDD 모티프가 잘 보존되어 있다 (Caffrey, P., 2003). 이는 B-타입 KRs이 알콜 입체화학구조를 가지는 것과 부합하는 결과이다.
-DH(Dehydrogenase) 도메인
모듈 1에서 9까지 DH 도메인이 존재하였다. 모듈 3과 8에 존재하는 DH 도메인 유사체 이외의 7개의 DH 도메인은 효소활성부위인 HxxxGxxxP 모티프와 효소 활성에 필수적인 부위인 히스티딘과 프롤린이 잘 보존되어 있다(Joshi, A. K., and Smith, S., 1993).
그러나, 모듈 8번 DH의 경우 활성부위가 완전히 소실되어 있으며, 스트렙토마이세스 카나마이세티쿠스 KCTC 9225 유래 모듈 3의 DH 도메인은 활성부위를 구성하는 아미노산 잔기인 프롤린이 세린으로 변경되어 있어 활성을 갖기는 어려운 것으로 판단된다.
베타 케토 산화(Beta keto oxidation)에 관여하는 DH의 경우 모듈 구성상 모듈 2와 모듈 4의 DH는 요구되지 않으나 활성에 필요한 아미노산 잔기가 잘 보존되어 있다.
-ER(enoyl reductase) 도메인
ER 도메인은 시작 모듈(loading module)과 모듈 6,7,9에 ER 도메인이 존재하고 있으며 모두 ER 기능에 중요한 NADPH 결합 부위를 구성하는 LxHxxxGVG가 잘 보존되어 있다(Witkowski, A. 등, 1991,Amy C. M. 등, 1989).
-TE(thioesterase) 도메인
FkbQ는 촉매 트리아드(catalytic triad)를 구성하는 Ser, His, Asp과 호중 엘보(nucleophile elbow)를 구성하는 GxSxG가 보존되어 있다(Bruner, S. D. 등, 2002).
-스트렙토마이세스속 ATCC 55098 유래의 폴리케타이드 합성효소
스토렙토마이세스속 ATCC 55098 유전자의 경우 폴리케타이드 합성효소의 일부 모듈이 소실되어 완전한 형태가 아니었다. 이로 미루어 스트렙토마이세스 카나마이세티쿠스 KCTC 9225 및 스토렙토마이세스속 KCTC 11604BP균주 유래의 생합성 유전자와 달리 스토렙토마이세스속 ATCC 55098 유래의 생합성 유전자는 타크롤리무스 및 그 구조 유사체의 생합성에 불충분할 것으로 추정되었으며, 균주의 보관 중 돌연변이가 있었을 것으로 추정된다(도 2).
<실시예 7> 폴리케타이드 합성효소 이외의 유전자의 정보 분석
-전사후 변형 유전자
Fkb
O,
Fkb
M,
Fkb
D
FkbM은 31-O-메틸 전이효소로 FkbM-sk (sk는 Streptomyces kanamyceticus KCTC 9225 유래를 의미)는 FkbM-asco (asco는 Streptomyces hygroscopicus subsp. ascomyceticus ATCC 14891 유래를 의미)와 82%, RapI과 71%의 유사도를 보이고 있다. Shikimate에서 유래된 4,5-DHCHC(dihydroxylcyclohex-1-enecarboxylic acid) 개시 유닛(starter unit)의 O-메틸화를 촉매하는 효소로 추정된다.
FkbD는 C9-p450 하이드록실레이즈(hydroxylase)이다. FkbD-sk는 FkbD-asco와 88%, RapJ와 76%, MerE와 35%의 유사도를 보였다. 이 유전자는 C9 Oxo FK506의 하이드록실화를 담당하여 C9-OH FK506을 생산하는 것으로 추정되고 있다. 그러나, 최근의 연구(Moss S. J. 등, 2004)를 볼 때 C9-옥소 프리-라파마이신(C9-oxo pre-rapamycin)으로부터 직접 RapJ에 의해 C9 케토폼(keto form)인 프리-라파마이신(pre-rapamycin)이 합성될 수 있음이 보고되었다. 이로 미루어 RapK의 유사체인 FkbD도 C9-케토폼인 타크롤리무스를 C9-옥소폼으로부터 직접 생성하는 것을 담당할 것으로 추정된다.
FkbO는 산화효소이다. FkbO-sk는 FkbO-asco와 83%, RapK와 71%의 유사도를 보였다. FkbO의 기능은 불분명하다. C9 위치의 수산화기 산화에 관여할 것으로 추정하였으나, 라파마이신과 FK506/FK520 모두 C9 케토기를 형성하기 위해서는 C9-OH기의 산화 단계가 필요하다. C9-OH 타크롤리무스는 발효 부산물(by- product)로 발견되으로 C9-OH 산화효소 역할을 할 것으로 추정할 수 있다. 그러나, 라파마이신 생합성 유전자기구에 존재하는 FkbO의 유사체인 RapK의 연구결과는 C-9 산화효소로의 역할보다 개시 유닛인 DHCHC의 생합성 혹은 그의 조절 역할을 할 것으로 추정하기도 한다(Gregory M. A. 등, 2005).
-전사조절 유전자,
fkbN
S. kanamyceticus KCTC 9225, S. sp. ATCC 55098, S. sp. KCTC 11604BP, 그리고, S. hygroscopicus subsp. ascomyceticus ATCC 14891 모두에서 발견되는 조절 유전자는 LuxR 패밀리 전사조절인자를 코딩하는 fkbN 유사체였다. fkbN 유사체는 fkbQ 와 fkbN 사이에 존재하고 있었으며 모두 fkbM 유사체와는 역방향 그리고, fkbQ 유사체와는 동일한 방향으로 유전자가 배치되어 있었다.
-메톡시말로닐 ACP 합성 유전자
일반적으로 폴리케타이드 부위는 말로닐-CoA와 메틸말로닐-CoA가 가장 흔히 사용되는 전구체이다. 그러나 타크롤리무스 및 아스코마이신은 독특한 전구체가 사용되는데 이는 메톡시말로닐(methoxylmalonyl)-ACP이다. 이의 합성을 위해 현재까지 5개의 유전자 즉 fkbG,H,I,J,K가 관여하는 것으로 추정하고 있다 (Wantanabe K.등, 2003).
S. kanamyceticus KCTC 9225유래와 S. hygroscopicus subsp. ascomyceticus ATCC 14891 유래 FkbG는 86%, FkbH는 83%의 상호 유사도를, FkbI는 85%, FkbJ는 77%, FkbK는 87%의 상호 유사도를 보였다. 그러나, S. sp. ATCC 55098의 FkbG는 두 개로 나누어져 있었다.
-피페콜레이트 첨가 관련 유전자, FkbP 및 FkbL
타크롤리무스, 아스코마이신, 라파마이신 및 메리다마이신(meridamycin)은 특별한 원환 아미노산인 L-피페콜레이트가 폴리케타이드에 결합하여 구성되어 있다. L-피페콜레이트는 L-라이신 유래로 L-라이신이 사이클로디아미네이션(cyclodeamination) 반응을 거쳐 생성되며 이를 담당하는 효소는 FkbL, 사이클로디아미네이즈(cyclodeaminase)로 알려져 있다. FkbL-sk는 유사체인 FkbL-asco와 89%, RapL과 76%, TubZ와 43%의 유사도를 나타낸다. L-피페콜레이트를 폴리케타이드에 결합하는 효소는 FkbP, NRPS(non ribosomal peptide synthetase)이다. FkbP-sk는 RapP와 58%, FkbP-MA5648과 95%, FkbP-Asco와 84%, MerP와 47%의 유사도를 나타낸다. FkbP는 축합 도메인, 아데닐화 도메인(adenylation domain), PCP 도메인, 그리고 다시 축합 도메인으로 구성되어 있다. 그러나 각 도메인이 어떻게 L-피페콜레이트와 폴리케타이드의 결합을 수행하는지에 대한 정확한 규명은 되어 있지 않다. FkbL에 의해 합성된 L-피페콜레이트는 아데닐화 도메인에 의해 FkbP의 PCP에 charge되고 이는 다시 FkbP의 축합 도메인에 의해 PK 구조체와 축합되어 완전한 타크롤리무스 및 그 유사구조 물질의 골격으로 최종 형성되게 할 것으로 추정된다.
-DHCHC 합성 유전자
그외 Shikimate에서 유래된 DHCHC(4,5-dihydroxylcyclohex-1-enecarboxylic acid) 혹은 이와 유사한 구조체의 합성에 관련된 유전자군은 생합성 클러스터 내에 존재하지 않았으며, 이는 아마도 크로모좀 내의 다른 위치에 존재하는 것으로 보인다. 실제 ATCC 55098의 일부 게놈 분석 결과 이들 합성에 관계할 것으로 유추할 수 있는 일부 유전자군이 발견되었다.
-프로필말로닐-CoA(ACP) 합성
타크롤리무스의 합성 중에 대체적인 합성 기작은 상기에서 기술한 바와 같이 전체 생합성 기작을 논리적으로 유추할 수 있다. 그러나, 31 위치의 곁가지 합성에 대해서는 아직 밝혀지지 않은 상태이다. 본 발명에서는 아스코마이신과 라파마이신 생합성 유전자에서는 발견되지 않으나, 타크롤리무스를 생산하는 균종 즉, S. sp. KCTC 11604BP, S. kanamyceticus KCTC 9225 와 S. sp. ATCC 55098에서 공통적으로 발견되는 4개의 유전자 tcsA,B,C,D를 확보하였다 (서열번호 3,5,7,9,56,58,60,62,64,66,95,97,99,101).
TcsA-sk(서열번호 55)는 TcsA-55098 (서열번호 94)과는 88%, TcsA-11604BP (서열번호 2)와는 79%의 유사도를 가지고 있었으며, 이들 TcsA 유사체는 AT 도메인을 가지고 있었으며, 아실기 전이효소 기능에 필요한 Gx(H)SxG의 호중 엘보(nucleophile elbow)를 구성하는 아미노산 잔기와 S. coelicolor 유래의 MAT(malonyl-CoA:ACP)와 S. hygroscopicus 유래의 RapAT2에서 촉매 작용에 관여하는 아르기닌, 히스티딘 등이 잘 보존되어 있다 (Keatinge-Clay A. T. 등, 2003).
TcsB-sk는 TcsB-55098 과 86%, TcsB-11604BP와 79%의 유사도를 나타내고 있었으며, TcsB는 폴리케타이드 합성효소에서 발견되는 KS 도메인을 함유하고 있었다. TcsB의 N 말단 쪽에 효소활성 부위가 잘 보존된 KS 도메인을 가지고 있으며, 이와 더불어 C 말단 위치에도 세 유사체 모두 잘 보존되어 있음으로 미루어 프로필말로닐 CoA(ACP) 혹은 그 유사체의 형성에 중요한 역할을 할 것으로 추정된다.
TcsC는 살리니스포라 트로피카(Salinispora tropica) CNB-476의 살리노스포라마이드(salinosporamide) A 생합성기구에 포함된 SalG (ABP73651)의 유사체이다. TcsC-11604BP, TcsC-sk, TcsC-55098은 각각 SalG 와 50%, 51%, 51%의 높은 일치도를 나타낸다. 이러한 TcsC 유사체가 아스코마이신 생합성 유전자군에서도 FkbS로 일부 존재하나 FkbS는 C 말단쪽 152개의 아미노산만 보고되어 있으며, 그 기능 또한 정확히 알려져 있지 않고 있다. 여러 마크롤라이드 생합성 유전자에서 발견되는 TcsC 유사체는 마크롤라이드의 에틸말로닐 부위와 같은 곁가지의 공급에 역할을 할 것으로 추정하고 있으나 정확한 기작은 밝혀지지 않은 상태이다. 단지 최근에 SalG가 환원 카복실레이즈(reductive carboxylase) 역할을 한다는 것이 보고된 바 있다.
TcsD는 아실-CoA 탈수소효소(ACAD)로 추정되며 TcsD-sk와 TcsD-55098과 89%, TcsD-11604BP와 87%의 유사도를 보였으며, 플레시오시스티스 파시피카(Plesiocystis pacifica) SIR-1 유래의 ACAD (NZ_ABCS01000005.1)와 49%의 낮은 유사도를 보였다. 이러한 분석으로 보아 TcsD는 일반적인 ACAD보다는 프로필말로닐 ACP(CoA)의 합성에 매우 특이적인 탈수소효소로 프로필말로닐 ACP(CoA)의 환원을 통한 알릴(프로필레닐)말로닐 ACP(CoA)의 형성에 관여할 것으로 추정된다.
start(bp) | end(bp) | Orf | predicted function | FK506 biosynthesis |
192 | 1187 | Orf(-11) | ABC transporter | not related |
1184 | 1987 | Orf(-10) | ABC transporter | |
3453 | 2758 | Orf(-9) | RNA polymerase sigma factor | |
4319 | 3600 | Orf(-8) | hypothetical protein | |
5551 | 4685 | Orf(-7) | secreted cellulose-binding protein | |
5869 | 6012 | Orf(-6) | hypothetical protein | |
6016 | 6234 | Orf(-5) | predicted flavoprotein involved in K+ transport | |
6227 | 6796 | Orf(-4) | RNA polymerase sigma factor | |
6793 | 7428 | Orf(-3) | putative oxidoreductase | |
7550 | 7735 | Orf(-2) | MscS Mechanosensitive ion channel | |
7732 | 8235 | Orf(-1) | PilT protein-like | |
8724 | 10007 | TcsA | acyl transferase domain protein | Putative tacrolimus biosythetic enzyme but not for ascomycin biosynthesis |
tcsA-AT (8733-9677), tcsA-PP (9747-9971) | ||||
10015 | 12405 | TcsB | polyketide synthase modules and related proteins | |
tcsB-KS (10060-11400), tcsB-KSb (11443-12141) | ||||
12402 | 13739 | TcsC | reductive carboxylase | |
tcsC-ER (12540-13637) | ||||
13736 | 14896 | TcsD | acyl-CoA dehydrogenase | |
tcsD-ACAD1 (13742-14068), tcsD-ACAD2 (14078-14236), tcsD-ACAD3 (14387-14872) | ||||
16063 | 14909 | Tcs1 | methionine gamma lyase | not realated |
16123 | 16590 | Tcs2 | AsnC-family transcriptional regulatory protein | |
16694 | 17923 | Tcs3 | cytochrome P450 | |
18108 | 19295 | Tcs4 | indole oxygenase | |
19308 | 20060 | Tcs5 | short-chain dehydrogenase/reductase SDR | |
fkiA-KR (19326-19871) | ||||
20232 | 20900 | FkbG | O-methyl transferase | precursor methoxymalonyl-ACP biosynthesis |
21966 | 20878 | FkbH | predicted enzyme involved in methoxymalonyl-ACP biosynthesis | |
23077 | 21977 | FkbI | acyl CoA dehydrogenase | |
24205 | 23327 | FkbK | acyl CoA dehydrogenase | |
23330 | 23070 | FkbJ | acyl carrier protein | |
25236 | 24199 | FkbL | lysine cyclodeaminase | Precursor |
36016 | 25337 | FkbC | polyketide synthase | |
M5-KS (36016-34785), M5-AT (34543-33705), M5-DH (33529-33045), M5-KR (32197-31698), M5-PP (31423-31203) | module 5 | |||
M6-KS (31141-29901), M6-AT (29662-28824), M6-DH (28645-28152), M6-ER (27391-26529), M6-KR (26503-26016), M6-PP (25783-25563) | module 6 | |||
59078 | 36138 | FkbB | FK506 polyketide synthase | |
Load-CAS (59003-57796), Load-ER (57092-56221), Load-PP (55718-55498) | loading module | |||
M1-KS (55454-54193), M1-AT (53954-53116), M1-DH (52937-52438), M1-KR (51668-51181), M1-PP (50942-50722) | module 1 | |||
M2-KS (50639-49381), M2-AT (49019-4815), M2-DH (47993-47530), M2-KR (46697-46186), M2-PP (45941-45721) | module 2 | |||
M3-KS (45662-44401), M3-AT (44165-43354), M3-DH (43202-42724) | module 3 | |||
M3-KR (41954-41440), M3-PP (41183-40963), M4-KS (40904-39643), M4-AT (39368-38512), M4-DH (38279-37795), M4-PP (36530-36310) | module 4 | |||
59326 | 60318 | FkbO | FK506 oxidase | condensation |
60315 | 64913 | FkbP | FK506 peptide synthetase | condensation & derailed |
fkbP-CD1 (60480-61376), fkbP-CAS (61932-63137), fkbP-PP (63387-63605), fkbP-CD2 (63642-64496) | ||||
64916 | 84172 | FkbA | FK506 polyketide synthase | |
M7-ESD (64916-64996), M7-KS (65009-66229), M7-AT (66473-67249), M7-DH (67403-67897), M7-ER (68693-69577), M7-KR (69605-70090), M7-PP (70364-70582) | module 7 | |||
M8-KS (70646-71905), M8-AT (72167-72964), M8-DH (73100-73501), M8-KR (74276-74761), M8-PP (75047-75265) | module 8 | |||
M9-KS (75323-76582), M9-AT (76826-77662), M9-DH (77858-78340), M9-ER (79115-79975), M9-KR (80003-80488), M9-PP (80789-81007) | module 9 | |||
M10-KS (81101-82390), M10-AT (82697-83572), M10-PP (83795-84013) | module 10 | |||
84169 | 85335 | FkbD | C9 hydroxylase | Post modification |
85332 | 86114 | FkbM | 31-O-demethyl-FK506 methyltransferase | Post modification |
88900 | 86129 | FkbN | cholesterol oxidase regulator | specific regulator |
89743 | 88955 | FkbQ | thioesterase II | editing |
fkbQ-TE (89677-89010) | ||||
89940 | 89731 | Tcs6 | Putative lipoprotein | not related |
90174 | 91598 | Tcs7 | LysR-family transcriptional regulator | not related |
92059 | 91577 | Orf(1) | conserved hypothetical protein | not related |
92031 | 93020 | Orf(2) | PE-PGRS FAMILY PROTEIN | |
93068 | 93361 | Orf(3) | melanogenic peroxidase | |
93606 | 94610 | Orf(4) | putative lipoprotein | |
95839 | 96003 | Orf(5) | No hits found | |
95621 | 94725 | Orf(6) | PE-PGRS FAMILY PROTEIN | |
96124 | 97362 | Orf(7) | Aminotransferase, class I and II |
Streptomyces sp. GT1005 | S. kanamyceticus KCTC9225 | S. sp. ATCC55098 | S. hygroscopicus subsp. ascomyceticus ATCC 14891 | S. sp. MA6548 | |||||
ORF | Length | Length | Identity/ Similarity |
Length | Identity/ Similarity |
Length | Identity/ Similarity |
Length | Identity/ Similarity |
TcsA | 427 | 426 | 79/86 | 429 | 77/85 | - | - | - | - |
TcsB | 796 | 796 | 79/84 | 796 | 77/83 | - | - | - | - |
TcsC | 445 | 445 | 90/94 | 443 | 87/94 | - | - | - | - |
TcsD | 386 | 386 | 87/92 | 386 | 86/92 | - | - | - | - |
Tcs1 | 384 | - | - | - | - | - | - | - | - |
Tcs2 | 155 | - | - | - | - | - | - | - | - |
Tcs3 | 409 | - | - | - | - | - | - | - | |
Tcs4 | 395 | - | - | - | - | - | - | - | - |
Tcs5 | 250 | - | - | - | - | - | - | - | - |
FkbG | 222 | 222 | 86/89 | 99 | 86/90 | 222 | 81/86 | - | - |
FkbH | 362 | 362 | 86/90 | 362 | 86/91 | 360 | 79/86 | - | - |
FkbI | 366 | 366 | 87/92 | 366 | 85/89 | 366 | 85/90 | - | - |
FkbJ | 86 | 86 | 85/89 | 86 | 80/88 | 86 | 73/84 | - | - |
FkbK | 292 | 283 | 88/90 | 282 | 86/89 | 282 | 83/89 | - | - |
FkbL | 345 | 345 | 89/94 | 345 | 88/92 | 345 | 86/93 | - | - |
FkbC | 3559 | 3597 | 81/86 | - | - | 3591 | 77/84 | - | - |
FkbB | 7646 | 7591 | 83/87 | - | - | 7525 | 78/84 | 7576 | 81/86 |
FkbO | 330 | 332 | 85/90 | 333 | 84/88 | 344 | 81/86 | 332 | 86/90 |
FkbP | 1532 | 1506 | 83/87 | 1592 | 77/81 | 1495 | 79/85 | 1504 | 82/87 |
FkbA | 6418 | 6408 | 84/89 | 6445 | 82/87 | 6396 | 80/86 | 6420 | 81/87 |
FkbD | 388 | 388 | 89/92 | 388 | 88/91 | 388 | 88/93 | 162 | 89/91 |
FkbM | 260 | 212 | 82/90 | 260 | 85/91 | 260 | 83/89 | - | - |
FkbN | 923 | 934 | 82/89 | 934 | 82/89 | 913 | 71/82 | - | - |
FkbQ | 262 | 255 | 84/90 | 255 | 81/89 | 247 | 83/88 | - | - |
Tcs6 | 69 | - | - | - | - | - | - | - | - |
Tcs7 | 474 | - | - | - | - | - | - | - | - |
<실시예 8> 포스미드 클론을 코스미드 클론으로 변경
접합 효율을 높이기 위해 포스미드 벡터에 탑재되어 있는 생합성 유전자를 복제수가 높은 코스미드 벡터로 이동하고자 하였다. SuperCos1 벡터(Staratagene, USA)를 제한효소 BamHI/NheI으로 절단후 T4 DNA 중합효소로 수복(Fill-in)하여 여분의 코스 부위(cos site) 1개가 제거된 SuperCos1-1을 작제 하였다. Fos1006G02를 SpeI과 XbaI으로 절단하여 약 38kb의 단편을, Fos-1004F01를 XbaI으로 절단하여 약 37 kb의 단편을, Fos-1006D05를 Spe1과 Xba1으로 절단하여 약 41 kb의 단편을 얻어 XbaI으로 절단한 SuperCos1-1 벡터에 각각 연결(ligation)하여 Cos-1006G02와 Cos-1004F01, Cos-1006D05를 작제하였다. 큰 사이즈의 삽입물(insert)로 인한 낮은 연결체(ligate)의 선별에 의한 비효율성을 해결하기 위해 람다 패키징 추출물(lambda packaging extracts)(Epicentre, Madison, WI, USA)을 이용하여 작제된 코스미드를 패키지하여 이.콜리 DH5α에 도입하는 방법을 사용하였다.
<실시예 9> 접합에 의한 방선균의 형질 전환
유전자의 발현 및 돌연변이를 위한 운반벡터의 방선균으로의 도입은 이.콜라이/스트렙토마이세스 간의 엑스콘쥬게이션(exconjugation) 방법(Kieser, T. 등, 2000)으로 수행하였다. 비 메틸화 주게(non-methylating donor)로 dam -, dcm- 인 E. coli ET12567/pUZ8002에 발현 벡터 또는 코스미드 벡터를 전기침투(electrophoration) 방법으로 도입한 다음 접합(conjugation)을 통해 이를 방선균에 도입하였다.
<실시예 10> 생합성 유전자 돌연변이체의 작제 방법
본 발명에서 사용한 돌연변이체의 작제는 Gust B. 등이(2003) 보고한 방법에 준하여 실시하였다. 돌연변이체 작제에 사용한 개시체는 표 5와 같다. 작제를 위한 돌연변이 apr-OriT 카셋은 pIJ773을 주형으로 표 5에 제시된 개시체를 사용하여 PCR로 증폭하여 약 1.4kb 단편들을 확보하였다. 확보된 단편을 Cos-1004F01, Cos-1006G02와 Cos-1006D05가 형질전환된 이.콜리 BW25113/pIJ790 균주에 도입한 균주에 전기충격법으로 도입하여 하기와 같이 돌연변이 코스미드 벡터를 만들었다.
Cos-1004F01(ΔtcsA::aac(3)IV-oriT),
Cos-1004F01(ΔtcsB::aac(3)IV-oriT),
Cos-1004F01(ΔtcsC::aac(3)IV-oriT),
Cos-1004F01(ΔtcsD::aac(3)IV-oriT),
Cos-1004F01(Δtcs1::aac(3)IV-oriT),
Cos-1004F01(Δtcs2::aac(3)IV-oriT),
Cos-1004F01(Δtcs3::aac(3)IV-oriT),
Cos-1004F01(Δtcs4::aac(3)IV-oriT),
Cos-1004F01(Δtcs5::aac(3)IV-oriT),
Cos-1006G02(ΔfkbA::aac(3)IV-oriT),
Cos-1006G02(ΔfkbD::aac(3)IV-oriT),
Cos-1006G02(ΔfkbM::aac(3)IV-oriT),
Cos-1006G02(ΔfkbN::aac(3)IV-oriT),
Cos-1006G02(ΔfkbQ::aac(3)IV-oriT),
Cos-1006G02(ΔfkbR::aac(3)IV-oriT),
Cos-1006D05(ΔtcsA-sk(::aac(3)IV-oriT),
Cos-1006D05(ΔtcsB-sk::aac(3)IV-oriT),
Cos-1006D05(ΔtcsC-sk::aac(3)IV-oriT),
Cos-1006D05(ΔtcsD-sk::aac(3)IV-oriT)를 작제하였다.
상기 작제된 돌연변이 코스미드를 각각 E. coli ET12567/pUZ8002로 옮긴 후 실시예 9의 엑스콘쥬게이션을 통해 스트렙토마이세스속 KCTC 11604BP와 스트렙토마이세스 카나마이세티쿠스 KCTC 9225로 형질전환하였으며, 이를 통해 아래와 같이 각 유전자의 돌연변이체를 확보할 수 있었다.
S. sp. KCTC 11604BP(ΔtcsA), S. sp. KCTC 11604BP(ΔtcsB), S. sp. KCTC 11604BP(ΔtcsC),S. sp. KCTC 11604BP(ΔtcsD), S. sp. KCTC 11604BP(Δtcs1), S. sp. KCTC 11604BP(Δtcs2), S. sp. KCTC 11604BP(Δtcs3), S. sp. KCTC 11604BP(Δtcs4),S. sp. KCTC 11604BP(Δtcs5), S. sp. KCTC 11604BP(Δtcs7), S. sp. KCTC 11604BP(ΔfkbA), S. sp. KCTC 11604BP(ΔfkbD), S. sp. KCTC 11604BP(ΔfkbM), S. sp. KCTC 11604BP(ΔfkbN), S. sp. KCTC 11604BP(ΔfkbQ), S. sp. KCTC 11604BP(ΔfkbR), S. kanamyceticus KCTC 9225(ΔtcsA), S. kanamyceticus KCTC 9225(ΔtcsB), S. kanamyceticus KCTC 9225(ΔtcsC), S. kanamyceticus KCTC 9225(ΔtcsD)
돌연변이체는 서던 블랏 및 PCR로 이중 교차 돌연변이체(double cross over mutants)임을 확인하였다.
Strain | Target gene | Primer | Sequences (3'→5') |
S. sp. GT1005 |
tcsA | tcsA_F_del | gaccggcccgggccatcccgacgaaaggacgatgacatgattccggggatccgtcgacc |
tcsA_R_del | ccctccccgtccggagcacgggagatcacgaccggatcatgtaggctggagctgcttc | ||
tcsB | tcsB_F_del | gcaccggttccgtttccgggcggcggtgatccggtcgtgattccggggatccgtcgacc | |
tcsB_R_del | cgtcggcgggggagagggtgatcaccgggcccggttcgctgtaggctggagctgcttc | ||
tcsC | tcsC_F_del | gccatcgccgcctgcgaggtcccggccggctaccgggccattccggggatccgtcgacc | |
tcsC_R_del | ggggtcgcgcactcccatgccggggcggtcggcgaggcatgtaggctggagctgcttc | ||
tcsD | tcsD_F_del | cgacagcatcaacctgttccggaaggggcagccccggtgattccggggatccgtcgacc | |
tcsD_R_del | acccaggccctgacgcgggactgaccagaacatgccctatgtaggctggagctgcttc | ||
fkbA | fkbA_F_del | cgtacccgtcaccggccccgtgggaagcgagtagccgtgattccggggatccgtcgacc | |
fkbA_R_del | gtccggcgggcgtcgtctcgtcgggtgtgtcggtgctcatgtaggctggagctgcttc | ||
fkbD | fkbD_F_del | acgacgcccgccggacgctgcccgttcgcgatccaggacattccggggatccgtcgacc | |
fkbD_R_del | ggcgaggcggacgtccgggaagcgttcgaacaaccgcagtgtaggctggagctgcttc | ||
fkbM | fkbM_F_del | cagcccggccgaactgcggatcacctggggtacggcgtgattccggggatccgtcgacc | |
fkbM_R_del | ccggggcgaccggtgcgggtagccgcccccggcggctcatgtaggctggagctgcttc | ||
fkbN | fkbN_F_del | gaacggcgcagaacccatggagacgacggccgcgaggtgattccggggatccgtcgacc | |
fkbN_R_del | cgcacggcggccggccggctgagccgccgggggcggctatgtaggctggagctgcttc | ||
fkbQ | fkbQ_F_del | gcacggcgtccccacggtgcccggggcccggaccggatgattccggggatccgtcgacc | |
fkbQ_R_del | atgggttctgcgccgttcatctactggtaaatgcagctatgtaggctggagctgcttc | ||
tcs7 | tcs7_F_del | tgacggcacttgagccgtccggtgatggaattctgaatgattccggggatccgtcgacc | |
tcs7_R_del | tatcgcctatgcgctcagcgagggagcgggggattctcatgtaggctggagctgcttc | ||
tcs5 | tcs5_F_del | tgaggggggccgacgatgacgacggcaggcctccgggtgattccggggatccgtcgacc | |
tcs5_R_del | gggggcggcatcgcgatcgcagggcgcggggccgcgtcatgtaggctggagctgcttc | ||
tcs4 | tcs4_F_del | gtaccggggcggcacgacgaaagggcagggacgactgtgattccggggatccgtcgacc | |
tcs4_R_del | cacccggaggcctgccgtcgtcatcgtcggcccccctcatgtaggctggagctgcttc | ||
tcs3 | tcs3_F_del | gtcgttccatccaccctctgtctccaaggagacctcgtgattccggggatccgtcgacc | |
tcs3_R_del | ctgttgagagcggacatccctgccgtcggccgggggctatgtaggctggagctgcttc | ||
tcs2 | tcs2_F_del | aggatcagtgactgaatctcgcactacattcggtccatgattccggggatccgtcgacc | |
tcs2_R_del | ccgcccgacctgccgacgaatcrccgattcagatcactatgtaggctggagctgcttc | ||
tcs1 | tcs1_F_del | agtcactgatcctgacgctttgcgaagactgtcgtcatgattccggggatccgtcgacc | |
tcs1_R_del | gtccccaccgcgaaacgtacctagggcatgttctggtcatgtaggctggagctgcttc | ||
S. kanamyceticus KCTC9225 |
tcsA | tcsA_sk_R_del | caactcgagccggtgcagcctctgttgttctcgcctgacattccggggatccgtcgacc |
tcsA_sk_F_del | cgtggcatacgttcccgcggtggcgtcgtggaccctgtctgtaggctggagctgcttc | ||
tcsB | tcsB_sk_R-del | cgcgcctacgtacgcacctcgggcttcctgcacgacttcattccggggatccgtcgacc | |
tcsB_sk_F_del | ggcgagcgggttcaggccgtgggcgcgggcgaccgagtctgtaggctggagctgcttc | ||
tcsC | tcsC_sk_R_del | gtcgtcctcgcggcggaccagcaggctctcgcgggaacgattccggggatccgtcgacc | |
tcsC_sk_F_del | ggcgtgggtggcgtcgccgacggcgtcgaggggataggctgtaggctggagctgcttc | ||
tcsD | tcsD_sk_R_del | ctggcgttgtacgagcggttcgcggagacgggcctgatgattccggggatccgtcgacc | |
tcsD_sk_F_del | cgaggcgtgccggacgtcccgcagcagcttgccgatcggtgtaggctggagctgcttc |
strains | Function | Bioassay | Metabolites | ||
FK506 | FK520 | Others | |||
Wild type | +++ | +++ | + | + | |
ΔtcsA | allyl malonyl ACP biosynthesis | + | - | + | + |
ΔtcsB | allyl malonyl ACP biosynthesis | + | - | + | + |
ΔtcsC | allyl malonyl ACP biosynthesis | + | - | + | + |
ΔtcsD | allyl malonyl ACP biosynthesis | + | - | + | dihydro FK506 |
Δtcs1 | Methionine gamma lyase | +++ | +++ | + | + |
Δtcs2 | AsnC-family transcriptional regulatory protein | +++ | +++ | + | + |
Δtcs3 | Cytochrome P450 | +++ | +++ | + | + |
Δtcs4 | Indole oxygenase | +++ | +++ | + | + |
Δtcs5 | Short-chain dehydrogenase | +++ | +++ | + | + |
ΔfkbA | FK506 polyketide synthase | - | - | - | - |
ΔfkbD | P450 9-deoxo-FK506 hydroxylase | +++ | - | - | +++ |
ΔfkbM | 31-O-demethyl-FK506 methyltransferase | +++ | - | - | +++ |
ΔfkbN | transcriptional regulator | - | - | - | - |
ΔfkbQ | type Ⅱ thioesterase | +++ | +++ | + | + |
Δtcs7 | Lys R-family transcriptional regulator | +++ | +++ | + | + |
<실시예 11> 삼원환 화합물 생합성 유전자 영역 결정
확보한 유전자가 타크롤리무스 생합성과 아스코마이신 등의 삼원환 화합물 생합성에 관여하는 생합성 유전자임을 증명하기 위해 FkbA 결손 돌연변이체를 제작하여 분석하였다. FkbA는 타크롤리무스 폴리케타이드 합성효소이며 4개의 모듈을 포함하고 있고, 폴리케타이드 골격의 생합성에 핵심적인 효소이다. 실시예 10에서 작제한 fkbA 결손 변이체, 스트렙토마이세스속 KCTC 11604BP(ΔfkbA)의 배양체에는 어떠한 항진균 활성도 나타내지 않았다. 또한 타크롤리무스 및 아스코마이신, DH-타크롤리무스, FK525 등 어떠한 타크롤리무스 유사체도 실시예 2의 HPLC와 LC-MS로 확인할 수 없었다(도 4). 이는 본 발명에서 확보한 유전자 군이 타크롤리무스와 아스코마이신을 포함하는 그 유사체의 생합성 기구 형성에 필수적임을 증명하는 것이다. 이러한 사실로부터 기존의 아스코마이신과 타크롤리무스 생합성 기구가 서로 상이할 것으로 예측한 것과는 달리 타크롤리무스와 아스코마이신 합성이 동일한 기반에서 이루어짐을 확인할 수 있었다. 즉, 본 발명에서 확보한 유전자는 타크롤리무스는 물론 아스코마이신과 그 구조 유사체의 합성 및 변형에 이용될 수 있음을 의미한다.
또한, 실시예 10에서 작제한 조절인자 fkbN 돌연변이체인 스트렙토마이세스속 KCTC 11604BP(ΔfkbN)도 스트렙토마이세스속 KCTC 11604BP(ΔfkbA)와 동일하게 항진균 활성이 소실되었으며, 실시예 2의 HPLC분석으로 어떠한 타크롤리무스 유도체의 생성도 확인할 수 없었다. 즉 FkbN이 타크롤리무스 생합성 유전자의 매우 특이적인 양성 조절인자임을 확인하였다.
이렇게 확인된 타크롤리무스 생합성 유전자군에서 타크롤리무스 생합성에 직접적으로 관여하는 유전자를 확인하고자 하였다. 아스코마이신 생합성 유전자 로 알려진 fkbG와 fkbN를 벗어나는 유전자 영역이 타크롤리무스 생합성에 필요한지를 검증하였다. fkbG를 벗어나 존재하는 tcsA,B,C,D,1,2,3,4,5와 fkbN을 벗어난 fkbQ,7의 변이체를 실시예 10과 같이 작제하여 그 대사물질을 분석하였다. 그 결과, tcsA,B,C,D 돌연변이체인 S. sp. KCTC 11604BP(ΔtcsA), S. sp. KCTC 11604BP(ΔtcsB), S. sp. KCTC 11604BP(ΔtcsC), S. sp. KCTC 11604BP(ΔtcsD)의 경우 타크롤리무스 생산이 HPLC로 검출되지 않았다(도 4). 그러나, fkbQ 및 Tcs1,2,3,4,5,7 돌연변이체는 여전히 타크롤리무스 및 아스코마이신을 생산하였다(도 4). 이로 미루어 필수적인 타크롤리무스 생합성 유전자는 tcsA,B,C,D를 포함하여 fkbG에서 FkbN까지로 추정할 수 있었다. 또한 이들 유전자는 타크롤리무스 생합성 유전자군에서 모두 공통적으로 확인되는 유전자들이다(도 2).
<실시예 12>
tcsA,B,C,D
돌연변이체의 LC-MS/MS 분석 및 타크롤리무스 생합성
실시예 10에서 작제하고 실시예 11에서 분석한 것과 같이 tcsA,B,C,D 돌연변이체는 타크롤리무스 생산을 HPLC로 확인할 수는 없었다. 또한 실시예 10에서 작제한 S. kanamyceticus KCTC 9225(ΔtcsA), S. kanamyceticus KCTC 9225(ΔtcsB), S. kanamyceticus KCTC 9225(ΔtcsC), S. kanamyceticus KCTC 9225(ΔtcsD) 또한 타크롤리무스 생산을 HPLC로 검출할 수 없었다. 그러나 이들 균주들은 야생형인 S. sp. KCTC 11604BP보다는 낮지만 여전히 높은 항진균 활성이 확인되었다. 이로 미루어 항진균 활성을 가진 타크롤리무스나 아스코마이신 또는 그 유사체가 일부 생산될 수 있음이 추정되었다. 유도체의 존재를 확인하기 위해 S. sp KCTC 11604BP 균주와 그 돌연변이주들 배양체를 이용하여 LC-MS/MS로 대사체를 좀더 면밀하게 분석하였다. LC-MS/MS 결과 각 돌연변이체에서 확인된 물질은 표 7 및 도 5와 같다. 흥미롭게도 S. sp. KCTC 11604BP(ΔtcsA), S. sp. KCTC 11604BP(ΔtcsB), S. sp. KCTC 11604BP(ΔtcsC)의 경우 아스코마이신(타크롤리무스의 에틸 폼) 및 FK523(타크롤리무스의 메틸 폼)가 여전히 생산되고 있음을 확인할 수 있었으며, S. sp. KCTC 11604BP(ΔtcsD)에서는 37, 38-다이하이드로폼의 타크롤리무스 유도체가 생산되고 있음을 확인할 수 있었다. 이러한 결과로 보아 tcsA, B, C, D는 타크롤리무스 21번 위치의 곁사슬 형성에 매우 중요한 역할을 하는 유전자임을 확인할 수 있었다. S. sp. KCTC 11604BP(ΔtcsB), S. sp. KCTC 11604BP(ΔtcsC)에서는 매우 적은 양의 타크롤리무스가 생산되는 것으로 보아 케토합성효소(Ketosynthase)와 환원카복실레이즈(reductive carboxylase)를 일부 대체하는 유사체가 존재하여 일부 미약하게 기능하거나, 복합배지를 사용하는 발효조건에 의한 알릴 (프로필레닐) 말로닐산 혹은 그 유사체(예, 4-페테노익산, 발레릭산 또는 프로필 말로닐산)가 직접 TcsA-ACP에 도입(charging)되어 극미량 생성된 것으로 추정된다. 그러나, S. sp. KCTC 11604BP(ΔtcsA)에서는 타크롤리무스가 전혀 검출되지 않았으며, 이는 알릴-말로닐 부분을 주요 PKS (모듈 4의 ACP 혹은 AT)로 전달하는 데에 TcsA의 AT 및 ACP 도메인이 절대적인 역할을 하기 때문일 것이다. 또한 S. sp. KCTC 11604BP(ΔtcsD)는 모든 화합물의 21위치의 곁사슬이 포화 형태(saturated form)로만 발견되었다. 이는 아실-CoA 탈수소효소(ACAD)로의 역할의 소실로 인한 것으로 추정할 수 있다. 상기의 결과로부터 추론할 때, TcsA,B,C,D는 타크롤리무스 곁사슬(side chain) 형성에 도 6과 같이 추정되는 메카니즘으로 타크롤리무스 및 그 유도체의 합성에 중요한 역할을 할 것이다.
상기 TcsA,B,C,D와 그들의 유전자 돌연변이체의 활용 또는 유전자의 개별 또는 집단 도입을 통한 단백질 발현 등의 활용은 신규 물질 생산, 타크롤리무스 및 그 유연물질, 또는 신규로 생산될 수 있는 타크롤리무스 유연물질의 생산 증대 또는 아스코마이신과 같은 타크롤리무스의 중요한 불순물의 제거를 도모하는데 매우 유용할 것으로 추정된다.
Strains | LC/MS 결과 |
WT(GT1005) | 9-deoxo-31-O-demethyl-ascomycin: Mr 763.4870 (m/z 786.4[M+Na]+) 9-deoxo-31-O-demethyl-tacrolimus Mr 775.4870 (m/z 798.4[M+Na]+) 9-hydroxy-tacrolimus: Mr 805.4976 (m/z 828.49[M+Na]+) 9-deoxo-31-O-demethyl-dihydro-tacrolimus: Mr 777.5027 (m/z 800.5[M+Na]+) Prolinyl-tacrolimus (FK525): Mr 789.4663 (m/z 812.46[M+Na]+) ascomycin (FK520): Mr 791.4819 (m/z 814.48[M+Na]+) tacrolimus (FK506): Mr 803.48198 (m/z 826.48[M+Na]+) Decarbonyl-tacrolimus(9-deoxo-FK506): Mr 789.5027 (m/z 812.5[M+Na]+) dihydro-tacrolimus: Mr 805.49763 (m/z 828.48[M+Na]+) |
ΔtcsA
(acyltransferase) |
L-687819: Mr 763.45068(m/z 786.4301[M+Na]+) (L-683795) FK523: Mr 777.4663(m/z 800.4587[M+Na]+) ascomycinFK520: Mr 791.48198(m/z 814.46[M+Na]+) |
ΔtcsB (ketosynthase) |
L-687819: Mr 763.45068(m/z 786.4301[M+Na]+) FK523: Mr 777.4663(m/z 800.4502[M+Na]+) ascomycin (FK520): Mr 791.48198(m/z 814.4682[M+Na]+) FK506: Mr 803.48198(m/z 826.4683[M+Na]+)(highly decreased) |
ΔtcsC (crotonyl CoA reductase -reductive carboxylase) |
L-687819: Mr 763.45068 (m/z 786.4301[M+Na]+) FK523: Mr 777.4663 (m/z 800.4502[M+Na]+) ascomycin (FK520): Mr 791.48198 (m/z 814.4682[M+Na]+) tacrolimus (FK506): Mr 803.48198 (m/z 826.4683[M+Na]+(highly decreased) |
ΔtcsD
(acyl-CoA dehydrogenase) |
31-O-demethyl-ascomycin: Mr 777.4663 (m/z 800.4655[M+Na]+) 31-O-demethyl-DH-tacrolimus: Mr 791.48198 (m/z 814.4718[M+Na]+) 9-deoxo-31-O-demethyl-DH-tacrolimus: Mr 777.50271 (m/z 800.4936[M+Na]+) ascomycin (FK520): Mr 791.48198 (m/z 814.46[M+Na]+) 9-deoxo-ascomycin: Mr 777.50271 (m/z 800.4928[M+Na]+) Prolinyl-dihydro-tacrolimus: Mr 791.48198 (m/z 814.48[M+Na]+) dihydro-tacrolimus: Mr 805.49763 (m/z 828.479[M+Na]+) 9-deoxo-dihydro-tacrolimus: Mr 791.51836 (m/z 814.5[M+Na]+) |
<실시예 13> 디옥소- 및 디메틸레이티드형 타크롤리무스 유도체 고생산
실시예 10에서 작제된 돌연변이체들 즉, S. sp. KCTC 11604BP(ΔfkbD), S. sp. KCTC 11604BP(ΔfkbM)의 타크롤리무스 및 그 유사체의 생산을 확인하였다. 이 두 변이체는 타크롤리무스 생산 능력은 소실되었다. 그러나, S. sp. KCTC 11604BP(ΔfkbD)는 타크롤리무스의 디옥소(deoxo) 유도체인 9-디옥소-31-O-데스메틸-타크롤리무스를 포함하여 9-디옥소-31-O-데스메틸-아스코마이신, 9-디옥소-31-O-데스메틸-36,37-다이하이드로-타크롤리무스를 생산함을 확인하였다. 또한 S. sp. KCTC 11604BP(ΔfkbM)는 데스메틸 폼인 31-O-데스메틸-타크롤리무스, 31-O-데스메틸-아스코마이신, 31-O-데스메틸-36,37-다이하이드로-타크롤리무스를 생산함을 확인하였다. 특히 상기 물질은 fkbD와 fkbM 돌연변이체에서 야생주인 S. sp. KCTC 11604BP에서보다 매우 높은 생산이 가능함을 확인하였다. 특히, 9-디옥소-31-O-데스메틸-타크롤리무스와 31-O-데스메틸-타크롤리무스는 S. sp. KCTC 11604BP(ΔfkbD)와 S. sp. KCTC 11604BP(ΔfkbM)에서 각각 야생형 균주에서 생산되는 타크롤리무스 생산량에 비견될 수 있는 80~150㎎/ℓ로 고생산이 가능하였다.
도 1은 삼원환 화합물의 구조(화학식)이다.
도 2는 타크롤리무스 생합성 유전자군을 나타낸다. 각각 (A), 스트렙토마이세스속(Streptomyces sp.) KCTC 11604BP ; (B), 스트렙토마이세스 카나마이세티쿠스(Streptomyces kanamyceticus) KCTC 9225; (C), 스트렙토마이세스속(Streptomyces sp.) ATCC 55098 균주로부터 확보하였다.
도 3은 생합성 유전자군의 모듈(Modules)과 도메인 구성 및 추정 생합성 과정을 나타낸다. 위쪽 도메인 구성은 스트렙토마이세스속(Streptomyces sp.) KCTC 11604BP, 아래쪽은 스트렙토마이세스 카나마이세티쿠스(Streptomyces kanamyceticus) KCTC 9225 유래의 것이다.
도 4는 생합성 유전자 돌연변이체의 HPLC 분석 결과이다.
(a),(f), S. sp. KCTC 11604BP; (b), S. sp. KCTC 11604BP(ΔfkbA) d; (c), S. sp. KCTC 11604BP(ΔfkbN); (d), S. sp. KCTC 11604BP(Δtcs1); (e), S. sp. KCTC 11604BP(ΔfkbQ); (g), S. sp. KCTC 11604BP(ΔtcsA); (h), S. sp. KCTC 11604BP(ΔtcsB); (i), S. sp. KCTC 11604BP(ΔtcsC); (j), S. sp. KCTC 11604BP(ΔtcsD)
화합물 1, 타크롤리무스; 화합물 2, 아스코마이신; 화합물 3, 36,37-다이하이드로-타크롤리무스
(a)-(e), HP-20 레진의 첨가 없이 발효 배양하여 분석하였다.
(f)-(j), 5% HP-20 레진을 첨가하여 발효 배양하여 분석하였다.
도 5는 방선균 배양액의 총이온 질량스펙트럼 분석 결과이다.
(A), S. sp. KCTC 11604BP; (B), S. sp. KCTC 11604BP(ΔtcsA); (C), S. sp. KCTC 11604BP(ΔtcsB); (D), S. sp. KCTC 11604BP(ΔtcsC); (E), S. sp. KCTC 11604BP(ΔtcsD)
도 6은 타크롤리무스 C-21 측쇄의 합성과정 추정도이다.
약어: KS, 케토합성효소(ketosynthase); AT, 아실기 전이효소(acyltransferase); ACP, 아실기 운반 단백질(acyl carrier protein); aDH, 아실-ACP(CoA) 탈수소효소{acyl-ACP(CoA) dehydrogenase}; R/C, 환원효소/카복실라제(reductase/carboxylase)
도 7은 FkbD, FkbM 돌연변이체 배양액의 HPLC 분석 결과이다.
(a), S. sp. KCTC 11604BP, (b), S. sp. KCTC 11604BP(ΔfkbD); (c), S. sp. KCTC 11604BP(ΔfkbM)
피크: 1, 타크롤리무스; 2, 아스코마이신; 3,9-디옥시-31-디메틸-타크롤리무스; 4,9-디옥소-31-디메틸-아스코마이신; 5,9-디옥소-31-디메틸-36,37,-다이하이드로타크롤리무스; 6,31-디메틸-타크롤리무스; 7,31-디메틸아스코마이신; 8,31-디메틸-36,37-다이하이드로타크롤리무스.
배양은 레진 첨가 없이 진행하였으며, Sep-Pack(C18)으로 간단히 정제후 분석하였다.
SEQUENCE LISTING
<110> GENOTECH CO., LTD.
<120> GENES AND PROTEINS FOR BIOSYNTHESIS OF TRICYCLOCOMPOUNDS
<130> GENOTECH-0912-Ta
<160> 169
<170> PatentIn version 3.3
<210> 1
<211> 97725
<212> DNA
<213> streptomyces sp. GT1005
<400> 1
gagtcgacgg ggatcacgga gttcccccag tggccggccg ccagaacaag cgctccctgg 60
ctgctttccg attcgatcta cctcgggccc agcaacgatc tggcagtggc ggagatcgca 120
aagatgctgc acccgaccgg ctcctgaccc ggccgggccg gcgcaagcag ccgaactccg 180
tcctcgtctt ggtggggctg ctggccgtgc tcctggtggc catggtcctg gcgatcagca 240
tcggagccgt gaccgtgccg gtgggtgagg tgtggcggat catctggcac cgcatcaccg 300
gcagcggaac ggtcaccgac cccgccatgg accagatcgt ctggaacttc cgcaccccgc 360
gcgtcgtcct cgcggcgctg gtcggcgcgg ggctcgcgat cgccggtgtg gtcctgcagg 420
ccgtcgtcgc caacccgctc gccgacccgt acgtcctggg cgtctcgtcc ggtgcgtcac 480
tcggcgccgt gctcgtcatc accctcacca gcggtgcgct cggcggcctg ggagtgtcgt 540
cggcggcctt cgtcggcgcc gcgctggcgg ccgcgctggt cttcttcctc ggccagaaac 600
aagggcgtct cgcaccgacc cgcctggtcc tgtccggtgt ggccgtgggc tatctgttcc 660
tggccgccac cagctatctg cagctccagg ccactccgac cgaactgcgc acggtcatgt 720
tctggatgct gggcagcgtc gccggcgcac agtgggggca gctccccctc gtcaccaccg 780
tcgtcatcgc caccaccgtg gtcctggccc tcttcggccg ccggctcaac gccctcctcg 840
tcggcgacga atccgccacc gccctcgggg tcgacgtaca ccggctgcgc gccgtgctgc 900
tggcgctgtc ctccctggtg accgggacgg tcatcgccgt cgccggggga atcggcttcg 960
tcggcctgat gatcccccat ctggtgcgcc tcacgaccgg cgccgaccac cgcaggctgc 1020
tcccccaggc tgccctggtc ggcgccatct acctggtcgt cgtcgacctg ctcgcccgca 1080
ccgtccaccg ccccaacgaa ctgccgctcg gtatcctcac cgccctgttc ggggccccct 1140
tcttcctgtg gctgctgcgc cgcaacaaga gcctggacac cgcatgaagc tgaccgtcga 1200
agagatccac gtcgaactcg gccggaagcc gatcctccac gatgtgaacc tggaggccgg 1260
gccgggcgat atcgtcggcc tcatcggccc caacggcagc ggcaaatcga cgctgctgcg 1320
gacggtctac cgttcgctgc gcccccaccg cggtgtggtg cgtgtggacg gggacgacgt 1380
ctgggggctg agcgcgcgca atgccgcccg ccgtaccgcc gccgtcctcc aggacgccgg 1440
gagcaatccg tccggcctct gcgtcacgga ggtggtggcc ctcggccgga ccccgcacca 1500
cgggctcgtc ggccgtgaca gcgccgagga ccacgaggcc gtggaccagg ccctcgacct 1560
gtgcgggatc cagcacatgg ccggacgcga cgtcacctcc ctgtccggag gcgagcgcca 1620
gcgggtgctg ctggcgcgcg ccttggccca gcggccccgg ctcctcgttc tcgacgagct 1680
caccaaccat ctggacgtcc gcgcccgctt cgaactcctg gacctcatcc gggcgaccgg 1740
catcacgacc ctcgccgtcc tccacgacct cgacctggcg gcccggctct gcgaccacct 1800
ggtggcgctc cactcgggcc gggtggtggc cgcgggcccg gtcctggagg tgctgacgcc 1860
cggtctgctg cgcgaggtgt tcggcgtggc gggcactgcc gaccgtcacg ccgacggcat 1920
cgtacgcatc acctatgcgg cgcagcccct ggccctggag cggctgtcgg aggccggggt 1980
cggctgacgg gacggtcgta ctgcgtcccc cggcggacct cggccgatgc ctccgcgctg 2040
tcgaggcgtt ccaccaggtg gaaggccatg tcgatgccag cggagacacc cgcgctggtg 2100
acgatggtgc cgtcgtcgac ataccgttcg gcggcgcgga cgtcgatcgt gccgtccagg 2160
gccgccagtc tttcggtgaa gtcgcggtgc gtggtcgcgg gccggtcccg gagcagtccg 2220
gcggccgcca gtacgagtga accggtgcac acgctcgcca gcagcacctc gcgacggtgc 2280
agctccctga gccactccag atgcgcgccg tcgtccttga gcgcgcgcgt gccgtcaccg 2340
cccgggtgga tcagcacgtc gagtgcggga gcgtcggcag ggctgtggtc cacgcccagg 2400
cgcagcccct tggcgcagcg cacccatccc tcctcccggg cgaccgtgac caggcggacg 2460
ggtgccgtgg cgacgtgggc ggcccagaag ccgaggactt cccaggggcc gacgacatcg 2520
agttcctcgg cgccctcgaa cacgaaaacg cctacggtca gcgcggactc cagatccggt 2580
gagctcacta acgccccctg catgtcgatg agttgaggca tcaccctgac acgggagccg 2640
gtggctgtcc cgggagcgcc aaccgaagaa cccgaaggaa tgaaattgcg taccgcggcg 2700
ccgccgtccg gtcgaggtcc ggtgcgcgcc ccacgggcca cgcaccggac ctcgccgtca 2760
tgcagccgcg ccggccagga cggataccgc cgtatgggac ggtgggacgg ccggaatcag 2820
gtcgtcgccg tccgtgcggg gctgttccgg ctcggcgagc aggaccagca gcatcgagcg 2880
ggcgcgggcc acccgcgaac ggatggtccc gaccgggcag tcggtgacat cggcggcctc 2940
cgcgtacgac aggcccagca gctgcgtgag gatgaacgcc tcgcggcgtt cgtccggcag 3000
cgctgccagc aggtcgagga gtgcgatgcc ctcctcgaag cccggcacgc cgaccggctg 3060
ggtctgttcg gcggcccgcc gccagtcctg gcgatcggcc agccgggggc gcgcggcggc 3120
ccgccggaag tcgtcgatca cggcccggcg tgcgatcgac agcagccagg cgcgggccga 3180
ggagcggccc tcgaaccggt gcaggctgcc cagggcacgt atgaacgtct cctgggtcag 3240
atcgtccgcc gactgcgggt cggcgctcag ataggcgaca tagcgcagta cgtcgtagtg 3300
cagagcgcgg atgaaccgtt cgacggcgtc cggatcgccg ccccgggcgg ccagcgccca 3360
gccggtgatc agctgatcgg cctcctcggt cctgtcgtgc ttcttacgtc tgttgcgggg 3420
cccgcgtaat gcgggcaggg caggagcaag cacctggtgt ccttcgcgaa tcgcacaggg 3480
aacggcggca cacggacctg ccggttccgg ctgtaggggg acggcggccg tgcgcgggca 3540
cgaccgtgaa ccggagcggg gcgccgaaga cgcccgaagc cccgggaaga cctgctgttc 3600
tagatgacag cggtcctcaa gggcggtccc ctgctggtga tcgcatggac gagatgcagg 3660
tggtacggcg cccagcgcga gcggttccgc cgcaccagac ggcgcgggcg gcgcggcagc 3720
gcgggcaggg tgagcgccgg ccgcaacggc gcggccagcc atccggcgac ggcgcgcacc 3780
aggcggtagg cgacacgttc gccgtaggcc agccacaggc cgcacagcac tgcggccacg 3840
aggtgggctc cggacatgcc gagcgacggc atgctgctca ccagccagtg ccccaggtcg 3900
gagccggtgt ccgggcttgc gtgggccgag tggcccatgc ccatgggcat cttcatgagc 3960
agggagtgcg catggctgcc gcccgtttcg gcggcgcccg cgccgtgtcc cgcggagccg 4020
gccggggtgc ctcccggggc ggggggcgcc gctgccgcct gtgcgagtga gaatccccag 4080
tggagcatct tctgggcgcc gacgacgagc gtcacgatca gcgccgtacc gcgttcccgg 4140
ccggccagca cccagccgac gccgcccgtt gccacacctc cggccacgag tgcccaccag 4200
ggcacggcgc agcaggacat caaggtgtgc ccgatggcag cgagcagcac gcacacggcc 4260
gcgaacaacg cggcccgtac cgtgcgcaca taccaaccgg catccatgac tggcttcatc 4320
cttgcacccg aattgcggtc gttatggatc aagtatccaa agtcacgggg tgccccactc 4380
aaggggaccg gtgtgattca ggacgtgatc tgccggggaa ccgatcaccc cgtcgagccg 4440
actccataga gggcagtctg cctgtggacg tccggatgcg ggagggtgcc tccgtccggg 4500
tcggatgcgg cggtgaagtg gtggggtgct tccggggtgc gccggaaacg gcttcggcgc 4560
ggggctttcg ccccgcgccg aaactcgtca ttgttcagtt gtgctgctgc gttccgcgcg 4620
ctcccggacg accggtgggt tcggcccggt cagagccttc cgcgagtgcg ctgcgggagc 4680
cgtctcagtt ggtcctgcgg cggctgcggt tgagcagcag ggcgcccacg gcgaacaccg 4740
cggcacctcc cgcccaggtc acggcaccga cgggcgagga gcccgcgggc tgcgattcgg 4800
cggaggccag cgcgggggcc tgctcgtccc cgccgtgacc cgagtggctc acggtcgaga 4860
gggacgcgcc cgcgtcgatc ttcgcctggg tcggcgcctt ggccgtggcg gccgaagagc 4920
cgaagacgac gtccgagcag ccgtagaacg cctcggggct gtcgtggcgc tgccagacct 4980
tgtagacgat gtggcggccc gtgcgggcgg gcaggttgcc ggtgaagcgg tagtagccgt 5040
tgtcgctgac gcgcggcgtg gcgtgggtgc cgaccggggt cgggtccagg tccgaccact 5100
tgaggggctt cgtggggtcg aagcccggct tggtgatgta catcgtcatc gtgcccaggt 5160
gggccgcggt gatccgcacg ttgaagttgt acgaaccggc ggccacgttc gtggcgggcc 5220
agtcggcgcg ggcccagtcc agggcgcggt acttcacgcg gttggcggag cagagctttc 5280
cgtcggggat gagctccttg tgcttgccgt tcgcgttggc gatgttcacc tcgttccagt 5340
cgtacagcgg ctgggtgccc gagtccgcga caaggtcctt acagacctgg gacttgggcg 5400
tctccgggcc ttcggcgaag caggcactca ccctgctgac cggaccgaag acggaaccgt 5460
gggcgctcgc gggggtcggc gccagggaga cgaaggtcgc ggcggaagcg accacggagg 5520
ccgcggcaat gcggcgtcgt gcggaagaca tagtggctca ctctcgtacg tgtagggccg 5580
tcgggagtaa cggggtaaca ccggcccgac cgtggggggt tggagcggtg gtctgaacca 5640
gaggatcgca ttggtacaca ccaatcacaa gagggtgcgc ccgatgtacc ccggaatggc 5700
agcctttccg gtgggtgtac ggggcggcct cggagccgta ccgcagactt ccgtaccgcc 5760
tccgtccttc ggagatcctc ttcggtccgg taccgcggac gcctgtcctc cgcgccctgc 5820
ggaccgcggc ggcccgggcc gatatcgccc gcgtgatgac gacgacccgt gcaccgtgcc 5880
gccgccggca acggcggcgg ccggatgcgc cggttcgccg atgtcacact ttcgggcagc 5940
acctgcactc aacggatgag gggcctcgac agggtgtccc cgagggcgaa ccgcgtatcg 6000
gaacaggggt agcggatgct ggaagtcttt gccggattga gcggtgtcgt cgtactgctg 6060
ggaacacgtc tggcgtatca gtggatccgg ggtcggacgg aggtcgagct ggcccgggtg 6120
gcccgggaga ccgcggccgg tctgccgccg ggcagtgtgc tcaccgatcg gcgcccgggc 6180
agcgagctac gggtgcagat cgggcccgga ttccgggggc agtcgcatgg ctgaggcccc 6240
gggccacccc gccgtcccgg tggcgcagcc gttacgcccg cccgacccgg acacacggcc 6300
gggcgccgag ttcgcccgct actacgaaca gcagatgccc cggctgctca ttcatctggt 6360
ccgccggggg gcgagctggc acgaggccgg ggaagccgcc caggccgcct tcaccgaggc 6420
gttcacccag tgggatcgca tcgcacaccc cgccggctgg ctgcggctgg tcgcctaccg 6480
cctctatctg cgccgccccg cacgccggga ggagcccacc gaccagctgc ccgacgggcc 6540
cggaggcagc tgtccgctgc acaaggtgga actgaaggag tccgagcagt gggtcctgtc 6600
cgctctgtcg gccctgccgt cgcagcagag cgcggtcatg gcctggcacc tcgacggctt 6660
cgccacccgg gagatcgcgg aggccctcgg gaccaccccg gcagcggtac ggcagaacct 6720
cgccagggcc cgcgcccggc tcaagacgat cctgctcgca cccaccgacc ggacaggaga 6780
cggaggccgg gaatgacgat ccacgacgac gatgacgcag cactcgacgc gctgctcgac 6840
gccgccgacg acggcctgcg cgctgcggtc gcggcgagcc tggacgccga cgcaggccgt 6900
gccgcgatct tcacccgggc actgccgccc caccgcgacg cgctcccacc ggcggacaat 6960
atgttcggcg gccacaccac gatccactgg gccgatgcga tcgacaccga cccccacgtc 7020
agccggatcc tggagcttct gtccgaggcc ctgaaccgcc tctcggagct gggctgctgg 7080
ctccggaccc cgggcggccc gggaacccca ccgggccgga cggagaccgc cgccaccctg 7140
ctgaccgccc tgtggctggg ggtcaaggaa cggggcgtcg accagcccac cgcccagacc 7200
ttcgtgggcg tcggcctcga cgagatccgt gaactgcgga acgagctgag gaggtccgtc 7260
ggatcggggc ggcagctacg gcccgatccc tgggacagct gggacggcca gtgggccgac 7320
gcccactgtc accggctgca caccaccctg cagaccgccc ggaatctgct cccggacctc 7380
ttccgcgacg gcagcgagac ctcctccgtg cccctgtcga gccgttgaat ccgcggcgcc 7440
gcggtgaccg gaaggcaccc gcgggcccgc ccgtgatcta ctgacaggaa tcggccgcag 7500
cagcggctgc agcggggcta cgacagggct acgacggggg aacgacgcga tgttcggatt 7560
ccgggggcgg cggaacgatc cgccggccga gcgcgccagg ggcgggggcg cggagctggt 7620
cctgccgtcc gccgatccgg tcgagcgggc ggaggcgctg agctggctcc aggagcacgc 7680
gcgcgagtat ctcgaccccg gtgccctcgc cgaccgtgag gatctgcgcc ggtgaccccc 7740
tccgagcggc cggccccgcg ctacctcgcc catacgtcac tggtctggcg gctgcttttc 7800
ggcacggtcg gcggcccctg gcccgagcgg gtcgccgaag ggctcgtgac catctgcccc 7860
gtcacccatg ccgaactccg gcacggtctg caccccggta cggacccctt gcccctgcat 7920
ctggcgctcg accgggcctt cggctccgtc ccgctgaggc acttcgacaa gcagcccgaa 7980
gccgccgacg tgggcaagcg gctgcgcgcg ctcggcgtcg ggcagccgcc ctccctgatg 8040
gacatcgtga ccgcgctcac cgcacgcgac cacggtctga ccctcgtcca caccatcgac 8100
cgcttcgaca gcatcaaccg ggtgtgcccc gatatctccc tgatcaaggt gcaggcggcc 8160
cgccctccgc gccccgagcc ctcccgggac accaaccggc ggcggggctt cctgcgcagc 8220
ctcctggacg actgacccgg ccccaccggc cccgagcggc cctcagcggc ccggaccccg 8280
ccccgaccgg ggcccgcgta cagccgccgg agtccgcggc acgggcagcc cggcggccga 8340
cccgttcccg gacaagggcc ctcccaccgc ccccctaggc atctgtccca tggtcgctta 8400
ggggggtccg gcctgccgtc ctagggggct gacgggccga cgaagccctc cctatgctcg 8460
ggtcgttcgt tacggggaga cggcatcccg gagccgccgc ggccactctt cgaccaccgg 8520
tgggtccggt acgcggcgga cccgtcccct cgtcccgcgc taccgcacct ccatcccgat 8580
catgcccctc ctgtccggcc ggagcatgtc cagcggcatg tccgacggtt ccccctgccc 8640
ggcaggagaa gcgccggccc gagctgtccg ggcgggaccg gcccgggcca tcccgacgaa 8700
aggacgatga catgaccagt ggggtggcgt tcctcttccc cggccaaggg tcgtacgtac 8760
cgggcgtctt cgccggtctg ggtgccgatg ccggccgggt ggcgaccctc gtcgcggaga 8820
tcgacgcggc cgtcgaggag ttccggctga agccggtccg gccgcttctg ttctccccgg 8880
acgctccggc gctggcggag ctgctcgaat ccgatcacga gcggctcgac gtggccatcc 8940
tggcaacctc catcgccctg gcggagcttc tggagtcacg gcacgggatg agtcccgacc 9000
atgtcgccgg gcacagtctc ggggagttcg gagccctcgc cgtcgccggt gtcttcaccc 9060
cgggcgacgc ggccagggcg gtctgcgaac gccacgccac gctgcgcaag gcgccgccgc 9120
ccacgggcgg gatgctggcg gtgaaggcgg acgcggcccg cgccggggag ctgatcgctg 9180
ccgcgcgggc cgggacgtcg gccgtatcgg cgctgaactc ccccagccag acggtgatca 9240
gcggcgcgga agcggatctg gtgaaggtgc agcagctggc acgggaggaa ggcatccgta 9300
cctcccggct gcatgtcccc ggccccttcc acgtcccgca gctggccgac gcgagcgccc 9360
tgtacgcgac gacgatgcgc accatacgga tatccgcgcc ccgggagcgc ttcttctact 9420
cccacggtct gggccgcttc ctgacggcgc aggacgatgt cgtcgacctg atggtgaacg 9480
acatgacccg tccggtgcgg ttccacgact ccgtacgcgc gctgaacgcg gagggcgtca 9540
cgacctatgt ggagtgcggt gcgctggacg tcctcacccg gatcgtgtcc ggatcgctgc 9600
cccgcgccgt gaccctggca ccgctccggg aggccacgac gacaccggat ctgtccgccc 9660
ggctgcggcc cgccggcacc ccggccgtga acggcgtcgc tgcgcccgcg ggcccggcgc 9720
cggccgccga ggtcgacccg gaggtgctcg cgggggtacg tgcggtgtgc gccgaggtcc 9780
tggagtatcc gctggaggtg atcaccgacg acgcggactt ccaggccgat ctcggtgtcg 9840
actccctggc gatgaccgag ctgcaggccc acgcgctgca gcggttcggt ctgaaggaga 9900
cgctgcagga cgcggatacg ggaacgtacg gcacggtttc cggtctggcc gcgtacatca 9960
cgggcctgct gagtgagggc accggttccg tttccgggcg gcggtgatcc ggtcgtgatc 10020
tcccgtgctc cggacgggga ggggccgcac gacgacaggg tcgccgtcgt cgggatgggt 10080
gtcgccgtgc cgggcgcctg cgacccggag gagctgtgga agctgctgtg cggtgacaga 10140
cccgtgttcg atgagccgtc ggaccgcttc cggctcgatt ccttctggtc cgcggatccg 10200
gccgccgagg accgcggcta tgtccgcact tcgggttttc tgcacgactt ccgtccgcac 10260
cccgcactgg ccgcggagat cgcggccgga acgctctcgg ccgccgcgca gaacccggtc 10320
tggctgcggc actgcctgct gcaggcgcgg gacaccgtca ccgcccgcag caccgaccga 10380
tacgcctacc acgtcgggac cagcgccctg gtcggccagc gcaccgacga ggcggtgctg 10440
gccgagtgcg ttccccgggc cgtcgccgag cggctgcacc gcgacgagcc cgcccggatg 10500
gccgaggccg aggcacggct gcgcgccctg ctgagaagcc accacgggta cggcgccgaa 10560
gagccgcggg acacactgcc cgaccgggtc gtacgggccg cggcggccgg actgttaccc 10620
gacgactgcg agttctccgt ggtcgacgcg gcctgctcgt cctcgctgta cgcgatcggt 10680
ctgggtgtcg cgagcctgct ggcgggcgcc tgcgatatcg cctactgcgg cggggtgtcg 10740
ggagtgacgc cgcgttacaa cgtcacgttc tccaaactgc acgggctgag ccccagcggc 10800
gacgtccgcg cgttcgacga cgacgccgac ggaacgctgt tctcggacgg agcgggcgtt 10860
gtcgcgctga agcgcctgga ccgggccgtc gaggacgggg acccggtgtt cggcgtcctc 10920
gtgggattcg gcgggtcgtc ggacggccgg ggaacggcga tctacgcccc caaccccgtc 10980
ggtcagcgcc gctgcctgga ccgcgcccgg caggcatcgg gtctcacggc ggacgatgtc 11040
gactgggtca tcgcgcacgg gacgggcacg gccgtcggtg acgcggtcga gctgcggacc 11100
ctcgccgccg ccaccgatcc gggcagcgtc tggtgcggat ccaacaagtc cctgctcggt 11160
cataccgggt ggagctccgg agtggtctcg gtcgtccagg ccctcacggc gctgcggcag 11220
ggcacgatac cggcacagcg acgcttcacc ggtcccgggc tcaccgcgca gaccggcgac 11280
cgggtacgca taccttcggc ggacgttccc tggcatgcgg gcggccggcg ttccaggacc 11340
gcaggcgtct ccgccttcgg cttcggcggc accaacgccc atctgctgat caccgaccga 11400
gagcccgtgc ggacgggccc gcgccccgcc cgcaccgggc ccgatccggt ggtcgtcctc 11460
gcctggaccg cgcacctgcc cggcgacccc ggccccgagg cgacggagcg gctgctgcgc 11520
gaaggccgca tccccgggcc gcgtaccttc ggcccccgct atccggcgcc cccgtttccg 11580
gacgtccgtc tccctccgcc caccgtacgg tccacggacg cgggccagct catggccctg 11640
cgggtggcgg gcctgttcgc cgccgaacac ggtgagctgt gggcgccggt acgggcgacc 11700
accggggtct tcgcggccgc caccggtccg ccgccgtcct ccatggatca tctggtgcgc 11760
tgtcatgccg ccgacgtaca ccgcattctc gacgaacccg accggacggc gttcaccgaa 11820
tggctcgccg acctgcgggc cacgaccccg gcgaccacca aggacacgct gccggggctg 11880
ctgcccaaca tcatcccggc gcgtatcgcc aaccgctacg acctgggcgg ccccaccatg 11940
ctggtcgaca cgggcaccac cagcgggctc accgccgtgc acaccgccgt ccgccaactg 12000
gcggccggtg ccgtcgacat ggcgctcgtc ctcggtgtca gcgcgaccgg ccgacccgag 12060
ttcgcccgct tcatgggcgt cgcggccgag cggatcgcgg agggggcgtt cctcctcgcg 12120
ctgagtcgcg agtccgtcgc cctcgcgcac ggcctgaccc ccctcgtccg cctccgcacg 12180
gactggaccg gcagccctca ggcgtctgcg gatgccgtcc ccggcgggcc cggtgcggcg 12240
gaggacacct tcctcggcgc cgacggcgtc ctcgccgtga tccgtgccct gcactccacc 12300
gcgtccggcg tcaccgtggg acccgcggac ggcgaaccgg gcccggtgat caccctctcc 12360
cccgccgacg gctcacctct tcggcagaca aggaccagcc gatgacccac gttcgcgacg 12420
ccgcggccac cgacgacccg caggccatcg ccgcctgcga ggtcccggcc ggctaccggg 12480
ccgccgttgt cctcgcggcc gaccaccagg cactcgccgg gagccccgtc gaagaccggg 12540
acccccgcaa gacggtccag gtccaggagg tccccacccc cgaaccggac cacggcgagg 12600
tgctcatcgc caccatggcg agctccatca actacaacac cgtgtggtcg gcgctcttcg 12660
agcccgttcc caccttccgc tttctgcgca ccctcggccg tacctcaccg gaggcggccc 12720
gccacgacca gccgtaccac gtgctcggct ccgacctgtc cggagtggtg ctgcgcaccg 12780
gaccgggtgt acgggagtgg aagcccggcg acgaagtcgt cgcgcactgt ctgcaaccgg 12840
acctgcagac gccgggcggg cacgacgaca ccctgctcga ccccggccag cgggtctggg 12900
gctacgagac gaacttcggc ggcctcgccg aactctccct ggtcaaggcg aaccagctga 12960
tgccgaagcc cgcccatctc acctgggagg aggcggcctc cctgggggtg gcgctctcca 13020
cggcctaccg tcagctggtg tcccaccacg gggcggcgat gaagcagggc gagcgcgtcc 13080
tggtctgggg tgccgccggt ggcgtcggcg cctacgcgac ccagctggcc ctcaacggcg 13140
gcgccgttcc gatctgtgtg gtgtcgtcgc aggccaaggc cgacctgtgc cggcagatgg 13200
gcgcggagct cgtcatcgac cgtgctgcgg agggcttctc gttctgggag gggcgggacc 13260
gcccgcggct gagcgagtgg agccgcttcc gcggtgccgt ccggtccctg gcgggtgacg 13320
acccggacat cgtcatcgag caccccggcc gggacacctt cggcgtcagc gtcatgatcg 13380
ccgcccgggg cggaaaggtg gtcacctgcg catcgaccac cggctaccag cacacctacg 13440
acaaccgcca tctgtggatg cgcgtcaaac gcatcatcgg gtcacatatg gcgaactacc 13500
gggaagcctg ggccgcgaac gaactcgtcg cacgcggcag catccacccc gtgctctccc 13560
gggtctaccc cctcgacgcc acaggcgacg ccacgcacgc cgtcgccaac aacagccacc 13620
acggcaaggt gggcgtgctc tgcctcgccg accgccccgg catgggagtg cgcgaccccg 13680
agctgcgggc ccggaaactc gacagcatca acctgttccg gaaggggcag ccccggtgag 13740
cgaatccgaa cgcctcggta tcgtcaggga tttcgtcgcc cgggagatcc tgggccgcga 13800
aggcatcctc gactcgctgg cggacgcacc actggccctg tacgaacgct tcgccgagac 13860
gggcctgatg aactggtggg tccccaagga gcacggcggt cttgggctcg gcctggaaga 13920
gagtgtgcgg atcgtctccg aactcgccta cggggacgcc ggggtggcgt tcaccctgtt 13980
tctgcccgtc ctgacgacca gcatgatcgg ctggtacggc agcgaggagc tcaaggagag 14040
attcctcggc cctctcgtgg cccggcgggg cttctgcgcc acgctgggca gcgagcacga 14100
ggccggcagc gaactggccc ggatctccac cacggtccgc cgtgacggcg acacgctggt 14160
actcgacggc accaaggcct tctccaccag caccgacttc gcccggttcc tcgtcgtcat 14220
cgcccgttcg gcggacgacc cggcccggta cacggcggtc accgtaccgc gggacgcgcc 14280
ggggctgcgg gtcgacaaac gctgggacgt catcgggatg cgcgcctccg cgacctatca 14340
ggtgtcgttc tccgactgcc gggtgccggg ggacaacgcg ctgaacggca atgggctgcg 14400
gctgctggag atcggcctca acgccagcag aatcctgatc gccgcatccg ctctgggtgt 14460
cgcccgcagg atccgcgatg tgtgcatgga gtacgggaag acgaagtcgc tcaagggcgc 14520
tccgctcgtc aaggacggcg tgttcgccgg gcggctcggc cagttcgaga tgcagatcga 14580
cgtgatggcg aaccagtgcc tggcggccgc acgggcctac gacgcgaccg cggcccggcc 14640
cgacgccgcc agggtgctgc tgcggcaggg cgcccagaag tcggcactga ccgcgaagat 14700
gttctgcggg cagacggcct ggcagatcgc gtccaccgcg tcggagatgt tcggcggcat 14760
cgggtacacg cacgacatgg tgatcgggaa gctgctgcgg gatgtgcggc acgcttcgat 14820
catcgagggc ggcgacgacg tcctgcgcga tctcgtctac cagcgcttcg tcgtccccac 14880
cgcgaaacgt acctagggca tgttctggtc agtcccgcgt cagggcctgg gtgaggtcgg 14940
cccacagatc gtcgacgtgt tcgaggccga cggagatccg gagcagtcgg tcggagatac 15000
cggcctgttc gcgtgagccc gggtccatgg cgtggtgggt gagcgagacc gggtgctgaa 15060
tgaggctgtc gacgctgccg aggctgaccg ccggggtgaa gagacgtacg ccgccggtca 15120
ccgcgtgcgg atcgtcgacc tcgaaggaca cgattgcccc gcctgcggcc atctgcttcg 15180
gcggccgggg ttcaccgctc agccccgggt agtggaccct ggtgaccgcc ggatggtgca 15240
ggagccggcg ggcgatctcg gcagccgagg ccgaagcgtg gtgcatccgc accgagagcg 15300
tcgacagtcc tctgaggagc tggtagccag ccagggggtg caggatccct ccggtggcga 15360
accggatccg ccgcagggca cgggcgaact cctcgttcga cgccaccaca ccgcccatga 15420
cgtcaccgtg gccccccagg tacttcgtcg cgctgtgcag aacgatggcg gcacccctgt 15480
tcagggggcg ctggagcgcg ggcgttgcga aggtgttgtc gaccagtacc ggaaccggag 15540
cgcatgcagc ggccagcgcc tggatgtcgg tctccgtcag tgtggggttg gcgggtgact 15600
cgacgatcac cagccccgtg tcgctgcgga tggcatcgcc ggcgctgtgg ggttgcgccc 15660
aggtcaccga ggtgcccagc aggcccgagt ccaggaggta gtcgctggtg ccgtacaggg 15720
gacggacggc gacgatatgc ggccgtcccc gggcgacctg cacgagaagg caggcgcaga 15780
gcgctgccat accgctggcg aaggccaccg cggcttcggc cccttccagt tcggccagcg 15840
cggactcgaa ccgtgcgacg gtggggttcc ctgcccggcc gtagatcggc ggaccgccgt 15900
cgtcggctcc ggagccgaac acgtcgatcc gcgccgcctc ggcaacggtg tcgcgggagg 15960
ggtaggtggt ggacaggtct atgggcggga catgcagtcc gagatcgaca agatcctcac 16020
ggccggcatg gaccgcccgg gtttcccagt gatgcgaagg catgacgaca gtcttcgcaa 16080
agcgtcagga tcagtgactg aatctcgcac tacattcggt ccatgaaaga aaaggttgtc 16140
ctggattcga tagatcaggc aattctgcgt gagctgcaga atgatggtcg gctgcccaac 16200
aagacgctgg cccggagggt cggcgtggca ccgtccacct gtctggcccg cacgcagagg 16260
ctgatggagg caggtgtgat cagaggtttc caggctcagg tgagtgccgc ggcgatcggc 16320
cggcaggtcc aggccgtcct cgccgtccag ttcatcgccc attcacgtcc ctttgtcgac 16380
ccgttcgtgg catgggccag ggagcggccc gagactcgtg cgcttcacca tgtgaccgga 16440
gccttcgact tcctcgtcca cacggcctgc cgtgacaccg agaacctcca gcaactcgtc 16500
ctggagttca ccgcacgccg agaggtgggc cgagtggaga cccacctcgt attcggatcc 16560
tggtcgggag gacccctgac tccgggctag tgatctgaat cggagattcg tcggcaggtc 16620
gggcgggcgc cgatgtcccg ccggtacagt cgccaccgtc gttccatcca ccctctgtct 16680
ccaaggagac ctcgtggacc gagaacccgt tttcgtcctc gacccgcgcg gcggcgatcg 16740
ccatggcgag gacgccgccc tccgcgcccg cggccccctg acccgagtcg acgccctcgg 16800
cgtggaggcg tggtcggtca ccgacccggt gctgctccgt cggctgctgc tggactcgcg 16860
ggtctccaaa aacgcccggc aacactggcc cgccttcccg gaggagatcg tcggagtctg 16920
gccgctcgcc ctctgggtcg ccgtggagaa catgttcacc gcctatggcg aggagcaccg 16980
acggctgcgg cggaccatcg ggccggcctt cgccgcccgc aggatcaacg cgctggcgcc 17040
ggtcatcgag cagctcgtgg gggagctgct ggacgagctc gccgccaccc cgcccggaga 17100
gccggtcgac ctgcgggagc acttcgccta tccgctgccc atcggggtcg tcggccagct 17160
cgccggcctc cccgaatccg tccggccccg gttccgccgt accgtcgacg tgatcttctc 17220
caccagccac agccccgagg agacgaccgc cgcggtccag gatctgtacg cgctcctcgc 17280
cgacctcgtg gccgccaagc gcgccgagcc gggagacgac ctcacgtcgg cgctcatcgc 17340
cgccagggat acggaaggcg acggagagcc cctgacggag gccgaactcg tcgacaccct 17400
gctgctggtg gtcaacgccg gtttcgaaac caccgtcaac ctcctggacc aggcgatcac 17460
cgcactcctc accgaccccg ggcaactcgc ccatgtccgc gccggacgcg cgggctggaa 17520
ggacgtggtc gaggaatcac tccgccacga ggccccgctc gcgcatctgc cgatgcgctt 17580
cgccgtggag gacatccccc tccccgaaca cggcgtgacc atccggcagg gcgacgccgt 17640
cctgcccgcc tacgccgccg ccaaccggca tccggacctg cacggcctca ccgccgacga 17700
cttcgacgcc acccggagcg acaagagcca tctctccttc ggacacggca tgcacctctg 17760
cctcggagcc gccctcggtc gcctcgaagc cgaaatcgcc ctgcgcggcc tcttcgaacg 17820
cttcccccgt ctcgccctcg ccgtgcccct ggaccgactg cgccccaagc cgagcttcat 17880
ctccaacggc cacagcgaac tgcccgtcat catcgacccg tagcccccgg ccgacggcag 17940
ggatgtccgc tctcaacagc acggggatac tctgatgaac cgcttcgcct cggacgaggg 18000
gctggacgac agagtcgcct actgactgcg aaggacttgg aagcacaccg agccgccgcc 18060
ccctccgccc cgtaccgggg cggcacgacg aaagggcagg gacgactgtg ggcactcctc 18120
aacccgatgt cgccgagggc ctcacgccgg tcgaggcggc gcgctcactg gtcccgctgc 18180
tcgctgccga agcggcccgc accgaggagc ggcgcgccct caccggcgcc actgtgaccg 18240
gcctgcgccg ggccggtctg ctccgcctcg ggaccccgac cgagtgcggc ggccggggtg 18300
cgggtgcccg taccgcggtg gatgtgtgcg aggagctggc caagggctgt gcgtccgcct 18360
cctggatcgt gggcatcgcc tacggcggcg ccctcttcgc ctcccagctt ccccactccg 18420
agcgtgcggc cctgtggcgg gacgacccgg acgctgtcgt ctgcggcagc gccaacccgt 18480
ccggaacggc gcggcgtacg gacggcggct ggaccctgag cggccgttgg ccctggatct 18540
ccggcatcca ccatgcgccc tggaccctgc tcggcttcgt ccggcccggc gcagggggcg 18600
aaccggagcg cggcatggcc gtggtcccca ccgccggcct gaccgtcgag gacgtctggc 18660
atatggcggg catgcgcggc accggcagcg acacggccgt cgcggacggc gtgtacgtgc 18720
cggactcccg cacgatctcc ctgaccgcca tggcggacgg cgcctaccgg cgacgccatc 18780
ccggcgaacc ccgggtcacc ttccatctct ccatcaacct gccgttggtg gcgacggccg 18840
tcgggatcgc cacagcgtcc ctggagaagg tgctggatgc cgcggcccgg ggcaaacaga 18900
cggtctcccc gctgcaccgg ctggtcgccg aggactccgc ccatcagctc aatgtggcgg 18960
acgccgcgac gctcatcgac acggcccggc tgcatctgcg ccgcgccgcc gacgaggtgg 19020
actcccacgc ccgcgcgggg cgccgtcccg cgctcgccga gcgggcccga ctgcggatgg 19080
acgccgccca cgccatgcgc tgcgcccgcg acgccgtgag cctgctgctg gacaccgcgg 19140
gcgcgggcag cttcgcggac ggctcggtcc tgcaacgggc ctggcgcgat atcgagacgg 19200
cgtcccggca cgccgcgctc agcgtccaga ccagcaagga gatatacggc cgcgctctgc 19260
tcggcgcccc gctgccgccc ggcccggtcg tctgaggggg gccgacgatg acgacggcag 19320
gcctccgggt ggcgctggtc accggcgcgg gacgcggtat cggggccgcg atcgccgaac 19380
ggctgcacgg gtccggccac cgggtggccc tgctggaccg cgacggcgac gccgtgaccg 19440
ggctgtccgc cgccctcgac cccgccggcg cgggcaccgc gctgccgctg cgtgcggacg 19500
tcgacgacac ggacgccgtc cacgccgcgc tgcgcgagac cgccgccgcc tggcacgcgc 19560
ccgacatcct gatcaacaat gccgcccgga ccgcccccgg ctcggtatgg gacatcgaac 19620
cggacgaatg ggacgccgta ctgacgacca atctgcgcag cgtcctgacc ctgacccggc 19680
tgtgcgcgcc cgcgatgcgc gaccgcggct ggggccgggt ggtcaacctc tcctcgctgg 19740
ccggtcagca gggcggcacc ctcgccggcg cccactactc cgccgccaag gcgggcgttc 19800
tcgtgctgac caaggtgttc gcccgtgaac tggcggcgca cggcgtgacc gtcaacgcgg 19860
tagccccggc cgccgtcgac accccggcgg tcgccgggct cggcccgtcg gcggtggccg 19920
aggcggcccg gcagatcccg gtgggccgga tggggaggcc ttcggaggtc gccggcctcg 19980
tggcctatct ggtgggcgaa gagggcggat acgtcaccgg cgccaccttc gacatcaacg 20040
gcggcaccca tatgcgctga cgcggccccg cgccctgcga tcgcgatgcc gcccccgagg 20100
cgccgctgga ccgtgtggtc ccgggtgggt cccggcgccg caccgctacc cccctcccca 20160
cccccctgga cccccctgac ccgggggtcc gggccgggag ggggacggga cgcccgccta 20220
gcattccggg catggcgaat caggtgacca tgtccgacgc gctgctcgct tacgtccgga 20280
aggtgtcact gcgggacgac agggtgctgg gcggtctgcg ggcggagtcg gcagggctgc 20340
cggggggcaa cgctctgccg gtatccgccg aagagggcca gttcctggaa ttcctggtgc 20400
ggttgaccgg cgcccgtcag gtgctggaga tcgggacgta caccggctac agcaccctct 20460
gtctggcccg cgggctgccg cccggggccc gggtggtgac gtgcgacaac acggcgaagt 20520
ggccggaggt gggcaggccg tactgggagc gggccggggt ggccgaacgg atcgacgtac 20580
ggatcggcga cgccctggac gtgctggccg gactccgcga cgagccgggc gcgggaccgg 20640
ggtcgttcga tgtcgtgttc atcgacgccg acaaggaacg ctatccggcc tactacgagg 20700
cggctctgcc gctggtgcgc ggcggtggcc tgatcgtcgt cgacaacacg ctgttcttcg 20760
gacgggtggc cgacgacgcg gtgacggacc cggagacgac agcgatccgc gcactcaatg 20820
cggggctgcg cgacgacgat cgggtggacc tggccatgct ggcgtcggcc gacggcatca 20880
ccttgttgcg gaagcggtga acgggatact gcccgcggcg gtcagtgtca gggtcctcgg 20940
cccgggtcgc ggcgagggct ccagatgcag ccgttccaca ccaccggccg gctcccccag 21000
cggcgacgcg caggcgcagc cgctctccat gaacccggcg aaccggtagg cgacctccat 21060
cagacggttg cgttccgtgc gccggaagtc ggccatcaga tggacgccgg cccgggcggc 21120
ccggtccgtg agccagtcga ggatcaccgc accggcaccg aacgacacca cccggcagga 21180
cgtcgcgagc agcttcaggt gccacacctg cggttgcgtc gcgagcagga cgatgccgac 21240
ggcgccgtgc gggccgaagc ggtcgcccat ggtgacgacg aggacctcgt ggccggggtc 21300
tgcgagcagc gcccgcagtg ccgcgtcgga gtagtgcacg ccggtcgcgt tcatctgact 21360
ggtccgcagc gtcagctcct cgacgcgggt gatctcctcg gggcccgcgg gcgcgatcgt 21420
cattctcagg tccagggagc gcaggaagtc gtcgtcgggg ccggaccagg cctctcgtgc 21480
gtggtcacgc gcgaatccgg cctggtacat gaggcgtcgg cggcgtgagt cgaccgtgga 21540
ttccgggggg ctgaactcgg gcagggtggg gagcgcggtc acctgctcgg ctgcgtagca 21600
gcgcacttcg gggagatgga acgcgacctc ggcgcgctcg gcgggctggt cgtcgacgaa 21660
ggcgagcgtc gacggggcga agttcagcct ttcggcgatg gcccggacgg attgcgattt 21720
cggcccccat ccgatgtgcg gcagaacgaa gtactcggcc atgccgagcc gttcgaggtg 21780
cttccaggcg aggtcgtggt cgttcttgct ggcgaccgcc tggagaatgc cgcggccgtc 21840
gagtgcgcgg acgacgtcgc ggaccgcgtc ggtgagtacc acgtcggcgt cttccagcac 21900
ggtgccgcgc cacaaggtgt tgtccagatc ccagaccagg catttgacga tggtcgtggt 21960
ggtcatggcc gtcctctcag gccgggaggg ccagcgcgtg ccgcgcgagc atcatccggc 22020
tcatctcgct gctgccttcg atgatctcca tgagcttggc gtcgcggtac gcccgctcga 22080
cgacgtgtcc ttcgatcgct ccggccgacg cgagtatctg tgcggcgagc gcggcgcccg 22140
cggcggcccg ctcggcggcg acgtgcttcg ccaggaccgt cgcggtcacc gcctcgggtg 22200
agccctcgtc ccagaggtcg ctcgcgtgct cgcacacgcg cgccgcgatc tgctccgcgg 22260
tccacaggtc ggcgagatgc ccggcgacga gctgatgtcc ggcgagcggt tgcccgaact 22320
gttcccggct cttcgcgtgg gctgtcgcgg cggcggtgca ggcgcgcagg atcccgaggc 22380
agccccaggc gaccgaggtg cggccgtacg cgagtgacac cgcgacgagc atcgggagcg 22440
acgccccgga gccggcgagg accgcgtccg ccggtacccg tactccgtcg aagtacaggt 22500
gggcgtggcc cgcggcgcgg catcccgacg ggttcgggac ccgttcgacc cgtaggcccg 22560
cagtgtccga cggcacgacg acgaccgcgc cggagccgtc ctcctgcagg ccgaagacga 22620
ccaggtggtc cgcgtacgcg gccgcggtcg tccagacctt gtggccgtcg acgacggcgg 22680
tgtctccttc gatccgcacc cgggtccgga tcgccgacag atcgctgccg gcctgccgtt 22740
cgctgaagcc gacggccgcg agtttcccgc tggtcagctc cttcagatag gtctcgcgct 22800
gggcggtgcc gccgatcctc agcacggtcc aggcggccat tccctgcgat gtcatgacgc 22860
tccggagtga gctgcagaga ctgccgacgt gcgcggtgag ctcgccgttg ccgcggctgc 22920
cgaggccgag gccgccgtac ccggcctcga cctccgcgca gagcaggcct tcggcgccga 22980
gccggacgag gaggtcgcgc ggcagttcgc cggagacgtc ccagccggca gcccggtcgc 23040
ccacgagccc ggtcagcagc gcctggtgat caggcatcgc cggtccgcag ccggtggacg 23100
aggccgacca tggacacgac gctgcggtag ttcacgagct ggaggtcggg tccgctgatg 23160
gtgatgctga acgtcttctc caggaagacc accagctcca gggcgaacag cgacgagagg 23220
cctccttccg cgaacaggtc gcgctccacc gaccagggcg atccggtctt cttctccagg 23280
aatgcgacca gctcgtgggc gacggggtcg tctgtgacgg gaacggtcac cggaacacct 23340
cttcgtaggg gtagaagcca cgcccggtct tccggccgtg gtgcccgtcc cggaccttgg 23400
tgaggagcag gtcgcaggga cggctgcggt cgtcgccggt gcgcttgtgc agcacccaca 23460
gcgcgtcgac gaggttgtcg atgccgatga ggtccgcggt gcgcagcggg ccggtcgggt 23520
ggccgaggca gcccgtcatc agcgcgtcga cgtcctcgac ggacgcggtg ccctcctgga 23580
cgacccgcgc cgcgtcgttg atcatcgggt ggagcagccg gctcgtgacg aaaccgggcg 23640
cgtcgcggac gacgatcgcc ttgcggccga ggaccgcgag cagatccgcg gcggcggcca 23700
tggccgcctc cccgctgcgg ggcccgcgga ccacctcgac catcgggatc gcatacgacg 23760
ggttcatgaa gtgcgtgccg aggaggtcct gcggccgggc cacggcgtcg gccagctcgt 23820
cgacggggat cgacgacgtg ttcgtgatga tcggggtgcc gggcggcacc gccgccgaga 23880
cggcggcgag gacctgtgcc ttgaccgtcg cgtcctcgac gacggcttcg atcaccgcgg 23940
tggcagtgcc gggctcggtc cgcgccgatg tcaccgttgt cagctcgccg gggtccgcct 24000
cggcgggacc cgtcaggagg tgcgccatcc gcagctcggc ggcgatccgt ttccgcgccg 24060
ccgccagaat ggtctcggac gtgtcgacga gtgtgacgtg gacgccgtgg cgcagcgcga 24120
gcgtggtgat cccggtgccc atcactcccg cgccgaggac gaggatccgc cgttccgttc 24180
cgcttccccc ggccggcgtc accacggcag cgagtagggg tcgaggacgt cgtccggtgt 24240
cgccccgatc gcggctttgc ggccgagacc gagttcatcg gcgaagccga gcagtacgtc 24300
gaacgcgatg tggtcggcga aggcgctgcc ggtcgagtcg aggacgctca ggctgccgat 24360
gtacgcagcg gcggtgcggg gcgccgcgca gaggctcgcc agcgacggtc cgagcgggcg 24420
gtcgggcagc tgctggaatt cgccttcggc acgggcctgc ccggggtggt cgacgcagat 24480
gaacgcatcg tcgagcaggg ccttcggcag ctcggtcttg cccggctcgt cggcaccggt 24540
cgcgttgacg tggaggtgtg ccaggcgcgg ctcggcgggg agcaccgggc cctgtcccgc 24600
gggcaccgat gtgacggtgc tcaggacgtc ggcggcggcg accgcttcgg cagggccggt 24660
gatttcgacg gggagcccga ggaaggcgat ccggcccgcg aaggacgccg cgtgcgccgg 24720
gtcgatatcg ctgaccagga tccgctcgac gggcaggacc ctgctgagtg cgtgtgcctg 24780
ggtcaccgcc tgtgcgccgg ctccgatcag cgcgagggtg gagctgtcgg gtctggccag 24840
cagccggctc gcgacggccg agaccgcgcc cgtgcgcatc gcggtgatca cacccgcgtc 24900
ggcgagcgcg atcagactgc cgctgtcgtc gtcgaggcgc gacaccgtgc cgacgaccgt 24960
cggcagccgg aatcgctgat agttgtgcgg actgtacgaa acggtcttca tggtcacggc 25020
aacaccgggc acccggtacg gcatgaactc gatgacgccg gggatctcgc cgctccgggc 25080
gaagccactg cgtggcggcg cctcggcgag ctctccccgg ccgagcgcgg cgaagccgtc 25140
gtacagctct tggatcagcc ggtccattat cgtgtcgcgg ccgaccacgg agaggatctg 25200
cttgatatcg cgctgacgca ggatcttggt ctgcatgggt caccctcctt tcctggtcag 25260
ggttgttgtc tctgtggtcc gagcgtcgtg gtggtgttct tcgccgcggc ggccgggcag 25320
gtggctgccg tacgtctcat cgcagctccc ggtcgatcag gtcgaagatc tcgtccgcgg 25380
tcgcctccgc ggacagcacg ccggccggtg cggccgggtg ggccgcgcgc tgccagcggt 25440
cgagcagggc ggcgattcgg gtcccgatcg gatcggctct gcggtcgccc gggtcgacgt 25500
ctgcgaccag cgcctccagc cggtcgagct gtgcgagtgc ggcggtcgcc gggtcgtccg 25560
gggagaggag ttcgccgatg cggccggcca gcgcgcgggg cgtcgggtag tcgaagacga 25620
gggtggcggc gagcttcaga ccggtcgctt cgttgaggcc gttgcggagt tggaccgcga 25680
tgagggagtc gacgccgagc tcccggaagg ccgcgtcctc ggggatgtcg tccggccctc 25740
cgtgtcccag cagggctgcg gccttctgcc gtacgagcgt gagcagatcg cccgtggggt 25800
cctcgtcgcg ggtgacccgg cggggcaccg gcttggggcg tccgcgcagc agtggcagat 25860
ccgaggggag ttcaccggcc acggcgacga cactgcccgt gcccgcccga acggctgcct 25920
cgtacatgcg catgccctgc tccgcggtga gtgcgctcgc ccctccccgg cgcatgcggc 25980
gccggtcggc gtcggtcagc ccgccggtca gacgggtcgc ctggtcccag aggccccagg 26040
cgatggacag cgccggcagc cccagagtgc ggcggtgttc ggcgagcgcg tcgagaaagg 26100
cgttggccgc ggcgtagttg ccctgcccgg gagtcccgag cacgcccgcc gccgacgaat 26160
agaggacgaa tgcggcgagg tcggtgttgc gggtgtggtg gtggaggtgc caggcggcgt 26220
cggctttggg ctggaggacg gtgtggatgc gggtgggtgt gaggtggtcg atgagggtgt 26280
cgtcgagggt ggccgcggtg tggaagatgc cggtgagggg ttggggtatc tggtggaggg 26340
cttgggtgag ttggtggggg tcggtgaggt cgcaggggat gtgggtgccg ggggtggtgg 26400
ggggcggtgg tgttcgggag aggaggtagg tgtgggggtg gtcgaggtgg cgggcgagga 26460
ttccggcgag ggtgccggag ccgccggtga tgacgatcgc gccgtcgggg tcgagcggcc 26520
gcggcaccgt gagcaccagc ttcccggtgt ggtcgccccg gctcatggtc gccatcgcct 26580
cgtgagcctg ccgcatgtcg tgaacggtca cggggagggg gtggagggtg ccttgggcga 26640
agaggtcgag gagtcgggtg atgatctgct ggaggtggtc gggtccggcg tccatgaggt 26700
cgaagggctg ctggatgtcg tggcggaggt cggttttgcc catctcgatg aagcggccgc 26760
cgggtgcgag gagggcgacg gaggcgtcga ggagttcgcc ggtgagggcg ttgagtacga 26820
cgtcgacggg ggggaaggtg gtggcgaacg cggtgctgcg ggagtcggcg gtgtgcgggc 26880
cgtcgaggtc caggagatgc tgcttcgcta tggaggcggt ggcgtagacc tcggcgccca 26940
gatgccgggc gatctggacg gctgccgcgc ccacaccggt ggccgccgcg tggatcagga 27000
ccttctcacc gggccgcagc cccgccagat ccaccaggcc gtaccacgcc gtcgcgaaca 27060
cggtgaccac ggacgccgcc tgcggaaacg tccatccctc cggtatccgg cccagcatcc 27120
ggtgatcggc gacgaccgtg gggccgaagc cggttccgac cagaccgaag acccggtcgc 27180
cgggtaccag atcgtgcaca tcggggccgg tctccaggac gatccccgcg gcctcgccgc 27240
cgagcacgcc ccggccgggg taggtaccga gcgcgattag cacgtcgcgg aagttgagac 27300
ctgccgcgcg gactgcgatc cggacctcgg tgggggccag cggccgccac ggttctgccg 27360
aatcgacggc agtgagtcct tcgagggtgc cggtcggcgc cggccggatc agccaggtgt 27420
cgctttccgg gacggcgagc ggctccggca ccctggtgag gcgggccgcc tcgaagcggc 27480
cgcggcgcag gcggagtcgc ggttcgccca gggcgacggc gatctgctgc tgcccggtat 27540
cgagtgttgc gccgggtgcg gtttcgacgt ggacgaagcg cccgggctgt tcggcctggg 27600
cggtacggag gaggcctgcg gccgcggcgg tggcgagccc ctcggtggtc tgcacgagca 27660
gggtgcggtc ggtgccggtc agggcctcca gcaggtgggc cgtcaacgca cgtgtctcgg 27720
ccgtcgggtc gtcgtcggcg gcgtgcaagg tgatgacgtc cacatcggtc atggggacgt 27780
ccgcgggtac ggcgggctcg gtccaggtca gtcgcatgag gccggtgccc acgggcaggg 27840
acagcggacg ggtgcggatc gtccggattt cggcgaccgg tcgtccggtg gagtcggcgg 27900
cccgcaggct cagctcgtcc ccgtcccggg tgaccgcgac ccggagcgcg gctgcgccga 27960
cggcgaccag ccgggctccg gtccaggcga acggcaggtc ggcggtgctg ccgtccggcg 28020
cggtcagggc gacgatctgc agggccgcgt cgagcagggc ggggtgcatg ccgtagcggg 28080
gtgcctcggc agcctgttcg tcgggaaggg cgacatccgc gtagagggtg tcgccgtcgc 28140
gccaggccgc gcgcaggccg cagaaggccg ggccgtagcc gtaaccgact gcggcgagtt 28200
cctggtagaa gccggtgatg tcgacggcgt gcgctgccgg tggcggccac gcggacgggt 28260
ccgccgccac ggtggtaccg gtggtaccgg tggtggtgag ggttccggtg gcgtggcggg 28320
tccaggtgtc ggttccttcg gggcgtgcgt ggacggtcac ggggcggcgt ccggcctcgt 28380
cgggccggtc gacggtgacg gtgaggtcga cggctccggt gacgggcagg gcgagcggtg 28440
tttcgatgat cagctcgtcg atggtgtcgc agccggtctc gtcaccggcc ctcagcacga 28500
gttcgagtag tgccgtgccc gggagaagta ccgtgtcctg gaccgtgtgg tcggccagcc 28560
aggggtgcgc ggcgagtgac accctgccct tcagcaggac gctgtcgctg cccggcaggg 28620
ccaccacgct cgacaggaac ggatgcccga tgccctcgct gccgcctgcc ggggcgggag 28680
gcagccagta gcgcttgtgg tcgaaggggt aggtggggag gtcgaggagc cgtaccccgg 28740
tgggcgggac gacggtcgtc cagtcgacgg ccgcgccctg aacccaggct tcggccaggg 28800
cggtggtgaa ccggtctccg ccgccgtcgt cggtgcgcag ggaggcgacg gtacgctcct 28860
ggtcgatggc gggcagcagc acgggatggg cgctgcactc gatgaaaagg gagccgtcga 28920
gttctgtgat ggcggtgtcc agggctaccg gttgacggag gttgcggtac cagtagccgt 28980
cgtcgaccgg tccggtgacc cagccgctgt cgacggtgga ccaccagggg atggtggggg 29040
tccgggccgt aataccggtt aatgcttcgg ccagttcgtt ctcgatggcc tcgacgtggg 29100
gggtgtggga ggcgtagtcg accgcgatcc gccgaacccg tacccccgca gtttcgtacc 29160
gggccaggac cccctccacc gcctgcgcat ctcccgcgat cacggtcgac gacgggccgt 29220
tacgggccgc gatccacacc ccctccaccg tctcgatgtc ggcggcgggg agtgcgaccg 29280
atgccatcac cccccgcccc gccagccggg caccgatcac ccggctccgc aaagccacca 29340
cccgcgctcc gtcctccagg ctcagcgcac ccgccacaca cgccgcagca atctccccct 29400
gcgaatgccc caccaccaca tccggcacca caccatgcga cccccacaac ccggccagac 29460
tcaccgccac cgcccacgac aacggctgca ccacctccac agccccggaa tcgtgccgcc 29520
cggccagcac ctcacccaga tcccagcccg tgaacggctt caacgccgcc gcacactcac 29580
ccatccgccg ggcgaacacc tccgaccacc ccatcaactc cacacccatt cccacccact 29640
gcgacccctg ccccgggaac acgaacaccg tccgcaaccc ctcacccgcc acacccataa 29700
ccctgctctc ccccaacagc accgcccgat gaccgaacac cgcacgcccc cgcaccaacc 29760
catccgccac cacccccaca tcacacccac cccccaccaa cccacccacc cgctccacca 29820
acacacccac acccacaccc gaacgagccg acaccggcaa cggcaacaaa ccaccggacg 29880
actctgtggg agagaccgaa acctccggca ccccctccaa aatcacatgc gcattcgtcc 29940
cgctcacccc gaaccccgac acccccgccc gccgcgcacg ccccgactcc ggccacggcc 30000
tcgcctccga caacacctcc accgaccccg ccgaccagtc cacatgcgac gacggctcac 30060
cgacgtgcaa cgtcctcggc aacaccccgt accgcatcgc catcaccatc ttgatcacac 30120
cggccacacc agccgccgcc tgcgcatgac caatattcga cttcaacgaa cccaaataca 30180
gaggcacctc acgcccctgc ccatacaccg caataaccgc ctgcgcctca atcggatccc 30240
ccagcaccgt ccccgtccca tgcgcctcca ccacatccac atccgcagga cccaaccccg 30300
cccgctccaa cgccccacga atcacccgct gctgcgccgg accattcggc gccgacaacc 30360
cattcgacgc accgtcctga ttcaccgccg aaccccgcac caccgcaagc accgaatgac 30420
catgacgctc cgcatccgac aaccgctcca ccaccagaac accgacgcct tccgcccagc 30480
cggtgccgtt cgcggtgtcc gcgaacgctc ggcagcggcc gtcgggagag agtccgccct 30540
gttgctcgaa ctcgacgaac ccgtccgggg tgcccatcac cgtgaccccg ccgaccagcg 30600
ccagcgagca ctccccttgg cgcagggcgt gccctgcctg gtgcagggcg accagcgacg 30660
acgaacacgc cgtatcgacc gtcaccgccg ggccctggaa gccgtagaag tacgagatac 30720
ggccggtgag gacgctgggc tgtacgccca gggagccgaa tccgcccagg tcggcgcctg 30780
ctccgtagcc gtacgagaag gtacccatga acacgccggt gtcgctcccc cggagcgttt 30840
tcggcacgat gcccgcgtgc tcgaacgcct cccatgacgt ctccaggacc agacgctgtt 30900
gcgggtccat cgtcagtgcc tcgcgcgggc tgatcccgaa gaacgcggcg tcgaagtccg 30960
cggcgtcgga gaggaagccg ccccggtccg cgtccgccct gccgcccagg acggtcgggt 31020
cccagccgcg gtcgacgggg aagccgctga tcgcatcgcc gccgctgtcc accagccgcc 31080
acaggtctgc gggtgatgtg acgccgccgg ggagacggca ggccatgccg acgatcgcga 31140
ggggctcgtc accggtcgcc gcggtggcgg gccgtgcggt cggccgggcg ggggcggcgc 31200
cggtcagcgt gtcgttgagc cgggacgcaa cggcccgcgg cgtcggatgg tcgaaggcga 31260
gggtggcggg cagccggaca ccggtcgccg cggcgagccg gttccgtagt tcgacggcgg 31320
tcagcgagtc gaccccgaga tccttgaacg ccgcatccgc gggcacgtcc gcggcgtccg 31380
cgtggccgag cacggccgcc gcgcagtcgc ggaccagggt gagcagcgcg gcgtcccggt 31440
cggtgcgggc catggtcgcg agccgttcga caagcggaac accggtggcg gccgtccggc 31500
gtggcgcggg gcgccgcagg ccggcgaaga gcggcgaggt ctgcgcgttc aggtccatgg 31560
cggccgccac ggtgaacgcg gcaccggttc cggcggcggt ctccagcagg cgtagcgcct 31620
ggtcgccctg catggggcgg aatccgccgc ggcgcacgcg ggtccggttg gtgccgctca 31680
tactgccggt gagtccgctg tcgtcctccc agagacccca ggccagcgac agcgcgggca 31740
gcccttcggc ccggcgctgg gcggcgagtc cgtcgaggaa gccgttggcc gcggcgtagt 31800
tgccctggcc gcggccgccc agaaggcccg cgacggacga gtagaggacg aatgcgcgca 31860
ggtccgcgcc gcgggtcagc tcgtggagat gccaggcgcc gtcggccttg ggtcgcagcg 31920
cggtggcgag ccgttccggg gtgagcgcgg tgaccacgcc gtcgtcgagc accgccgccg 31980
tgtggaagac ggcggtcagc ggccgctcca cggcggcgag tacggcggcg agccggtccc 32040
ggtcggagac gtcgcagcgg acgtgaacac cgggtgtgtc cggtggcggt tcgctgcggg 32100
agaggagcag gaggtggcgg gcgccgtgtt cggtgacgag gcgccgggcg agaaggcccg 32160
ccagtacgcc cgagccgccg gtgatgacca ccgtgccgtc ggggtccagc agtggcccgt 32220
ccggctgcgc gggcgctgcg gtgcgggtga gccggggcac ttcgtaccgg ccctcggtga 32280
gacggacgta cggttcggcc agtgtcacgg ccgcggccac tgcctcgtcc ggggtgtcgg 32340
cgccggtctc caccagcacg aagcgtccgg ggtgctcggc ctgtgcggag cggacgagac 32400
cggcgaccgc tcccccggtc ggtcccgcgt cgatgcggac gaccaggggg gtcgtctccg 32460
cgaggctttc gtcggcgatc acccggtgca gctcaccgag caccagttcg gtgagccggt 32520
acgtctcctg gagcacatcc gcgcccggct tcgggagcgc cgagacacag ggggccgggc 32580
ccgcgggccc ggggcgggtc tccgtcccgg gtgcacggtt cagggtgggc gcggggggcg 32640
gcagctcggt ccaggagagg tcgtacaggg agttgcgggc cgcggcgtcg ccgtcggtga 32700
gtgtgctggt gtcgaccggt cgtgcggtca gttcggagac ggtcagtacc gggtgaccgg 32760
ccgggtccgt cgcgtgcacg gtcacaccgt tcgggcccgg gcccggggtg atcgcgacgc 32820
ggagcgtggt ggcaccggtc gtgtgcatcc gcacgccgtt ccacgagaac ggcagcttca 32880
cctctcccgg atccgattcc tgccctgtga gcaggggcag acaggtgacg tgcagcgcgg 32940
cgtcgagcag ggccgggtgt acgccgtacc gggatgcgtc gtcctcctgt tctccgggga 33000
gcgtcacctc ggcgtagagg gtgtcgccgt cgcgccaggc cgcgcgcagg ccctggaagg 33060
ccgggccgta gaggtagccc gctgtcgcga gccgctcgta gaagccggtg atgtcgacgg 33120
cttgggctcc cggtggcggc cacgcggacg ggcccgccgc cattgtgctt ccggcgcggg 33180
tgagggttcc ggtggcgtgg cgggtccagg tgtcggttcc ttcggggcgg gcgtggacgg 33240
tcaccgggcg gcgtccggcc tcgtcgggcc ggtcgacggt gacggtgagg tcgacggctc 33300
cggtgaccgg aagggcgagc ggtgtctcga tgaccagttc ctcgaccagg tcgcagcccg 33360
cctcgtcacc ggcgcggatc accagctcca ggaacgcggt acccggcagc agtaccgtgt 33420
cgtggacggc gtggtcggcc agccagggat gcgtggtctg cgacagcttc cctgtcgcca 33480
acaccccgtc gctgcccggc agcgccacgg cggtcgtcag cagcccgtgc ccgataccgt 33540
cgccgccggt cggcttgggc aacagccagt agcgcttgtg gtcgaagggg taggtgggga 33600
ggtcgaggag ccgtaccccg gtgggcggga cgatggtggt ccagtcgacg gccgcgccgt 33660
ggacccaggc ttcggccagg gcggtggtga accggtctcc gccgccgtcg tcggtacgca 33720
gggaggcgac ggtacgttgc tggtcgatgg cgggcagcag caccgggtgc gcactgcact 33780
cgatgaagag ggagccgtcg agttctgtga tggcggtgtc cagggctacc ggttgacgga 33840
ggttgcggta ccagtagccg tcgtcgaccg gctcctccac ccagccgctg tcgaccgtgg 33900
accaccaagg gatcacagga gtacgggtgg ttacgccttc cagcacctcg gccagttcgt 33960
cctcgatggc ctcgacgtgg ggggtgtggg aggcgtagtc gaccgcgatc cgccgaaccc 34020
gtacccccgc agtttcgcac cgggccagaa ccccctccac cgcctgcgca tctcccgcga 34080
tcacggtcga cgacgggccg ttacgggccg cgatccacac cccctccacc gtctcgatgt 34140
cggcagcggg gagggcgacc gatgccatca ccccccgccc cgccagccgg cccgcgatca 34200
cccggctccg caaagccacc acccgcgccc cgtcctccag gctcagcgca cccgccacac 34260
acgccgcagc aatctccccc tgcgaatgcc ccaccaccac atccggcacc acaccatgcg 34320
ccccccacag cgccgccaga ctcaccgcca ccgcccacga caacggctgc accacctcca 34380
cagccccgga atcgtgccgc ccggccagca cctcacccag atcccagccc gtgaacggct 34440
tcaacgccgc cgcacactca cccatccgcc gcgcaaacac ctccgaccac cccatcaact 34500
ccacacccat tcccacccac tgcgacccct gccccgggaa cacgaacacc gtccgcaacc 34560
cctcacccgc cacacccgta accctgctct cccccaacag caccgcccga tgaccgaaca 34620
ccgcacgccc ccgcaccaac ccatccgcca ccacacccac atcacaccca ccccccacca 34680
acccacccac ccgctccacc aacacaccca cacccacacc cgaacgagcc gacaccggca 34740
acggcaccaa accaccggac tcgggctcag cggcagaaac cgaaacctcc ggcaccccct 34800
ccaacaccac atgcgcattc gtcccactca ccccgaaccc cgacaccccc gcccgccgcg 34860
cacgccccga ctccggccac ggcctcgcct ccgtcagcag ctccaccgcc cccgccgacc 34920
agtccacatg cgacgacggc tcaccgacgt gcaacgtcct cggcagcacc ccgtaccgca 34980
tcgccaacac catcttgatc acaccagcca caccagccgc cgcctgcgca tgaccaatat 35040
tcgacttcaa cgaacccaaa tacagcggca cctcacgccc ctgcccatac accgcaataa 35100
ccgcctgcgc ctcaatcgga tcccccaaca ccgtccccgt cccatgcgcc tccaccacat 35160
ccacatccgc cggacccaac cccgcccgct ccaacgcccc acgaatcacc cgctgctgcg 35220
ccggaccatt cggcgccgac aaaccattcg acgcaccgtc ctgattcacc gccgaacccc 35280
gcaccaccgc aagcaccgaa tgaccatgac gctccgcatc cgacaaccgc tccaccacca 35340
gaacaccggc tccctcggcg aatccggtgc cgtcggccgt atcggcgaac gccttgcacc 35400
gcccgtccga ggccaccccg ccctgccggg agaactccac gaagctctgc ggcgacgcca 35460
tcaccgtgac cccgccgacc agcgcaagcg agcattcgcc gctgcgcagt gcctgccctg 35520
cctggtgcag ggcgaccagc gacgacgagc acgccgtatc gaccgtcacc gccgggccct 35580
ggagtccgaa gaagtaggag aggcgtccgg cgagcaccgc gggctgtgtg ctgtacgcgc 35640
cgaacccgcc caggtcggcg cctgctccgt agccgtagta gaagccgccg acgaagacgc 35700
ccgtgtcggt gccgcgcagg gtgtccggca cgatgcccgc gcgttcgagc gcctcccagg 35760
cgatctccag aaggatccgc tgctgcgggt cgagcgcggt ggcctcgcgc gggctgatcc 35820
cgaagaacgc ggcgtcgaag tcgccggctc ccctgagggc gcctgcccgt gaggtggccg 35880
actcggcgtc ggcgtggagc gcggccacgt cccaaccgcg gtcggtgggg aagtccccga 35940
ccgcgtcgcc cccggcctcg acgagctccc acagctcttc cggcgatgtg atgccgccgg 36000
gcagacggca tgccataccg acgacggcga gcggctcgtt cacggcggcg cgcagcgcgg 36060
tgttctccct gcgcagcttc gcgttgtcct tgaccgatat ccgcagcgcg tcgatcagct 36120
cgttctcggc catcgcctca tcccttccgt acatgcgcga tgagcgcgtc ggcgtccatg 36180
tcgtcgatca actcctcgtc gagcaactcg tcgtcgatcg acttgttgtc gggctccgcc 36240
gcctgagggt tctcgggcgt ccgcgccacc ggcggttcac cgccgtcctg ggtcgcgctg 36300
ccatccgggt tcaggagcgt gagcaggtgg cgggtgagtg tcccggccgc cggatagtcg 36360
aagacgaggg tggccggcag tggggtggcg agggcttcgg ccaggcggtc tcgcaggccg 36420
agtgcggtga gggagtcgac cccgaggtcc ttgaaggccg cggtggccgt gaccgcccgg 36480
gcgtcggcgt ggccgagcag tgcggccgcg gtgtcgcgaa ccagcccgag tactgcctgc 36540
tcctgttctt cgggcgacag gtccggcagt cgctccggca gggtgccgcc gcttgcggcg 36600
gcgcgccggg tgggccgccg gaccggccgc cacagcggtg acgggtcacc gggcgggggt 36660
ggggcggtcg ccacgaccac ggcctctccg gtggcgcgtg ccgcgtcgag cagttcggtc 36720
tgccggtcct cggcggccgt gaacgccatg gcgggcagcc cttctgcccg gcgcagttcg 36780
gcgagggctt cccacggccc tgccgcctcc ccgggcggaa cgagcaggac gaacgcgtcc 36840
agcgggagtt cgcgggtgag ccggtgcagt tcccacgccg actcggcggt gcctgccgcg 36900
tggacgaccg cggtcaccgg ggacccgggc agcctgcccg gctcatggcg gatcacctcg 36960
gctccctgcc cggtcagctg ccgggcgagg tcgtccgacc caccggcgag gagcacgacg 37020
ccgccgtacg ggggtggatc ggtgcggggc ggggccggga ccaggcgtgg tgcttcgagg 37080
cgtccaccgg tgagcctgag gtgcggttcg tcgaggcggg cgaaggccgc ggcgcggcgg 37140
ggtgtgatcg tgtcggcggt ctgcaccagc acgatccgtc cgggtggtga ggtgtcgacc 37200
agcgccgcga cggcaccggc agtggttccg gcggccgcgg acacgaccag cgtggcgccg 37260
gccgtcctcg ggtcgtcgag cgcggtgcgt acgtccgcgg gatcggacgc cctgaccacg 37320
aggacatcgg ggcgggtcgt gtcgaacggg tcgcccccgg gcgcggtgcc gtcgcccggg 37380
tccgggtatc tgacggcggt ggtgccgggt gccgcgggcg ccctgacacc ggtccaggta 37440
cgccggtaca ggcgtacgtc tccgcccgga tccggggtgg cggggggccg ggtgacgagt 37500
gacccgatct ccgcgaccgg ccgtcccgtc tcgtcggcga gatggacgcg ggcaccgccg 37560
tcggcggcgg tgaaggtgac ccgcgccttc gtggcgccgc tcgaatggac ccgtacaccg 37620
gagaacgcga acgggacccg gacccccgcg tcctcggagc ccgcgctcag gctgcccgcc 37680
tggagcgcgg tgacgagcag cgccgggtgc agggtgtagc gggaggcgtc cctggcgagg 37740
gcgccgtcga cggccacctc cgcgaagacg gtgtcaccgt gtcgccatgc cgcggacagg 37800
cctcggaacc cggggccgaa cccgtacccc tcgtcgtcga gccttcggta gaactccgcg 37860
gtgtcgagct gctcggcgtg cgcgggcggc caggggccgt cggtcgtggc cggctcggcg 37920
gtggcgatac cggcccggcc cgaggcatga cgggtccacg tcccgtcccc gtctttccgg 37980
gcgtggatgc gcacggcgcg gcgtccgccg tcgtcggctg cggcgacggt cacgcggacc 38040
tgtacggcgc cggtcgcggg cagcgccagg ggggtctcga tgaccagttc gtcgagcagg 38100
tcgcagcccg tctcgtcggc ggcgcgcccg gccagctcca cgaacaccgg tccgggcagc 38160
agcacttcgc ccgcgacgga gtgcccggcg agccacgggt gggtggcgag ggagaaacgg 38220
ccggtgagca gcgtctcgtc ggtgtcgggc agggccacgg acgcggcgag cagcgggtgg 38280
tccacggcgt cgagtccgag gccggtggcg tccgtaccgg atgacggttc gatccagtag 38340
cgctcgtggt ggaaggcgta cgtcggcagg tcgtgtgccg gtcccgggac gggtccggat 38400
gccgtccttg tggtgtcgtg tgccgtcccc ggtgccgcga cgacggtcgg ccagtcgacg 38460
gccacaccgg ccgtgtacgc cttggccagc gagtcgacga cctggtcggc ccctccgccg 38520
cggcgcagcg tgccgacggt tgtgccgttg atcgcgggca gcagtaccgg gtgggcgctg 38580
acctcgacga agacggtgtc acccggctcg cgggcggcgg ccacggcggc ggcgaaacca 38640
acgggattgc gcagattgcg gaaccagtac tcgtcgtcca gcggggagtc gatccaccgc 38700
tcgtcggcgg tggagaacca ggggattcgg ggcgtacggg aggtggtggc cgcggcgatc 38760
cgctggaact cgtcgtacag cgggtcgacg aacggggtgt gggtcgggca gtcgacgacg 38820
aggcgggtca cccagacgcc tcgggcctcg tagcgggcga tcagcgtttc gacggcgtcg 38880
ggccgcccgg acacgatcgt ggtgccggtg ccgttgcggc ccgcgaccca gacgttgtcg 38940
acctgtgcgg cggccgcctc gacgtcggcg gcggggaacg cgatcgaacc catcgcgccg 39000
tgtccggcga gttcgcgctg gagcagggcg gagcggagcg cgacgagccg ggcaccgtcc 39060
tccagtgtga tcgccccggc gacacaggcc gcggcgatct ccccctggga gtggccgatg 39120
acggcgtccg gacgtacccc cgcggcctcc cacacggcgg ccagggacat catgaccgcc 39180
cagcagacgg ggtggacgac gtcgacgcgg cttttcacgg ccgggtcttc gagcatggcg 39240
atcaggtcgc ggcccgtgtg ttcggcgagc gcgtccgcgc actccctcat ccgggccgcg 39300
aacaccggtg actcggccat cagtttcagg cccatgccga gccactggga gccttgtccg 39360
gggaagacga agaccgtacg cggccgggtg agcgccgtgc cggtgacagc gccttcgccg 39420
aggagcacgg cgcggtgcgg gaactcggtg cgggtggaga acagcgcggc ggcgacggta 39480
cgcgggtcgt cgccggggtg ttcggccagg tgtgcgcgga gccgttggat ctggccttcg 39540
acggcctcgg gggtacgggc cgagaccggg agcggggtgc gctccgtgag gaacagcggt 39600
tcgcggggcg ccacggacgg tgaagctgcg gacggtgaat ccggagccgc gggggcttcg 39660
aggatgacgt gggcgttggt gccgctgacg ccgaaggagg agacggcggc ccgccggggc 39720
cggctcgtcc cgggccaggg ccgggcttcg gtgaggagtt cgactcctcc cgccgtccag 39780
tcgacgtgcg acgacggtgt gtcgacgtgc agggtgcggg gcagggtgcc gtggtgcatg 39840
gcgaggacca ttttgatgat gcccgcgacg cccgcggcgg cctgggtgtg gccgatgttg 39900
gacttcaggg agccgaggag gagcggtgtg gtgcggctct gtccgtaggt cgcgaggagc 39960
gcggtcgctt cgatggggtc cccgaggcgg gtgccggtgc cgtgtgcttc gaccgcgtcg 40020
acgtcggaag gttcgagccg cgcgttcgcg agggcttgcc ggatgacgcg ttcctgggag 40080
ggtccgttgg gtgcggagag tccgttggag gcgccgtcct ggttgacggc ggagccgcgt 40140
acgaccgcga gaacacgatg gccgagccgc tcggcatcgg aaagccgctc caccaccagc 40200
acaccggaac cctccgcgaa ggcggtaccg tccgcggcgt ccgcgaaggc cttgcaccgg 40260
ccgtccgagg cgaggccccg ctgctgggag aactcgacga aaccggacgg cgaggccatc 40320
accgtgacac cgccgaccag tgccagagaa cactccccgg tacgcagcga ctgaccggcc 40380
tggtgcagcg cgaccagcga cgacgaacac gccgtgtcga ccgtgaccgc cgggccctcc 40440
agaccgtaga agtacgagag acggcccgac agcacactgg tctgggttcc ggtggcgccg 40500
aatccgccga ggtcggtgcc gaggccgtac ccgtcggaga acgcgccgat gaacacaccg 40560
gtgtcgctgc cgcggagcgt tccggggacg atgcccgcct gttccagcgc ctcccacgac 40620
gtttccagga cgatccgctg ctgcgggtcc atcgcgaggg cctcacgcgg gctgatcccg 40680
aagaacgcgg cgtcgaagtc ggccgccccc gggaggaacc cgccgtgccg gaccgtggac 40740
gtgcccggat gcccggggtc gggatcgtag agcgcgtcca cgtcccagcc gcggtcggcg 40800
gggaacgccg tgatgccctc gccaccggac tccagcagcc gccacagacc gtcgggtgac 40860
gcgaccccgc ccggcagccg gcaggccatg cccacgatcg ccagcggttc gtcgactgcc 40920
atggccgggg tcggcgcgcg ggtgggctcc gccgggcggc cggacagggc ggtggtcagc 40980
ttcgccgcga cggcttgcgg cgtcgggaag tcgaagaccg cggtcgcggg gagccgtaca 41040
cctgtcgcct cggtgagcgc gttgcgcagc cggaccgccg tgagggagtc ggcgccgagt 41100
tccttgaagg tcgcggtcgg ttcgatccgg tcggcgccgt cgtggccgag cacggccgcc 41160
gcgcactccc ggacgacggc gagcgcgacc ttctccgctt cggccgcgga gagtccggcg 41220
atccggtccg cgagcgctcc ggcaccggcc gtacggcgcc gggggaccct gcccgctgcc 41280
ctgaggaggg gcgtatcacc gagccccgcc gggtcggcgg cgacgagcgc cgcgtccggg 41340
gaccgcaggg ccgcgtcgaa gagcgccagt ccgcgttcgg tgctcagtgc cgtgacgccg 41400
gatcggcgca ggcggtcgcc ggccccggcc gtcagtccgc tctccggctc ccacaggccc 41460
caggccaacg acagggcggg cagtccggtg gcccggcgct gtacggcgag ttcgtcgagg 41520
aacgcgttcg ctgccgcgta gttgccctgg ccggggctgc cgagcacccc ggcggccgag 41580
gagtagagca cgaacgccgc gaggtcctgg tccttggtga gttcgtgcag gtgccaggcg 41640
ccgtcggcct tcgggcgcag gacggtgtcg agacgctccg gcgtgagtcc ggtgaggact 41700
ccgtcgtcga tgacggccgc ggtgtgcacc acggcggtca gggggtgtgc ggggtcgatc 41760
cccgccagtg ccgataccag ctcgtcccgg ttcgcgatat cgcaggcgac ggccgtgaca 41820
tgggcgcccg ggacgtcgtt cgccgtgccg ccgcgggaca gcatcagcag ccggcgtact 41880
ccgtagtggt cgacgaggtg ccgggcgatg atgcccgcca gtgttccgga ccctccggtg 41940
atgaggaccg tgccgtccgg gtcgagtgcg ggagcgtcac cggccggggc cgccggggtg 42000
agcctgcgcg gataggtccg gccgtcgcgc agcacggtct gtggttcacc gaggacggcg 42060
gccgccgcca gcagcggggc ggcggtgtcc ggtgcggcgt cgacgagggc gatccggccg 42120
gggtgctccg cctgcgcggt tcgtacgagg cccgcgacgg ccgcggcggc gaggccgggc 42180
ccggtgtgga cggcgagcac cgcctcggcg taccggtcgt cggtgaggaa gcgctgcagc 42240
gcggccagca cctcggcccc gaggcgccgt acctcgtcga gcggggcgcc cccggtcccg 42300
tacgcgggaa ggatcacgac gtccgggacc gtcgggtcgt cgagtccacc ggtcgtcgcg 42360
gtggtggggg gcggttcctg tatctcggcc ggctctgcca gtacgggtcg cagcaggccc 42420
ggaacggctc cttcgacggt cagggggcgg ctgcggacgg cgccgacggt ggcgacgggc 42480
ctcccggtcc cgtccgtgat gtgtacgccg tgggcggtga cggcgacccg taccgcggtg 42540
gctccgccgg tgtggacgcg cacgtcgtcg aaggcgtacg gaagatcggt ccccgccgcg 42600
gcgagggtga gcgcggcgcc gagcagagcc gggtgcagtc cgtagcgccc ggcttcggac 42660
agccggtctt cggcgaggga cacttcggcg tagacggcgc cctcgtcggt ccaggccgcg 42720
tgcggccggg gctgcgcggg gccgcccgtg tgaccggccc tggccagggc gtccgcctgc 42780
tctccgacat ccaacgggcg ggccgtcgcg ggcggccaca ccgacggtgc tgccaaggcc 42840
ggggccgggg ccggggcttc ggcggcgagg attccggtgg cgtgcccggt ccactcgccg 42900
ttgccgtgcc gggcatgcac ggtgaccgtg cggcggccgt cttcccgggg cgccgcgacg 42960
gtgacggaga gcgcggcccc gccggactgc ggaagcacca gcggggtgtc cacggcgaag 43020
gtctccagaa caccgcagcc ggcttcgtcg cccgcggtga ccgccaggtc gacgaggacg 43080
gcggccggga gtaccgcgat gccgtgcacg gagtgcgcca gtggatcggc ggcgtcgacg 43140
cggccggtga ggaccagttc accgctgccg ggaatactga ccgccgcggt cagcaccggg 43200
tggtcgacgg gcagctgacc cgcgggggcc gtatcgccgc tgccgcggga cgccgaccag 43260
tagcggtccc gcgcgaacgg gtacgtcggc aggtccggcg gcgaggccgg cgcggggccg 43320
atgaccttcg gccagtcgac cgtggcacca ctggtgtgga ggcgggcgag cgcggtcatc 43380
gcggaccggg gctcgtcgtc gccgtgcagc atcgggatgc cgtcgacgag gcgggacaga 43440
ttgcggtccg ggccgacctc caggagcagc gccccgtcgt acgcggcgat ctgctctccg 43500
aaccggacgg tgtcgcggac ctgccgcacc cagtactccg gtgtcgcgca ctcggcgccc 43560
gcggccatcg gaatcttcgg ctcgtggtac gtcagcccct ccgcgacctc ccggaacgcg 43620
tcgagcatcg gttccatccg ggccgaatgg aaggcgtggc tggtccgcag gcgggtgaag 43680
cggccgagtc gggccgcggt gtcgagcacc gtggcctcgt caccggagag gacgatcgac 43740
gaggggccgt tgaccgcggc gatctccacg ccgtcgcgca gcagcggctg cgcctcctgc 43800
tcggacgcga cgacggcggc catcgcgccg ccgtgcggca gggcctgcat cagccgggcg 43860
cgcgccgcga ccagggtgca cgcgtcgtcg agggaccaga caccggcgac gtacgccgcg 43920
gccagctcgc cgatggagtg gcccacgagg acgtccgggc gtacgcccca ggtgtcgagc 43980
tgggcgctga gcgcgacttg gagggcgaag accgaaggct gggcgtatcc ggtgtcgtgg 44040
aggtcgagtc cggtgggcac ccggagggcg tcgaggacgt cacggcgggt gcgggcgaac 44100
acgtcgtacg cggcggccag ttcgtcgccc atgccggggc gttgcgagcc ctgcccggag 44160
tagagccaca ccaggcggcg gtccggttcg gcggtgccgg tgatcaggtc cgtgccgatg 44220
agggccgccc ggtgccggaa ggccgtacgg gcgagcaggg ccgaggccac ggcgtgttcg 44280
tcgcagcttc cggagtcgcg gaaggcccgg atgcgggtgg tgtgttcatg gagggcgcgg 44340
ggggtgcggg cggagatcag caggggtgcg gggtgggcgc cgggcggggt ctcggcttcc 44400
ggctgggggc ggctttcgag gatgacgtgg gcgttggtgc cgctgacgcc gaaggaggag 44460
acggcggccc gccggggccg gccggtatcg ggccagggcc tgggttcggt gaggagttcg 44520
atgctgcctg ccgaccagtc gacgtgggtg gtgggccggt cgacgtggag cgtcgggggc 44580
agggtgccgt ggcgcatcgc caggaccatt ttgatgatgc ccgcgacgcc cgcggcggcc 44640
tgggtgtggc cgatgttgga cttcagggag ccgaggagga gcggcgccgt acggtcctgt 44700
ccgtacgtct ccagaagcgc cctggcttcg atggggtcac cgaggcgggt gccggtgccg 44760
tgcgcttcca cggcgtcgac gtcggaaggt tcgagccgcg cattggcgag ggcttgccgg 44820
atgacacgtt cctgggaggg tccgttgggt gcggagagtc cgttggaggc gccgtcctgg 44880
ttgacggcgg agccgcgtac gaccgcgagg acgcggtggc cgaggcgttc ggcatcggaa 44940
agccgctcca ccaccagcac accggaaccc tccgcgaagg cggtaccgtc cgcggcgtcc 45000
gcgaaggcct tgcaccggcc gtccgaggcg agaccgcgct gctgggagaa gtcgacgaaa 45060
ccggacggcg aggccatcac cgtgacgccg ccgaccagtg ccagggagca ttccccggta 45120
cgcagcgact gaccggcctg atgcagcgcg accagcgacg acgagcacgc cgtgtcgacc 45180
gtgaccgccg ggccctccag tccgtagaag taggagaggc ggcccgacag cacactggtc 45240
tgggtgctgg tggcgccgaa tccgccgcga tcggagccgg agccgtaccc gtagaagtag 45300
ccgccgatga acacgccggt gtcgctgccg cgcagggtgt gcgcgtcgat gcccgcgtgt 45360
tcgagcgcct cccacgacgt ttccaggacg atccgctgct gcgggtccat cgcgagggcc 45420
tcgcgcgggc tgatcccgaa gaacgcggcg tcgaagtggg ccgcccccgg gaggaatccg 45480
ccgtgccgga cggtggacgt gcccggacgg tcggggtcgg ggtcgtagag cgcttccagg 45540
tcccagccgc ggtcggcggg gaatgccgtg atgccgtcgc cgcccgactc cagcagccgc 45600
cacagatcgt cgggggacat gaccccgccc ggcaggcggc acgccatgcc cacgatcgcc 45660
agtggttcgt cgtggcggcg ggccggggtc ggtgtacgtc gccgggtggc cgcccgggta 45720
ccggccagtt cgtcgaggtg ggcggcgagt gcctgcggtg tggggtggtc gaagacgagt 45780
gtggcgggca gggtcagacc cgtcgcgtcg gtcagccggt tgcgcagctc gacgccggtc 45840
agtgagtcga agcccacgtc tttgaacgcg cgcaggggtt cgacggcgtg cacgtcgcga 45900
tggccgagga ccgcggcggc actcgtcctg acgagttcga gcatgtcgcg cgagccggcc 45960
ggtgcgggcg tgcgccgcgc ggccggtacc aggtcgcgga ggatcggtgg gacgtgatcc 46020
gccgcggcga cggcggcgag gtcgaggcgg acggggacga gtgcggcgcg gtcgctgtgc 46080
agggccgcgt cgaacagggc gagtccttgc gcggccgtca tcgggatcat gccgccgcgg 46140
gcgatgcggc cgaggtcggt ggaggtcagc cgtccgccca tgccgtccgc ctcgtcccac 46200
agcccccacg cgagggagac ggcgggcagt ccccggtcgc gccggtggcg ggcgagcgcg 46260
tcgaggaacg cgttgccggt cgcgtagttc gcctgccccg ccccgccgaa cgtcgcggag 46320
atcgacgagt acaggacgaa cgccgcgagt tcggtgtcgc gcgtcagttc gtgcaggtgc 46380
caggcgacgt cggccttcac ccgcagtacg tcgtcccact gttggggccg catggtcgcc 46440
acgaccgcgt cgtcgacgat cccggccatg tgcacgacgg cgcggagccg tccggagatg 46500
ccgtcgacga gggcggccag cgcgtcccgg tcggtgacgt ccacggccgc gtaccgcacc 46560
cggtcgtcct caggcgctcc gccgggccgg ccgccgcggg acgccacgac gatctccgct 46620
gcctcgtgga cggtgagcag atggtccacg agaaggcggc cgaggccgcc ggtgccgccg 46680
gtgacgagga cggttccccc ggtcagcgcg gaggctcccg cggccgcggc gacacggcgc 46740
agacgagcgg cgcggaccgt ccctccggcg acccggaccc ggggctcgtc accggcggcg 46800
agcccggccg cgacggtggc gggcgtgatc tcgtccgctt cgatcaggcc gacgcggccg 46860
gggttctccg tcccggcggt acggaccaga ccgccgagcg cttcctgcgc gggatcgccg 46920
gtgcgggtga ccacgacgag gcgggaaccg gcccggcggg ggtccgcgag ccacgtctgc 46980
accgtcgcga gcagatcgcg gcccagctcc cgggcccgga cgccgggcga tccgccgcgg 47040
tcgccggggt cgccggggtc gccggggtcg ccggggtcgc cggggtcgcc gggctccaag 47100
ggaaggacca cgaccggggg agtatcccct tcggggacat cggcgtgata cgtccagccg 47160
gggacgggcg cggccggcac gggaacccag acgacctcga acagcgcgtc gttgccgggc 47220
tccgcgcccc gtacggtcag accgtccgct tcgaggaccg gggcgccgtg ctcgtccatg 47280
gcgaggaccc ggatcgtgtc ggcgccgacg cgttcgagga gcacccgcag cgcggtggcg 47340
gcgcgcgtgt acatccgtac gccggtccag gagaacgcga gcctgcgccg ctccggatcg 47400
tcgaagagca tgccgagggc gtgcagtgcc gcgtcgagca ggacggggtg cagtccgtac 47460
cgggcgtcgg tgagctgttc accgaggcgg accgacgcgt aggcgcgtcc ccggccggcc 47520
cacagcgccg tcacggcgcg gaaagcgggc ccgtagctga gcggcagcgt gtcgtagaag 47580
cctgccgggt cgaccgggtc ggcatcgggg ggaggccact cgggcgtcgc cggttcgcgg 47640
gtctcggcgc tcagcgctcc ggtggccacc agggtccacg gccccgtacc ggtacggctg 47700
tgcaggcgta cgggccgctg cccggacacc tcggagccga ccgtgaactg gacctctgtg 47760
gccgcgtcgg cgtcgaccac cagcggtacg acgatcgtca gctccgcgat cgccggtgta 47820
ccgagccggg tgcccgcctc ggcaaggagt tccacgagcg ccgagccggg cacgatgatc 47880
cgcccgtcga cctcgtggtc ggtgagccag ggctgtcggc gtaccgagaa cagcgcggtg 47940
gcgagcgccc cttcgccgtc ggcacggtcg accagcgagg ccagcagcgg atgcccggag 48000
ccgccggccg gttccgcgtc gatccagtag cggtcgcgcc ggaacgggta cgtgggcagc 48060
ggcacactcc gggacacccc gaacgaccag gtgacgggta cgccccggac ccagagcgcg 48120
gcgagcgact tgccgaagcg gcgcggcccg ccctcgccgc gccgcagcgt gccgaccacc 48180
accgtgttcg gctgcccggc gagcgtgtcc tccagcgcgg gggtgaggac cgggtgcggg 48240
ctggtctcga cgaatacgcg gtagccgagt tcgtcgaggc ggctcgtcgc gacgccgaag 48300
cggacggggc ggcgcacgtt gtcgtaccag taggcggcgt cggcgggccg gtcgagccac 48360
tccccgtcca cggtggagaa gaacgggatc tccggtgctc gcggggtgag gtcggccagg 48420
gcgtcgagca gggcttgacg gaccgtctcg acgtgcgcgg tgtgcgacgc gtagtcgacg 48480
gcgatccggc gggcacgggg tgcggcggcg aggaactcct ctacggcatc ggccgctccg 48540
gcgacgacga tcgacgcggg cccgttgacc gcggcgacct ccaggcgccc cgtccacgcg 48600
gcggcgtcga agtccgcggg cgccaccgcg accatgcctc ctcgcccggc gagttcggcg 48660
gcgacgagcc ggctgcgcag cgcgacgacc ttcgcggcgt cgtcgagggt gagcgccccg 48720
gcgacgcagg ccgcggcgac ctccccctgg gaatgcccga ccaccgcggc cggggcgacc 48780
ccgtgcacgc tccacagctc cgcgagggcc accatcaggg cgaacgacgc gggctgcacg 48840
acatcgaccc ggtccagagc gggcgcgccg ggccgttggg tgatgacgtc gaggaggtcc 48900
cagccggtgt gcggggcgag ggccgcggcg cactcaccga gccgccgcgc gaagacgggt 48960
tcggccgcga gcagttcggc gcccataccg gcccactggg agccctggcc cgggaacacg 49020
aacacggcgc gcgggtcggt gatgtcggcc gttccccgca ccacgtccgg cacttcctcg 49080
ccgcgggcga acgcctccgc gtcccgggcc gggacaaccg cccggtggcg catggccgtg 49140
cgggtggtgg cgagcgaatg cccgatcgcg gccgcccttg ccgtgagggc ggccatacgg 49200
gccgcgacgt cccgcacccc gtccgaggtg cgggccgaaa ccggccacag cacgtcctgc 49260
gtctcggcct cggggagcgg tacgggagcg gcggggggca cgggagcggt ggaggggccg 49320
ggggcggcgg ggagaccgag agtcgcggag ggaccgagac tcgcggagga accgggagcg 49380
gcggaggggc cggactccag caccacatgg gcgttggcac cgctgatgcc gaacgacgag 49440
acgcccgcgc gccgggcgcg gccggtgtcc ggccacggct cgttgcggcg cagcagccgg 49500
acgttgccgt cccagtcgac gtgccgggac ggttcgtcca cgtacagcgt gcgcggcagg 49560
acgccgtgcc gcatcgccat caccatcttg atgacacccg cgataccggc cgccgcctgg 49620
gtgtggccga tgttcgactt gagcgagccg atgagcagcg ggcgctcgcg gccggccccg 49680
tacgccgcct ccagtgcctg ggcctcgata gggtcgccga gacgggtacc ggtgccgtgt 49740
gcctccacgg cgtcgacctc gcccggtgcg aggcccgcgt cggcgagcgc acgttcgatg 49800
acgcgctgct gcgcgggacc gttcggagcg gagaggccgt tcgaagcgcc gtcggagttg 49860
accgcggagc cgcgcaccac ggcgagcacg ggatggccga ggcgggtggc gtcggagagc 49920
cgctcgacga tcaggacacc ggcgccttcc gagaagctgg tgccgtcggc ggtgtccgcg 49980
aacgccttgg cccggccgtc gggggcgagc ccgcgctgac gggagaactc gacgaatccc 50040
gtcgtcgtcg ccatgacggt gaccccgccg accagcgcga gcgaacactc ccccgagcgc 50100
agcgaccgcg cggcctggtg cagggcgacc agcgacgacg agcaggccgt gtcgacggtg 50160
acggaggggc cctcgaaccc gaagtagtag gagagccgtc cggagagcac gctcgtcggc 50220
gtgccggtcg ccccgaagcc gcccaggtcg acaccggcac cgtacccctg gccgaacgcg 50280
cccatgaaca ccccggcgtc gctgccgcgg acgctcgcgg gcaggatgcc cgcccgttcg 50340
aacgcctccc acgacacttc gaggatcagc cgctgctgcg ggtccatcgc cagcgcctcg 50400
cgcgggctga tgccgaagaa ctcggcatcg aagtcggccg ccccggcgag gaacccgccg 50460
tggcgcacgg agaccttgcc gatcgcgtcg gggtccgggt cgtagagcgc cgcgaggtcc 50520
cagccgcggt cggtggggaa atcggtgatc ccgtcgccac cggattcgac gaggttccac 50580
aggtcttccg gggtatccgc accgccgggc atccggcagg ccatggccac gatcgccagc 50640
ggttcgtccc ccgccaccgc cttcgggggt acgggcgccg gggccgcggt ctccgcaccg 50700
cccggcggcg ctccggcact gcgcagggcc gcggcgagct gcgtggcgag cgcgtccgga 50760
gtcggatggt cgaagacggc cgtcgcggag agcctgacgc cggtcgtctc ggcgagcctg 50820
ttgcgcagcc ggataccgct gagcgagtcg atgccgagat ccttgaacgc ggtcgcgggc 50880
ccgataccgg aggcgtccgg gtggcccagc acggcggcgg tggccgaaca cacgacggcc 50940
agcagatcac ggccgcggtc ctcgcccgta cggacggtgg ggcgctccac gcgccggcgg 51000
gcgggctcgg attcgggtac ggatacggat tcgggtgcgg cggggatcgc cgcgatcacg 51060
aacggctcgt ccgtggcgag gctcaggtcg aggaagtgcc tgccctccgc ctcggtgagc 51120
ggccggaacc cgtcgcgcac ccgctgtcgg tcggtgtggg tgagttgggt ggtgaggttg 51180
gtggtggttt gccacatgcc ccaggcgatg gtggtggcgg gttgtccttg ggtgtggcgg 51240
tgggtggcga gggcgtcgag gaaggcgttg gcggcggcgt agttggcttg tccggggctg 51300
ccgagggtgg cggctgctga ggagtagagg atgaagtggg tgagggggtg gtgttgggtt 51360
tgttggtgga ggtgccaggc ggtgtgggct ttggtggtga gggtggtggt gaggtggtgg 51420
ggggtgaggt tgtggagggt ggcgtcgttg agggtggctg cggtgtggta gatggcggtg 51480
aggggttggg gtatgtggtg gagggcttgg gtgagttggt gggggtcggt gaggtcgcag 51540
gggatgtggg tgccgggggt ggtggggggt ggtggtgttc gggagaggag gtaggtgtgg 51600
gggtggttga ggtggcgggc gaggattccg gcgagggtgc cggagccgcc ggtgatgagg 51660
atggcgtggt gggggttgag gggtggtgtg ggggtggggg tgtggtggag gggggtgagg 51720
tggggtgtgt ggagggtgtg gtgggtgagg cggaggtggg gttggttgag ggtggtgatc 51780
tggtggaggg ggaggggtgt gtgggggtgg gtggtttcga tgatgtggat gcggtttggg 51840
tgttcgttct gggcggtttt ggtgagtccg gtggctgcgg cgcctgcggg gtcggtggtg 51900
gtgtggacga tgagggtgtg gtgggtggtg gtgaggtggt gttggagggc ggtgagggtg 51960
cgggtggtgc gggcttgggt gagggcgggc atatcggtga ggtcggtgag gtcgtccggc 52020
tcgtcggggt gtgcggcggt gatgagggtg tagccgtcgg ggagggtccc gtcgtagacg 52080
gcttccgcca ccggcaccca ctccaacccg aggagcttcg gtcccgacgg cgtgccggta 52140
cccggtcgta gtaccagcgc gtctacggtg acgacgggac gaccgtccgg atcggccatc 52200
tgcacggtga cgccccccgg gccccggatg agagcgacgc gcaccgcggt ggccccaccg 52260
gcgtgcaggc gcacacccgt ccaggagaac ggaagctcca atgcgtcgcc cgcgtcgagg 52320
cgtccggcgt gcagggccgc gtccaggagc gccgggtgaa ccccgaagcg gtccacctct 52380
tcggcgctgt ccagagcggc ttcggcgtag atcgtgtcgc ccgccgtcca tgcagcgcgc 52440
agcccctgga acgccggacc gtaggtgtag cccgctgccg ccagttgctc gtagaaccgg 52500
tccaggcttg ccggttgcgc tccggccggg ggccactgcg ccaaggtgta cgggtccggg 52560
gcatcggtgg tccgcttggt gccggtggtg agggttccgg tggcgtggcg ggtccaggtg 52620
ccggttccct ggaggcgggc gtggacggtc acggggcggc gtccggcctc gtcgggccgg 52680
tcgacggtga cggtgaggtc gacggcaccg gtgaccggaa gggcgagcgg tgtttcgatg 52740
accagctcgt cgatggtgtc gcagccggtc tcgtcaccgg cgcggatcac cagctccagg 52800
aacgcggtac ccgggagaag taccgtgtcg cgaacggcgt ggtcggccag ccaggggtgc 52860
gcggcgagtg acaccctgcc cttcagcaga acgccgtcgc tgcccggcag ggccaccacg 52920
ctcgacagaa acggatgccc gatgccctcg ctgccgcctg ccggggcggg aggcagccag 52980
tagcgcttgt ggtcgaaggg gtaggtgggg aggtcgagga gtcgttccgg ggtgggcggg 53040
acgatggtgg tccagtcgac ggccgcgccg tggacccagg cctccgccag ggcggtggtg 53100
aaccggtctc cgccgccgtc gtcggtgcgg agtgacgcga cggtacgttg ctggtcgatg 53160
gcgggcagca gcaccggatg ggcgctgcac tcgacgaaga gggagccgtc gagttctgtg 53220
atggcggtgt ccagggctac cggttgacgg aggttgcggt accagtagcc gtcgtcgacc 53280
ggctcctcca cccagccgct gtcgaccgtg gaccaccaag ggatcacagg agtacgggtg 53340
gttacgcctt ccagcacctc ggccagctcg tcctcgatgg cctcgacgtg gggggtgtgg 53400
gaggcgtagt cgaccgcgat ccgccgaacc cgtactcctg tgctctcgta ccgggccaga 53460
accccctcca ccgcctgcgc atctcccgcg atcacggtcg acgacggtcc gttacgggcc 53520
gcgatccaca ccccctccac cgtctcgatg tcggcggcgg ggagtgcgac cgatgccatc 53580
accccccgcc ccgccagccg ggcaccgatc acccggctgc gcaaagccac cacccgcgcc 53640
ccgtcctcca aactcagcgc acccgccaca cacgccgcag caatctcccc ctgcgaatgc 53700
cccaccacca catccggcac cacaccatgc gccccccaca gcgccgccag actcaccgcc 53760
accgcccacg acaacggctg caccacctcc acccgcccca gcaactccgc cgaccccaac 53820
gcctcctccc acgaccagtc cacatgaggt gccaacgccg ccgcacactc acccatccgc 53880
gccgcaaaga caggtgacac ttcagcaagt tcgcggccca ttcccaccca ctgcgacccc 53940
tgccccggga acacgaacac cgtccgcaac ccctcacccg ccacacccat aaccctgctc 54000
tcccccaaca gcaccgcccg atgaccgaac accgcacgcc cccgcaccaa cccatccgcc 54060
accacaccca catcacaccc accccccacc aacccaccca cccgctccac caacacaccc 54120
acacccacac ccgaacgagc cgacaccggc aatggcaaca aaccaccgga cgactctgtg 54180
ggagagaccg aaacctccgg caccccctcc aacaccacat gcgcattcgt cccactcacc 54240
ccgaaccccg acacccccgc ccgccgcgca cgccccaact ccggccacgg cctcgcctcc 54300
gacaacacct ccaccgcccc cgccgaccag tccacatgcg acgaccgctc accgacgtgc 54360
aaggtcctcg gcagcacccc gtaccgcatc gccatcacca tcttgatcac accggccaca 54420
ccagccgccg cctgcgcatg accaatattc gacttcaacg aacctaaata cagcggcacc 54480
tcacgcccct gcccatacac cgcaataacc gcctgcgcct caatcggatc ccccaacacc 54540
gtccccgtcc catgcgcctc gacggcctgc acatcggacc cgctcaaccc ggcgctggcg 54600
agtgcctgcc ggatgacgcg ctgctgtgct acaccgttgg gcgcggagag gccgttggac 54660
gcaccgtcct ggttcaccgc cgtaccgcga atcaccgcaa gcaccgtgtg accgttgcgc 54720
tccgcgtccg acagccgctc caccaccaga acaccgacgc cttcggagaa ccccgttccg 54780
tcggccgtgt cggcgaacgc cttgcaccgg ccgtccggag cgagcccgcg ctgacgggag 54840
aactccacga agctctgcgg ggtcgccatc acggtgaccc cgccggtcag ggcgagggag 54900
cactcgccgc tgcgcagcgc ctgtaccgct tggtgcaggg cgaccagcga cgacgagcac 54960
gccgtatcga ccgtgaccgc cgggccctgg aacccgtaga agtacgagag acgtccggac 55020
agaacgctcg tctggattgc cgtgacaccg agtccgccca ggtcgcggcc tgcgccgtac 55080
ccctggtgga aggcgcccat gaacacgccg gtgtcgctgt ccctgagcgt gtccggcacg 55140
atgcccgcgt gttcgaacgc ctcccatgac gtctccagga ccaggcgctg ctgcgggtcc 55200
atggccaggg cctcgttcgg gctgatcccg aagaacgcgg tgtcgaaccc ggtcgccccg 55260
gtgaggaagc cgccgtggcg ggtcgtcgac cgtccggccg cgtccgggtc ggggtcgtac 55320
agcgactcga cttcccagcc gcggtcggcg gggaactcgg tgatggcgtc gcccccggat 55380
tcgacgagcc gccatagttc ctccggcgat gcgacgccgc ccggcagtcg gcaggccatg 55440
ccgacgatcg cgatgggttc accggggccg acggtccggg ccggggcggg cgccgccgtt 55500
gtggccccgg cgaggtgcgc ggcgaacgca cgcggagtgg ggtggtcgaa cgccgtggac 55560
gcgggaacgc gcaggcctgt ccgggcggcg acgatgttcg cgaattcgac ggtggtgagg 55620
gagtcgaggc cgttctcgcg gaacgtccgg tccggcgcac agtgttcggc gttcgacagg 55680
ccgaggaccg tggcgacggt gtcgcgtacc aggtcgagca gtatgtcctg ccggtcggcg 55740
gcggccgccg cgaggcggtt cgcccatgcc gggtccacgg ctccgggccc atccgggtcc 55800
gccgggccgg cccgtcccgc gagcctgctg agaatcggtg gcgtcgcgcc tgccatcgcc 55860
tcggcccgcg caccggcgga accgacgcgg gtgacgacgt acgagccgcc gcccgcgacg 55920
gccctttcga tcagctccgc cgtgagtgct gcctcttcga ttcccggcag accgtggagc 55980
gtgacggccg ggagcccttc cgaggctcgc gaccgggcgt acgcgtcggc gccggccgga 56040
tcgccgagca cgatatgcac gagcgcactc gtgtccacgg catccgccgt cgccagggca 56100
tccgcgtcgc cggtgaacac gggacccgag tccacttcgc ggcgcagcag accggcgacg 56160
gcgtcggcgc cttccccggt gaccaggacc ggcgtgtccg gcccgagcgg ctgcgggacg 56220
gtgagaacca tcttgccggt gtgccgggcc cggctcatcc aggtgaacgc atcccgcgca 56280
cggcggatgt cccacgcgcg gagcggcagt ggggacagct cgccgcggtc gaacagttcc 56340
aggagcagtt ccaggatctc gcgcagccgt gcgggggcga tgtcggacag gtcgaagggc 56400
tcctgtgcgt cgtgccggat gtcggtcttg cccatctcga tgaaccggcc gtccggtgcg 56460
agcaacgcga ccgaggcgtc gaggagttcg ccggtgaggg agttcagcac gacgtccatc 56520
ggggggaagg cgtccgcgaa ggcggtggta cgggagtccg ccacatggtc ggcgtcgaag 56580
ccgtcggcgt acagcaggtg ctgcttggcc gggctcgcgg tggcgtagac ctcggcgccg 56640
aggtggcggg cgatccgggt ggcggccatg ccgacgccgc ccgtcgcggc gtggatcagt 56700
accttgcggc cgggccgcag gccacccgcg tcgacgagtc cgtaccaggc ggtcgcgaac 56760
acgacgggca cggaagcggc gaccgggaac gaccatccct gcggaaccgg tgcgatcagc 56820
ctccggtcgg cgacgacact gcgccggaac gcgtcctgca ccaggccgaa cacccggtcc 56880
ccgggcgtca ggtcgtcgac cccgggcccg acctcggtca cgattccggc ggcttccccg 56940
cccatctcgc cgtcgcccgg gtaggtgccg agtgcgatca gcacatcgcg gaagttcagc 57000
cccgcggcgc ggacctcgat acggacctca cccgtggcca gggggtgcgg cggggcgtcg 57060
gacggggcga ctgcgaggtc gcggagggtt ccggaggcgg gcggtcgcag tgcccacggg 57120
cccggcggca ggggggtggt gaccgcgtgg accagccggg gtacataggc cgtgccgttc 57180
cgcagggcga ccaggggctc gccgagagag gccgcggcgg caatgcttcc ggccccggcg 57240
gcaccggcgt cggctgcttc tccgtccgtc gtctcgccgt ccgtcgtctc gccgcccgtc 57300
gtctctccgc ccgttgtcct tccgcccgtt gtctctcggc ctgttgtctc tccgcccgtt 57360
ggctcgccgt ccgtatcgac cagcacgaac gatccggggt cggcagcctg gtccttgagc 57420
gcctcgtccc agagcgcggc ctggtccgcg tccggcactt cggccgggtc gatgcccacg 57480
gcacggcggg tgatgacggt cggcaccggc gtgacggtgg tgggcagctc gcgccgttcc 57540
cacaccagtt cgcacagggc ggtctcgccg cttccggtgg cgacgaggcg tgtcgtacga 57600
ccggccagct ctccccggcg taccttcccc gatgcggtgc gcgggatctc cgtggtctgc 57660
aggatctcgt cgggcacctt gaagtaggcg agctggcggc ggcactccgc gaggatcgcg 57720
tcggtgggga cggtgggtcc ctccgggacg acgtagagca cgggtatctc accgaggacg 57780
gggtgggggc ggcccgccgc cgcggcgtcc cggacgcccg gcactgcctg ggcgactgat 57840
tcgatctccc ccgggtggat gttctccccg ccccggatga cgagttcctt gacccgcccg 57900
gtgatcgtca catgtccggt ctccgcctgg cgtgccaggt ctccggtgcg gtaccaaccg 57960
tccacgagca cctcggcggt cgcctcgggc tgctcgtggt agccgagcat gaggctcggt 58020
ccgctcgccc acagctcgcc ctcgtcgccg cgcggcacgt cggcgccgga caccgggtcg 58080
acgaaccgca gcgacaggcc ggggacgggc agtccgcacg agccgggaac cctcgggccg 58140
gtcagggtgt tggccgtgag tgagccggtc gtctcggtgc agccgtaggt atcgagcagc 58200
ggtacgccga aggccgcttc gaagtccgcc gtgagcgagg cgggtgcggt ggatcccgcg 58260
accagcgcgg cgcgcagcgc gcctgcctcc ggttcgccgg acacggcgcc gagaaggtag 58320
cggtacatcg tcggtacgcc gacgagcacg gtgctcgggt gttcggccag ggcgtcgagg 58380
acgtcgcgcg cgacgaagcc gccgaggatc cgggcggacg cgccgacggt gaggaccgcg 58440
agcaggcaga gatggtggcc gaggctgtgg aagagcggtg cgggccagag cagttcgtcg 58500
gtctcggtga gttcccagga cggtacgtcg cagtacagcg cggaccacag gccgcttcgc 58560
tgggcggaga cgactccctt cgggcgtccg gtcgttccgg acgtgtagag catccaggcg 58620
ggttcgtcca gggcgaggtc gtcgcggggc gggtacgccg gttcggttcc ggcgaggtcc 58680
tcgtacgcgg tgcagcccgg atcccgccgt cccgcgagta cgaccgtggc atcggtgccg 58740
acccggcgca cctggtcgag gtggaggtcg tcggtgacca ggacggtcgc gcccgagtcg 58800
gtgaggaagt gggcgatctc cgcatcgccg gcgtccgggt tgagcggcac ggcgacggcg 58860
gcggcacgcg cggcggcgat ataggtctcg atggtctcga cccggtttcc gagcagcagc 58920
gcgatacggt cgccacggcc cacccctgcc gcggcgaggt gaccggcgat ccggccggtc 58980
ctgagccgga gctgcgcgta cgtcacggcg cgtcgggaat ccacgtaggc gatccggtca 59040
ccctgccgtt cggcgttcac gcgcagcaat tcgtgcacag gccgaagtga ttccccacgc 59100
gccatgaaaa cgcctttctc tcggctgacc gtacggcagc acgaagccgg cagtgagtgt 59160
cggcgacgtt agcagcgaac ccctggtgat ccccccctga ccatcccccc tgcccccggc 59220
cgaattctcc cgccgcgcat ttagggggtt gcccgaatac cgtcgcgcgt acttgtctgc 59280
atcgtgaccg acaacggaac ggcagggagg gatgaggctt tgtctgtgcc tgtcgcggca 59340
ccgtactgcc gcttcgagaa gctcgtgccg tcggacctcg aaggggacga gaccgtgctc 59400
ggcgtcatcg agcacggcac cggtcatgcc gaggtgtcgc tcacggacgg tgtcccgcgt 59460
gccgcggtgc acaccacgac cttcgaggag gaggcgttcg ccgaggtgtg gcgcgcgcag 59520
ccgcccgtcg agtccggccg ggacggaggc atcgcatggg cccgcaccga cgagtacctg 59580
ttcggtgtcg gccgcgtccc cgagagccgg gggtacgccg atgccgtcgc ggcgctctac 59640
acgcgggtct tcgggctgac ccggtccctg ggacatccgc tgctcgcccg gacgtggaac 59700
tacatcagtg ggatcaacgc ggcgaacgcg gacgggctgg aggtgtaccg ggacttctgc 59760
gtgggccgtg cgcaggcgct ggacgcgggc gggatcgacc cggccggcct gcccgcggcc 59820
accggcatcg gcacgcacgg gggtggtatc acctgcgtgt tcctcgccgc ccgcggcgga 59880
acccggatca acatcgagaa ccctgccgtc ctcacggcac accactaccc cacggcgtac 59940
ggcccgcgcc ccccggtctt cgcacgggcc acctggctgg gcccgccggg cgacggccgg 60000
ctgttcgtgt ccgcgacggc cggaatcctc gggcacgaga ccacgcacca cggtgatgtg 60060
accggtcagt gcgaggtcgc cctggacaac atcgcccggg tcgtggccgc cgagaacctg 60120
caccggcacg gtgtccggcg gggttacgcc ctcaccgacg tcgatcacct caaggtctac 60180
gtccggcgcc gcgcggacct ccccgcggtc cgccgggtct gcgccgcccg cttggcgagc 60240
accgcgaccg tcgcgtttct gcacaccgac atcgcccgtg gcgacctgct cgtggagatc 60300
gaaggagtgg tgtcgtgaca ccggacggca agaggccggg gacgctccgt ctcggcggtt 60360
ccacaaagaa tcggggaagt cagggaaacg gggaaacccg ggaatcccgg gaaaatcagg 60420
gaagccggaa agaccaggga aaccggggaa accggcatcg ggaaatcggt accgccaacc 60480
gctccgagcc actcctcacc tcgttttcgc agcggcgtat ctggtttctg caggaactgg 60540
atccggacag caatgcctac aatcttccgc tggtgctgcg gctgagcggt ccgctcgacg 60600
cggcgctcct ggagcgggcc ctcgcgctcg tcgtggcgcg gcacgaggcg ctgcggaccg 60660
tgttcgacgc cgcggacggc gaacccgtcc agcgggtgct gccgccgtcg ccccggatcc 60720
tgcgccggtc ccgggcagcc gacgaccggg acgcggcccg gctcgtacgc gacgagatcg 60780
ccgcgccgtt cgatctctcc accgggccgc tgatcagggc cctgctgatc cgggtggacg 60840
acggccggca cgtgctggcg gtggtcgtgc accacatcgc ctgtgacggc tggtcgttcg 60900
ggattctgca gctcgaactc gcagcccact actcggctct ccgggacacg tcccggcccg 60960
ccgtcctgcc gccgctgtcc ctgcagtacg cagacttcgc cgcctgggaa cgatcggagc 61020
tcaccggcgc cgggctcgaa gagcgcctgg cccactggcg ccaccggctc caggacgccc 61080
cgccggtgct ccgtctgccg tccgaccggc cccgtcctgc cgtcgccgcc ccggacgcgg 61140
gcatggtcga gtggcggccg cccgacgcgc tgacctccgc ggtgctccgg ctggggcacg 61200
acgccggtac gacggtgttc atgacgctgc tctcggcgtt ccagatcgtg ctcgcccggc 61260
atgcgggcac gctggacgtg gtggtgggca cgcccgtcgc caaccgcacc cgggcggcgc 61320
tcgaaggcct catcggcatg ttcgtcaaca cgctcgcgct gcgcggtgac ctctccggcg 61380
atcccacgtt ccgggagctc ctcggccgct gccgggccat ggccacggac gcgttcgccc 61440
acgccgacct tccgttcgag aacctcatcg aggtcgtcgc accggatcgc gatctgtcgg 61500
tcaatccggt cgtccaggta ctgctgcagg tcctcagacg cgatacgacg acggccgcgc 61560
tgcccggtgt gaccgccgag cccttctccg ccgggcgctg gttcacccgc ttcgatctgg 61620
aattccatgt ctacgaggag gccgggggga ccctcgccgg agagctgctg tacagccgtg 61680
cgctgttcga cgaaccccgg atcacggggt tgctcgacga gttcacggcc gtgctgcggg 61740
ccgtcacggc cgacccggac gtacggctgt ccggtctgcc tgcgggcgac gccgggacgg 61800
cgccggctcc ggtggtcccc tcgaacgaca cggcgcgggc gctgcccgtc gagacactgc 61860
cggagctgct ggcacggtac gccgcacgga cccccgacgc cgtagccgtc acggatcctc 61920
ggacctcact cacctatgcg gagctggacc ggcgcgcgaa ccgtctggcg cagctgctcc 61980
gggcccgcgg caccgccacc ggcgacctgg tggggatctg tgccgaccgc ggcgtcgatc 62040
tggtcgtcgg catcgtgggg atcctcaagg caggtgccgc gtacgtaccg ctcgaccccg 62100
aacacccggc ggagcggacg gcgttcgtcc tggaggacgc gcggctgacc acggtggtga 62160
cggacagcgc ctatcgcccc cgcttccccg gcgtcccgca cgtggtgacg cccgacgacc 62220
cgcagctggc ccggcagccc gacacggcac cgcgcatcgt gctcgaccgg gacagcctcg 62280
cctacgcgat ctacacctcg gggtcgaccg ggaaacccaa ggccgtgctc atgccgggcg 62340
tcagcgccgt caacctgctg ctgtggcagg agcggacgat gggccgcgaa ccggccagcc 62400
ggaccgtgca gttcgtgacc agcaccttcg actactcggt gcaggagatc ttctccgcgc 62460
tgctcggcgg gacactcgtc atcccgccgg acgaggtccg gctcgacccg ccggggctcg 62520
cacggtggat ggacgagcag gcgatcaccc gcatctacgc gccgacagcg gtcctgcgcg 62580
ccctcgtcgg tcacgtcgac ccgcacagcg atcagctctc cgccctgcgg cacctctgcc 62640
agggcggcga ggcactggtc ctcgacactc ggctgcgcga gctctgccgc caccggcccc 62700
ggttgcgcgt ccacaaccac tacggtccgg ccgagagcca gctcatcacc gcgtacacgc 62760
tgccctccga ccccggcacc tggccggccg ccgcaccgat cggcccaccc atcgacaaca 62820
cccggatcca tctcctcgac gacgcgctgc ggccggttcc ggacgggatg ccgggccagc 62880
tctgcgttgc gggcatcggc ctcgcccgcg gatatctggc ccgcccggga ctgaccgccg 62940
agcggtgggt cccgggcggc gccaccggcg aggaacgcct gtacctcacg ggcgatctgg 63000
cgcgccgggc gccctccggc gacctcgact tcctcggccg gatcgacgac caggtcaaga 63060
tccgcggcat tcgcatcgag ccgggtgaga tcgagaacgc gctcgccgac gacccccgtg 63120
tcgcggacgc ggccgtgtcc gtacgggagg atccgcgggg cgagaagttc ctggcggcgt 63180
acgtcgtacc ggcgggcgga ccgtacggcg acggtttcgc cgcatcgctg cgcgacggcc 63240
tggccgcccg gctgcccgcc tatctcgtac cgtcctccgt cgtcacggtg gccgcgctgc 63300
cccggaccac gagcggaaag gtggaccggc gggcactgcc cgacccggag cccgcccggg 63360
ggtcggaccg gcaggccgct ccccgtaccg tcgccgaacg ggtggtgtgc cgcatcttcc 63420
aggacgtgct ggacgtcccc cgcgtcggtg ccgacgacga cttcttcatg ctgggcgggc 63480
attcgctgct cgccacccgg ctcgtttccc ggatccgtgc cgagttcggc gtcgacatcg 63540
cactgcggac gctcttcgac ggacggacgc ccgctgccct cgcccgcgcg gtggacacgg 63600
cgggacccgc cgccgtaccg cccccggtcc tgtccttccc cggtgcgggg cccgcacccg 63660
tcaccgcggc gcaggagcag atgctgcact cgcacggttc gctgctcgcc gcgccgtcct 63720
acacggtcgc cccgtacggg ttccggctgt acgggccgct cgaccacccc gccctcaacg 63780
cggcactgac ccggatcacg gcccggcacg agccgttgcg gaccgggttc cacggccgga 63840
cgcagatcgt ccatccgcct gccgaggtac gtgccgaggt ggtcgagccg gtgccgggcg 63900
gcgtccctga cgcggtccgg gttgcccgcg cggaactgac ccggccgttc gacctggtga 63960
acgggccgct gctgcgcgcc gtgctcctcc cgctgggtac cgaggaccac gtactgctgc 64020
tgatgctgca ccacctcgcc ggtgacggct ggtcgttcga cctcctggtc cgggagctgt 64080
cgggggcatc gcccgaactg ccggtgtcct atacggatgt cgcccggtgg gagcggacac 64140
ccgaggtcgt cgcagcgcgg gacaacgacc gcagctactg gagacggcag ttggaagggg 64200
cccgggcgcc ggagctgccc acgatccgcc cccgcggtac gacggccgcg ccggacgggc 64260
gggccttcct ctggaccctc gacgacacca cggtcgcggc ggcgcgccgg atctccggcg 64320
cccggaactc gacactgcag gagaccgtgc tcggcgcctt cgccctggtc gtggcggagg 64380
ccgcgggcac cgacgacctg ctcgtcacca cacccttcgc ggaccggggc caggccggga 64440
ccgagcatct catcggcttc ttcgcgaagg tcctcgcact ccgtgtcgac gtcggtgacg 64500
gcaacggcgg cacagcgtcg taccccgaag tcctgcggcg ggtcgggacc gcgatgaccg 64560
gcgcccacac ccatcagtcg gtgccctact cggcgatgcg cgcggccgat cccgcgctgc 64620
cgccggcccc actgtcgttc cagctcatca gcgcactcag tacggagctc cggctgcccg 64680
gactgcgcac cgagccgttt cccgtcgtcg ccgagagcgt cgacgacatc aacggcgaac 64740
tgtcggtcaa cctcttcgac gacggccgca ccgtgtcggg cgcggtcgtc cacgacgccg 64800
cgctgctcga ccgcgcggcc gtcaccgacc tgctcacccg ggtggagtcg acactccgtg 64860
ccgccgcagg cgacctcacc gtacccgtca ccggccccgt gggaagcgag tagccgtgcc 64920
cgaacaggac aaaacggtcg agtacctgcg ctggaccacc gcggaactgc agaaggcccg 64980
gagggaactc gccgcgcaca gcgagcccct ggcgatcgtc ggtatggcgt gccggctgcc 65040
gggcggggtg gcatcgccgg acgatctgtg gcggctgctc gactccggcg gcgacggcat 65100
cggcgcgcat cccaccgacc gcggctggga gacgtccgaa ggcggtcgcg gcggattcct 65160
caccggtgcg gccggattcg atgccgcgtt cttcgggatc agcccgcgcg aggccctcgc 65220
gatggacccg cagcagcgga tcgtcctgga aacgtcgtgg gaggcgctcg aacacgcggg 65280
catcgacccc catgcgctga acggcagcga taccggggtg ttcctgggag cgttcttcca 65340
ggggtacgga atcggcgccg acttcgacgg gtacggcacc accagcatcc atacgagcgt 65400
cctctccggc cgcctcgcct atttctacgg actggagggc ccggcggtca cggtcgatac 65460
ggcgtgctcg tcgtcgctgg tcgccctgca ccaggccggt cagtcgctgc gtaccgggga 65520
atgctccctg gcactggtcg gcggcgtcac ggtactggcg tccgcggcgg gcttcgcgga 65580
cttctccgag cagggcggtc tggcgccgga cggccggtgc aaggccttcg cggacgccgc 65640
ggacggcacc accttcgccg aaggctccgg tgtcctggtg gtggagcggc tttccgacgc 65700
cgaacgccac ggccaccgcg tcctcgcggt cgtacgcggc tccgccgtca accaggacgg 65760
cgcctccaac ggactctccg cacccaacgg accctcccag gaacgcgtca tccggcaagc 65820
cctcgccaac gcgggactca ccaccgccga catccacgcc gtggaagcgc acggcaccgg 65880
cacccgcctc ggggacccca tcgaagcgac cgcactgctc gccacctacg gacagagccg 65940
caccacaccg ctcctcctcg gctccctgaa gtccaacatc ggccacaccc aggccgccgc 66000
gggcgtcgcg ggcatcatca aaatgatcct cgccatgcac cacggcaccc tgccccgcac 66060
cctgcacgtc gacacaccgt ccacccacgt cgactggacg gcgggaggca tcgaactcct 66120
caccgaagcc cggccctggc ccacggctgc ggggccccac cgcgccggtg tctcctcctt 66180
cggcgtcagc ggcaccaacg cccacgtcat cctcgaaagc cgcccccagc cggaatccga 66240
gaccccgccc gacgcctacg ccgtgcccct ggtcgtctcc gcccggaccc ccgaggcgct 66300
cgaccggcag atcacccggg tacgcgcgtt cctccacgac catccgcgca cggaccgcgt 66360
ggccgtcgcg cagaccctgg cccggcgcac ctccttcgaa caccgtgccg tactgctcgg 66420
cgacacggtc gtcaccgcgg acccgaacgc caccctcggg ccggtcgtct acgtctactc 66480
gggacagagc accctgcacc cggacaccgg caaccggctg gcggccgcct acccggtctt 66540
cgcggacgca cggcgcgagg cgctcggtca cctcgacccg gagccgggtc cggccaggca 66600
cttcgcccac caggttgccc tcaccgcact gctgcggtcc tggggcatca ctccgcacgc 66660
ggtcatcggc cactccctcg gtgagatcac cgccgcgtac acggccggaa tcctgccgct 66720
gcgcgacgcg tgcacgctcc tgaccgtccg cagccgcctc atggacgaac tcccggaggg 66780
cggcgcgatg gtcaccgtcc tcacaggcga ggaggaggcg cgccgggcgc tgcgccccgg 66840
agtggagatc gccgccgtca acggccccca ctccgtcgtg ctctccggcg acgaagaagc 66900
cgtactcgac gtcgcccagc ggctcggcat ccaccaccgg ctgccgacgc gccacgccgg 66960
gcactccgcc cggatggatc cgctcgtcgc gccgctgctc gaagccgccc gggggctgac 67020
gtaccaccag ccccgcatca ccgtcccctc gggccccacc acggccgagt actgggcgcg 67080
ccaagtccgc aacccggtgc gcttccagga gcacaccgaa cagttccccg gcgccacgtt 67140
cctggagatc gggcccaacc aggacctctc cccgatcatc gacggcattc ccacccagac 67200
ggggacgccc gacgagaccg cggcgctcca caccgccctc gcgcgtctgt acacccgtgg 67260
ggtcgcggtc gactggacga ccgtactcgg cagtgaccgc gcacccgtcg cgctgccccc 67320
gtacccgttc cagcaccagg actactggct gcgggccacc gcccgggcgg atgtgaccgg 67380
cgcggggcag gaacaggtcg cgcacccgct gctcggtgcc gcggtcgcgc tccccggcac 67440
cggcggaaac gtcctgaccg gacggatctc cctggcctcc catccgtggc tcggcgggca 67500
cgccgtcaac ggggccgtgc tcctgcccgg tgcggcgttc ctcgaactcg cggtgcgcgc 67560
cggtgacgag gccggatgcg atcttctcca cgaactggtg gtcgagaccc cgctcgtgct 67620
gccggagagc ggctccgtcg cgatctccgt cgaggtggcc gagcccgacg aggcggggcg 67680
ccgcgcggtg accgtccacg cgcgcgccga cggtgccggc ccgtggaccc accacgccac 67740
cggcttcctc ggcaaggcac ccaccgggac cgcagcgacc gcggtggcgg acccggcgcc 67800
ctggccgccc gccggggccc tgccggtcga cgtggacgac gtctacgagc ggttcgggag 67860
catcggatac gcatacgggc cgccgttcca ggggctgcgg gcggcgtggc gtgacggcga 67920
caccctccac gccgaggtcg cgctccccga cgatcaggcg gcggacgccg cccggttcac 67980
cctgcacccc gcgctgttcg acgccgcgtt ccaggccggt gcgctgtacg cgctcgacac 68040
gcccggggcg acggcccggc tgccgttctc gttccaggac gtccgcatcc atgcgtccgg 68100
ggccacacgg gcacgcgtca ccgtcggccg cgacggtgat cgcagcaccg tacgcatgac 68160
cggcgaggac ggaaagcccg tggccgtcgt cgggtcggtg gtgtcgcgcc cgtacaccgg 68220
tggatccggc cccggcgacg acctgctgcg cccggtctgg accgagctgc cgatgcccgt 68280
accttccgcg gacgatccgc gcgtggagat tttcgctgcg gaccccgtcg acgacgaccc 68340
gaccgtggcg gtgagggagc tgacgggccg cgtcctcgac gccctgcggc gccggctgtc 68400
caccaccgac gagatgaccc tcgtcgtccg gaccggcacc ggcccggcgg cggccgccgc 68460
ggcgggcctg gtccgctcgg cacaggcgga gaaccccggg cggatcgtcc tcgtcgaggc 68520
gcccccggac actcctgcgg acctcctcgc cgcgtgcgcc gcactggacg aaacgcagct 68580
ggccgtccgg gacggtgtgc tctacgcacg gcggctggta cggatgtccg acccggtgca 68640
cggcccgctg cccctgccgg acggcgactg gctgctcacc cgctccgcct ccggagtcct 68700
gcacgacgtc acgctgaccg ccgacgacgg gccccgccgc gcactcgaag ccggcgaggt 68760
ccgcatcgac gtccgggccg cgggcctgaa cttccgggac gtcctgatcg cgctggggac 68820
gtacgagggg gcgaccgcca tgggcggtga ggccgcgggc gtcgtcgtgg acaccgggcc 68880
cggcgtgacc gacctctccc ccggtgaccg ggtcttcggc ctgacccggg gcggtatcgg 68940
cccgaccgcc gtcacggacc ggcgctggct ggcgcggata cccgacgggt ggagcttcac 69000
cacggcggca tccgtcccgg tggtgttcgc gaccgcctgg tacggcctgg tcgacctcgc 69060
ggggctgcgc gcgggcgaga aggtcctcgt gcacgcggcc accggcggtg tcggcatggc 69120
cgccacgcag atcgcccggc acctcggcgc cgaggtctat gccaccgccg gtaccgggaa 69180
gcatcatgtg ctgcgcgccg ccgggctgcc cggcacgcat atcgccgact cacggacgac 69240
ggcgttccgg accgtcttcc cgcggatgga cgtcgtcctc aactccctga ccggcgagtt 69300
catcgacgct tcactcgaac tcctggacac ggacggccgg ttcgtcgaga tgggccgcgc 69360
cgagctgcgc gatccggaca ccgtcacgcc cgcctatctg ccgttcgacc tcctcgacgc 69420
gggcaccgac cgcatcggcg agatcctggg cgaactcctc gggctgttcg aggcgggcgc 69480
gctcggtccg ctgccggtcc gcgcctggga cgtccggcag gctcggaccg cgctcgaccg 69540
gatgagccga gcccgccaca tcggcaagaa cgtcctcacg ctcccccggc cgctcgaccc 69600
ggacggcgcg gtcgtcatca ccggcggttc gggcaccctc gccggcatcc tggcccgtca 69660
cctcggcggg cggcacgtct atctgctgtc ccggacggcg ccgccggagg gaacacccgg 69720
cacctatctg ccgtgcgacg tcggcgaccg gcagcaactg gcgacggcac tggggcggat 69780
cgaccggccg atcaccgccg tggtgcacac ggcgggcgcg ctggacgacg ccaccgtccc 69840
ttcgctcacg cgcgagcact tcgacaccgt cctgcgcccg aaggccgacg gcgcctggca 69900
tctgcacgaa ctcaccaagg accaggacct cgcggcgttc gtgctctact cgtcggccgc 69960
cggggtgctc ggcaacgcgg gccagggcaa ctacgccgcg gccaacgcct tcctcgacgc 70020
gctcgccgaa cagcgccacg cggcgggcct gcccgcgctg tccatcgcct ggggactctg 70080
ggaggacacg agcgcgctca ccgccgggct cggtgaggcg gaccgggacc ggatgcggcg 70140
gagcggattc cgtacgatca gcgcgcgacg gggcatgcgt ctgtacgagg cggcggggcg 70200
cagcgggagt cccgtggtgg cagctgccga actcgacgag gcgccggacg taccgctgct 70260
gcgggggctc cggcgtacga ccgtgcggcg tgccgccgtc cgggagcgct ccctcgccga 70320
ccggctcgcc gcgctgccgg acggcgagcg cgcggatgca ctcctcgcgc tcgtccggga 70380
ctgtacggcc accgtgctcg gccatctggg taccgaaggg attccgccgg ggtcgacgtt 70440
caaggagctc ggcatcgact cgctgaccgc ggtccagctc cgcaacgggc tcaccacggc 70500
gaccggtgta cgcctcaacg ccacggcggt cttcgacttc ccgacgcccc gggcgctcgc 70560
ggcgaagctc ggtgacgagc tgaccggggt ccgcgcggcc gtcacggccc ccagcgcggc 70620
cacggacgtg gcgcacgacg aaccactggc gatcgtgggc atggcctgcc gtctgccggg 70680
cggggtcacc tcgccggagg agctgtggcg gctcgtcgtg tccggcaccg acgccatcag 70740
cgagttcccc acggaccgcg actgggacat cgacgccctc tacgaccccg accccgacgc 70800
cgtcggcaag acgttcgtcc ggcacggcgg cttcctcggc agtgcgaccg gcttcgacgc 70860
ggcgttcttc ggcatcagtc cgcgcgaggc cctggccatg gatccgcagc agcgggtcct 70920
cctggagacg tcctgggagg cgttcgaaag tgccggactg accccggact cggcccgggg 70980
cagcgacacc ggcgtcttca tcggcgcgtt ctcctacggc tacggcacgg gtgcggatac 71040
caacggcttc ggcgcgacgg gctcgcagac gagcgtgctc tccggacggc tctcctactt 71100
ctacggtctg gaggggccgt cggtcaccgt cgacaccgcc tgctcgtcgt cgctggtcgc 71160
gctccaccag gccggtcagt ccctgcgtac cggggagtgt tccctggcgc tggtcggcgg 71220
cgtcacggtg atggcgtccc ccagcggctt cgtcgagttc tcccggcagc gcggtctcgc 71280
accggacggg cgggcgaagg cgttcggcgc gggcgcggac ggtacgagct tcgccgaggg 71340
cgccggtgtc ctggtcgtgg agcggctgtc cgacgcggaa cgccacgggc gtaccgtcct 71400
cgcggtcgtc cgcggctccg cggtcaactc cgacggcgcc tcgaacggtc tgtcggcgcc 71460
caacgggccg tcgcaggagc gggtcatccg gcaggccctc gcgaacgcgc ggctcgaacc 71520
ggcggacgtc gacgcggtcg aggcccatgg caccggcacc cgcctcggcg accccatcga 71580
ggcgaccgcg ctgctcgcgg cgtacgggca ggaccgggcg gagcccctgc tgctcggctc 71640
gctgaagtcg aacatcgggc atgcgcaggc cgcgtccggt gtggccggga tcatcaagat 71700
ggtgcaggcg atccggtacg gggagctgcc gccgacgctc cacgcggacg agccgtcgcc 71760
gcatgtcgac tgggcgtccg gcgccgtcga gctgctgacg tcggcccggc cgtggccgcg 71820
gaccggccgt ccgcgccgtg ccgccgtctc gtcgttcggg gtgagcggca cgaacgccca 71880
tatcgtcctg gaggccgggc cggaccctgc accgcccccg gcggcaccgg taccgacacc 71940
gacaccggcc gaggggctgc cgctgctggt gtcggcgcgg tccgcggagg cactcgacga 72000
gcagatcgcg cgcctgcgcg cctatctcgg ctccgctccg gacatcgacc gggcggcggt 72060
ggcgcagaca ctggcccggc ggacgcactt cgcccaccgt gccgtgctgc tcggtgactc 72120
cgtcgtcacc gctcccccgg cggaggaagc cggggagctg gtcttcgtct actccggcca 72180
gggcacccag catccgtcga tgggcgagca cctcgccgcc gccttccccg ccttcgccgg 72240
ggcgtggcgg gacgcgctcc accggctcgg tgaccccgat ccccacgacc ccacgcgaag 72300
ccagcacacg ctcttcgccc accaggcggc gttcacctcc ctgctggagt cctggggcat 72360
cgccccgcac gcggtgatcg gccactccct cggggagatc accgccgccc acgcggccgg 72420
gatcctgtcg ctcgacgacg cgtgcaccct ggtcacgacc cgtgcccgcc tgatgcacac 72480
gctgccgccg cccggtgcca tggtcaccgt gctgagcagt gaggaggagg cgcggcgggc 72540
actccggccg ggcgtggaga tcgccgcggt caacggcccc cactccgtcg tgctctccgg 72600
cgacgaggac gcggtgctcg atgtcgcgca ggggctcggc atccaccacc ggctgcccgc 72660
gccgcacgcg ggacactccg cgcatatgga gccggtggcc gccgagctgc tcgcgaccac 72720
ccggcagctc ggctacggca ggccccgcgt cgccgtcccc aacgacccga ccaccgccga 72780
gtactgggcc gagcaggtcc gtaagccggt gctgttccat gagcacgcgc agcggtatcc 72840
cgatgcggtg ttcgtcgaga tcggccccgg gcaggatctc tcaccgttgg tcgacggcat 72900
cgccctgcag aacggcacgg cgaacgaggt gcaggcgctg tacacagcgc tcgcccgcct 72960
ccacacgcgg ggcgcgacgc tcgactggcc cctgatcctg ggcggtgacc cgcgtcacga 73020
cccggacgtt ccggggtacg ccttccagcg acgcgcctac tggatcgcat cggcgcccgc 73080
ggccacggcc gaagcgggcc accccgtcct cggcaccgga gtcgccctcg ccgggtcgcc 73140
cggccgggtg ttcacgggca ccgtcccggc ggacggggac cgcgcggtgt tcctcgccga 73200
actggccctg gccgccgcgg acgcggccga ctgcgccacg gtcgaacgtc tcgacatcac 73260
cagcctgccc ggcggatccg ccgggggccg ggccaccgtg cagctctggg tcggtgagcc 73320
cggggcggac ggcaagctcc cgttcacggt gcacacccgt gtcggcggcg gcccgtggac 73380
gctgcacgcc gagggtgtgc tccgccccgg cggcgtaccc gtgcccgatg ccttcgacac 73440
ctcgtggccc ccgccgggcg cggtgcccgc cgacgggtcg cccggggcgt ggcggcgcgg 73500
ggacgaggtg ttcgtcgagg cggaactaga cggatcgacc ggatcgaccg gagaggccgg 73560
atcagccgac tcgaccggct cgaccggctt cgtggtccac cccgatctgc tcgacgcggt 73620
cttctcggcc gtcggcggcg gccgccggcc gaccgcctgg cgcgatctcg cggtgcacgc 73680
gtcggacgcc accgtgctgc gtgcccgtct cacccgccgt acgggcggtg ccgtggaact 73740
cgccgccttc gacggtgccg gtctgccggt actcagcgcg gcctcggtga ccttgggcga 73800
ggtcgcatcg gcgggcgatg cgaacggcct gttcgggttg gagtgggtgc cggtggcgga 73860
agccgtctac gacgggaccc tgcccgacgg ctacaccctc atcaccgccg cacaccccga 73920
cgagccggac gacctcaccg acctcaccga tatgcccgcc ctcacccaag cccgcaccac 73980
ccgcaccctc accgccctcc aacaccacct caccaccacc caccacaccc tcatcgtcca 74040
caccaccacc gaccccgcag gcgccgcagc caccggactc accaaaaccg cccagaacga 74100
acacccaaac cgcatccaca tcatcgaaac cacccacccc cacacacccc tccccctcca 74160
ccagatcacc accctcaacc aaccccacct ccgactcacc caccacaccc tccacacacc 74220
ccacctcacc cccctccacc acacccccac ccccacacca cccctcaacc cccaccacgc 74280
catcctcatc accggcggct ccggcaccct cgccggaatc ctcgcccgcc acctcaacca 74340
cccccacacc tacctcctct cccgaacacc accacccccc accacccccg gcacccacat 74400
cccctgcgac ctcaccgacc cccaccaact cacccaagcc ctcacccaca taccccaacc 74460
cctcaccgcc atctaccaca ccgcagccac cctcaacgac gccaccctcc acaacctcac 74520
cccccaccac ctcaccacca ccctccaaac caaagcccac accgcctggc acctccacca 74580
acaaacccaa caccaccccc tcacccactt catcctctac tcctcagcag ccgccaccct 74640
cggcagcccc ggacaagcca actacgccgc cgccaacgcc ttcctcgacg ccctcgccac 74700
ccaccgccac caccaaggac aacccgccac caccatcgcc tggggcatgt ggcaaaccac 74760
caccaacctc accacccaac tcacccacac cgaccgacag cgcatccgcc gcagcggctt 74820
cctgcccatc tcggacgaag aaggcatgga cctctacgac gcggctgtcg cctccggcaa 74880
ggatttcgtg ctggcggccc cgatggaccc ggcgcagctg gcatccggtg acgtaccgcc 74940
gatcctgagc ggtctgcgcc gaggcgcgcg ccgtaccgcc cggcccgggc agacgttcac 75000
ccagcggctc gcggacctgc ccgacgccga ccgtgagacg gccctgctca ctctggtgtc 75060
ggacgccacc gcgaccgtgc tcggccatgc cgacgcctcg gacatcggac cgaccagggc 75120
gttcaaggat ctcggcatcg actcgctcac cgccatcgag ctgcggaacc ggctcgcgga 75180
ggcgaccggg ctccggctga gctccacgat ggtgttcgac catccgacac cgcgggtgct 75240
ggccacgaag ctccgcgccg atctgttcgg cacggacgcg ccgttgcccg tacgaaccgc 75300
acaggcccac cacgacgaac ccctcgcgat cgtcggcatg gcctgtcgtc tgcccggcgg 75360
cgtctcctcg cccgagggcc tgtggcggct cgtcgagtcc ggcacggacg cgatcaccga 75420
gttccccgcc gaccgcggct gggacatcga gtcactgttc gacccggacc cggacgcgcc 75480
cggcaagacg tacgtccggc acggcggctt cctccccgag gccgcggact tcgatgccgc 75540
gttcttcggg atcagcccgc gcgaggcatg ggccatggac ccgcagcagc gtgtcatcct 75600
cgaaacggcc tgggaggcgt tcgagcacgc gggcatcgtc ccgggcgcac tgcggggcag 75660
cgacaccggc gtgttcatgg gcgcgttctc ccacgggtac ggcgcaggcg tcgacctggg 75720
cggcttcggc gccacggcca cccagaacag cgtgctctcc ggtcgtatct cctacttctt 75780
cggcatggaa ggaccggccg tcaccgtcga cacggcgtgc tcgtcgtcac tggtcgcgct 75840
ccaccaggcc gcacagtcgc tccgggccgg ggactgttcc ctggcgctgg ccggcggggt 75900
cacggtcatg cccacaccgc tgggatacgt cgaattctgc cgccagcgcg gactcgcacc 75960
cgacggccgg gccaaggcgt tcgcggacac cgccgacggc accagcttct cggaaggcgc 76020
cggtgtcgtc atcgtggagc ggctctccga cgcccggcgc aacggacaca ccgtcctcgc 76080
gctcctgcgc tcctcagccg tcaaccagga cggtgcctcc aacggcatct ccgcgcccaa 76140
cggcccgtcc cagcaggccg tcatccgcag ggcactcgac cgggcggggc tcgccgccgc 76200
cgacgtcgac gtggtcgagg cgcacggcac gggtacgccc ctgggcgacc ccatcgaggc 76260
acaggccatc atcgcgacgt acgggcagga ccgcgagaca cctctctacc tcggttcggt 76320
caagtcgaac atcggccaca cccagaccgc ggcgggcatc gcgggtgtca tcaagatggt 76380
gatggcgatg cggtacgggg tgctgccgag gacgttgcac gtcggtgagc cgtcgtcgca 76440
tgtggactgg tcggcggggt cggtggaggt gctgacggag gccaggccgt ggcccgagtc 76500
ggaccgtccg cgccgggcag gcgtgtcgtc actcggcatc agcgggacga atgcgcatgt 76560
gattttggag agtgcgccgg aggtttcggt ctctgccgct gagcccgagt ccggtggttt 76620
ggtgccgttg ccggtgtcgg ctcgttcggg tgtgggtgtg ggtgtgttgg tagagcgggt 76680
gggtgggttg gtggggggtg ggtgtgatgt gggtgtggtg gcggatgggt tggtgcgggg 76740
gcgtgcggtg ttcggtcatc gggcggtgtt gctgggggat ggtgtggtga ggggtgtggc 76800
gggtgagggg ttgcggacgg tgttcgtgtt cccggggcag gggtcgcagt gggtgggaat 76860
gggccgcgaa ctcgccgaag tgtcacctgt ctttgcggcg cggatgggtg agtgtgcggc 76920
ggcgctggca cctcatgtgg actggtcgtg ggaggaggct ctggggtcgc cggagttgct 76980
ggggcgggtg gaggtggtgc agccgttgtc gtgggcggtg gcggtgagtc tggctgcgct 77040
gtggggggcg catggtgtgg tgccggatgt ggtggtgggt cattcgcagg gggagattgc 77100
tgcggcgtgt gtggcgggtg cgctgagcct ggaggacggg gcgcgggtgg tggctttgcg 77160
gagccgggtg atcggtgccc ggctggcggg gcggggggtg atggcatcgg tcgcactccc 77220
cgccgccgac atcgagacgg tggagggggt gtggatcgcg gcccgtaacg gaccgtcgtc 77280
gaccgtgatc gcgggagatg cgcaggccgt ggagggggtt ctggcccggt acgaaactgc 77340
gggggtacgg gttcggcgga tcgcggtcga ctacgcctcc cacacccccc acgtcgaggc 77400
catcgagaac gaactggccg aagcattaac cggtattgcg gcccggaccc ccagcatccc 77460
ctggtggtcc accgtcgaca gcggctgggt caccggaccg gtcgacggcg gctactggta 77520
ccgcaacctc cgtcaaccag tagccctgga caccgccatc acagaactcg acggctccct 77580
gttcgtcgag tgcagtgcgc atcccgtgct gctgcccgcc atcgaccagc aacgtaccgt 77640
cgcctcactc cgcaccgacg acggcggcgg agaccggttc accaccgccc tggccgaagc 77700
ctgggtccac ggcgcagccg tcgactggac caccatcgtc ccgcccaccc cggaacgact 77760
cctcgacctc cccacctacc ccttcgacca caagcgctac tggatagaag cggccggccc 77820
caccgatctc ggcgccctcg gactcaccgc caccgcgcac tccatgctgg ccgcgaccac 77880
cgcgctgccg acgaacgacg gcaccgcgct caccggccgg atctccctgc gcacccatcc 77940
ctggctggcc gaccacgccg tccacgacac ggtacttctc ccgggtaccg cgttcctgga 78000
gctggtgatc cgcgccggtg acgagaccgg ctgcgacacc atcgacgagc tgatcatcga 78060
aacaccgctc gccctgcccg tcaccggagc cgtcgacctc accgtcaccg tcgaccggcc 78120
cgacgaggcc ggacgccgcc ccgtgaccgt ccacgcacgc cccgaaggaa ccggcacctg 78180
gacccgccac gccaccggaa ccctcaccac cagcggcacc accgccccgg acgcgttccc 78240
gcaatggccg ccgaccggta ccaccgccgt cgacatcggg gagttctatc cgcggctcac 78300
cgcgctgggc taccggttcg gccccgcttt ccgcgggctg cgggcggcct ggcgcgacgg 78360
cgacaccgtg tacgccgagg tggcgctccc cgaggaccgt accgccgacg cggaacgctt 78420
cggtgtccat ccggccctgc tcgacgccgc cctgcagagc ggcagcctcc tgatgctcga 78480
atccgacggc gcgcagggtg tgcaactccc gttctcctgg cacggcgtcc gcttccatgc 78540
gaccggggcg acctcgctgc gggtcgcgat cacacccggc cccgacggcc tccggctgca 78600
cgccgcggac agcggcaacc gatccgtcgt gtccatcgac gcgctggtca cccggccccc 78660
ggcgggcctc gcaccccccg atccggtgct ccgcgtcggc tggagcaccg tgcccgtacc 78720
ggccgacgtc gtcccgtgcg acgcggatgt gctgacgctg cacagcaacg acgccgaccc 78780
gctccaggag acccgggacc tcaccactcg tgtgctcgac accctcctcc gggccgagcg 78840
caccctgatc gtccaagtca ccggcggcct cgccgcgatg gcggcggcgg gcctcgtacg 78900
caccgcgcag aacgagcggc ccggccgctt cttcctcgtc gaaacggatc ccggggaggt 78960
cctggaccct gcacggtgcg ccacgatcgc ggcgctcggc gagccgcggc tgcgcctgcg 79020
cggcgaccgc tacgaggcag cccggctcat gcgggccgca ccggccctga cccttcccga 79080
gaccggatcg tggcagctgc gccggtccgc caccgggtcg ctcgacgacc tcgccgtcgt 79140
tgccaccgaa gaaccggacc ggccgctcgc ggccggagag gtgcggatcg cggtacgggc 79200
cgcgggcctg aacttccgtg acgtcacggt ggcgctgggc gtgatctccg atgaacggcc 79260
gctcggcagt gaagccgccg gggtcgtcct ggagaccggc cccggggtgc acgacctggt 79320
acccggcgac cgggtcatgg ggatgctcgc gggcgccttc gggccggtcg cgatcaccga 79380
ccggcggctg ctgggccgga tgcccgacgg ctggacgtac gggaccggcg catccgtcct 79440
gaccgccttc gcgacggcgt ggtacggcct ggtggatctg gcggggctgc ggcccggtga 79500
gaaggtcctg atccacgcgg cggccaccgg tgtgggcgcg gcagccgtcc agatcgcccg 79560
gcatctgggc gccgaggtct acgccaccgc ctccacggcg aaacggcacc tcctggacct 79620
cgacggcccg cacaccgccg actcccgcag caccgcgttc gccaccacct tcccccccgt 79680
cgacgtcgta ctcaacgcgc tcaccggcga actcctcgac gcctccgtcg ccctcctcgc 79740
acccggcggc cgcttcatcg agatgggcaa aaccgacctc cgccacgaca tccagcagcc 79800
cttcgacctc atggacgccg gacccgacca cctccagcag atcatcaccc gactcctcga 79860
cctcttcacc caaggcaccc tccaccccct ccccgtgacc gttcacgaca tccggcgggc 79920
gcgggaggcg ttcggctgga tgagcagcgg acggcatacg ggcaagctgg tgctcacggt 79980
gccgcggccg ctcgaccccg acggcgcgat cgtcatcacc ggcggctccg gcaccctcgc 80040
cggaatcctc gcccgccacc tcaaccaccc ccacacctac ctcctctccc gaacaccacc 80100
accccccacc acccccggca cccacatccc ctgcgacctc accgaccccc accaactcac 80160
ccaagccctc caccagatac cccaacccct caccggcatc ttccacaccg cggccaccct 80220
cgacgacacc ctcatcgacc acctcacacc cacccgcatc cacaccgtcc tccagcccaa 80280
agccgacgcc gcctggcacc tccaccacca cacccgcaac accgacctcg ccgcattcgt 80340
cctctactcc gcggtcgccg gggtcatggg gagccctggc cagggcaact acgtcgcggc 80400
gaacgcgttc ctggacgcgc tcgcggagca ccggcacgcc atgggtctgc ccgcgcagtc 80460
tctcgcctgg ggtatgtggg cggacgtcag cgcgctgacg tcgaagctca ccgccgcgga 80520
ccgtgaacgc atccggcgcg ccgggttccc gccgctcagc gctgcggacg gcatgcggct 80580
gctggactcg gcggcgcgta ccccggagcc ggtggtcgtc gccacgacgg tcgacaccgc 80640
acggctcgac gggccggtcg cgccgctgct ccgcagcctg gtggcccatc ggtccgggcc 80700
ggtgcgcggg gtcgcccgga acaccgggga cgagccgctg gcggtacgtc tcaccgggcg 80760
caccgtcacc gaacagcggc gcgtgatgca ggacatcgtg ctccgccagg cggccgcggt 80820
gctggcctac ggcccggacg agcaggtcgc ggtggaccgg ccgttccgtg aactcggttt 80880
cgattcgctg accgcggtcg acctgcgcaa ccggctcgcg gccgagacgg ggctgcggct 80940
gccgaccacg gtggtgttca gccatccgac ggcgcaggcg ctcgccgggc atctgctgga 81000
actgctcggc gctcccgcca cccggtccgc ggcggactcc gtgcccgccc cggccgtacg 81060
ggaccgggac cgggaccggg accgggaccg ggacgagccg atcgcgatcg tggcgatggc 81120
ctgccgtctg cccggtggcg tggcatcacc cgaggatctg tggcggctcg tcgagtccgg 81180
caccgatgcg atcaccgtgc cgcccggcga ccgcggatgg gatctcgacg cgctgtacga 81240
cgcggacccc gacgcggtgg gcaaggcgta caacctgcgg ggcggcttcc tggacggggc 81300
ggcggagttc gacgcggcgt tcttcggcat cagcccacgg gaggcgctgg gcatggaccc 81360
gcagcagcgc ctgctgctgg agaccgcgtg ggaggccgtc gagcgcggcc ggatcgaccc 81420
cgcgtcgctg cacggccggg aggtcggtgt ctacgtcggc gcggccgcgc agggctacgg 81480
cctcggtgcc gagcaccccg agagccccgg gcacccccag tacaccgagg gcaatgcggt 81540
caccggcagc tccacgagtc tgctgtccgg gcggatcgcc tacgtcctcg ggctggaggg 81600
accggccgtc accgtcgaca cggcgtgctc gtcgtcgctg gtcgccctgc atctggcctg 81660
tcagggactg cgcctgggcg aatgcgagct ggcactcgcg ggcggcgtct ccgtactcag 81720
ctcgccggcc gctttcatcg agttctcccg ccagcgcggt ctggcggcgg acgggcgctg 81780
caaatcgttc ggctcgggtg cggacggtac gacgtgggcc gagggagtgg gcgtactggt 81840
cctcgaacgg ctgtcggacg ccgagcggct cgggcacgcc gtgctcgccg tcgtccgcgg 81900
cagcgccgtc acgtccgacg gcgcctccaa cgggctcacc gctccgaacg gcctctccca 81960
gcagcgggtc atccgcaagg cgctggccgc ggccggtctg accgccgccg atgtggacgt 82020
cgtcgaggga cacgggaccg gcacccggct gggcgatccg gtcgaggcgg acgccctgct 82080
cgcgacgtac ggacagaacc gccgggaccc ggtccgcctc ggctcgctga agtcgaacat 82140
cgggcatgcg acggccgcgg ccggggtcgc gagcgtcatc aagatggtgc aggcgatcgg 82200
ggcgggcacc atgccgcgga cgctgcacgc ggacgagccc tcgcccgccg tcgactggac 82260
cacggggcgg gtggccctgc tcaccgagaa ccggccctgg ccggatgacg agagcccgcg 82320
gcgggcggcc gtctccgcgt tcgggctcag cgggacgaac gcgcacctcg tactcgaaca 82380
gcaccgtccg gcgcccgccg gaccccggcc ggcccgtgcg gagccccggc cggtgccgtg 82440
ggtgctgtcc gcacggtcgc cggccgcgct gcgggcgcag gccgcccggc tccgcgacca 82500
tctggcggcg gtcccggcag cggacccgct ggacatcgga tacgcgctgg ccaccagccg 82560
cgcccggttg ccgtaccgcg ccgcggccgt cgccaccgac accgacgggt tccgtaccgt 82620
gctggacggc atcgcggacg gcgtcgacgc gcccggagcc gtcaccggga ccgcccggga 82680
ccgccgcatc gccttcctct tcgacggcca gggcacccag cgcacgggca tggggcgcga 82740
gctgcaccgg agtttccccg tcttcgccgc cgcctgggac gaggtgtccg acgccttcgc 82800
cgggcagctg gaacactccc cgacggacgt cttccacggt gcgcacggtg agctcgccaa 82860
cgacaccctg tacgcgcagg ccgggctgtt caccctcgaa gtggcactgc tgcggctcct 82920
ggaccactgg ggtgtgcgcc cggacgtcgt cgtcgggcac tccgtcgggg aagtcaccgc 82980
ggcccatgcg gcgggggtgc tcacgctcac ggacgccacc aggctgatcg tggcccgtgg 83040
ccgggccctg caggccctgc cgccgggggc catgaccgcg gtcgacggca gcctcgcgga 83100
ggtcggtgcc ttcaccggct ccaccgatct ggacgtcgcc gcggtcaacg gccccaccgg 83160
cgtggtcctc acgggctcac cggacgacgt ggccgcgttc gaacgggagt gggcggcggc 83220
cgggcggcgc gcgaaacggc tggacgtcgg gcacgcgttc cactcgcggc atgtcgacgg 83280
cgccctcgac gacttccgta ccgtcctcga atccatcccg ttcggcgcgg cacagctgcc 83340
ggtggtgtcc acgacgacgg gccgtgaggc ggcggacgac ctcgcgaccc cggaacactg 83400
gctgcgccat gcgcgccggc cggtgctctt cgcggacgcc gtcctggagc tcgcggaccg 83460
cggtgtgaac atgttcgtgg ccgtcggacc gtccggggct ctcgcttcgg ccgcgtcgga 83520
gaacaccggc ggggacgccg ggacctacca ctcggtgctg cgtgcccggg cgggcgagga 83580
gaccgcggcg ctgaccgccg ccgccgaact gcacgtacac ggagccccgg tggacctggc 83640
cgtggtgctg gacggcggac gcccggtgga cctccccgtc tacccgttcc agcaccgcca 83700
ctactggctg gcatccggcc cgggcaggag tacgccgacg gcctccccgg acaccgggtg 83760
gggcgaggag cccgaagcgg gggacctcgg catcgccgag atcgtccggc ggagtaccgc 83820
ggcgctgctc ggcgtcaccg accccgccga cgtcgacacg gactcgacgt tcttcgcact 83880
cggcttcgac tcgctggcgg tgcagcgcct gcgcaaccgg ctcacctccg caaccggtct 83940
cgacctgccg acgtccgtgc tgttcgacca cgacaccccg gccgccctca ccgcctatct 84000
ggaggaccgg ctcggcgacg gcgcggacga cgacccgccc accgtgctcg aactcctgac 84060
ggagatggag tcgctcgacg ccgcggacat cgcggcgaca cccgccccgg agcgtgcggc 84120
catcgccgat ctcctcgaca ctctctcccg cgtctggaag gaccaccgat gagcaccgac 84180
acacccgacg agacgacgcc cgccggacgc tgcccgttcg cgatccagga cggccaccgg 84240
gcgatcctgg cgagcggcac ggtgggctcg ttcgatctgt tcggcatcca gcactggctg 84300
gtcgccggtg ccgaggacgt caaactggtc accaacgacc cgcggttcag ttcggccgca 84360
ccgtccgaga tgctgcccga ccggcgcccc ggctggttct ccggcatgga cctgccggag 84420
cacagccgct accggcagaa gatcgccggg gacttcacgc tgcgttccgc gcgcaagcag 84480
gagaccttcg tcgtcgaggc ggccgacgcc tgtctggacg ggatcgaggc cgccgggccc 84540
ggcaccgatc tgatttccgg gtacgcgaag cagctcccct ccctcgtcat caacgcgctg 84600
tacgggctca ccccggagga gggagcggta ctggaaacac gcatgcgcag catcacgggc 84660
tcgaccgacc tggacagcgt gaagacgctg acggacgact tcttcgtcca tgccggggag 84720
ctggtccgcg ccaaacgcga cgagcagggc gacgacctgc tccaccgcct cgcctccacc 84780
gctgacggcg agatctcgct gagcgacgac gaggcgacgg gagtgttcgc gactctgctg 84840
ttcgccgggc acgactccgt acagcagatg gtcggctact gcctctacgc cctgctcagc 84900
caccccgaac agcaggcggc cctccgtgca caacccgatc tgatcgacca cgcggtcgag 84960
gagatgctgc gcttcctgcc ggtcaaccag atgggagtac cgcgcgtctg cgtcgaagac 85020
gtcgacctgc acggcgtacg gatcagcgcg ggcgacaacg tgatcccgct ctactcgacg 85080
gcgaaccgcg acccgaggct gttcctggac cccgatgtgt tcgacgtacg gcgtccgccg 85140
gagggcaact tcgcgttcgg ccacggcatc cacaagtgcc ccgggcagca catcgcccgg 85200
ctgctcatca aggtcgcgtg cctgcggttg ttcgaacgct tcccggacgt ccgcctcgcc 85260
ggcgacgtac cgatgaacga gggtctcggg ctgttcagcc cggccgaact gcggatcacc 85320
tggggtacgg cgtgaccccg gtgccggaga cactgcgact gccgaacggg acgacggtct 85380
cgcacatcaa cgcgggcgag gcgcagttcc tgtaccggga gatcttcacc gagcgctgct 85440
atctgcgcaa cggcatcgaa ctgctcccgg gtgacgtggt cttcgacgtc ggcgccaata 85500
tcggcatgtt cacgctcttc gcccatctgg agcggcccgg agtgaccgtg cacgccttcg 85560
agcccgcgcc gatgccgttc gccgcgctac gggccaacgt gctgcggcac ggcgtcccgg 85620
gccgggtgga ccagtgcgcg gtctccgacg aggccggggt cagcaggatg acgttctacc 85680
ccgacgccac cctgatgtcg ggcttccaca cggatcccgc gagccgcaga gagctgttgc 85740
gtacgctcgg cctcaacggc ggctacagca ccgaggacgt cgacatcatg cttgcccaac 85800
tgcccgacac gagcgaagag atcgagacca cgacggtccg gatctccgac gtcatcgcgg 85860
agcgcggcat cacggcgatc ggtcttctga agatcgacgt cgagaagagc gaacggcggg 85920
tcctcgccgg catcgaggac gccgactggc cccgtatccg ccaggtcgtc gccgaggtcc 85980
acgacaccga aggcgcgctc ggcgaagtcg tcgcgctcct gcacggccat ggcttcaccg 86040
tggtcaccga gcaggaaccg ctgttcgtcg gcacggacat ccaccaggtc gccgcacggc 86100
ggccggccgg ctgagccgcc gggggcggct acccgcaccg gtcgccccgg cccgccggct 86160
cgctgacgtc ggccagttcc ctcggaagct gctggcggcc cttcactccc agcttgcgga 86220
acacgttcgt gaggtgctgc tccacggtac tggccgtgac gaacagatgg tcggctatct 86280
ccctgttcgt acgccccacg gcggcgagtg cggacacccg ccgctccgac tccgtcagtg 86340
aggtgatgcg ctgtcccagc gttgcgtccc aggcaccgcc gaggtccgac ggtttcgcgc 86400
cgagcctcag cagcagcggc gccgcaccgc actgggtcgc caggtaccgt gccctgcgga 86460
tcaggccccg tgcccggttg tgctgtctga ccaggttgag cgcctcgccc aggtcactga 86520
ggacatgggc cagttcgtac tggtcattgc aggtgacgag gaggtcggct gcttcttcga 86580
gcaggtcgat ccgcttgggc agtggactgt aggccgcctg cacccgcagg gtcagggcgc 86640
gtgaccggga ccgcatcggc cgggacatct ggtcggatat gagccggagt ccttcggcgc 86700
ggtcggtgcc gagcatcagc agcgcctcgg cggcgtcgac ccgccagagc accaggcccg 86760
gcacgtcgac ggcccactgc cgcatccggt ccccgcactc cctgaacagt gcgtacgccg 86820
cccggtgccg cccggtcgcg aggtggtacc gcccccgggc ccagagcaga tgcagcccga 86880
agaggctctc cgaggtctcc tgcggcaacg gctcggagag ccaccggtcg gcccgttcga 86940
tatcgccgag tcggatcgcc gcaaccacgg tgctgctcag cggcagcgtg gccgccattc 87000
cccaggtggg caccagcccc tggccgaggg ccgcctcgcc gtaggcgacg gcggtggtca 87060
ggtcgccgcg gcgcagggcg gtctcggcgc cgaacccggc gtagatcgcc tcgtcggccg 87120
gggtgcgagt ctccttgtca ccggccagtc tgtcgaccca gaactggacg gcctcggtgt 87180
tctcggcgta gagcacggcc agcagcgcca tcatggccgt ggtccggtcc gccgtggcgt 87240
ctgtgtactg gaggacccgc tcggcatggg cgtccgccag ctccggccgg cctcgcagcg 87300
cggcgacgac ggccttgtct gcgaccgcgc gctgccgggc cgggccacgg agggcggcga 87360
gcccgcccgc ggcgaagaag tcggccctgc gcgaaggatc cgatctgccg ggatggacca 87420
gcgcgaggga taactcccct acgagcagca gcgcacggct ctggtcgtcc cctgccgcgg 87480
ggtgctgggt cgccagcact tcggccgcct cccccggccg cccgcccatc gccagccagt 87540
cggcgaggga cacggcatgc tcgccggaga gcagtcccgc gcgcgccgcg gtgagcagct 87600
ccggcagatg tcggccggcc ctcatcggat cgcagatgcg ttcgacctcg gcggccccga 87660
tgcgcagcgc ggcccgtatg acggggtcgt cgcaggcgcg gtgggcgagc tccagatatc 87720
cgaccgcatc ctccagttcg ccgcgcagaa gatgctcccg cgcggcctcg gtgaacagtt 87780
cgaccgcgtc cgcgccgtgc acccggccgg tgcctatctg gtgacgggcg agcacattgc 87840
cggccacgcc gtggtcccgc agcagttcca gtgcggactc gtgcaggttc cggcggtcga 87900
gggccgacag gtcgtcgagg acgatggacc gggcctccgg gtgcggaaac cgtccgtcct 87960
gcagcagccg tccgtcctgc agctgttcgc agacctgctc gaaggcttcc gtgttgaggc 88020
cggtcatccg ctggacgagt acgggttcgg cgctcgcgcc gagtaccgcg gccgcccggg 88080
cgatgtgcaa tgccgtcggg ccgcaccggt agagggagcc caggtaggcg agccggtacg 88140
ccctgcccgc cacggcctcc gggcgccccg tggcccgcgc ctcccggatg tcgttgatca 88200
ggccgtgccc gaggagcagg ttgcctccgg tcgcccggaa cgtctcggca aggacgtcgt 88260
cgtgggtgtc ccggccgagg tggcggcgga cgagttcggc gctctccgtc tcgttgaggg 88320
gccgcagcgc tatctcctgg taggagcgga ggctcagcag ttccgcctgg aatcgggagt 88380
cggccggtgt cgggcggcgg agctcggtca gcacgatgga gatacgggcc gggccgatcc 88440
ggcgcgcgag gtgcagcaga cagagcagcg atgcgccgtc ggcatggtgc acgtcgtcga 88500
cgcctatcag aacgggccgg tccgcggcga gcgccagcag ggtccgggtg aactcggccc 88560
gcagccggtt gtcggtgccg atcggcgggc cctcgcacga ggccgtgagc cgggcgagac 88620
ccggcgcccg ggcggccggc tcgggatggt cgaagagctg gccgagcatc ccgtagggca 88680
gggcacgctc ctccatggag cacacggcgc gaagggtgac gaagccggtc ttggccgctc 88740
cggcctccag cagtgccgtc ttgccgctgg cgatcggccc ggtgatggtg acgacggcac 88800
cccgtccgct ttccgcgccg gagagtgccc ggtggagacg gctcagctcg tcgtcacgag 88860
cgatcagttc ataaggggct gctcgcactt ccggaaccac ctcgcggccg tcgtctccat 88920
gggttctgcg ccgttcatct actggtaaat gcagctatga acggcgttga ttaacagcat 88980
gatccggctc ctcggacacg tgtcctcccg gtgtcacgag ccttacgccc cgcgccaccg 89040
tctcggccac ttgttcctgg tgctcgacca gatagaaatg cccacccgag aagacctcca 89100
cggtcgtcgg cgcggtggtg tgcccggccc aggcgcgggc ctgctccacc gtggtcttgg 89160
ggtcgctgtc gccgatacat acggtgatcg gcgtgtccag cggcggcccg ctgcgccagc 89220
ggtacgtctc cgccgcgacg tagtccgcac gcagcggagg caggatcagc gcacgcagtt 89280
cgtcgtcggc catcacatcg gcgttcgtcc cgccgagagc gcccaccgct gccagcaagt 89340
cgtcgtccga cgtcagacgg acggtgtcgg tgagtggatg cgacggcgca cgtacgcccg 89400
agacgatcag gtgcgccacc gggatccgct gggccagttc gaacgcgagc gtggcgccca 89460
tactgtgtcc gaacagcacc aacggccggt cgagacccgg cttcagaacc tccgcgacga 89520
gcccggcgag ggtacgcagg tcccgcagcg gctcctcgtc acggcggtcc tggcggccgg 89580
ggtactgcac ggcatacacg tcggccaccg gggcgagcgc gcgggcgatc ggaaggtaga 89640
aggtcgccga acctccggag tgcggcagca gcaccacccg tacggaagct tccggcgccg 89700
ggaagaactg ccgcagccac agctcctggt tcatggcgca catccggtcc gggccccggg 89760
caccgtgggg acgccgtgcg aggcacaccc ggcatgcccg tgagccgggt caggtgtggg 89820
cgtcaccacg ccgccgaccc gccaggtcgt ccggttttcc ccgtcggagg ccggaaagac 89880
gaacggagga agtggctcga acagatgatc ccgcagcggt acccattcgg tcgtatccat 89940
ctcgccgggg agtctcaccg ctctccgacg gcattgaagc acgcgcatgc cggcctccag 90000
tccaaagatg gcaaatcgac actaacgatg ctggtgacgg acgtgacacc cctgaccggg 90060
cgcatcaccc cccagcaccg gggctggggc tacttgacaa cattcaccca acatcactcg 90120
ccgatatttc gaccaaatga cggcacttga gccgtccggt gatggaattc tgaatgtttc 90180
gacgtttttc tgcggtcacc cggggcaacc caattcagct gccggccggc ggagggcatg 90240
agggcggggc acccggacgt ctccggccgc atccgggccg acggccaccg gagcggcgcg 90300
ccggctgtcg acgggcgcat cggcatctgc gtttcctgat ccgtccggcc acgttgacga 90360
gttttcccgc cgggcggcgg cgaggccaat acatcatgct gatggtgccc atcagcaggg 90420
gtgatgcggg tccggtgatc cttgggaacg tcctgccttc cccggtggaa cgccgcgcga 90480
cggcgcgtgc cgccgccgac aatgtccacg cggcacttca acgtcaagac ccttcaccat 90540
cctgcccggt acccgccccg gtgcgccggg gagggcgtcg tccgcccccg ggaagcgtcc 90600
cgtaccggcg gcgggccccg gtccggacct ggccggttgc tagcctcccg gccatggagt 90660
tacgcaccct ggagtacttc gtcgccgttg ccgaggaacg gtccttcacc agggcggccg 90720
cgcgctgcca tgtcgtccag cccgcgatca gccagcggat ccgggccctg gagaaggagc 90780
tgggcgagcc cctcttcgaa cggctgcccc ggcaggtggt gctcacctcc ggcggcgccg 90840
cgctgctgcc gcacgcgcgg gcctgtctgg cggcggcagc cgcggcctcc ctggagttcg 90900
ccgaccggtc cggcctcctc agcggcacgc tggtgctggg gaccgccggc ggcctggagg 90960
gcacctccgt accccggctg ctcggtgagt accaccgccg ctatccggga gtgcaggtac 91020
gtctcaccgg ggcgcccagc cccgtgctga tggcgcaggc ccgcagcggg gagatcgacg 91080
ccgcggtgat cgcggaacct ccggggggcc tgccgcacgg cctcggttca cggtgcctcc 91140
tggaggaccg cttcgtcgcg gtgctgcccg ccggaacccg ggacccggac catcccatga 91200
ccctcgccga ggcggcccgc tgccccctca tcggctacgg ctccggcagc ggagcgcacg 91260
ccttcgtccg ggacgccttc gcggcacagg gcctgcaact ggacatcgcc tatgcgaccg 91320
ccgacatcgc cctccaggtg acgctggtgg ccgaggggat cggcatcgcc ctgacctcgt 91380
acacgaaccc gctgctccgg ctggaccaac ggatcgtcgt ggtaccgctg gagcccgcga 91440
tccggctgcg gaaggtgctc gcctggcggc tcgggaaccg tccggggcca ccgttacggg 91500
ccttcctcga cctgctgacg gagctgcccc acaccacgca tccgaccagc gcgaccgcag 91560
aggccccgca ggaccctcaa cccgccccac aggactgaga atcccccgct ccctcgctga 91620
gcgcataggc gatatgggcc tcgtcggctg cggtccagtc gcccatcgcc gcggtggccg 91680
gcaggtcccc gaggccgccg aagaaggcca tggccgggac gatcaccgca cccgcttccc 91740
gggcccggtc ccggtagtgg gcgaaggtgt cgagcggccc cggccgctcc ggcgtgcggg 91800
tggttcgggg gctgtggtgc atggaagcgc tgttgcggtg atagctggtc gttggcggca 91860
atcccttatg ggtacgggtg tctcccgtgc cggacagcag gaggacctcg atggcggctt 91920
cccggtgcgt ttcgcgacgg gtgctggcgg tggtgtgcgg gacggcggcg ctgtcgtcgc 91980
tgatgctgcc gtccgggcag gcggccgggc agcgggccga gccgcggtac gtggtgttcc 92040
agggcggtgg gacgtacaac tggaccagac cggccggggt cgagaacgta tccgtctatt 92100
tgtggggcgc gagcggcgga ggcggtgggg gcgccggggg cgggggcggc ggccggggag 92160
acgaccaggc gacggtgatc ggccccaaca acgcacggta ccgcggcggc ggcggaggcg 92220
gtgccggtgg tgcgggcggc ggaggcgggg cgggagactt cgtcgagtgc cacctcggca 92280
gattccagct cctggtggtg gagcccaccc tgcgggtggt agtgggccgg ggcggaaccg 92340
gcggaaccgc cggcccgggc ggcagcggcg agaccacggc agggctgctg ttcgacaacc 92400
cggcgacacc gggtaccggc ggggacggcg gaggggacgg cgggacctcg cggctcatcg 92460
ccacgaccac cctgtccggg aggaacgaaa ccgacttgtc ccgagcgtcg ggaggcaccg 92520
gcggcggcgg aacccgcggc gggggcggcg ggctggacgg gatcccgtcg tatctcgaac 92580
ccggcggaga gggccgggcc ggtgcgggcg gggcgggtgg cggcgcgggg agtgcggcgg 92640
cggacacctt ctgccagacc cgcgaccgga ccgtcacctt cggcaccggt ggtacggacg 92700
gcacctccgg cgggtccgga gcacagggcg cgctcccggc gggcggcgcg ggcggcggtc 92760
cgggtaccgg aggccgtgga ggcgccgcac ccgccgtcac ccaggtgacc ctccccgacg 92820
gcaccgtctt cccggtgccc gccggtgtcc tcagcggcgg cggtacgggc gggaacggcg 92880
gtacgggcgg ccggggcggc gacggcagct acaaaaccgg ccagggcggc ggtgtggtcc 92940
gcgcacagaa cgggaacccc ggcggccgcg gcttctacgg cggcgacgga tcccaggggc 93000
tggtcgtcat cgcctggtaa ccccgaacaa ctactccggg ccggcaccag ggcagcaatc 93060
gggcctgatg acacagcagc cggccggtcc gaacagcaac ctgcacagct cacagacgat 93120
cggggccccg ggggccgtcg tggcgcaggc cgccgcatgg tgcgccggga acgggaacgg 93180
agctgccgcg gcgctcccca cggcacccgg attcagaacc acggccgccg ccactgccgc 93240
catgacagcg gcaagcctct tgcccgtcgt catcactggt ctccttctgc tggtaccggc 93300
attcccctgc ctgcgttcct gcgcgaagtg gccgcggccc ggggggcggg tacggcagtg 93360
accgcgccga agcggacacg gccgtcgcgg acactccgtc cgcccccggc cgggaccgca 93420
cgccggaagc acttggcatg gacaccatca tcgggcgaag aactcgaaaa ggaccatccc 93480
tcacaagagg gacagctgaa cgggtgcccg ccggaggaag ccccctcctc ggtggcactc 93540
accggcctcc accccggata ccccgctcaa ggtggcggaa agtgcacacg ggattacgtt 93600
gatgggtgat cccctcttcc accctggggc cggccccggg ttcccgcgga aaggcctgcg 93660
ccatgcttct tcctcgtgcc ttgtccagtc ccgtccggct cacgcggacc ggacgcgggc 93720
agctgctccg tccggtcggt gcgagtgcgg tgctgatgct cggggcgggg gtgctgtggc 93780
ccccggaggc ggctgcccag cctcagcccg gctgcgtggc atcgggggcg acgaccaccc 93840
tctgcacggg ctacaccagc accacgtaca ccgtccccga caacgccact tcggtgtcct 93900
tcaccctggt cggggcaggg ggtggcgggg gcggtggcac cacgactctg ggcggcgcct 93960
cgggcgaggg ggcgggcgcg ggcggaacgc tgcggtgcac ggtcaccggc ctcgcgggcc 94020
ggacgctgaa cgtcaccgcc gcgggtccgg gccaccccgg ctaccgcggc cccggcggac 94080
ctgcgggccc cggcggaggc ggggacgacg tcggcgcgaa cggcttcgga ggaagtagcg 94140
gcgcccgtaa cggaggcggc ggcggtggag ggggcggagg ggcaagcaat gtccgtctcg 94200
ggacctacgg aaccgagttc accgccgtcg cggccggcgg aggcggcgga gcaggtatca 94260
acaggctccc gttcttcgga ctcagcggat ccgggggttc cgcccccgtg gtggcgtcct 94320
cggcgctggg cctgtcagcc ctcggcggga ataccctcct cgacttcgca acctccgacc 94380
cgcctgccgg gggagccgcg gactgcggcg cgtcgggcgc cttcgccgtc acctccaaaa 94440
cctccaccac gggcggcgac cccgacggcc tcaccggagg aaccgcgagc ggcgtacccg 94500
cctcctgcgg cacggcgaac ggccgcggcg gcaacggcgg ctcccccacc gatccgcacg 94560
gaaccaccgg cgaacccggc tgcgtcgtca tcacctacag caccacctga cccccggcga 94620
tgagaggtac cggcgctgcc gccttcggcc ctccggggaa caggaaggct gagcgccgcc 94680
cgcccgcaac ctcaacctca atctcaaccg gcatcacacc gaggtcacca ggcgatcacc 94740
acgtggccgt cgccgccctt accgccgtta ctgccggcct ggctgcccac cccgttcgtg 94800
tacaggaacc tctccgtcgc ccccttgcca cccgcgccgc cgttacctcc gttacctccg 94860
ctgccgccac cttgcccgac ggaagccgga ggagtgtagg tccggccgtc gggcagcgta 94920
acggtggtga cgacgaggcc tgctcctgca ccacctgccc ctccggtccc cccgttgccg 94980
ccgatacccc ggtccggtga atacaggacc gggcgggtgc cgttgatgcc cggggtacca 95040
ccggctccgc tgctaccgcc gactccgttg gtgaccggtt ccgtctcctc gccctcgcac 95100
agagcggtgg ttgacccacc cccggccggg ccaccggcgc cgcccggccg gccctcgctg 95160
ttgaaggccc cttcaccgcc gagaccgccc cggccggatt ccccgctgag cacccccgcc 95220
gccgggtccc cgccgacgaa gaggccggtc ggtgcggcgc ctacgccgtc cgacccgcca 95280
ccgccggtcc cgcccgggac cgggatcagc agcagggcgt cgtgcccgcc ctgcgccgcg 95340
ccaccgcctg aaccgccttc acggccgggg gcgacccgca ccgacagcga ctcaccggct 95400
agctgggcgg cggtgaaggt acacgcgacg aagcttccga cacctccgcc gccgcctccg 95460
ccgcctccac cacccccgcc gccaccgggt ccgttccgga caccaggagg agcaccgggg 95520
ggattgccgg tggtggcacc acccctggct ccgcctccgc cgccggctcc gccaccgcct 95580
ccgccactgg cgccccacag atacacggtg aactcctcca cccccacggg cacgctccac 95640
tgctgagggc cgtcagccgg agtgaatact cggtacccag gctcatccac cgcccgcccc 95700
ggcatgtccg atgcggcgta ccccaccccc gcaggtgtcg ccacccacat cacactccct 95760
gcgagcgtcg ccgtcatcac gcatcgccgc acacgagatc ctcgcaccgc atcctcctca 95820
ggaacccctc cagtgacagt ggtccctctg tcccctggcc gcttcacggc cacacgcgca 95880
ggcagcgcct gtcccccatt cgtcttcgac gaagaggcca tctgcatccg gcgtccaacg 95940
gaaaaggggc acccgagcgg cggacggggg gaattccggg cggtgatcac gggtgctcgg 96000
tagggtcggt ggtcttggac ggtgacggac aggagcgtgc cgatgcagtc tggcgagcag 96060
tcttcccggt cgggttcgcg ggtcgatccg tggcgcggac ggtacgcggc acgggcggcc 96120
gggatggtcg cctccgaggt ccgggccctg ttcgccgtgg catcgcggcc ggaaatcgta 96180
tcgctggccg ggggcatgcc gaacgtgtcc gcgctgccgc tggacgccat cggcacgctc 96240
atggccgaac tggtggcgga acggggcgcg gtggcgctcc agtacggctc cgcgcagggg 96300
gaccctgggc tgcgggagac gatctgccgg gtgatggccg ccgagggcat cgacgacgcg 96360
caccccgacg acgtgatggt caccgtcggc tcccagcagg ccctcgacct ggtgacccgg 96420
gtgttcgtcg accccggcga caccgtcgtc accgaagccc ccacctatgt gaccgccctc 96480
ggcgtcttcg ccgcctacca ggccaacgtc gtgcacgtcg ccatggacga ggacggcgtc 96540
gtccccgagg cgctgacgga gaccttcgcc cggctggagc gcgagggacg gcccgcgaag 96600
ctcttctaca ccgtgccgac gttccagaac ccggccggtg tcaccctttc cgcagcacgc 96660
cgcccccagg tggtggaggt ctgtcgccgg gccggggtcc tgcttctgga ggacaacccg 96720
tacggcctgc tccacctcga cggcgacgag ccgatgcggg ccctgcgcgc cgacgccccg 96780
gacgacgtga tctatctcgg ctccttctcc aaaaccctcg cccccggact ccgggtcggc 96840
tgggcgctcg ccccggcggc cgtacgggag aagctggtgc tcgcggccga gagtgcgatg 96900
ctctcgcact ccgtcttcaa ccagctcgcc gtcgaccgct atctgcgcac ccagccctgg 96960
cccgagcaga tgaaggactt ccgggcgatg taccgggagc ggcgcgacac catgctcgac 97020
gcactggaga agtacatgcc cccgggggtt tcgtggaccc gcccggccgg cggcttcttc 97080
gtgtgggtca ccctccccga aggactggac tccaaggcga tgctccccag agcgatccag 97140
tcccgggtcg cgtacgtccc gggcaccggg ttctacgcgg acggcggcgg acgccaggcg 97200
atgcggctgt cgtactgcta cccgccaccc gagcggatcc gcgacggggt acggctgctc 97260
gcggacgtca tcggcgccga gctgcggctg cgggacgtct tcggcacctc cgcccccgcc 97320
accagcaccg ggcctcaggc acccggcccc gaccaggcat gaccaccgag aaagaacgag 97380
gaaccatgac cgatctgcgg gtggtcgtca tcgcgggcgg cctctccccc gagcgcgagg 97440
tctcccagaa gtccggcgcc cgggtcgccg acgccctgcg ccgcgccggg gtcggaaccg 97500
aactccgcga cgtcggaccg gatctgctgc ccgcgctcgc cgacgcccag ggtgctgtgg 97560
tcttcccggt gctgcacggg gtggccggcg aggacggcac catcaaggag atcctcgaac 97620
tcgccggggt gccgtatgtc ggcgcccgtc ccggagcctg ccgcgccgcg ttcgacaagg 97680
cggtggcgaa ggagacgttc gtacgcgccg gactgtccac cggtg 97725
<210> 2
<211> 427
<212> PRT
<213> Streptomyces sp. GT1005
<400> 2
Val Ala Phe Leu Phe Pro Gly Gln Gly Ser Tyr Val Pro Gly Val Phe
1 5 10 15
Ala Gly Leu Gly Ala Asp Ala Gly Arg Val Ala Thr Leu Val Ala Glu
20 25 30
Ile Asp Ala Ala Val Glu Glu Phe Arg Leu Lys Pro Val Arg Pro Leu
35 40 45
Leu Phe Ser Pro Asp Ala Pro Ala Leu Ala Glu Leu Leu Glu Ser Asp
50 55 60
His Glu Arg Leu Asp Val Ala Ile Leu Ala Thr Ser Ile Ala Leu Ala
65 70 75 80
Glu Leu Leu Glu Ser Arg His Gly Met Ser Pro Asp His Val Ala Gly
85 90 95
His Ser Leu Gly Glu Phe Gly Ala Leu Ala Val Ala Gly Val Phe Thr
100 105 110
Pro Gly Asp Ala Ala Arg Ala Val Cys Glu Arg His Ala Thr Leu Arg
115 120 125
Lys Ala Pro Pro Pro Thr Gly Gly Met Leu Ala Val Lys Ala Asp Ala
130 135 140
Ala Arg Ala Gly Glu Leu Ile Ala Ala Ala Arg Ala Gly Thr Ser Ala
145 150 155 160
Val Ser Ala Leu Asn Ser Pro Ser Gln Thr Val Ile Ser Gly Ala Glu
165 170 175
Ala Asp Leu Val Lys Val Gln Gln Leu Ala Arg Glu Glu Gly Ile Arg
180 185 190
Thr Ser Arg Leu His Val Pro Gly Pro Phe His Val Pro Gln Leu Ala
195 200 205
Asp Ala Ser Ala Leu Tyr Ala Thr Thr Met Arg Thr Ile Arg Ile Ser
210 215 220
Ala Pro Arg Glu Arg Phe Phe Tyr Ser His Gly Leu Gly Arg Phe Leu
225 230 235 240
Thr Ala Gln Asp Asp Val Val Asp Leu Met Val Asn Asp Met Thr Arg
245 250 255
Pro Val Arg Phe His Asp Ser Val Arg Ala Leu Asn Ala Glu Gly Val
260 265 270
Thr Thr Tyr Val Glu Cys Gly Ala Leu Asp Val Leu Thr Arg Ile Val
275 280 285
Ser Gly Ser Leu Pro Arg Ala Val Thr Leu Ala Pro Leu Arg Glu Ala
290 295 300
Thr Thr Thr Pro Asp Leu Ser Ala Arg Leu Arg Pro Ala Gly Thr Pro
305 310 315 320
Ala Val Asn Gly Val Ala Ala Pro Ala Gly Pro Ala Pro Ala Ala Glu
325 330 335
Val Asp Pro Glu Val Leu Ala Gly Val Arg Ala Val Cys Ala Glu Val
340 345 350
Leu Glu Tyr Pro Leu Glu Val Ile Thr Asp Asp Ala Asp Phe Gln Ala
355 360 365
Asp Leu Gly Val Asp Ser Leu Ala Met Thr Glu Leu Gln Ala His Ala
370 375 380
Leu Gln Arg Phe Gly Leu Lys Glu Thr Leu Gln Asp Ala Asp Thr Gly
385 390 395 400
Thr Tyr Gly Thr Val Ser Gly Leu Ala Ala Tyr Ile Thr Gly Leu Leu
405 410 415
Ser Glu Gly Thr Gly Ser Val Ser Gly Arg Arg
420 425
<210> 3
<211> 1284
<212> DNA
<213> Streptomyces sp. GT1005
<400> 3
gtggcgttcc tcttccccgg ccaagggtcg tacgtaccgg gcgtcttcgc cggtctgggt 60
gccgatgccg gccgggtggc gaccctcgtc gcggagatcg acgcggccgt cgaggagttc 120
cggctgaagc cggtccggcc gcttctgttc tccccggacg ctccggcgct ggcggagctg 180
ctcgaatccg atcacgagcg gctcgacgtg gccatcctgg caacctccat cgccctggcg 240
gagcttctgg agtcacggca cgggatgagt cccgaccatg tcgccgggca cagtctcggg 300
gagttcggag ccctcgccgt cgccggtgtc ttcaccccgg gcgacgcggc cagggcggtc 360
tgcgaacgcc acgccacgct gcgcaaggcg ccgccgccca cgggcgggat gctggcggtg 420
aaggcggacg cggcccgcgc cggggagctg atcgctgccg cgcgggccgg gacgtcggcc 480
gtatcggcgc tgaactcccc cagccagacg gtgatcagcg gcgcggaagc ggatctggtg 540
aaggtgcagc agctggcacg ggaggaaggc atccgtacct cccggctgca tgtccccggc 600
cccttccacg tcccgcagct ggccgacgcg agcgccctgt acgcgacgac gatgcgcacc 660
atacggatat ccgcgccccg ggagcgcttc ttctactccc acggtctggg ccgcttcctg 720
acggcgcagg acgatgtcgt cgacctgatg gtgaacgaca tgacccgtcc ggtgcggttc 780
cacgactccg tacgcgcgct gaacgcggag ggcgtcacga cctatgtgga gtgcggtgcg 840
ctggacgtcc tcacccggat cgtgtccgga tcgctgcccc gcgccgtgac cctggcaccg 900
ctccgggagg ccacgacgac accggatctg tccgcccggc tgcggcccgc cggcaccccg 960
gccgtgaacg gcgtcgctgc gcccgcgggc ccggcgccgg ccgccgaggt cgacccggag 1020
gtgctcgcgg gggtacgtgc ggtgtgcgcc gaggtcctgg agtatccgct ggaggtgatc 1080
accgacgacg cggacttcca ggccgatctc ggtgtcgact ccctggcgat gaccgagctg 1140
caggcccacg cgctgcagcg gttcggtctg aaggagacgc tgcaggacgc ggatacggga 1200
acgtacggca cggtttccgg tctggccgcg tacatcacgg gcctgctgag tgagggcacc 1260
ggttccgttt ccgggcggcg gtga 1284
<210> 4
<211> 796
<212> PRT
<213> Streptomyces sp.GT1005
<400> 4
Val Ile Ser Arg Ala Pro Asp Gly Glu Gly Pro His Asp Asp Arg Val
1 5 10 15
Ala Val Val Gly Met Gly Val Ala Val Pro Gly Ala Cys Asp Pro Glu
20 25 30
Glu Leu Trp Lys Leu Leu Cys Gly Asp Arg Pro Val Phe Asp Glu Pro
35 40 45
Ser Asp Arg Phe Arg Leu Asp Ser Phe Trp Ser Ala Asp Pro Ala Ala
50 55 60
Glu Asp Arg Gly Tyr Val Arg Thr Ser Gly Phe Leu His Asp Phe Arg
65 70 75 80
Pro His Pro Ala Leu Ala Ala Glu Ile Ala Ala Gly Thr Leu Ser Ala
85 90 95
Ala Ala Gln Asn Pro Val Trp Leu Arg His Cys Leu Leu Gln Ala Arg
100 105 110
Asp Thr Val Thr Ala Arg Ser Thr Asp Arg Tyr Ala Tyr His Val Gly
115 120 125
Thr Ser Ala Leu Val Gly Gln Arg Thr Asp Glu Ala Val Leu Ala Glu
130 135 140
Cys Val Pro Arg Ala Val Ala Glu Arg Leu His Arg Asp Glu Pro Ala
145 150 155 160
Arg Met Ala Glu Ala Glu Ala Arg Leu Arg Ala Leu Leu Arg Ser His
165 170 175
His Gly Tyr Gly Ala Glu Glu Pro Arg Asp Thr Leu Pro Asp Arg Val
180 185 190
Val Arg Ala Ala Ala Ala Gly Leu Leu Pro Asp Asp Cys Glu Phe Ser
195 200 205
Val Val Asp Ala Ala Cys Ser Ser Ser Leu Tyr Ala Ile Gly Leu Gly
210 215 220
Val Ala Ser Leu Leu Ala Gly Ala Cys Asp Ile Ala Tyr Cys Gly Gly
225 230 235 240
Val Ser Gly Val Thr Pro Arg Tyr Asn Val Thr Phe Ser Lys Leu His
245 250 255
Gly Leu Ser Pro Ser Gly Asp Val Arg Ala Phe Asp Asp Asp Ala Asp
260 265 270
Gly Thr Leu Phe Ser Asp Gly Ala Gly Val Val Ala Leu Lys Arg Leu
275 280 285
Asp Arg Ala Val Glu Asp Gly Asp Pro Val Phe Gly Val Leu Val Gly
290 295 300
Phe Gly Gly Ser Ser Asp Gly Arg Gly Thr Ala Ile Tyr Ala Pro Asn
305 310 315 320
Pro Val Gly Gln Arg Arg Cys Leu Asp Arg Ala Arg Gln Ala Ser Gly
325 330 335
Leu Thr Ala Asp Asp Val Asp Trp Val Ile Ala His Gly Thr Gly Thr
340 345 350
Ala Val Gly Asp Ala Val Glu Leu Arg Thr Leu Ala Ala Ala Thr Asp
355 360 365
Pro Gly Ser Val Trp Cys Gly Ser Asn Lys Ser Leu Leu Gly His Thr
370 375 380
Gly Trp Ser Ser Gly Val Val Ser Val Val Gln Ala Leu Thr Ala Leu
385 390 395 400
Arg Gln Gly Thr Ile Pro Ala Gln Arg Arg Phe Thr Gly Pro Gly Leu
405 410 415
Thr Ala Gln Thr Gly Asp Arg Val Arg Ile Pro Ser Ala Asp Val Pro
420 425 430
Trp His Ala Gly Gly Arg Arg Ser Arg Thr Ala Gly Val Ser Ala Phe
435 440 445
Gly Phe Gly Gly Thr Asn Ala His Leu Leu Ile Thr Asp Arg Glu Pro
450 455 460
Val Arg Thr Gly Pro Arg Pro Ala Arg Thr Gly Pro Asp Pro Val Val
465 470 475 480
Val Leu Ala Trp Thr Ala His Leu Pro Gly Asp Pro Gly Pro Glu Ala
485 490 495
Thr Glu Arg Leu Leu Arg Glu Gly Arg Ile Pro Gly Pro Arg Thr Phe
500 505 510
Gly Pro Arg Tyr Pro Ala Pro Pro Phe Pro Asp Val Arg Leu Pro Pro
515 520 525
Pro Thr Val Arg Ser Thr Asp Ala Gly Gln Leu Met Ala Leu Arg Val
530 535 540
Ala Gly Leu Phe Ala Ala Glu His Gly Glu Leu Trp Ala Pro Val Arg
545 550 555 560
Ala Thr Thr Gly Val Phe Ala Ala Ala Thr Gly Pro Pro Pro Ser Ser
565 570 575
Met Asp His Leu Val Arg Cys His Ala Ala Asp Val His Arg Ile Leu
580 585 590
Asp Glu Pro Asp Arg Thr Ala Phe Thr Glu Trp Leu Ala Asp Leu Arg
595 600 605
Ala Thr Thr Pro Ala Thr Thr Lys Asp Thr Leu Pro Gly Leu Leu Pro
610 615 620
Asn Ile Ile Pro Ala Arg Ile Ala Asn Arg Tyr Asp Leu Gly Gly Pro
625 630 635 640
Thr Met Leu Val Asp Thr Gly Thr Thr Ser Gly Leu Thr Ala Val His
645 650 655
Thr Ala Val Arg Gln Leu Ala Ala Gly Ala Val Asp Met Ala Leu Val
660 665 670
Leu Gly Val Ser Ala Thr Gly Arg Pro Glu Phe Ala Arg Phe Met Gly
675 680 685
Val Ala Ala Glu Arg Ile Ala Glu Gly Ala Phe Leu Leu Ala Leu Ser
690 695 700
Arg Glu Ser Val Ala Leu Ala His Gly Leu Thr Pro Leu Val Arg Leu
705 710 715 720
Arg Thr Asp Trp Thr Gly Ser Pro Gln Ala Ser Ala Asp Ala Val Pro
725 730 735
Gly Gly Pro Gly Ala Ala Glu Asp Thr Phe Leu Gly Ala Asp Gly Val
740 745 750
Leu Ala Val Ile Arg Ala Leu His Ser Thr Ala Ser Gly Val Thr Val
755 760 765
Gly Pro Ala Asp Gly Glu Pro Gly Pro Val Ile Thr Leu Ser Pro Ala
770 775 780
Asp Gly Ser Pro Leu Arg Gln Thr Arg Thr Ser Arg
785 790 795
<210> 5
<211> 2391
<212> DNA
<213> Streptomyces sp. GT1005
<400> 5
gtgatctccc gtgctccgga cggggagggg ccgcacgacg acagggtcgc cgtcgtcggg 60
atgggtgtcg ccgtgccggg cgcctgcgac ccggaggagc tgtggaagct gctgtgcggt 120
gacagacccg tgttcgatga gccgtcggac cgcttccggc tcgattcctt ctggtccgcg 180
gatccggccg ccgaggaccg cggctatgtc cgcacttcgg gttttctgca cgacttccgt 240
ccgcaccccg cactggccgc ggagatcgcg gccggaacgc tctcggccgc cgcgcagaac 300
ccggtctggc tgcggcactg cctgctgcag gcgcgggaca ccgtcaccgc ccgcagcacc 360
gaccgatacg cctaccacgt cgggaccagc gccctggtcg gccagcgcac cgacgaggcg 420
gtgctggccg agtgcgttcc ccgggccgtc gccgagcggc tgcaccgcga cgagcccgcc 480
cggatggccg aggccgaggc acggctgcgc gccctgctga gaagccacca cgggtacggc 540
gccgaagagc cgcgggacac actgcccgac cgggtcgtac gggccgcggc ggccggactg 600
ttacccgacg actgcgagtt ctccgtggtc gacgcggcct gctcgtcctc gctgtacgcg 660
atcggtctgg gtgtcgcgag cctgctggcg ggcgcctgcg atatcgccta ctgcggcggg 720
gtgtcgggag tgacgccgcg ttacaacgtc acgttctcca aactgcacgg gctgagcccc 780
agcggcgacg tccgcgcgtt cgacgacgac gccgacggaa cgctgttctc ggacggagcg 840
ggcgttgtcg cgctgaagcg cctggaccgg gccgtcgagg acggggaccc ggtgttcggc 900
gtcctcgtgg gattcggcgg gtcgtcggac ggccggggaa cggcgatcta cgcccccaac 960
cccgtcggtc agcgccgctg cctggaccgc gcccggcagg catcgggtct cacggcggac 1020
gatgtcgact gggtcatcgc gcacgggacg ggcacggccg tcggtgacgc ggtcgagctg 1080
cggaccctcg ccgccgccac cgatccgggc agcgtctggt gcggatccaa caagtccctg 1140
ctcggtcata ccgggtggag ctccggagtg gtctcggtcg tccaggccct cacggcgctg 1200
cggcagggca cgataccggc acagcgacgc ttcaccggtc ccgggctcac cgcgcagacc 1260
ggcgaccggg tacgcatacc ttcggcggac gttccctggc atgcgggcgg ccggcgttcc 1320
aggaccgcag gcgtctccgc cttcggcttc ggcggcacca acgcccatct gctgatcacc 1380
gaccgagagc ccgtgcggac gggcccgcgc cccgcccgca ccgggcccga tccggtggtc 1440
gtcctcgcct ggaccgcgca cctgcccggc gaccccggcc ccgaggcgac ggagcggctg 1500
ctgcgcgaag gccgcatccc cgggccgcgt accttcggcc cccgctatcc ggcgcccccg 1560
tttccggacg tccgtctccc tccgcccacc gtacggtcca cggacgcggg ccagctcatg 1620
gccctgcggg tggcgggcct gttcgccgcc gaacacggtg agctgtgggc gccggtacgg 1680
gcgaccaccg gggtcttcgc ggccgccacc ggtccgccgc cgtcctccat ggatcatctg 1740
gtgcgctgtc atgccgccga cgtacaccgc attctcgacg aacccgaccg gacggcgttc 1800
accgaatggc tcgccgacct gcgggccacg accccggcga ccaccaagga cacgctgccg 1860
gggctgctgc ccaacatcat cccggcgcgt atcgccaacc gctacgacct gggcggcccc 1920
accatgctgg tcgacacggg caccaccagc gggctcaccg ccgtgcacac cgccgtccgc 1980
caactggcgg ccggtgccgt cgacatggcg ctcgtcctcg gtgtcagcgc gaccggccga 2040
cccgagttcg cccgcttcat gggcgtcgcg gccgagcgga tcgcggaggg ggcgttcctc 2100
ctcgcgctga gtcgcgagtc cgtcgccctc gcgcacggcc tgacccccct cgtccgcctc 2160
cgcacggact ggaccggcag ccctcaggcg tctgcggatg ccgtccccgg cgggcccggt 2220
gcggcggagg acaccttcct cggcgccgac ggcgtcctcg ccgtgatccg tgccctgcac 2280
tccaccgcgt ccggcgtcac cgtgggaccc gcggacggcg aaccgggccc ggtgatcacc 2340
ctctcccccg ccgacggctc acctcttcgg cagacaagga ccagccgatg a 2391
<210> 6
<211> 445
<212> PRT
<213> Streptomyces sp. GT1005
<400> 6
Met Thr His Val Arg Asp Ala Ala Ala Thr Asp Asp Pro Gln Ala Ile
1 5 10 15
Ala Ala Cys Glu Val Pro Ala Gly Tyr Arg Ala Ala Val Val Leu Ala
20 25 30
Ala Asp His Gln Ala Leu Ala Gly Ser Pro Val Glu Asp Arg Asp Pro
35 40 45
Arg Lys Thr Val Gln Val Gln Glu Val Pro Thr Pro Glu Pro Asp His
50 55 60
Gly Glu Val Leu Ile Ala Thr Met Ala Ser Ser Ile Asn Tyr Asn Thr
65 70 75 80
Val Trp Ser Ala Leu Phe Glu Pro Val Pro Thr Phe Arg Phe Leu Arg
85 90 95
Thr Leu Gly Arg Thr Ser Pro Glu Ala Ala Arg His Asp Gln Pro Tyr
100 105 110
His Val Leu Gly Ser Asp Leu Ser Gly Val Val Leu Arg Thr Gly Pro
115 120 125
Gly Val Arg Glu Trp Lys Pro Gly Asp Glu Val Val Ala His Cys Leu
130 135 140
Gln Pro Asp Leu Gln Thr Pro Gly Gly His Asp Asp Thr Leu Leu Asp
145 150 155 160
Pro Gly Gln Arg Val Trp Gly Tyr Glu Thr Asn Phe Gly Gly Leu Ala
165 170 175
Glu Leu Ser Leu Val Lys Ala Asn Gln Leu Met Pro Lys Pro Ala His
180 185 190
Leu Thr Trp Glu Glu Ala Ala Ser Leu Gly Val Ala Leu Ser Thr Ala
195 200 205
Tyr Arg Gln Leu Val Ser His His Gly Ala Ala Met Lys Gln Gly Glu
210 215 220
Arg Val Leu Val Trp Gly Ala Ala Gly Gly Val Gly Ala Tyr Ala Thr
225 230 235 240
Gln Leu Ala Leu Asn Gly Gly Ala Val Pro Ile Cys Val Val Ser Ser
245 250 255
Gln Ala Lys Ala Asp Leu Cys Arg Gln Met Gly Ala Glu Leu Val Ile
260 265 270
Asp Arg Ala Ala Glu Gly Phe Ser Phe Trp Glu Gly Arg Asp Arg Pro
275 280 285
Arg Leu Ser Glu Trp Ser Arg Phe Arg Gly Ala Val Arg Ser Leu Ala
290 295 300
Gly Asp Asp Pro Asp Ile Val Ile Glu His Pro Gly Arg Asp Thr Phe
305 310 315 320
Gly Val Ser Val Met Ile Ala Ala Arg Gly Gly Lys Val Val Thr Cys
325 330 335
Ala Ser Thr Thr Gly Tyr Gln His Thr Tyr Asp Asn Arg His Leu Trp
340 345 350
Met Arg Val Lys Arg Ile Ile Gly Ser His Met Ala Asn Tyr Arg Glu
355 360 365
Ala Trp Ala Ala Asn Glu Leu Val Ala Arg Gly Ser Ile His Pro Val
370 375 380
Leu Ser Arg Val Tyr Pro Leu Asp Ala Thr Gly Asp Ala Thr His Ala
385 390 395 400
Val Ala Asn Asn Ser His His Gly Lys Val Gly Val Leu Cys Leu Ala
405 410 415
Asp Arg Pro Gly Met Gly Val Arg Asp Pro Glu Leu Arg Ala Arg Lys
420 425 430
Leu Asp Ser Ile Asn Leu Phe Arg Lys Gly Gln Pro Arg
435 440 445
<210> 7
<211> 1338
<212> DNA
<213> Streptomyces sp. GT1005
<400> 7
atgacccacg ttcgcgacgc cgcggccacc gacgacccgc aggccatcgc cgcctgcgag 60
gtcccggccg gctaccgggc cgccgttgtc ctcgcggccg accaccaggc actcgccggg 120
agccccgtcg aagaccggga cccccgcaag acggtccagg tccaggaggt ccccaccccc 180
gaaccggacc acggcgaggt gctcatcgcc accatggcga gctccatcaa ctacaacacc 240
gtgtggtcgg cgctcttcga gcccgttccc accttccgct ttctgcgcac cctcggccgt 300
acctcaccgg aggcggcccg ccacgaccag ccgtaccacg tgctcggctc cgacctgtcc 360
ggagtggtgc tgcgcaccgg accgggtgta cgggagtgga agcccggcga cgaagtcgtc 420
gcgcactgtc tgcaaccgga cctgcagacg ccgggcgggc acgacgacac cctgctcgac 480
cccggccagc gggtctgggg ctacgagacg aacttcggcg gcctcgccga actctccctg 540
gtcaaggcga accagctgat gccgaagccc gcccatctca cctgggagga ggcggcctcc 600
ctgggggtgg cgctctccac ggcctaccgt cagctggtgt cccaccacgg ggcggcgatg 660
aagcagggcg agcgcgtcct ggtctggggt gccgccggtg gcgtcggcgc ctacgcgacc 720
cagctggccc tcaacggcgg cgccgttccg atctgtgtgg tgtcgtcgca ggccaaggcc 780
gacctgtgcc ggcagatggg cgcggagctc gtcatcgacc gtgctgcgga gggcttctcg 840
ttctgggagg ggcgggaccg cccgcggctg agcgagtgga gccgcttccg cggtgccgtc 900
cggtccctgg cgggtgacga cccggacatc gtcatcgagc accccggccg ggacaccttc 960
ggcgtcagcg tcatgatcgc cgcccggggc ggaaaggtgg tcacctgcgc atcgaccacc 1020
ggctaccagc acacctacga caaccgccat ctgtggatgc gcgtcaaacg catcatcggg 1080
tcacatatgg cgaactaccg ggaagcctgg gccgcgaacg aactcgtcgc acgcggcagc 1140
atccaccccg tgctctcccg ggtctacccc ctcgacgcca caggcgacgc cacgcacgcc 1200
gtcgccaaca acagccacca cggcaaggtg ggcgtgctct gcctcgccga ccgccccggc 1260
atgggagtgc gcgaccccga gctgcgggcc cggaaactcg acagcatcaa cctgttccgg 1320
aaggggcagc cccggtga 1338
<210> 8
<211> 386
<212> PRT
<213> Streptomyces sp. GT1005
<400> 8
Val Ser Glu Ser Glu Arg Leu Gly Ile Val Arg Asp Phe Val Ala Arg
1 5 10 15
Glu Ile Leu Gly Arg Glu Gly Ile Leu Asp Ser Leu Ala Asp Ala Pro
20 25 30
Leu Ala Leu Tyr Glu Arg Phe Ala Glu Thr Gly Leu Met Asn Trp Trp
35 40 45
Val Pro Lys Glu His Gly Gly Leu Gly Leu Gly Leu Glu Glu Ser Val
50 55 60
Arg Ile Val Ser Glu Leu Ala Tyr Gly Asp Ala Gly Val Ala Phe Thr
65 70 75 80
Leu Phe Leu Pro Val Leu Thr Thr Ser Met Ile Gly Trp Tyr Gly Ser
85 90 95
Glu Glu Leu Lys Glu Arg Phe Leu Gly Pro Leu Val Ala Arg Arg Gly
100 105 110
Phe Cys Ala Thr Leu Gly Ser Glu His Glu Ala Gly Ser Glu Leu Ala
115 120 125
Arg Ile Ser Thr Thr Val Arg Arg Asp Gly Asp Thr Leu Val Leu Asp
130 135 140
Gly Thr Lys Ala Phe Ser Thr Ser Thr Asp Phe Ala Arg Phe Leu Val
145 150 155 160
Val Ile Ala Arg Ser Ala Asp Asp Pro Ala Arg Tyr Thr Ala Val Thr
165 170 175
Val Pro Arg Asp Ala Pro Gly Leu Arg Val Asp Lys Arg Trp Asp Val
180 185 190
Ile Gly Met Arg Ala Ser Ala Thr Tyr Gln Val Ser Phe Ser Asp Cys
195 200 205
Arg Val Pro Gly Asp Asn Ala Leu Asn Gly Asn Gly Leu Arg Leu Leu
210 215 220
Glu Ile Gly Leu Asn Ala Ser Arg Ile Leu Ile Ala Ala Ser Ala Leu
225 230 235 240
Gly Val Ala Arg Arg Ile Arg Asp Val Cys Met Glu Tyr Gly Lys Thr
245 250 255
Lys Ser Leu Lys Gly Ala Pro Leu Val Lys Asp Gly Val Phe Ala Gly
260 265 270
Arg Leu Gly Gln Phe Glu Met Gln Ile Asp Val Met Ala Asn Gln Cys
275 280 285
Leu Ala Ala Ala Arg Ala Tyr Asp Ala Thr Ala Ala Arg Pro Asp Ala
290 295 300
Ala Arg Val Leu Leu Arg Gln Gly Ala Gln Lys Ser Ala Leu Thr Ala
305 310 315 320
Lys Met Phe Cys Gly Gln Thr Ala Trp Gln Ile Ala Ser Thr Ala Ser
325 330 335
Glu Met Phe Gly Gly Ile Gly Tyr Thr His Asp Met Val Ile Gly Lys
340 345 350
Leu Leu Arg Asp Val Arg His Ala Ser Ile Ile Glu Gly Gly Asp Asp
355 360 365
Val Leu Arg Asp Leu Val Tyr Gln Arg Phe Val Val Pro Thr Ala Lys
370 375 380
Arg Thr
385
<210> 9
<211> 1161
<212> DNA
<213> Streptomyces sp. GT1005
<400> 9
gtgagcgaat ccgaacgcct cggtatcgtc agggatttcg tcgcccggga gatcctgggc 60
cgcgaaggca tcctcgactc gctggcggac gcaccactgg ccctgtacga acgcttcgcc 120
gagacgggcc tgatgaactg gtgggtcccc aaggagcacg gcggtcttgg gctcggcctg 180
gaagagagtg tgcggatcgt ctccgaactc gcctacgggg acgccggggt ggcgttcacc 240
ctgtttctgc ccgtcctgac gaccagcatg atcggctggt acggcagcga ggagctcaag 300
gagagattcc tcggccctct cgtggcccgg cggggcttct gcgccacgct gggcagcgag 360
cacgaggccg gcagcgaact ggcccggatc tccaccacgg tccgccgtga cggcgacacg 420
ctggtactcg acggcaccaa ggccttctcc accagcaccg acttcgcccg gttcctcgtc 480
gtcatcgccc gttcggcgga cgacccggcc cggtacacgg cggtcaccgt accgcgggac 540
gcgccggggc tgcgggtcga caaacgctgg gacgtcatcg ggatgcgcgc ctccgcgacc 600
tatcaggtgt cgttctccga ctgccgggtg ccgggggaca acgcgctgaa cggcaatggg 660
ctgcggctgc tggagatcgg cctcaacgcc agcagaatcc tgatcgccgc atccgctctg 720
ggtgtcgccc gcaggatccg cgatgtgtgc atggagtacg ggaagacgaa gtcgctcaag 780
ggcgctccgc tcgtcaagga cggcgtgttc gccgggcggc tcggccagtt cgagatgcag 840
atcgacgtga tggcgaacca gtgcctggcg gccgcacggg cctacgacgc gaccgcggcc 900
cggcccgacg ccgccagggt gctgctgcgg cagggcgccc agaagtcggc actgaccgcg 960
aagatgttct gcgggcagac ggcctggcag atcgcgtcca ccgcgtcgga gatgttcggc 1020
ggcatcgggt acacgcacga catggtgatc gggaagctgc tgcgggatgt gcggcacgct 1080
tcgatcatcg agggcggcga cgacgtcctg cgcgatctcg tctaccagcg cttcgtcgtc 1140
cccaccgcga aacgtaccta g 1161
<210> 10
<211> 384
<212> PRT
<213> Streptomyces sp. GT1005
<400> 10
Met Pro Ser His His Trp Glu Thr Arg Ala Val His Ala Gly Arg Glu
1 5 10 15
Asp Leu Val Asp Leu Gly Leu His Val Pro Pro Ile Asp Leu Ser Thr
20 25 30
Thr Tyr Pro Ser Arg Asp Thr Val Ala Glu Ala Ala Arg Ile Asp Val
35 40 45
Phe Gly Ser Gly Ala Asp Asp Gly Gly Pro Pro Ile Tyr Gly Arg Ala
50 55 60
Gly Asn Pro Thr Val Ala Arg Phe Glu Ser Ala Leu Ala Glu Leu Glu
65 70 75 80
Gly Ala Glu Ala Ala Val Ala Phe Ala Ser Gly Met Ala Ala Leu Cys
85 90 95
Ala Cys Leu Leu Val Gln Val Ala Arg Gly Arg Pro His Ile Val Ala
100 105 110
Val Arg Pro Leu Tyr Gly Thr Ser Asp Tyr Leu Leu Asp Ser Gly Leu
115 120 125
Leu Gly Thr Ser Val Thr Trp Ala Gln Pro His Ser Ala Gly Asp Ala
130 135 140
Ile Arg Ser Asp Thr Gly Leu Val Ile Val Glu Ser Pro Ala Asn Pro
145 150 155 160
Thr Leu Thr Glu Thr Asp Ile Gln Ala Leu Ala Ala Ala Cys Ala Pro
165 170 175
Val Pro Val Leu Val Asp Asn Thr Phe Ala Thr Pro Ala Leu Gln Arg
180 185 190
Pro Leu Asn Arg Gly Ala Ala Ile Val Leu His Ser Ala Thr Lys Tyr
195 200 205
Leu Gly Gly His Gly Asp Val Met Gly Gly Val Val Ala Ser Asn Glu
210 215 220
Glu Phe Ala Arg Ala Leu Arg Arg Ile Arg Phe Ala Thr Gly Gly Ile
225 230 235 240
Leu His Pro Leu Ala Gly Tyr Gln Leu Leu Arg Gly Leu Ser Thr Leu
245 250 255
Ser Val Arg Met His His Ala Ser Ala Ser Ala Ala Glu Ile Ala Arg
260 265 270
Arg Leu Leu His His Pro Ala Val Thr Arg Val His Tyr Pro Gly Leu
275 280 285
Ser Gly Glu Pro Arg Pro Pro Lys Gln Met Ala Ala Gly Gly Ala Ile
290 295 300
Val Ser Phe Glu Val Asp Asp Pro His Ala Val Thr Gly Gly Val Arg
305 310 315 320
Leu Phe Thr Pro Ala Val Ser Leu Gly Ser Val Asp Ser Leu Ile Gln
325 330 335
His Pro Val Ser Leu Thr His His Ala Met Asp Pro Gly Ser Arg Glu
340 345 350
Gln Ala Gly Ile Ser Asp Arg Leu Leu Arg Ile Ser Val Gly Leu Glu
355 360 365
His Val Asp Asp Leu Trp Ala Asp Leu Thr Gln Ala Leu Thr Arg Asp
370 375 380
<210> 11
<211> 1155
<212> DNA
<213> Streptomyces sp. GT1005
<400> 11
atgccttcgc atcactggga aacccgggcg gtccatgccg gccgtgagga tcttgtcgat 60
ctcggactgc atgtcccgcc catagacctg tccaccacct acccctcccg cgacaccgtt 120
gccgaggcgg cgcggatcga cgtgttcggc tccggagccg acgacggcgg tccgccgatc 180
tacggccggg cagggaaccc caccgtcgca cggttcgagt ccgcgctggc cgaactggaa 240
ggggccgaag ccgcggtggc cttcgccagc ggtatggcag cgctctgcgc ctgccttctc 300
gtgcaggtcg cccggggacg gccgcatatc gtcgccgtcc gtcccctgta cggcaccagc 360
gactacctcc tggactcggg cctgctgggc acctcggtga cctgggcgca accccacagc 420
gccggcgatg ccatccgcag cgacacgggg ctggtgatcg tcgagtcacc cgccaacccc 480
acactgacgg agaccgacat ccaggcgctg gccgctgcat gcgctccggt tccggtactg 540
gtcgacaaca ccttcgcaac gcccgcgctc cagcgccccc tgaacagggg tgccgccatc 600
gttctgcaca gcgcgacgaa gtacctgggg ggccacggtg acgtcatggg cggtgtggtg 660
gcgtcgaacg aggagttcgc ccgtgccctg cggcggatcc ggttcgccac cggagggatc 720
ctgcaccccc tggctggcta ccagctcctc agaggactgt cgacgctctc ggtgcggatg 780
caccacgctt cggcctcggc tgccgagatc gcccgccggc tcctgcacca tccggcggtc 840
accagggtcc actacccggg gctgagcggt gaaccccggc cgccgaagca gatggccgca 900
ggcggggcaa tcgtgtcctt cgaggtcgac gatccgcacg cggtgaccgg cggcgtacgt 960
ctcttcaccc cggcggtcag cctcggcagc gtcgacagcc tcattcagca cccggtctcg 1020
ctcacccacc acgccatgga cccgggctca cgcgaacagg ccggtatctc cgaccgactg 1080
ctccggatct ccgtcggcct cgaacacgtc gacgatctgt gggccgacct cacccaggcc 1140
ctgacgcggg actga 1155
<210> 12
<211> 155
<212> PRT
<213> Streptomyces sp. GT1005
<400> 12
Met Lys Glu Lys Val Val Leu Asp Ser Ile Asp Gln Ala Ile Leu Arg
1 5 10 15
Glu Leu Gln Asn Asp Gly Arg Leu Pro Asn Lys Thr Leu Ala Arg Arg
20 25 30
Val Gly Val Ala Pro Ser Thr Cys Leu Ala Arg Thr Gln Arg Leu Met
35 40 45
Glu Ala Gly Val Ile Arg Gly Phe Gln Ala Gln Val Ser Ala Ala Ala
50 55 60
Ile Gly Arg Gln Val Gln Ala Val Leu Ala Val Gln Phe Ile Ala His
65 70 75 80
Ser Arg Pro Phe Val Asp Pro Phe Val Ala Trp Ala Arg Glu Arg Pro
85 90 95
Glu Thr Arg Ala Leu His His Val Thr Gly Ala Phe Asp Phe Leu Val
100 105 110
His Thr Ala Cys Arg Asp Thr Glu Asn Leu Gln Gln Leu Val Leu Glu
115 120 125
Phe Thr Ala Arg Arg Glu Val Gly Arg Val Glu Thr His Leu Val Phe
130 135 140
Gly Ser Trp Ser Gly Gly Pro Leu Thr Pro Gly
145 150 155
<210> 13
<211> 468
<212> DNA
<213> Streptomyces sp. GT1005
<400> 13
atgaaagaaa aggttgtcct ggattcgata gatcaggcaa ttctgcgtga gctgcagaat 60
gatggtcggc tgcccaacaa gacgctggcc cggagggtcg gcgtggcacc gtccacctgt 120
ctggcccgca cgcagaggct gatggaggca ggtgtgatca gaggtttcca ggctcaggtg 180
agtgccgcgg cgatcggccg gcaggtccag gccgtcctcg ccgtccagtt catcgcccat 240
tcacgtccct ttgtcgaccc gttcgtggca tgggccaggg agcggcccga gactcgtgcg 300
cttcaccatg tgaccggagc cttcgacttc ctcgtccaca cggcctgccg tgacaccgag 360
aacctccagc aactcgtcct ggagttcacc gcacgccgag aggtgggccg agtggagacc 420
cacctcgtat tcggatcctg gtcgggagga cccctgactc cgggctag 468
<210> 14
<211> 409
<212> PRT
<213> Streptomyces sp. GT1005
<400> 14
Val Asp Arg Glu Pro Val Phe Val Leu Asp Pro Arg Gly Gly Asp Arg
1 5 10 15
His Gly Glu Asp Ala Ala Leu Arg Ala Arg Gly Pro Leu Thr Arg Val
20 25 30
Asp Ala Leu Gly Val Glu Ala Trp Ser Val Thr Asp Pro Val Leu Leu
35 40 45
Arg Arg Leu Leu Leu Asp Ser Arg Val Ser Lys Asn Ala Arg Gln His
50 55 60
Trp Pro Ala Phe Pro Glu Glu Ile Val Gly Val Trp Pro Leu Ala Leu
65 70 75 80
Trp Val Ala Val Glu Asn Met Phe Thr Ala Tyr Gly Glu Glu His Arg
85 90 95
Arg Leu Arg Arg Thr Ile Gly Pro Ala Phe Ala Ala Arg Arg Ile Asn
100 105 110
Ala Leu Ala Pro Val Ile Glu Gln Leu Val Gly Glu Leu Leu Asp Glu
115 120 125
Leu Ala Ala Thr Pro Pro Gly Glu Pro Val Asp Leu Arg Glu His Phe
130 135 140
Ala Tyr Pro Leu Pro Ile Gly Val Val Gly Gln Leu Ala Gly Leu Pro
145 150 155 160
Glu Ser Val Arg Pro Arg Phe Arg Arg Thr Val Asp Val Ile Phe Ser
165 170 175
Thr Ser His Ser Pro Glu Glu Thr Thr Ala Ala Val Gln Asp Leu Tyr
180 185 190
Ala Leu Leu Ala Asp Leu Val Ala Ala Lys Arg Ala Glu Pro Gly Asp
195 200 205
Asp Leu Thr Ser Ala Leu Ile Ala Ala Arg Asp Thr Glu Gly Asp Gly
210 215 220
Glu Pro Leu Thr Glu Ala Glu Leu Val Asp Thr Leu Leu Leu Val Val
225 230 235 240
Asn Ala Gly Phe Glu Thr Thr Val Asn Leu Leu Asp Gln Ala Ile Thr
245 250 255
Ala Leu Leu Thr Asp Pro Gly Gln Leu Ala His Val Arg Ala Gly Arg
260 265 270
Ala Gly Trp Lys Asp Val Val Glu Glu Ser Leu Arg His Glu Ala Pro
275 280 285
Leu Ala His Leu Pro Met Arg Phe Ala Val Glu Asp Ile Pro Leu Pro
290 295 300
Glu His Gly Val Thr Ile Arg Gln Gly Asp Ala Val Leu Pro Ala Tyr
305 310 315 320
Ala Ala Ala Asn Arg His Pro Asp Leu His Gly Leu Thr Ala Asp Asp
325 330 335
Phe Asp Ala Thr Arg Ser Asp Lys Ser His Leu Ser Phe Gly His Gly
340 345 350
Met His Leu Cys Leu Gly Ala Ala Leu Gly Arg Leu Glu Ala Glu Ile
355 360 365
Ala Leu Arg Gly Leu Phe Glu Arg Phe Pro Arg Leu Ala Leu Ala Val
370 375 380
Pro Leu Asp Arg Leu Arg Pro Lys Pro Ser Phe Ile Ser Asn Gly His
385 390 395 400
Ser Glu Leu Pro Val Ile Ile Asp Pro
405
<210> 15
<211> 1230
<212> DNA
<213> Streptomyces sp. GT1005
<400> 15
gtggaccgag aacccgtttt cgtcctcgac ccgcgcggcg gcgatcgcca tggcgaggac 60
gccgccctcc gcgcccgcgg ccccctgacc cgagtcgacg ccctcggcgt ggaggcgtgg 120
tcggtcaccg acccggtgct gctccgtcgg ctgctgctgg actcgcgggt ctccaaaaac 180
gcccggcaac actggcccgc cttcccggag gagatcgtcg gagtctggcc gctcgccctc 240
tgggtcgccg tggagaacat gttcaccgcc tatggcgagg agcaccgacg gctgcggcgg 300
accatcgggc cggccttcgc cgcccgcagg atcaacgcgc tggcgccggt catcgagcag 360
ctcgtggggg agctgctgga cgagctcgcc gccaccccgc ccggagagcc ggtcgacctg 420
cgggagcact tcgcctatcc gctgcccatc ggggtcgtcg gccagctcgc cggcctcccc 480
gaatccgtcc ggccccggtt ccgccgtacc gtcgacgtga tcttctccac cagccacagc 540
cccgaggaga cgaccgccgc ggtccaggat ctgtacgcgc tcctcgccga cctcgtggcc 600
gccaagcgcg ccgagccggg agacgacctc acgtcggcgc tcatcgccgc cagggatacg 660
gaaggcgacg gagagcccct gacggaggcc gaactcgtcg acaccctgct gctggtggtc 720
aacgccggtt tcgaaaccac cgtcaacctc ctggaccagg cgatcaccgc actcctcacc 780
gaccccgggc aactcgccca tgtccgcgcc ggacgcgcgg gctggaagga cgtggtcgag 840
gaatcactcc gccacgaggc cccgctcgcg catctgccga tgcgcttcgc cgtggaggac 900
atccccctcc ccgaacacgg cgtgaccatc cggcagggcg acgccgtcct gcccgcctac 960
gccgccgcca accggcatcc ggacctgcac ggcctcaccg ccgacgactt cgacgccacc 1020
cggagcgaca agagccatct ctccttcgga cacggcatgc acctctgcct cggagccgcc 1080
ctcggtcgcc tcgaagccga aatcgccctg cgcggcctct tcgaacgctt cccccgtctc 1140
gccctcgccg tgcccctgga ccgactgcgc cccaagccga gcttcatctc caacggccac 1200
agcgaactgc ccgtcatcat cgacccgtag 1230
<210> 16
<211> 395
<212> PRT
<213> Streptomyces sp. GT1005
<400> 16
Val Gly Thr Pro Gln Pro Asp Val Ala Glu Gly Leu Thr Pro Val Glu
1 5 10 15
Ala Ala Arg Ser Leu Val Pro Leu Leu Ala Ala Glu Ala Ala Arg Thr
20 25 30
Glu Glu Arg Arg Ala Leu Thr Gly Ala Thr Val Thr Gly Leu Arg Arg
35 40 45
Ala Gly Leu Leu Arg Leu Gly Thr Pro Thr Glu Cys Gly Gly Arg Gly
50 55 60
Ala Gly Ala Arg Thr Ala Val Asp Val Cys Glu Glu Leu Ala Lys Gly
65 70 75 80
Cys Ala Ser Ala Ser Trp Ile Val Gly Ile Ala Tyr Gly Gly Ala Leu
85 90 95
Phe Ala Ser Gln Leu Pro His Ser Glu Arg Ala Ala Leu Trp Arg Asp
100 105 110
Asp Pro Asp Ala Val Val Cys Gly Ser Ala Asn Pro Ser Gly Thr Ala
115 120 125
Arg Arg Thr Asp Gly Gly Trp Thr Leu Ser Gly Arg Trp Pro Trp Ile
130 135 140
Ser Gly Ile His His Ala Pro Trp Thr Leu Leu Gly Phe Val Arg Pro
145 150 155 160
Gly Ala Gly Gly Glu Pro Glu Arg Gly Met Ala Val Val Pro Thr Ala
165 170 175
Gly Leu Thr Val Glu Asp Val Trp His Met Ala Gly Met Arg Gly Thr
180 185 190
Gly Ser Asp Thr Ala Val Ala Asp Gly Val Tyr Val Pro Asp Ser Arg
195 200 205
Thr Ile Ser Leu Thr Ala Met Ala Asp Gly Ala Tyr Arg Arg Arg His
210 215 220
Pro Gly Glu Pro Arg Val Thr Phe His Leu Ser Ile Asn Leu Pro Leu
225 230 235 240
Val Ala Thr Ala Val Gly Ile Ala Thr Ala Ser Leu Glu Lys Val Leu
245 250 255
Asp Ala Ala Ala Arg Gly Lys Gln Thr Val Ser Pro Leu His Arg Leu
260 265 270
Val Ala Glu Asp Ser Ala His Gln Leu Asn Val Ala Asp Ala Ala Thr
275 280 285
Leu Ile Asp Thr Ala Arg Leu His Leu Arg Arg Ala Ala Asp Glu Val
290 295 300
Asp Ser His Ala Arg Ala Gly Arg Arg Pro Ala Leu Ala Glu Arg Ala
305 310 315 320
Arg Leu Arg Met Asp Ala Ala His Ala Met Arg Cys Ala Arg Asp Ala
325 330 335
Val Ser Leu Leu Leu Asp Thr Ala Gly Ala Gly Ser Phe Ala Asp Gly
340 345 350
Ser Val Leu Gln Arg Ala Trp Arg Asp Ile Glu Thr Ala Ser Arg His
355 360 365
Ala Ala Leu Ser Val Gln Thr Ser Lys Glu Ile Tyr Gly Arg Ala Leu
370 375 380
Leu Gly Ala Pro Leu Pro Pro Gly Pro Val Val
385 390 395
<210> 17
<211> 1188
<212> DNA
<213> Streptomyces sp. GT1005
<400> 17
gtgggcactc ctcaacccga tgtcgccgag ggcctcacgc cggtcgaggc ggcgcgctca 60
ctggtcccgc tgctcgctgc cgaagcggcc cgcaccgagg agcggcgcgc cctcaccggc 120
gccactgtga ccggcctgcg ccgggccggt ctgctccgcc tcgggacccc gaccgagtgc 180
ggcggccggg gtgcgggtgc ccgtaccgcg gtggatgtgt gcgaggagct ggccaagggc 240
tgtgcgtccg cctcctggat cgtgggcatc gcctacggcg gcgccctctt cgcctcccag 300
cttccccact ccgagcgtgc ggccctgtgg cgggacgacc cggacgctgt cgtctgcggc 360
agcgccaacc cgtccggaac ggcgcggcgt acggacggcg gctggaccct gagcggccgt 420
tggccctgga tctccggcat ccaccatgcg ccctggaccc tgctcggctt cgtccggccc 480
ggcgcagggg gcgaaccgga gcgcggcatg gccgtggtcc ccaccgccgg cctgaccgtc 540
gaggacgtct ggcatatggc gggcatgcgc ggcaccggca gcgacacggc cgtcgcggac 600
ggcgtgtacg tgccggactc ccgcacgatc tccctgaccg ccatggcgga cggcgcctac 660
cggcgacgcc atcccggcga accccgggtc accttccatc tctccatcaa cctgccgttg 720
gtggcgacgg ccgtcgggat cgccacagcg tccctggaga aggtgctgga tgccgcggcc 780
cggggcaaac agacggtctc cccgctgcac cggctggtcg ccgaggactc cgcccatcag 840
ctcaatgtgg cggacgccgc gacgctcatc gacacggccc ggctgcatct gcgccgcgcc 900
gccgacgagg tggactccca cgcccgcgcg gggcgccgtc ccgcgctcgc cgagcgggcc 960
cgactgcgga tggacgccgc ccacgccatg cgctgcgccc gcgacgccgt gagcctgctg 1020
ctggacaccg cgggcgcggg cagcttcgcg gacggctcgg tcctgcaacg ggcctggcgc 1080
gatatcgaga cggcgtcccg gcacgccgcg ctcagcgtcc agaccagcaa ggagatatac 1140
ggccgcgctc tgctcggcgc cccgctgccg cccggcccgg tcgtctga 1188
<210> 18
<211> 250
<212> PRT
<213> Streptomyces sp. GT1005
<400> 18
Met Thr Thr Ala Gly Leu Arg Val Ala Leu Val Thr Gly Ala Gly Arg
1 5 10 15
Gly Ile Gly Ala Ala Ile Ala Glu Arg Leu His Gly Ser Gly His Arg
20 25 30
Val Ala Leu Leu Asp Arg Asp Gly Asp Ala Val Thr Gly Leu Ser Ala
35 40 45
Ala Leu Asp Pro Ala Gly Ala Gly Thr Ala Leu Pro Leu Arg Ala Asp
50 55 60
Val Asp Asp Thr Asp Ala Val His Ala Ala Leu Arg Glu Thr Ala Ala
65 70 75 80
Ala Trp His Ala Pro Asp Ile Leu Ile Asn Asn Ala Ala Arg Thr Ala
85 90 95
Pro Gly Ser Val Trp Asp Ile Glu Pro Asp Glu Trp Asp Ala Val Leu
100 105 110
Thr Thr Asn Leu Arg Ser Val Leu Thr Leu Thr Arg Leu Cys Ala Pro
115 120 125
Ala Met Arg Asp Arg Gly Trp Gly Arg Val Val Asn Leu Ser Ser Leu
130 135 140
Ala Gly Gln Gln Gly Gly Thr Leu Ala Gly Ala His Tyr Ser Ala Ala
145 150 155 160
Lys Ala Gly Val Leu Val Leu Thr Lys Val Phe Ala Arg Glu Leu Ala
165 170 175
Ala His Gly Val Thr Val Asn Ala Val Ala Pro Ala Ala Val Asp Thr
180 185 190
Pro Ala Val Ala Gly Leu Gly Pro Ser Ala Val Ala Glu Ala Ala Arg
195 200 205
Gln Ile Pro Val Gly Arg Met Gly Arg Pro Ser Glu Val Ala Gly Leu
210 215 220
Val Ala Tyr Leu Val Gly Glu Glu Gly Gly Tyr Val Thr Gly Ala Thr
225 230 235 240
Phe Asp Ile Asn Gly Gly Thr His Met Arg
245 250
<210> 19
<211> 753
<212> DNA
<213> Streptomyces sp. GT1005
<400> 19
atgacgacgg caggcctccg ggtggcgctg gtcaccggcg cgggacgcgg tatcggggcc 60
gcgatcgccg aacggctgca cgggtccggc caccgggtgg ccctgctgga ccgcgacggc 120
gacgccgtga ccgggctgtc cgccgccctc gaccccgccg gcgcgggcac cgcgctgccg 180
ctgcgtgcgg acgtcgacga cacggacgcc gtccacgccg cgctgcgcga gaccgccgcc 240
gcctggcacg cgcccgacat cctgatcaac aatgccgccc ggaccgcccc cggctcggta 300
tgggacatcg aaccggacga atgggacgcc gtactgacga ccaatctgcg cagcgtcctg 360
accctgaccc ggctgtgcgc gcccgcgatg cgcgaccgcg gctggggccg ggtggtcaac 420
ctctcctcgc tggccggtca gcagggcggc accctcgccg gcgcccacta ctccgccgcc 480
aaggcgggcg ttctcgtgct gaccaaggtg ttcgcccgtg aactggcggc gcacggcgtg 540
accgtcaacg cggtagcccc ggccgccgtc gacaccccgg cggtcgccgg gctcggcccg 600
tcggcggtgg ccgaggcggc ccggcagatc ccggtgggcc ggatggggag gccttcggag 660
gtcgccggcc tcgtggccta tctggtgggc gaagagggcg gatacgtcac cggcgccacc 720
ttcgacatca acggcggcac ccatatgcgc tga 753
<210> 20
<211> 222
<212> PRT
<213> Streptomyces sp. GT1005
<400> 20
Met Ala Asn Gln Val Thr Met Ser Asp Ala Leu Leu Ala Tyr Val Arg
1 5 10 15
Lys Val Ser Leu Arg Asp Asp Arg Val Leu Gly Gly Leu Arg Ala Glu
20 25 30
Ser Ala Gly Leu Pro Gly Gly Asn Ala Leu Pro Val Ser Ala Glu Glu
35 40 45
Gly Gln Phe Leu Glu Phe Leu Val Arg Leu Thr Gly Ala Arg Gln Val
50 55 60
Leu Glu Ile Gly Thr Tyr Thr Gly Tyr Ser Thr Leu Cys Leu Ala Arg
65 70 75 80
Gly Leu Pro Pro Gly Ala Arg Val Val Thr Cys Asp Asn Thr Ala Lys
85 90 95
Trp Pro Glu Val Gly Arg Pro Tyr Trp Glu Arg Ala Gly Val Ala Glu
100 105 110
Arg Ile Asp Val Arg Ile Gly Asp Ala Leu Asp Val Leu Ala Gly Leu
115 120 125
Arg Asp Glu Pro Gly Ala Gly Pro Gly Ser Phe Asp Val Val Phe Ile
130 135 140
Asp Ala Asp Lys Glu Arg Tyr Pro Ala Tyr Tyr Glu Ala Ala Leu Pro
145 150 155 160
Leu Val Arg Gly Gly Gly Leu Ile Val Val Asp Asn Thr Leu Phe Phe
165 170 175
Gly Arg Val Ala Asp Asp Ala Val Thr Asp Pro Glu Thr Thr Ala Ile
180 185 190
Arg Ala Leu Asn Ala Gly Leu Arg Asp Asp Asp Arg Val Asp Leu Ala
195 200 205
Met Leu Ala Ser Ala Asp Gly Ile Thr Leu Leu Arg Lys Arg
210 215 220
<210> 21
<211> 669
<212> DNA
<213> Streptomyces sp. GT1005
<400> 21
atggcgaatc aggtgaccat gtccgacgcg ctgctcgctt acgtccggaa ggtgtcactg 60
cgggacgaca gggtgctggg cggtctgcgg gcggagtcgg cagggctgcc ggggggcaac 120
gctctgccgg tatccgccga agagggccag ttcctggaat tcctggtgcg gttgaccggc 180
gcccgtcagg tgctggagat cgggacgtac accggctaca gcaccctctg tctggcccgc 240
gggctgccgc ccggggcccg ggtggtgacg tgcgacaaca cggcgaagtg gccggaggtg 300
ggcaggccgt actgggagcg ggccggggtg gccgaacgga tcgacgtacg gatcggcgac 360
gccctggacg tgctggccgg actccgcgac gagccgggcg cgggaccggg gtcgttcgat 420
gtcgtgttca tcgacgccga caaggaacgc tatccggcct actacgaggc ggctctgccg 480
ctggtgcgcg gcggtggcct gatcgtcgtc gacaacacgc tgttcttcgg acgggtggcc 540
gacgacgcgg tgacggaccc ggagacgaca gcgatccgcg cactcaatgc ggggctgcgc 600
gacgacgatc gggtggacct ggccatgctg gcgtcggccg acggcatcac cttgttgcgg 660
aagcggtga 669
<210> 22
<211> 362
<212> PRT
<213> Streptomyces sp. GT1005
<400> 22
Met Thr Thr Thr Thr Ile Val Lys Cys Leu Val Trp Asp Leu Asp Asn
1 5 10 15
Thr Leu Trp Arg Gly Thr Val Leu Glu Asp Ala Asp Val Val Leu Thr
20 25 30
Asp Ala Val Arg Asp Val Val Arg Ala Leu Asp Gly Arg Gly Ile Leu
35 40 45
Gln Ala Val Ala Ser Lys Asn Asp His Asp Leu Ala Trp Lys His Leu
50 55 60
Glu Arg Leu Gly Met Ala Glu Tyr Phe Val Leu Pro His Ile Gly Trp
65 70 75 80
Gly Pro Lys Ser Gln Ser Val Arg Ala Ile Ala Glu Arg Leu Asn Phe
85 90 95
Ala Pro Ser Thr Leu Ala Phe Val Asp Asp Gln Pro Ala Glu Arg Ala
100 105 110
Glu Val Ala Phe His Leu Pro Glu Val Arg Cys Tyr Ala Ala Glu Gln
115 120 125
Val Thr Ala Leu Pro Thr Leu Pro Glu Phe Ser Pro Pro Glu Ser Thr
130 135 140
Val Asp Ser Arg Arg Arg Arg Leu Met Tyr Gln Ala Gly Phe Ala Arg
145 150 155 160
Asp His Ala Arg Glu Ala Trp Ser Gly Pro Asp Asp Asp Phe Leu Arg
165 170 175
Ser Leu Asp Leu Arg Met Thr Ile Ala Pro Ala Gly Pro Glu Glu Ile
180 185 190
Thr Arg Val Glu Glu Leu Thr Leu Arg Thr Ser Gln Met Asn Ala Thr
195 200 205
Gly Val His Tyr Ser Asp Ala Ala Leu Arg Ala Leu Leu Ala Asp Pro
210 215 220
Gly His Glu Val Leu Val Val Thr Met Gly Asp Arg Phe Gly Pro His
225 230 235 240
Gly Ala Val Gly Ile Val Leu Leu Ala Thr Gln Pro Gln Val Trp His
245 250 255
Leu Lys Leu Leu Ala Thr Ser Cys Arg Val Val Ser Phe Gly Ala Gly
260 265 270
Ala Val Ile Leu Asp Trp Leu Thr Asp Arg Ala Ala Arg Ala Gly Val
275 280 285
His Leu Met Ala Asp Phe Arg Arg Thr Glu Arg Asn Arg Leu Met Glu
290 295 300
Val Ala Tyr Arg Phe Ala Gly Phe Met Glu Ser Gly Cys Ala Cys Ala
305 310 315 320
Ser Pro Leu Gly Glu Pro Ala Gly Gly Val Glu Arg Leu His Leu Glu
325 330 335
Pro Ser Pro Arg Pro Gly Pro Arg Thr Leu Thr Leu Thr Ala Ala Gly
340 345 350
Ser Ile Pro Phe Thr Ala Ser Ala Thr Arg
355 360
<210> 23
<211> 1089
<212> DNA
<213> Streptomyces sp. GT1005
<400> 23
atgaccacca cgaccatcgt caaatgcctg gtctgggatc tggacaacac cttgtggcgc 60
ggcaccgtgc tggaagacgc cgacgtggta ctcaccgacg cggtccgcga cgtcgtccgc 120
gcactcgacg gccgcggcat tctccaggcg gtcgccagca agaacgacca cgacctcgcc 180
tggaagcacc tcgaacggct cggcatggcc gagtacttcg ttctgccgca catcggatgg 240
gggccgaaat cgcaatccgt ccgggccatc gccgaaaggc tgaacttcgc cccgtcgacg 300
ctcgccttcg tcgacgacca gcccgccgag cgcgccgagg tcgcgttcca tctccccgaa 360
gtgcgctgct acgcagccga gcaggtgacc gcgctcccca ccctgcccga gttcagcccc 420
ccggaatcca cggtcgactc acgccgccga cgcctcatgt accaggccgg attcgcgcgt 480
gaccacgcac gagaggcctg gtccggcccc gacgacgact tcctgcgctc cctggacctg 540
agaatgacga tcgcgcccgc gggccccgag gagatcaccc gcgtcgagga gctgacgctg 600
cggaccagtc agatgaacgc gaccggcgtg cactactccg acgcggcact gcgggcgctg 660
ctcgcagacc ccggccacga ggtcctcgtc gtcaccatgg gcgaccgctt cggcccgcac 720
ggcgccgtcg gcatcgtcct gctcgcgacg caaccgcagg tgtggcacct gaagctgctc 780
gcgacgtcct gccgggtggt gtcgttcggt gccggtgcgg tgatcctcga ctggctcacg 840
gaccgggccg cccgggccgg cgtccatctg atggccgact tccggcgcac ggaacgcaac 900
cgtctgatgg aggtcgccta ccggttcgcc gggttcatgg agagcggctg cgcctgcgcg 960
tcgccgctgg gggagccggc cggtggtgtg gaacggctgc atctggagcc ctcgccgcga 1020
cccgggccga ggaccctgac actgaccgcc gcgggcagta tcccgttcac cgcttccgca 1080
acaaggtga 1089
<210> 24
<211> 366
<212> PRT
<213> Streptomyces sp. GT1005
<400> 24
Met Pro Asp His Gln Ala Leu Leu Thr Gly Leu Val Gly Asp Arg Ala
1 5 10 15
Ala Gly Trp Asp Val Ser Gly Glu Leu Pro Arg Asp Leu Leu Val Arg
20 25 30
Leu Gly Ala Glu Gly Leu Leu Cys Ala Glu Val Glu Ala Gly Tyr Gly
35 40 45
Gly Leu Gly Leu Gly Ser Arg Gly Asn Gly Glu Leu Thr Ala His Val
50 55 60
Gly Ser Leu Cys Ser Ser Leu Arg Ser Val Met Thr Ser Gln Gly Met
65 70 75 80
Ala Ala Trp Thr Val Leu Arg Ile Gly Gly Thr Ala Gln Arg Glu Thr
85 90 95
Tyr Leu Lys Glu Leu Thr Ser Gly Lys Leu Ala Ala Val Gly Phe Ser
100 105 110
Glu Arg Gln Ala Gly Ser Asp Leu Ser Ala Ile Arg Thr Arg Val Arg
115 120 125
Ile Glu Gly Asp Thr Ala Val Val Asp Gly His Lys Val Trp Thr Thr
130 135 140
Ala Ala Ala Tyr Ala Asp His Leu Val Val Phe Gly Leu Gln Glu Asp
145 150 155 160
Gly Ser Gly Ala Val Val Val Val Pro Ser Asp Thr Ala Gly Leu Arg
165 170 175
Val Glu Arg Val Pro Asn Pro Ser Gly Cys Arg Ala Ala Gly His Ala
180 185 190
His Leu Tyr Phe Asp Gly Val Arg Val Pro Ala Asp Ala Val Leu Ala
195 200 205
Gly Ser Gly Ala Ser Leu Pro Met Leu Val Ala Val Ser Leu Ala Tyr
210 215 220
Gly Arg Thr Ser Val Ala Trp Gly Cys Leu Gly Ile Leu Arg Ala Cys
225 230 235 240
Thr Ala Ala Ala Thr Ala His Ala Lys Ser Arg Glu Gln Phe Gly Gln
245 250 255
Pro Leu Ala Gly His Gln Leu Val Ala Gly His Leu Ala Asp Leu Trp
260 265 270
Thr Ala Glu Gln Ile Ala Ala Arg Val Cys Glu His Ala Ser Asp Leu
275 280 285
Trp Asp Glu Gly Ser Pro Glu Ala Val Thr Ala Thr Val Leu Ala Lys
290 295 300
His Val Ala Ala Glu Arg Ala Ala Ala Gly Ala Ala Leu Ala Ala Gln
305 310 315 320
Ile Leu Ala Ser Ala Gly Ala Ile Glu Gly His Val Val Glu Arg Ala
325 330 335
Tyr Arg Asp Ala Lys Leu Met Glu Ile Ile Glu Gly Ser Ser Glu Met
340 345 350
Ser Arg Met Met Leu Ala Arg His Ala Leu Ala Leu Pro Ala
355 360 365
<210> 25
<211> 1101
<212> DNA
<213> Streptomyces sp. GT1005
<400> 25
atgcctgatc accaggcgct gctgaccggg ctcgtgggcg accgggctgc cggctgggac 60
gtctccggcg aactgccgcg cgacctcctc gtccggctcg gcgccgaagg cctgctctgc 120
gcggaggtcg aggccgggta cggcggcctc ggcctcggca gccgcggcaa cggcgagctc 180
accgcgcacg tcggcagtct ctgcagctca ctccggagcg tcatgacatc gcagggaatg 240
gccgcctgga ccgtgctgag gatcggcggc accgcccagc gcgagaccta tctgaaggag 300
ctgaccagcg ggaaactcgc ggccgtcggc ttcagcgaac ggcaggccgg cagcgatctg 360
tcggcgatcc ggacccgggt gcggatcgaa ggagacaccg ccgtcgtcga cggccacaag 420
gtctggacga ccgcggccgc gtacgcggac cacctggtcg tcttcggcct gcaggaggac 480
ggctccggcg cggtcgtcgt cgtgccgtcg gacactgcgg gcctacgggt cgaacgggtc 540
ccgaacccgt cgggatgccg cgccgcgggc cacgcccacc tgtacttcga cggagtacgg 600
gtaccggcgg acgcggtcct cgccggctcc ggggcgtcgc tcccgatgct cgtcgcggtg 660
tcactcgcgt acggccgcac ctcggtcgcc tggggctgcc tcgggatcct gcgcgcctgc 720
accgccgccg cgacagccca cgcgaagagc cgggaacagt tcgggcaacc gctcgccgga 780
catcagctcg tcgccgggca tctcgccgac ctgtggaccg cggagcagat cgcggcgcgc 840
gtgtgcgagc acgcgagcga cctctgggac gagggctcac ccgaggcggt gaccgcgacg 900
gtcctggcga agcacgtcgc cgccgagcgg gccgccgcgg gcgccgcgct cgccgcacag 960
atactcgcgt cggccggagc gatcgaagga cacgtcgtcg agcgggcgta ccgcgacgcc 1020
aagctcatgg agatcatcga aggcagcagc gagatgagcc ggatgatgct cgcgcggcac 1080
gcgctggccc tcccggcctg a 1101
<210> 26
<211> 86
<212> PRT
<213> Streptomyces sp. GT1005
<400> 26
Val Thr Val Pro Val Thr Asp Asp Pro Val Ala His Glu Leu Val Ala
1 5 10 15
Phe Leu Glu Lys Lys Thr Gly Ser Pro Trp Ser Val Glu Arg Asp Leu
20 25 30
Phe Ala Glu Gly Gly Leu Ser Ser Leu Phe Ala Leu Glu Leu Val Val
35 40 45
Phe Leu Glu Lys Thr Phe Ser Ile Thr Ile Ser Gly Pro Asp Leu Gln
50 55 60
Leu Val Asn Tyr Arg Ser Val Val Ser Met Val Gly Leu Val His Arg
65 70 75 80
Leu Arg Thr Gly Asp Ala
85
<210> 27
<211> 261
<212> DNA
<213> Streptomyces sp. GT1005
<400> 27
gtgaccgttc ccgtcacaga cgaccccgtc gcccacgagc tggtcgcatt cctggagaag 60
aagaccggat cgccctggtc ggtggagcgc gacctgttcg cggaaggagg cctctcgtcg 120
ctgttcgccc tggagctggt ggtcttcctg gagaagacgt tcagcatcac catcagcgga 180
cccgacctcc agctcgtgaa ctaccgcagc gtcgtgtcca tggtcggcct cgtccaccgg 240
ctgcggaccg gcgatgcctg a 261
<210> 28
<211> 292
<212> PRT
<213> Streptomyces sp. GT1005
<400> 28
Val Val Thr Pro Ala Gly Gly Ser Gly Thr Glu Arg Arg Ile Leu Val
1 5 10 15
Leu Gly Ala Gly Val Met Gly Thr Gly Ile Thr Thr Leu Ala Leu Arg
20 25 30
His Gly Val His Val Thr Leu Val Asp Thr Ser Glu Thr Ile Leu Ala
35 40 45
Ala Ala Arg Lys Arg Ile Ala Ala Glu Leu Arg Met Ala His Leu Leu
50 55 60
Thr Gly Pro Ala Glu Ala Asp Pro Gly Glu Leu Thr Thr Val Thr Ser
65 70 75 80
Ala Arg Thr Glu Pro Gly Thr Ala Thr Ala Val Ile Glu Ala Val Val
85 90 95
Glu Asp Ala Thr Val Lys Ala Gln Val Leu Ala Ala Val Ser Ala Ala
100 105 110
Val Pro Pro Gly Thr Pro Ile Ile Thr Asn Thr Ser Ser Ile Pro Val
115 120 125
Asp Glu Leu Ala Asp Ala Val Ala Arg Pro Gln Asp Leu Leu Gly Thr
130 135 140
His Phe Met Asn Pro Ser Tyr Ala Ile Pro Met Val Glu Val Val Arg
145 150 155 160
Gly Pro Arg Ser Gly Glu Ala Ala Met Ala Ala Ala Ala Asp Leu Leu
165 170 175
Ala Val Leu Gly Arg Lys Ala Ile Val Val Arg Asp Ala Pro Gly Phe
180 185 190
Val Thr Ser Arg Leu Leu His Pro Met Ile Asn Asp Ala Ala Arg Val
195 200 205
Val Gln Glu Gly Thr Ala Ser Val Glu Asp Val Asp Ala Leu Met Thr
210 215 220
Gly Cys Leu Gly His Pro Thr Gly Pro Leu Arg Thr Ala Asp Leu Ile
225 230 235 240
Gly Ile Asp Asn Leu Val Asp Ala Leu Trp Val Leu His Lys Arg Thr
245 250 255
Gly Asp Asp Arg Ser Arg Pro Cys Asp Leu Leu Leu Thr Lys Val Arg
260 265 270
Asp Gly His His Gly Arg Lys Thr Gly Arg Gly Phe Tyr Pro Tyr Glu
275 280 285
Glu Val Phe Arg
290
<210> 29
<211> 879
<212> DNA
<213> Streptomyces sp. GT1005
<400> 29
gtggtgacgc cggccggggg aagcggaacg gaacggcgga tcctcgtcct cggcgcggga 60
gtgatgggca ccgggatcac cacgctcgcg ctgcgccacg gcgtccacgt cacactcgtc 120
gacacgtccg agaccattct ggcggcggcg cggaaacgga tcgccgccga gctgcggatg 180
gcgcacctcc tgacgggtcc cgccgaggcg gaccccggcg agctgacaac ggtgacatcg 240
gcgcggaccg agcccggcac tgccaccgcg gtgatcgaag ccgtcgtcga ggacgcgacg 300
gtcaaggcac aggtcctcgc cgccgtctcg gcggcggtgc cgcccggcac cccgatcatc 360
acgaacacgt cgtcgatccc cgtcgacgag ctggccgacg ccgtggcccg gccgcaggac 420
ctcctcggca cgcacttcat gaacccgtcg tatgcgatcc cgatggtcga ggtggtccgc 480
gggccccgca gcggggaggc ggccatggcc gccgccgcgg atctgctcgc ggtcctcggc 540
cgcaaggcga tcgtcgtccg cgacgcgccc ggtttcgtca cgagccggct gctccacccg 600
atgatcaacg acgcggcgcg ggtcgtccag gagggcaccg cgtccgtcga ggacgtcgac 660
gcgctgatga cgggctgcct cggccacccg accggcccgc tgcgcaccgc ggacctcatc 720
ggcatcgaca acctcgtcga cgcgctgtgg gtgctgcaca agcgcaccgg cgacgaccgc 780
agccgtccct gcgacctgct cctcaccaag gtccgggacg ggcaccacgg ccggaagacc 840
gggcgtggct tctaccccta cgaagaggtg ttccggtga 879
<210> 30
<211> 345
<212> PRT
<213> Streptomyces sp. GT1005
<400> 30
Met Gln Thr Lys Ile Leu Arg Gln Arg Asp Ile Lys Gln Ile Leu Ser
1 5 10 15
Val Val Gly Arg Asp Thr Ile Met Asp Arg Leu Ile Gln Glu Leu Tyr
20 25 30
Asp Gly Phe Ala Ala Leu Gly Arg Gly Glu Leu Ala Glu Ala Pro Pro
35 40 45
Arg Ser Gly Phe Ala Arg Ser Gly Glu Ile Pro Gly Val Ile Glu Phe
50 55 60
Met Pro Tyr Arg Val Pro Gly Val Ala Val Thr Met Lys Thr Val Ser
65 70 75 80
Tyr Ser Pro His Asn Tyr Gln Arg Phe Arg Leu Pro Thr Val Val Gly
85 90 95
Thr Val Ser Arg Leu Asp Asp Asp Ser Gly Ser Leu Ile Ala Leu Ala
100 105 110
Asp Ala Gly Val Ile Thr Ala Met Arg Thr Gly Ala Val Ser Ala Val
115 120 125
Ala Ser Arg Leu Leu Ala Arg Pro Asp Ser Ser Thr Leu Ala Leu Ile
130 135 140
Gly Ala Gly Ala Gln Ala Val Thr Gln Ala His Ala Leu Ser Arg Val
145 150 155 160
Leu Pro Val Glu Arg Ile Leu Val Ser Asp Ile Asp Pro Ala His Ala
165 170 175
Ala Ser Phe Ala Gly Arg Ile Ala Phe Leu Gly Leu Pro Val Glu Ile
180 185 190
Thr Gly Pro Ala Glu Ala Val Ala Ala Ala Asp Val Leu Ser Thr Val
195 200 205
Thr Ser Val Pro Ala Gly Gln Gly Pro Val Leu Pro Ala Glu Pro Arg
210 215 220
Leu Ala His Leu His Val Asn Ala Thr Gly Ala Asp Glu Pro Gly Lys
225 230 235 240
Thr Glu Leu Pro Lys Ala Leu Leu Asp Asp Ala Phe Ile Cys Val Asp
245 250 255
His Pro Gly Gln Ala Arg Ala Glu Gly Glu Phe Gln Gln Leu Pro Asp
260 265 270
Arg Pro Leu Gly Pro Ser Leu Ala Ser Leu Cys Ala Ala Pro Arg Thr
275 280 285
Ala Ala Ala Tyr Ile Gly Ser Leu Ser Val Leu Asp Ser Thr Gly Ser
290 295 300
Ala Phe Ala Asp His Ile Ala Phe Asp Val Leu Leu Gly Phe Ala Asp
305 310 315 320
Glu Leu Gly Leu Gly Arg Lys Ala Ala Ile Gly Ala Thr Pro Asp Asp
325 330 335
Val Leu Asp Pro Tyr Ser Leu Pro Trp
340 345
<210> 31
<211> 1038
<212> DNA
<213> Streptomyces sp. GT1005
<400> 31
atgcagacca agatcctgcg tcagcgcgat atcaagcaga tcctctccgt ggtcggccgc 60
gacacgataa tggaccggct gatccaagag ctgtacgacg gcttcgccgc gctcggccgg 120
ggagagctcg ccgaggcgcc gccacgcagt ggcttcgccc ggagcggcga gatccccggc 180
gtcatcgagt tcatgccgta ccgggtgccc ggtgttgccg tgaccatgaa gaccgtttcg 240
tacagtccgc acaactatca gcgattccgg ctgccgacgg tcgtcggcac ggtgtcgcgc 300
ctcgacgacg acagcggcag tctgatcgcg ctcgccgacg cgggtgtgat caccgcgatg 360
cgcacgggcg cggtctcggc cgtcgcgagc cggctgctgg ccagacccga cagctccacc 420
ctcgcgctga tcggagccgg cgcacaggcg gtgacccagg cacacgcact cagcagggtc 480
ctgcccgtcg agcggatcct ggtcagcgat atcgacccgg cgcacgcggc gtccttcgcg 540
ggccggatcg ccttcctcgg gctccccgtc gaaatcaccg gccctgccga agcggtcgcc 600
gccgccgacg tcctgagcac cgtcacatcg gtgcccgcgg gacagggccc ggtgctcccc 660
gccgagccgc gcctggcaca cctccacgtc aacgcgaccg gtgccgacga gccgggcaag 720
accgagctgc cgaaggccct gctcgacgat gcgttcatct gcgtcgacca ccccgggcag 780
gcccgtgccg aaggcgaatt ccagcagctg cccgaccgcc cgctcggacc gtcgctggcg 840
agcctctgcg cggcgccccg caccgccgct gcgtacatcg gcagcctgag cgtcctcgac 900
tcgaccggca gcgccttcgc cgaccacatc gcgttcgacg tactgctcgg cttcgccgat 960
gaactcggtc tcggccgcaa agccgcgatc ggggcgacac cggacgacgt cctcgacccc 1020
tactcgctgc cgtggtga 1038
<210> 32
<211> 3559
<212> PRT
<213> Streptomyces sp. GT1005
<400> 32
Met Ala Cys Arg Leu Pro Gly Gly Ile Thr Ser Pro Glu Glu Leu Trp
1 5 10 15
Glu Leu Val Glu Ala Gly Gly Asp Ala Val Gly Asp Phe Pro Thr Asp
20 25 30
Arg Gly Trp Asp Val Ala Ala Leu His Ala Asp Ala Glu Ser Ala Thr
35 40 45
Ser Arg Ala Gly Ala Leu Arg Gly Ala Gly Asp Phe Asp Ala Ala Phe
50 55 60
Phe Gly Ile Ser Pro Arg Glu Ala Thr Ala Leu Asp Pro Gln Gln Arg
65 70 75 80
Ile Leu Leu Glu Ile Ala Trp Glu Ala Leu Glu Arg Ala Gly Ile Val
85 90 95
Pro Asp Thr Leu Arg Gly Thr Asp Thr Gly Val Phe Val Gly Gly Phe
100 105 110
Tyr Tyr Gly Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Tyr
115 120 125
Ser Thr Gln Pro Ala Val Leu Ala Gly Arg Leu Ser Tyr Phe Phe Gly
130 135 140
Leu Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
145 150 155 160
Val Ala Leu His Gln Ala Gly Gln Ala Leu Arg Ser Gly Glu Cys Ser
165 170 175
Leu Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Gln Ser Phe
180 185 190
Val Glu Phe Ser Arg Gln Gly Gly Val Ala Ser Asp Gly Arg Cys Lys
195 200 205
Ala Phe Ala Asp Thr Ala Asp Gly Thr Gly Phe Ala Glu Gly Ala Gly
210 215 220
Val Leu Val Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Ser
225 230 235 240
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
245 250 255
Asn Gly Leu Ser Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg
260 265 270
Gly Ala Leu Glu Arg Ala Gly Leu Gly Pro Ala Asp Val Asp Val Val
275 280 285
Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp Pro Ile Glu Ala Gln
290 295 300
Ala Val Ile Ala Val Tyr Gly Gln Gly Arg Glu Val Pro Leu Tyr Leu
305 310 315 320
Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val
325 330 335
Ala Gly Val Ile Lys Met Val Leu Ala Met Arg Tyr Gly Val Leu Pro
340 345 350
Arg Thr Leu His Val Gly Glu Pro Ser Ser His Val Asp Trp Ser Ala
355 360 365
Gly Ala Val Glu Leu Leu Thr Glu Ala Arg Pro Trp Pro Glu Ser Gly
370 375 380
Arg Ala Arg Arg Ala Gly Val Ser Gly Phe Gly Val Ser Gly Thr Asn
385 390 395 400
Ala His Val Val Leu Glu Gly Val Pro Glu Val Ser Val Ser Ala Ala
405 410 415
Glu Pro Glu Ser Gly Gly Leu Val Pro Leu Pro Val Ser Ala Arg Ser
420 425 430
Gly Val Gly Val Gly Val Leu Val Glu Arg Val Gly Gly Leu Val Gly
435 440 445
Gly Gly Cys Asp Val Gly Val Val Ala Asp Gly Leu Val Arg Gly Arg
450 455 460
Ala Val Phe Gly His Arg Ala Val Leu Leu Gly Glu Ser Arg Val Thr
465 470 475 480
Gly Val Ala Gly Glu Gly Leu Arg Thr Val Phe Val Phe Pro Gly Gln
485 490 495
Gly Ser Gln Trp Val Gly Met Gly Val Glu Leu Met Gly Trp Ser Glu
500 505 510
Val Phe Ala Arg Arg Met Gly Glu Cys Ala Ala Ala Leu Lys Pro Phe
515 520 525
Thr Gly Trp Asp Leu Gly Glu Val Leu Ala Gly Arg His Asp Ser Gly
530 535 540
Ala Val Glu Val Val Gln Pro Leu Ser Trp Ala Val Ala Val Ser Leu
545 550 555 560
Ala Ala Leu Trp Gly Ala His Gly Val Val Pro Asp Val Val Val Gly
565 570 575
His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser
580 585 590
Leu Glu Asp Gly Ala Arg Val Val Ala Leu Arg Ser Arg Val Ile Ala
595 600 605
Gly Arg Leu Ala Gly Arg Gly Val Met Ala Ser Val Ala Leu Pro Ala
610 615 620
Ala Asp Ile Glu Thr Val Glu Gly Val Trp Ile Ala Ala Arg Asn Gly
625 630 635 640
Pro Ser Ser Thr Val Ile Ala Gly Asp Ala Gln Ala Val Glu Gly Val
645 650 655
Leu Ala Arg Cys Glu Thr Ala Gly Val Arg Val Arg Arg Ile Ala Val
660 665 670
Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile Glu Asp Glu Leu
675 680 685
Ala Glu Val Leu Glu Gly Val Thr Thr Arg Thr Pro Val Ile Pro Trp
690 695 700
Trp Ser Thr Val Asp Ser Gly Trp Val Glu Glu Pro Val Asp Asp Gly
705 710 715 720
Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Leu Asp Thr Ala Ile
725 730 735
Thr Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser Ala His Pro Val
740 745 750
Leu Leu Pro Ala Ile Asp Gln Gln Arg Thr Val Ala Ser Leu Arg Thr
755 760 765
Asp Asp Gly Gly Gly Asp Arg Phe Thr Thr Ala Leu Ala Glu Ala Trp
770 775 780
Val His Gly Ala Ala Val Asp Trp Thr Thr Ile Val Pro Pro Thr Gly
785 790 795 800
Val Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe Asp His Lys Arg Tyr
805 810 815
Trp Leu Leu Pro Lys Pro Thr Gly Gly Asp Gly Ile Gly His Gly Leu
820 825 830
Leu Thr Thr Ala Val Ala Leu Pro Gly Ser Asp Gly Val Leu Ala Thr
835 840 845
Gly Lys Leu Ser Gln Thr Thr His Pro Trp Leu Ala Asp His Ala Val
850 855 860
His Asp Thr Val Leu Leu Pro Gly Thr Ala Phe Leu Glu Leu Val Ile
865 870 875 880
Arg Ala Gly Asp Glu Ala Gly Cys Asp Leu Val Glu Glu Leu Val Ile
885 890 895
Glu Thr Pro Leu Ala Leu Pro Val Thr Gly Ala Val Asp Leu Thr Val
900 905 910
Thr Val Asp Arg Pro Asp Glu Ala Gly Arg Arg Pro Val Thr Val His
915 920 925
Ala Arg Pro Glu Gly Thr Asp Thr Trp Thr Arg His Ala Thr Gly Thr
930 935 940
Leu Thr Arg Ala Gly Ser Thr Met Ala Ala Gly Pro Ser Ala Trp Pro
945 950 955 960
Pro Pro Gly Ala Gln Ala Val Asp Ile Thr Gly Phe Tyr Glu Arg Leu
965 970 975
Ala Thr Ala Gly Tyr Leu Tyr Gly Pro Ala Phe Gln Gly Leu Arg Ala
980 985 990
Ala Trp Arg Asp Gly Asp Thr Leu Tyr Ala Glu Val Thr Leu Pro Gly
995 1000 1005
Glu Gln Glu Asp Asp Ala Ser Arg Tyr Gly Val His Pro Ala Leu
1010 1015 1020
Leu Asp Ala Ala Leu His Val Thr Cys Leu Pro Leu Leu Thr Gly
1025 1030 1035
Gln Glu Ser Asp Pro Gly Glu Val Lys Leu Pro Phe Ser Trp Asn
1040 1045 1050
Gly Val Arg Met His Thr Thr Gly Ala Thr Thr Leu Arg Val Ala
1055 1060 1065
Ile Thr Pro Gly Pro Gly Pro Asn Gly Val Thr Val His Ala Thr
1070 1075 1080
Asp Pro Ala Gly His Pro Val Leu Thr Val Ser Glu Leu Thr Ala
1085 1090 1095
Arg Pro Val Asp Thr Ser Thr Leu Thr Asp Gly Asp Ala Ala Ala
1100 1105 1110
Arg Asn Ser Leu Tyr Asp Leu Ser Trp Thr Glu Leu Pro Pro Pro
1115 1120 1125
Ala Pro Thr Leu Asn Arg Ala Pro Gly Thr Glu Thr Arg Pro Gly
1130 1135 1140
Pro Ala Gly Pro Ala Pro Cys Val Ser Ala Leu Pro Lys Pro Gly
1145 1150 1155
Ala Asp Val Leu Gln Glu Thr Tyr Arg Leu Thr Glu Leu Val Leu
1160 1165 1170
Gly Glu Leu His Arg Val Ile Ala Asp Glu Ser Leu Ala Glu Thr
1175 1180 1185
Thr Pro Leu Val Val Arg Ile Asp Ala Gly Pro Thr Gly Gly Ala
1190 1195 1200
Val Ala Gly Leu Val Arg Ser Ala Gln Ala Glu His Pro Gly Arg
1205 1210 1215
Phe Val Leu Val Glu Thr Gly Ala Asp Thr Pro Asp Glu Ala Val
1220 1225 1230
Ala Ala Ala Val Thr Leu Ala Glu Pro Tyr Val Arg Leu Thr Glu
1235 1240 1245
Gly Arg Tyr Glu Val Pro Arg Leu Thr Arg Thr Ala Ala Pro Ala
1250 1255 1260
Gln Pro Asp Gly Pro Leu Leu Asp Pro Asp Gly Thr Val Val Ile
1265 1270 1275
Thr Gly Gly Ser Gly Val Leu Ala Gly Leu Leu Ala Arg Arg Leu
1280 1285 1290
Val Thr Glu His Gly Ala Arg His Leu Leu Leu Leu Ser Arg Ser
1295 1300 1305
Glu Pro Pro Pro Asp Thr Pro Gly Val His Val Arg Cys Asp Val
1310 1315 1320
Ser Asp Arg Asp Arg Leu Ala Ala Val Leu Ala Ala Val Glu Arg
1325 1330 1335
Pro Leu Thr Ala Val Phe His Thr Ala Ala Val Leu Asp Asp Gly
1340 1345 1350
Val Val Thr Ala Leu Thr Pro Glu Arg Leu Ala Thr Ala Leu Arg
1355 1360 1365
Pro Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Arg Gly
1370 1375 1380
Ala Asp Leu Arg Ala Phe Val Leu Tyr Ser Ser Val Ala Gly Leu
1385 1390 1395
Leu Gly Gly Arg Gly Gln Gly Asn Tyr Ala Ala Ala Asn Gly Phe
1400 1405 1410
Leu Asp Gly Leu Ala Ala Gln Arg Arg Ala Glu Gly Leu Pro Ala
1415 1420 1425
Leu Ser Leu Ala Trp Gly Leu Trp Glu Asp Asp Ser Gly Leu Thr
1430 1435 1440
Gly Ser Met Ser Gly Thr Asn Arg Thr Arg Val Arg Arg Gly Gly
1445 1450 1455
Phe Arg Pro Met Gln Gly Asp Gln Ala Leu Arg Leu Leu Glu Thr
1460 1465 1470
Ala Ala Gly Thr Gly Ala Ala Phe Thr Val Ala Ala Ala Met Asp
1475 1480 1485
Leu Asn Ala Gln Thr Ser Pro Leu Phe Ala Gly Leu Arg Arg Pro
1490 1495 1500
Ala Pro Arg Arg Thr Ala Ala Thr Gly Val Pro Leu Val Glu Arg
1505 1510 1515
Leu Ala Thr Met Ala Arg Thr Asp Arg Asp Ala Ala Leu Leu Thr
1520 1525 1530
Leu Val Arg Asp Cys Ala Ala Ala Val Leu Gly His Ala Asp Ala
1535 1540 1545
Ala Asp Val Pro Ala Asp Ala Ala Phe Lys Asp Leu Gly Val Asp
1550 1555 1560
Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Ala Thr
1565 1570 1575
Gly Val Arg Leu Pro Ala Thr Leu Ala Phe Asp His Pro Thr Pro
1580 1585 1590
Arg Ala Val Ala Ser Arg Leu Asn Asp Thr Leu Thr Gly Ala Ala
1595 1600 1605
Pro Ala Arg Pro Thr Ala Arg Pro Ala Thr Ala Ala Thr Gly Asp
1610 1615 1620
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly
1625 1630 1635
Val Thr Ser Pro Ala Asp Leu Trp Arg Leu Val Asp Ser Gly Gly
1640 1645 1650
Asp Ala Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Pro Thr
1655 1660 1665
Val Leu Gly Gly Arg Ala Asp Ala Asp Arg Gly Gly Phe Leu Ser
1670 1675 1680
Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg
1685 1690 1695
Glu Ala Leu Thr Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr
1700 1705 1710
Ser Trp Glu Ala Phe Glu His Ala Gly Ile Val Pro Lys Thr Leu
1715 1720 1725
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Thr Phe Ser Tyr Gly
1730 1735 1740
Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ser Leu Gly Val
1745 1750 1755
Gln Pro Ser Val Leu Thr Gly Arg Ile Ser Tyr Phe Tyr Gly Phe
1760 1765 1770
Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
1775 1780 1785
Val Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys
1790 1795 1800
Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Gly Thr Pro Asp
1805 1810 1815
Gly Phe Val Glu Phe Glu Gln Gln Gly Gly Leu Ser Pro Asp Gly
1820 1825 1830
Arg Cys Arg Ala Phe Ala Asp Thr Ala Asn Gly Thr Gly Trp Ala
1835 1840 1845
Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Glu
1850 1855 1860
Arg His Gly His Ser Val Leu Ala Val Val Arg Gly Ser Ala Val
1865 1870 1875
Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro
1880 1885 1890
Ala Gln Gln Arg Val Ile Arg Gly Ala Leu Glu Arg Ala Gly Leu
1895 1900 1905
Gly Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr
1910 1915 1920
Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Val Tyr
1925 1930 1935
Gly Gln Gly Arg Glu Val Pro Leu Tyr Leu Gly Ser Leu Lys Ser
1940 1945 1950
Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile
1955 1960 1965
Lys Met Val Met Ala Met Arg Tyr Gly Val Leu Pro Arg Thr Leu
1970 1975 1980
His Val Gly Glu Pro Ser Ser His Val Asp Trp Ser Ala Gly Ser
1985 1990 1995
Val Glu Val Leu Ser Glu Ala Arg Pro Trp Pro Glu Ser Gly Arg
2000 2005 2010
Ala Arg Arg Ala Gly Val Ser Gly Phe Gly Val Ser Gly Thr Asn
2015 2020 2025
Ala His Val Ile Leu Glu Gly Val Pro Glu Val Ser Val Ser Pro
2030 2035 2040
Thr Glu Ser Ser Gly Gly Leu Leu Pro Leu Pro Val Ser Ala Arg
2045 2050 2055
Ser Gly Val Gly Val Gly Val Leu Val Glu Arg Val Gly Gly Leu
2060 2065 2070
Val Gly Gly Gly Cys Asp Val Gly Val Val Ala Asp Gly Leu Val
2075 2080 2085
Arg Gly Arg Ala Val Phe Gly His Arg Ala Val Leu Leu Gly Glu
2090 2095 2100
Ser Arg Val Met Gly Val Ala Gly Glu Gly Leu Arg Thr Val Phe
2105 2110 2115
Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Val Glu
2120 2125 2130
Leu Met Gly Trp Ser Glu Val Phe Ala Arg Arg Met Gly Glu Cys
2135 2140 2145
Ala Ala Ala Leu Lys Pro Phe Thr Gly Trp Asp Leu Gly Glu Val
2150 2155 2160
Leu Ala Gly Arg His Asp Ser Gly Ala Val Glu Val Val Gln Pro
2165 2170 2175
Leu Ser Trp Ala Val Ala Val Ser Leu Ala Gly Leu Trp Gly Ser
2180 2185 2190
His Gly Val Val Pro Asp Val Val Val Gly His Ser Gln Gly Glu
2195 2200 2205
Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Gly
2210 2215 2220
Ala Arg Val Val Ala Leu Arg Ser Arg Val Ile Gly Ala Arg Leu
2225 2230 2235
Ala Gly Arg Gly Val Met Ala Ser Val Ala Leu Pro Ala Ala Asp
2240 2245 2250
Ile Glu Thr Val Glu Gly Val Trp Ile Ala Ala Arg Asn Gly Pro
2255 2260 2265
Ser Ser Thr Val Ile Ala Gly Asp Ala Gln Ala Val Glu Gly Val
2270 2275 2280
Leu Ala Arg Tyr Glu Thr Ala Gly Val Arg Val Arg Arg Ile Ala
2285 2290 2295
Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile Glu Asn
2300 2305 2310
Glu Leu Ala Glu Ala Leu Thr Gly Ile Thr Ala Arg Thr Pro Thr
2315 2320 2325
Ile Pro Trp Trp Ser Thr Val Asp Ser Gly Trp Val Thr Gly Pro
2330 2335 2340
Val Asp Asp Gly Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala
2345 2350 2355
Leu Asp Thr Ala Ile Thr Glu Leu Asp Gly Ser Leu Phe Ile Glu
2360 2365 2370
Cys Ser Ala His Pro Val Leu Leu Pro Ala Ile Asp Gln Glu Arg
2375 2380 2385
Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Gly Gly Asp Arg Phe
2390 2395 2400
Thr Thr Ala Leu Ala Glu Ala Trp Val Gln Gly Ala Ala Val Asp
2405 2410 2415
Trp Thr Thr Val Val Pro Pro Thr Gly Val Arg Leu Leu Asp Leu
2420 2425 2430
Pro Thr Tyr Pro Phe Asp His Lys Arg Tyr Trp Leu Pro Pro Ala
2435 2440 2445
Pro Ala Gly Gly Ser Glu Gly Ile Gly His Pro Phe Leu Ser Ser
2450 2455 2460
Val Val Ala Leu Pro Gly Ser Asp Ser Val Leu Leu Lys Gly Arg
2465 2470 2475
Val Ser Leu Ala Ala His Pro Trp Leu Ala Asp His Thr Val Gln
2480 2485 2490
Asp Thr Val Leu Leu Pro Gly Thr Ala Leu Leu Glu Leu Val Leu
2495 2500 2505
Arg Ala Gly Asp Glu Thr Gly Cys Asp Thr Ile Asp Glu Leu Ile
2510 2515 2520
Ile Glu Thr Pro Leu Ala Leu Pro Val Thr Gly Ala Val Asp Leu
2525 2530 2535
Thr Val Thr Val Asp Arg Pro Asp Glu Ala Gly Arg Arg Pro Val
2540 2545 2550
Thr Val His Ala Arg Pro Glu Gly Thr Asp Thr Trp Thr Arg His
2555 2560 2565
Ala Thr Gly Thr Leu Thr Thr Thr Gly Thr Thr Gly Thr Thr Val
2570 2575 2580
Ala Ala Asp Pro Ser Ala Trp Pro Pro Pro Ala Ala His Ala Val
2585 2590 2595
Asp Ile Thr Gly Phe Tyr Gln Glu Leu Ala Ala Val Gly Tyr Gly
2600 2605 2610
Tyr Gly Pro Ala Phe Cys Gly Leu Arg Ala Ala Trp Arg Asp Gly
2615 2620 2625
Asp Thr Leu Tyr Ala Asp Val Ala Leu Pro Asp Glu Gln Ala Ala
2630 2635 2640
Glu Ala Pro Arg Tyr Gly Met His Pro Ala Leu Leu Asp Ala Ala
2645 2650 2655
Leu Gln Ile Val Ala Leu Thr Ala Pro Asp Gly Ser Thr Ala Asp
2660 2665 2670
Leu Pro Phe Ala Trp Thr Gly Ala Arg Leu Val Ala Val Gly Ala
2675 2680 2685
Ala Ala Leu Arg Val Ala Val Thr Arg Asp Gly Asp Glu Leu Ser
2690 2695 2700
Leu Arg Ala Ala Asp Ser Thr Gly Arg Pro Val Ala Glu Ile Arg
2705 2710 2715
Thr Ile Arg Thr Arg Pro Leu Ser Leu Pro Val Gly Thr Gly Leu
2720 2725 2730
Met Arg Leu Thr Trp Thr Glu Pro Ala Val Pro Ala Asp Val Pro
2735 2740 2745
Met Thr Asp Val Asp Val Ile Thr Leu His Ala Ala Asp Asp Asp
2750 2755 2760
Pro Thr Ala Glu Thr Arg Ala Leu Thr Ala His Leu Leu Glu Ala
2765 2770 2775
Leu Thr Gly Thr Asp Arg Thr Leu Leu Val Gln Thr Thr Glu Gly
2780 2785 2790
Leu Ala Thr Ala Ala Ala Ala Gly Leu Leu Arg Thr Ala Gln Ala
2795 2800 2805
Glu Gln Pro Gly Arg Phe Val His Val Glu Thr Ala Pro Gly Ala
2810 2815 2820
Thr Leu Asp Thr Gly Gln Gln Gln Ile Ala Val Ala Leu Gly Glu
2825 2830 2835
Pro Arg Leu Arg Leu Arg Arg Gly Arg Phe Glu Ala Ala Arg Leu
2840 2845 2850
Thr Arg Val Pro Glu Pro Leu Ala Val Pro Glu Ser Asp Thr Trp
2855 2860 2865
Leu Ile Arg Pro Ala Pro Thr Gly Thr Leu Glu Gly Leu Thr Ala
2870 2875 2880
Val Asp Ser Ala Glu Pro Trp Arg Pro Leu Ala Pro Thr Glu Val
2885 2890 2895
Arg Ile Ala Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu
2900 2905 2910
Ile Ala Leu Gly Thr Tyr Pro Gly Arg Gly Val Leu Gly Gly Glu
2915 2920 2925
Ala Ala Gly Ile Val Leu Glu Thr Gly Pro Asp Val His Asp Leu
2930 2935 2940
Val Pro Gly Asp Arg Val Phe Gly Leu Val Gly Thr Gly Phe Gly
2945 2950 2955
Pro Thr Val Val Ala Asp His Arg Met Leu Gly Arg Ile Pro Glu
2960 2965 2970
Gly Trp Thr Phe Pro Gln Ala Ala Ser Val Val Thr Val Phe Ala
2975 2980 2985
Thr Ala Trp Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Pro Gly
2990 2995 3000
Glu Lys Val Leu Ile His Ala Ala Ala Thr Gly Val Gly Ala Ala
3005 3010 3015
Ala Val Gln Ile Ala Arg His Leu Gly Ala Glu Val Tyr Ala Thr
3020 3025 3030
Ala Ser Ile Ala Lys Gln His Leu Leu Asp Leu Asp Gly Pro His
3035 3040 3045
Thr Ala Asp Ser Arg Ser Thr Ala Phe Ala Thr Thr Phe Pro Pro
3050 3055 3060
Val Asp Val Val Leu Asn Ala Leu Thr Gly Glu Leu Leu Asp Ala
3065 3070 3075
Ser Val Ala Leu Leu Ala Pro Gly Gly Arg Phe Ile Glu Met Gly
3080 3085 3090
Lys Thr Asp Leu Arg His Asp Ile Gln Gln Pro Phe Asp Leu Met
3095 3100 3105
Asp Ala Gly Pro Asp His Leu Gln Gln Ile Ile Thr Arg Leu Leu
3110 3115 3120
Asp Leu Phe Ala Gln Gly Thr Leu His Pro Leu Pro Val Thr Val
3125 3130 3135
His Asp Met Arg Gln Ala His Glu Ala Met Ala Thr Met Ser Arg
3140 3145 3150
Gly Asp His Thr Gly Lys Leu Val Leu Thr Val Pro Arg Pro Leu
3155 3160 3165
Asp Pro Asp Gly Ala Ile Val Ile Thr Gly Gly Ser Gly Thr Leu
3170 3175 3180
Ala Gly Ile Leu Ala Arg His Leu Asp His Pro His Thr Tyr Leu
3185 3190 3195
Leu Ser Arg Thr Pro Pro Pro Pro Thr Thr Pro Gly Thr His Ile
3200 3205 3210
Pro Cys Asp Leu Thr Asp Pro His Gln Leu Thr Gln Ala Leu His
3215 3220 3225
Gln Ile Pro Gln Pro Leu Thr Gly Ile Phe His Thr Ala Ala Thr
3230 3235 3240
Leu Asp Asp Thr Leu Ile Asp His Leu Thr Pro Thr Arg Ile His
3245 3250 3255
Thr Val Leu Gln Pro Lys Ala Asp Ala Ala Trp His Leu His His
3260 3265 3270
His Thr Arg Asn Thr Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser
3275 3280 3285
Ala Ala Gly Val Leu Gly Thr Pro Gly Gln Gly Asn Tyr Ala Ala
3290 3295 3300
Ala Asn Ala Phe Leu Asp Ala Leu Ala Glu His Arg Arg Thr Leu
3305 3310 3315
Gly Leu Pro Ala Leu Ser Ile Ala Trp Gly Leu Trp Asp Gln Ala
3320 3325 3330
Thr Arg Leu Thr Gly Gly Leu Thr Asp Ala Asp Arg Arg Arg Met
3335 3340 3345
Arg Arg Gly Gly Ala Ser Ala Leu Thr Ala Glu Gln Gly Met Arg
3350 3355 3360
Met Tyr Glu Ala Ala Val Arg Ala Gly Thr Gly Ser Val Val Ala
3365 3370 3375
Val Ala Gly Glu Leu Pro Ser Asp Leu Pro Leu Leu Arg Gly Arg
3380 3385 3390
Pro Lys Pro Val Pro Arg Arg Val Thr Arg Asp Glu Asp Pro Thr
3395 3400 3405
Gly Asp Leu Leu Thr Leu Val Arg Gln Lys Ala Ala Ala Leu Leu
3410 3415 3420
Gly His Gly Gly Pro Asp Asp Ile Pro Glu Asp Ala Ala Phe Arg
3425 3430 3435
Glu Leu Gly Val Asp Ser Leu Ile Ala Val Gln Leu Arg Asn Gly
3440 3445 3450
Leu Asn Glu Ala Thr Gly Leu Lys Leu Ala Ala Thr Leu Val Phe
3455 3460 3465
Asp Tyr Pro Thr Pro Arg Ala Leu Ala Gly Arg Ile Gly Glu Leu
3470 3475 3480
Leu Ser Pro Asp Asp Pro Ala Thr Ala Ala Leu Ala Gln Leu Asp
3485 3490 3495
Arg Leu Glu Ala Leu Val Ala Asp Val Asp Pro Gly Asp Arg Arg
3500 3505 3510
Ala Asp Pro Ile Gly Thr Arg Ile Ala Ala Leu Leu Asp Arg Trp
3515 3520 3525
Gln Arg Ala Ala His Pro Ala Ala Pro Ala Gly Val Leu Ser Ala
3530 3535 3540
Glu Ala Thr Ala Asp Glu Ile Phe Asp Leu Ile Asp Arg Glu Leu
3545 3550 3555
Arg
<210> 33
<211> 10680
<212> DNA
<213> Streptomyces sp. GT1005
<400> 33
atggcatgcc gtctgcccgg cggcatcaca tcgccggaag agctgtggga gctcgtcgag 60
gccgggggcg acgcggtcgg ggacttcccc accgaccgcg gttgggacgt ggccgcgctc 120
cacgccgacg ccgagtcggc cacctcacgg gcaggcgccc tcaggggagc cggcgacttc 180
gacgccgcgt tcttcgggat cagcccgcgc gaggccaccg cgctcgaccc gcagcagcgg 240
atccttctgg agatcgcctg ggaggcgctc gaacgcgcgg gcatcgtgcc ggacaccctg 300
cgcggcaccg acacgggcgt cttcgtcggc ggcttctact acggctacgg agcaggcgcc 360
gacctgggcg ggttcggcgc gtacagcaca cagcccgcgg tgctcgccgg acgcctctcc 420
tacttcttcg gactccaggg cccggcggtg acggtcgata cggcgtgctc gtcgtcgctg 480
gtcgccctgc accaggcagg gcaggcactg cgcagcggcg aatgctcgct tgcgctggtc 540
ggcggggtca cggtgatggc gtcgccgcag agcttcgtgg agttctcccg gcagggcggg 600
gtggcctcgg acgggcggtg caaggcgttc gccgatacgg ccgacggcac cggattcgcc 660
gagggagccg gtgttctggt ggtggagcgg ttgtcggatg cggagcgtca tggtcattcg 720
gtgcttgcgg tggtgcgggg ttcggcggtg aatcaggacg gtgcgtcgaa tggtttgtcg 780
gcgccgaatg gtccggcgca gcagcgggtg attcgtgggg cgttggagcg ggcggggttg 840
ggtccggcgg atgtggatgt ggtggaggcg catgggacgg ggacggtgtt gggggatccg 900
attgaggcgc aggcggttat tgcggtgtat gggcaggggc gtgaggtgcc gctgtatttg 960
ggttcgttga agtcgaatat tggtcatgcg caggcggcgg ctggtgtggc tggtgtgatc 1020
aagatggtgt tggcgatgcg gtacggggtg ctgccgagga cgttgcacgt cggtgagccg 1080
tcgtcgcatg tggactggtc ggcgggggcg gtggagctgc tgacggaggc gaggccgtgg 1140
ccggagtcgg ggcgtgcgcg gcgggcgggg gtgtcggggt tcggggtgag tgggacgaat 1200
gcgcatgtgg tgttggaggg ggtgccggag gtttcggttt ctgccgctga gcccgagtcc 1260
ggtggtttgg tgccgttgcc ggtgtcggct cgttcgggtg tgggtgtggg tgtgttggtg 1320
gagcgggtgg gtgggttggt ggggggtggg tgtgatgtgg gtgtggtggc ggatgggttg 1380
gtgcgggggc gtgcggtgtt cggtcatcgg gcggtgctgt tgggggagag cagggttacg 1440
ggtgtggcgg gtgaggggtt gcggacggtg ttcgtgttcc cggggcaggg gtcgcagtgg 1500
gtgggaatgg gtgtggagtt gatggggtgg tcggaggtgt ttgcgcggcg gatgggtgag 1560
tgtgcggcgg cgttgaagcc gttcacgggc tgggatctgg gtgaggtgct ggccgggcgg 1620
cacgattccg gggctgtgga ggtggtgcag ccgttgtcgt gggcggtggc ggtgagtctg 1680
gcggcgctgt ggggggcgca tggtgtggtg ccggatgtgg tggtggggca ttcgcagggg 1740
gagattgctg cggcgtgtgt ggcgggtgcg ctgagcctgg aggacggggc gcgggtggtg 1800
gctttgcgga gccgggtgat cgcgggccgg ctggcggggc ggggggtgat ggcatcggtc 1860
gccctccccg ctgccgacat cgagacggtg gagggggtgt ggatcgcggc ccgtaacggc 1920
ccgtcgtcga ccgtgatcgc gggagatgcg caggcggtgg agggggttct ggcccggtgc 1980
gaaactgcgg gggtacgggt tcggcggatc gcggtcgact acgcctccca caccccccac 2040
gtcgaggcca tcgaggacga actggccgag gtgctggaag gcgtaaccac ccgtactcct 2100
gtgatccctt ggtggtccac ggtcgacagc ggctgggtgg aggagccggt cgacgacggc 2160
tactggtacc gcaacctccg tcaaccggta gccctggaca ccgccatcac agaactcgac 2220
ggctccctct tcatcgagtg cagtgcgcac ccggtgctgc tgcccgccat cgaccagcaa 2280
cgtaccgtcg cctccctgcg taccgacgac ggcggcggag accggttcac caccgccctg 2340
gccgaagcct gggtccacgg cgcggccgtc gactggacca ccatcgtccc gcccaccggg 2400
gtacggctcc tcgacctccc cacctacccc ttcgaccaca agcgctactg gctgttgccc 2460
aagccgaccg gcggcgacgg tatcgggcac gggctgctga cgaccgccgt ggcgctgccg 2520
ggcagcgacg gggtgttggc gacagggaag ctgtcgcaga ccacgcatcc ctggctggcc 2580
gaccacgccg tccacgacac ggtactgctg ccgggtaccg cgttcctgga gctggtgatc 2640
cgcgccggtg acgaggcggg ctgcgacctg gtcgaggaac tggtcatcga gacaccgctc 2700
gcccttccgg tcaccggagc cgtcgacctc accgtcaccg tcgaccggcc cgacgaggcc 2760
ggacgccgcc cggtgaccgt ccacgcccgc cccgaaggaa ccgacacctg gacccgccac 2820
gccaccggaa ccctcacccg cgccggaagc acaatggcgg cgggcccgtc cgcgtggccg 2880
ccaccgggag cccaagccgt cgacatcacc ggcttctacg agcggctcgc gacagcgggc 2940
tacctctacg gcccggcctt ccagggcctg cgcgcggcct ggcgcgacgg cgacaccctc 3000
tacgccgagg tgacgctccc cggagaacag gaggacgacg catcccggta cggcgtacac 3060
ccggccctgc tcgacgccgc gctgcacgtc acctgtctgc ccctgctcac agggcaggaa 3120
tcggatccgg gagaggtgaa gctgccgttc tcgtggaacg gcgtgcggat gcacacgacc 3180
ggtgccacca cgctccgcgt cgcgatcacc ccgggcccgg gcccgaacgg tgtgaccgtg 3240
cacgcgacgg acccggccgg tcacccggta ctgaccgtct ccgaactgac cgcacgaccg 3300
gtcgacacca gcacactcac cgacggcgac gccgcggccc gcaactccct gtacgacctc 3360
tcctggaccg agctgccgcc ccccgcgccc accctgaacc gtgcacccgg gacggagacc 3420
cgccccgggc ccgcgggccc ggccccctgt gtctcggcgc tcccgaagcc gggcgcggat 3480
gtgctccagg agacgtaccg gctcaccgaa ctggtgctcg gtgagctgca ccgggtgatc 3540
gccgacgaaa gcctcgcgga gacgaccccc ctggtcgtcc gcatcgacgc gggaccgacc 3600
gggggagcgg tcgccggtct cgtccgctcc gcacaggccg agcaccccgg acgcttcgtg 3660
ctggtggaga ccggcgccga caccccggac gaggcagtgg ccgcggccgt gacactggcc 3720
gaaccgtacg tccgtctcac cgagggccgg tacgaagtgc cccggctcac ccgcaccgca 3780
gcgcccgcgc agccggacgg gccactgctg gaccccgacg gcacggtggt catcaccggc 3840
ggctcgggcg tactggcggg ccttctcgcc cggcgcctcg tcaccgaaca cggcgcccgc 3900
cacctcctgc tcctctcccg cagcgaaccg ccaccggaca cacccggtgt tcacgtccgc 3960
tgcgacgtct ccgaccggga ccggctcgcc gccgtactcg ccgccgtgga gcggccgctg 4020
accgccgtct tccacacggc ggcggtgctc gacgacggcg tggtcaccgc gctcaccccg 4080
gaacggctcg ccaccgcgct gcgacccaag gccgacggcg cctggcatct ccacgagctg 4140
acccgcggcg cggacctgcg cgcattcgtc ctctactcgt ccgtcgcggg ccttctgggc 4200
ggccgcggcc agggcaacta cgccgcggcc aacggcttcc tcgacggact cgccgcccag 4260
cgccgggccg aagggctgcc cgcgctgtcg ctggcctggg gtctctggga ggacgacagc 4320
ggactcaccg gcagtatgag cggcaccaac cggacccgcg tgcgccgcgg cggattccgc 4380
cccatgcagg gcgaccaggc gctacgcctg ctggagaccg ccgccggaac cggtgccgcg 4440
ttcaccgtgg cggccgccat ggacctgaac gcgcagacct cgccgctctt cgccggcctg 4500
cggcgccccg cgccacgccg gacggccgcc accggtgttc cgcttgtcga acggctcgcg 4560
accatggccc gcaccgaccg ggacgccgcg ctgctcaccc tggtccgcga ctgcgcggcg 4620
gccgtgctcg gccacgcgga cgccgcggac gtgcccgcgg atgcggcgtt caaggatctc 4680
ggggtcgact cgctgaccgc cgtcgaacta cggaaccggc tcgccgcggc gaccggtgtc 4740
cggctgcccg ccaccctcgc cttcgaccat ccgacgccgc gggccgttgc gtcccggctc 4800
aacgacacgc tgaccggcgc cgcccccgcc cggccgaccg cacggcccgc caccgcggcg 4860
accggtgacg agcccctcgc gatcgtcggc atggcctgcc gtctccccgg cggcgtcaca 4920
tcacccgcag acctgtggcg gctggtggac agcggcggcg atgcgatcag cggcttcccc 4980
gtcgaccgcg gctgggaccc gaccgtcctg ggcggcaggg cggacgcgga ccggggcggc 5040
ttcctctccg acgccgcgga cttcgacgcc gcgttcttcg ggatcagccc gcgcgaggca 5100
ctgacgatgg acccgcaaca gcgtctggtc ctggagacgt catgggaggc gttcgagcac 5160
gcgggcatcg tgccgaaaac gctccggggg agcgacaccg gcgtgttcat gggtaccttc 5220
tcgtacggct acggagcagg cgccgacctg ggcggattcg gctccctggg cgtacagccc 5280
agcgtcctca ccggccgtat ctcgtacttc tacggcttcc agggcccggc ggtgacggtc 5340
gatacggcgt gttcgtcgtc gctggtcgcc ctgcaccagg cagggcacgc cctgcgccaa 5400
ggggagtgct cgctggcgct ggtcggcggg gtcacggtga tgggcacccc ggacgggttc 5460
gtcgagttcg agcaacaggg cggactctct cccgacggcc gctgccgagc gttcgcggac 5520
accgcgaacg gcaccggctg ggcggaaggc gtcggtgttc tggtggtgga gcggttgtcg 5580
gatgcggagc gtcatggtca ttcggtgctt gcggtggtgc ggggttcggc ggtgaatcag 5640
gacggtgcgt cgaatgggtt gtcggcgccg aatggtccgg cgcagcagcg ggtgattcgt 5700
ggggcgttgg agcgggcggg gttgggtcct gcggatgtgg atgtggtgga ggcgcatggg 5760
acggggacgg tgctggggga tccgattgag gcgcaggcgg ttattgcggt gtatgggcag 5820
gggcgtgagg tgcctctgta tttgggttcg ttgaagtcga atattggtca tgcgcaggcg 5880
gcggctggtg tggccggtgt gatcaagatg gtgatggcga tgcggtacgg ggtgttgccg 5940
aggacgttgc acgtcggtga gccgtcgtcg catgtggact ggtcggcggg gtcggtggag 6000
gtgttgtcgg aggcgaggcc gtggccggag tcggggcgtg cgcggcgggc gggggtgtcg 6060
gggttcgggg tgagcgggac gaatgcgcat gtgattttgg agggggtgcc ggaggtttcg 6120
gtctctccca cagagtcgtc cggtggtttg ttgccgttgc cggtgtcggc tcgttcgggt 6180
gtgggtgtgg gtgtgttggt ggagcgggtg ggtgggttgg tggggggtgg gtgtgatgtg 6240
ggggtggtgg cggatgggtt ggtgcggggg cgtgcggtgt tcggtcatcg ggcggtgctg 6300
ttgggggaga gcagggttat gggtgtggcg ggtgaggggt tgcggacggt gttcgtgttc 6360
ccggggcagg ggtcgcagtg ggtgggaatg ggtgtggagt tgatggggtg gtcggaggtg 6420
ttcgcccggc ggatgggtga gtgtgcggcg gcgttgaagc cgttcacggg ctgggatctg 6480
ggtgaggtgc tggccgggcg gcacgattcc ggggctgtgg aggtggtgca gccgttgtcg 6540
tgggcggtgg cggtgagtct ggccgggttg tgggggtcgc atggtgtggt gccggatgtg 6600
gtggtggggc attcgcaggg ggagattgct gcggcgtgtg tggcgggtgc gctgagcctg 6660
gaggacggag cgcgggtggt ggctttgcgg agccgggtga tcggtgcccg gctggcgggg 6720
cggggggtga tggcatcggt cgcactcccc gccgccgaca tcgagacggt ggagggggtg 6780
tggatcgcgg cccgtaacgg cccgtcgtcg accgtgatcg cgggagatgc gcaggcggtg 6840
gagggggtcc tggcccggta cgaaactgcg ggggtacggg ttcggcggat cgcggtcgac 6900
tacgcctccc acacccccca cgtcgaggcc atcgagaacg aactggccga agcattaacc 6960
ggtattacgg cccggacccc caccatcccc tggtggtcca ccgtcgacag cggctgggtc 7020
accggaccgg tcgacgacgg ctactggtac cgcaacctcc gtcaaccggt agccctggac 7080
accgccatca cagaactcga cggctccctt ttcatcgagt gcagcgccca tcccgtgctg 7140
ctgcccgcca tcgaccagga gcgtaccgtc gcctccctgc gcaccgacga cggcggcgga 7200
gaccggttca ccaccgccct ggccgaagcc tgggttcagg gcgcggccgt cgactggacg 7260
accgtcgtcc cgcccaccgg ggtacggctc ctcgacctcc ccacctaccc cttcgaccac 7320
aagcgctact ggctgcctcc cgccccggca ggcggcagcg agggcatcgg gcatccgttc 7380
ctgtcgagcg tggtggccct gccgggcagc gacagcgtcc tgctgaaggg cagggtgtca 7440
ctcgccgcgc acccctggct ggccgaccac acggtccagg acacggtact tctcccgggc 7500
acggcactac tcgaactcgt gctgagggcc ggtgacgaga ccggctgcga caccatcgac 7560
gagctgatca tcgaaacacc gctcgccctg cccgtcaccg gagccgtcga cctcaccgtc 7620
accgtcgacc ggcccgacga ggccggacgc cgccccgtga ccgtccacgc acgccccgaa 7680
ggaaccgaca cctggacccg ccacgccacc ggaaccctca ccaccaccgg taccaccggt 7740
accaccgtgg cggcggaccc gtccgcgtgg ccgccaccgg cagcgcacgc cgtcgacatc 7800
accggcttct accaggaact cgccgcagtc ggttacggct acggcccggc cttctgcggc 7860
ctgcgcgcgg cctggcgcga cggcgacacc ctctacgcgg atgtcgccct tcccgacgaa 7920
caggctgccg aggcaccccg ctacggcatg caccccgccc tgctcgacgc ggccctgcag 7980
atcgtcgccc tgaccgcgcc ggacggcagc accgccgacc tgccgttcgc ctggaccgga 8040
gcccggctgg tcgccgtcgg cgcagccgcg ctccgggtcg cggtcacccg ggacggggac 8100
gagctgagcc tgcgggccgc cgactccacc ggacgaccgg tcgccgaaat ccggacgatc 8160
cgcacccgtc cgctgtccct gcccgtgggc accggcctca tgcgactgac ctggaccgag 8220
cccgccgtac ccgcggacgt ccccatgacc gatgtggacg tcatcacctt gcacgccgcc 8280
gacgacgacc cgacggccga gacacgtgcg ttgacggccc acctgctgga ggccctgacc 8340
ggcaccgacc gcaccctgct cgtgcagacc accgaggggc tcgccaccgc cgcggccgca 8400
ggcctcctcc gtaccgccca ggccgaacag cccgggcgct tcgtccacgt cgaaaccgca 8460
cccggcgcaa cactcgatac cgggcagcag cagatcgccg tcgccctggg cgaaccgcga 8520
ctccgcctgc gccgcggccg cttcgaggcg gcccgcctca ccagggtgcc ggagccgctc 8580
gccgtcccgg aaagcgacac ctggctgatc cggccggcgc cgaccggcac cctcgaagga 8640
ctcactgccg tcgattcggc agaaccgtgg cggccgctgg cccccaccga ggtccggatc 8700
gcagtccgcg cggcaggtct caacttccgc gacgtgctaa tcgcgctcgg tacctacccc 8760
ggccggggcg tgctcggcgg cgaggccgcg gggatcgtcc tggagaccgg ccccgatgtg 8820
cacgatctgg tacccggcga ccgggtcttc ggtctggtcg gaaccggctt cggccccacg 8880
gtcgtcgccg atcaccggat gctgggccgg ataccggagg gatggacgtt tccgcaggcg 8940
gcgtccgtgg tcaccgtgtt cgcgacggcg tggtacggcc tggtggatct ggcggggctg 9000
cggcccggtg agaaggtcct gatccacgcg gcggccaccg gtgtgggcgc ggcagccgtc 9060
cagatcgccc ggcatctggg cgccgaggtc tacgccaccg cctccatagc gaagcagcat 9120
ctcctggacc tcgacggccc gcacaccgcc gactcccgca gcaccgcgtt cgccaccacc 9180
ttcccccccg tcgacgtcgt actcaacgcc ctcaccggcg aactcctcga cgcctccgtc 9240
gccctcctcg cacccggcgg ccgcttcatc gagatgggca aaaccgacct ccgccacgac 9300
atccagcagc ccttcgacct catggacgcc ggacccgacc acctccagca gatcatcacc 9360
cgactcctcg acctcttcgc ccaaggcacc ctccaccccc tccccgtgac cgttcacgac 9420
atgcggcagg ctcacgaggc gatggcgacc atgagccggg gcgaccacac cgggaagctg 9480
gtgctcacgg tgccgcggcc gctcgacccc gacggcgcga tcgtcatcac cggcggctcc 9540
ggcaccctcg ccggaatcct cgcccgccac ctcgaccacc cccacaccta cctcctctcc 9600
cgaacaccac cgccccccac cacccccggc acccacatcc cctgcgacct caccgacccc 9660
caccaactca cccaagccct ccaccagata ccccaacccc tcaccggcat cttccacacc 9720
gcggccaccc tcgacgacac cctcatcgac cacctcacac ccacccgcat ccacaccgtc 9780
ctccagccca aagccgacgc cgcctggcac ctccaccacc acacccgcaa caccgacctc 9840
gccgcattcg tcctctattc gtcggcggcg ggcgtgctcg ggactcccgg gcagggcaac 9900
tacgccgcgg ccaacgcctt tctcgacgcg ctcgccgaac accgccgcac tctggggctg 9960
ccggcgctgt ccatcgcctg gggcctctgg gaccaggcga cccgtctgac cggcgggctg 10020
accgacgccg accggcgccg catgcgccgg ggaggggcga gcgcactcac cgcggagcag 10080
ggcatgcgca tgtacgaggc agccgttcgg gcgggcacgg gcagtgtcgt cgccgtggcc 10140
ggtgaactcc cctcggatct gccactgctg cgcggacgcc ccaagccggt gccccgccgg 10200
gtcacccgcg acgaggaccc cacgggcgat ctgctcacgc tcgtacggca gaaggccgca 10260
gccctgctgg gacacggagg gccggacgac atccccgagg acgcggcctt ccgggagctc 10320
ggcgtcgact ccctcatcgc ggtccaactc cgcaacggcc tcaacgaagc gaccggtctg 10380
aagctcgccg ccaccctcgt cttcgactac ccgacgcccc gcgcgctggc cggccgcatc 10440
ggcgaactcc tctccccgga cgacccggcg accgccgcac tcgcacagct cgaccggctg 10500
gaggcgctgg tcgcagacgt cgacccgggc gaccgcagag ccgatccgat cgggacccga 10560
atcgccgccc tgctcgaccg ctggcagcgc gcggcccacc cggccgcacc ggccggcgtg 10620
ctgtccgcgg aggcgaccgc ggacgagatc ttcgacctga tcgaccggga gctgcgatga 10680
<210> 34
<211> 7646
<212> PRT
<213> Streptomyces sp. GT1005
<400> 34
Val His Glu Leu Leu Arg Val Asn Ala Glu Arg Gln Gly Asp Arg Ile
1 5 10 15
Ala Tyr Val Asp Ser Arg Arg Ala Val Thr Tyr Ala Gln Leu Arg Leu
20 25 30
Arg Thr Gly Arg Ile Ala Gly His Leu Ala Ala Ala Gly Val Gly Arg
35 40 45
Gly Asp Arg Ile Ala Leu Leu Leu Gly Asn Arg Val Glu Thr Ile Glu
50 55 60
Thr Tyr Ile Ala Ala Ala Arg Ala Ala Ala Val Ala Val Pro Leu Asn
65 70 75 80
Pro Asp Ala Gly Asp Ala Glu Ile Ala His Phe Leu Thr Asp Ser Gly
85 90 95
Ala Thr Val Leu Val Thr Asp Asp Leu His Leu Asp Gln Val Arg Arg
100 105 110
Val Gly Thr Asp Ala Thr Val Val Leu Ala Gly Arg Arg Asp Pro Gly
115 120 125
Cys Thr Ala Tyr Glu Asp Leu Ala Gly Thr Glu Pro Ala Tyr Pro Pro
130 135 140
Arg Asp Asp Leu Ala Leu Asp Glu Pro Ala Trp Met Leu Tyr Thr Ser
145 150 155 160
Gly Thr Thr Gly Arg Pro Lys Gly Val Val Ser Ala Gln Arg Ser Gly
165 170 175
Leu Trp Ser Ala Leu Tyr Cys Asp Val Pro Ser Trp Glu Leu Thr Glu
180 185 190
Thr Asp Glu Leu Leu Trp Pro Ala Pro Leu Phe His Ser Leu Gly His
195 200 205
His Leu Cys Leu Leu Ala Val Leu Thr Val Gly Ala Ser Ala Arg Ile
210 215 220
Leu Gly Gly Phe Val Ala Arg Asp Val Leu Asp Ala Leu Ala Glu His
225 230 235 240
Pro Ser Thr Val Leu Val Gly Val Pro Thr Met Tyr Arg Tyr Leu Leu
245 250 255
Gly Ala Val Ser Gly Glu Pro Glu Ala Gly Ala Leu Arg Ala Ala Leu
260 265 270
Val Ala Gly Ser Thr Ala Pro Ala Ser Leu Thr Ala Asp Phe Glu Ala
275 280 285
Ala Phe Gly Val Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr
290 295 300
Gly Ser Leu Thr Ala Asn Thr Leu Thr Gly Pro Arg Val Pro Gly Ser
305 310 315 320
Cys Gly Leu Pro Val Pro Gly Leu Ser Leu Arg Phe Val Asp Pro Val
325 330 335
Ser Gly Ala Asp Val Pro Arg Gly Asp Glu Gly Glu Leu Trp Ala Ser
340 345 350
Gly Pro Ser Leu Met Leu Gly Tyr His Glu Gln Pro Glu Ala Thr Ala
355 360 365
Glu Val Leu Val Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Gln
370 375 380
Ala Glu Thr Gly His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Val
385 390 395 400
Ile Arg Gly Gly Glu Asn Ile His Pro Gly Glu Ile Glu Ser Val Ala
405 410 415
Gln Ala Val Pro Gly Val Arg Asp Ala Ala Ala Ala Gly Arg Pro His
420 425 430
Pro Val Leu Gly Glu Ile Pro Val Leu Tyr Val Val Pro Glu Gly Pro
435 440 445
Thr Val Pro Thr Asp Ala Ile Leu Ala Glu Cys Arg Arg Gln Leu Ala
450 455 460
Tyr Phe Lys Val Pro Asp Glu Ile Leu Gln Thr Thr Glu Ile Pro Arg
465 470 475 480
Thr Ala Ser Gly Lys Val Arg Arg Gly Glu Leu Ala Gly Arg Thr Thr
485 490 495
Arg Leu Val Ala Thr Gly Ser Gly Glu Thr Ala Leu Cys Glu Leu Val
500 505 510
Trp Glu Arg Arg Glu Leu Pro Thr Thr Val Thr Pro Val Pro Thr Val
515 520 525
Ile Thr Arg Arg Ala Val Gly Ile Asp Pro Ala Glu Val Pro Asp Ala
530 535 540
Asp Gln Ala Ala Leu Trp Asp Glu Ala Leu Lys Asp Gln Ala Ala Asp
545 550 555 560
Pro Gly Ser Phe Val Leu Val Asp Thr Asp Gly Glu Pro Thr Gly Gly
565 570 575
Glu Thr Thr Gly Arg Glu Thr Thr Gly Gly Arg Thr Thr Gly Gly Glu
580 585 590
Thr Thr Gly Gly Glu Thr Thr Asp Gly Glu Thr Thr Asp Gly Glu Ala
595 600 605
Ala Asp Ala Gly Ala Ala Gly Ala Gly Ser Ile Ala Ala Ala Ala Ser
610 615 620
Leu Gly Glu Pro Leu Val Ala Leu Arg Asn Gly Thr Ala Tyr Val Pro
625 630 635 640
Arg Leu Val His Ala Val Thr Thr Pro Leu Pro Pro Gly Pro Trp Ala
645 650 655
Leu Arg Pro Pro Ala Ser Gly Thr Leu Arg Asp Leu Ala Val Ala Pro
660 665 670
Ser Asp Ala Pro Pro His Pro Leu Ala Thr Gly Glu Val Arg Ile Glu
675 680 685
Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu Gly
690 695 700
Thr Tyr Pro Gly Asp Gly Glu Met Gly Gly Glu Ala Ala Gly Ile Val
705 710 715 720
Thr Glu Val Gly Pro Gly Val Asp Asp Leu Thr Pro Gly Asp Arg Val
725 730 735
Phe Gly Leu Val Gln Asp Ala Phe Arg Arg Ser Val Val Ala Asp Arg
740 745 750
Arg Leu Ile Ala Pro Val Pro Gln Gly Trp Ser Phe Pro Val Ala Ala
755 760 765
Ser Val Pro Val Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Ala
770 775 780
Gly Gly Leu Arg Pro Gly Arg Lys Val Leu Ile His Ala Ala Thr Gly
785 790 795 800
Gly Val Gly Met Ala Ala Thr Arg Ile Ala Arg His Leu Gly Ala Glu
805 810 815
Val Tyr Ala Thr Ala Ser Pro Ala Lys Gln His Leu Leu Tyr Ala Asp
820 825 830
Gly Phe Asp Ala Asp His Val Ala Asp Ser Arg Thr Thr Ala Phe Ala
835 840 845
Asp Ala Phe Pro Pro Met Asp Val Val Leu Asn Ser Leu Thr Gly Glu
850 855 860
Leu Leu Asp Ala Ser Val Ala Leu Leu Ala Pro Asp Gly Arg Phe Ile
865 870 875 880
Glu Met Gly Lys Thr Asp Ile Arg His Asp Ala Gln Glu Pro Phe Asp
885 890 895
Leu Ser Asp Ile Ala Pro Ala Arg Leu Arg Glu Ile Leu Glu Leu Leu
900 905 910
Leu Glu Leu Phe Asp Arg Gly Glu Leu Ser Pro Leu Pro Leu Arg Ala
915 920 925
Trp Asp Ile Arg Arg Ala Arg Asp Ala Phe Thr Trp Met Ser Arg Ala
930 935 940
Arg His Thr Gly Lys Met Val Leu Thr Val Pro Gln Pro Leu Gly Pro
945 950 955 960
Asp Thr Pro Val Leu Val Thr Gly Glu Gly Ala Asp Ala Val Ala Gly
965 970 975
Leu Leu Arg Arg Glu Val Asp Ser Gly Pro Val Phe Thr Gly Asp Ala
980 985 990
Asp Ala Leu Ala Thr Ala Asp Ala Val Asp Thr Ser Ala Leu Val His
995 1000 1005
Ile Val Leu Gly Asp Pro Ala Gly Ala Asp Ala Tyr Ala Arg Ser
1010 1015 1020
Arg Ala Ser Glu Gly Leu Pro Ala Val Thr Leu His Gly Leu Pro
1025 1030 1035
Gly Ile Glu Glu Ala Ala Leu Thr Ala Glu Leu Ile Glu Arg Ala
1040 1045 1050
Val Ala Gly Gly Gly Ser Tyr Val Val Thr Arg Val Gly Ser Ala
1055 1060 1065
Gly Ala Arg Ala Glu Ala Met Ala Gly Ala Thr Pro Pro Ile Leu
1070 1075 1080
Ser Arg Leu Ala Gly Arg Ala Gly Pro Ala Asp Pro Asp Gly Pro
1085 1090 1095
Gly Ala Val Asp Pro Ala Trp Ala Asn Arg Leu Ala Ala Ala Ala
1100 1105 1110
Ala Asp Arg Gln Asp Ile Leu Leu Asp Leu Val Arg Asp Thr Val
1115 1120 1125
Ala Thr Val Leu Gly Leu Ser Asn Ala Glu His Cys Ala Pro Asp
1130 1135 1140
Arg Thr Phe Arg Glu Asn Gly Leu Asp Ser Leu Thr Thr Val Glu
1145 1150 1155
Phe Ala Asn Ile Val Ala Ala Arg Thr Gly Leu Arg Val Pro Ala
1160 1165 1170
Ser Thr Ala Phe Asp His Pro Thr Pro Arg Ala Phe Ala Ala His
1175 1180 1185
Leu Ala Gly Ala Thr Thr Ala Ala Pro Ala Pro Ala Arg Thr Val
1190 1195 1200
Gly Pro Gly Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu
1205 1210 1215
Pro Gly Gly Val Ala Ser Pro Glu Glu Leu Trp Arg Leu Val Glu
1220 1225 1230
Ser Gly Gly Asp Ala Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp
1235 1240 1245
Glu Val Glu Ser Leu Tyr Asp Pro Asp Pro Asp Ala Ala Gly Arg
1250 1255 1260
Ser Thr Thr Arg His Gly Gly Phe Leu Thr Gly Ala Thr Gly Phe
1265 1270 1275
Asp Thr Ala Phe Phe Gly Ile Ser Pro Asn Glu Ala Leu Ala Met
1280 1285 1290
Asp Pro Gln Gln Arg Leu Val Leu Glu Thr Ser Trp Glu Ala Phe
1295 1300 1305
Glu His Ala Gly Ile Val Pro Asp Thr Leu Arg Asp Ser Asp Thr
1310 1315 1320
Gly Val Phe Met Gly Ala Phe His Gln Gly Tyr Gly Ala Gly Arg
1325 1330 1335
Asp Leu Gly Gly Leu Gly Val Thr Ala Ile Gln Thr Ser Val Leu
1340 1345 1350
Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe Gln Gly Pro Ala Val
1355 1360 1365
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
1370 1375 1380
Ala Val Gln Ala Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Thr
1385 1390 1395
Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe
1400 1405 1410
Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe
1415 1420 1425
Ala Asp Thr Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val
1430 1435 1440
Leu Val Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr
1445 1450 1455
Val Leu Ala Val Ile Arg Gly Thr Ala Val Asn Gln Asp Gly Ala
1460 1465 1470
Ser Asn Gly Leu Ser Ala Pro Asn Gly Val Ala Gln Gln Arg Val
1475 1480 1485
Ile Arg Gln Ala Leu Ala Ser Ala Gly Leu Ser Gly Ser Asp Val
1490 1495 1500
Gln Ala Val Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp Pro
1505 1510 1515
Ile Glu Ala Gln Ala Val Ile Ala Val Tyr Gly Gln Gly Arg Glu
1520 1525 1530
Val Pro Leu Tyr Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala
1535 1540 1545
Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala
1550 1555 1560
Met Arg Tyr Gly Val Leu Pro Arg Thr Leu His Val Gly Glu Arg
1565 1570 1575
Ser Ser His Val Asp Trp Ser Ala Gly Ala Val Glu Val Leu Ser
1580 1585 1590
Glu Ala Arg Pro Trp Pro Glu Leu Gly Arg Ala Arg Arg Ala Gly
1595 1600 1605
Val Ser Gly Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu
1610 1615 1620
Glu Gly Val Pro Glu Val Ser Val Ser Pro Thr Glu Ser Ser Gly
1625 1630 1635
Gly Leu Leu Pro Leu Pro Val Ser Ala Arg Ser Gly Val Gly Val
1640 1645 1650
Gly Val Leu Val Glu Arg Val Gly Gly Leu Val Gly Gly Gly Cys
1655 1660 1665
Asp Val Gly Val Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val
1670 1675 1680
Phe Gly His Arg Ala Val Leu Leu Gly Glu Ser Arg Val Met Gly
1685 1690 1695
Val Ala Gly Glu Gly Leu Arg Thr Val Phe Val Phe Pro Gly Gln
1700 1705 1710
Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu Ala Glu Val Ser
1715 1720 1725
Pro Val Phe Ala Ala Arg Met Gly Glu Cys Ala Ala Ala Leu Ala
1730 1735 1740
Pro His Val Asp Trp Ser Trp Glu Glu Ala Leu Gly Ser Ala Glu
1745 1750 1755
Leu Leu Gly Arg Val Glu Val Val Gln Pro Leu Ser Trp Ala Val
1760 1765 1770
Ala Val Ser Leu Ala Ala Leu Trp Gly Ala His Gly Val Val Pro
1775 1780 1785
Asp Val Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
1790 1795 1800
Val Ala Gly Ala Leu Ser Leu Glu Asp Gly Ala Arg Val Val Ala
1805 1810 1815
Leu Arg Ser Arg Val Ile Gly Ala Arg Leu Ala Gly Arg Gly Val
1820 1825 1830
Met Ala Ser Val Ala Leu Pro Ala Ala Asp Ile Glu Thr Val Glu
1835 1840 1845
Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ser Ser Thr Val Ile
1850 1855 1860
Ala Gly Asp Ala Gln Ala Val Glu Gly Val Leu Ala Arg Tyr Glu
1865 1870 1875
Ser Thr Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser
1880 1885 1890
His Thr Pro His Val Glu Ala Ile Glu Asp Glu Leu Ala Glu Val
1895 1900 1905
Leu Glu Gly Val Thr Thr Arg Thr Pro Val Ile Pro Trp Trp Ser
1910 1915 1920
Thr Val Asp Ser Gly Trp Val Glu Glu Pro Val Asp Asp Gly Tyr
1925 1930 1935
Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Leu Asp Thr Ala Ile
1940 1945 1950
Thr Glu Leu Asp Gly Ser Leu Phe Val Glu Cys Ser Ala His Pro
1955 1960 1965
Val Leu Leu Pro Ala Ile Asp Gln Gln Arg Thr Val Ala Ser Leu
1970 1975 1980
Arg Thr Asp Asp Gly Gly Gly Asp Arg Phe Thr Thr Ala Leu Ala
1985 1990 1995
Glu Ala Trp Val His Gly Ala Ala Val Asp Trp Thr Thr Ile Val
2000 2005 2010
Pro Pro Thr Pro Glu Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe
2015 2020 2025
Asp His Lys Arg Tyr Trp Leu Pro Pro Ala Pro Ala Gly Gly Ser
2030 2035 2040
Glu Gly Ile Gly His Pro Phe Leu Ser Ser Val Val Ala Leu Pro
2045 2050 2055
Gly Ser Asp Gly Val Leu Leu Lys Gly Arg Val Ser Leu Ala Ala
2060 2065 2070
His Pro Trp Leu Ala Asp His Ala Val Arg Asp Thr Val Leu Leu
2075 2080 2085
Pro Gly Thr Ala Phe Leu Glu Leu Val Ile Arg Ala Gly Asp Glu
2090 2095 2100
Thr Gly Cys Asp Thr Ile Asp Glu Leu Val Ile Glu Thr Pro Leu
2105 2110 2115
Ala Leu Pro Val Thr Gly Ala Val Asp Leu Thr Val Thr Val Asp
2120 2125 2130
Arg Pro Asp Glu Ala Gly Arg Arg Pro Val Thr Val His Ala Arg
2135 2140 2145
Leu Gln Gly Thr Gly Thr Trp Thr Arg His Ala Thr Gly Thr Leu
2150 2155 2160
Thr Thr Gly Thr Lys Arg Thr Thr Asp Ala Pro Asp Pro Tyr Thr
2165 2170 2175
Leu Ala Gln Trp Pro Pro Ala Gly Ala Gln Pro Ala Ser Leu Asp
2180 2185 2190
Arg Phe Tyr Glu Gln Leu Ala Ala Ala Gly Tyr Thr Tyr Gly Pro
2195 2200 2205
Ala Phe Gln Gly Leu Arg Ala Ala Trp Thr Ala Gly Asp Thr Ile
2210 2215 2220
Tyr Ala Glu Ala Ala Leu Asp Ser Ala Glu Glu Val Asp Arg Phe
2225 2230 2235
Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu His Ala Gly Arg
2240 2245 2250
Leu Asp Ala Gly Asp Ala Leu Glu Leu Pro Phe Ser Trp Thr Gly
2255 2260 2265
Val Arg Leu His Ala Gly Gly Ala Thr Ala Val Arg Val Ala Leu
2270 2275 2280
Ile Arg Gly Pro Gly Gly Val Thr Val Gln Met Ala Asp Pro Asp
2285 2290 2295
Gly Arg Pro Val Val Thr Val Asp Ala Leu Val Leu Arg Pro Gly
2300 2305 2310
Thr Gly Thr Pro Ser Gly Pro Lys Leu Leu Gly Leu Glu Trp Val
2315 2320 2325
Pro Val Ala Glu Ala Val Tyr Asp Gly Thr Leu Pro Asp Gly Tyr
2330 2335 2340
Thr Leu Ile Thr Ala Ala His Pro Asp Glu Pro Asp Asp Leu Thr
2345 2350 2355
Asp Leu Thr Asp Met Pro Ala Leu Thr Gln Ala Arg Thr Thr Arg
2360 2365 2370
Thr Leu Thr Ala Leu Gln His His Leu Thr Thr Thr His His Thr
2375 2380 2385
Leu Ile Val His Thr Thr Thr Asp Pro Ala Gly Ala Ala Ala Thr
2390 2395 2400
Gly Leu Thr Lys Thr Ala Gln Asn Glu His Pro Asn Arg Ile His
2405 2410 2415
Ile Ile Glu Thr Thr His Pro His Thr Pro Leu Pro Leu His Gln
2420 2425 2430
Ile Thr Thr Leu Asn Gln Pro His Leu Arg Leu Thr His His Thr
2435 2440 2445
Leu His Thr Pro His Leu Thr Pro Leu His His Thr Pro Thr Pro
2450 2455 2460
Thr Pro Pro Leu Asn Pro His His Ala Ile Leu Ile Thr Gly Gly
2465 2470 2475
Ser Gly Thr Leu Ala Gly Ile Leu Ala Arg His Leu Asn His Pro
2480 2485 2490
His Thr Tyr Leu Leu Ser Arg Thr Pro Pro Pro Pro Thr Thr Pro
2495 2500 2505
Gly Thr His Ile Pro Cys Asp Leu Thr Asp Pro His Gln Leu Thr
2510 2515 2520
Gln Ala Leu His His Ile Pro Gln Pro Leu Thr Ala Ile Tyr His
2525 2530 2535
Thr Ala Ala Thr Leu Asn Asp Ala Thr Leu His Asn Leu Thr Pro
2540 2545 2550
His His Leu Thr Thr Thr Leu Thr Thr Lys Ala His Thr Ala Trp
2555 2560 2565
His Leu His Gln Gln Thr Gln His His Pro Leu Thr His Phe Ile
2570 2575 2580
Leu Tyr Ser Ser Ala Ala Ala Thr Leu Gly Ser Pro Gly Gln Ala
2585 2590 2595
Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala Leu Ala Thr His
2600 2605 2610
Arg His Thr Gln Gly Gln Pro Ala Thr Thr Ile Ala Trp Gly Met
2615 2620 2625
Trp Gln Thr Thr Thr Asn Leu Thr Thr Gln Leu Thr His Thr Asp
2630 2635 2640
Arg Gln Arg Val Arg Asp Gly Phe Arg Pro Leu Thr Glu Ala Glu
2645 2650 2655
Gly Arg His Phe Leu Asp Leu Ser Leu Ala Thr Asp Glu Pro Phe
2660 2665 2670
Val Ile Ala Ala Ile Pro Ala Ala Pro Glu Ser Val Ser Val Pro
2675 2680 2685
Glu Ser Glu Pro Ala Arg Arg Arg Val Glu Arg Pro Thr Val Arg
2690 2695 2700
Thr Gly Glu Asp Arg Gly Arg Asp Leu Leu Ala Val Val Cys Ser
2705 2710 2715
Ala Thr Ala Ala Val Leu Gly His Pro Asp Ala Ser Gly Ile Gly
2720 2725 2730
Pro Ala Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Ser Gly
2735 2740 2745
Ile Arg Leu Arg Asn Arg Leu Ala Glu Thr Thr Gly Val Arg Leu
2750 2755 2760
Ser Ala Thr Ala Val Phe Asp His Pro Thr Pro Asp Ala Leu Ala
2765 2770 2775
Thr Gln Leu Ala Ala Ala Leu Arg Ser Ala Gly Ala Pro Pro Gly
2780 2785 2790
Gly Ala Glu Thr Ala Ala Pro Ala Pro Val Pro Pro Lys Ala Val
2795 2800 2805
Ala Gly Asp Glu Pro Leu Ala Ile Val Ala Met Ala Cys Arg Met
2810 2815 2820
Pro Gly Gly Ala Asp Thr Pro Glu Asp Leu Trp Asn Leu Val Glu
2825 2830 2835
Ser Gly Gly Asp Gly Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp
2840 2845 2850
Asp Leu Ala Ala Leu Tyr Asp Pro Asp Pro Asp Ala Ile Gly Lys
2855 2860 2865
Val Ser Val Arg His Gly Gly Phe Leu Ala Gly Ala Ala Asp Phe
2870 2875 2880
Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met
2885 2890 2895
Asp Pro Gln Gln Arg Leu Ile Leu Glu Val Ser Trp Glu Ala Phe
2900 2905 2910
Glu Arg Ala Gly Ile Leu Pro Ala Ser Val Arg Gly Ser Asp Ala
2915 2920 2925
Gly Val Phe Met Gly Ala Phe Gly Gln Gly Tyr Gly Ala Gly Val
2930 2935 2940
Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr Pro Thr Ser Val Leu
2945 2950 2955
Ser Gly Arg Leu Ser Tyr Tyr Phe Gly Phe Glu Gly Pro Ser Val
2960 2965 2970
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
2975 2980 2985
Ala Ala Arg Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val
2990 2995 3000
Gly Gly Val Thr Val Met Ala Thr Thr Thr Gly Phe Val Glu Phe
3005 3010 3015
Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe
3020 3025 3030
Ala Asp Thr Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Val
3035 3040 3045
Leu Ile Val Glu Arg Leu Ser Asp Ala Thr Arg Leu Gly His Pro
3050 3055 3060
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala
3065 3070 3075
Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ala Gln Gln Arg Val
3080 3085 3090
Ile Glu Arg Ala Leu Ala Asp Ala Gly Leu Ala Pro Gly Glu Val
3095 3100 3105
Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro
3110 3115 3120
Ile Glu Ala Gln Ala Leu Glu Ala Ala Tyr Gly Ala Gly Arg Glu
3125 3130 3135
Arg Pro Leu Leu Ile Gly Ser Leu Lys Ser Asn Ile Gly His Thr
3140 3145 3150
Gln Ala Ala Ala Gly Ile Ala Gly Val Ile Lys Met Val Met Ala
3155 3160 3165
Met Arg His Gly Val Leu Pro Arg Thr Leu Tyr Val Asp Glu Pro
3170 3175 3180
Ser Arg His Val Asp Trp Asp Gly Asn Val Arg Leu Leu Arg Arg
3185 3190 3195
Asn Glu Pro Trp Pro Asp Thr Gly Arg Ala Arg Arg Ala Gly Val
3200 3205 3210
Ser Ser Phe Gly Ile Ser Gly Ala Asn Ala His Val Val Leu Glu
3215 3220 3225
Ser Gly Pro Ser Ala Ala Pro Gly Ser Ser Ala Ser Leu Gly Pro
3230 3235 3240
Ser Ala Thr Leu Gly Leu Pro Ala Ala Pro Gly Pro Ser Thr Ala
3245 3250 3255
Pro Val Pro Pro Ala Ala Pro Val Pro Leu Pro Glu Ala Glu Thr
3260 3265 3270
Gln Asp Val Leu Trp Pro Val Ser Ala Arg Thr Ser Asp Gly Val
3275 3280 3285
Arg Asp Val Ala Ala Arg Met Ala Ala Leu Thr Ala Arg Ala Ala
3290 3295 3300
Ala Ile Gly His Ser Leu Ala Thr Thr Arg Thr Ala Met Arg His
3305 3310 3315
Arg Ala Val Val Pro Ala Arg Asp Ala Glu Ala Phe Ala Arg Gly
3320 3325 3330
Glu Glu Val Pro Asp Val Val Arg Gly Thr Ala Asp Ile Thr Asp
3335 3340 3345
Pro Arg Ala Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Ala
3350 3355 3360
Gly Met Gly Ala Glu Leu Leu Ala Ala Glu Pro Val Phe Ala Arg
3365 3370 3375
Arg Leu Gly Glu Cys Ala Ala Ala Leu Ala Pro His Thr Gly Trp
3380 3385 3390
Asp Leu Leu Asp Val Ile Thr Gln Arg Pro Gly Ala Pro Ala Leu
3395 3400 3405
Asp Arg Val Asp Val Val Gln Pro Ala Ser Phe Ala Leu Met Val
3410 3415 3420
Ala Leu Ala Glu Leu Trp Ser Val His Gly Val Ala Pro Ala Ala
3425 3430 3435
Val Val Gly His Ser Gln Gly Glu Val Ala Ala Ala Cys Val Ala
3440 3445 3450
Gly Ala Leu Thr Leu Asp Asp Ala Ala Lys Val Val Ala Leu Arg
3455 3460 3465
Ser Arg Leu Val Ala Ala Glu Leu Ala Gly Arg Gly Gly Met Val
3470 3475 3480
Ala Val Ala Pro Ala Asp Phe Asp Ala Ala Ala Trp Thr Gly Arg
3485 3490 3495
Leu Glu Val Ala Ala Val Asn Gly Pro Ala Ser Ile Val Val Ala
3500 3505 3510
Gly Ala Ala Asp Ala Val Glu Glu Phe Leu Ala Ala Ala Pro Arg
3515 3520 3525
Ala Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Ala His Val
3530 3535 3540
Glu Thr Val Arg Gln Ala Leu Leu Asp Ala Leu Ala Asp Leu Thr
3545 3550 3555
Pro Arg Ala Pro Glu Ile Pro Phe Phe Ser Thr Val Asp Gly Glu
3560 3565 3570
Trp Leu Asp Arg Pro Ala Asp Ala Ala Tyr Trp Tyr Asp Asn Val
3575 3580 3585
Arg Arg Pro Val Arg Phe Gly Val Ala Thr Ser Arg Leu Asp Glu
3590 3595 3600
Leu Gly Tyr Arg Val Phe Val Glu Thr Ser Pro His Pro Val Leu
3605 3610 3615
Thr Pro Ala Leu Glu Asp Thr Leu Ala Gly Gln Pro Asn Thr Val
3620 3625 3630
Val Val Gly Thr Leu Arg Arg Gly Glu Gly Gly Pro Arg Arg Phe
3635 3640 3645
Gly Lys Ser Leu Ala Ala Leu Trp Val Arg Gly Val Pro Val Thr
3650 3655 3660
Trp Ser Phe Gly Val Ser Arg Ser Val Pro Leu Pro Thr Tyr Pro
3665 3670 3675
Phe Arg Arg Asp Arg Tyr Trp Ile Asp Ala Glu Pro Ala Gly Gly
3680 3685 3690
Ser Gly His Pro Leu Leu Ala Ser Leu Val Asp Arg Ala Asp Gly
3695 3700 3705
Glu Gly Ala Leu Ala Thr Ala Leu Phe Ser Val Arg Arg Gln Pro
3710 3715 3720
Trp Leu Thr Asp His Glu Val Asp Gly Arg Ile Ile Val Pro Gly
3725 3730 3735
Ser Ala Leu Val Glu Leu Leu Ala Glu Ala Gly Thr Arg Leu Gly
3740 3745 3750
Thr Pro Ala Ile Ala Glu Leu Thr Ile Val Val Pro Leu Val Val
3755 3760 3765
Asp Ala Asp Ala Ala Thr Glu Val Gln Phe Thr Val Gly Ser Glu
3770 3775 3780
Val Ser Gly Gln Arg Pro Val Arg Leu His Ser Arg Thr Gly Thr
3785 3790 3795
Gly Pro Trp Thr Leu Val Ala Thr Gly Ala Leu Ser Ala Glu Thr
3800 3805 3810
Arg Glu Pro Ala Thr Pro Glu Trp Pro Pro Pro Asp Ala Asp Pro
3815 3820 3825
Val Asp Pro Ala Gly Phe Tyr Asp Thr Leu Pro Leu Ser Tyr Gly
3830 3835 3840
Pro Ala Phe Arg Ala Val Thr Ala Leu Trp Ala Gly Arg Gly Arg
3845 3850 3855
Ala Tyr Ala Ser Val Arg Leu Gly Glu Gln Leu Thr Asp Ala Arg
3860 3865 3870
Tyr Gly Leu His Pro Val Leu Leu Asp Ala Ala Leu His Ala Leu
3875 3880 3885
Gly Met Leu Phe Asp Asp Pro Glu Arg Arg Arg Leu Ala Phe Ser
3890 3895 3900
Trp Thr Gly Val Arg Met Tyr Thr Arg Ala Ala Thr Ala Leu Arg
3905 3910 3915
Val Leu Leu Glu Arg Val Gly Ala Asp Thr Ile Arg Val Leu Ala
3920 3925 3930
Met Asp Glu His Gly Ala Pro Val Leu Glu Ala Asp Gly Leu Thr
3935 3940 3945
Val Arg Gly Ala Glu Pro Gly Asn Asp Ala Leu Phe Glu Val Val
3950 3955 3960
Trp Val Pro Val Pro Ala Ala Pro Val Pro Gly Trp Thr Tyr His
3965 3970 3975
Ala Asp Val Pro Glu Gly Asp Thr Pro Pro Val Val Val Leu Pro
3980 3985 3990
Leu Glu Pro Gly Asp Pro Gly Asp Pro Gly Asp Pro Gly Asp Pro
3995 4000 4005
Gly Asp Pro Gly Asp Arg Gly Gly Ser Pro Gly Val Arg Ala Arg
4010 4015 4020
Glu Leu Gly Arg Asp Leu Leu Ala Thr Val Gln Thr Trp Leu Ala
4025 4030 4035
Asp Pro Arg Arg Ala Gly Ser Arg Leu Val Val Val Thr Arg Thr
4040 4045 4050
Gly Asp Pro Ala Gln Glu Ala Leu Gly Gly Leu Val Arg Thr Ala
4055 4060 4065
Gly Thr Glu Asn Pro Gly Arg Val Gly Leu Ile Glu Ala Asp Glu
4070 4075 4080
Ile Thr Pro Ala Thr Val Ala Ala Gly Leu Ala Ala Gly Asp Glu
4085 4090 4095
Pro Arg Val Arg Val Ala Gly Gly Thr Val Arg Ala Ala Arg Leu
4100 4105 4110
Arg Arg Val Ala Ala Ala Ala Gly Ala Ser Ala Leu Thr Gly Gly
4115 4120 4125
Thr Val Leu Val Thr Gly Gly Thr Gly Gly Leu Gly Arg Leu Leu
4130 4135 4140
Val Asp His Leu Leu Thr Val His Glu Ala Ala Glu Ile Val Val
4145 4150 4155
Ala Ser Arg Gly Gly Arg Pro Gly Gly Ala Pro Glu Asp Asp Arg
4160 4165 4170
Val Arg Tyr Ala Ala Val Asp Val Thr Asp Arg Asp Ala Leu Ala
4175 4180 4185
Ala Leu Val Asp Gly Ile Ser Gly Arg Leu Arg Ala Val Val His
4190 4195 4200
Met Ala Gly Ile Val Asp Asp Ala Val Val Ala Thr Met Arg Pro
4205 4210 4215
Gln Gln Trp Asp Asp Val Leu Arg Val Lys Ala Asp Val Ala Trp
4220 4225 4230
His Leu His Glu Leu Thr Arg Asp Thr Glu Leu Ala Ala Phe Val
4235 4240 4245
Leu Tyr Ser Ser Ile Ser Ala Thr Phe Gly Gly Ala Gly Gln Ala
4250 4255 4260
Asn Tyr Ala Thr Gly Asn Ala Phe Leu Asp Ala Leu Ala Arg His
4265 4270 4275
Arg Arg Asp Arg Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu
4280 4285 4290
Trp Asp Glu Ala Asp Gly Met Gly Gly Arg Leu Thr Ser Thr Asp
4295 4300 4305
Leu Gly Arg Ile Ala Arg Gly Gly Met Ile Pro Met Thr Ala Ala
4310 4315 4320
Gln Gly Leu Ala Leu Phe Asp Ala Ala Leu His Ser Asp Arg Ala
4325 4330 4335
Ala Leu Val Pro Val Arg Leu Asp Leu Ala Ala Val Ala Ala Ala
4340 4345 4350
Asp His Val Pro Pro Ile Leu Arg Asp Leu Val Pro Ala Ala Arg
4355 4360 4365
Arg Thr Pro Ala Pro Ala Gly Ser Arg Asp Met Leu Glu Leu Val
4370 4375 4380
Arg Thr Ser Ala Ala Ala Val Leu Gly His Arg Asp Val His Ala
4385 4390 4395
Val Glu Pro Leu Arg Ala Phe Lys Asp Val Gly Phe Asp Ser Leu
4400 4405 4410
Thr Gly Val Glu Leu Arg Asn Arg Leu Thr Asp Ala Thr Gly Leu
4415 4420 4425
Thr Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Pro Gln Ala
4430 4435 4440
Leu Ala Ala His Leu Asp Glu Leu Ala Gly Thr Arg Ala Ala Thr
4445 4450 4455
Arg Arg Arg Thr Pro Thr Pro Ala Arg Arg His Asp Glu Pro Leu
4460 4465 4470
Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Met Ser
4475 4480 4485
Pro Asp Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly Ile
4490 4495 4500
Thr Ala Phe Pro Ala Asp Arg Gly Trp Asp Leu Glu Ala Leu Tyr
4505 4510 4515
Asp Pro Asp Pro Asp Arg Pro Gly Thr Ser Thr Val Arg His Gly
4520 4525 4530
Gly Phe Leu Pro Gly Ala Ala His Phe Asp Ala Ala Phe Phe Gly
4535 4540 4545
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Ile
4550 4555 4560
Val Leu Glu Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp
4565 4570 4575
Ala His Thr Leu Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Gly
4580 4585 4590
Tyr Phe Tyr Gly Tyr Gly Ser Gly Ser Asp Arg Gly Gly Phe Gly
4595 4600 4605
Ala Thr Ser Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr
4610 4615 4620
Phe Tyr Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys
4625 4630 4635
Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ser Leu Arg
4640 4645 4650
Thr Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met
4655 4660 4665
Ala Ser Pro Ser Gly Phe Val Asp Phe Ser Gln Gln Arg Gly Leu
4670 4675 4680
Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly
4685 4690 4695
Thr Ala Phe Ala Glu Gly Ser Gly Val Leu Val Val Glu Arg Leu
4700 4705 4710
Ser Asp Ala Glu Arg Leu Gly His Arg Val Leu Ala Val Val Arg
4715 4720 4725
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
4730 4735 4740
Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
4745 4750 4755
Asn Ala Arg Leu Glu Pro Ser Asp Val Asp Ala Val Glu Ala His
4760 4765 4770
Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Arg Ala Leu
4775 4780 4785
Leu Glu Thr Tyr Gly Gln Asp Arg Thr Ala Pro Leu Leu Leu Gly
4790 4795 4800
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val
4805 4810 4815
Ala Gly Ile Ile Lys Met Val Leu Ala Met Arg His Gly Thr Leu
4820 4825 4830
Pro Pro Thr Leu His Val Asp Arg Pro Thr Thr His Val Asp Trp
4835 4840 4845
Ser Ala Gly Ser Ile Glu Leu Leu Thr Glu Pro Arg Pro Trp Pro
4850 4855 4860
Asp Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val
4865 4870 4875
Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Arg Pro Gln Pro
4880 4885 4890
Glu Ala Glu Thr Pro Pro Gly Ala His Pro Ala Pro Leu Leu Ile
4895 4900 4905
Ser Ala Arg Thr Pro Arg Ala Leu His Glu His Thr Thr Arg Ile
4910 4915 4920
Arg Ala Phe Arg Asp Ser Gly Ser Cys Asp Glu His Ala Val Ala
4925 4930 4935
Ser Ala Leu Leu Ala Arg Thr Ala Phe Arg His Arg Ala Ala Leu
4940 4945 4950
Ile Gly Thr Asp Leu Ile Thr Gly Thr Ala Glu Pro Asp Arg Arg
4955 4960 4965
Leu Val Trp Leu Tyr Ser Gly Gln Gly Ser Gln Arg Pro Gly Met
4970 4975 4980
Gly Asp Glu Leu Ala Ala Ala Tyr Asp Val Phe Ala Arg Thr Arg
4985 4990 4995
Arg Asp Val Leu Asp Ala Leu Arg Val Pro Thr Gly Leu Asp Leu
5000 5005 5010
His Asp Thr Gly Tyr Ala Gln Pro Ser Val Phe Ala Leu Gln Val
5015 5020 5025
Ala Leu Ser Ala Gln Leu Asp Thr Trp Gly Val Arg Pro Asp Val
5030 5035 5040
Leu Val Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala
5045 5050 5055
Gly Val Trp Ser Leu Asp Asp Ala Cys Thr Leu Val Ala Ala Arg
5060 5065 5070
Ala Arg Leu Met Gln Ala Leu Pro His Gly Gly Ala Met Ala Ala
5075 5080 5085
Val Val Ala Ser Glu Gln Glu Ala Gln Pro Leu Leu Arg Asp Gly
5090 5095 5100
Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Ile Val Leu Ser
5105 5110 5115
Gly Asp Glu Ala Thr Val Leu Asp Thr Ala Ala Arg Leu Gly Arg
5120 5125 5130
Phe Thr Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met
5135 5140 5145
Glu Pro Met Leu Asp Ala Phe Arg Glu Val Ala Glu Gly Leu Thr
5150 5155 5160
Tyr His Glu Pro Lys Ile Pro Met Ala Ala Gly Ala Glu Cys Ala
5165 5170 5175
Thr Pro Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe
5180 5185 5190
Gly Glu Gln Ile Ala Ala Tyr Asp Gly Ala Leu Leu Leu Glu Val
5195 5200 5205
Gly Pro Asp Arg Asn Leu Ser Arg Leu Val Asp Gly Ile Pro Met
5210 5215 5220
Leu His Gly Asp Asp Glu Pro Arg Ser Ala Met Thr Ala Leu Ala
5225 5230 5235
Arg Leu His Thr Ser Gly Ala Thr Val Asp Trp Pro Lys Val Ile
5240 5245 5250
Gly Pro Ala Pro Ala Ser Pro Pro Asp Leu Pro Thr Tyr Pro Phe
5255 5260 5265
Ala Arg Asp Arg Tyr Trp Ser Ala Ser Arg Gly Ser Gly Asp Thr
5270 5275 5280
Ala Pro Ala Gly Gln Leu Pro Val Asp His Pro Val Leu Thr Ala
5285 5290 5295
Ala Val Ser Ile Pro Gly Ser Gly Glu Leu Val Leu Thr Gly Arg
5300 5305 5310
Val Asp Ala Ala Asp Pro Leu Ala His Ser Val His Gly Ile Ala
5315 5320 5325
Val Leu Pro Ala Ala Val Leu Val Asp Leu Ala Val Thr Ala Gly
5330 5335 5340
Asp Glu Ala Gly Cys Gly Val Leu Glu Thr Phe Ala Val Asp Thr
5345 5350 5355
Pro Leu Val Leu Pro Gln Ser Gly Gly Ala Ala Leu Ser Val Thr
5360 5365 5370
Val Ala Ala Pro Arg Glu Asp Gly Arg Arg Thr Val Thr Val His
5375 5380 5385
Ala Arg His Gly Asn Gly Glu Trp Thr Gly His Ala Thr Gly Ile
5390 5395 5400
Leu Ala Ala Glu Ala Pro Ala Pro Ala Pro Ala Leu Ala Ala Pro
5405 5410 5415
Ser Val Trp Pro Pro Ala Thr Ala Arg Pro Leu Asp Val Gly Glu
5420 5425 5430
Gln Ala Asp Ala Leu Ala Arg Ala Gly His Thr Gly Gly Pro Ala
5435 5440 5445
Gln Pro Arg Pro His Ala Ala Trp Thr Asp Glu Gly Ala Val Tyr
5450 5455 5460
Ala Glu Val Ser Leu Ala Glu Asp Arg Leu Ser Glu Ala Gly Arg
5465 5470 5475
Tyr Gly Leu His Pro Ala Leu Leu Gly Ala Ala Leu Thr Leu Ala
5480 5485 5490
Ala Ala Gly Thr Asp Leu Pro Tyr Ala Phe Asp Asp Val Arg Val
5495 5500 5505
His Thr Gly Gly Ala Thr Ala Val Arg Val Ala Val Thr Ala His
5510 5515 5520
Gly Val His Ile Thr Asp Gly Thr Gly Arg Pro Val Ala Thr Val
5525 5530 5535
Gly Ala Val Arg Ser Arg Pro Leu Thr Val Glu Gly Ala Val Pro
5540 5545 5550
Gly Leu Leu Arg Pro Val Leu Ala Glu Pro Ala Glu Ile Gln Glu
5555 5560 5565
Pro Pro Pro Thr Thr Ala Thr Thr Gly Gly Leu Asp Asp Pro Thr
5570 5575 5580
Val Pro Asp Val Val Ile Leu Pro Ala Tyr Gly Thr Gly Gly Ala
5585 5590 5595
Pro Leu Asp Glu Val Arg Arg Leu Gly Ala Glu Val Leu Ala Ala
5600 5605 5610
Leu Gln Arg Phe Leu Thr Asp Asp Arg Tyr Ala Glu Ala Val Leu
5615 5620 5625
Ala Val His Thr Gly Pro Gly Leu Ala Ala Ala Ala Val Ala Gly
5630 5635 5640
Leu Val Arg Thr Ala Gln Ala Glu His Pro Gly Arg Ile Ala Leu
5645 5650 5655
Val Asp Ala Ala Pro Asp Thr Ala Ala Pro Leu Leu Ala Ala Ala
5660 5665 5670
Ala Val Leu Gly Glu Pro Gln Thr Val Leu Arg Asp Gly Arg Thr
5675 5680 5685
Tyr Pro Arg Arg Leu Thr Pro Ala Ala Pro Ala Gly Asp Ala Pro
5690 5695 5700
Ala Leu Asp Pro Asp Gly Thr Val Leu Ile Thr Gly Gly Ser Gly
5705 5710 5715
Thr Leu Ala Gly Ile Ile Ala Arg His Leu Val Asp His Tyr Gly
5720 5725 5730
Val Arg Arg Leu Leu Met Leu Ser Arg Gly Gly Thr Ala Asn Asp
5735 5740 5745
Val Pro Gly Ala His Val Thr Ala Val Ala Cys Asp Ile Ala Asn
5750 5755 5760
Arg Asp Glu Leu Val Ser Ala Leu Ala Gly Ile Asp Pro Ala His
5765 5770 5775
Pro Leu Thr Ala Val Val His Thr Ala Ala Val Ile Asp Asp Gly
5780 5785 5790
Val Leu Thr Gly Leu Thr Pro Glu Arg Leu Asp Thr Val Leu Arg
5795 5800 5805
Pro Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Lys Asp
5810 5815 5820
Gln Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser Ala Ala Gly Val
5825 5830 5835
Leu Gly Ser Pro Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala Phe
5840 5845 5850
Leu Asp Glu Leu Ala Val Gln Arg Arg Ala Thr Gly Leu Pro Ala
5855 5860 5865
Leu Ser Leu Ala Trp Gly Leu Trp Glu Pro Glu Ser Gly Leu Thr
5870 5875 5880
Ala Gly Ala Gly Asp Arg Leu Arg Arg Ser Gly Val Thr Ala Leu
5885 5890 5895
Ser Thr Glu Arg Gly Leu Ala Leu Phe Asp Ala Ala Leu Arg Ser
5900 5905 5910
Pro Asp Ala Ala Leu Val Ala Ala Asp Pro Ala Gly Leu Gly Asp
5915 5920 5925
Thr Pro Leu Leu Arg Ala Ala Gly Arg Val Pro Arg Arg Arg Thr
5930 5935 5940
Ala Gly Ala Gly Ala Leu Ala Asp Arg Ile Ala Gly Leu Ser Ala
5945 5950 5955
Ala Glu Ala Glu Lys Val Ala Leu Ala Val Val Arg Glu Cys Ala
5960 5965 5970
Ala Ala Val Leu Gly His Asp Gly Ala Asp Arg Ile Glu Pro Thr
5975 5980 5985
Ala Thr Phe Lys Glu Leu Gly Ala Asp Ser Leu Thr Ala Val Arg
5990 5995 6000
Leu Arg Asn Ala Leu Thr Glu Ala Thr Gly Val Arg Leu Pro Ala
6005 6010 6015
Thr Ala Val Phe Asp Phe Pro Thr Pro Gln Ala Val Ala Ala Lys
6020 6025 6030
Leu Thr Thr Ala Leu Ser Gly Arg Pro Ala Glu Pro Thr Arg Ala
6035 6040 6045
Pro Thr Pro Ala Met Ala Val Asp Glu Pro Leu Ala Ile Val Gly
6050 6055 6060
Met Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro Asp Gly Leu
6065 6070 6075
Trp Arg Leu Leu Glu Ser Gly Gly Glu Gly Ile Thr Ala Phe Pro
6080 6085 6090
Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Tyr Asp Pro Asp Pro
6095 6100 6105
Gly His Pro Gly Thr Ser Thr Val Arg His Gly Gly Phe Leu Pro
6110 6115 6120
Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg
6125 6130 6135
Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Ile Val Leu Glu Thr
6140 6145 6150
Ser Trp Glu Ala Leu Glu Gln Ala Gly Ile Val Pro Gly Thr Leu
6155 6160 6165
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Ser Asp Gly
6170 6175 6180
Tyr Gly Leu Gly Thr Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr
6185 6190 6195
Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu
6200 6205 6210
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
6215 6220 6225
Val Ala Leu His Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys
6230 6235 6240
Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Ser
6245 6250 6255
Gly Phe Val Glu Phe Ser Gln Gln Arg Gly Leu Ala Ser Asp Gly
6260 6265 6270
Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr Ala Phe Ala
6275 6280 6285
Glu Gly Ser Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Glu
6290 6295 6300
Arg Leu Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val
6305 6310 6315
Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro
6320 6325 6330
Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu
6335 6340 6345
Glu Pro Ser Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr
6350 6355 6360
Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala Thr Tyr
6365 6370 6375
Gly Gln Ser Arg Thr Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser
6380 6385 6390
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile
6395 6400 6405
Lys Met Val Leu Ala Met His His Gly Thr Leu Pro Arg Thr Leu
6410 6415 6420
His Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Ala Gly Gly
6425 6430 6435
Val Glu Leu Leu Thr Glu Ala Arg Pro Trp Pro Gly Thr Ser Arg
6440 6445 6450
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn
6455 6460 6465
Ala His Val Ile Leu Glu Ala Pro Ala Ala Pro Asp Ser Pro Ser
6470 6475 6480
Ala Ala Ser Pro Ser Val Ala Pro Arg Glu Pro Leu Phe Leu Thr
6485 6490 6495
Glu Arg Thr Pro Leu Pro Val Ser Ala Arg Thr Pro Glu Ala Val
6500 6505 6510
Glu Gly Gln Ile Gln Arg Leu Arg Ala His Leu Ala Glu His Pro
6515 6520 6525
Gly Asp Asp Pro Arg Thr Val Ala Ala Ala Leu Phe Ser Thr Arg
6530 6535 6540
Thr Glu Phe Pro His Arg Ala Val Leu Leu Gly Glu Gly Ala Val
6545 6550 6555
Thr Gly Thr Ala Leu Thr Arg Pro Arg Thr Val Phe Val Phe Pro
6560 6565 6570
Gly Gln Gly Ser Gln Trp Leu Gly Met Gly Leu Lys Leu Met Ala
6575 6580 6585
Glu Ser Pro Val Phe Ala Ala Arg Met Arg Glu Cys Ala Asp Ala
6590 6595 6600
Leu Ala Glu His Thr Gly Arg Asp Leu Ile Ala Met Leu Glu Asp
6605 6610 6615
Pro Ala Val Lys Ser Arg Val Asp Val Val His Pro Val Cys Trp
6620 6625 6630
Ala Val Met Met Ser Leu Ala Ala Val Trp Glu Ala Ala Gly Val
6635 6640 6645
Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala
6650 6655 6660
Ala Cys Val Ala Gly Ala Ile Thr Leu Glu Asp Gly Ala Arg Leu
6665 6670 6675
Val Ala Leu Arg Ser Ala Leu Leu Gln Arg Glu Leu Ala Gly His
6680 6685 6690
Gly Ala Met Gly Ser Ile Ala Phe Pro Ala Ala Asp Val Glu Ala
6695 6700 6705
Ala Ala Ala Gln Val Asp Asn Val Trp Val Ala Gly Arg Asn Gly
6710 6715 6720
Thr Gly Thr Thr Ile Val Ser Gly Arg Pro Asp Ala Val Glu Thr
6725 6730 6735
Leu Ile Ala Arg Tyr Glu Ala Arg Gly Val Trp Val Thr Arg Leu
6740 6745 6750
Val Val Asp Cys Pro Thr His Thr Pro Phe Val Asp Pro Leu Tyr
6755 6760 6765
Asp Glu Phe Gln Arg Ile Ala Ala Ala Thr Thr Ser Arg Thr Pro
6770 6775 6780
Arg Ile Pro Trp Phe Ser Thr Ala Asp Glu Arg Trp Ile Asp Ser
6785 6790 6795
Pro Leu Asp Asp Glu Tyr Trp Phe Arg Asn Leu Arg Asn Pro Val
6800 6805 6810
Gly Phe Ala Ala Ala Val Ala Ala Ala Arg Glu Pro Gly Asp Thr
6815 6820 6825
Val Phe Val Glu Val Ser Ala His Pro Val Leu Leu Pro Ala Ile
6830 6835 6840
Asn Gly Thr Thr Val Gly Thr Leu Arg Arg Gly Gly Gly Ala Asp
6845 6850 6855
Gln Val Val Asp Ser Leu Ala Lys Ala Tyr Thr Ala Gly Val Ala
6860 6865 6870
Val Asp Trp Pro Thr Val Val Ala Ala Pro Gly Thr Ala His Asp
6875 6880 6885
Thr Thr Arg Thr Ala Ser Gly Pro Val Pro Gly Pro Ala His Asp
6890 6895 6900
Leu Pro Thr Tyr Ala Phe His His Glu Arg Tyr Trp Ile Glu Pro
6905 6910 6915
Ser Ser Gly Thr Asp Ala Thr Gly Leu Gly Leu Asp Ala Val Asp
6920 6925 6930
His Pro Leu Leu Ala Ala Ser Val Ala Leu Pro Asp Thr Asp Glu
6935 6940 6945
Thr Leu Leu Thr Gly Arg Phe Ser Leu Ala Thr His Pro Trp Leu
6950 6955 6960
Ala Gly His Ser Val Ala Gly Glu Val Leu Leu Pro Gly Pro Val
6965 6970 6975
Phe Val Glu Leu Ala Gly Arg Ala Ala Asp Glu Thr Gly Cys Asp
6980 6985 6990
Leu Leu Asp Glu Leu Val Ile Glu Thr Pro Leu Ala Leu Pro Ala
6995 7000 7005
Thr Gly Ala Val Gln Val Arg Val Thr Val Ala Ala Ala Asp Asp
7010 7015 7020
Gly Gly Arg Arg Ala Val Arg Ile His Ala Arg Lys Asp Gly Asp
7025 7030 7035
Gly Thr Trp Thr Arg His Ala Ser Gly Arg Ala Gly Ile Ala Thr
7040 7045 7050
Ala Glu Pro Ala Thr Thr Asp Gly Pro Trp Pro Pro Ala His Ala
7055 7060 7065
Glu Gln Leu Asp Thr Ala Glu Phe Tyr Arg Arg Leu Asp Asp Glu
7070 7075 7080
Gly Tyr Gly Phe Gly Pro Gly Phe Arg Gly Leu Ser Ala Ala Trp
7085 7090 7095
Arg His Gly Asp Thr Val Phe Ala Glu Val Ala Val Asp Gly Ala
7100 7105 7110
Leu Ala Arg Asp Ala Ser Arg Tyr Thr Leu His Pro Ala Leu Leu
7115 7120 7125
Val Thr Ala Leu Gln Ala Gly Ser Leu Ser Ala Gly Ser Glu Asp
7130 7135 7140
Ala Gly Val Arg Val Pro Phe Ala Phe Ser Gly Val Arg Val His
7145 7150 7155
Ser Ser Gly Ala Thr Lys Ala Arg Val Thr Phe Thr Ala Ala Asp
7160 7165 7170
Gly Gly Ala Arg Val His Leu Ala Asp Glu Thr Gly Arg Pro Val
7175 7180 7185
Ala Glu Ile Gly Ser Leu Val Thr Arg Pro Pro Ala Thr Pro Asp
7190 7195 7200
Pro Gly Gly Asp Val Arg Leu Tyr Arg Arg Thr Trp Thr Gly Val
7205 7210 7215
Arg Ala Pro Ala Ala Pro Gly Thr Thr Ala Val Arg Tyr Pro Asp
7220 7225 7230
Pro Gly Asp Gly Thr Ala Pro Gly Gly Asp Pro Phe Asp Thr Thr
7235 7240 7245
Arg Pro Asp Val Leu Val Val Arg Ala Ser Asp Pro Ala Asp Val
7250 7255 7260
Arg Thr Ala Leu Asp Asp Pro Arg Thr Ala Gly Ala Thr Leu Val
7265 7270 7275
Val Ser Ala Ala Ala Gly Thr Thr Ala Gly Ala Val Ala Ala Leu
7280 7285 7290
Val Asp Thr Ser Pro Pro Gly Arg Ile Val Leu Val Gln Thr Ala
7295 7300 7305
Asp Thr Ile Thr Pro Arg Arg Ala Ala Ala Phe Ala Arg Leu Asp
7310 7315 7320
Glu Pro His Leu Arg Leu Thr Gly Gly Arg Leu Glu Ala Pro Arg
7325 7330 7335
Leu Val Pro Ala Pro Pro Arg Thr Asp Pro Pro Pro Tyr Gly Gly
7340 7345 7350
Val Val Leu Leu Ala Gly Gly Ser Asp Asp Leu Ala Arg Gln Leu
7355 7360 7365
Thr Gly Gln Gly Ala Glu Val Ile Arg His Glu Pro Gly Arg Leu
7370 7375 7380
Pro Gly Ser Pro Val Thr Ala Val Val His Ala Ala Gly Thr Ala
7385 7390 7395
Glu Ser Ala Trp Glu Leu His Arg Leu Thr Arg Glu Leu Pro Leu
7400 7405 7410
Asp Ala Phe Val Leu Leu Val Pro Pro Gly Glu Ala Ala Gly Pro
7415 7420 7425
Trp Glu Ala Leu Ala Glu Leu Arg Arg Ala Glu Gly Leu Pro Ala
7430 7435 7440
Met Ala Phe Thr Ala Ala Glu Asp Arg Gln Thr Glu Leu Leu Asp
7445 7450 7455
Ala Ala Arg Ala Thr Gly Glu Ala Val Val Val Ala Thr Ala Pro
7460 7465 7470
Pro Pro Pro Gly Asp Pro Ser Pro Leu Trp Arg Pro Val Arg Arg
7475 7480 7485
Pro Thr Arg Arg Ala Ala Ala Ser Gly Gly Thr Leu Pro Glu Arg
7490 7495 7500
Leu Pro Asp Leu Ser Pro Glu Glu Gln Glu Gln Ala Val Leu Gly
7505 7510 7515
Leu Val Arg Asp Thr Ala Ala Ala Leu Leu Gly His Ala Asp Ala
7520 7525 7530
Arg Ala Val Thr Ala Thr Ala Ala Phe Lys Asp Leu Gly Val Asp
7535 7540 7545
Ser Leu Thr Ala Leu Gly Leu Arg Asp Arg Leu Ala Glu Ala Leu
7550 7555 7560
Ala Thr Pro Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Ala Ala
7565 7570 7575
Gly Thr Leu Thr Arg His Leu Leu Thr Leu Leu Asn Pro Asp Gly
7580 7585 7590
Ser Ala Thr Gln Asp Gly Gly Glu Pro Pro Val Ala Arg Thr Pro
7595 7600 7605
Glu Asn Pro Gln Ala Ala Glu Pro Asp Asn Lys Ser Ile Asp Asp
7610 7615 7620
Glu Leu Leu Asp Glu Glu Leu Ile Asp Asp Met Asp Ala Asp Ala
7625 7630 7635
Leu Ile Ala His Val Arg Lys Gly
7640 7645
<210> 35
<211> 22941
<212> DNA
<213> Streptomyces sp. GT1005
<400> 35
gtgcacgaat tgctgcgcgt gaacgccgaa cggcagggtg accggatcgc ctacgtggat 60
tcccgacgcg ccgtgacgta cgcgcagctc cggctcagga ccggccggat cgccggtcac 120
ctcgccgcgg caggggtggg ccgtggcgac cgtatcgcgc tgctgctcgg aaaccgggtc 180
gagaccatcg agacctatat cgccgccgcg cgtgccgccg ccgtcgccgt gccgctcaac 240
ccggacgccg gcgatgcgga gatcgcccac ttcctcaccg actcgggcgc gaccgtcctg 300
gtcaccgacg acctccacct cgaccaggtg cgccgggtcg gcaccgatgc cacggtcgta 360
ctcgcgggac ggcgggatcc gggctgcacc gcgtacgagg acctcgccgg aaccgaaccg 420
gcgtacccgc cccgcgacga cctcgccctg gacgaacccg cctggatgct ctacacgtcc 480
ggaacgaccg gacgcccgaa gggagtcgtc tccgcccagc gaagcggcct gtggtccgcg 540
ctgtactgcg acgtaccgtc ctgggaactc accgagaccg acgaactgct ctggcccgca 600
ccgctcttcc acagcctcgg ccaccatctc tgcctgctcg cggtcctcac cgtcggcgcg 660
tccgcccgga tcctcggcgg cttcgtcgcg cgcgacgtcc tcgacgccct ggccgaacac 720
ccgagcaccg tgctcgtcgg cgtaccgacg atgtaccgct accttctcgg cgccgtgtcc 780
ggcgaaccgg aggcaggcgc gctgcgcgcc gcgctggtcg cgggatccac cgcacccgcc 840
tcgctcacgg cggacttcga agcggccttc ggcgtaccgc tgctcgatac ctacggctgc 900
accgagacga ccggctcact cacggccaac accctgaccg gcccgagggt tcccggctcg 960
tgcggactgc ccgtccccgg cctgtcgctg cggttcgtcg acccggtgtc cggcgccgac 1020
gtgccgcgcg gcgacgaggg cgagctgtgg gcgagcggac cgagcctcat gctcggctac 1080
cacgagcagc ccgaggcgac cgccgaggtg ctcgtggacg gttggtaccg caccggagac 1140
ctggcacgcc aggcggagac cggacatgtg acgatcaccg ggcgggtcaa ggaactcgtc 1200
atccggggcg gggagaacat ccacccgggg gagatcgaat cagtcgccca ggcagtgccg 1260
ggcgtccggg acgccgcggc ggcgggccgc ccccaccccg tcctcggtga gatacccgtg 1320
ctctacgtcg tcccggaggg acccaccgtc cccaccgacg cgatcctcgc ggagtgccgc 1380
cgccagctcg cctacttcaa ggtgcccgac gagatcctgc agaccacgga gatcccgcgc 1440
accgcatcgg ggaaggtacg ccggggagag ctggccggtc gtacgacacg cctcgtcgcc 1500
accggaagcg gcgagaccgc cctgtgcgaa ctggtgtggg aacggcgcga gctgcccacc 1560
accgtcacgc cggtgccgac cgtcatcacc cgccgtgccg tgggcatcga cccggccgaa 1620
gtgccggacg cggaccaggc cgcgctctgg gacgaggcgc tcaaggacca ggctgccgac 1680
cccggatcgt tcgtgctggt cgatacggac ggcgagccaa cgggcggaga gacaacaggc 1740
cgagagacaa cgggcggaag gacaacgggc ggagagacga cgggcggcga gacgacggac 1800
ggcgagacga cggacggaga agcagccgac gccggtgccg ccggggccgg aagcattgcc 1860
gccgcggcct ctctcggcga gcccctggtc gccctgcgga acggcacggc ctatgtaccc 1920
cggctggtcc acgcggtcac cacccccctg ccgccgggcc cgtgggcact gcgaccgccc 1980
gcctccggaa ccctccgcga cctcgcagtc gccccgtccg acgccccgcc gcaccccctg 2040
gccacgggtg aggtccgtat cgaggtccgc gccgcggggc tgaacttccg cgatgtgctg 2100
atcgcactcg gcacctaccc gggcgacggc gagatgggcg gggaagccgc cggaatcgtg 2160
accgaggtcg ggcccggggt cgacgacctg acgcccgggg accgggtgtt cggcctggtg 2220
caggacgcgt tccggcgcag tgtcgtcgcc gaccggaggc tgatcgcacc ggttccgcag 2280
ggatggtcgt tcccggtcgc cgcttccgtg cccgtcgtgt tcgcgaccgc ctggtacgga 2340
ctcgtcgacg cgggtggcct gcggcccggc cgcaaggtac tgatccacgc cgcgacgggc 2400
ggcgtcggca tggccgccac ccggatcgcc cgccacctcg gcgccgaggt ctacgccacc 2460
gcgagcccgg ccaagcagca cctgctgtac gccgacggct tcgacgccga ccatgtggcg 2520
gactcccgta ccaccgcctt cgcggacgcc ttccccccga tggacgtcgt gctgaactcc 2580
ctcaccggcg aactcctcga cgcctcggtc gcgttgctcg caccggacgg ccggttcatc 2640
gagatgggca agaccgacat ccggcacgac gcacaggagc ccttcgacct gtccgacatc 2700
gcccccgcac ggctgcgcga gatcctggaa ctgctcctgg aactgttcga ccgcggcgag 2760
ctgtccccac tgccgctccg cgcgtgggac atccgccgtg cgcgggatgc gttcacctgg 2820
atgagccggg cccggcacac cggcaagatg gttctcaccg tcccgcagcc gctcgggccg 2880
gacacgccgg tcctggtcac cggggaaggc gccgacgccg tcgccggtct gctgcgccgc 2940
gaagtggact cgggtcccgt gttcaccggc gacgcggatg ccctggcgac ggcggatgcc 3000
gtggacacga gtgcgctcgt gcatatcgtg ctcggcgatc cggccggcgc cgacgcgtac 3060
gcccggtcgc gagcctcgga agggctcccg gccgtcacgc tccacggtct gccgggaatc 3120
gaagaggcag cactcacggc ggagctgatc gaaagggccg tcgcgggcgg cggctcgtac 3180
gtcgtcaccc gcgtcggttc cgccggtgcg cgggccgagg cgatggcagg cgcgacgcca 3240
ccgattctca gcaggctcgc gggacgggcc ggcccggcgg acccggatgg gcccggagcc 3300
gtggacccgg catgggcgaa ccgcctcgcg gcggccgccg ccgaccggca ggacatactg 3360
ctcgacctgg tacgcgacac cgtcgccacg gtcctcggcc tgtcgaacgc cgaacactgt 3420
gcgccggacc ggacgttccg cgagaacggc ctcgactccc tcaccaccgt cgaattcgcg 3480
aacatcgtcg ccgcccggac aggcctgcgc gttcccgcgt ccacggcgtt cgaccacccc 3540
actccgcgtg cgttcgccgc gcacctcgcc ggggccacaa cggcggcgcc cgccccggcc 3600
cggaccgtcg gccccggtga acccatcgcg atcgtcggca tggcctgccg actgccgggc 3660
ggcgtcgcat cgccggagga actatggcgg ctcgtcgaat ccgggggcga cgccatcacc 3720
gagttccccg ccgaccgcgg ctgggaagtc gagtcgctgt acgaccccga cccggacgcg 3780
gccggacggt cgacgacccg ccacggcggc ttcctcaccg gggcgaccgg gttcgacacc 3840
gcgttcttcg ggatcagccc gaacgaggcc ctggccatgg acccgcagca gcgcctggtc 3900
ctggagacgt catgggaggc gttcgaacac gcgggcatcg tgccggacac gctcagggac 3960
agcgacaccg gcgtgttcat gggcgccttc caccaggggt acggcgcagg ccgcgacctg 4020
ggcggactcg gtgtcacggc aatccagacg agcgttctgt ccggacgtct ctcgtacttc 4080
tacgggttcc agggcccggc ggtcacggtc gatacggcgt gctcgtcgtc gctggtcgcc 4140
ctgcaccaag cggtacaggc gctgcgcagc ggcgagtgct ccctcgccct gaccggcggg 4200
gtcaccgtga tggcgacccc gcagagcttc gtggagttct cccgtcagcg cgggctcgct 4260
ccggacggcc ggtgcaaggc gttcgccgac acggccgacg gaacggggtt ctccgaaggc 4320
gtcggtgttc tggtggtgga gcggctgtcg gacgcggagc gcaacggtca cacggtgctt 4380
gcggtgattc gcggtacggc ggtgaaccag gacggtgcgt ccaacggcct ctccgcgccc 4440
aacggtgtag cacagcagcg cgtcatccgg caggcactcg ccagcgccgg gttgagcggg 4500
tccgatgtgc aggccgtcga ggcgcatggg acggggacgg tgttggggga tccgattgag 4560
gcgcaggcgg ttattgcggt gtatgggcag gggcgtgagg tgccgctgta tttaggttcg 4620
ttgaagtcga atattggtca tgcgcaggcg gcggctggtg tggccggtgt gatcaagatg 4680
gtgatggcga tgcggtacgg ggtgctgccg aggaccttgc acgtcggtga gcggtcgtcg 4740
catgtggact ggtcggcggg ggcggtggag gtgttgtcgg aggcgaggcc gtggccggag 4800
ttggggcgtg cgcggcgggc gggggtgtcg gggttcgggg tgagtgggac gaatgcgcat 4860
gtggtgttgg agggggtgcc ggaggtttcg gtctctccca cagagtcgtc cggtggtttg 4920
ttgccattgc cggtgtcggc tcgttcgggt gtgggtgtgg gtgtgttggt ggagcgggtg 4980
ggtgggttgg tggggggtgg gtgtgatgtg ggtgtggtgg cggatgggtt ggtgcggggg 5040
cgtgcggtgt tcggtcatcg ggcggtgctg ttgggggaga gcagggttat gggtgtggcg 5100
ggtgaggggt tgcggacggt gttcgtgttc ccggggcagg ggtcgcagtg ggtgggaatg 5160
ggccgcgaac ttgctgaagt gtcacctgtc tttgcggcgc ggatgggtga gtgtgcggcg 5220
gcgttggcac ctcatgtgga ctggtcgtgg gaggaggcgt tggggtcggc ggagttgctg 5280
gggcgggtgg aggtggtgca gccgttgtcg tgggcggtgg cggtgagtct ggcggcgctg 5340
tggggggcgc atggtgtggt gccggatgtg gtggtggggc attcgcaggg ggagattgct 5400
gcggcgtgtg tggcgggtgc gctgagtttg gaggacgggg cgcgggtggt ggctttgcgc 5460
agccgggtga tcggtgcccg gctggcgggg cggggggtga tggcatcggt cgcactcccc 5520
gccgccgaca tcgagacggt ggagggggtg tggatcgcgg cccgtaacgg accgtcgtcg 5580
accgtgatcg cgggagatgc gcaggcggtg gagggggttc tggcccggta cgagagcaca 5640
ggagtacggg ttcggcggat cgcggtcgac tacgcctccc acacccccca cgtcgaggcc 5700
atcgaggacg agctggccga ggtgctggaa ggcgtaacca cccgtactcc tgtgatccct 5760
tggtggtcca cggtcgacag cggctgggtg gaggagccgg tcgacgacgg ctactggtac 5820
cgcaacctcc gtcaaccggt agccctggac accgccatca cagaactcga cggctccctc 5880
ttcgtcgagt gcagcgccca tccggtgctg ctgcccgcca tcgaccagca acgtaccgtc 5940
gcgtcactcc gcaccgacga cggcggcgga gaccggttca ccaccgccct ggcggaggcc 6000
tgggtccacg gcgcggccgt cgactggacc accatcgtcc cgcccacccc ggaacgactc 6060
ctcgacctcc ccacctaccc cttcgaccac aagcgctact ggctgcctcc cgccccggca 6120
ggcggcagcg agggcatcgg gcatccgttt ctgtcgagcg tggtggccct gccgggcagc 6180
gacggcgttc tgctgaaggg cagggtgtca ctcgccgcgc acccctggct ggccgaccac 6240
gccgttcgcg acacggtact tctcccgggt accgcgttcc tggagctggt gatccgcgcc 6300
ggtgacgaga ccggctgcga caccatcgac gagctggtca tcgaaacacc gctcgccctt 6360
ccggtcaccg gtgccgtcga cctcaccgtc accgtcgacc ggcccgacga ggccggacgc 6420
cgccccgtga ccgtccacgc ccgcctccag ggaaccggca cctggacccg ccacgccacc 6480
ggaaccctca ccaccggcac caagcggacc accgatgccc cggacccgta caccttggcg 6540
cagtggcccc cggccggagc gcaaccggca agcctggacc ggttctacga gcaactggcg 6600
gcagcgggct acacctacgg tccggcgttc caggggctgc gcgctgcatg gacggcgggc 6660
gacacgatct acgccgaagc cgctctggac agcgccgaag aggtggaccg cttcggggtt 6720
cacccggcgc tcctggacgc ggccctgcac gccggacgcc tcgacgcggg cgacgcattg 6780
gagcttccgt tctcctggac gggtgtgcgc ctgcacgccg gtggggccac cgcggtgcgc 6840
gtcgctctca tccggggccc ggggggcgtc accgtgcaga tggccgatcc ggacggtcgt 6900
cccgtcgtca ccgtagacgc gctggtacta cgaccgggta ccggcacgcc gtcgggaccg 6960
aagctcctcg ggttggagtg ggtgccggtg gcggaagccg tctacgacgg gaccctcccc 7020
gacggctaca ccctcatcac cgccgcacac cccgacgagc cggacgacct caccgacctc 7080
accgatatgc ccgccctcac ccaagcccgc accacccgca ccctcaccgc cctccaacac 7140
cacctcacca ccacccacca caccctcatc gtccacacca ccaccgaccc cgcaggcgcc 7200
gcagccaccg gactcaccaa aaccgcccag aacgaacacc caaaccgcat ccacatcatc 7260
gaaaccaccc acccccacac acccctcccc ctccaccaga tcaccaccct caaccaaccc 7320
cacctccgcc tcacccacca caccctccac acaccccacc tcacccccct ccaccacacc 7380
cccaccccca caccacccct caacccccac cacgccatcc tcatcaccgg cggctccggc 7440
accctcgccg gaatcctcgc ccgccacctc aaccaccccc acacctacct cctctcccga 7500
acaccaccac cccccaccac ccccggcacc cacatcccct gcgacctcac cgacccccac 7560
caactcaccc aagccctcca ccacataccc caacccctca ccgccatcta ccacaccgca 7620
gccaccctca acgacgccac cctccacaac ctcacccccc accacctcac caccaccctc 7680
accaccaaag cccacaccgc ctggcacctc caccaacaaa cccaacacca ccccctcacc 7740
cacttcatcc tctactcctc agcagccgcc accctcggca gccccggaca agccaactac 7800
gccgccgcca acgccttcct cgacgccctc gccacccacc gccacaccca aggacaaccc 7860
gccaccacca tcgcctgggg catgtggcaa accaccacca acctcaccac ccaactcacc 7920
cacaccgacc gacagcgggt gcgcgacggg ttccggccgc tcaccgaggc ggagggcagg 7980
cacttcctcg acctgagcct cgccacggac gagccgttcg tgatcgcggc gatccccgcc 8040
gcacccgaat ccgtatccgt acccgaatcc gagcccgccc gccggcgcgt ggagcgcccc 8100
accgtccgta cgggcgagga ccgcggccgt gatctgctgg ccgtcgtgtg ttcggccacc 8160
gccgccgtgc tgggccaccc ggacgcctcc ggtatcgggc ccgcgaccgc gttcaaggat 8220
ctcggcatcg actcgctcag cggtatccgg ctgcgcaaca ggctcgccga gacgaccggc 8280
gtcaggctct ccgcgacggc cgtcttcgac catccgactc cggacgcgct cgccacgcag 8340
ctcgccgcgg ccctgcgcag tgccggagcg ccgccgggcg gtgcggagac cgcggccccg 8400
gcgcccgtac ccccgaaggc ggtggcgggg gacgaaccgc tggcgatcgt ggccatggcc 8460
tgccggatgc ccggcggtgc ggataccccg gaagacctgt ggaacctcgt cgaatccggt 8520
ggcgacggga tcaccgattt ccccaccgac cgcggctggg acctcgcggc gctctacgac 8580
ccggaccccg acgcgatcgg caaggtctcc gtgcgccacg gcgggttcct cgccggggcg 8640
gccgacttcg atgccgagtt cttcggcatc agcccgcgcg aggcgctggc gatggacccg 8700
cagcagcggc tgatcctcga agtgtcgtgg gaggcgttcg aacgggcggg catcctgccc 8760
gcgagcgtcc gcggcagcga cgccggggtg ttcatgggcg cgttcggcca ggggtacggt 8820
gccggtgtcg acctgggcgg cttcggggcg accggcacgc cgacgagcgt gctctccgga 8880
cggctctcct actacttcgg gttcgagggc ccctccgtca ccgtcgacac ggcctgctcg 8940
tcgtcgctgg tcgccctgca ccaggccgcg cggtcgctgc gctcggggga gtgttcgctc 9000
gcgctggtcg gcggggtcac cgtcatggcg acgacgacgg gattcgtcga gttctcccgt 9060
cagcgcgggc tcgcccccga cggccgggcc aaggcgttcg cggacaccgc cgacggcacc 9120
agcttctcgg aaggcgccgg tgtcctgatc gtcgagcggc tctccgacgc cacccgcctc 9180
ggccatcccg tgctcgccgt ggtgcgcggc tccgcggtca actccgacgg cgcttcgaac 9240
ggcctctccg ctccgaacgg tcccgcgcag cagcgcgtca tcgaacgtgc gctcgccgac 9300
gcgggcctcg caccgggcga ggtcgacgcc gtggaggcac acggcaccgg tacccgtctc 9360
ggcgacccta tcgaggccca ggcactggag gcggcgtacg gggccggccg cgagcgcccg 9420
ctgctcatcg gctcgctcaa gtcgaacatc ggccacaccc aggcggcggc cggtatcgcg 9480
ggtgtcatca agatggtgat ggcgatgcgg cacggcgtcc tgccgcgcac gctgtacgtg 9540
gacgaaccgt cccggcacgt cgactgggac ggcaacgtcc ggctgctgcg ccgcaacgag 9600
ccgtggccgg acaccggccg cgcccggcgc gcgggcgtct cgtcgttcgg catcagcggt 9660
gccaacgccc atgtggtgct ggagtccggc ccctccgccg ctcccggttc ctccgcgagt 9720
ctcggtccct ccgcgactct cggtctcccc gccgcccccg gcccctccac cgctcccgtg 9780
ccccccgccg ctcccgtacc gctccccgag gccgagacgc aggacgtgct gtggccggtt 9840
tcggcccgca cctcggacgg ggtgcgggac gtcgcggccc gtatggccgc cctcacggca 9900
agggcggccg cgatcgggca ttcgctcgcc accacccgca cggccatgcg ccaccgggcg 9960
gttgtcccgg cccgggacgc ggaggcgttc gcccgcggcg aggaagtgcc ggacgtggtg 10020
cggggaacgg ccgacatcac cgacccgcgc gccgtgttcg tgttcccggg ccagggctcc 10080
cagtgggccg gtatgggcgc cgaactgctc gcggccgaac ccgtcttcgc gcggcggctc 10140
ggtgagtgcg ccgcggccct cgccccgcac accggctggg acctcctcga cgtcatcacc 10200
caacggcccg gcgcgcccgc tctggaccgg gtcgatgtcg tgcagcccgc gtcgttcgcc 10260
ctgatggtgg ccctcgcgga gctgtggagc gtgcacgggg tcgccccggc cgcggtggtc 10320
gggcattccc agggggaggt cgccgcggcc tgcgtcgccg gggcgctcac cctcgacgac 10380
gccgcgaagg tcgtcgcgct gcgcagccgg ctcgtcgccg ccgaactcgc cgggcgagga 10440
ggcatggtcg cggtggcgcc cgcggacttc gacgccgccg cgtggacggg gcgcctggag 10500
gtcgccgcgg tcaacgggcc cgcgtcgatc gtcgtcgccg gagcggccga tgccgtagag 10560
gagttcctcg ccgccgcacc ccgtgcccgc cggatcgccg tcgactacgc gtcgcacacc 10620
gcgcacgtcg agacggtccg tcaagccctg ctcgacgccc tggccgacct caccccgcga 10680
gcaccggaga tcccgttctt ctccaccgtg gacggggagt ggctcgaccg gcccgccgac 10740
gccgcctact ggtacgacaa cgtgcgccgc cccgtccgct tcggcgtcgc gacgagccgc 10800
ctcgacgaac tcggctaccg cgtattcgtc gagaccagcc cgcacccggt cctcaccccc 10860
gcgctggagg acacgctcgc cgggcagccg aacacggtgg tggtcggcac gctgcggcgc 10920
ggcgagggcg ggccgcgccg cttcggcaag tcgctcgccg cgctctgggt ccggggcgta 10980
cccgtcacct ggtcgttcgg ggtgtcccgg agtgtgccgc tgcccacgta cccgttccgg 11040
cgcgaccgct actggatcga cgcggaaccg gccggcggct ccgggcatcc gctgctggcc 11100
tcgctggtcg accgtgccga cggcgaaggg gcgctcgcca ccgcgctgtt ctcggtacgc 11160
cgacagccct ggctcaccga ccacgaggtc gacgggcgga tcatcgtgcc cggctcggcg 11220
ctcgtggaac tccttgccga ggcgggcacc cggctcggta caccggcgat cgcggagctg 11280
acgatcgtcg taccgctggt ggtcgacgcc gacgcggcca cagaggtcca gttcacggtc 11340
ggctccgagg tgtccgggca gcggcccgta cgcctgcaca gccgtaccgg tacggggccg 11400
tggaccctgg tggccaccgg agcgctgagc gccgagaccc gcgaaccggc gacgcccgag 11460
tggcctcccc ccgatgccga cccggtcgac ccggcaggct tctacgacac gctgccgctc 11520
agctacgggc ccgctttccg cgccgtgacg gcgctgtggg ccggccgggg acgcgcctac 11580
gcgtcggtcc gcctcggtga acagctcacc gacgcccggt acggactgca ccccgtcctg 11640
ctcgacgcgg cactgcacgc cctcggcatg ctcttcgacg atccggagcg gcgcaggctc 11700
gcgttctcct ggaccggcgt acggatgtac acgcgcgccg ccaccgcgct gcgggtgctc 11760
ctcgaacgcg tcggcgccga cacgatccgg gtcctcgcca tggacgagca cggcgccccg 11820
gtcctcgaag cggacggtct gaccgtacgg ggcgcggagc ccggcaacga cgcgctgttc 11880
gaggtcgtct gggttcccgt gccggccgcg cccgtccccg gctggacgta tcacgccgat 11940
gtccccgaag gggatactcc cccggtcgtg gtccttccct tggagcccgg cgaccccggc 12000
gaccccggcg accccggcga ccccggcgac cccggcgacc gcggcggatc gcccggcgtc 12060
cgggcccggg agctgggccg cgatctgctc gcgacggtgc agacgtggct cgcggacccc 12120
cgccgggccg gttcccgcct cgtcgtggtc acccgcaccg gcgatcccgc gcaggaagcg 12180
ctcggcggtc tggtccgtac cgccgggacg gagaaccccg gccgcgtcgg cctgatcgaa 12240
gcggacgaga tcacgcccgc caccgtcgcg gccgggctcg ccgccggtga cgagccccgg 12300
gtccgggtcg ccggagggac ggtccgcgcc gctcgtctgc gccgtgtcgc cgcggccgcg 12360
ggagcctccg cgctgaccgg gggaaccgtc ctcgtcaccg gcggcaccgg cggcctcggc 12420
cgccttctcg tggaccatct gctcaccgtc cacgaggcag cggagatcgt cgtggcgtcc 12480
cgcggcggcc ggcccggcgg agcgcctgag gacgaccggg tgcggtacgc ggccgtggac 12540
gtcaccgacc gggacgcgct ggccgccctc gtcgacggca tctccggacg gctccgcgcc 12600
gtcgtgcaca tggccgggat cgtcgacgac gcggtcgtgg cgaccatgcg gccccaacag 12660
tgggacgacg tactgcgggt gaaggccgac gtcgcctggc acctgcacga actgacgcgc 12720
gacaccgaac tcgcggcgtt cgtcctgtac tcgtcgatct ccgcgacgtt cggcggggcg 12780
gggcaggcga actacgcgac cggcaacgcg ttcctcgacg cgctcgcccg ccaccggcgc 12840
gaccggggac tgcccgccgt ctccctcgcg tgggggctgt gggacgaggc ggacggcatg 12900
ggcggacggc tgacctccac cgacctcggc cgcatcgccc gcggcggcat gatcccgatg 12960
acggccgcgc aaggactcgc cctgttcgac gcggccctgc acagcgaccg cgccgcactc 13020
gtccccgtcc gcctcgacct cgccgccgtc gccgcggcgg atcacgtccc accgatcctc 13080
cgcgacctgg taccggccgc gcggcgcacg cccgcaccgg ccggctcgcg cgacatgctc 13140
gaactcgtca ggacgagtgc cgccgcggtc ctcggccatc gcgacgtgca cgccgtcgaa 13200
cccctgcgcg cgttcaaaga cgtgggcttc gactcactga ccggcgtcga gctgcgcaac 13260
cggctgaccg acgcgacggg tctgaccctg cccgccacac tcgtcttcga ccaccccaca 13320
ccgcaggcac tcgccgccca cctcgacgaa ctggccggta cccgggcggc cacccggcga 13380
cgtacaccga ccccggcccg ccgccacgac gaaccactgg cgatcgtggg catggcgtgc 13440
cgcctgccgg gcggggtcat gtcccccgac gatctgtggc ggctgctgga gtcgggcggc 13500
gacggcatca cggcattccc cgccgaccgc ggctgggacc tggaagcgct ctacgacccc 13560
gaccccgacc gtccgggcac gtccaccgtc cggcacggcg gattcctccc gggggcggcc 13620
cacttcgacg ccgcgttctt cgggatcagc ccgcgcgagg ccctcgcgat ggacccgcag 13680
cagcggatcg tcctggaaac gtcgtgggag gcgctcgaac acgcgggcat cgacgcgcac 13740
accctgcgcg gcagcgacac cggcgtgttc atcggcggct acttctacgg gtacggctcc 13800
ggctccgatc gcggcggatt cggcgccacc agcacccaga ccagtgtgct gtcgggccgc 13860
ctctcctact tctacggact ggagggcccg gcggtcacgg tcgacacggc gtgctcgtcg 13920
tcgctggtcg cgctgcatca ggccggtcag tcgctgcgta ccggggaatg ctccctggca 13980
ctggtcggcg gcgtcacggt gatggcctcg ccgtccggtt tcgtcgactt ctcccagcag 14040
cgcggtctcg cctcggacgg ccggtgcaag gccttcgcgg acgccgcgga cggtaccgcc 14100
ttcgcggagg gttccggtgt gctggtggtg gagcggcttt ccgatgccga acgcctcggc 14160
caccgcgtcc tcgcggtcgt acgcggctcc gccgtcaacc aggacggcgc ctccaacgga 14220
ctctccgcac ccaacggacc ctcccaggaa cgtgtcatcc ggcaagccct cgccaatgcg 14280
cggctcgaac cttccgacgt cgacgccgtg gaagcgcacg gcaccggcac ccgcctcggt 14340
gaccccatcg aagccagggc gcttctggag acgtacggac aggaccgtac ggcgccgctc 14400
ctcctcggct ccctgaagtc caacatcggc cacacccagg ccgccgcggg cgtcgcgggc 14460
atcatcaaaa tggtcctggc gatgcgccac ggcaccctgc ccccgacgct ccacgtcgac 14520
cggcccacca cccacgtcga ctggtcggca ggcagcatcg aactcctcac cgaacccagg 14580
ccctggcccg ataccggccg gccccggcgg gccgccgtct cctccttcgg cgtcagcggc 14640
accaacgccc acgtcatcct cgaaagccgc ccccagccgg aagccgagac cccgcccggc 14700
gcccaccccg cacccctgct gatctccgcc cgcacccccc gcgccctcca tgaacacacc 14760
acccgcatcc gggccttccg cgactccgga agctgcgacg aacacgccgt ggcctcggcc 14820
ctgctcgccc gtacggcctt ccggcaccgg gcggccctca tcggcacgga cctgatcacc 14880
ggcaccgccg aaccggaccg ccgcctggtg tggctctact ccgggcaggg ctcgcaacgc 14940
cccggcatgg gcgacgaact ggccgccgcg tacgacgtgt tcgcccgcac ccgccgtgac 15000
gtcctcgacg ccctccgggt gcccaccgga ctcgacctcc acgacaccgg atacgcccag 15060
ccttcggtct tcgccctcca agtcgcgctc agcgcccagc tcgacacctg gggcgtacgc 15120
ccggacgtcc tcgtgggcca ctccatcggc gagctggccg cggcgtacgt cgccggtgtc 15180
tggtccctcg acgacgcgtg caccctggtc gcggcgcgcg cccggctgat gcaggccctg 15240
ccgcacggcg gcgcgatggc cgccgtcgtc gcgtccgagc aggaggcgca gccgctgctg 15300
cgcgacggcg tggagatcgc cgcggtcaac ggcccctcgt cgatcgtcct ctccggtgac 15360
gaggccacgg tgctcgacac cgcggcccga ctcggccgct tcacccgcct gcggaccagc 15420
cacgccttcc attcggcccg gatggaaccg atgctcgacg cgttccggga ggtcgcggag 15480
gggctgacgt accacgagcc gaagattccg atggccgcgg gcgccgagtg cgcgacaccg 15540
gagtactggg tgcggcaggt ccgcgacacc gtccggttcg gagagcagat cgccgcgtac 15600
gacggggcgc tgctcctgga ggtcggcccg gaccgcaatc tgtcccgcct cgtcgacggc 15660
atcccgatgc tgcacggcga cgacgagccc cggtccgcga tgaccgcgct cgcccgcctc 15720
cacaccagtg gtgccacggt cgactggccg aaggtcatcg gccccgcgcc ggcctcgccg 15780
ccggacctgc cgacgtaccc gttcgcgcgg gaccgctact ggtcggcgtc ccgcggcagc 15840
ggcgatacgg cccccgcggg tcagctgccc gtcgaccacc cggtgctgac cgcggcggtc 15900
agtattcccg gcagcggtga actggtcctc accggccgcg tcgacgccgc cgatccactg 15960
gcgcactccg tgcacggcat cgcggtactc ccggccgccg tcctcgtcga cctggcggtc 16020
accgcgggcg acgaagccgg ctgcggtgtt ctggagacct tcgccgtgga caccccgctg 16080
gtgcttccgc agtccggcgg ggccgcgctc tccgtcaccg tcgcggcgcc ccgggaagac 16140
ggccgccgca cggtcaccgt gcatgcccgg cacggcaacg gcgagtggac cgggcacgcc 16200
accggaatcc tcgccgccga agccccggcc ccggccccgg ccttggcagc accgtcggtg 16260
tggccgcccg cgacggcccg cccgttggat gtcggagagc aggcggacgc cctggccagg 16320
gccggtcaca cgggcggccc cgcgcagccc cggccgcacg cggcctggac cgacgagggc 16380
gccgtctacg ccgaagtgtc cctcgccgaa gaccggctgt ccgaagccgg gcgctacgga 16440
ctgcacccgg ctctgctcgg cgccgcgctc accctcgccg cggcggggac cgatcttccg 16500
tacgccttcg acgacgtgcg cgtccacacc ggcggagcca ccgcggtacg ggtcgccgtc 16560
accgcccacg gcgtacacat cacggacggg accgggaggc ccgtcgccac cgtcggcgcc 16620
gtccgcagcc gccccctgac cgtcgaagga gccgttccgg gcctgctgcg acccgtactg 16680
gcagagccgg ccgagataca ggaaccgccc cccaccaccg cgacgaccgg tggactcgac 16740
gacccgacgg tcccggacgt cgtgatcctt cccgcgtacg ggaccggggg cgccccgctc 16800
gacgaggtac ggcgcctcgg ggccgaggtg ctggccgcgc tgcagcgctt cctcaccgac 16860
gaccggtacg ccgaggcggt gctcgccgtc cacaccgggc ccggcctcgc cgccgcggcc 16920
gtcgcgggcc tcgtacgaac cgcgcaggcg gagcaccccg gccggatcgc cctcgtcgac 16980
gccgcaccgg acaccgccgc cccgctgctg gcggcggccg ccgtcctcgg tgaaccacag 17040
accgtgctgc gcgacggccg gacctatccg cgcaggctca ccccggcggc cccggccggt 17100
gacgctcccg cactcgaccc ggacggcacg gtcctcatca ccggagggtc cggaacactg 17160
gcgggcatca tcgcccggca cctcgtcgac cactacggag tacgccggct gctgatgctg 17220
tcccgcggcg gcacggcgaa cgacgtcccg ggcgcccatg tcacggccgt cgcctgcgat 17280
atcgcgaacc gggacgagct ggtatcggca ctggcgggga tcgaccccgc acaccccctg 17340
accgccgtgg tgcacaccgc ggccgtcatc gacgacggag tcctcaccgg actcacgccg 17400
gagcgtctcg acaccgtcct gcgcccgaag gccgacggcg cctggcacct gcacgaactc 17460
accaaggacc aggacctcgc ggcgttcgtg ctctactcct cggccgccgg ggtgctcggc 17520
agccccggcc agggcaacta cgcggcagcg aacgcgttcc tcgacgaact cgccgtacag 17580
cgccgggcca ccggactgcc cgccctgtcg ttggcctggg gcctgtggga gccggagagc 17640
ggactgacgg ccggggccgg cgaccgcctg cgccgatccg gcgtcacggc actgagcacc 17700
gaacgcggac tggcgctctt cgacgcggcc ctgcggtccc cggacgcggc gctcgtcgcc 17760
gccgacccgg cggggctcgg tgatacgccc ctcctcaggg cagcgggcag ggtcccccgg 17820
cgccgtacgg ccggtgccgg agcgctcgcg gaccggatcg ccggactctc cgcggccgaa 17880
gcggagaagg tcgcgctcgc cgtcgtccgg gagtgcgcgg cggccgtgct cggccacgac 17940
ggcgccgacc ggatcgaacc gaccgcgacc ttcaaggaac tcggcgccga ctccctcacg 18000
gcggtccggc tgcgcaacgc gctcaccgag gcgacaggtg tacggctccc cgcgaccgcg 18060
gtcttcgact tcccgacgcc gcaagccgtc gcggcgaagc tgaccaccgc cctgtccggc 18120
cgcccggcgg agcccacccg cgcgccgacc ccggccatgg cagtcgacga accgctggcg 18180
atcgtgggca tggcctgccg gctgccgggc ggggtcgcgt cacccgacgg tctgtggcgg 18240
ctgctggagt ccggtggcga gggcatcacg gcgttccccg ccgaccgcgg ctgggacgtg 18300
gacgcgctct acgatcccga ccccgggcat ccgggcacgt ccacggtccg gcacggcggg 18360
ttcctcccgg gggcggccga cttcgacgcc gcgttcttcg ggatcagccc gcgtgaggcc 18420
ctcgcgatgg acccgcagca gcggatcgtc ctggaaacgt cgtgggaggc gctggaacag 18480
gcgggcatcg tccccggaac gctccgcggc agcgacaccg gtgtgttcat cggcgcgttc 18540
tccgacgggt acggcctcgg caccgacctc ggcggattcg gcgccaccgg aacccagacc 18600
agtgtgctgt cgggccgtct ctcgtacttc tacggtctgg agggcccggc ggtcacggtc 18660
gacacggcgt gttcgtcgtc gctggtcgcg ctgcaccagg ccggtcagtc gctgcgtacc 18720
ggggagtgtt ctctggcact ggtcggcggt gtcacggtga tggcctcgcc gtccggtttc 18780
gtcgagttct cccagcagcg gggcctcgcc tcggacggcc ggtgcaaggc cttcgcggac 18840
gccgcggacg gtaccgcctt cgcggagggt tccggtgtgc tggtggtgga gcggctttcc 18900
gatgccgagc ggctcggcca tcgtgttctc gcggtcgtac gcggctccgc cgtcaaccag 18960
gacggcgcct ccaacggact ctccgcaccc aacggaccct cccaggaacg cgtcatccgg 19020
caagccctcg cgaacgcgcg gctcgaacct tccgacgtcg acgcggtcga agcacacggc 19080
accggcaccc gcctcgggga ccccatcgaa gcgaccgcgc tcctcgcgac ctacggacag 19140
agccgcacca caccgctcct cctcggctcc ctgaagtcca acatcggcca cacccaggcc 19200
gccgcgggcg tcgcgggcat catcaaaatg gtcctcgcca tgcaccacgg caccctgccc 19260
cgcaccctgc acgtcgacac accgtcgtcg cacgtcgact ggacggcggg aggagtcgaa 19320
ctcctcaccg aagcccggcc ctggcccggg acgagccggc cccggcgggc cgccgtctcc 19380
tccttcggcg tcagcggcac caacgcccac gtcatcctcg aagcccccgc ggctccggat 19440
tcaccgtccg cagcttcacc gtccgtggcg ccccgcgaac cgctgttcct cacggagcgc 19500
accccgctcc cggtctcggc ccgtaccccc gaggccgtcg aaggccagat ccaacggctc 19560
cgcgcacacc tggccgaaca ccccggcgac gacccgcgta ccgtcgccgc cgcgctgttc 19620
tccacccgca ccgagttccc gcaccgcgcc gtgctcctcg gcgaaggcgc tgtcaccggc 19680
acggcgctca cccggccgcg tacggtcttc gtcttccccg gacaaggctc ccagtggctc 19740
ggcatgggcc tgaaactgat ggccgagtca ccggtgttcg cggcccggat gagggagtgc 19800
gcggacgcgc tcgccgaaca cacgggccgc gacctgatcg ccatgctcga agacccggcc 19860
gtgaaaagcc gcgtcgacgt cgtccacccc gtctgctggg cggtcatgat gtccctggcc 19920
gccgtgtggg aggccgcggg ggtacgtccg gacgccgtca tcggccactc ccagggggag 19980
atcgccgcgg cctgtgtcgc cggggcgatc acactggagg acggtgcccg gctcgtcgcg 20040
ctccgctccg ccctgctcca gcgcgaactc gccggacacg gcgcgatggg ttcgatcgcg 20100
ttccccgccg ccgacgtcga ggcggccgcc gcacaggtcg acaacgtctg ggtcgcgggc 20160
cgcaacggca ccggcaccac gatcgtgtcc gggcggcccg acgccgtcga aacgctgatc 20220
gcccgctacg aggcccgagg cgtctgggtg acccgcctcg tcgtcgactg cccgacccac 20280
accccgttcg tcgacccgct gtacgacgag ttccagcgga tcgccgcggc caccacctcc 20340
cgtacgcccc gaatcccctg gttctccacc gccgacgagc ggtggatcga ctccccgctg 20400
gacgacgagt actggttccg caatctgcgc aatcccgttg gtttcgccgc cgccgtggcc 20460
gccgcccgcg agccgggtga caccgtcttc gtcgaggtca gcgcccaccc ggtactgctg 20520
cccgcgatca acggcacaac cgtcggcacg ctgcgccgcg gcggaggggc cgaccaggtc 20580
gtcgactcgc tggccaaggc gtacacggcc ggtgtggccg tcgactggcc gaccgtcgtc 20640
gcggcaccgg ggacggcaca cgacaccaca aggacggcat ccggacccgt cccgggaccg 20700
gcacacgacc tgccgacgta cgccttccac cacgagcgct actggatcga accgtcatcc 20760
ggtacggacg ccaccggcct cggactcgac gccgtggacc acccgctgct cgccgcgtcc 20820
gtggccctgc ccgacaccga cgagacgctg ctcaccggcc gtttctccct cgccacccac 20880
ccgtggctcg ccgggcactc cgtcgcgggc gaagtgctgc tgcccggacc ggtgttcgtg 20940
gagctggccg ggcgcgccgc cgacgagacg ggctgcgacc tgctcgacga actggtcatc 21000
gagacccccc tggcgctgcc cgcgaccggc gccgtacagg tccgcgtgac cgtcgccgca 21060
gccgacgacg gcggacgccg cgccgtgcgc atccacgccc ggaaagacgg ggacgggacg 21120
tggacccgtc atgcctcggg ccgggccggt atcgccaccg ccgagccggc cacgaccgac 21180
ggcccctggc cgcccgcgca cgccgagcag ctcgacaccg cggagttcta ccgaaggctc 21240
gacgacgagg ggtacgggtt cggccccggg ttccgaggcc tgtccgcggc atggcgacac 21300
ggtgacaccg tcttcgcgga ggtggccgtc gacggcgccc tcgccaggga cgcctcccgc 21360
tacaccctgc acccggcgct gctcgtcacc gcgctccagg cgggcagcct gagcgcgggc 21420
tccgaggacg cgggggtccg ggtcccgttc gcgttctccg gtgtacgggt ccattcgagc 21480
ggcgccacga aggcgcgggt caccttcacc gccgccgacg gcggtgcccg cgtccatctc 21540
gccgacgaga cgggacggcc ggtcgcggag atcgggtcac tcgtcacccg gccccccgcc 21600
accccggatc cgggcggaga cgtacgcctg taccggcgta cctggaccgg tgtcagggcg 21660
cccgcggcac ccggcaccac cgccgtcaga tacccggacc cgggcgacgg caccgcgccc 21720
gggggcgacc cgttcgacac gacccgcccc gatgtcctcg tggtcagggc gtccgatccc 21780
gcggacgtac gcaccgcgct cgacgacccg aggacggccg gcgccacgct ggtcgtgtcc 21840
gcggccgccg gaaccactgc cggtgccgtc gcggcgctgg tcgacacctc accacccgga 21900
cggatcgtgc tggtgcagac cgccgacacg atcacacccc gccgcgccgc ggccttcgcc 21960
cgcctcgacg aaccgcacct caggctcacc ggtggacgcc tcgaagcacc acgcctggtc 22020
ccggccccgc cccgcaccga tccacccccg tacggcggcg tcgtgctcct cgccggtggg 22080
tcggacgacc tcgcccggca gctgaccggg cagggagccg aggtgatccg ccatgagccg 22140
ggcaggctgc ccgggtcccc ggtgaccgcg gtcgtccacg cggcaggcac cgccgagtcg 22200
gcgtgggaac tgcaccggct cacccgcgaa ctcccgctgg acgcgttcgt cctgctcgtt 22260
ccgcccgggg aggcggcagg gccgtgggaa gccctcgccg aactgcgccg ggcagaaggg 22320
ctgcccgcca tggcgttcac ggccgccgag gaccggcaga ccgaactgct cgacgcggca 22380
cgcgccaccg gagaggccgt ggtcgtggcg accgccccac ccccgcccgg tgacccgtca 22440
ccgctgtggc ggccggtccg gcggcccacc cggcgcgccg ccgcaagcgg cggcaccctg 22500
ccggagcgac tgccggacct gtcgcccgaa gaacaggagc aggcagtact cgggctggtt 22560
cgcgacaccg cggccgcact gctcggccac gccgacgccc gggcggtcac ggccaccgcg 22620
gccttcaagg acctcggggt cgactccctc accgcactcg gcctgcgaga ccgcctggcc 22680
gaagccctcg ccaccccact gccggccacc ctcgtcttcg actatccggc ggccgggaca 22740
ctcacccgcc acctgctcac gctcctgaac ccggatggca gcgcgaccca ggacggcggt 22800
gaaccgccgg tggcgcggac gcccgagaac cctcaggcgg cggagcccga caacaagtcg 22860
atcgacgacg agttgctcga cgaggagttg atcgacgaca tggacgccga cgcgctcatc 22920
gcgcatgtac ggaagggatg a 22941
<210> 36
<211> 330
<212> PRT
<213> Streptomyces sp. GT1005
<400> 36
Val Pro Val Ala Ala Pro Tyr Cys Arg Phe Glu Lys Leu Val Pro Ser
1 5 10 15
Asp Leu Glu Gly Asp Glu Thr Val Leu Gly Val Ile Glu His Gly Thr
20 25 30
Gly His Ala Glu Val Ser Leu Thr Asp Gly Val Pro Arg Ala Ala Val
35 40 45
His Thr Thr Thr Phe Glu Glu Glu Ala Phe Ala Glu Val Trp Arg Ala
50 55 60
Gln Pro Pro Val Glu Ser Gly Arg Asp Gly Gly Ile Ala Trp Ala Arg
65 70 75 80
Thr Asp Glu Tyr Leu Phe Gly Val Gly Arg Val Pro Glu Ser Arg Gly
85 90 95
Tyr Ala Asp Ala Val Ala Ala Leu Tyr Thr Arg Val Phe Gly Leu Thr
100 105 110
Arg Ser Leu Gly His Pro Leu Leu Ala Arg Thr Trp Asn Tyr Ile Ser
115 120 125
Gly Ile Asn Ala Ala Asn Ala Asp Gly Leu Glu Val Tyr Arg Asp Phe
130 135 140
Cys Val Gly Arg Ala Gln Ala Leu Asp Ala Gly Gly Ile Asp Pro Ala
145 150 155 160
Gly Leu Pro Ala Ala Thr Gly Ile Gly Thr His Gly Gly Gly Ile Thr
165 170 175
Cys Val Phe Leu Ala Ala Arg Gly Gly Thr Arg Ile Asn Ile Glu Asn
180 185 190
Pro Ala Val Leu Thr Ala His His Tyr Pro Thr Ala Tyr Gly Pro Arg
195 200 205
Pro Pro Val Phe Ala Arg Ala Thr Trp Leu Gly Pro Pro Gly Asp Gly
210 215 220
Arg Leu Phe Val Ser Ala Thr Ala Gly Ile Leu Gly His Glu Thr Thr
225 230 235 240
His His Gly Asp Val Thr Gly Gln Cys Glu Val Ala Leu Asp Asn Ile
245 250 255
Ala Arg Val Val Ala Ala Glu Asn Leu His Arg His Gly Val Arg Arg
260 265 270
Gly Tyr Ala Leu Thr Asp Val Asp His Leu Lys Val Tyr Val Arg Arg
275 280 285
Arg Ala Asp Leu Pro Ala Val Arg Arg Val Cys Ala Ala Arg Leu Ala
290 295 300
Ser Thr Ala Thr Val Ala Phe Leu His Thr Asp Ile Ala Arg Gly Asp
305 310 315 320
Leu Leu Val Glu Ile Glu Gly Val Val Ser
325 330
<210> 37
<211> 993
<212> DNA
<213> Streptomyces sp. GT1005
<400> 37
gtgcctgtcg cggcaccgta ctgccgcttc gagaagctcg tgccgtcgga cctcgaaggg 60
gacgagaccg tgctcggcgt catcgagcac ggcaccggtc atgccgaggt gtcgctcacg 120
gacggtgtcc cgcgtgccgc ggtgcacacc acgaccttcg aggaggaggc gttcgccgag 180
gtgtggcgcg cgcagccgcc cgtcgagtcc ggccgggacg gaggcatcgc atgggcccgc 240
accgacgagt acctgttcgg tgtcggccgc gtccccgaga gccgggggta cgccgatgcc 300
gtcgcggcgc tctacacgcg ggtcttcggg ctgacccggt ccctgggaca tccgctgctc 360
gcccggacgt ggaactacat cagtgggatc aacgcggcga acgcggacgg gctggaggtg 420
taccgggact tctgcgtggg ccgtgcgcag gcgctggacg cgggcgggat cgacccggcc 480
ggcctgcccg cggccaccgg catcggcacg cacgggggtg gtatcacctg cgtgttcctc 540
gccgcccgcg gcggaacccg gatcaacatc gagaaccctg ccgtcctcac ggcacaccac 600
taccccacgg cgtacggccc gcgccccccg gtcttcgcac gggccacctg gctgggcccg 660
ccgggcgacg gccggctgtt cgtgtccgcg acggccggaa tcctcgggca cgagaccacg 720
caccacggtg atgtgaccgg tcagtgcgag gtcgccctgg acaacatcgc ccgggtcgtg 780
gccgccgaga acctgcaccg gcacggtgtc cggcggggtt acgccctcac cgacgtcgat 840
cacctcaagg tctacgtccg gcgccgcgcg gacctccccg cggtccgccg ggtctgcgcc 900
gcccgcttgg cgagcaccgc gaccgtcgcg tttctgcaca ccgacatcgc ccgtggcgac 960
ctgctcgtgg agatcgaagg agtggtgtcg tga 993
<210> 38
<211> 1532
<212> PRT
<213> Streptomyces sp. GT1005
<400> 38
Val Thr Pro Asp Gly Lys Arg Pro Gly Thr Leu Arg Leu Gly Gly Ser
1 5 10 15
Thr Lys Asn Arg Gly Ser Gln Gly Asn Gly Glu Thr Arg Glu Ser Arg
20 25 30
Glu Asn Gln Gly Ser Arg Lys Asp Gln Gly Asn Arg Gly Asn Arg His
35 40 45
Arg Glu Ile Gly Thr Ala Asn Arg Ser Glu Pro Leu Leu Thr Ser Phe
50 55 60
Ser Gln Arg Arg Ile Trp Phe Leu Gln Glu Leu Asp Pro Asp Ser Asn
65 70 75 80
Ala Tyr Asn Leu Pro Leu Val Leu Arg Leu Ser Gly Pro Leu Asp Ala
85 90 95
Ala Leu Leu Glu Arg Ala Leu Ala Leu Val Val Ala Arg His Glu Ala
100 105 110
Leu Arg Thr Val Phe Asp Ala Ala Asp Gly Glu Pro Val Gln Arg Val
115 120 125
Leu Pro Pro Ser Pro Arg Ile Leu Arg Arg Ser Arg Ala Ala Asp Asp
130 135 140
Arg Asp Ala Ala Arg Leu Val Arg Asp Glu Ile Ala Ala Pro Phe Asp
145 150 155 160
Leu Ser Thr Gly Pro Leu Ile Arg Ala Leu Leu Ile Arg Val Asp Asp
165 170 175
Gly Arg His Val Leu Ala Val Val Val His His Ile Ala Cys Asp Gly
180 185 190
Trp Ser Phe Gly Ile Leu Gln Leu Glu Leu Ala Ala His Tyr Ser Ala
195 200 205
Leu Arg Asp Thr Ser Arg Pro Ala Val Leu Pro Pro Leu Ser Leu Gln
210 215 220
Tyr Ala Asp Phe Ala Ala Trp Glu Arg Ser Glu Leu Thr Gly Ala Gly
225 230 235 240
Leu Glu Glu Arg Leu Ala His Trp Arg His Arg Leu Gln Asp Ala Pro
245 250 255
Pro Val Leu Arg Leu Pro Ser Asp Arg Pro Arg Pro Ala Val Ala Ala
260 265 270
Pro Asp Ala Gly Met Val Glu Trp Arg Pro Pro Asp Ala Leu Thr Ser
275 280 285
Ala Val Leu Arg Leu Gly His Asp Ala Gly Thr Thr Val Phe Met Thr
290 295 300
Leu Leu Ser Ala Phe Gln Ile Val Leu Ala Arg His Ala Gly Thr Leu
305 310 315 320
Asp Val Val Val Gly Thr Pro Val Ala Asn Arg Thr Arg Ala Ala Leu
325 330 335
Glu Gly Leu Ile Gly Met Phe Val Asn Thr Leu Ala Leu Arg Gly Asp
340 345 350
Leu Ser Gly Asp Pro Thr Phe Arg Glu Leu Leu Gly Arg Cys Arg Ala
355 360 365
Met Ala Thr Asp Ala Phe Ala His Ala Asp Leu Pro Phe Glu Asn Leu
370 375 380
Ile Glu Val Val Ala Pro Asp Arg Asp Leu Ser Val Asn Pro Val Val
385 390 395 400
Gln Val Leu Leu Gln Val Leu Arg Arg Asp Thr Thr Thr Ala Ala Leu
405 410 415
Pro Gly Val Thr Ala Glu Pro Phe Ser Ala Gly Arg Trp Phe Thr Arg
420 425 430
Phe Asp Leu Glu Phe His Val Tyr Glu Glu Ala Gly Gly Thr Leu Ala
435 440 445
Gly Glu Leu Leu Tyr Ser Arg Ala Leu Phe Asp Glu Pro Arg Ile Thr
450 455 460
Gly Leu Leu Asp Glu Phe Thr Ala Val Leu Arg Ala Val Thr Ala Asp
465 470 475 480
Pro Asp Val Arg Leu Ser Gly Leu Pro Ala Gly Asp Ala Gly Thr Ala
485 490 495
Pro Ala Pro Val Val Pro Ser Asn Asp Thr Ala Arg Ala Leu Pro Val
500 505 510
Glu Thr Leu Pro Glu Leu Leu Ala Arg Tyr Ala Ala Arg Thr Pro Asp
515 520 525
Ala Val Ala Val Thr Asp Pro Arg Thr Ser Leu Thr Tyr Ala Glu Leu
530 535 540
Asp Arg Arg Ala Asn Arg Leu Ala Gln Leu Leu Arg Ala Arg Gly Thr
545 550 555 560
Ala Thr Gly Asp Leu Val Gly Ile Cys Ala Asp Arg Gly Val Asp Leu
565 570 575
Val Val Gly Ile Val Gly Ile Leu Lys Ala Gly Ala Ala Tyr Val Pro
580 585 590
Leu Asp Pro Glu His Pro Ala Glu Arg Thr Ala Phe Val Leu Glu Asp
595 600 605
Ala Arg Leu Thr Thr Val Val Thr Asp Ser Ala Tyr Arg Pro Arg Phe
610 615 620
Pro Gly Val Pro His Val Val Thr Pro Asp Asp Pro Gln Leu Ala Arg
625 630 635 640
Gln Pro Asp Thr Ala Pro Arg Ile Val Leu Asp Arg Asp Ser Leu Ala
645 650 655
Tyr Ala Ile Tyr Thr Ser Gly Ser Thr Gly Lys Pro Lys Ala Val Leu
660 665 670
Met Pro Gly Val Ser Ala Val Asn Leu Leu Leu Trp Gln Glu Arg Thr
675 680 685
Met Gly Arg Glu Pro Ala Ser Arg Thr Val Gln Phe Val Thr Ser Thr
690 695 700
Phe Asp Tyr Ser Val Gln Glu Ile Phe Ser Ala Leu Leu Gly Gly Thr
705 710 715 720
Leu Val Ile Pro Pro Asp Glu Val Arg Leu Asp Pro Pro Gly Leu Ala
725 730 735
Arg Trp Met Asp Glu Gln Ala Ile Thr Arg Ile Tyr Ala Pro Thr Ala
740 745 750
Val Leu Arg Ala Leu Val Gly His Val Asp Pro His Ser Asp Gln Leu
755 760 765
Ser Ala Leu Arg His Leu Cys Gln Gly Gly Glu Ala Leu Val Leu Asp
770 775 780
Thr Arg Leu Arg Glu Leu Cys Arg His Arg Pro Arg Leu Arg Val His
785 790 795 800
Asn His Tyr Gly Pro Ala Glu Ser Gln Leu Ile Thr Ala Tyr Thr Leu
805 810 815
Pro Ser Asp Pro Gly Thr Trp Pro Ala Ala Ala Pro Ile Gly Pro Pro
820 825 830
Ile Asp Asn Thr Arg Ile His Leu Leu Asp Asp Ala Leu Arg Pro Val
835 840 845
Pro Asp Gly Met Pro Gly Gln Leu Cys Val Ala Gly Ile Gly Leu Ala
850 855 860
Arg Gly Tyr Leu Ala Arg Pro Gly Leu Thr Ala Glu Arg Trp Val Pro
865 870 875 880
Gly Gly Ala Thr Gly Glu Glu Arg Leu Tyr Leu Thr Gly Asp Leu Ala
885 890 895
Arg Arg Ala Pro Ser Gly Asp Leu Asp Phe Leu Gly Arg Ile Asp Asp
900 905 910
Gln Val Lys Ile Arg Gly Ile Arg Ile Glu Pro Gly Glu Ile Glu Asn
915 920 925
Ala Leu Ala Asp Asp Pro Arg Val Ala Asp Ala Ala Val Ser Val Arg
930 935 940
Glu Asp Pro Arg Gly Glu Lys Phe Leu Ala Ala Tyr Val Val Pro Ala
945 950 955 960
Gly Gly Pro Tyr Gly Asp Gly Phe Ala Ala Ser Leu Arg Asp Gly Leu
965 970 975
Ala Ala Arg Leu Pro Ala Tyr Leu Val Pro Ser Ser Val Val Thr Val
980 985 990
Ala Ala Leu Pro Arg Thr Thr Ser Gly Lys Val Asp Arg Arg Ala Leu
995 1000 1005
Pro Asp Pro Glu Pro Ala Arg Gly Ser Asp Arg Gln Ala Ala Pro
1010 1015 1020
Arg Thr Val Ala Glu Arg Val Val Cys Arg Ile Phe Gln Asp Val
1025 1030 1035
Leu Asp Val Pro Arg Val Gly Ala Asp Asp Asp Phe Phe Met Leu
1040 1045 1050
Gly Gly His Ser Leu Leu Ala Thr Arg Leu Val Ser Arg Ile Arg
1055 1060 1065
Ala Glu Phe Gly Val Asp Ile Ala Leu Arg Thr Leu Phe Asp Gly
1070 1075 1080
Arg Thr Pro Ala Ala Leu Ala Arg Ala Val Asp Thr Ala Gly Pro
1085 1090 1095
Ala Ala Val Pro Pro Pro Val Leu Ser Phe Pro Gly Ala Gly Pro
1100 1105 1110
Ala Pro Val Thr Ala Ala Gln Glu Gln Met Leu His Ser His Gly
1115 1120 1125
Ser Leu Leu Ala Ala Pro Ser Tyr Thr Val Ala Pro Tyr Gly Phe
1130 1135 1140
Arg Leu Tyr Gly Pro Leu Asp His Pro Ala Leu Asn Ala Ala Leu
1145 1150 1155
Thr Arg Ile Thr Ala Arg His Glu Pro Leu Arg Thr Gly Phe His
1160 1165 1170
Gly Arg Thr Gln Ile Val His Pro Pro Ala Glu Val Arg Ala Glu
1175 1180 1185
Val Val Glu Pro Val Pro Gly Gly Val Pro Asp Ala Val Arg Val
1190 1195 1200
Ala Arg Ala Glu Leu Thr Arg Pro Phe Asp Leu Val Asn Gly Pro
1205 1210 1215
Leu Leu Arg Ala Val Leu Leu Pro Leu Gly Thr Glu Asp His Val
1220 1225 1230
Leu Leu Leu Met Leu His His Leu Ala Gly Asp Gly Trp Ser Phe
1235 1240 1245
Asp Leu Leu Val Arg Glu Leu Ser Gly Ala Ser Pro Glu Leu Pro
1250 1255 1260
Val Ser Tyr Thr Asp Val Ala Arg Trp Glu Arg Thr Pro Glu Val
1265 1270 1275
Val Ala Ala Arg Asp Asn Asp Arg Ser Tyr Trp Arg Arg Gln Leu
1280 1285 1290
Glu Gly Ala Arg Ala Pro Glu Leu Pro Thr Ile Arg Pro Arg Gly
1295 1300 1305
Thr Thr Ala Ala Pro Asp Gly Arg Ala Phe Leu Trp Thr Leu Asp
1310 1315 1320
Asp Thr Thr Val Ala Ala Ala Arg Arg Ile Ser Gly Ala Arg Asn
1325 1330 1335
Ser Thr Leu Gln Glu Thr Val Leu Gly Ala Phe Ala Leu Val Val
1340 1345 1350
Ala Glu Ala Ala Gly Thr Asp Asp Leu Leu Val Thr Thr Pro Phe
1355 1360 1365
Ala Asp Arg Gly Gln Ala Gly Thr Glu His Leu Ile Gly Phe Phe
1370 1375 1380
Ala Lys Val Leu Ala Leu Arg Val Asp Val Gly Asp Gly Asn Gly
1385 1390 1395
Gly Thr Ala Ser Tyr Pro Glu Val Leu Arg Arg Val Gly Thr Ala
1400 1405 1410
Met Thr Gly Ala His Thr His Gln Ser Val Pro Tyr Ser Ala Met
1415 1420 1425
Arg Ala Ala Asp Pro Ala Leu Pro Pro Ala Pro Leu Ser Phe Gln
1430 1435 1440
Leu Ile Ser Ala Leu Ser Thr Glu Leu Arg Leu Pro Gly Leu Arg
1445 1450 1455
Thr Glu Pro Phe Pro Val Val Ala Glu Ser Val Asp Asp Ile Asn
1460 1465 1470
Gly Glu Leu Ser Val Asn Leu Phe Asp Asp Gly Arg Thr Val Ser
1475 1480 1485
Gly Ala Val Val His Asp Ala Ala Leu Leu Asp Arg Ala Ala Val
1490 1495 1500
Thr Asp Leu Leu Thr Arg Val Glu Ser Thr Leu Arg Ala Ala Ala
1505 1510 1515
Gly Asp Leu Thr Val Pro Val Thr Gly Pro Val Gly Ser Glu
1520 1525 1530
<210> 39
<211> 4599
<212> DNA
<213> Streptomyces sp. GT1005
<400> 39
gtgacaccgg acggcaagag gccggggacg ctccgtctcg gcggttccac aaagaatcgg 60
ggaagtcagg gaaacgggga aacccgggaa tcccgggaaa atcagggaag ccggaaagac 120
cagggaaacc ggggaaaccg gcatcgggaa atcggtaccg ccaaccgctc cgagccactc 180
ctcacctcgt tttcgcagcg gcgtatctgg tttctgcagg aactggatcc ggacagcaat 240
gcctacaatc ttccgctggt gctgcggctg agcggtccgc tcgacgcggc gctcctggag 300
cgggccctcg cgctcgtcgt ggcgcggcac gaggcgctgc ggaccgtgtt cgacgccgcg 360
gacggcgaac ccgtccagcg ggtgctgccg ccgtcgcccc ggatcctgcg ccggtcccgg 420
gcagccgacg accgggacgc ggcccggctc gtacgcgacg agatcgccgc gccgttcgat 480
ctctccaccg ggccgctgat cagggccctg ctgatccggg tggacgacgg ccggcacgtg 540
ctggcggtgg tcgtgcacca catcgcctgt gacggctggt cgttcgggat tctgcagctc 600
gaactcgcag cccactactc ggctctccgg gacacgtccc ggcccgccgt cctgccgccg 660
ctgtccctgc agtacgcaga cttcgccgcc tgggaacgat cggagctcac cggcgccggg 720
ctcgaagagc gcctggccca ctggcgccac cggctccagg acgccccgcc ggtgctccgt 780
ctgccgtccg accggccccg tcctgccgtc gccgccccgg acgcgggcat ggtcgagtgg 840
cggccgcccg acgcgctgac ctccgcggtg ctccggctgg ggcacgacgc cggtacgacg 900
gtgttcatga cgctgctctc ggcgttccag atcgtgctcg cccggcatgc gggcacgctg 960
gacgtggtgg tgggcacgcc cgtcgccaac cgcacccggg cggcgctcga aggcctcatc 1020
ggcatgttcg tcaacacgct cgcgctgcgc ggtgacctct ccggcgatcc cacgttccgg 1080
gagctcctcg gccgctgccg ggccatggcc acggacgcgt tcgcccacgc cgaccttccg 1140
ttcgagaacc tcatcgaggt cgtcgcaccg gatcgcgatc tgtcggtcaa tccggtcgtc 1200
caggtactgc tgcaggtcct cagacgcgat acgacgacgg ccgcgctgcc cggtgtgacc 1260
gccgagccct tctccgccgg gcgctggttc acccgcttcg atctggaatt ccatgtctac 1320
gaggaggccg gggggaccct cgccggagag ctgctgtaca gccgtgcgct gttcgacgaa 1380
ccccggatca cggggttgct cgacgagttc acggccgtgc tgcgggccgt cacggccgac 1440
ccggacgtac ggctgtccgg tctgcctgcg ggcgacgccg ggacggcgcc ggctccggtg 1500
gtcccctcga acgacacggc gcgggcgctg cccgtcgaga cactgccgga gctgctggca 1560
cggtacgccg cacggacccc cgacgccgta gccgtcacgg atcctcggac ctcactcacc 1620
tatgcggagc tggaccggcg cgcgaaccgt ctggcgcagc tgctccgggc ccgcggcacc 1680
gccaccggcg acctggtggg gatctgtgcc gaccgcggcg tcgatctggt cgtcggcatc 1740
gtggggatcc tcaaggcagg tgccgcgtac gtaccgctcg accccgaaca cccggcggag 1800
cggacggcgt tcgtcctgga ggacgcgcgg ctgaccacgg tggtgacgga cagcgcctat 1860
cgcccccgct tccccggcgt cccgcacgtg gtgacgcccg acgacccgca gctggcccgg 1920
cagcccgaca cggcaccgcg catcgtgctc gaccgggaca gcctcgccta cgcgatctac 1980
acctcggggt cgaccgggaa acccaaggcc gtgctcatgc cgggcgtcag cgccgtcaac 2040
ctgctgctgt ggcaggagcg gacgatgggc cgcgaaccgg ccagccggac cgtgcagttc 2100
gtgaccagca ccttcgacta ctcggtgcag gagatcttct ccgcgctgct cggcgggaca 2160
ctcgtcatcc cgccggacga ggtccggctc gacccgccgg ggctcgcacg gtggatggac 2220
gagcaggcga tcacccgcat ctacgcgccg acagcggtcc tgcgcgccct cgtcggtcac 2280
gtcgacccgc acagcgatca gctctccgcc ctgcggcacc tctgccaggg cggcgaggca 2340
ctggtcctcg acactcggct gcgcgagctc tgccgccacc ggccccggtt gcgcgtccac 2400
aaccactacg gtccggccga gagccagctc atcaccgcgt acacgctgcc ctccgacccc 2460
ggcacctggc cggccgccgc accgatcggc ccacccatcg acaacacccg gatccatctc 2520
ctcgacgacg cgctgcggcc ggttccggac gggatgccgg gccagctctg cgttgcgggc 2580
atcggcctcg cccgcggata tctggcccgc ccgggactga ccgccgagcg gtgggtcccg 2640
ggcggcgcca ccggcgagga acgcctgtac ctcacgggcg atctggcgcg ccgggcgccc 2700
tccggcgacc tcgacttcct cggccggatc gacgaccagg tcaagatccg cggcattcgc 2760
atcgagccgg gtgagatcga gaacgcgctc gccgacgacc cccgtgtcgc ggacgcggcc 2820
gtgtccgtac gggaggatcc gcggggcgag aagttcctgg cggcgtacgt cgtaccggcg 2880
ggcggaccgt acggcgacgg tttcgccgca tcgctgcgcg acggcctggc cgcccggctg 2940
cccgcctatc tcgtaccgtc ctccgtcgtc acggtggccg cgctgccccg gaccacgagc 3000
ggaaaggtgg accggcgggc actgcccgac ccggagcccg cccgggggtc ggaccggcag 3060
gccgctcccc gtaccgtcgc cgaacgggtg gtgtgccgca tcttccagga cgtgctggac 3120
gtcccccgcg tcggtgccga cgacgacttc ttcatgctgg gcgggcattc gctgctcgcc 3180
acccggctcg tttcccggat ccgtgccgag ttcggcgtcg acatcgcact gcggacgctc 3240
ttcgacggac ggacgcccgc tgccctcgcc cgcgcggtgg acacggcggg acccgccgcc 3300
gtaccgcccc cggtcctgtc cttccccggt gcggggcccg cacccgtcac cgcggcgcag 3360
gagcagatgc tgcactcgca cggttcgctg ctcgccgcgc cgtcctacac ggtcgccccg 3420
tacgggttcc ggctgtacgg gccgctcgac caccccgccc tcaacgcggc actgacccgg 3480
atcacggccc ggcacgagcc gttgcggacc gggttccacg gccggacgca gatcgtccat 3540
ccgcctgccg aggtacgtgc cgaggtggtc gagccggtgc cgggcggcgt ccctgacgcg 3600
gtccgggttg cccgcgcgga actgacccgg ccgttcgacc tggtgaacgg gccgctgctg 3660
cgcgccgtgc tcctcccgct gggtaccgag gaccacgtac tgctgctgat gctgcaccac 3720
ctcgccggtg acggctggtc gttcgacctc ctggtccggg agctgtcggg ggcatcgccc 3780
gaactgccgg tgtcctatac ggatgtcgcc cggtgggagc ggacacccga ggtcgtcgca 3840
gcgcgggaca acgaccgcag ctactggaga cggcagttgg aaggggcccg ggcgccggag 3900
ctgcccacga tccgcccccg cggtacgacg gccgcgccgg acgggcgggc cttcctctgg 3960
accctcgacg acaccacggt cgcggcggcg cgccggatct ccggcgcccg gaactcgaca 4020
ctgcaggaga ccgtgctcgg cgccttcgcc ctggtcgtgg cggaggccgc gggcaccgac 4080
gacctgctcg tcaccacacc cttcgcggac cggggccagg ccgggaccga gcatctcatc 4140
ggcttcttcg cgaaggtcct cgcactccgt gtcgacgtcg gtgacggcaa cggcggcaca 4200
gcgtcgtacc ccgaagtcct gcggcgggtc gggaccgcga tgaccggcgc ccacacccat 4260
cagtcggtgc cctactcggc gatgcgcgcg gccgatcccg cgctgccgcc ggccccactg 4320
tcgttccagc tcatcagcgc actcagtacg gagctccggc tgcccggact gcgcaccgag 4380
ccgtttcccg tcgtcgccga gagcgtcgac gacatcaacg gcgaactgtc ggtcaacctc 4440
ttcgacgacg gccgcaccgt gtcgggcgcg gtcgtccacg acgccgcgct gctcgaccgc 4500
gcggccgtca ccgacctgct cacccgggtg gagtcgacac tccgtgccgc cgcaggcgac 4560
ctcaccgtac ccgtcaccgg ccccgtggga agcgagtag 4599
<210> 40
<211> 6422
<212> PRT
<213> Streptomyces sp. GT1005
<400> 40
Val Pro Glu Gln Asp Lys Thr Val Glu Tyr Leu Arg Trp Thr Thr Ala
1 5 10 15
Glu Leu Gln Lys Ala Arg Arg Glu Leu Ala Ala His Ser Glu Pro Leu
20 25 30
Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro
35 40 45
Asp Asp Leu Trp Arg Leu Leu Asp Ser Gly Gly Asp Gly Ile Gly Ala
50 55 60
His Pro Thr Asp Arg Gly Trp Glu Thr Ser Glu Gly Gly Arg Gly Gly
65 70 75 80
Phe Leu Thr Gly Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
85 90 95
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Ile Val Leu Glu
100 105 110
Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro His Ala Leu
115 120 125
Asn Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Phe Phe Gln Gly Tyr
130 135 140
Gly Ile Gly Ala Asp Phe Asp Gly Tyr Gly Thr Thr Ser Ile His Thr
145 150 155 160
Ser Val Leu Ser Gly Arg Leu Ala Tyr Phe Tyr Gly Leu Glu Gly Pro
165 170 175
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
180 185 190
Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val
195 200 205
Gly Gly Val Thr Val Leu Ala Ser Ala Ala Gly Phe Ala Asp Phe Ser
210 215 220
Glu Gln Gly Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp
225 230 235 240
Ala Ala Asp Gly Thr Thr Phe Ala Glu Gly Ser Gly Val Leu Val Val
245 250 255
Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Val Leu Ala Val
260 265 270
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
275 280 285
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
290 295 300
Asn Ala Gly Leu Thr Thr Ala Asp Ile His Ala Val Glu Ala His Gly
305 310 315 320
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala
325 330 335
Thr Tyr Gly Gln Ser Arg Thr Thr Pro Leu Leu Leu Gly Ser Leu Lys
340 345 350
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile
355 360 365
Lys Met Ile Leu Ala Met His His Gly Thr Leu Pro Arg Thr Leu His
370 375 380
Val Asp Thr Pro Ser Thr His Val Asp Trp Thr Ala Gly Gly Ile Glu
385 390 395 400
Leu Leu Thr Glu Ala Arg Pro Trp Pro Thr Ala Ala Gly Pro His Arg
405 410 415
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
420 425 430
Leu Glu Ser Arg Pro Gln Pro Glu Ser Glu Thr Pro Pro Asp Ala Tyr
435 440 445
Ala Val Pro Leu Val Val Ser Ala Arg Thr Pro Glu Ala Leu Asp Arg
450 455 460
Gln Ile Thr Arg Val Arg Ala Phe Leu His Asp His Pro Arg Thr Asp
465 470 475 480
Arg Val Ala Val Ala Gln Thr Leu Ala Arg Arg Thr Ser Phe Glu His
485 490 495
Arg Ala Val Leu Leu Gly Asp Thr Val Val Thr Ala Asp Pro Asn Ala
500 505 510
Thr Leu Gly Pro Val Val Tyr Val Tyr Ser Gly Gln Ser Thr Leu His
515 520 525
Pro Asp Thr Gly Asn Arg Leu Ala Ala Ala Tyr Pro Val Phe Ala Asp
530 535 540
Ala Arg Arg Glu Ala Leu Gly His Leu Asp Pro Glu Pro Gly Pro Ala
545 550 555 560
Arg His Phe Ala His Gln Val Ala Leu Thr Ala Leu Leu Arg Ser Trp
565 570 575
Gly Ile Thr Pro His Ala Val Ile Gly His Ser Leu Gly Glu Ile Thr
580 585 590
Ala Ala Tyr Thr Ala Gly Ile Leu Pro Leu Arg Asp Ala Cys Thr Leu
595 600 605
Leu Thr Val Arg Ser Arg Leu Met Asp Glu Leu Pro Glu Gly Gly Ala
610 615 620
Met Val Thr Val Leu Thr Gly Glu Glu Glu Ala Arg Arg Ala Leu Arg
625 630 635 640
Pro Gly Val Glu Ile Ala Ala Val Asn Gly Pro His Ser Val Val Leu
645 650 655
Ser Gly Asp Glu Glu Ala Val Leu Asp Val Ala Gln Arg Leu Gly Ile
660 665 670
His His Arg Leu Pro Thr Arg His Ala Gly His Ser Ala Arg Met Asp
675 680 685
Pro Leu Val Ala Pro Leu Leu Glu Ala Ala Arg Gly Leu Thr Tyr His
690 695 700
Gln Pro Arg Ile Thr Val Pro Ser Gly Pro Thr Thr Ala Glu Tyr Trp
705 710 715 720
Ala Arg Gln Val Arg Asn Pro Val Arg Phe Gln Glu His Thr Glu Gln
725 730 735
Phe Pro Gly Ala Thr Phe Leu Glu Ile Gly Pro Asn Gln Asp Leu Ser
740 745 750
Pro Ile Ile Asp Gly Ile Pro Thr Gln Thr Gly Thr Pro Asp Glu Thr
755 760 765
Ala Ala Leu His Thr Ala Leu Ala Arg Leu Tyr Thr Arg Gly Val Ala
770 775 780
Val Asp Trp Thr Thr Val Leu Gly Ser Asp Arg Ala Pro Val Ala Leu
785 790 795 800
Pro Pro Tyr Pro Phe Gln His Gln Asp Tyr Trp Leu Arg Ala Thr Ala
805 810 815
Arg Ala Asp Val Thr Gly Ala Gly Gln Glu Gln Val Ala His Pro Leu
820 825 830
Leu Gly Ala Ala Val Ala Leu Pro Gly Thr Gly Gly Asn Val Leu Thr
835 840 845
Gly Arg Ile Ser Leu Ala Ser His Pro Trp Leu Gly Gly His Ala Val
850 855 860
Asn Gly Ala Val Leu Leu Pro Gly Ala Ala Phe Leu Glu Leu Ala Val
865 870 875 880
Arg Ala Gly Asp Glu Ala Gly Cys Asp Leu Leu His Glu Leu Val Val
885 890 895
Glu Thr Pro Leu Val Leu Pro Glu Ser Gly Ser Val Ala Ile Ser Val
900 905 910
Glu Val Ala Glu Pro Asp Glu Ala Gly Arg Arg Ala Val Thr Val His
915 920 925
Ala Arg Ala Asp Gly Ala Gly Pro Trp Thr His His Ala Thr Gly Phe
930 935 940
Leu Gly Lys Ala Pro Thr Gly Thr Ala Ala Thr Ala Val Ala Asp Pro
945 950 955 960
Ala Pro Trp Pro Pro Ala Gly Ala Leu Pro Val Asp Val Asp Asp Val
965 970 975
Tyr Glu Arg Phe Gly Ser Ile Gly Tyr Ala Tyr Gly Pro Pro Phe Gln
980 985 990
Gly Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr Leu His Ala Glu Val
995 1000 1005
Ala Leu Pro Asp Asp Gln Ala Ala Asp Ala Ala Arg Phe Thr Leu
1010 1015 1020
His Pro Ala Leu Phe Asp Ala Ala Phe Gln Ala Gly Ala Leu Tyr
1025 1030 1035
Ala Leu Asp Thr Pro Gly Ala Thr Ala Arg Leu Pro Phe Ser Phe
1040 1045 1050
Gln Asp Val Arg Ile His Ala Ser Gly Ala Thr Arg Ala Arg Val
1055 1060 1065
Thr Val Gly Arg Asp Gly Asp Arg Ser Thr Val Arg Met Thr Gly
1070 1075 1080
Glu Asp Gly Lys Pro Val Ala Val Val Gly Ser Val Val Ser Arg
1085 1090 1095
Pro Tyr Thr Gly Gly Ser Gly Pro Gly Asp Asp Leu Leu Arg Pro
1100 1105 1110
Val Trp Thr Glu Leu Pro Met Pro Val Pro Ser Ala Asp Asp Pro
1115 1120 1125
Arg Val Glu Ile Phe Ala Ala Asp Pro Val Asp Asp Asp Pro Thr
1130 1135 1140
Val Ala Val Arg Glu Leu Thr Gly Arg Val Leu Asp Ala Leu Arg
1145 1150 1155
Arg Arg Leu Ser Thr Thr Asp Glu Met Thr Leu Val Val Arg Thr
1160 1165 1170
Gly Thr Gly Pro Ala Ala Ala Ala Ala Ala Gly Leu Val Arg Ser
1175 1180 1185
Ala Gln Ala Glu Asn Pro Gly Arg Ile Val Leu Val Glu Ala Pro
1190 1195 1200
Pro Asp Thr Pro Ala Asp Leu Leu Ala Ala Cys Ala Ala Leu Asp
1205 1210 1215
Glu Thr Gln Leu Ala Val Arg Asp Gly Val Leu Tyr Ala Arg Arg
1220 1225 1230
Leu Val Arg Met Ser Asp Pro Val His Gly Pro Leu Pro Leu Pro
1235 1240 1245
Asp Gly Asp Trp Leu Leu Thr Arg Ser Ala Ser Gly Val Leu His
1250 1255 1260
Asp Val Thr Leu Thr Ala Asp Asp Gly Pro Arg Arg Ala Leu Glu
1265 1270 1275
Ala Gly Glu Val Arg Ile Asp Val Arg Ala Ala Gly Leu Asn Phe
1280 1285 1290
Arg Asp Val Leu Ile Ala Leu Gly Thr Tyr Glu Gly Ala Thr Ala
1295 1300 1305
Met Gly Gly Glu Ala Ala Gly Val Val Val Asp Thr Gly Pro Gly
1310 1315 1320
Val Thr Asp Leu Ser Pro Gly Asp Arg Val Phe Gly Leu Thr Arg
1325 1330 1335
Gly Gly Ile Gly Pro Thr Ala Val Thr Asp Arg Arg Trp Leu Ala
1340 1345 1350
Arg Ile Pro Asp Gly Trp Ser Phe Thr Thr Ala Ala Ser Val Pro
1355 1360 1365
Val Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Leu Ala Gly
1370 1375 1380
Leu Arg Ala Gly Glu Lys Val Leu Val His Ala Ala Thr Gly Gly
1385 1390 1395
Val Gly Met Ala Ala Thr Gln Ile Ala Arg His Leu Gly Ala Glu
1400 1405 1410
Val Tyr Ala Thr Ala Gly Thr Gly Lys His His Val Leu Arg Ala
1415 1420 1425
Ala Gly Leu Pro Gly Thr His Ile Ala Asp Ser Arg Thr Thr Ala
1430 1435 1440
Phe Arg Thr Val Phe Pro Arg Met Asp Val Val Leu Asn Ser Leu
1445 1450 1455
Thr Gly Glu Phe Ile Asp Ala Ser Leu Glu Leu Leu Asp Thr Asp
1460 1465 1470
Gly Arg Phe Val Glu Met Gly Arg Ala Glu Leu Arg Asp Pro Asp
1475 1480 1485
Thr Val Thr Pro Ala Tyr Leu Pro Phe Asp Leu Leu Asp Ala Gly
1490 1495 1500
Thr Asp Arg Ile Gly Glu Ile Leu Gly Glu Leu Leu Gly Leu Phe
1505 1510 1515
Glu Ala Gly Ala Leu Gly Pro Leu Pro Val Arg Ala Trp Asp Val
1520 1525 1530
Arg Gln Ala Arg Thr Ala Leu Asp Arg Met Ser Arg Ala Arg His
1535 1540 1545
Ile Gly Lys Asn Val Leu Thr Leu Pro Arg Pro Leu Asp Pro Asp
1550 1555 1560
Gly Ala Val Val Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile
1565 1570 1575
Leu Ala Arg His Leu Gly Gly Arg His Val Tyr Leu Leu Ser Arg
1580 1585 1590
Thr Ala Pro Pro Glu Gly Thr Pro Gly Thr Tyr Leu Pro Cys Asp
1595 1600 1605
Val Gly Asp Arg Gln Gln Leu Ala Thr Ala Leu Gly Arg Ile Asp
1610 1615 1620
Arg Pro Ile Thr Ala Val Val His Thr Ala Gly Ala Leu Asp Asp
1625 1630 1635
Ala Thr Val Pro Ser Leu Thr Arg Glu His Phe Asp Thr Val Leu
1640 1645 1650
Arg Pro Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Lys
1655 1660 1665
Asp Gln Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser Ala Ala Gly
1670 1675 1680
Val Leu Gly Asn Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala
1685 1690 1695
Phe Leu Asp Ala Leu Ala Glu Gln Arg His Ala Ala Gly Leu Pro
1700 1705 1710
Ala Leu Ser Ile Ala Trp Gly Leu Trp Glu Asp Thr Ser Ala Leu
1715 1720 1725
Thr Ala Gly Leu Gly Glu Ala Asp Arg Asp Arg Met Arg Arg Ser
1730 1735 1740
Gly Phe Arg Thr Ile Ser Ala Arg Arg Gly Met Arg Leu Tyr Glu
1745 1750 1755
Ala Ala Gly Arg Ser Gly Ser Pro Val Val Ala Ala Ala Glu Leu
1760 1765 1770
Asp Glu Ala Pro Asp Val Pro Leu Leu Arg Gly Leu Arg Arg Thr
1775 1780 1785
Thr Val Arg Arg Ala Ala Val Arg Glu Arg Ser Leu Ala Asp Arg
1790 1795 1800
Leu Ala Ala Leu Pro Asp Gly Glu Arg Ala Asp Ala Leu Leu Ala
1805 1810 1815
Leu Val Arg Asp Cys Thr Ala Thr Val Leu Gly His Leu Gly Thr
1820 1825 1830
Glu Gly Ile Pro Pro Gly Ser Thr Phe Lys Glu Leu Gly Ile Asp
1835 1840 1845
Ser Leu Thr Ala Val Gln Leu Arg Asn Gly Leu Thr Thr Ala Thr
1850 1855 1860
Gly Val Arg Leu Asn Ala Thr Ala Val Phe Asp Phe Pro Thr Pro
1865 1870 1875
Arg Ala Leu Ala Ala Lys Leu Gly Asp Glu Leu Thr Gly Val Arg
1880 1885 1890
Ala Ala Val Thr Ala Pro Ser Ala Ala Thr Asp Val Ala His Asp
1895 1900 1905
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly
1910 1915 1920
Val Thr Ser Pro Glu Glu Leu Trp Arg Leu Val Val Ser Gly Thr
1925 1930 1935
Asp Ala Ile Ser Glu Phe Pro Thr Asp Arg Asp Trp Asp Ile Asp
1940 1945 1950
Ala Leu Tyr Asp Pro Asp Pro Asp Ala Val Gly Lys Thr Phe Val
1955 1960 1965
Arg His Gly Gly Phe Leu Gly Ser Ala Thr Gly Phe Asp Ala Ala
1970 1975 1980
Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln
1985 1990 1995
Gln Arg Val Leu Leu Glu Thr Ser Trp Glu Ala Phe Glu Ser Ala
2000 2005 2010
Gly Leu Thr Pro Asp Ser Ala Arg Gly Ser Asp Thr Gly Val Phe
2015 2020 2025
Ile Gly Ala Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp Thr Asn
2030 2035 2040
Gly Phe Gly Ala Thr Gly Ser Gln Thr Ser Val Leu Ser Gly Arg
2045 2050 2055
Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ser Val Thr Val Asp
2060 2065 2070
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln
2075 2080 2085
Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
2090 2095 2100
Thr Val Met Ala Ser Pro Ser Gly Phe Val Glu Phe Ser Arg Gln
2105 2110 2115
Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Gly Ala Gly
2120 2125 2130
Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Val Leu Val Val
2135 2140 2145
Glu Arg Leu Ser Asp Ala Glu Arg His Gly Arg Thr Val Leu Ala
2150 2155 2160
Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly
2165 2170 2175
Leu Ser Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln
2180 2185 2190
Ala Leu Ala Asn Ala Arg Leu Glu Pro Ala Asp Val Asp Ala Val
2195 2200 2205
Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala
2210 2215 2220
Thr Ala Leu Leu Ala Ala Tyr Gly Gln Asp Arg Ala Glu Pro Leu
2225 2230 2235
Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala
2240 2245 2250
Ser Gly Val Ala Gly Ile Ile Lys Met Val Gln Ala Ile Arg Tyr
2255 2260 2265
Gly Glu Leu Pro Pro Thr Leu His Ala Asp Glu Pro Ser Pro His
2270 2275 2280
Val Asp Trp Ala Ser Gly Ala Val Glu Leu Leu Thr Ser Ala Arg
2285 2290 2295
Pro Trp Pro Arg Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ser
2300 2305 2310
Phe Gly Val Ser Gly Thr Asn Ala His Ile Val Leu Glu Ala Gly
2315 2320 2325
Pro Asp Pro Ala Pro Pro Pro Ala Ala Pro Val Pro Thr Pro Thr
2330 2335 2340
Pro Ala Glu Gly Leu Pro Leu Leu Val Ser Ala Arg Ser Ala Glu
2345 2350 2355
Ala Leu Asp Glu Gln Ile Ala Arg Leu Arg Ala Tyr Leu Gly Ser
2360 2365 2370
Ala Pro Asp Ile Asp Arg Ala Ala Val Ala Gln Thr Leu Ala Arg
2375 2380 2385
Arg Thr His Phe Ala His Arg Ala Val Leu Leu Gly Asp Ser Val
2390 2395 2400
Val Thr Ala Pro Pro Ala Glu Glu Ala Gly Glu Leu Val Phe Val
2405 2410 2415
Tyr Ser Gly Gln Gly Thr Gln His Pro Ser Met Gly Glu His Leu
2420 2425 2430
Ala Ala Ala Phe Pro Ala Phe Ala Gly Ala Trp Arg Asp Ala Leu
2435 2440 2445
His Arg Leu Gly Asp Pro Asp Pro His Asp Pro Thr Arg Ser Gln
2450 2455 2460
His Thr Leu Phe Ala His Gln Ala Ala Phe Thr Ser Leu Leu Glu
2465 2470 2475
Ser Trp Gly Ile Ala Pro His Ala Val Ile Gly His Ser Leu Gly
2480 2485 2490
Glu Ile Thr Ala Ala His Ala Ala Gly Ile Leu Ser Leu Asp Asp
2495 2500 2505
Ala Cys Thr Leu Val Thr Thr Arg Ala Arg Leu Met His Thr Leu
2510 2515 2520
Pro Pro Pro Gly Ala Met Val Thr Val Leu Ser Ser Glu Glu Glu
2525 2530 2535
Ala Arg Arg Ala Leu Arg Pro Gly Val Glu Ile Ala Ala Val Asn
2540 2545 2550
Gly Pro His Ser Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu
2555 2560 2565
Asp Val Ala Gln Gly Leu Gly Ile His His Arg Leu Pro Ala Pro
2570 2575 2580
His Ala Gly His Ser Ala His Met Glu Pro Val Ala Ala Glu Leu
2585 2590 2595
Leu Ala Thr Thr Arg Gln Leu Gly Tyr Gly Arg Pro Arg Val Ala
2600 2605 2610
Val Pro Asn Asp Pro Thr Thr Ala Glu Tyr Trp Ala Glu Gln Val
2615 2620 2625
Arg Lys Pro Val Leu Phe His Glu His Ala Gln Arg Tyr Pro Asp
2630 2635 2640
Ala Val Phe Val Glu Ile Gly Pro Gly Gln Asp Leu Ser Pro Leu
2645 2650 2655
Val Asp Gly Ile Ala Leu Gln Asn Gly Thr Ala Asn Glu Val Gln
2660 2665 2670
Ala Leu Tyr Thr Ala Leu Ala Arg Leu His Thr Arg Gly Ala Thr
2675 2680 2685
Leu Asp Trp Pro Leu Ile Leu Gly Gly Asp Pro Arg His Asp Pro
2690 2695 2700
Asp Val Pro Gly Tyr Ala Phe Gln Arg Arg Ala Tyr Trp Ile Ala
2705 2710 2715
Ser Ala Pro Ala Ala Thr Ala Glu Ala Gly His Pro Val Leu Gly
2720 2725 2730
Thr Gly Val Ala Leu Ala Gly Ser Pro Gly Arg Val Phe Thr Gly
2735 2740 2745
Thr Val Pro Ala Asp Gly Asp Arg Ala Val Phe Leu Ala Glu Leu
2750 2755 2760
Ala Leu Ala Ala Ala Asp Ala Ala Asp Cys Ala Thr Val Glu Arg
2765 2770 2775
Leu Asp Ile Thr Ser Leu Pro Gly Gly Ser Ala Gly Gly Arg Ala
2780 2785 2790
Thr Val Gln Leu Trp Val Gly Glu Pro Gly Ala Asp Gly Lys Leu
2795 2800 2805
Pro Phe Thr Val His Thr Arg Val Gly Gly Gly Pro Trp Thr Leu
2810 2815 2820
His Ala Glu Gly Val Leu Arg Pro Gly Gly Val Pro Val Pro Asp
2825 2830 2835
Ala Phe Asp Thr Ser Trp Pro Pro Pro Gly Ala Val Pro Ala Asp
2840 2845 2850
Gly Ser Pro Gly Ala Trp Arg Arg Gly Asp Glu Val Phe Val Glu
2855 2860 2865
Ala Glu Leu Asp Gly Ser Thr Gly Ser Thr Gly Glu Ala Gly Ser
2870 2875 2880
Ala Asp Ser Thr Gly Ser Thr Gly Phe Val Val His Pro Asp Leu
2885 2890 2895
Leu Asp Ala Val Phe Ser Ala Val Gly Gly Gly Arg Arg Pro Thr
2900 2905 2910
Ala Trp Arg Asp Leu Ala Val His Ala Ser Asp Ala Thr Val Leu
2915 2920 2925
Arg Ala Arg Leu Thr Arg Arg Thr Gly Gly Ala Val Glu Leu Ala
2930 2935 2940
Ala Phe Asp Gly Ala Gly Leu Pro Val Leu Ser Ala Ala Ser Val
2945 2950 2955
Thr Leu Gly Glu Val Ala Ser Ala Gly Asp Ala Asn Gly Leu Phe
2960 2965 2970
Gly Leu Glu Trp Val Pro Val Ala Glu Ala Val Tyr Asp Gly Thr
2975 2980 2985
Leu Pro Asp Gly Tyr Thr Leu Ile Thr Ala Ala His Pro Asp Glu
2990 2995 3000
Pro Asp Asp Leu Thr Asp Leu Thr Asp Met Pro Ala Leu Thr Gln
3005 3010 3015
Ala Arg Thr Thr Arg Thr Leu Thr Ala Leu Gln His His Leu Thr
3020 3025 3030
Thr Thr His His Thr Leu Ile Val His Thr Thr Thr Asp Pro Ala
3035 3040 3045
Gly Ala Ala Ala Thr Gly Leu Thr Lys Thr Ala Gln Asn Glu His
3050 3055 3060
Pro Asn Arg Ile His Ile Ile Glu Thr Thr His Pro His Thr Pro
3065 3070 3075
Leu Pro Leu His Gln Ile Thr Thr Leu Asn Gln Pro His Leu Arg
3080 3085 3090
Leu Thr His His Thr Leu His Thr Pro His Leu Thr Pro Leu His
3095 3100 3105
His Thr Pro Thr Pro Thr Pro Pro Leu Asn Pro His His Ala Ile
3110 3115 3120
Leu Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Leu Ala Arg
3125 3130 3135
His Leu Asn His Pro His Thr Tyr Leu Leu Ser Arg Thr Pro Pro
3140 3145 3150
Pro Pro Thr Thr Pro Gly Thr His Ile Pro Cys Asp Leu Thr Asp
3155 3160 3165
Pro His Gln Leu Thr Gln Ala Leu Thr His Ile Pro Gln Pro Leu
3170 3175 3180
Thr Ala Ile Tyr His Thr Ala Ala Thr Leu Asn Asp Ala Thr Leu
3185 3190 3195
His Asn Leu Thr Pro His His Leu Thr Thr Thr Leu Gln Thr Lys
3200 3205 3210
Ala His Thr Ala Trp His Leu His Gln Gln Thr Gln His His Pro
3215 3220 3225
Leu Thr His Phe Ile Leu Tyr Ser Ser Ala Ala Ala Thr Leu Gly
3230 3235 3240
Ser Pro Gly Gln Ala Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp
3245 3250 3255
Ala Leu Ala Thr His Arg His His Gln Gly Gln Pro Ala Thr Thr
3260 3265 3270
Ile Ala Trp Gly Met Trp Gln Thr Thr Thr Asn Leu Thr Thr Gln
3275 3280 3285
Leu Thr His Thr Asp Arg Gln Arg Ile Arg Arg Ser Gly Phe Leu
3290 3295 3300
Pro Ile Ser Asp Glu Glu Gly Met Asp Leu Tyr Asp Ala Ala Val
3305 3310 3315
Ala Ser Gly Lys Asp Phe Val Leu Ala Ala Pro Met Asp Pro Ala
3320 3325 3330
Gln Leu Ala Ser Gly Asp Val Pro Pro Ile Leu Ser Gly Leu Arg
3335 3340 3345
Arg Gly Ala Arg Arg Thr Ala Arg Pro Gly Gln Thr Phe Thr Gln
3350 3355 3360
Arg Leu Ala Asp Leu Pro Asp Ala Asp Arg Glu Thr Ala Leu Leu
3365 3370 3375
Thr Leu Val Ser Asp Ala Thr Ala Thr Val Leu Gly His Ala Asp
3380 3385 3390
Ala Ser Asp Ile Gly Pro Thr Arg Ala Phe Lys Asp Leu Gly Ile
3395 3400 3405
Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg Leu Ala Glu Ala
3410 3415 3420
Thr Gly Leu Arg Leu Ser Ser Thr Met Val Phe Asp His Pro Thr
3425 3430 3435
Pro Arg Val Leu Ala Thr Lys Leu Arg Ala Asp Leu Phe Gly Thr
3440 3445 3450
Asp Ala Pro Leu Pro Val Arg Thr Ala Gln Ala His His Asp Glu
3455 3460 3465
Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
3470 3475 3480
Ser Ala Thr Cys Cys Glu Gly Leu Trp Arg Leu Val Glu Ser Gly
3485 3490 3495
Thr Asp Ala Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Ile
3500 3505 3510
Glu Ser Leu Phe Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr
3515 3520 3525
Val Arg His Gly Gly Phe Leu Pro Glu Ala Ala Asp Phe Asp Ala
3530 3535 3540
Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Trp Ala Met Asp Pro
3545 3550 3555
Gln Gln Arg Val Ile Leu Glu Thr Ala Trp Glu Ala Phe Glu His
3560 3565 3570
Ala Gly Ile Val Pro Gly Ala Leu Arg Gly Ser Asp Thr Gly Val
3575 3580 3585
Phe Met Gly Ala Phe Ser His Gly Tyr Gly Ala Gly Val Asp Leu
3590 3595 3600
Gly Gly Phe Gly Ala Thr Ala Thr Gln Asn Ser Val Leu Ser Gly
3605 3610 3615
Arg Ile Ser Tyr Phe Phe Gly Met Glu Gly Pro Ala Val Thr Val
3620 3625 3630
Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala
3635 3640 3645
Gln Ser Leu Arg Ala Gly Asp Cys Ser Leu Ala Leu Ala Gly Gly
3650 3655 3660
Val Thr Val Met Pro Thr Pro Leu Gly Tyr Val Glu Phe Cys Arg
3665 3670 3675
Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Ala Asp
3680 3685 3690
Thr Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Val Val Ile
3695 3700 3705
Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Thr Val Leu
3710 3715 3720
Ala Leu Leu Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
3725 3730 3735
Gly Ile Ser Ala Pro Asn Gly Pro Ser Gln Gln Ala Val Ile Arg
3740 3745 3750
Arg Ala Leu Asp Arg Ala Gly Leu Ala Ala Ala Asp Val Asp Val
3755 3760 3765
Val Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu
3770 3775 3780
Ala Gln Ala Ile Ile Ala Thr Tyr Gly Gln Asp Arg Glu Thr Pro
3785 3790 3795
Leu Tyr Leu Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln Thr
3800 3805 3810
Ala Ala Gly Ile Ala Gly Val Ile Lys Met Val Met Ala Met Arg
3815 3820 3825
Tyr Gly Val Leu Pro Arg Thr Leu His Val Gly Glu Pro Ser Ser
3830 3835 3840
His Val Asp Trp Ser Ala Gly Ser Val Glu Val Leu Thr Glu Ala
3845 3850 3855
Arg Pro Trp Pro Glu Ser Asp Arg Pro Arg Arg Ala Gly Val Ser
3860 3865 3870
Ser Leu Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
3875 3880 3885
Ala Pro Glu Val Ser Val Ser Ala Ala Glu Pro Glu Ser Gly Gly
3890 3895 3900
Leu Val Pro Leu Pro Val Ser Ala Arg Ser Gly Val Gly Val Gly
3905 3910 3915
Val Leu Val Glu Arg Val Gly Gly Leu Val Gly Gly Gly Cys Asp
3920 3925 3930
Val Gly Val Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe
3935 3940 3945
Gly His Arg Ala Val Leu Leu Gly Asp Gly Val Val Arg Gly Val
3950 3955 3960
Ala Gly Glu Gly Leu Arg Thr Val Phe Val Phe Pro Gly Gln Gly
3965 3970 3975
Ser Gln Trp Val Gly Met Gly Arg Glu Leu Ala Glu Val Ser Pro
3980 3985 3990
Val Phe Ala Ala Arg Met Gly Glu Cys Ala Ala Ala Leu Ala Pro
3995 4000 4005
His Val Asp Trp Ser Trp Glu Glu Ala Leu Gly Ser Pro Glu Leu
4010 4015 4020
Leu Gly Arg Val Glu Val Val Gln Pro Leu Ser Trp Ala Val Ala
4025 4030 4035
Val Ser Leu Ala Ala Leu Trp Gly Ala His Gly Val Val Pro Asp
4040 4045 4050
Val Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
4055 4060 4065
Ala Gly Ala Leu Ser Leu Glu Asp Gly Ala Arg Val Val Ala Leu
4070 4075 4080
Arg Ser Arg Val Ile Gly Ala Arg Leu Ala Gly Arg Gly Val Met
4085 4090 4095
Ala Ser Val Ala Leu Pro Ala Ala Asp Ile Glu Thr Val Glu Gly
4100 4105 4110
Val Trp Ile Ala Ala Arg Asn Gly Pro Ser Ser Thr Val Ile Ala
4115 4120 4125
Gly Asp Ala Gln Ala Val Glu Gly Val Leu Ala Arg Tyr Glu Thr
4130 4135 4140
Ala Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His
4145 4150 4155
Thr Pro His Val Glu Ala Ile Glu Asn Glu Leu Ala Glu Ala Leu
4160 4165 4170
Thr Gly Ile Ala Ala Arg Thr Pro Ser Ile Pro Trp Trp Ser Thr
4175 4180 4185
Val Asp Ser Gly Trp Val Thr Gly Pro Val Asp Gly Gly Tyr Trp
4190 4195 4200
Tyr Arg Asn Leu Arg Gln Pro Val Ala Leu Asp Thr Ala Ile Thr
4205 4210 4215
Glu Leu Asp Gly Ser Leu Phe Val Glu Cys Ser Ala His Pro Val
4220 4225 4230
Leu Leu Pro Ala Ile Asp Gln Gln Arg Thr Val Ala Ser Leu Arg
4235 4240 4245
Thr Asp Asp Gly Gly Gly Asp Arg Phe Thr Thr Ala Leu Ala Glu
4250 4255 4260
Ala Trp Val His Gly Ala Ala Val Asp Trp Thr Thr Ile Val Pro
4265 4270 4275
Pro Thr Pro Glu Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe Asp
4280 4285 4290
His Lys Arg Tyr Trp Ile Glu Ala Ala Gly Pro Thr Asp Leu Gly
4295 4300 4305
Ala Leu Gly Leu Thr Ala Thr Ala His Ser Met Leu Ala Ala Thr
4310 4315 4320
Thr Ala Leu Pro Thr Asn Asp Gly Thr Ala Leu Thr Gly Arg Ile
4325 4330 4335
Ser Leu Arg Thr His Pro Trp Leu Ala Asp His Ala Val His Asp
4340 4345 4350
Thr Val Leu Leu Pro Gly Thr Ala Phe Leu Glu Leu Val Ile Arg
4355 4360 4365
Ala Gly Asp Glu Thr Gly Cys Asp Thr Ile Asp Glu Leu Ile Ile
4370 4375 4380
Glu Thr Pro Leu Ala Leu Pro Val Thr Gly Ala Val Asp Leu Thr
4385 4390 4395
Val Thr Val Asp Arg Pro Asp Glu Ala Gly Arg Arg Pro Val Thr
4400 4405 4410
Val His Ala Arg Pro Glu Gly Thr Gly Thr Trp Thr Arg His Ala
4415 4420 4425
Thr Gly Thr Leu Thr Thr Ser Gly Thr Thr Ala Pro Asp Ala Phe
4430 4435 4440
Pro Gln Trp Pro Pro Thr Gly Thr Thr Ala Val Asp Ile Gly Glu
4445 4450 4455
Phe Tyr Pro Arg Leu Thr Ala Leu Gly Tyr Arg Phe Gly Pro Ala
4460 4465 4470
Phe Arg Gly Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr Val Tyr
4475 4480 4485
Ala Glu Val Ala Leu Pro Glu Asp Arg Thr Ala Asp Ala Glu Arg
4490 4495 4500
Phe Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu Gln Ser Gly
4505 4510 4515
Ser Leu Leu Met Leu Glu Ser Asp Gly Ala Gln Gly Val Gln Leu
4520 4525 4530
Pro Phe Ser Trp His Gly Val Arg Phe His Ala Thr Gly Ala Thr
4535 4540 4545
Ser Leu Arg Val Ala Ile Thr Pro Gly Pro Asp Gly Leu Arg Leu
4550 4555 4560
His Ala Ala Asp Ser Gly Asn Arg Ser Val Val Ser Ile Asp Ala
4565 4570 4575
Leu Val Thr Arg Pro Pro Ala Gly Leu Ala Pro Pro Asp Pro Val
4580 4585 4590
Leu Arg Val Gly Trp Ser Thr Val Pro Val Pro Ala Asp Val Val
4595 4600 4605
Pro Cys Asp Ala Asp Val Leu Thr Leu His Ser Asn Asp Ala Asp
4610 4615 4620
Pro Leu Gln Glu Thr Arg Asp Leu Thr Thr Arg Val Leu Asp Thr
4625 4630 4635
Leu Leu Arg Ala Glu Arg Thr Leu Ile Val Gln Val Thr Gly Gly
4640 4645 4650
Leu Ala Ala Met Ala Ala Ala Gly Leu Val Arg Thr Ala Gln Asn
4655 4660 4665
Glu Arg Pro Gly Arg Phe Phe Leu Val Glu Thr Asp Pro Gly Glu
4670 4675 4680
Val Leu Asp Pro Ala Arg Cys Ala Thr Ile Ala Ala Leu Gly Glu
4685 4690 4695
Pro Arg Leu Arg Leu Arg Gly Asp Arg Tyr Glu Ala Ala Arg Leu
4700 4705 4710
Met Arg Ala Ala Pro Ala Leu Thr Leu Pro Glu Thr Gly Ser Trp
4715 4720 4725
Gln Leu Arg Arg Ser Ala Thr Gly Ser Leu Asp Asp Leu Ala Val
4730 4735 4740
Val Ala Thr Glu Glu Pro Asp Arg Pro Leu Ala Ala Gly Glu Val
4745 4750 4755
Arg Ile Ala Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Thr
4760 4765 4770
Val Ala Leu Gly Val Ile Ser Asp Glu Arg Pro Leu Gly Ser Glu
4775 4780 4785
Ala Ala Gly Val Val Leu Glu Thr Gly Pro Gly Val His Asp Leu
4790 4795 4800
Val Pro Gly Asp Arg Val Met Gly Met Leu Ala Gly Ala Phe Gly
4805 4810 4815
Pro Val Ala Ile Thr Asp Arg Arg Leu Leu Gly Arg Met Pro Asp
4820 4825 4830
Gly Trp Thr Tyr Gly Thr Gly Ala Ser Val Leu Thr Ala Phe Ala
4835 4840 4845
Thr Ala Trp Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Pro Gly
4850 4855 4860
Glu Lys Val Leu Ile His Ala Ala Ala Thr Gly Val Gly Ala Ala
4865 4870 4875
Ala Val Gln Ile Ala Arg His Leu Gly Ala Glu Val Tyr Ala Thr
4880 4885 4890
Ala Ser Thr Ala Lys Arg His Leu Leu Asp Leu Asp Gly Pro His
4895 4900 4905
Thr Ala Asp Ser Arg Ser Thr Ala Phe Ala Thr Thr Phe Pro Pro
4910 4915 4920
Val Asp Val Val Leu Asn Ala Leu Thr Gly Glu Leu Leu Asp Ala
4925 4930 4935
Ser Val Ala Leu Leu Ala Pro Gly Gly Arg Phe Ile Glu Met Gly
4940 4945 4950
Lys Thr Asp Leu Arg His Asp Ile Gln Gln Pro Phe Asp Leu Met
4955 4960 4965
Asp Ala Gly Pro Asp His Leu Gln Gln Ile Ile Thr Arg Leu Leu
4970 4975 4980
Asp Leu Phe Thr Gln Gly Thr Leu His Pro Leu Pro Val Thr Val
4985 4990 4995
His Asp Ile Arg Arg Ala Arg Glu Ala Phe Gly Trp Met Ser Ser
5000 5005 5010
Gly Arg His Thr Gly Lys Leu Val Leu Thr Val Pro Arg Pro Leu
5015 5020 5025
Asp Pro Asp Gly Ala Ile Val Ile Thr Gly Gly Ser Gly Thr Leu
5030 5035 5040
Ala Gly Ile Leu Ala Arg His Leu Asn His Pro His Thr Tyr Leu
5045 5050 5055
Leu Ser Arg Thr Pro Pro Pro Pro Thr Thr Pro Gly Thr His Ile
5060 5065 5070
Pro Cys Asp Leu Thr Asp Pro His Gln Leu Thr Gln Ala Leu His
5075 5080 5085
Gln Ile Pro Gln Pro Leu Thr Gly Ile Phe His Thr Ala Ala Thr
5090 5095 5100
Leu Asp Asp Thr Leu Ile Asp His Leu Thr Pro Thr Arg Ile His
5105 5110 5115
Thr Val Leu Gln Pro Lys Ala Asp Ala Ala Trp His Leu His His
5120 5125 5130
His Thr Arg Asn Thr Asp Leu Ala Ala Phe Val Leu Tyr Ser Ala
5135 5140 5145
Val Ala Gly Val Met Gly Ser Pro Gly Gln Gly Asn Tyr Val Ala
5150 5155 5160
Ala Asn Ala Phe Leu Asp Ala Leu Ala Glu His Arg His Ala Met
5165 5170 5175
Gly Leu Pro Ala Gln Ser Leu Ala Trp Gly Met Trp Ala Asp Val
5180 5185 5190
Ser Ala Leu Thr Ser Lys Leu Thr Ala Ala Asp Arg Glu Arg Ile
5195 5200 5205
Arg Arg Ala Gly Phe Pro Pro Leu Ser Ala Ala Asp Gly Met Arg
5210 5215 5220
Leu Leu Asp Ser Ala Ala Arg Thr Pro Glu Pro Val Val Val Ala
5225 5230 5235
Thr Thr Val Asp Thr Ala Arg Leu Asp Gly Pro Val Ala Pro Leu
5240 5245 5250
Leu Arg Ser Leu Val Ala His Arg Ser Gly Pro Val Arg Gly Val
5255 5260 5265
Ala Arg Asn Thr Gly Asp Glu Pro Leu Ala Val Arg Leu Thr Gly
5270 5275 5280
Arg Thr Val Thr Glu Gln Arg Arg Val Met Gln Asp Ile Val Leu
5285 5290 5295
Arg Gln Ala Ala Ala Val Leu Ala Tyr Gly Pro Asp Glu Gln Val
5300 5305 5310
Ala Val Asp Arg Pro Phe Arg Glu Leu Gly Phe Asp Ser Leu Thr
5315 5320 5325
Ala Val Asp Leu Arg Asn Arg Leu Ala Ala Glu Thr Gly Leu Arg
5330 5335 5340
Leu Pro Thr Thr Val Val Phe Ser His Pro Thr Ala Gln Ala Leu
5345 5350 5355
Ala Gly His Leu Leu Glu Leu Leu Gly Ala Pro Ala Thr Arg Ser
5360 5365 5370
Ala Ala Asp Ser Val Pro Ala Pro Ala Val Arg Asp Arg Asp Arg
5375 5380 5385
Asp Arg Asp Arg Asp Arg Asp Glu Pro Ile Ala Ile Val Ala Met
5390 5395 5400
Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro Glu Asp Leu Trp
5405 5410 5415
Arg Leu Val Glu Ser Gly Thr Asp Ala Ile Thr Val Pro Pro Gly
5420 5425 5430
Asp Arg Gly Trp Asp Leu Asp Ala Leu Tyr Asp Ala Asp Pro Asp
5435 5440 5445
Ala Val Gly Lys Ala Tyr Asn Leu Arg Gly Gly Phe Leu Asp Gly
5450 5455 5460
Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu
5465 5470 5475
Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ala
5480 5485 5490
Trp Glu Ala Val Glu Arg Gly Arg Ile Asp Pro Ala Ser Leu His
5495 5500 5505
Gly Arg Glu Val Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr
5510 5515 5520
Gly Leu Gly Ala Glu His Pro Glu Ser Pro Gly His Pro Gln Tyr
5525 5530 5535
Thr Glu Gly Asn Ala Val Thr Gly Ser Ser Thr Ser Leu Leu Ser
5540 5545 5550
Gly Arg Ile Ala Tyr Val Leu Gly Leu Glu Gly Pro Ala Val Thr
5555 5560 5565
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala
5570 5575 5580
Cys Gln Gly Leu Arg Leu Gly Glu Cys Glu Leu Ala Leu Ala Gly
5585 5590 5595
Gly Val Ser Val Leu Ser Ala Thr Cys Cys Ala Ala Phe Ile Glu
5600 5605 5610
Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser
5615 5620 5625
Phe Gly Ser Gly Ala Asp Gly Thr Thr Trp Ala Glu Gly Val Gly
5630 5635 5640
Val Leu Val Leu Glu Arg Leu Ser Asp Ala Glu Arg Leu Gly His
5645 5650 5655
Ala Val Leu Ala Val Val Arg Gly Ser Ala Val Thr Ser Asp Gly
5660 5665 5670
Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Leu Ser Gln Gln Arg
5675 5680 5685
Val Ile Arg Lys Ala Leu Ala Ala Ala Gly Leu Thr Ala Ala Asp
5690 5695 5700
Val Asp Val Val Glu Gly His Gly Thr Gly Thr Arg Leu Gly Asp
5705 5710 5715
Pro Val Glu Ala Asp Ala Leu Leu Ala Thr Tyr Gly Gln Asn Arg
5720 5725 5730
Arg Asp Pro Val Arg Leu Gly Ser Leu Lys Ser Asn Ile Gly His
5735 5740 5745
Ala Thr Ala Ala Ala Gly Val Ala Ser Val Ile Lys Met Val Gln
5750 5755 5760
Ala Ile Gly Ala Gly Thr Met Pro Arg Thr Leu His Ala Asp Glu
5765 5770 5775
Pro Ser Pro Ala Val Asp Trp Thr Thr Gly Arg Val Ala Leu Leu
5780 5785 5790
Thr Glu Asn Arg Pro Trp Pro Asp Asp Glu Ser Pro Arg Arg Ala
5795 5800 5805
Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Leu Val
5810 5815 5820
Leu Glu Gln His Arg Pro Ala Pro Ala Gly Pro Arg Pro Ala Arg
5825 5830 5835
Ala Glu Pro Arg Pro Val Pro Trp Val Leu Ser Ala Arg Ser Pro
5840 5845 5850
Ala Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg Asp His Leu Ala
5855 5860 5865
Ala Val Pro Ala Ala Asp Pro Leu Asp Ile Gly Tyr Ala Leu Ala
5870 5875 5880
Thr Ser Arg Ala Arg Leu Pro Tyr Arg Ala Ala Ala Val Ala Thr
5885 5890 5895
Asp Thr Asp Gly Phe Arg Thr Val Leu Asp Gly Ile Ala Asp Gly
5900 5905 5910
Val Asp Ala Pro Gly Ala Val Thr Gly Thr Ala Arg Asp Arg Arg
5915 5920 5925
Ile Ala Phe Leu Phe Asp Gly Gln Gly Thr Gln Arg Thr Gly Met
5930 5935 5940
Gly Arg Glu Leu His Arg Ser Phe Pro Val Phe Ala Ala Ala Trp
5945 5950 5955
Asp Glu Val Ser Asp Ala Phe Ala Gly Gln Leu Glu His Ser Pro
5960 5965 5970
Thr Asp Val Phe His Gly Ala His Gly Glu Leu Ala Asn Asp Thr
5975 5980 5985
Leu Tyr Ala Gln Ala Gly Leu Phe Thr Leu Glu Val Ala Leu Leu
5990 5995 6000
Arg Leu Leu Asp His Trp Gly Val Arg Pro Asp Val Val Val Gly
6005 6010 6015
His Ser Val Gly Glu Val Thr Ala Ala His Ala Ala Gly Val Leu
6020 6025 6030
Thr Leu Thr Asp Ala Thr Arg Leu Ile Val Ala Arg Gly Arg Ala
6035 6040 6045
Leu Gln Ala Leu Pro Pro Gly Ala Met Thr Ala Val Asp Gly Ser
6050 6055 6060
Leu Ala Glu Val Gly Ala Phe Thr Gly Ser Thr Asp Leu Asp Val
6065 6070 6075
Ala Ala Val Asn Gly Pro Thr Gly Val Val Leu Thr Gly Ser Pro
6080 6085 6090
Asp Asp Val Ala Ala Phe Glu Arg Glu Trp Ala Ala Ala Gly Arg
6095 6100 6105
Arg Ala Lys Arg Leu Asp Val Gly His Ala Phe His Ser Arg His
6110 6115 6120
Val Asp Gly Ala Leu Asp Asp Phe Arg Thr Val Leu Glu Ser Ile
6125 6130 6135
Pro Phe Gly Ala Ala Gln Leu Pro Val Val Ser Thr Thr Thr Gly
6140 6145 6150
Arg Glu Ala Ala Asp Asp Leu Ala Thr Pro Glu His Trp Leu Arg
6155 6160 6165
His Ala Arg Arg Pro Val Leu Phe Ala Asp Ala Val Leu Glu Leu
6170 6175 6180
Ala Asp Arg Gly Val Asn Met Phe Val Ala Val Gly Pro Ser Gly
6185 6190 6195
Ala Leu Ala Ser Ala Ala Ser Glu Asn Thr Gly Gly Asp Ala Gly
6200 6205 6210
Thr Tyr His Ser Val Leu Arg Ala Arg Ala Gly Glu Glu Thr Ala
6215 6220 6225
Ala Leu Thr Ala Ala Ala Glu Leu His Val His Gly Ala Pro Val
6230 6235 6240
Asp Leu Ala Val Val Leu Asp Gly Gly Arg Pro Val Asp Leu Pro
6245 6250 6255
Val Tyr Pro Phe Gln His Arg His Tyr Trp Leu Ala Ser Gly Pro
6260 6265 6270
Gly Arg Ser Thr Pro Thr Ala Ser Pro Asp Thr Gly Trp Gly Glu
6275 6280 6285
Glu Pro Glu Ala Gly Asp Leu Gly Ile Ala Glu Ile Val Arg Arg
6290 6295 6300
Ser Thr Ala Ala Leu Leu Gly Val Thr Asp Pro Ala Asp Val Asp
6305 6310 6315
Thr Asp Ser Thr Phe Phe Ala Leu Gly Phe Asp Ser Leu Ala Val
6320 6325 6330
Gln Arg Leu Arg Asn Arg Leu Thr Ser Ala Thr Gly Leu Asp Leu
6335 6340 6345
Pro Thr Ser Val Leu Phe Asp His Asp Thr Pro Ala Ala Leu Thr
6350 6355 6360
Ala Tyr Leu Glu Asp Arg Leu Gly Asp Gly Ala Asp Asp Asp Pro
6365 6370 6375
Pro Thr Val Leu Glu Leu Leu Thr Glu Met Glu Ser Leu Asp Ala
6380 6385 6390
Ala Asp Ile Ala Ala Thr Pro Ala Pro Glu Arg Ala Ala Ile Ala
6395 6400 6405
Asp Leu Leu Asp Thr Leu Ser Arg Val Trp Lys Asp His Arg
6410 6415 6420
<210> 41
<211> 19257
<212> DNA
<213> Streptomyces sp. GT1005
<400> 41
gtgcccgaac aggacaaaac ggtcgagtac ctgcgctgga ccaccgcgga actgcagaag 60
gcccggaggg aactcgccgc gcacagcgag cccctggcga tcgtcggtat ggcgtgccgg 120
ctgccgggcg gggtggcatc gccggacgat ctgtggcggc tgctcgactc cggcggcgac 180
ggcatcggcg cgcatcccac cgaccgcggc tgggagacgt ccgaaggcgg tcgcggcgga 240
ttcctcaccg gtgcggccgg attcgatgcc gcgttcttcg ggatcagccc gcgcgaggcc 300
ctcgcgatgg acccgcagca gcggatcgtc ctggaaacgt cgtgggaggc gctcgaacac 360
gcgggcatcg acccccatgc gctgaacggc agcgataccg gggtgttcct gggagcgttc 420
ttccaggggt acggaatcgg cgccgacttc gacgggtacg gcaccaccag catccatacg 480
agcgtcctct ccggccgcct cgcctatttc tacggactgg agggcccggc ggtcacggtc 540
gatacggcgt gctcgtcgtc gctggtcgcc ctgcaccagg ccggtcagtc gctgcgtacc 600
ggggaatgct ccctggcact ggtcggcggc gtcacggtac tggcgtccgc ggcgggcttc 660
gcggacttct ccgagcaggg cggtctggcg ccggacggcc ggtgcaaggc cttcgcggac 720
gccgcggacg gcaccacctt cgccgaaggc tccggtgtcc tggtggtgga gcggctttcc 780
gacgccgaac gccacggcca ccgcgtcctc gcggtcgtac gcggctccgc cgtcaaccag 840
gacggcgcct ccaacggact ctccgcaccc aacggaccct cccaggaacg cgtcatccgg 900
caagccctcg ccaacgcggg actcaccacc gccgacatcc acgccgtgga agcgcacggc 960
accggcaccc gcctcgggga ccccatcgaa gcgaccgcac tgctcgccac ctacggacag 1020
agccgcacca caccgctcct cctcggctcc ctgaagtcca acatcggcca cacccaggcc 1080
gccgcgggcg tcgcgggcat catcaaaatg atcctcgcca tgcaccacgg caccctgccc 1140
cgcaccctgc acgtcgacac accgtccacc cacgtcgact ggacggcggg aggcatcgaa 1200
ctcctcaccg aagcccggcc ctggcccacg gctgcggggc cccaccgcgc cggtgtctcc 1260
tccttcggcg tcagcggcac caacgcccac gtcatcctcg aaagccgccc ccagccggaa 1320
tccgagaccc cgcccgacgc ctacgccgtg cccctggtcg tctccgcccg gacccccgag 1380
gcgctcgacc ggcagatcac ccgggtacgc gcgttcctcc acgaccatcc gcgcacggac 1440
cgcgtggccg tcgcgcagac cctggcccgg cgcacctcct tcgaacaccg tgccgtactg 1500
ctcggcgaca cggtcgtcac cgcggacccg aacgccaccc tcgggccggt cgtctacgtc 1560
tactcgggac agagcaccct gcacccggac accggcaacc ggctggcggc cgcctacccg 1620
gtcttcgcgg acgcacggcg cgaggcgctc ggtcacctcg acccggagcc gggtccggcc 1680
aggcacttcg cccaccaggt tgccctcacc gcactgctgc ggtcctgggg catcactccg 1740
cacgcggtca tcggccactc cctcggtgag atcaccgccg cgtacacggc cggaatcctg 1800
ccgctgcgcg acgcgtgcac gctcctgacc gtccgcagcc gcctcatgga cgaactcccg 1860
gagggcggcg cgatggtcac cgtcctcaca ggcgaggagg aggcgcgccg ggcgctgcgc 1920
cccggagtgg agatcgccgc cgtcaacggc ccccactccg tcgtgctctc cggcgacgaa 1980
gaagccgtac tcgacgtcgc ccagcggctc ggcatccacc accggctgcc gacgcgccac 2040
gccgggcact ccgcccggat ggatccgctc gtcgcgccgc tgctcgaagc cgcccggggg 2100
ctgacgtacc accagccccg catcaccgtc ccctcgggcc ccaccacggc cgagtactgg 2160
gcgcgccaag tccgcaaccc ggtgcgcttc caggagcaca ccgaacagtt ccccggcgcc 2220
acgttcctgg agatcgggcc caaccaggac ctctccccga tcatcgacgg cattcccacc 2280
cagacgggga cgcccgacga gaccgcggcg ctccacaccg ccctcgcgcg tctgtacacc 2340
cgtggggtcg cggtcgactg gacgaccgta ctcggcagtg accgcgcacc cgtcgcgctg 2400
cccccgtacc cgttccagca ccaggactac tggctgcggg ccaccgcccg ggcggatgtg 2460
accggcgcgg ggcaggaaca ggtcgcgcac ccgctgctcg gtgccgcggt cgcgctcccc 2520
ggcaccggcg gaaacgtcct gaccggacgg atctccctgg cctcccatcc gtggctcggc 2580
gggcacgccg tcaacggggc cgtgctcctg cccggtgcgg cgttcctcga actcgcggtg 2640
cgcgccggtg acgaggccgg atgcgatctt ctccacgaac tggtggtcga gaccccgctc 2700
gtgctgccgg agagcggctc cgtcgcgatc tccgtcgagg tggccgagcc cgacgaggcg 2760
gggcgccgcg cggtgaccgt ccacgcgcgc gccgacggtg ccggcccgtg gacccaccac 2820
gccaccggct tcctcggcaa ggcacccacc gggaccgcag cgaccgcggt ggcggacccg 2880
gcgccctggc cgcccgccgg ggccctgccg gtcgacgtgg acgacgtcta cgagcggttc 2940
gggagcatcg gatacgcata cgggccgccg ttccaggggc tgcgggcggc gtggcgtgac 3000
ggcgacaccc tccacgccga ggtcgcgctc cccgacgatc aggcggcgga cgccgcccgg 3060
ttcaccctgc accccgcgct gttcgacgcc gcgttccagg ccggtgcgct gtacgcgctc 3120
gacacgcccg gggcgacggc ccggctgccg ttctcgttcc aggacgtccg catccatgcg 3180
tccggggcca cacgggcacg cgtcaccgtc ggccgcgacg gtgatcgcag caccgtacgc 3240
atgaccggcg aggacggaaa gcccgtggcc gtcgtcgggt cggtggtgtc gcgcccgtac 3300
accggtggat ccggccccgg cgacgacctg ctgcgcccgg tctggaccga gctgccgatg 3360
cccgtacctt ccgcggacga tccgcgcgtg gagattttcg ctgcggaccc cgtcgacgac 3420
gacccgaccg tggcggtgag ggagctgacg ggccgcgtcc tcgacgccct gcggcgccgg 3480
ctgtccacca ccgacgagat gaccctcgtc gtccggaccg gcaccggccc ggcggcggcc 3540
gccgcggcgg gcctggtccg ctcggcacag gcggagaacc ccgggcggat cgtcctcgtc 3600
gaggcgcccc cggacactcc tgcggacctc ctcgccgcgt gcgccgcact ggacgaaacg 3660
cagctggccg tccgggacgg tgtgctctac gcacggcggc tggtacggat gtccgacccg 3720
gtgcacggcc cgctgcccct gccggacggc gactggctgc tcacccgctc cgcctccgga 3780
gtcctgcacg acgtcacgct gaccgccgac gacgggcccc gccgcgcact cgaagccggc 3840
gaggtccgca tcgacgtccg ggccgcgggc ctgaacttcc gggacgtcct gatcgcgctg 3900
gggacgtacg agggggcgac cgccatgggc ggtgaggccg cgggcgtcgt cgtggacacc 3960
gggcccggcg tgaccgacct ctcccccggt gaccgggtct tcggcctgac ccggggcggt 4020
atcggcccga ccgccgtcac ggaccggcgc tggctggcgc ggatacccga cgggtggagc 4080
ttcaccacgg cggcatccgt cccggtggtg ttcgcgaccg cctggtacgg cctggtcgac 4140
ctcgcggggc tgcgcgcggg cgagaaggtc ctcgtgcacg cggccaccgg cggtgtcggc 4200
atggccgcca cgcagatcgc ccggcacctc ggcgccgagg tctatgccac cgccggtacc 4260
gggaagcatc atgtgctgcg cgccgccggg ctgcccggca cgcatatcgc cgactcacgg 4320
acgacggcgt tccggaccgt cttcccgcgg atggacgtcg tcctcaactc cctgaccggc 4380
gagttcatcg acgcttcact cgaactcctg gacacggacg gccggttcgt cgagatgggc 4440
cgcgccgagc tgcgcgatcc ggacaccgtc acgcccgcct atctgccgtt cgacctcctc 4500
gacgcgggca ccgaccgcat cggcgagatc ctgggcgaac tcctcgggct gttcgaggcg 4560
ggcgcgctcg gtccgctgcc ggtccgcgcc tgggacgtcc ggcaggctcg gaccgcgctc 4620
gaccggatga gccgagcccg ccacatcggc aagaacgtcc tcacgctccc ccggccgctc 4680
gacccggacg gcgcggtcgt catcaccggc ggttcgggca ccctcgccgg catcctggcc 4740
cgtcacctcg gcgggcggca cgtctatctg ctgtcccgga cggcgccgcc ggagggaaca 4800
cccggcacct atctgccgtg cgacgtcggc gaccggcagc aactggcgac ggcactgggg 4860
cggatcgacc ggccgatcac cgccgtggtg cacacggcgg gcgcgctgga cgacgccacc 4920
gtcccttcgc tcacgcgcga gcacttcgac accgtcctgc gcccgaaggc cgacggcgcc 4980
tggcatctgc acgaactcac caaggaccag gacctcgcgg cgttcgtgct ctactcgtcg 5040
gccgccgggg tgctcggcaa cgcgggccag ggcaactacg ccgcggccaa cgccttcctc 5100
gacgcgctcg ccgaacagcg ccacgcggcg ggcctgcccg cgctgtccat cgcctgggga 5160
ctctgggagg acacgagcgc gctcaccgcc gggctcggtg aggcggaccg ggaccggatg 5220
cggcggagcg gattccgtac gatcagcgcg cgacggggca tgcgtctgta cgaggcggcg 5280
gggcgcagcg ggagtcccgt ggtggcagct gccgaactcg acgaggcgcc ggacgtaccg 5340
ctgctgcggg ggctccggcg tacgaccgtg cggcgtgccg ccgtccggga gcgctccctc 5400
gccgaccggc tcgccgcgct gccggacggc gagcgcgcgg atgcactcct cgcgctcgtc 5460
cgggactgta cggccaccgt gctcggccat ctgggtaccg aagggattcc gccggggtcg 5520
acgttcaagg agctcggcat cgactcgctg accgcggtcc agctccgcaa cgggctcacc 5580
acggcgaccg gtgtacgcct caacgccacg gcggtcttcg acttcccgac gccccgggcg 5640
ctcgcggcga agctcggtga cgagctgacc ggggtccgcg cggccgtcac ggcccccagc 5700
gcggccacgg acgtggcgca cgacgaacca ctggcgatcg tgggcatggc ctgccgtctg 5760
ccgggcgggg tcacctcgcc ggaggagctg tggcggctcg tcgtgtccgg caccgacgcc 5820
atcagcgagt tccccacgga ccgcgactgg gacatcgacg ccctctacga ccccgacccc 5880
gacgccgtcg gcaagacgtt cgtccggcac ggcggcttcc tcggcagtgc gaccggcttc 5940
gacgcggcgt tcttcggcat cagtccgcgc gaggccctgg ccatggatcc gcagcagcgg 6000
gtcctcctgg agacgtcctg ggaggcgttc gaaagtgccg gactgacccc ggactcggcc 6060
cggggcagcg acaccggcgt cttcatcggc gcgttctcct acggctacgg cacgggtgcg 6120
gataccaacg gcttcggcgc gacgggctcg cagacgagcg tgctctccgg acggctctcc 6180
tacttctacg gtctggaggg gccgtcggtc accgtcgaca ccgcctgctc gtcgtcgctg 6240
gtcgcgctcc accaggccgg tcagtccctg cgtaccgggg agtgttccct ggcgctggtc 6300
ggcggcgtca cggtgatggc gtcccccagc ggcttcgtcg agttctcccg gcagcgcggt 6360
ctcgcaccgg acgggcgggc gaaggcgttc ggcgcgggcg cggacggtac gagcttcgcc 6420
gagggcgccg gtgtcctggt cgtggagcgg ctgtccgacg cggaacgcca cgggcgtacc 6480
gtcctcgcgg tcgtccgcgg ctccgcggtc aactccgacg gcgcctcgaa cggtctgtcg 6540
gcgcccaacg ggccgtcgca ggagcgggtc atccggcagg ccctcgcgaa cgcgcggctc 6600
gaaccggcgg acgtcgacgc ggtcgaggcc catggcaccg gcacccgcct cggcgacccc 6660
atcgaggcga ccgcgctgct cgcggcgtac gggcaggacc gggcggagcc cctgctgctc 6720
ggctcgctga agtcgaacat cgggcatgcg caggccgcgt ccggtgtggc cgggatcatc 6780
aagatggtgc aggcgatccg gtacggggag ctgccgccga cgctccacgc ggacgagccg 6840
tcgccgcatg tcgactgggc gtccggcgcc gtcgagctgc tgacgtcggc ccggccgtgg 6900
ccgcggaccg gccgtccgcg ccgtgccgcc gtctcgtcgt tcggggtgag cggcacgaac 6960
gcccatatcg tcctggaggc cgggccggac cctgcaccgc ccccggcggc accggtaccg 7020
acaccgacac cggccgaggg gctgccgctg ctggtgtcgg cgcggtccgc ggaggcactc 7080
gacgagcaga tcgcgcgcct gcgcgcctat ctcggctccg ctccggacat cgaccgggcg 7140
gcggtggcgc agacactggc ccggcggacg cacttcgccc accgtgccgt gctgctcggt 7200
gactccgtcg tcaccgctcc cccggcggag gaagccgggg agctggtctt cgtctactcc 7260
ggccagggca cccagcatcc gtcgatgggc gagcacctcg ccgccgcctt ccccgccttc 7320
gccggggcgt ggcgggacgc gctccaccgg ctcggtgacc ccgatcccca cgaccccacg 7380
cgaagccagc acacgctctt cgcccaccag gcggcgttca cctccctgct ggagtcctgg 7440
ggcatcgccc cgcacgcggt gatcggccac tccctcgggg agatcaccgc cgcccacgcg 7500
gccgggatcc tgtcgctcga cgacgcgtgc accctggtca cgacccgtgc ccgcctgatg 7560
cacacgctgc cgccgcccgg tgccatggtc accgtgctga gcagtgagga ggaggcgcgg 7620
cgggcactcc ggccgggcgt ggagatcgcc gcggtcaacg gcccccactc cgtcgtgctc 7680
tccggcgacg aggacgcggt gctcgatgtc gcgcaggggc tcggcatcca ccaccggctg 7740
cccgcgccgc acgcgggaca ctccgcgcat atggagccgg tggccgccga gctgctcgcg 7800
accacccggc agctcggcta cggcaggccc cgcgtcgccg tccccaacga cccgaccacc 7860
gccgagtact gggccgagca ggtccgtaag ccggtgctgt tccatgagca cgcgcagcgg 7920
tatcccgatg cggtgttcgt cgagatcggc cccgggcagg atctctcacc gttggtcgac 7980
ggcatcgccc tgcagaacgg cacggcgaac gaggtgcagg cgctgtacac agcgctcgcc 8040
cgcctccaca cgcggggcgc gacgctcgac tggcccctga tcctgggcgg tgacccgcgt 8100
cacgacccgg acgttccggg gtacgccttc cagcgacgcg cctactggat cgcatcggcg 8160
cccgcggcca cggccgaagc gggccacccc gtcctcggca ccggagtcgc cctcgccggg 8220
tcgcccggcc gggtgttcac gggcaccgtc ccggcggacg gggaccgcgc ggtgttcctc 8280
gccgaactgg ccctggccgc cgcggacgcg gccgactgcg ccacggtcga acgtctcgac 8340
atcaccagcc tgcccggcgg atccgccggg ggccgggcca ccgtgcagct ctgggtcggt 8400
gagcccgggg cggacggcaa gctcccgttc acggtgcaca cccgtgtcgg cggcggcccg 8460
tggacgctgc acgccgaggg tgtgctccgc cccggcggcg tacccgtgcc cgatgccttc 8520
gacacctcgt ggcccccgcc gggcgcggtg cccgccgacg ggtcgcccgg ggcgtggcgg 8580
cgcggggacg aggtgttcgt cgaggcggaa ctagacggat cgaccggatc gaccggagag 8640
gccggatcag ccgactcgac cggctcgacc ggcttcgtgg tccaccccga tctgctcgac 8700
gcggtcttct cggccgtcgg cggcggccgc cggccgaccg cctggcgcga tctcgcggtg 8760
cacgcgtcgg acgccaccgt gctgcgtgcc cgtctcaccc gccgtacggg cggtgccgtg 8820
gaactcgccg ccttcgacgg tgccggtctg ccggtactca gcgcggcctc ggtgaccttg 8880
ggcgaggtcg catcggcggg cgatgcgaac ggcctgttcg ggttggagtg ggtgccggtg 8940
gcggaagccg tctacgacgg gaccctgccc gacggctaca ccctcatcac cgccgcacac 9000
cccgacgagc cggacgacct caccgacctc accgatatgc ccgccctcac ccaagcccgc 9060
accacccgca ccctcaccgc cctccaacac cacctcacca ccacccacca caccctcatc 9120
gtccacacca ccaccgaccc cgcaggcgcc gcagccaccg gactcaccaa aaccgcccag 9180
aacgaacacc caaaccgcat ccacatcatc gaaaccaccc acccccacac acccctcccc 9240
ctccaccaga tcaccaccct caaccaaccc cacctccgac tcacccacca caccctccac 9300
acaccccacc tcacccccct ccaccacacc cccaccccca caccacccct caacccccac 9360
cacgccatcc tcatcaccgg cggctccggc accctcgccg gaatcctcgc ccgccacctc 9420
aaccaccccc acacctacct cctctcccga acaccaccac cccccaccac ccccggcacc 9480
cacatcccct gcgacctcac cgacccccac caactcaccc aagccctcac ccacataccc 9540
caacccctca ccgccatcta ccacaccgca gccaccctca acgacgccac cctccacaac 9600
ctcacccccc accacctcac caccaccctc caaaccaaag cccacaccgc ctggcacctc 9660
caccaacaaa cccaacacca ccccctcacc cacttcatcc tctactcctc agcagccgcc 9720
accctcggca gccccggaca agccaactac gccgccgcca acgccttcct cgacgccctc 9780
gccacccacc gccaccacca aggacaaccc gccaccacca tcgcctgggg catgtggcaa 9840
accaccacca acctcaccac ccaactcacc cacaccgacc gacagcgcat ccgccgcagc 9900
ggcttcctgc ccatctcgga cgaagaaggc atggacctct acgacgcggc tgtcgcctcc 9960
ggcaaggatt tcgtgctggc ggccccgatg gacccggcgc agctggcatc cggtgacgta 10020
ccgccgatcc tgagcggtct gcgccgaggc gcgcgccgta ccgcccggcc cgggcagacg 10080
ttcacccagc ggctcgcgga cctgcccgac gccgaccgtg agacggccct gctcactctg 10140
gtgtcggacg ccaccgcgac cgtgctcggc catgccgacg cctcggacat cggaccgacc 10200
agggcgttca aggatctcgg catcgactcg ctcaccgcca tcgagctgcg gaaccggctc 10260
gcggaggcga ccgggctccg gctgagctcc acgatggtgt tcgaccatcc gacaccgcgg 10320
gtgctggcca cgaagctccg cgccgatctg ttcggcacgg acgcgccgtt gcccgtacga 10380
accgcacagg cccaccacga cgaacccctc gcgatcgtcg gcatggcctg tcgtctgccc 10440
ggcggcgtct cctcgcccga gggcctgtgg cggctcgtcg agtccggcac ggacgcgatc 10500
accgagttcc ccgccgaccg cggctgggac atcgagtcac tgttcgaccc ggacccggac 10560
gcgcccggca agacgtacgt ccggcacggc ggcttcctcc ccgaggccgc ggacttcgat 10620
gccgcgttct tcgggatcag cccgcgcgag gcatgggcca tggacccgca gcagcgtgtc 10680
atcctcgaaa cggcctggga ggcgttcgag cacgcgggca tcgtcccggg cgcactgcgg 10740
ggcagcgaca ccggcgtgtt catgggcgcg ttctcccacg ggtacggcgc aggcgtcgac 10800
ctgggcggct tcggcgccac ggccacccag aacagcgtgc tctccggtcg tatctcctac 10860
ttcttcggca tggaaggacc ggccgtcacc gtcgacacgg cgtgctcgtc gtcactggtc 10920
gcgctccacc aggccgcaca gtcgctccgg gccggggact gttccctggc gctggccggc 10980
ggggtcacgg tcatgcccac accgctggga tacgtcgaat tctgccgcca gcgcggactc 11040
gcacccgacg gccgggccaa ggcgttcgcg gacaccgccg acggcaccag cttctcggaa 11100
ggcgccggtg tcgtcatcgt ggagcggctc tccgacgccc ggcgcaacgg acacaccgtc 11160
ctcgcgctcc tgcgctcctc agccgtcaac caggacggtg cctccaacgg catctccgcg 11220
cccaacggcc cgtcccagca ggccgtcatc cgcagggcac tcgaccgggc ggggctcgcc 11280
gccgccgacg tcgacgtggt cgaggcgcac ggcacgggta cgcccctggg cgaccccatc 11340
gaggcacagg ccatcatcgc gacgtacggg caggaccgcg agacacctct ctacctcggt 11400
tcggtcaagt cgaacatcgg ccacacccag accgcggcgg gcatcgcggg tgtcatcaag 11460
atggtgatgg cgatgcggta cggggtgctg ccgaggacgt tgcacgtcgg tgagccgtcg 11520
tcgcatgtgg actggtcggc ggggtcggtg gaggtgctga cggaggccag gccgtggccc 11580
gagtcggacc gtccgcgccg ggcaggcgtg tcgtcactcg gcatcagcgg gacgaatgcg 11640
catgtgattt tggagagtgc gccggaggtt tcggtctctg ccgctgagcc cgagtccggt 11700
ggtttggtgc cgttgccggt gtcggctcgt tcgggtgtgg gtgtgggtgt gttggtagag 11760
cgggtgggtg ggttggtggg gggtgggtgt gatgtgggtg tggtggcgga tgggttggtg 11820
cgggggcgtg cggtgttcgg tcatcgggcg gtgttgctgg gggatggtgt ggtgaggggt 11880
gtggcgggtg aggggttgcg gacggtgttc gtgttcccgg ggcaggggtc gcagtgggtg 11940
ggaatgggcc gcgaactcgc cgaagtgtca cctgtctttg cggcgcggat gggtgagtgt 12000
gcggcggcgc tggcacctca tgtggactgg tcgtgggagg aggctctggg gtcgccggag 12060
ttgctggggc gggtggaggt ggtgcagccg ttgtcgtggg cggtggcggt gagtctggct 12120
gcgctgtggg gggcgcatgg tgtggtgccg gatgtggtgg tgggtcattc gcagggggag 12180
attgctgcgg cgtgtgtggc gggtgcgctg agcctggagg acggggcgcg ggtggtggct 12240
ttgcggagcc gggtgatcgg tgcccggctg gcggggcggg gggtgatggc atcggtcgca 12300
ctccccgccg ccgacatcga gacggtggag ggggtgtgga tcgcggcccg taacggaccg 12360
tcgtcgaccg tgatcgcggg agatgcgcag gccgtggagg gggttctggc ccggtacgaa 12420
actgcggggg tacgggttcg gcggatcgcg gtcgactacg cctcccacac cccccacgtc 12480
gaggccatcg agaacgaact ggccgaagca ttaaccggta ttgcggcccg gacccccagc 12540
atcccctggt ggtccaccgt cgacagcggc tgggtcaccg gaccggtcga cggcggctac 12600
tggtaccgca acctccgtca accagtagcc ctggacaccg ccatcacaga actcgacggc 12660
tccctgttcg tcgagtgcag tgcgcatccc gtgctgctgc ccgccatcga ccagcaacgt 12720
accgtcgcct cactccgcac cgacgacggc ggcggagacc ggttcaccac cgccctggcc 12780
gaagcctggg tccacggcgc agccgtcgac tggaccacca tcgtcccgcc caccccggaa 12840
cgactcctcg acctccccac ctaccccttc gaccacaagc gctactggat agaagcggcc 12900
ggccccaccg atctcggcgc cctcggactc accgccaccg cgcactccat gctggccgcg 12960
accaccgcgc tgccgacgaa cgacggcacc gcgctcaccg gccggatctc cctgcgcacc 13020
catccctggc tggccgacca cgccgtccac gacacggtac ttctcccggg taccgcgttc 13080
ctggagctgg tgatccgcgc cggtgacgag accggctgcg acaccatcga cgagctgatc 13140
atcgaaacac cgctcgccct gcccgtcacc ggagccgtcg acctcaccgt caccgtcgac 13200
cggcccgacg aggccggacg ccgccccgtg accgtccacg cacgccccga aggaaccggc 13260
acctggaccc gccacgccac cggaaccctc accaccagcg gcaccaccgc cccggacgcg 13320
ttcccgcaat ggccgccgac cggtaccacc gccgtcgaca tcggggagtt ctatccgcgg 13380
ctcaccgcgc tgggctaccg gttcggcccc gctttccgcg ggctgcgggc ggcctggcgc 13440
gacggcgaca ccgtgtacgc cgaggtggcg ctccccgagg accgtaccgc cgacgcggaa 13500
cgcttcggtg tccatccggc cctgctcgac gccgccctgc agagcggcag cctcctgatg 13560
ctcgaatccg acggcgcgca gggtgtgcaa ctcccgttct cctggcacgg cgtccgcttc 13620
catgcgaccg gggcgacctc gctgcgggtc gcgatcacac ccggccccga cggcctccgg 13680
ctgcacgccg cggacagcgg caaccgatcc gtcgtgtcca tcgacgcgct ggtcacccgg 13740
cccccggcgg gcctcgcacc ccccgatccg gtgctccgcg tcggctggag caccgtgccc 13800
gtaccggccg acgtcgtccc gtgcgacgcg gatgtgctga cgctgcacag caacgacgcc 13860
gacccgctcc aggagacccg ggacctcacc actcgtgtgc tcgacaccct cctccgggcc 13920
gagcgcaccc tgatcgtcca agtcaccggc ggcctcgccg cgatggcggc ggcgggcctc 13980
gtacgcaccg cgcagaacga gcggcccggc cgcttcttcc tcgtcgaaac ggatcccggg 14040
gaggtcctgg accctgcacg gtgcgccacg atcgcggcgc tcggcgagcc gcggctgcgc 14100
ctgcgcggcg accgctacga ggcagcccgg ctcatgcggg ccgcaccggc cctgaccctt 14160
cccgagaccg gatcgtggca gctgcgccgg tccgccaccg ggtcgctcga cgacctcgcc 14220
gtcgttgcca ccgaagaacc ggaccggccg ctcgcggccg gagaggtgcg gatcgcggta 14280
cgggccgcgg gcctgaactt ccgtgacgtc acggtggcgc tgggcgtgat ctccgatgaa 14340
cggccgctcg gcagtgaagc cgccggggtc gtcctggaga ccggccccgg ggtgcacgac 14400
ctggtacccg gcgaccgggt catggggatg ctcgcgggcg ccttcgggcc ggtcgcgatc 14460
accgaccggc ggctgctggg ccggatgccc gacggctgga cgtacgggac cggcgcatcc 14520
gtcctgaccg ccttcgcgac ggcgtggtac ggcctggtgg atctggcggg gctgcggccc 14580
ggtgagaagg tcctgatcca cgcggcggcc accggtgtgg gcgcggcagc cgtccagatc 14640
gcccggcatc tgggcgccga ggtctacgcc accgcctcca cggcgaaacg gcacctcctg 14700
gacctcgacg gcccgcacac cgccgactcc cgcagcaccg cgttcgccac caccttcccc 14760
cccgtcgacg tcgtactcaa cgcgctcacc ggcgaactcc tcgacgcctc cgtcgccctc 14820
ctcgcacccg gcggccgctt catcgagatg ggcaaaaccg acctccgcca cgacatccag 14880
cagcccttcg acctcatgga cgccggaccc gaccacctcc agcagatcat cacccgactc 14940
ctcgacctct tcacccaagg caccctccac cccctccccg tgaccgttca cgacatccgg 15000
cgggcgcggg aggcgttcgg ctggatgagc agcggacggc atacgggcaa gctggtgctc 15060
acggtgccgc ggccgctcga ccccgacggc gcgatcgtca tcaccggcgg ctccggcacc 15120
ctcgccggaa tcctcgcccg ccacctcaac cacccccaca cctacctcct ctcccgaaca 15180
ccaccacccc ccaccacccc cggcacccac atcccctgcg acctcaccga cccccaccaa 15240
ctcacccaag ccctccacca gataccccaa cccctcaccg gcatcttcca caccgcggcc 15300
accctcgacg acaccctcat cgaccacctc acacccaccc gcatccacac cgtcctccag 15360
cccaaagccg acgccgcctg gcacctccac caccacaccc gcaacaccga cctcgccgca 15420
ttcgtcctct actccgcggt cgccggggtc atggggagcc ctggccaggg caactacgtc 15480
gcggcgaacg cgttcctgga cgcgctcgcg gagcaccggc acgccatggg tctgcccgcg 15540
cagtctctcg cctggggtat gtgggcggac gtcagcgcgc tgacgtcgaa gctcaccgcc 15600
gcggaccgtg aacgcatccg gcgcgccggg ttcccgccgc tcagcgctgc ggacggcatg 15660
cggctgctgg actcggcggc gcgtaccccg gagccggtgg tcgtcgccac gacggtcgac 15720
accgcacggc tcgacgggcc ggtcgcgccg ctgctccgca gcctggtggc ccatcggtcc 15780
gggccggtgc gcggggtcgc ccggaacacc ggggacgagc cgctggcggt acgtctcacc 15840
gggcgcaccg tcaccgaaca gcggcgcgtg atgcaggaca tcgtgctccg ccaggcggcc 15900
gcggtgctgg cctacggccc ggacgagcag gtcgcggtgg accggccgtt ccgtgaactc 15960
ggtttcgatt cgctgaccgc ggtcgacctg cgcaaccggc tcgcggccga gacggggctg 16020
cggctgccga ccacggtggt gttcagccat ccgacggcgc aggcgctcgc cgggcatctg 16080
ctggaactgc tcggcgctcc cgccacccgg tccgcggcgg actccgtgcc cgccccggcc 16140
gtacgggacc gggaccggga ccgggaccgg gaccgggacg agccgatcgc gatcgtggcg 16200
atggcctgcc gtctgcccgg tggcgtggca tcacccgagg atctgtggcg gctcgtcgag 16260
tccggcaccg atgcgatcac cgtgccgccc ggcgaccgcg gatgggatct cgacgcgctg 16320
tacgacgcgg accccgacgc ggtgggcaag gcgtacaacc tgcggggcgg cttcctggac 16380
ggggcggcgg agttcgacgc ggcgttcttc ggcatcagcc cacgggaggc gctgggcatg 16440
gacccgcagc agcgcctgct gctggagacc gcgtgggagg ccgtcgagcg cggccggatc 16500
gaccccgcgt cgctgcacgg ccgggaggtc ggtgtctacg tcggcgcggc cgcgcagggc 16560
tacggcctcg gtgccgagca ccccgagagc cccgggcacc cccagtacac cgagggcaat 16620
gcggtcaccg gcagctccac gagtctgctg tccgggcgga tcgcctacgt cctcgggctg 16680
gagggaccgg ccgtcaccgt cgacacggcg tgctcgtcgt cgctggtcgc cctgcatctg 16740
gcctgtcagg gactgcgcct gggcgaatgc gagctggcac tcgcgggcgg cgtctccgta 16800
ctcagctcgc cggccgcttt catcgagttc tcccgccagc gcggtctggc ggcggacggg 16860
cgctgcaaat cgttcggctc gggtgcggac ggtacgacgt gggccgaggg agtgggcgta 16920
ctggtcctcg aacggctgtc ggacgccgag cggctcgggc acgccgtgct cgccgtcgtc 16980
cgcggcagcg ccgtcacgtc cgacggcgcc tccaacgggc tcaccgctcc gaacggcctc 17040
tcccagcagc gggtcatccg caaggcgctg gccgcggccg gtctgaccgc cgccgatgtg 17100
gacgtcgtcg agggacacgg gaccggcacc cggctgggcg atccggtcga ggcggacgcc 17160
ctgctcgcga cgtacggaca gaaccgccgg gacccggtcc gcctcggctc gctgaagtcg 17220
aacatcgggc atgcgacggc cgcggccggg gtcgcgagcg tcatcaagat ggtgcaggcg 17280
atcggggcgg gcaccatgcc gcggacgctg cacgcggacg agccctcgcc cgccgtcgac 17340
tggaccacgg ggcgggtggc cctgctcacc gagaaccggc cctggccgga tgacgagagc 17400
ccgcggcggg cggccgtctc cgcgttcggg ctcagcggga cgaacgcgca cctcgtactc 17460
gaacagcacc gtccggcgcc cgccggaccc cggccggccc gtgcggagcc ccggccggtg 17520
ccgtgggtgc tgtccgcacg gtcgccggcc gcgctgcggg cgcaggccgc ccggctccgc 17580
gaccatctgg cggcggtccc ggcagcggac ccgctggaca tcggatacgc gctggccacc 17640
agccgcgccc ggttgccgta ccgcgccgcg gccgtcgcca ccgacaccga cgggttccgt 17700
accgtgctgg acggcatcgc ggacggcgtc gacgcgcccg gagccgtcac cgggaccgcc 17760
cgggaccgcc gcatcgcctt cctcttcgac ggccagggca cccagcgcac gggcatgggg 17820
cgcgagctgc accggagttt ccccgtcttc gccgccgcct gggacgaggt gtccgacgcc 17880
ttcgccgggc agctggaaca ctccccgacg gacgtcttcc acggtgcgca cggtgagctc 17940
gccaacgaca ccctgtacgc gcaggccggg ctgttcaccc tcgaagtggc actgctgcgg 18000
ctcctggacc actggggtgt gcgcccggac gtcgtcgtcg ggcactccgt cggggaagtc 18060
accgcggccc atgcggcggg ggtgctcacg ctcacggacg ccaccaggct gatcgtggcc 18120
cgtggccggg ccctgcaggc cctgccgccg ggggccatga ccgcggtcga cggcagcctc 18180
gcggaggtcg gtgccttcac cggctccacc gatctggacg tcgccgcggt caacggcccc 18240
accggcgtgg tcctcacggg ctcaccggac gacgtggccg cgttcgaacg ggagtgggcg 18300
gcggccgggc ggcgcgcgaa acggctggac gtcgggcacg cgttccactc gcggcatgtc 18360
gacggcgccc tcgacgactt ccgtaccgtc ctcgaatcca tcccgttcgg cgcggcacag 18420
ctgccggtgg tgtccacgac gacgggccgt gaggcggcgg acgacctcgc gaccccggaa 18480
cactggctgc gccatgcgcg ccggccggtg ctcttcgcgg acgccgtcct ggagctcgcg 18540
gaccgcggtg tgaacatgtt cgtggccgtc ggaccgtccg gggctctcgc ttcggccgcg 18600
tcggagaaca ccggcgggga cgccgggacc taccactcgg tgctgcgtgc ccgggcgggc 18660
gaggagaccg cggcgctgac cgccgccgcc gaactgcacg tacacggagc cccggtggac 18720
ctggccgtgg tgctggacgg cggacgcccg gtggacctcc ccgtctaccc gttccagcac 18780
cgccactact ggctggcatc cggcccgggc aggagtacgc cgacggcctc cccggacacc 18840
gggtggggcg aggagcccga agcgggggac ctcggcatcg ccgagatcgt ccggcggagt 18900
accgcggcgc tgctcggcgt caccgacccc gccgacgtcg acacggactc gacgttcttc 18960
gcactcggct tcgactcgct ggcggtgcag cgcctgcgca accggctcac ctccgcaacc 19020
ggtctcgacc tgccgacgtc cgtgctgttc gaccacgaca ccccggccgc cctcaccgcc 19080
tatctggagg accggctcgg cgacggcgcg gacgacgacc cgcccaccgt gctcgaactc 19140
ctgacggaga tggagtcgct cgacgccgcg gacatcgcgg cgacacccgc cccggagcgt 19200
gcggccatcg ccgatctcct cgacactctc tcccgcgtct ggaaggacca ccgatga 19257
<210> 42
<211> 388
<212> PRT
<213> Streptomyces sp. GT1005
<400> 42
Met Ser Thr Asp Thr Pro Asp Glu Thr Thr Pro Ala Gly Arg Cys Pro
1 5 10 15
Phe Ala Ile Gln Asp Gly His Arg Ala Ile Leu Ala Ser Gly Thr Val
20 25 30
Gly Ser Phe Asp Leu Phe Gly Ile Gln His Trp Leu Val Ala Gly Ala
35 40 45
Glu Asp Val Lys Leu Val Thr Asn Asp Pro Arg Phe Ser Ser Ala Ala
50 55 60
Pro Ser Glu Met Leu Pro Asp Arg Arg Pro Gly Trp Phe Ser Gly Met
65 70 75 80
Asp Leu Pro Glu His Ser Arg Tyr Arg Gln Lys Ile Ala Gly Asp Phe
85 90 95
Thr Leu Arg Ser Ala Arg Lys Gln Glu Thr Phe Val Val Glu Ala Ala
100 105 110
Asp Ala Cys Leu Asp Gly Ile Glu Ala Ala Gly Pro Gly Thr Asp Leu
115 120 125
Ile Ser Gly Tyr Ala Lys Gln Leu Pro Ser Leu Val Ile Asn Ala Leu
130 135 140
Tyr Gly Leu Thr Pro Glu Glu Gly Ala Val Leu Glu Thr Arg Met Arg
145 150 155 160
Ser Ile Thr Gly Ser Thr Asp Leu Asp Ser Val Lys Thr Leu Thr Asp
165 170 175
Asp Phe Phe Val His Ala Gly Glu Leu Val Arg Ala Lys Arg Asp Glu
180 185 190
Gln Gly Asp Asp Leu Leu His Arg Leu Ala Ser Thr Ala Asp Gly Glu
195 200 205
Ile Ser Leu Ser Asp Asp Glu Ala Thr Gly Val Phe Ala Thr Leu Leu
210 215 220
Phe Ala Gly His Asp Ser Val Gln Gln Met Val Gly Tyr Cys Leu Tyr
225 230 235 240
Ala Leu Leu Ser His Pro Glu Gln Gln Ala Ala Leu Arg Ala Gln Pro
245 250 255
Asp Leu Ile Asp His Ala Val Glu Glu Met Leu Arg Phe Leu Pro Val
260 265 270
Asn Gln Met Gly Val Pro Arg Val Cys Val Glu Asp Val Asp Leu His
275 280 285
Gly Val Arg Ile Ser Ala Gly Asp Asn Val Ile Pro Leu Tyr Ser Thr
290 295 300
Ala Asn Arg Asp Pro Arg Leu Phe Leu Asp Pro Asp Val Phe Asp Val
305 310 315 320
Arg Arg Pro Pro Glu Gly Asn Phe Ala Phe Gly His Gly Ile His Lys
325 330 335
Cys Pro Gly Gln His Ile Ala Arg Leu Leu Ile Lys Val Ala Cys Leu
340 345 350
Arg Leu Phe Glu Arg Phe Pro Asp Val Arg Leu Ala Gly Asp Val Pro
355 360 365
Met Asn Glu Gly Leu Gly Leu Phe Ser Pro Ala Glu Leu Arg Ile Thr
370 375 380
Trp Gly Thr Ala
385
<210> 43
<211> 1167
<212> DNA
<213> Streptomyces sp. GT1005
<400> 43
atgagcaccg acacacccga cgagacgacg cccgccggac gctgcccgtt cgcgatccag 60
gacggccacc gggcgatcct ggcgagcggc acggtgggct cgttcgatct gttcggcatc 120
cagcactggc tggtcgccgg tgccgaggac gtcaaactgg tcaccaacga cccgcggttc 180
agttcggccg caccgtccga gatgctgccc gaccggcgcc ccggctggtt ctccggcatg 240
gacctgccgg agcacagccg ctaccggcag aagatcgccg gggacttcac gctgcgttcc 300
gcgcgcaagc aggagacctt cgtcgtcgag gcggccgacg cctgtctgga cgggatcgag 360
gccgccgggc ccggcaccga tctgatttcc gggtacgcga agcagctccc ctccctcgtc 420
atcaacgcgc tgtacgggct caccccggag gagggagcgg tactggaaac acgcatgcgc 480
agcatcacgg gctcgaccga cctggacagc gtgaagacgc tgacggacga cttcttcgtc 540
catgccgggg agctggtccg cgccaaacgc gacgagcagg gcgacgacct gctccaccgc 600
ctcgcctcca ccgctgacgg cgagatctcg ctgagcgacg acgaggcgac gggagtgttc 660
gcgactctgc tgttcgccgg gcacgactcc gtacagcaga tggtcggcta ctgcctctac 720
gccctgctca gccaccccga acagcaggcg gccctccgtg cacaacccga tctgatcgac 780
cacgcggtcg aggagatgct gcgcttcctg ccggtcaacc agatgggagt accgcgcgtc 840
tgcgtcgaag acgtcgacct gcacggcgta cggatcagcg cgggcgacaa cgtgatcccg 900
ctctactcga cggcgaaccg cgacccgagg ctgttcctgg accccgatgt gttcgacgta 960
cggcgtccgc cggagggcaa cttcgcgttc ggccacggca tccacaagtg ccccgggcag 1020
cacatcgccc ggctgctcat caaggtcgcg tgcctgcggt tgttcgaacg cttcccggac 1080
gtccgcctcg ccggcgacgt accgatgaac gagggtctcg ggctgttcag cccggccgaa 1140
ctgcggatca cctggggtac ggcgtga 1167
<210> 44
<211> 260
<212> PRT
<213> Streptomyces sp. GT1005
<400> 44
Val Thr Pro Val Pro Glu Thr Leu Arg Leu Pro Asn Gly Thr Thr Val
1 5 10 15
Ser His Ile Asn Ala Gly Glu Ala Gln Phe Leu Tyr Arg Glu Ile Phe
20 25 30
Thr Glu Arg Cys Tyr Leu Arg Asn Gly Ile Glu Leu Leu Pro Gly Asp
35 40 45
Val Val Phe Asp Val Gly Ala Asn Ile Gly Met Phe Thr Leu Phe Ala
50 55 60
His Leu Glu Arg Pro Gly Val Thr Val His Ala Phe Glu Pro Ala Pro
65 70 75 80
Met Pro Phe Ala Ala Leu Arg Ala Asn Val Leu Arg His Gly Val Pro
85 90 95
Gly Arg Val Asp Gln Cys Ala Val Ser Asp Glu Ala Gly Val Ser Arg
100 105 110
Met Thr Phe Tyr Pro Asp Ala Thr Leu Met Ser Gly Phe His Thr Asp
115 120 125
Pro Ala Ser Arg Arg Glu Leu Leu Arg Thr Leu Gly Leu Asn Gly Gly
130 135 140
Tyr Ser Thr Glu Asp Val Asp Ile Met Leu Ala Gln Leu Pro Asp Thr
145 150 155 160
Ser Glu Glu Ile Glu Thr Thr Thr Val Arg Ile Ser Asp Val Ile Ala
165 170 175
Glu Arg Gly Ile Thr Ala Ile Gly Leu Leu Lys Ile Asp Val Glu Lys
180 185 190
Ser Glu Arg Arg Val Leu Ala Gly Ile Glu Asp Ala Asp Trp Pro Arg
195 200 205
Ile Arg Gln Val Val Ala Glu Val His Asp Thr Glu Gly Ala Leu Gly
210 215 220
Glu Val Val Ala Leu Leu His Gly His Gly Phe Thr Val Val Thr Glu
225 230 235 240
Gln Glu Pro Leu Phe Val Gly Thr Asp Ile His Gln Val Ala Ala Arg
245 250 255
Arg Pro Ala Gly
260
<210> 45
<211> 783
<212> DNA
<213> Streptomyces sp. GT1005
<400> 45
gtgaccccgg tgccggagac actgcgactg ccgaacggga cgacggtctc gcacatcaac 60
gcgggcgagg cgcagttcct gtaccgggag atcttcaccg agcgctgcta tctgcgcaac 120
ggcatcgaac tgctcccggg tgacgtggtc ttcgacgtcg gcgccaatat cggcatgttc 180
acgctcttcg cccatctgga gcggcccgga gtgaccgtgc acgccttcga gcccgcgccg 240
atgccgttcg ccgcgctacg ggccaacgtg ctgcggcacg gcgtcccggg ccgggtggac 300
cagtgcgcgg tctccgacga ggccggggtc agcaggatga cgttctaccc cgacgccacc 360
ctgatgtcgg gcttccacac ggatcccgcg agccgcagag agctgttgcg tacgctcggc 420
ctcaacggcg gctacagcac cgaggacgtc gacatcatgc ttgcccaact gcccgacacg 480
agcgaagaga tcgagaccac gacggtccgg atctccgacg tcatcgcgga gcgcggcatc 540
acggcgatcg gtcttctgaa gatcgacgtc gagaagagcg aacggcgggt cctcgccggc 600
atcgaggacg ccgactggcc ccgtatccgc caggtcgtcg ccgaggtcca cgacaccgaa 660
ggcgcgctcg gcgaagtcgt cgcgctcctg cacggccatg gcttcaccgt ggtcaccgag 720
caggaaccgc tgttcgtcgg cacggacatc caccaggtcg ccgcacggcg gccggccggc 780
tga 783
<210> 46
<211> 923
<212> PRT
<213> Streptomyces sp. GT1005
<400> 46
Val Val Pro Glu Val Arg Ala Ala Pro Tyr Glu Leu Ile Ala Arg Asp
1 5 10 15
Asp Glu Leu Ser Arg Leu His Arg Ala Leu Ser Gly Ala Glu Ser Gly
20 25 30
Arg Gly Ala Val Val Thr Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr
35 40 45
Ala Leu Leu Glu Ala Gly Ala Ala Lys Thr Gly Phe Val Thr Leu Arg
50 55 60
Ala Val Cys Ser Met Glu Glu Arg Ala Leu Pro Tyr Gly Met Leu Gly
65 70 75 80
Gln Leu Phe Asp His Pro Glu Pro Ala Ala Arg Ala Pro Gly Leu Ala
85 90 95
Arg Leu Thr Ala Ser Cys Glu Gly Pro Pro Ile Gly Thr Asp Asn Arg
100 105 110
Leu Arg Ala Glu Phe Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Arg
115 120 125
Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Gly Ala Ser
130 135 140
Leu Leu Cys Leu Leu His Leu Ala Arg Arg Ile Gly Pro Ala Arg Ile
145 150 155 160
Ser Ile Val Leu Thr Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg
165 170 175
Phe Gln Ala Glu Leu Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu
180 185 190
Arg Pro Leu Asn Glu Thr Glu Ser Ala Glu Leu Val Arg Arg His Leu
195 200 205
Gly Arg Asp Thr His Asp Asp Val Leu Ala Glu Thr Phe Arg Ala Thr
210 215 220
Gly Gly Asn Leu Leu Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu
225 230 235 240
Ala Arg Ala Thr Gly Arg Pro Glu Ala Val Ala Gly Arg Ala Tyr Arg
245 250 255
Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Thr Ala Leu His
260 265 270
Ile Ala Arg Ala Ala Ala Val Leu Gly Ala Ser Ala Glu Pro Val Leu
275 280 285
Val Gln Arg Met Thr Gly Leu Asn Thr Glu Ala Phe Glu Gln Val Cys
290 295 300
Glu Gln Leu Gln Asp Gly Arg Leu Leu Gln Asp Gly Arg Phe Pro His
305 310 315 320
Pro Glu Ala Arg Ser Ile Val Leu Asp Asp Leu Ser Ala Leu Asp Arg
325 330 335
Arg Asn Leu His Glu Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val
340 345 350
Ala Gly Asn Val Leu Ala Arg His Gln Ile Gly Thr Gly Arg Val His
355 360 365
Gly Ala Asp Ala Val Glu Leu Phe Thr Glu Ala Ala Arg Glu His Leu
370 375 380
Leu Arg Gly Glu Leu Glu Asp Ala Val Gly Tyr Leu Glu Leu Ala His
385 390 395 400
Arg Ala Cys Asp Asp Pro Val Ile Arg Ala Ala Leu Arg Ile Gly Ala
405 410 415
Ala Glu Val Glu Arg Ile Cys Asp Pro Met Arg Ala Gly Arg His Leu
420 425 430
Pro Glu Leu Leu Thr Ala Ala Arg Ala Gly Leu Leu Ser Gly Glu His
435 440 445
Ala Val Ser Leu Ala Asp Trp Leu Ala Met Gly Gly Arg Pro Gly Glu
450 455 460
Ala Ala Glu Val Leu Ala Thr Gln His Pro Ala Ala Gly Asp Asp Gln
465 470 475 480
Ser Arg Ala Leu Leu Leu Val Gly Glu Leu Ser Leu Ala Leu Val His
485 490 495
Pro Gly Arg Ser Asp Pro Ser Arg Arg Ala Asp Phe Phe Ala Ala Gly
500 505 510
Gly Leu Ala Ala Leu Arg Gly Pro Ala Arg Gln Arg Ala Val Ala Asp
515 520 525
Lys Ala Val Val Ala Ala Leu Arg Gly Arg Pro Glu Leu Ala Asp Ala
530 535 540
His Ala Glu Arg Val Leu Gln Tyr Thr Asp Ala Thr Ala Asp Arg Thr
545 550 555 560
Thr Ala Met Met Ala Leu Leu Ala Val Leu Tyr Ala Glu Asn Thr Glu
565 570 575
Ala Val Gln Phe Trp Val Asp Arg Leu Ala Gly Asp Lys Glu Thr Arg
580 585 590
Thr Pro Ala Asp Glu Ala Ile Tyr Ala Gly Phe Gly Ala Glu Thr Ala
595 600 605
Leu Arg Arg Gly Asp Leu Thr Thr Ala Val Ala Tyr Gly Glu Ala Ala
610 615 620
Leu Gly Gln Gly Leu Val Pro Thr Trp Gly Met Ala Ala Thr Leu Pro
625 630 635 640
Leu Ser Ser Thr Val Val Ala Ala Ile Arg Leu Gly Asp Ile Glu Arg
645 650 655
Ala Asp Arg Trp Leu Ser Glu Pro Leu Pro Gln Glu Thr Ser Glu Ser
660 665 670
Leu Phe Gly Leu His Leu Leu Trp Ala Arg Gly Arg Tyr His Leu Ala
675 680 685
Thr Gly Arg His Arg Ala Ala Tyr Ala Leu Phe Arg Glu Cys Gly Asp
690 695 700
Arg Met Arg Gln Trp Ala Val Asp Val Pro Gly Leu Val Leu Trp Arg
705 710 715 720
Val Asp Ala Ala Glu Ala Leu Leu Met Leu Gly Thr Asp Arg Ala Glu
725 730 735
Gly Leu Arg Leu Ile Ser Asp Gln Met Ser Arg Pro Met Arg Ser Arg
740 745 750
Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Leu Pro
755 760 765
Lys Arg Ile Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys
770 775 780
Asn Asp Gln Tyr Glu Leu Ala His Val Leu Ser Asp Leu Gly Glu Ala
785 790 795 800
Leu Asn Leu Val Arg Gln His Asn Arg Ala Arg Gly Leu Ile Arg Arg
805 810 815
Ala Arg Tyr Leu Ala Thr Gln Cys Gly Ala Ala Pro Leu Leu Leu Arg
820 825 830
Leu Gly Ala Lys Pro Ser Asp Leu Gly Gly Ala Trp Asp Ala Thr Leu
835 840 845
Gly Gln Arg Ile Thr Ser Leu Thr Glu Ser Glu Arg Arg Val Ser Ala
850 855 860
Leu Ala Ala Val Gly Arg Thr Asn Arg Glu Ile Ala Asp His Leu Phe
865 870 875 880
Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys
885 890 895
Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Arg Glu Leu Ala Asp Val
900 905 910
Ser Glu Pro Ala Gly Arg Gly Asp Arg Cys Gly
915 920
<210> 47
<211> 2772
<212> DNA
<213> Streptomyces sp. GT1005
<400> 47
gtggttccgg aagtgcgagc agccccttat gaactgatcg ctcgtgacga cgagctgagc 60
cgtctccacc gggcactctc cggcgcggaa agcggacggg gtgccgtcgt caccatcacc 120
gggccgatcg ccagcggcaa gacggcactg ctggaggccg gagcggccaa gaccggcttc 180
gtcacccttc gcgccgtgtg ctccatggag gagcgtgccc tgccctacgg gatgctcggc 240
cagctcttcg accatcccga gccggccgcc cgggcgccgg gtctcgcccg gctcacggcc 300
tcgtgcgagg gcccgccgat cggcaccgac aaccggctgc gggccgagtt cacccggacc 360
ctgctggcgc tcgccgcgga ccggcccgtt ctgataggcg tcgacgacgt gcaccatgcc 420
gacggcgcat cgctgctctg tctgctgcac ctcgcgcgcc ggatcggccc ggcccgtatc 480
tccatcgtgc tgaccgagct ccgccgcccg acaccggccg actcccgatt ccaggcggaa 540
ctgctgagcc tccgctccta ccaggagata gcgctgcggc ccctcaacga gacggagagc 600
gccgaactcg tccgccgcca cctcggccgg gacacccacg acgacgtcct tgccgagacg 660
ttccgggcga ccggaggcaa cctgctcctc gggcacggcc tgatcaacga catccgggag 720
gcgcgggcca cggggcgccc ggaggccgtg gcgggcaggg cgtaccggct cgcctacctg 780
ggctccctct accggtgcgg cccgacggca ttgcacatcg cccgggcggc cgcggtactc 840
ggcgcgagcg ccgaacccgt actcgtccag cggatgaccg gcctcaacac ggaagccttc 900
gagcaggtct gcgaacagct gcaggacgga cggctgctgc aggacggacg gtttccgcac 960
ccggaggccc ggtccatcgt cctcgacgac ctgtcggccc tcgaccgccg gaacctgcac 1020
gagtccgcac tggaactgct gcgggaccac ggcgtggccg gcaatgtgct cgcccgtcac 1080
cagataggca ccggccgggt gcacggcgcg gacgcggtcg aactgttcac cgaggccgcg 1140
cgggagcatc ttctgcgcgg cgaactggag gatgcggtcg gatatctgga gctcgcccac 1200
cgcgcctgcg acgaccccgt catacgggcc gcgctgcgca tcggggccgc cgaggtcgaa 1260
cgcatctgcg atccgatgag ggccggccga catctgccgg agctgctcac cgcggcgcgc 1320
gcgggactgc tctccggcga gcatgccgtg tccctcgccg actggctggc gatgggcggg 1380
cggccggggg aggcggccga agtgctggcg acccagcacc ccgcggcagg ggacgaccag 1440
agccgtgcgc tgctgctcgt aggggagtta tccctcgcgc tggtccatcc cggcagatcg 1500
gatccttcgc gcagggccga cttcttcgcc gcgggcgggc tcgccgccct ccgtggcccg 1560
gcccggcagc gcgcggtcgc agacaaggcc gtcgtcgccg cgctgcgagg ccggccggag 1620
ctggcggacg cccatgccga gcgggtcctc cagtacacag acgccacggc ggaccggacc 1680
acggccatga tggcgctgct ggccgtgctc tacgccgaga acaccgaggc cgtccagttc 1740
tgggtcgaca gactggccgg tgacaaggag actcgcaccc cggccgacga ggcgatctac 1800
gccgggttcg gcgccgagac cgccctgcgc cgcggcgacc tgaccaccgc cgtcgcctac 1860
ggcgaggcgg ccctcggcca ggggctggtg cccacctggg gaatggcggc cacgctgccg 1920
ctgagcagca ccgtggttgc ggcgatccga ctcggcgata tcgaacgggc cgaccggtgg 1980
ctctccgagc cgttgccgca ggagacctcg gagagcctct tcgggctgca tctgctctgg 2040
gcccgggggc ggtaccacct cgcgaccggg cggcaccggg cggcgtacgc actgttcagg 2100
gagtgcgggg accggatgcg gcagtgggcc gtcgacgtgc cgggcctggt gctctggcgg 2160
gtcgacgccg ccgaggcgct gctgatgctc ggcaccgacc gcgccgaagg actccggctc 2220
atatccgacc agatgtcccg gccgatgcgg tcccggtcac gcgccctgac cctgcgggtg 2280
caggcggcct acagtccact gcccaagcgg atcgacctgc tcgaagaagc agccgacctc 2340
ctcgtcacct gcaatgacca gtacgaactg gcccatgtcc tcagtgacct gggcgaggcg 2400
ctcaacctgg tcagacagca caaccgggca cggggcctga tccgcagggc acggtacctg 2460
gcgacccagt gcggtgcggc gccgctgctg ctgaggctcg gcgcgaaacc gtcggacctc 2520
ggcggtgcct gggacgcaac gctgggacag cgcatcacct cactgacgga gtcggagcgg 2580
cgggtgtccg cactcgccgc cgtggggcgt acgaacaggg agatagccga ccatctgttc 2640
gtcacggcca gtaccgtgga gcagcacctc acgaacgtgt tccgcaagct gggagtgaag 2700
ggccgccagc agcttccgag ggaactggcc gacgtcagcg agccggcggg ccggggcgac 2760
cggtgcgggt ag 2772
<210> 48
<211> 262
<212> PRT
<213> Streptomyces sp. GT1005
<400> 48
Met Cys Ala Met Asn Gln Glu Leu Trp Leu Arg Gln Phe Phe Pro Ala
1 5 10 15
Pro Glu Ala Ser Val Arg Val Val Leu Leu Pro His Ser Gly Gly Ser
20 25 30
Ala Thr Phe Tyr Leu Pro Ile Ala Arg Ala Leu Ala Pro Val Ala Asp
35 40 45
Val Tyr Ala Val Gln Tyr Pro Gly Arg Gln Asp Arg Arg Asp Glu Glu
50 55 60
Pro Leu Arg Asp Leu Arg Thr Leu Ala Gly Leu Val Ala Glu Val Leu
65 70 75 80
Lys Pro Gly Leu Asp Arg Pro Leu Val Leu Phe Gly His Ser Met Gly
85 90 95
Ala Thr Leu Ala Phe Glu Leu Ala Gln Arg Ile Pro Val Ala His Leu
100 105 110
Ile Val Ser Gly Val Arg Ala Pro Ser His Pro Leu Thr Asp Thr Val
115 120 125
Arg Leu Thr Ser Asp Asp Asp Leu Leu Ala Ala Val Gly Ala Leu Gly
130 135 140
Gly Thr Asn Ala Asp Val Met Ala Asp Asp Glu Leu Arg Ala Leu Ile
145 150 155 160
Leu Pro Pro Leu Arg Ala Asp Tyr Val Ala Ala Glu Thr Tyr Arg Trp
165 170 175
Arg Ser Gly Pro Pro Leu Asp Thr Pro Ile Thr Val Cys Ile Gly Asp
180 185 190
Ser Asp Pro Lys Thr Thr Val Glu Gln Ala Arg Ala Trp Ala Gly His
195 200 205
Thr Thr Ala Pro Thr Thr Val Glu Val Phe Ser Gly Gly His Phe Tyr
210 215 220
Leu Val Glu His Gln Glu Gln Val Ala Glu Thr Val Ala Arg Gly Val
225 230 235 240
Arg Leu Val Thr Pro Gly Gly His Val Ser Glu Glu Pro Asp His Ala
245 250 255
Val Asn Gln Arg Arg Ser
260
<210> 49
<211> 789
<212> DNA
<213> Streptomyces sp. GT1005
<400> 49
atgtgcgcca tgaaccagga gctgtggctg cggcagttct tcccggcgcc ggaagcttcc 60
gtacgggtgg tgctgctgcc gcactccgga ggttcggcga ccttctacct tccgatcgcc 120
cgcgcgctcg ccccggtggc cgacgtgtat gccgtgcagt accccggccg ccaggaccgc 180
cgtgacgagg agccgctgcg ggacctgcgt accctcgccg ggctcgtcgc ggaggttctg 240
aagccgggtc tcgaccggcc gttggtgctg ttcggacaca gtatgggcgc cacgctcgcg 300
ttcgaactgg cccagcggat cccggtggcg cacctgatcg tctcgggcgt acgtgcgccg 360
tcgcatccac tcaccgacac cgtccgtctg acgtcggacg acgacttgct ggcagcggtg 420
ggcgctctcg gcgggacgaa cgccgatgtg atggccgacg acgaactgcg tgcgctgatc 480
ctgcctccgc tgcgtgcgga ctacgtcgcg gcggagacgt accgctggcg cagcgggccg 540
ccgctggaca cgccgatcac cgtatgtatc ggcgacagcg accccaagac cacggtggag 600
caggcccgcg cctgggccgg gcacaccacc gcgccgacga ccgtggaggt cttctcgggt 660
gggcatttct atctggtcga gcaccaggaa caagtggccg agacggtggc gcggggcgta 720
aggctcgtga caccgggagg acacgtgtcc gaggagccgg atcatgctgt taatcaacgc 780
cgttcatag 789
<210> 50
<211> 69
<212> PRT
<213> Streptomyces sp. GT1005
<400> 50
Met Asp Thr Thr Glu Trp Val Pro Leu Arg Asp His Leu Phe Glu Pro
1 5 10 15
Leu Pro Pro Phe Val Phe Pro Ala Ser Asp Gly Glu Asn Arg Thr Thr
20 25 30
Trp Arg Val Gly Gly Val Val Thr Pro Thr Pro Asp Pro Ala His Gly
35 40 45
His Ala Gly Cys Ala Ser His Gly Val Pro Thr Val Pro Gly Ala Arg
50 55 60
Thr Gly Cys Ala Pro
65
<210> 51
<211> 210
<212> DNA
<213> Streptomyces sp. GT1005
<400> 51
atggatacga ccgaatgggt accgctgcgg gatcatctgt tcgagccact tcctccgttc 60
gtctttccgg cctccgacgg ggaaaaccgg acgacctggc gggtcggcgg cgtggtgacg 120
cccacacctg acccggctca cgggcatgcc gggtgtgcct cgcacggcgt ccccacggtg 180
cccggggccc ggaccggatg tgcgccatga 210
<210> 52
<211> 474
<212> PRT
<213> Streptomyces sp. GT1005
<400> 52
Met Phe Arg Arg Phe Ser Ala Val Thr Arg Gly Asn Pro Ile Gln Leu
1 5 10 15
Pro Ala Gly Gly Gly His Glu Gly Gly Ala Pro Gly Arg Leu Arg Pro
20 25 30
His Pro Gly Arg Arg Pro Pro Glu Arg Arg Ala Gly Cys Arg Arg Ala
35 40 45
His Arg His Leu Arg Phe Leu Ile Arg Pro Ala Thr Leu Thr Ser Phe
50 55 60
Pro Ala Gly Arg Arg Arg Gly Gln Tyr Ile Met Leu Met Val Pro Ile
65 70 75 80
Ser Arg Gly Asp Ala Gly Pro Val Ile Leu Gly Asn Val Leu Pro Ser
85 90 95
Pro Val Glu Arg Arg Ala Thr Ala Arg Ala Ala Ala Asp Asn Val His
100 105 110
Ala Ala Leu Gln Arg Gln Asp Pro Ser Pro Ser Cys Pro Val Pro Ala
115 120 125
Pro Val Arg Arg Gly Gly Arg Arg Pro Pro Pro Gly Ser Val Pro Tyr
130 135 140
Arg Arg Arg Ala Pro Val Arg Thr Trp Pro Val Ala Ser Leu Pro Ala
145 150 155 160
Met Glu Leu Arg Thr Leu Glu Tyr Phe Val Ala Val Ala Glu Glu Arg
165 170 175
Ser Phe Thr Arg Ala Ala Ala Arg Cys His Val Val Gln Pro Ala Ile
180 185 190
Ser Gln Arg Ile Arg Ala Leu Glu Lys Glu Leu Gly Glu Pro Leu Phe
195 200 205
Glu Arg Leu Pro Arg Gln Val Val Leu Thr Ser Gly Gly Ala Ala Leu
210 215 220
Leu Pro His Ala Arg Ala Cys Leu Ala Ala Ala Ala Ala Ala Ser Leu
225 230 235 240
Glu Phe Ala Asp Arg Ser Gly Leu Leu Ser Gly Thr Leu Val Leu Gly
245 250 255
Thr Ala Gly Gly Leu Glu Gly Thr Ser Val Pro Arg Leu Leu Gly Glu
260 265 270
Tyr His Arg Arg Tyr Pro Gly Val Gln Val Arg Leu Thr Gly Ala Pro
275 280 285
Ser Pro Val Leu Met Ala Gln Ala Arg Ser Gly Glu Ile Asp Ala Ala
290 295 300
Val Ile Ala Glu Pro Pro Gly Gly Leu Pro His Gly Leu Gly Ser Arg
305 310 315 320
Cys Leu Leu Glu Asp Arg Phe Val Ala Val Leu Pro Ala Gly Thr Arg
325 330 335
Asp Pro Asp His Pro Met Thr Leu Ala Glu Ala Ala Arg Cys Pro Leu
340 345 350
Ile Gly Tyr Gly Ser Gly Ser Gly Ala His Ala Phe Val Arg Asp Ala
355 360 365
Phe Ala Ala Gln Gly Leu Gln Leu Asp Ile Ala Tyr Ala Thr Ala Asp
370 375 380
Ile Ala Leu Gln Val Thr Leu Val Ala Glu Gly Ile Gly Ile Ala Leu
385 390 395 400
Thr Ser Tyr Thr Asn Pro Leu Leu Arg Leu Asp Gln Arg Ile Val Val
405 410 415
Val Pro Leu Glu Pro Ala Ile Arg Leu Arg Lys Val Leu Ala Trp Arg
420 425 430
Leu Gly Asn Arg Pro Gly Pro Pro Leu Arg Ala Phe Leu Asp Leu Leu
435 440 445
Thr Glu Leu Pro His Thr Thr His Pro Thr Ser Ala Thr Ala Glu Ala
450 455 460
Pro Gln Asp Pro Gln Pro Ala Pro Gln Asp
465 470
<210> 53
<211> 1425
<212> DNA
<213> Streptomyces sp. GT1005
<400> 53
atgtttcgac gtttttctgc ggtcacccgg ggcaacccaa ttcagctgcc ggccggcgga 60
gggcatgagg gcggggcacc cggacgtctc cggccgcatc cgggccgacg gccaccggag 120
cggcgcgccg gctgtcgacg ggcgcatcgg catctgcgtt tcctgatccg tccggccacg 180
ttgacgagtt ttcccgccgg gcggcggcga ggccaataca tcatgctgat ggtgcccatc 240
agcaggggtg atgcgggtcc ggtgatcctt gggaacgtcc tgccttcccc ggtggaacgc 300
cgcgcgacgg cgcgtgccgc cgccgacaat gtccacgcgg cacttcaacg tcaagaccct 360
tcaccatcct gcccggtacc cgccccggtg cgccggggag ggcgtcgtcc gcccccggga 420
agcgtcccgt accggcggcg ggccccggtc cggacctggc cggttgctag cctcccggcc 480
atggagttac gcaccctgga gtacttcgtc gccgttgccg aggaacggtc cttcaccagg 540
gcggccgcgc gctgccatgt cgtccagccc gcgatcagcc agcggatccg ggccctggag 600
aaggagctgg gcgagcccct cttcgaacgg ctgccccggc aggtggtgct cacctccggc 660
ggcgccgcgc tgctgccgca cgcgcgggcc tgtctggcgg cggcagccgc ggcctccctg 720
gagttcgccg accggtccgg cctcctcagc ggcacgctgg tgctggggac cgccggcggc 780
ctggagggca cctccgtacc ccggctgctc ggtgagtacc accgccgcta tccgggagtg 840
caggtacgtc tcaccggggc gcccagcccc gtgctgatgg cgcaggcccg cagcggggag 900
atcgacgccg cggtgatcgc ggaacctccg gggggcctgc cgcacggcct cggttcacgg 960
tgcctcctgg aggaccgctt cgtcgcggtg ctgcccgccg gaacccggga cccggaccat 1020
cccatgaccc tcgccgaggc ggcccgctgc cccctcatcg gctacggctc cggcagcgga 1080
gcgcacgcct tcgtccggga cgccttcgcg gcacagggcc tgcaactgga catcgcctat 1140
gcgaccgccg acatcgccct ccaggtgacg ctggtggccg aggggatcgg catcgccctg 1200
acctcgtaca cgaacccgct gctccggctg gaccaacgga tcgtcgtggt accgctggag 1260
cccgcgatcc ggctgcggaa ggtgctcgcc tggcggctcg ggaaccgtcc ggggccaccg 1320
ttacgggcct tcctcgacct gctgacggag ctgccccaca ccacgcatcc gaccagcgcg 1380
accgcagagg ccccgcagga ccctcaaccc gccccacagg actga 1425
<210> 54
<211> 111949
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 54
actgggctca tagtcaactc cgcgcatcga tagaacactt cgatttgccc gctcccgcag 60
ccggccgcca ccgtgaagga catcccgcgc atcccgcctc acgcgactga ggagtccaga 120
catggcgaag gttctgtgcg tgctgtacga cgaccccacc ggcggctacc ccaccgtcta 180
cgcccgcgac gatctgcccc gcatcgaccg ctaccccgac ggccagtcgg cgcccacgcc 240
cctgggcgcc gacttcaccc ctggccatct gctcggcagc gtctcgggcg aactgggcct 300
gcgcgccttc ctggagagcc gcggccacac cctggtcgtc acctccgaca aggacggcga 360
gggctcggtc ttcgaccgcg aactgcccga cgcggacatc gtcatctccc agccgttctg 420
gcccgcctac ctcaccgccg aacggctcgc cgccgccaag aacctcaagc tcgccgtcac 480
cgcgggcatc ggctccgacc acgtggacct ggacgccgcc atcgagcacg gcgtggccgt 540
cgccgaagtc acctactcca acagcatcag cgtcgccgaa cacgtcgtca tgtcgatcct 600
ggcactcgtg cgcaactacc ttccctcgca ccggatcgcc aacgagggcg gctggaacat 660
cgccgactgc gtggagcgtt cgtacgacgt ggagggcatg cacgtcggaa cggtcgccgc 720
cggccgcatc ggcctcgccg tgctgcgccg cctggcgccc ttcgacgtca agctccacta 780
caccgaccgc caccgcctgc ccgccgacgt agaagccgaa ctgggcctgg tcttccacga 840
gtcgaccgcg cagatggtgc cgcactgcga cgtggtcacc atcaacgcac ccctgcaccc 900
cgaaacccag ggcctgttca acagcgacct gctggccacc atgaaacgcg gcgcctacct 960
catcaacacg gcgcgcgccc gcatcgtcga ccaggacgcc gtacgacagg ccctggaaag 1020
cggccagttg gccggatacg cgggcgacgt ctggtacccc cagcccgccc ccgccgacca 1080
cccctggcgc accatgccgc accacggcat gaccccacac atctccggct cgtccctgtc 1140
tgcgcaggcc cgctacgccg caggaacacg ggagatcctc gaggcgtggt tcgacggcaa 1200
acccatccgc gaggagtacc tcatcgtctc cgccggcgcc ctcgccggaa ccggcgccca 1260
ctcctacgcc gtgaacgaca ctccggcaaa gagctgagcg ggccacaccg aacccgtcgc 1320
cggccccagc ccacgggggt cggcgacggt ccacaaagtg cagttccagg atccagtgga 1380
ggcgaaagcg ccgcccgacg gccgtgcgat cgcgtggctg tcgccgtcgg attcgaccgc 1440
gctcccgagg gcgggctcgg ctcacggtcc gcgccagagg ttggcgaagg cggagttctc 1500
gatggtccgc ctctggcgta cggcctccag ctccatcacc gcgtcgtgga cggcggccag 1560
cacggtcgtc accgcctcgt catcgaggcc gggctcatcg tcggatcgtt cgtcgtcgat 1620
gcccacgacc gaggcgaggg aggccaggac gggttccttc tctttccagc ggtcggctgc 1680
acggcggcgc gcgggcgtat cgaccagttc cacgcgctgc gagccgaagc ccaaccggcc 1740
gctgcgctgc ggcctcagct catcgttctc ctccagggcg gcctggtacg cggccgagag 1800
gtctcggccc cggcgccaca gccagtcctc gatccgctcg tacggtgcct gccgagtgag 1860
ccctgccgcg gcctcgccca tgaaccgatc gtccagcgtc ggctgtccac ccggcacgat 1920
gcggtcgccg tccacgacca ccgccccggc accgatgaga tcgatcagct cggctcccgc 1980
gagtgcgagg gacaggtcgc cctgtcccac ggaatgcttc aggtccatgg caacgatgaa 2040
caagtcttgc gccgtggtca tgaacggctc ccctcgcaga catcaacaaa ggtgcatccc 2100
cacccaccgg acccgcgtcc gaggccggcc cggcggcggg gcaactgtca ccaccagtat 2160
cgccccgccc gcgcagccga agcctttcgg ctgcgctgtc ctgctcaaag ctgtactgca 2220
cctctacgcc tggtccagca ccggctgcca aaaccgcagt gctcaggcgg ggcagatggg 2280
gaaaacggct ggtgtggtcc aggtacgagg catccataac tgtcgtcttg cccgcgccat 2340
tcgcaccgat cgggacccgg aaacgctcac acggctcaag tggtcagacc ggcgctggtc 2400
agccagatgt gttcgcaggt cgcggatgcc ccttgcagcg tctctcggga ctcctgtgag 2460
gcgtggtaga aggtccgctc gatcatccag cacagggcgc gtgccatcgc tgaggcttgt 2520
tccggttcgg tgccggactg gatgccggcc cgttccagga cggcggtgat ggccgtgatg 2580
aacaagtccg ccgtatggct ccacaactcg ccgatctccg gcacggtcaa cgacaggtcg 2640
atcgccgtgc gcatgaccag gccgtgctcg ttccacagct ctaccgtgcg ctgcatggct 2700
tctgcgatgg cctggcgggg ctcgtcggtc tgcgcggtgg tccgggaccg ttcccacaga 2760
tgctcgacgg tacgcgccac gagtgccacc accacttctt gcttggagcc gaagtagaag 2820
tacagggcgc cgcgtgtgat gccggcgccc tgggcgatgt cgccgacggt catggcgttg 2880
tagcccttgt gcgcgagcag ggcttcgcag gtgtccagga tggcccgctc ccgcagatcg 2940
cccttgcgtt cggcgctgcg tcggctccgc gcggggtgct ggccgggcat cagagctgag 3000
caccctcgtc gaagtcggtt gtgcgggaga gcgtctccca tgcacggatg tcctcgtcca 3060
cggcggcgcg cgcagtggtg accagccgca gcgcgtccga gcccaggacg aggtgggccg 3120
gcggctggtc gaccgaggcg atgcgcacga cggcgtctcc ggccttggcc gggttgccga 3180
gctgattccc gctggccttc tgccgcgctt gacggatggg ctcgaacaac tcgtcgtagt 3240
cgtcgacggt ccgcgcggcg cgtgtcatgg accgtccggc ccagtcggtg cggaaggagc 3300
cgggctcgat cgccgtcacg tggatcccga actgtgcgac ctccttgccc agtgcttcga 3360
ggatgccttc cagggcgaac ttgctgccgc agtaggcgga catgccgggc acggccatga 3420
gcccgcccat ggaggtgacg gccatcaggc gtccgcggcg gcgtcggcgc atgtggggca 3480
gcgctgcctg cagggtggcc actgccccga agacgttgat ctcgaattgc cgccgcacct 3540
cggccagcgg agtttcctcg aaggtgccct ccaagccgta gccggcgttg gcgatgacga 3600
cgtccaaggg accgacgcct cgctccacct ccgtgatcac atccgagacg gcgtggtcgt 3660
ccgtcacgtc caggatgcgg ccgtgagcgt caccgggctt gagcccctcg aaggctcgcc 3720
ggtcctcctc ggagcggacc gtaccgacaa cggtgtgacc ggcatccagg gcagcctggg 3780
cgaaggcacg tcccaggccc gtgctgacgc cggtgatgag ccagttctgc ctctgcattg 3840
ctcctccagg aaggtctcac ggggagcagg gctgctcctc ttcccagaaa gtctacacgg 3900
tgtcgatttt taccttcgca gtgttggttc tggttcgctc aacggcatca cgcctggccg 3960
ggggcgatcc ggccgcaccg ggaccggggc ccaccggtgc acgcccctgt gcgccctggc 4020
aggtgagctg cggtgccgtc ccgcgaagtc attccagccg tcaccgccca catccggcag 4080
gtcctggcct ggcatgatct ggcgtcgcgg agcatcaccg ggatgtcgag tcgcggtgac 4140
tgatggacgc ccccacgtgt ccgtgggctc gacagcgaga cgcctgggag gttcccgcgg 4200
gagcactact gacagtcaat gcgcggtgtc gtgaagatcg acagtcgtga actcgcggtc 4260
atgccgttgc cttagggcag gctgagctct tcgcgggcgc tcgttaccga gcgcaagacg 4320
ccgtcggact tggtcctctc ggccaggtct gttgcttcga ggagcatcgc tgccgcatcg 4380
tcgcgccgtt cttgctgagc ggcgagatag accagaccga tcaggtttgc cgcgactccc 4440
ggcaggaacc ccagctcccg gcgcaggcgc gtggactcct ccaggtgcgc gcgggcctct 4500
tcgaggcgcc cagcgatgtg gtcggctatg ccgaggtgcc gtagagcgta ggacatcgtc 4560
agctggtcgc ctgcttgggt ggcgagctcg agggcgcgtt tgaaggcggg cagcgcggtg 4620
tcgttgtcgt cgcgtacgac ctggtggaag cagccgatcc agaagaccgc ctcgccctgg 4680
cctcgcgcgt cgtcgactcg gccgtagatt gccgccgcac gctcgaacag ctccagctcc 4740
agttccagct ccagttccag ctcccgttcg tcttcgaccc gatccgccag gtagcgggca 4800
tggatcacgc ggccgcgggc gagcgcgaga tccgcctcga ccgcatcgag gccctgctcg 4860
gctgtcgtca gcgcaccggt gtcgccgccg aagacggcac gctcatagag gagatgagcc 4920
tgcgcgattc gctcgtccac agtcattggg cgagcgtaac gaccctggac gaactggcac 4980
agatgccgag cttcttccgg cctccggtgt tcgcaacggt aggccggttc cggcggggca 5040
tccatcgatg atgtcgctgc ggtacggatt tctcgcaggc cccggcgaca cctttgcgag 5100
catgtctatg cagcatgagt aatcctcccg ccggatcatg ccactgggcg cgaatcagaa 5160
gcgctgagtg aggacctctg cacccagaag ccctttgggg cacttgacga cgagagtcga 5220
gctgaggcgc aggaacgaag tcgagcggac gctcaacacc ctcaagaact cccgctccgt 5280
agccacgagg ttcgacgagc gcgcctatgt cttccagggc accgtgaacg tctcagcgat 5340
ccgcctctgg cttcggggat agatccatta tccctgcgcg ggaacgacac ggtgagcgca 5400
ctcaacccgt accgcttagc gcgcagttca tcagcgggcc cgtggctggg gtcgggccgt 5460
tcgcgaacac cgcccgccgc cgcgaagccg atcgacgctc aggcgcggtt ggcgcggatc 5520
tcgtcgtggt ggtcggcgac ccagccgatc agttgcatga cgatctcgtg caggccgtgg 5580
ccgagcgggg cgagggcgta ctccacacgc ggcggtacct cggcgtaggc ggtgcgcgtg 5640
atcaggccgt cctccttgag ctggcgcagt gtgtgggtga gcatgcgctg ggagatgccg 5700
gggatctggc gctgcaggtc ggtgtagcgc agtggaccgt cttccaggac ggcgatgatc 5760
agcatgctcc acttgtcgcc gacccggtcc aagacctggc ggatgaaggc catgtggtcg 5820
gcggggatgc tcgcgcacgg cccgatcgcg gccgccatct ccgtaccaac gctgtcctgc 5880
atggcgccca ttcctctccg tcgcgcacac cggtgtgcct tttgtaacgc cttccatact 5940
ggcgcatcat ggcgttacga acaaatgaga ggaattggag gtcaggccgt gaaggtagaa 6000
atctgggcag aggtcacgtg cccctggtgc gggctcggca gccaccgtgc ggaccgggcc 6060
gtggagcggt tcgagcacag cgatcaagtg caggtggtcc accgctcctt cccgctgggt 6120
gccggcttcc ccgccgaccg cgcggtcagc gtccgcgagg ccctgctgag caagtgcggg 6180
gcaagaaccg tgaagcctgg gacgcggtct tccgtacgta cttcggcaag gccgagccgg 6240
tcttcgctct ggacgatctg ctccggctct ccgacgagct gggcctggac cgtgatctga 6300
cgcgtcaggt gctcaccgag cgccgctacc gtgcccgggt ccaggaagac gcccgccgcg 6360
ctcagcgcct cggcgccacc ggtgccccgt tcctcgtcgt cgacggccgc tacggcgtcc 6420
tcggtgcgca ggacagtgac accctgctcg acctgctgcg taccgcctgg gacgaaaccc 6480
acctggtcac cctcgccccc gcgggcgacg ccccgggctg cggcctcggt ggccgcgccg 6540
tcccggcccg gccctgaccc gtcaccccaa ccccaccacc atctctgtga aaggcacaac 6600
agccatgtcg tacctgctgc acatcgactc ttcctcgctc ggcgaggcgt ccgtctccca 6660
tcaggtcgcc cagtccttcc gtgaccagtg gcagggcccg gtcgtccacc gcgacctcgc 6720
agcctcgccg gtgccgcacc tgagcgccgc gggcatcacg gcccgcatca ccgacccggc 6780
ccagcacact cccgagcagg cgaaggcggc cgcgctccag gacgagctga tcgaggagtt 6840
cctgggcgcc ggcgcgtacc tgttcacggt gccgatgtac aacctctcga tgccgtcggt 6900
gttcaaggca tggctggacc agatcatcgt cacggaccgc accctgatct tcgacggccc 6960
ctccccggtc gcgggccgtc cggccgtgct gatctccgcc cggggcggcg gctacggccc 7020
cggcaccccc aacgagggcc tcgactacgt ggtgcccacc ctggaggccg tcctgggcca 7080
cgacaacctc ctcggcctgg acgtcaccac cgtgataccc gagctgacca tggcccccgt 7140
gaatccggcc ctggccccgc tccttcccct gcacgaggca tccatggccg ccgcccacga 7200
ccaggcccgc acgctcgcca cgaccttcgg cacgccgcgt gccgcctgac gcgtctctcc 7260
aggtggttcc tctgtcccgg tgaacggcgg aggcttcgag cgtgaacgtg gtcgtgggct 7320
ggttcgcgcg ttccgcgcgc aaggtgcgca cgacgccagc gcgttcacca gggccgagga 7380
tccggatttc ctcatcgcct tcggtgcgga cccgttgacg tccggtgtgc cggttggccc 7440
acaagctccc gcaaccggct cttgagcgcc ccaatcggat caaaggcgcc cacgagaccc 7500
agaggctggc tccgcgctac cgggcgaccg gcatcgttga gcatgaagag catgccgcgc 7560
ggttcgtatt ccggaagtat cagaccgttc ttccgagaca gggcgcgagc tctctcccac 7620
tccgaccggg aatcggtcgt cctgggccgc tgcgtacgcg aaccccgcac ctttccggat 7680
cgcccgggaa gcacttccgg gatttccagg tgttccggca tgacgaacac cgtccgcccg 7740
aggcaatcgt ggtcacagag ccaggccatc tcccactgca cccactgagt cgcaccggga 7800
atcatcacca cgtaccgcgc tgcggcggcg agctgcgcga acagaaccct ccacttgtcg 7860
tccggctgct cctcgatccg ggcgactccg gggccggaga tcgaaggccc cagggcgacc 7920
gtggggagct cgtcccccaa ggccgcgtac agcaccgtct cgaagtcgag gtgcggattc 7980
cagtggctcg tctttgggac ggggtcgtcc cacggcagca gcatgtcgtc gggattcgga 8040
tcgagttcga agcggtacgc gggccgggcc ggcaggtggt cggtcaccgt gaaggacctg 8100
aggtagagca cgaagggctc caccgggcga tcatgcgcga cgccttcctt gatcgaccgg 8160
gcccgctgac tgcgccagtc atgcgtccgt tccaggtcct tcgggtagcg gaggcggagt 8220
cccagagccg ggattcgact caacgcggcg atgacaccca caccgcacag gacggctgcc 8280
ccctgcagcc agccgtccag gtccgtcagt gtgtttccgc tccacaggaa aacgtagagc 8340
agaaagaaca agggaagact gaaggagtgg taacgcaccc agaccaccga gccgttgtac 8400
ggattcaccc cccgcagccg tacgccgaag ggaaagtaga tcccggccgt cacgaaacag 8460
gcggcgaaaa cgctccaggc attccagtgg aaggtgacat cgaacctccc caccacggaa 8520
tgccacgcca gggcaagacc tgcggaatac ggataccaca gcaacacggt gagccacgtg 8580
ccccatgaca cacgcatgcc gaacctggct gcgcccgcga ccctcacgag gggcaccgtg 8640
ggcggcagga cggcgaggct gacgaccagg acgagtatgc gggcccaccc gggaagccac 8700
acggacatgg cgatggtcac gagcaagggt gtcatcgcac tccccctccg gtccgcttac 8760
aacacgcgtt gggtcatgag gcccagcaga cggagttgct cccccttcag caaggcgaac 8820
gactcacgga cgtaggtcac gtatggggcg cccggatgcc tgatcagcac ctcggggcgg 8880
gcatcgccag cagcaggctc ggccagagcc acctcgcatg cggcgacatg ggagcagaac 8940
agccggagcg gctccggcaa ctccggttcg accaggagat ccgcgtgctc gatgatcaga 9000
tcccgcatct tccggttggt cggcatgaat gcgtaggtga accagcggtc ccaggtcgca 9060
cgttcctcct gggacggatc gaccgtccgc cggtgcgcac gggacggcag gaccgatcgc 9120
tgcagcgcct cccatatgtg ctcgttgctc tccacgaggg cgttgagcgg gccgtagagc 9180
aggcgcagtt gttcgccgat gcgggtcacc cgggtctgcc gacgctcgaa gcgcagctgg 9240
ctccactggt tgagcatgaa ggccacgatc gctaccacga gtgtcgcgaa ggccgtgatg 9300
acagccgcta tcatccacgg ccccttctac cgagagtgac actcgcatgg cacaggggca 9360
tggctcgtat ggttccacgg ccggcggcgg cctggcgacg ttcgtcgaaa ccaggtgatc 9420
ccaggccctg agtatggttc gtggttacag tggataggcg gtcggcttac ggatgctcag 9480
cgatggctgg gcccgccggt cagtcaatgc cgtcgatgcc gtcgatgatg cggaagtcgc 9540
gctcgacgcc gtcggggagg gccaccagcg ccttctggta cgcctcgctc tcgtatgccg 9600
cgacggcctg ttcaaagctg tcgaactcga tcaggacgac gcgttgcgtg attccggcct 9660
cgtgagcgac gactcgacca ccatgagacg ggaggcggga caggacgcgc ccgcccccgg 9720
cctggacggc tggaccggcc agttggtcgt aggcagtcag cccctcaggg tcggaaatgg 9780
cggggtagac actgacccag tagcccttgg ccatggattc ctcctgtgtt cggacggaca 9840
cgtccgacgt cgaattgaca ctcagatcga tcgatcccgg cgaccgttac cgcggtcagt 9900
ggcatcgcca tatgcggagg ctagggcttg atgtgcggtc gagggaaaga ccggtacgga 9960
atagactcag aacggatcgt tatcaatcgt cggggagggt acgtggcgcc ggatacggtg 10020
agcctgcggt acttcctggt gctggcgcag gagttgaact tcacccgcgc ggccgcacgg 10080
atcggtatcg cacagcccgc actcagcgcc cggatgcgcc gattggaggc gcaactcggt 10140
acggccctgc tggtccgcga cacgcgtagc gtcgaattga ccacggccgg tacggctttg 10200
gcggagtccg cgccgcccgc gctggcggcg ctggaccggg catgggacac cgcccggagc 10260
gcggcggccg gtgaactggg cacgctgcgc atcggataca gcctgagcgc cggtgccgag 10320
acggtacctg ccctggtgga caggctgatt cgcgacaaca gcggactcga ggtcggcgcg 10380
gtcccgatgg cgacaccgga gatctccccc gcggtcgccg acggccgcat cgatgccggg 10440
atcacccgcg gtgaacagcc gggccgcggc gtgcgccggt tcctgctgcg gcgtgcgcgc 10500
atcggggtcc agctggcgca gcaccatccg ctggccgaac accccgagat cgagatcgcc 10560
gacgcggccg cgtatccgct gcgactcccg gcccgtgcgg ccaaccccgt gatccacgat 10620
cagctgtccg cactgttccg agacacccga ccacaccccc gattccacac gcccgcagtc 10680
tctttcgaca tgtctcagcg cgacctgcgc gacggggtca ccctcgcccc ggccggagaa 10740
gccgcggcca cggcacaacc ggccggtctc acctggcgac cgctgcgagg cgcccccagc 10800
ctgacgatcc acctggtcct cccacgcgag cagtcgccgc tgcaccgccg catccgtgcc 10860
gtcgccaaaa ccctggcgca cgagctgcac tggctaccgg actgacgcgc aagaggccaa 10920
gcggctcttg acgcagggtt cgccgacggc ggctcaggag gaacgggcat tccggagggc 10980
ggcggcgcgc atgcgggcgt aactggcgag gtccttctgg tacgtcggcg tcaggtccgc 11040
ctcgacggcg cgctggaccg tgcgcacccg ctcggcgaaa cggattcgtc gctggcaccg 11100
cgcgtcctca acagccaggg cctgctcgtg cgcaccgatg cggagcaggt ccttccgggt 11160
gccggacgag gcgttcaggc tgtcctgaat gtccttggcc ggtgcgcgga gggaatcgta 11220
cggtcggccg gtcgcgcgca tgcaggcgga ccagtcgcgt tcggcggcca catagcggga 11280
actgctctcg acgcccgcca gcaccaggtt gacgagccct tgcacacgtg ccgaggtctg 11340
ccgccaggtc gcaccgtaca actgccgctg ggcctcggcg acacatccgt cggtcggata 11400
ggtcaaggtc gcgccgtccg gcagccgcag ccgacgccga ccttccttgg tgccctcgac 11460
cgctgcgagc cagcgtgcgc gctcgcgtac ggacaggtcc cgcgtcgcgc gggcgtagac 11520
gtcgtcggta gtcgctgccc cggaaagagc ggaggagacc atcccgtacc cgtcctgccg 11580
ggccacttca ggggtgagaa gtccgtacgg gttggcaggc tcggtccccg gcccggtcgg 11640
cacctcgacg tagcgcatcc cccgctgccg catacaggcg cggactcgcc gctcctccgc 11700
ctcgtgcagc agccgggact ccggcgcgga gaactgtgcc acgccgcgca gagggacggg 11760
cggggagtca gcgggcggcg actggcggac cggcgccgaa gcacagccag ccgccagcca 11820
gcccgccgcc atcaggagca gcagcctgga acgggtcaca cacaccactg gttcgagtac 11880
gtgtggtgcc agaaggccgt gccgttcagg ttcaccttgt ctccgcgcag cattcggtag 11940
gaccgtccgc cgtagttcag ttcgctgtag accgtcacgg cgcactgggt gccgtggttg 12000
tagagggact cggcaccggc gaacttcgcg tactgcttga ggttggtgtt gttcccggcc 12060
acctctcccg ggtctccgac accgttgagg ttgaggtagg cacacagctt ggtggagggg 12120
caggtccagg ccgcttcggc gggcgcggcc gtcgccgcca gccccgcagt gaccagggcg 12180
gcagcggccg ccgaggaagc gatcactctc ttgacgcgca tggcgatcct ctctctgagg 12240
cgagtgtgct gggatcttcg gctccgcgcg ggcggcacga cagaacgcaa ctgccgccgg 12300
accggaccag gatgagtgtg gcgccgccgg gaaggcctgc cttctccgaa ataagccatt 12360
ccgcgcaggt tatggagaac cgggcgcccg gtcggccgcc caggaacagg gctacatccg 12420
tgagcatcgc cgtcagggat tcggtccgcc gtgcgcagcg gcgtgtcagc gccggtatct 12480
gctcggcgaa cgtccggtgc gagcatgcgg tgcacgagca ggtgaaccgc cttgcccgga 12540
gccggacttc caggcggcgc acgcgacgtg aaccgccccc cctcgccacc ctcggcctcg 12600
catggtcacg aaccggacat cacgcgacta ctccgaagcc ctaagggacc agcaactaca 12660
ccaagcgcaa acgactttgg accagccctg atcagctccg gcgccgtacc gcccacatcc 12720
gggaacgaac acagatcgaa accgcacatg tacgtctcct ggtggaaata ggagaatgag 12780
ggtggcggcg cctttggatt ctcactctcg tagtagagct ggaagatgtg cgtccccttg 12840
gagagaccga cggtgaaccc cggccccgta caccccggcc agtccccgta tgccaccgcg 12900
aaggacagcc cctcagcgga gccgtaccgc accgccgtct gcgcgggcgc atccttgcgc 12960
cgcaggaaat cctccagcgt cccgcccgtg tactcaccca acagacccgg ctcaccccgc 13020
gccaggcgcc gcaccagctc atccggctcc agcccgcggg ccagtgtcac gcagtacccc 13080
gcccacgtca cgtcgctgtt cgccagccac gtcagtccgt cactcacact ctctcccatg 13140
ccgaaggggc cctgcgcacg gtacacaccg ctcccagagc ccccgttgag caatcaagaa 13200
acatctgagg tgctcacgtc gtcgggcagt ctcctctcga ccgcgagggc gacgacggat 13260
ccgggctccg cctccattcc gcgccggaaa gcccgctcga agagcgcttc gccgatggcc 13320
gcacgggctg tccgccagca ggcctcgcgc acctcccgca gctcgggcat gccccgttgg 13380
gtgtgcccca ccgagcgcca gcacgattca ccggccccgg acaccagcgc ggccgtctct 13440
ccacggccct gggccgcggt cgccgcggcc agcaggtcca ggccgagggc cacgccgaag 13500
ctgtccccga gccgccgttt gcccgccagc atgtcgcggg cgtgctcggt ggctcgggcc 13560
ggttcgccct gggtgagggc gatgagggcc aactggtagt cggtgtaggc cgtcgtccag 13620
cactcctcgc gcgccacgca gtcggcccgc agggagatgg ccttccgctc cgcctcggcc 13680
agtcggccga gaccggtcag ggcgaacacc tccacgaggt gacaccgcag caccgagggc 13740
gaggcatcgg gcgccgcggg cgaggtgtcc gccgccgagg gcatctgccg gaaagcctcg 13800
acgacggcgg cgtacgcctc ctccgcccgg ccgcagagca ggtgggtgat gcccagtaag 13860
taggcggccg ccagccgtcc ttcgctgtcg ttcgagcgtg ccgcgtcgcg cgcgcagcgg 13920
cgcccgatgc ccgcggccac cccgtgatct ccctgcaaga gggtggccac gcccagcgcc 13980
cactgggccc tggcccgctc cggggtgtgg gaccgcgaca gcggcaggac ctgggtgagg 14040
taggcacgtg cttcgcggag gtgaccgcag cagctccaga agaagccgac cagacccgcc 14100
agttcggccg cccgcccggg tgcggtgtcg acgagatggt ccagcgcggc gcacaggtcg 14160
gtgtgggccg cgtcgatcgt ctggtaccag gtgacctggt cggctccgag ccagccggcg 14220
tcggcggacc gggccagtgc gaggaagtgc tcggcgtgcc gagcctggac ggcttcgcgc 14280
tgccgcagct cgccgagcca catccagccg tactcgcgca cgctctccaa caggtgcagc 14340
ctgccgtccg ggcggcggct gagcacggac ttggccgtca gccccttgag cgcggtgccg 14400
accgccgccg cggacagcgg tccccccgag cagatgctgc gggcggcgtc ctcgtcgaaa 14460
gttccccgga agaccgagag gcgtgcccac agcagcctct ccagcggctc gcacagttcg 14520
tggctccacc ccatggccgt gtgcagcgag cggtgacgcc ggggccaggt gggcgcggcg 14580
gccgacagcg ccgtccgctg tgagcgcagc cgacggcgca actctgcgag ggtgtggtgc 14640
atcagttgtg cggaggcgag ctccagggcg agggggacgc cgtcgagcag tcggcagatc 14700
tccttggcgt cctcgttctg ctgtgcgctg cgcacccgca gcgcgggagc cacggcgacg 14760
gcacggtcga cgaagagggc gaaggcgtcg tcgccgtgcg gcagggggtc gatctcgatg 14820
acggcttccg cgggcgtctc gagccgctgc ctgctggtga gcaggaccgt gaggcgggga 14880
cagcccgtga ggagttcggc gagcagatcg cggcaggccg gcaccaggtg ctcgcaggag 14940
tcgaggacca gcagcacgcg ccggtcggac agccagccgc acagcgcttc gactggtttg 15000
ccgtgcgtgt ggtccgcgaa cccgacggcg tccgccacgg tcccgaccag ccgccgggcg 15060
tccggcagga cacccagatc ggcccaccgg acctcgccga gcgcctcggc ctcccggccg 15120
gacagggagc tcagggtgta cgcggcaagg cggctcttgc ccactccccc gaggccggtg 15180
agggtggtca accggtgcgt ggtgatcgtc gagagcagtc tctcccgctc tcccgcgcgc 15240
ccgacgaaga ggtccgtgta ctgcggaatg gtgcctaaca tccaggcatt ctccaccagt 15300
taccgcccgc cgacacgcgc cttcgcccgg cgcccctccc gtgcggcagg tcagtggcac 15360
cgccttcggc gctctcggac atcagcggcg cgggttcagg tggtgacgcg ggccacggcg 15420
gctacggccg cgggcagttc ctcgttcctt gaggacgaag ggggaccatt accgaggccc 15480
gaggcccccc tagagacatg ctccacggcg atctaggggg tgtgcatcgg ctccttaggg 15540
ggctgacggg tcaacggccg cctctttatg ctcagggcgt tcccgtatgg gggaattccg 15600
cttgtcatgt cggttccgcg cacgccctga gcgcggcggt cgtgcgcgtc tcctcgtcct 15660
gcggtaaggc acccgccagc tgatcgtgcc tgtctcatcc gactcagcat gtccagcgac 15720
acgttccacg gttccccctg tccggcagga gaagtgtcgg cccgagccgg ccgggtgcgg 15780
ccggctcggg ccatcccgac gaaaggacga tgacatgacc agtggggtgg cgttcctctt 15840
ccccggccaa gggtcgtacg tgccgggtgt cttcgccggt atcggcgcgg acgccgaccg 15900
gatatcggcc cgtgtcgcgg agatcgacgc ggtgaccgcc gagttccaac tcgagccggt 15960
gcagcctctg ttgttctcgc ctgacgcccc ggccctggca cagctgctcg agtccgatca 16020
cgagcggctc gacgtggcca tccttgcgac gtccatcgcc ctggcggagc tcctggagtc 16080
ccggtacgag atgcgtcccg atcatgtcgt cgggcacagt ctcggggagt tcggcgcgct 16140
ggccgtcgcc ggggtgttca cccccggcga ggccgccagg gcggtctgtg aacggcacgc 16200
caccctgcgc aaggcgccgc cgcccgaggg cgggatgctg gcggtgaacg cggacacggc 16260
ccgtgccgag gagctgatcg cttcggcgaa ggccgaggcg tcggccgtgt cggcgcggaa 16320
cgcgccgagc cagacggtga tcagcggcac cgaggcggac ttggtcaagg tacggcagct 16380
ggcacgagag gcggagatcc gcacgtcccg gctgcatgtc cccggcccct tccacgtgcc 16440
gcagttggcc gacgcgagtg ccctctatgc gaggacgatg cggaacgtgc ggatgtccgc 16500
gccccgcgag cgcttcttct actcccatgg cctgggccgc ttcctgaccg cgcgggacga 16560
cgtcgtcgat ctgatggtgg ccgacatgac ccgtccggtg cgcttccacg acgccgtgcg 16620
cgcgctgaac gccgaggggg tcacgacctt cgtggagtgc ggcgcgctgg acgtcctcac 16680
ccggatcgtg tccgggtcac tgccccgtgc ggtgaccctg gcaccgctcc gcgaggccat 16740
ggacacgtcc gatctgtccg cccggctgcg gaccgcccag ccgtcggccg cggccgggga 16800
gccgacgccg accgccgcgg ccgatgcgga ggtcctcgaa ggagtacgcg cggtgtgcgc 16860
cgagatcctc gagtatccgt tggacgtggt caccgccgac gccgacttcc aggccgatct 16920
cggagtcgat tccctggcga tgaccgaact gcaggaacgc gcgttgcgac gcttcgactt 16980
gcaggacagg gtccacgacg ccaccgcggg aacgtatgcc acggtcgccg gtctggccct 17040
gtacatcacc ggcctgctgc gcgagggcgc caccacgggc gccgaacagc ggtgagcgcg 17100
tcgtgacctc cggcagcccg gacgacgcgg gcacacacgc ggacaccgtc gccgtggtgg 17160
ggatgggcat cgcggtcccg ggagcctgcg acacggacga gctgtggaag ctgctgagcg 17220
gggaccggcc cgtgttcgag gagcctgggg accgcttccc gctggactcc ttctggtccc 17280
ccgaccccgc cgccgaggac cgcgcctacg tacgcacctc gggcttcctg cacgacttcc 17340
ggccccaccc ccgcctcgcc gaggagatcg cggcgggcac cttctcggcc gccgaccaga 17400
acccggtctg gctgcggcac tgcctcctgc gggcacggga caccgtcacc gcccgcgaca 17460
ccgaccggta cgcctactac gtcggcagca gcaccctcgt cgggcagcgc accgacgagg 17520
cgaccctggc cgagtccgtc gccctgcaca ccgccgagcg cctgcacggg gacgatcccg 17580
tccggcgcgc cgaggcggcg gaacggctgc gcgccctgct ggggcgccac cacgggcacg 17640
gcgccgggcg gccggtggac acgctgcccg accgtgtcgc gcgggccgcg gccgccggac 17700
tgctgcccgc cgactgcgag ttcgccgtgg tggacgccgc ctgctcatcc tcgctctacg 17760
cgatcggcct cggcgtcgcg agtctgctgg ccggtgactg cgacgtcgcc tactgcggcg 17820
gggtgtcggg cgtgacgccg cgctacaacg tcaccttctc caaactgcgc gggctgagca 17880
ccggcgggga cgtgcgtgcc ttcgaccgcg gggcggacgg aaccctgttc tccgacggcg 17940
cgggcatcgt cgcgctcaag cgcctggggc gggccgtcga ggacggtgac gccgtgctcg 18000
gcgtcctcgt ggggttcggc ggatcctcgg acggcagggg cacggcgatc tacgccccca 18060
acccgaaggg gcagcgccgg tgcctcgacc gcgcctggcg gcacgccgga ctgaccgccg 18120
acgacatcga ctgggtgatc gcgcacggca cgggcaccgc ggtcggcgac gccgtggaac 18180
tcaagaccct ggccgaggcc accgaccccg gcggcctctg gtgcggatcc aacaagtcgc 18240
tgctcggcca caccggttgg agctccggcg tggtctcggt cgtccaggcc ctcacggcac 18300
tgcgggaggg cgcgataccg gcgcagcgcc gcttcatcga gcccggtctc acggcagaga 18360
acggcgacgg ggtacgcgtt cccgtcgacg cggtcccgtg gcacgagggc ggcccgcgcc 18420
cccgcgtcgc gggcgtctcc gccttcgggt tcggcggcac caacgcccat ctgctggtag 18480
ccgaccgggc ccccgtccca cgcgtccggc acgtcccgcc cccggagacc gacccggtgg 18540
tcctcctcgc ctggaccgcc cacctgcccg gcgacccgga ccccgcggcg gtggcacggc 18600
tggtgcgcga cggccgtgcc ccgggaccgc ggacgttcgg gccccgctat ccggcaccgc 18660
cgttcccgga cgtccggctg ccgccaccca cggtgcggtc caccgacgcg ggccagctca 18720
tggccctgcg cgtggcgtcc ctgttcagcg ccgagcacgg cgagttgtgg gaccccgtgc 18780
gcgccaccac cggagtcttc gccgccgcgg gcggtccgcc gccgtccgcg atggaccacc 18840
tggtgcgctg ccacgccgcc gagctggacg gcctcctcga cggtcccgac cacgcggcgt 18900
tcaccgactg gctcgacgag ctcaggtcca cgaccccgcc gaccaccaag gacacgttgc 18960
cgggcatcct gcccaacatc atcccggcgc gcatcgccaa ccgccacgac ctcggcggcc 19020
ccaccatgct ggtggacacg ggcgccacca gcggactcac cgccgtgcac accgcggccc 19080
ggcaactggc ccgcggcgac gtggacatgg cactcgtcct cggtgtcagc gccacggcac 19140
ggccggagtt cgcgcacgtc atgggcatcg accccgagca catcgcggag ggcgccttcc 19200
tcctcgccct gagccgtgac tcggtcgccc gcgcccacgg cctgaacccg ctcgcccacg 19260
tccgtacggc gtggagcggc actcctcagc cctcgacgcg cttcacctgc ggagcggccg 19320
ggacagggcg gacctttctc ggcgcggacg gcgtcctcgc cgtgatccgc gccctgcacg 19380
ccgacgcgag cgacgtcgcc gtgggccctg cggacggtgc gccaggaccg gtcatcaccc 19440
tctcccccgt cgcccacagc tcgccccacc ggcagacaag gaccagccga tgagtcacct 19500
ccgcgacgcc gcggccaccg acgacccggg ggccatcgcc gcctgcgacg tccccgccga 19560
ataccgcgcc gccgtcgtcc tcgcggcgga ccagcaggct ctcgcgggaa cgcccgtcga 19620
gagccgggac ccccgcaaga cggtccacgt tcaggaggtc gccacccctg agctggacca 19680
cggcgaggtc ctcatcgcca ccatggccag ctccatcaac tacaacaccg tgtggtccgc 19740
gctgttcgaa ccggtctcca ccttccggtt cctgcgcacg ctcggccgga cctccccgga 19800
agcggcccgg cacgacctgc cctaccacgt gctcggctcc gacctttccg gagtcgtgct 19860
gcgcaccgga cccggcgtac gcgaatggaa gccgggcgac gaggtcgtcg cgcactgtct 19920
gcagccggac ctgcagacgc cgggcgggca cgacgacacg ctgctcgacc ccggacagcg 19980
ggtctggggg tacgaaacga acttcggcgg cctcgccgag ctctccctgg tcaaggcgaa 20040
ccagctgatg ccgaagcccg cccatctcac ctgggaggag gccgcctccc tgggggtcgc 20100
gctctccacc gcgtaccgtc agctggtctc ccaccacggg gcggacatga agcagggcga 20160
acgcgtcctg atctggggtg ccgcgggcgg tgtcggcgcg tacgcgaccc aactggccct 20220
caacggcggc gcgatccccg tctgcgtggt gtcctcgcag gccaaggccg acctgtgccg 20280
ccggatgggc gcggagctcg tcatcgaccg cgccgcggag gacttcacct tctgggacga 20340
gcaggacaag ccgcgcctca gcgagtggag ccgcttccgc agcgccgtcc gcaatctcgc 20400
gggggacgac ccgagcatcg tcatcgaaca cccgggccgg gacaccttcg gcgtcagcgt 20460
catgatcacc gcccgtggcg ggagcgtggt cacctgcgcc tcgaccaccg gctaccagca 20520
cagctacgac aaccggcacc tgtggatgca cgtcaagcgc atcatcgggt cacacatggc 20580
gaactaccgc gaggcctggg ccgccaacga cctcgtcgta cggggcagca tccacccggt 20640
gctctcgcgg gcctatcccc tcgacgccgt cggcgacgcc acccacgccg tggcgggcaa 20700
cagccaccac ggcaaggtcg gcgtgctgtg cctcgccgac cgtcccggca tgggagtgcg 20760
tgaccccgac ctcagggccc gcaagctcga ccggatcgac cttttccaga aaggacaaca 20820
gcggtgagtg agcccgaaca cctcgacacc gtgcggaagt tcgtcgccca ggaagtcctg 20880
ggcagggaaa cccacctgga ctcgctggcg gacgcgccgc tggcgttgta cgagcggttc 20940
gcggagacgg gcctgatgaa ctggtgggtt cccgaggagc acggcggcct cgggctcggt 21000
ctcgaagaca gcgtgcggat cgtctccgaa ctcgcctacg gggacgccgg agtggcgttc 21060
accctgttcc tgcccatcct gaccaccagc atggtcagtt ggtacggcag tgcggagctg 21120
aaggagaagc tcctcgaccc cctcgtggct catcggggct tctgcgccac gctgggcagc 21180
gagcacgagg cgggcagcga gctggccaag atctccaccg tggtgcgccg cgacggcgaa 21240
ggactcgtgc tcgacggcac caaggccttc tccaccagca ccgacttcgc gcagttcctc 21300
gtcgtcatcg cgcgctcggc ggagaacccg acccggtatc tggcggtcgc cgtggagcgg 21360
gacgcgccgg gactgcggat cgacaagcgc tgggacgtca tcggactgcg cgcctcggcg 21420
acgtaccaag tgtcgttctc cgactgccac gtgcccgccg ggaacgcgct ggacggccac 21480
ggtcttcgcc tccttgagat cgggctcaac gccagccgga tcctgatcgc cgccaccgcg 21540
ctcggcgtcg cgcgcaggat ccgcgacctg tgcatggagt acgcgaagac gaagtcgctc 21600
aagggcgctc cgctcgtcaa cgacgcggtg ttcgccgggc ggctcggcca gttcgagatg 21660
cagatcgagg tgatggcgaa ccagtgtctg gcggcggcgc gcacctacga cgcgacggcg 21720
gccaggccgg acgccgccag gacgctgctg cggcagggcg cccagaagtc ggcgctgacc 21780
gcgaagatgt tctgcgggca gaccgcctgg cagatcgcct ccaccgcgtc ggagatgttc 21840
ggcggcatcg gatacacgca cgacgtgccg atcggcaagc tgctgcggga cgtccggcac 21900
gcctcgatca tcgaaggcgg cgacgacgtc ctgcgcgatc tggtcttcca ccgcttcgtc 21960
gtgcccaccg cgaaacgcac gtagctcgct cgctgcgacc cgacagatgg cgatccgaca 22020
gatggcgatc cgacagatgg cgacccacca gctggagagc acatggcgaa tcaggtgacg 22080
atgtccgacg cgctgctcgc ttacgtccgc aaggtctcgc tgcgcgacga cgaggtgctg 22140
agccgcttgc gcgcggagac ggccgggctg ccgggtggca gcgtcctgcc ggtacaggcc 22200
gaggagggtc aactcctcga gttcctggtg ctgttgaccg gcacgcggca ggtgctcgag 22260
atcgggacgt acaccggtta cagcacgctc tgcctggccc gtggattgcc gccggggggc 22320
cgggtggtga cgtgcgacgt gacagcgaag tggccggagg tgggcaggcc gcactgggag 22380
cgtgccgggg tggccgaccg gatcgacgta cgggtcggcg acgcccggga cgtgctcgcg 22440
gggctgctcg acgaggcggg cgcggggccg ggatcgttcg acgtcgtctt catcgacgcg 22500
gacaaggcgg gctatccggc gtactacgag gcggtgttgc cgctggtgcg cggtggcggc 22560
ctgatcgtcg tcgacaacac gctgttcctc gggcgggtgg ccgacgacac ggcgcgggac 22620
ccggacacgc tcgcggtccg cgcgctcaac gcggcgctgc gcgacgacga tcgggtggat 22680
ctggcgatgc tcacgacggc cgacggcatc accttgctgc ggaagcggtg aacggaatgc 22740
cgtcggcggc ggtcagcgtc agcgtcttcg gcgtggggcg cggcgagggc tccagatgca 22800
ggcgctcgac gcggccggcc gcctcgccca gcgcggacac gcaggcacag ctcgtctccg 22860
cgaaaccggc gaaccggtag gcgacctcca tcaggcggtt gcgttccgta cgccggaagt 22920
ccgccaccag atgcgtcccg gcccgggcgg cccggtccgt gagccagtcg aggatcgtcg 22980
caccggcacc gaacgacacg acccggcagg acgtcgcgag cagcttcagg tgccacaccc 23040
gcggcgtctt ctccagcagg acgatgccga cggcgccgtg cgggccgaag cggtcgccca 23100
tggtgacgac gaggacctcg tgcgccgggt cggcgagcag cgcgcgcagt tcggcgtcgg 23160
agtagtgcac gccggtcgcg ttcatctgac tggtccgcag ggtcaactcc tcgacgcggg 23220
tgagctcttc gtggcccgcg ggcgcgatcg tcatgtacag gtccagggag cgcaggaagt 23280
cctcgtcggg accggagtac gtctccctgg cctggtcgcg cgcgaatccg gcctggtaca 23340
tcaggcgacg tcggcgcgaa tcgaccgtgg aagcggccgg gcggaactcc ggcagtgccg 23400
ggagcgcggt cacctgctcg gccgggtagc accgcacctc gggcaggtgg aacgcgacct 23460
cggcacgctc ggcgggctgg tcgtcgacga acgcgagggt ggcgggggcg aagttcaggc 23520
cttcggcgat ctcgcggacg gactgcgact tcggccccca cccgatgcgc ggcagcacga 23580
agtactcggc cacgccgagc cgttccaggt gctgccaggc gacgtcgtgg tcgttcttgc 23640
ttgccaccgc ctggaggatg ccccggccgt cgagcgtgct gatcacctcg cggatctcgt 23700
ccgtgagcac cacctcgtcg ccctcaagca cggtgccccg ccacaaggtg ttgtccaagt 23760
cccagaccag gcacttgacg atggtcgtgg tggtcatggc cgtcctctca cgccgggagc 23820
gccagcgcgt ggcgcgccag catcatccgg cacatctcgc tgctgccctc gatgatttcc 23880
atgagcttcg cgtcgcggta cgcccgctcg acgacgtggc cctcggtcgc gcccgccgac 23940
gcgagcacct gcgcggcggt ggcggcgccc gcggcggcac gttccgccgc gacgtgcttg 24000
gccaggaccg tcgcggtcac cgcgtcgggc gagccctcgt cccagcggtc gctcgcgtac 24060
tcgcacacgc gcgtcgcgac ctgttcggcg gtccacaggt cggcgaggtg cccggcgacg 24120
agttgatggt cggcgagcgg tcggccgaat tgctcccggg tccgagcatg ggccgtcgcg 24180
gcgactcggc aggcccgcag aatcccgacg cagccccagg cgaccgactt gcgcccgtac 24240
gcgagcgccg ccgcgacgag catcggcagc gacgccccgg acccggccag gaccgcgccc 24300
accggcaccc gcacaccgtc gaggtgcagg tcggcgtggc ccgcggcacg gcatcccgac 24360
ggattcggga cacgctcgac gcgtacgccc gcggtgtcgg ccggcacgac caccgccgcg 24420
ccggaaccgt cctcctggag gccgaagacg accaggtggt ccgcgtacgc ggccgcggtg 24480
gtccacacct tgtggccgtc gacgaccgcg gtgtccccct cgatccgcac ccgcgtgcgc 24540
atcgccgaca gatcgctgcc cgcctggcgc tcgctgaagc cgaccgccgc gagcttcccg 24600
ctggtcagct ccttcaggta cgtcgaccgc tggccggtgt cgccgagccg ccgcacggtc 24660
cacgcggcca tcccctgcga cgtcatgacg ctgcgcagcg aactgcagag gctgccgacg 24720
tgcgcggtga actggccgtt ctcgcggctg ccgaggccca gaccgccgtg ctcgacggcg 24780
gcctccgcgc agagcaggcc gtcggcgccg aggcggacga gcaggtcgcg gggcagctcg 24840
cccgacgtgt cccagcctgc ggcccggtca ccgacgaggc cggtcagcag cgcgtcgcgc 24900
tcaggcaccc tcgccccgca gccggtggac gagttcgacc atggacacga cggtccggaa 24960
gttcaccaac tgaaggtccg ggcccccgat ctccacgccg aacgtcttct ccaggaacac 25020
caccaactcc agcgcgaaca gcgacgacag gccgccctcc gcgaacaggt cgcgctccac 25080
cgaccagtcc gacctggtct tcgtctccag gaacgcgacc agctcacgcg cgacgggatc 25140
gtccttgacg gggactgtca ccggaacacc tcttcgtagt cgtagaagcc acgcccggtc 25200
ttccggccgt ggtgcccgtc gcggaccttg ccgagcagca ggtcgcaggg gcggctgcgg 25260
tcgtcgccgg tgcgcttgtg caacacccac agcgcgtcga cgaggttgtc gatgccgatc 25320
aggtccgcgg tgcgcagcgg ccctgtcgga tggccgaggc agcccgtcat gagcgcgtcg 25380
acgtcctcgg tggaggcggt gccctcctgc acgatccgcg ccgcgtcgtt gatcatcgga 25440
tggagcaacc ggctcgtgac gaagccgggc gcgtcccgga cgacgatcgg cttgcggccg 25500
agcaccgcga ggaggtccgc gacggcggcc atggccggtt cgccgctgcg gggcccgcgg 25560
atcacctcga ccgtggggat cacgtacgac gggttcatga agtgcgtgcc gagcaggttc 25620
tccggccgtg ccacggcgtc ggccagctcg tcgaccggga tcgacgacgt gttggtgatg 25680
atcggggtgc cgggcggcgc cgccgccgag accgtggcga gcacgtccgc cttgaccacg 25740
gcgtcctcga cgacggcttc gatcaccgcg tcggccatgc cgatcgcggg cagcaccgac 25800
gtcgtcgtct caaggacgcc ggggtcggcc tcggcgggcc cggccacgag ctgtgccatc 25860
cgcagctcgg cggctatccg cgtccgcgcc gccacgagga tcgcgtcgga ggtgtcgacg 25920
agcgtcacgt ggacgccgtg gcgcagcgcg agcgtggtga tgccggtgcc catcactccc 25980
gcgccgagca cgaggatccg gtgcgccatg ccctctcctt cccctggcct caccacggca 26040
gcgagtacgg gtcgagtacg tcctccggcg ccgctccgat cgcggccttt cggccgagac 26100
cgagctcgtc cgcgaagccg agcagcacgt cgaacgcgat gtggtcggcg aacgcgctgc 26160
cggtggagtc gaggacgctc aggctgtcga cgtgcgccgt cgcgctgctc ggcgccgcgc 26220
acaagctcgc gagggacggg ccaaggtcac ggtccggcag ttgctggaac tcgccttccg 26280
cgcgggcctg tccggggtgg tcgacgcaga tgaacgcgtc gtccagcaga ggtctcggca 26340
actcggtctt gcccggctcg tcggcgcccg tcgcgttcac gtgcaggtgc ggcagtcgcg 26400
gcccggcagg cagcacgggg ccttcgcccg cgggcaccga ggtgacggtg ctcaggacgt 26460
ccgcggcggc gaccgccgcc gcgggaccgg tgacatcaac cgtgaggccg aggaacgcga 26520
cgcggcccgc gaaggactcc gcgtggtccg ggtcggtgtc gctgaccagg atccgctcga 26580
tcggcaggac cctgctgagc gcgtgcgcct gggtcaccgc ctgcgcgccc gcgccgatca 26640
gtgcgagcgt ggcgctgtcg ggcctggcga ggagtcggct cgcgatcgcc gagaccgcgc 26700
cggtccgcat cgcggtgatc acggccgcgt cggcgaacgc gatcaggctc ccgctgtcgt 26760
cgtccaggcg cgacaccgta ccgacgaccg tcggcagccg gaatcgccgg tagttgtgcg 26820
gactgtacga gatcgtcttc atggtcacgg cgacaccggg cacccggtac ggcatgaact 26880
cgatgacgcc gggcacttcg ccgccgcggg cgaatccact gcgtggtggc gcctcggcga 26940
gctctccacg gcccagtgcg gcgaagccgt tgtgcaggtc gtcgatcagc cggtccatga 27000
tcgcgtcgcg gccgaccacg gagagaatct gcttgatgtc gcgctgccgc aggatcttgg 27060
tctgcatgtg tcacctccct ttcttggtcg gggctgtgcg cagctcccgg tcgatgaggt 27120
cgaagatctc gtccgcggtc gcgtcctcgg acaacacgtc cgccggtacg gccgggcggc 27180
ccacccgctg ccagcgctcg aacagggcgc cgatgcgggg cccgatcgag tcgttcctgc 27240
gatcacccgg gtcgacgtcc gcgaccagtt cctcaaggcg gtcgagttgc gcgagtaccg 27300
cggccgccgg atcgtccggg gacaggagtt caccgatgcg gcctgcgagc gcgcgcggcg 27360
tcggatagtc gaagacgagc gtggcggaga gccgcagacc ggtcgcttcg ttgaggccat 27420
tgcgcagttg caccgcgatg agcgagtcga cgccgagctg ccggaacgcc gcgtcctccg 27480
ggacgtcctc cggtcccgcg tgccccagca gggctgccgc cttctgccgt acgagcgtga 27540
gcaggtcggt gtggcgcgcg acctcgttgc gggcgccccg ccgggccacc ggtttgcggc 27600
gaccgcgcaa cagcggtatg tccgaaggaa gttcacccgc cacggcgacg acactgcccg 27660
ttccggcatg aacggcggcg tcgtacatgc gcatgccctg ctcggcggtg agtgccctcg 27720
ccccgccttg acgcatgcgg cgccggtcgg cgtcggtcag ctcgccggtc agaccgctcg 27780
cctggtccca cagcccccac gcgatcgaaa ggcctggcag cccctgcgta cggcggtgtt 27840
cggcgagtgc gtcgaggaac gcgttcgccg ccgcgtagtt gccctgacct ggcgtgccca 27900
acacaccggc agcggacgag tagaggacga atgcggcgag gtcggtggcg tgggtgtggg 27960
tgtggtggtg gaggtgccag gcggcgtcgg ctttgggttg gaggacggtg tcgatgcgtt 28020
ggggtgtgag gttgtcgagg agggcgtcgt cgagggcggc ggcggtgtgg aagacgccgg 28080
tgaggggttc gggtatctgg gcgagggcgg tggcgagttg ggtggggtcg ctgacgtcgc 28140
agggcaggtg ggtgccgggg gtggtgtcgg gcgggggtgt gcgggagagg aggtaggtgt 28200
gggggtggtt gaggtggcgg gcgaggattc cggcgagggt gccggagccg ccggtgatga 28260
tgacggcgcc ctcggggtcg agcggccgcg ggaccgtcag caccagcttg ccgacgtgtt 28320
cgcctcggct catggtcgcc agcgcgtcgc gggcctgacg tatgtcgtga accatcaccg 28380
gtagggggtg cagtgtgccg ttcgcgaaca ggtcgaggag ttgggtgatg atctgctgga 28440
gtcggtcggg tcccgcgtcc atgaggtcga agggctgctg ggcgtggtgg cggatgtcgg 28500
tcttgcccat ttcgatgaac cggccgccgg gtgcgaggag tgcggtggag gtgtcgagga 28560
gttcgccggt gagggagttg agtacgacgt cgaccggggg gaaggtgtcg gcgaacgcgg 28620
tgctgcggga gtcggcgatg tgggtgggtg ccaggtccac caggtgctgt ttgggggtgc 28680
tggcggtggc gtacacgtcc gcgcccaggt ggcgggcgat ctggacggcg gccgcgccga 28740
ctccggtggc cgcagcgtgg atgaggacct gctcgccggg gcgcagcttg gccaggtcga 28800
ccaggccgta ccaggcggtc gcgaacaccg tcaccaccga cgccgcctgc gggaacgtcc 28860
agtcgtccgg catccggccc agcatgcggt ggtcggcgat gaccgtgggg ccgaaaccgg 28920
tccccacgag gccgaagacg cggtcgcccg ctgtcaggcc ggaaacgtct gcgccggtct 28980
ccaggacgac gcccgcagcc tcgccgccga gaacgccccg gccgggatag gtgccgagcg 29040
cgatcagcac gtcacggaag ttgagacccg ccgcacgtac gccgatccgg acctcggtcg 29100
gcgccaacgg gcgccagggt tccgccgaat cggccgcggt gaggccgtcg agagtgcccg 29160
tgggcgccgg tcggatcaac cacgtatcgc tctccggcac gatgagcggt tccggcacac 29220
gggtgaggcg ggccgcctcg aaccggccgc ggcgcaggcg aagacgtggc tcgtccagtg 29280
cgacagcgat gcgctgctgc tcgggttcga gtgtgactcc gggcgcggtc tcgacgtgga 29340
cgaaccggcc gggttgctcg gcctgggcgg cgcgcaggag cccggcggcc gcggcggtgg 29400
cgaggccctc ggtggtgtgc acgagcaggg tctggtcggt tccggtcagg gccgccagca 29460
agtgggccgt cagcgcgcgt gtctcggccg tcgggtcatc gtcggcagcg gcgtgcagcg 29520
tgatgacgtc cacgtcgccc gtggggacgt ccacgggtac ggcgacctcg gtccaggcca 29580
ggcgcatcag gccggtgtcc gcgggcgggg agagcgggcg ggtgcggatc gtccggatct 29640
cggcgaccag ttggccggtg gagtcggcgg cgcgcaggct cagttcgtcc ccgtcccggg 29700
tgatcacgac tcggagcgtg gtgggaccgg cgctgacgaa ccgggccccc gtccacgcga 29760
acggcaggcc gggggcactg tcgtccggca cggtgaaggc gacggcttgc agggccgcgt 29820
cgagcagggc ggggtgcagg gcatagcggg tcgcctcggc ggcttgctcg tcggagaggg 29880
tgacgtccgc gtagacggtg tcgccatctt gtcgggcggc gcgcagtccc tggaacgccg 29940
gtccatagcc gtaaccggcg tcagcgagct cgtcgtagaa ggtggtgacg tcgacaggtt 30000
gtgcgttggg cgggggccac tggaggaacg tgtcggtgct ggaatcggga tgggtgggat 30060
cagggccgat gttggtggtg agtgtgccgg tggcgtggcg ggtccaggtg tcggttcctt 30120
cggggcgtgc gtggacgctc actgggcggc gtccggtggt gtcgggctga tcgacggtga 30180
cggtgagatc ggcagcaccg gtcacgggca gggtgagtgg cgtctcgatg accagctcgt 30240
cgatggtgtc gcagccgacc tcgtcaccgg cccgcaccac gagttcgagc aacgccgtgc 30300
ccggcagcaa caccgtgtcc tgcaccgtgt gatcggccag ccagggatgg gtacgcagag 30360
agatccggcc cgtgagcagc acgccgtcgc tgcccggcag caccgccgca ctcgacagga 30420
acggatgccc gatccccgcg ccgccgaccg gggcgggctg cagccagtac cgcttgtggt 30480
cgaaggggta ggtgggcagg tccaacaggc ggtgctgggc gggctcgatc agggtggtcc 30540
agtcgacgtc cgcgccctgg gtccaggcct gtgcgagggc ggtcaggaac cggtcccagc 30600
cgccgtcatc ggtacgcagg gaagcgaccg tgcgctcctg gtccagggcg ggcagcagca 30660
ccgggtgggc gctgcactcg atgaacagcg aaccgtccag ctcactgacc gccgtgtcca 30720
tcgccaccgg ctgacgcagg ttgcggtacc agtagtcgtc gccgaccgct tcggtcaccc 30780
agccgctgtc caccgtcgac caccaggaga tgtcaggtgc gctgctggtg atccccccta 30840
agacgtcggc cagttcgtcc tggatcgctt ccacgtgcgg ggtatgcgag gcgtaatcca 30900
ccgcgatccg gcgcacccgc acacccgcag cctcataccg ggccagcacc cgctccaccg 30960
ccgccggatc gcccgcgacc acggtggatt ccggaccgtt gcgcgccgcg atccacaccc 31020
cctccatcac ctcaacggca ctggcgggca aggcgattga cgccatcgcc ccgtgcccgg 31080
ccagccgcgc ggcaatggtc tggctgcgca aggccacgac ccgcgcggcg tcctccagac 31140
tcaacgctcc cgccacacat gccgcggcga tctccccctg cgaatgcccc accaccgcat 31200
ccgggacgac accatgcgcc tgccacagtg cggccagact caccgccacc gcccacgacg 31260
cgggctgcaa cacctccacc cgatcagcca ccaccgcctc acccaacaca tccagcacat 31320
cccaccccgt gtacggctcc agcgccgccg cacactcccg catccgcgcc gcgaacacct 31380
ccgagacgcc catcaactcc cggcccatcc ccacccactg cgagccctgc cccggaaaca 31440
cgaacaccgt ccgcgccccc tccacagcca ccccggcaac cgtgctctcc cccagcaaca 31500
ccgcccgacg gtcgaacacc gcacgcccac gcaccagacc atccgccacc gcgcccaggt 31560
ccgccccacc ccgcacgtac gcacccagcc gctccacctg gaccgccaga ctcgactccg 31620
tacgcgccga caccggcaac ggcaccaacc ccccacccga ggaagcctcc gcacccgaag 31680
acggctcagg cgcaccctcc agcaccacat gcgcgttcgt gccactgacc ccgaacgacg 31740
acacacccgc gcgcggcacc cggccggact ccggccacgg cctcgcctcg gtgaccacct 31800
caacagctcc ggccgtccag tccacgtgtg acgacggctc atccacatgc aacgtccgcg 31860
gcaccacccc acgccgcatc gccatcacca tcttgatgac accagcaaca cccgccgccg 31920
cctgcgcatg accgatgttc gacttcaacg aacccaacaa caacggaact tcacgaccct 31980
gcccatacgt cgccagaacc gcctgcgcct cgatcggatc ccccagaacc gtccccgtcc 32040
cgtgcgcctc caccacatcc acatccgccg cgccgagccc cgcgttcgcc agggcctgcc 32100
ggatcacgcg ctgctgcgac gggccgttcg gcgcggagag gccgttggac gcgccgtcct 32160
ggttcaccgc agaaccacgg acgaccgcga gaacggtgtg accgttgcgc tccgcatcgg 32220
aaagccgttc cacgaccagg acaccggcgc cttccgccca tccggtgccg ttcgcggcgt 32280
ccgcgaacgc gcggcagcgg ccgtcgggag agagcccgcc ctgctgttcg aactcgacga 32340
atccgtccgg gttcgccatg acggtgacac cgccgaccag cgcgagcgag cactcaccgt 32400
ggcgcagggc gtgccccgcc tggtgcagcg cgacgagcga tgacgagcac gccgtgtcga 32460
cggtgaacgc cgggccctgg agcccgtaga agtacgagat ccggccggtg aggacgctgg 32520
gctgcacgcc gatcgagccg aacccgccca ggtcggcgcc gacgccgtac ccgtaggaga 32580
aggcccccat gaacacgccg gtgtcgcttc cgcgcagcgt gcccggcacg atgcccgcgt 32640
tctcgaacgc ctcccacgtc gtctccagca ggatccgctg ctgcgggtcc atggccagcg 32700
cctcgcgcgg actgatcccg aagaacgcgg cgtcgaagtc ggcggcgtcg gagaggaaac 32760
cgccgcgatc cgcgtccggt ccgccggtga ggcccgaagg gtcccagccg cggtcgaccg 32820
ggaagccggt gaccgcgtcg ccgccactgt ccagcatctg ccacaggtca cccggggagg 32880
cgacgccgcc gggcaggcgg caggccatgc cgacgatcgc gaggggctcg tcgcgggacg 32940
cggcggccgc cggaaccgcg gccgggactg cgccgccgac cagcgcctcg tccagccgtg 33000
acgcgatggc cctcggtgtc ggatggtcga aggcgagcgt ggcgggcagt cggacgccgg 33060
tcgccgcggc gagccggttc cgcagctcga cggcggtcaa cgagtcgaca ccaaggtcct 33120
tgaacgccgc gtccgccggg acgcccgcgg cgtccacgtg gcccagcacc gccgccgcgc 33180
agtcgcggac cagggtgagc agcgcggcat cccggtcggc gccggtcatg gcgccgagcc 33240
gctcggcgag cgggacagtg gtggcggccg ccccgcgcgg cacggagcgg cgcaagctcg 33300
cgaggagggg ggacgtctgt tcgcgcaggt ccatgatggc cgccacggcg aacgcggcat 33360
cggaaccggc cgcggtctcc aacaggcgta gggccaggcc tgcttgcatg gggcggaaac 33420
caccgcggcg tacgcgggtc cggttcgtgt cgctcatgcc gccggtgagt ccgctgtcgt 33480
cggcccacag tccccaggcc agtgacagcg cgggcagccc ctcggcacgg cgctgcgcgg 33540
cgagtccgtc gaggaacccg ttcgccgccg cgtagttggc ctggccacgg ccgccgagga 33600
tgcccgcgac ggacgagtag aggacgaacg cgcgcaggtc cgcaccgcga gtcagctcgt 33660
gcagatgcca ggcgccgtcg gccttggggc gcagcgtggt ggcgagccgc tccggcgtga 33720
gcgccgcgac cacaccgtca tcgagcgccg ccgccgtgtg gaagaccgcc gtgagcggcc 33780
gatccacggc ggcgagcgcg gcggcgagct ggtccctgtc ggagacgtca cagcggacgt 33840
ggacgccggg tgtgtccgcc ggcggctcgc tgcgcgacag cagcaacaga tggcgggcgc 33900
cgtgctcggc gacgagccgc cgggcgagaa gaccggccag cacgcccgag ccgccggtga 33960
tgaccaccgt gccgtccggg tcgagcaacg gctcgtacgg cggcgtggcg accgcccggg 34020
tgagccgggg cgcctcgtat cggccgtcgg tgacgcgaac gtacggctcg gccagtgtcg 34080
tggccgcggc catcgcctcg acggaggtgt cggcgccggt ctccacgagc acgaatcggc 34140
ccggatgctc ggcctgcgcg gaccggacga gtcctgcgac cgctcccccg gtcggtcccg 34200
cgtcgacgcg gacgacgata gtggtctccg cgaggctgtc gtcggcgatc acccggtgca 34260
actcggcgag cacgagctcg gagagccggt aggtctcgtc gagcacgtcc gcgcccgggt 34320
ccgggactgc tgagacgact tggaccgcgt ccgcgggacc gggggtggag gcgggagtgg 34380
gcagttcggt ccaggagagg tcgtacaggg agttacggac ggcggcgtcg gtgtcggcgt 34440
cggtgctgac gttcaccggc cgcgcggtca actcggagac ggtcaccaca gggtggcctg 34500
ccgggtccgc cgcgtgcacg gccacgccat gggggcccgg ggtgatcgcg acacgcagcg 34560
tggtggcgcc ggtcgtgtgg aaccgtacgc cgttccacga gaacggcagc ttcacctccg 34620
acgccgagtc cgaatcctgc cccgtgagcg gcggcaggca ggtgacgtgc agcgccgcgt 34680
cgagcagggc cgggtgtacg ccgtagcggg acgtgtcgtc cgcctgttcc gcggcgatct 34740
ccacctcggc gtacaaggtt tcgcctgcgc gccaagccgc gcgcaggccg cggaatgccg 34800
ggccgtagag gtagccggtc tcagcgagcc gctcgtagaa gccggtgacg tcgacgggtt 34860
gtgccccggg cggcggccac gcggacgagg gggccgccac ggtgtttccg gcgcggccga 34920
gtgtgccggt ggcgtggcgg gtccaggtgt cggttccttc ggggcgtgcg tggacgctca 34980
ccgggcggca tccggtgtcg tcgggctggt cgacagtgac ggtgagatcg acggcaccgg 35040
tgacgggcag tacgagcggg gtctcgatga ccagttcgtc aatggtgtcg cagccgacct 35100
cgtcaccggc ccgcaccaca agttcgagga acgccgtgcc cggcagcaac accatgtcct 35160
gcacggcgtg atcggccagc cacggatgcg tggccaggga cagcttgccc gtgagtagta 35220
cgccgtcgct gcccggcagc accgccgcac tcgacaggaa cggatgcccg atccccgcgc 35280
caccctccgg ggcaggcaac agccagtacc gcttgtggtc gaaggggtag gtcggcagat 35340
ccaacaaccg gtgcggggcg ggctcgacga ggatggtcca gtcgacgtcc gcgccctggg 35400
tccaggcctc ggcgagcgcg gtcaggaacc gctcccagcc accgtcatcg gtacgcaggg 35460
aagcgaccgt acgctcctgg tccaaggcgg gcagcagcac cggatgggca ctgcactcga 35520
tgaacagcga accgtccagc tcgccgatcg ccgtgtccat cgccaccggc tgacgcaggt 35580
tgcggtacca gtagtcgtca tcgaccggtt cggtcaccca gtcgctgtcg accgtcgacc 35640
accaagggat tgtggggact tgggccgtca ccccttccag gacctcggcc aactcgtcct 35700
ggatcgcttc cacgtgcggg gtgtgcgagg cgtaatccac cgcgatccgg cgcacccgca 35760
caccctcggc ctcgtagcgg gccagcacct gctccaccgc cgccggatcg cccgcgatca 35820
cagtcgagga ggggccgttg cgggccgcga cccacactcc ctccatcacc tcaacctcgg 35880
cagagggtat ggcaattgac gccatcgccc cacgaccggc cagccgcgcg gcgatggtct 35940
ggctgcgcaa ggccacgatt cgcgcagcgt cctccagact caaggccccc gccacactcg 36000
ccgcggcgat ctccccctgc gaatgcccga tcaccgcatc cggagtgccc ccgtgggcct 36060
gccacagtgc ggccaggctc accgccaccg cccacgacgc gggctgcaac acctccaccc 36120
gatcagccac caccgcctcg cccagcacat ccagcaaatc ccagccggta tgcggctcca 36180
gcgccgccgc acactcccgc atccgcgccg cgaacacctc cgaggcgccc atcaactccc 36240
ggcccatgcc cacccattgc gagccctgcc ccgggaacac gaacaccgtc cgcagctcgc 36300
cctcagccac cccggcaacc gtgctctccc ccagcaacac cgcccgatgg ccgaagacca 36360
cccgctcacg gaccaggcca tccgccaccg cgctgaggtc cgccccactc cgcacgtacg 36420
cacccagccg ctccacctgg accgccaggc tcgactccgt acgcgccgac accggcaacg 36480
gcaccagacc cgacgacccc ccgctacgaa ccgacgactc cgcaacctcc tccaaaatca 36540
catgcgcatt cgtgccactc accccgaacg cggacacacc ggcccggcgc gggcggtccg 36600
actccggcca cggcctcgcc tccgtgagca gctcaaccgc cccggtcgtc cagtccacgt 36660
gtgacgacgg ctcatccaca tgcaacgtcc gcggcaccac cccacgccgc atcgccatca 36720
ccatcttgat gacaccggca acacccgccg ccgcctgcgc atgaccgatg ttcgacttca 36780
acgaacccaa caacaacgga acttcacgac cctgcccata cgtcgccaga accgcctgcg 36840
cctcgatcgg atcgccgagg accgttcccg tcccgtgcgc ctccaccacg tcgacgtcgg 36900
ctggagcgag tcccgcactt ccgagtgcct gacggatcac ccgttgctgg gccgggccgt 36960
tcggtgcgga gatgccgttg gacgcgccgt cctggttcac cgccgagccg cgtacgaccg 37020
cgagaacggt gtgaccgttg cgctccgcgt cggacagccg ttccacgacc aggacaccgg 37080
cgccctcggc gaacccggtg ccgtccgccg cgtcggcgaa cgccttgcac cgcccgtccg 37140
gggccacgcc gccctgccgg gagaactcca cgaagctctg cggcgacgcc atcaccgtga 37200
caccgccgac gagcgcgagg gagcactcgc ccgcgcgcag tgcctgaccg gcctggtgca 37260
gggcgaccag ggacgacgag cacgccgtgt cgacggtgac ggcggggcct tcgagtccga 37320
agaagtatga gaggcggccc gcaaggaccg cgggctgtgt gctgtaggcg ccgaagccac 37380
ccaggtccgc accggcgccg tagccgtagt agaagccgcc gacgaacact cctgtgtcgg 37440
tgccgcgcag cacgtccgcc ttgatacccg cgcgttcgat ggcctcccag gcgatctcga 37500
gaaggatccg ctgctgcggg tcgagcgcgg tggcctcccg cgggctgatg ccgaagaacg 37560
cggcgtcgaa gtcggcggcg cccatgagcg cacccgccct cgacgtcgcg gactcggcgg 37620
cggcgtgtag tgcggccacg tcccagcccc ggtcggtggg gaagtcgccg accgcgtcac 37680
cgccgtcctc gacgagctcc cacagctctt ccggggacgt gatgccgccg ggcaggcggc 37740
acgccatccc gacgacggcg agcggctcgt tcgcggcggc gcgcagcgcg gtgttctccc 37800
tgcgcagttt cgcgttgtcc ttgaccgacg tccgcagcgc gtcgatcagg tcgtttccag 37860
ccatcgcctc atcccttcag cacgtgcgcg atgagcgcgt cggcgtccat gtcgtcgatc 37920
aattcgtcgt cgggcgatgc gacttccgag tcggttgccg gagcgctcgc gggtattcgt 37980
gccggtggct caccgtcggc cggggtcccg ttgccgtccg ccggggccag cagcgtcagc 38040
aggtgtcggc tgagcgttcc ggccgccgga tggtcgaaga cgagcgtggc gggcagcggg 38100
atgccgaggg cctcggcgag gcggtcgcgc aggccgagcg cggtgagcga gtcgaccccg 38160
aggtccttga acgccgcggt ggccgtgacc gcccgcgcgt cggcgtggcc gagcagcgtg 38220
gccgcggtgt cacggacgac gtcgagcaga acctgctcct gttcctttcg cgacaggtcc 38280
ggcaggcgtt ccagcaggga gccgccgtcg gcggcggacc gccgggcggg acgccggacc 38340
ggccgccaca gcggcgaagg gtcgccgggc cggggcgggg tggttgccac gaccacggct 38400
tccccggtgg cgcacgccgc gtcgagcagc tcggtctgcc ggtcctcggc cgcggtgaac 38460
gccacggcgg gcagcccctc cgcccgacgc agctcggcca gggcttccca cggccccgcc 38520
gcctcaccgg gcggaaccac gagcacgaac gcggtcagcg gaaggtcgcg ggtcagccgg 38580
tgcagctccc aggccgattc ggccgcgccg tgcgcgtgga cgaccgcggt caccggggtc 38640
tggggcagct tgcccggctc gtggtggatc acctcggctc cgtgttcgct cagccgccga 38700
gcgagcccct ccgaaccgcc gtcgaggagc acgacgtcgc cgtacggcac cggagtcgtg 38760
gttgtcaggg ccggggtgag gcgtggcgct tcgaggcgtc ccccggtcag tcgcaggtgt 38820
ggctcgtcga gtcgggcgag ggcggcggca cggcggggcg tcaccgtgtc tccggtctgc 38880
acgagcacga gccgtcccgg ttcgacggcg tcgagcaggg cggcgacggc accggcgacg 38940
ggtccggcct cggcggacac gaccagcgtg gcgtcggcgg tcctcgggtc gtcaagagcg 39000
gcacggactt cggcgggatc ggatgccctc atgaggacga cgtcgggcga ggtggcgtcg 39060
ggcgaggcca catcgggcaa ggtggcatcg gacctcgcgc cgtcgcccag gtcggcgtac 39120
cggacggctg tggtgccggg tgccgcggga gcccgtacgc cggtccacgt acgccggtac 39180
agccggacgt ctccgccgcg atccgcctcg gcgaggggcc gggtgacgaa cgacccgatc 39240
tccgcgacca gttgtcccag ttcgtcggcg atgtggacgc gggcaccgcc gtctcccggc 39300
acgaacgtga cacgtgcctt cgcggcgccg ctcgagtgga cgcggacccc ggtgaacgcg 39360
aacggcagtc gtacccccgc gttctcggag cccgcggaga ggctgcccgc ctggagcgcg 39420
gtgacgagca gtgccgggtg cagcgtatag cgggcggcgt ccctggcgag ggcgccgtcg 39480
atggccacct cggcgtagac ggtgtcgccg tggctccacg cggcggacat gccgcggaac 39540
tcggggccga actcgtaccc gcctgcgtcg agtcgccggt agaactccgc gatgtcgatc 39600
cgttccgcac gcgcgggggg ccagggccct tcggcggtcg ccgactcggt cgtggcgatg 39660
gctgcgtagc ccgaggcgtg gcgggtccat gtgctcccac cgtcctccct ggcgtggatc 39720
cgcacggcgc ggcgtccggc gtcgtcggcc gccgcgacgg tcacacgtac ctggacggcg 39780
ccggtcgcgg gcagcgcgag cggtgtctcg atgaccagtt cgtcgagcag gtcgcagccc 39840
gcttcgtcgg cgccgcgccc ggccagctcc acgaacacgg gcccgggcag cagcacttcg 39900
ccgtcgacgg tgtgcccggc gagccacggg tgggtggcga gcgagagccg cccggtgagc 39960
agcgcctcgt cggagtcggg cagcgccacg gacgcggcga gcagcgggtg gtcgacggcg 40020
tcgagcccga ggccggaagc gtccgtgccg gcggagggct cgatccagta gcgctcgtgg 40080
tggaacgcgt acgtgggcag gtcgtgtgcc gtccccgtcg cggcgccgtc cgccgtcctc 40140
gcggtgtcgt gtgccgcccc cgtcgcggcg acgaccgtgg gccagtcgac ggccactccg 40200
acggtgtgcg ccttggccag cgagtcgagc agccggtcgg ctcccccgcc gcggcgcagc 40260
gtgccgacgg tcgtgccgtt gatcgcgggc agcagcaccg ggtgcgcgct gacctcgatg 40320
aacacggtgt cgcccggctc acgggcggcg gccacggccg ccgcgaaacc gacggggttg 40380
cgcatgttgc ggaaccagta ctcgtcgtcg agcggcgcgt cgatccagcg ctcgtcggcg 40440
gtggagaacc acgggatctc gggggcgcgc gaggtggtgg ccgcgacgat ccgctggagc 40500
tcgtcgtaca gcgggtcgac gaacggggtg tgggtcgggc agtcgacgac gagccgcgtc 40560
acccagacgc cgcgggtctc gtagtcggcg atcagcgtct cgacggcgtc cggccgtccg 40620
gacacgatcg tggtggcggt gccgttgcgg cccgcgaccc acacgccgtc gatgcgtgcg 40680
gcggccgcct cgacgtcggc ggccgcgaac gcgatcgaac ccatcgcgcc gcgccctgcg 40740
agctcgcgca ccagcagtgc gctgcgcagc gccacgaggc gggcgccgtc ctccaacgag 40800
atcgccccgg cgacgcaggc cgcggcgatc tcgccctggg agtgcccgat gacggcgtcc 40860
ggacgtacgc ccgcggcctc ccacacggcg gccagcgaca ccatgaccgc ccagcacacg 40920
gggtgcacga cgtcgacgcg gctcttcacc gcggggtcgt cgagcatggc gatcaggtcc 40980
cgcccggtgt gctcggccag ggcgtccgcg cattggcgca tcctggccgc gaacaccggg 41040
gactccgcca tcagtttgcg gcccatgccg agccactgcg agccctgtcc ggggaagacg 41100
aagacggtac gcggcgcggt gagcgccgtg cccgtgacga cgccgtcgcc gaggagtacg 41160
gcgcggtgcg ggaagtccgt acgcgtggcg agcagcgccg cggcgacggc acgcgggtcg 41220
tcgccggggt gggtggcgag gtgctcgcgg agccgttgga cctgaccgtc gacggcctcg 41280
gaggtccgcg ccgagacggg cagtggtgtg agctccgtgg cgaacagcga tgcgctgggc 41340
tccaccaccg gtgaatccaa ggccggtggc tctggagccg cgtgggcttc gaggatgacg 41400
tgggcgttgg tgccactgac tccgaaggag gacacggcgg cgcggcgagg gcctgtggtg 41460
gcgggccagg gccgggcgtc cgtgaggagt tcaacaccgc ccgccgtcca gtcgacgtgt 41520
gaggagggtg tgtccacata cagggtgcgc ggcagcgaac cgtgccgcat cgccaggacc 41580
atcttgatga tgcccgcgac ccctgcggcg gcctgggtgt ggccgatgtt ggacttcagc 41640
gaacccaaca ggagcggcgt cgcccggtcc tgtccgtacg tcgcgaggag cgcggtcgcc 41700
tcgatggggt cgccgaggcg ggtgccggtg ccgtgcgcct cgaccgcgtc cacatccgag 41760
ggccggaggc ccgcgttcgc gagggcctgg cggatgacac gttcctggga gggcccgttg 41820
ggcgcggaga ggccgttgga ggcgccgtcc tggttgacgg cggagccccg tacgaccgcg 41880
agaatacggt ggccgcggcg ctcggcgtcg gagagccgct ccacgaccag gaccccggaa 41940
ccctcggcga aagcggtacc gtccgccgcc tccgcgaacg ccttgcagcg cccgtccggc 42000
gcgagtccgc gctgctggga gaactcgacg aacccaccgg gcgacgccat caccgtgacg 42060
ccgccgacca gcgcgagcga gcattcaccg gtacgcagcg actgccctgc ctgatgcagc 42120
gcgaccagcg acgacgaaca cgccgtgtcg accgtgaccg ccgggccctc cagaccgtag 42180
aagtacgaaa gacggcccga gagcacgctc gtctgcgtgc cggtggcgcc gaatccgccg 42240
aggtcggtgc cgagtccgta tccgtcggag aacgcgccca tgaacacgcc ggtgtcgctc 42300
ccgcggagcg tgccgggcac gatgcccgcc tgttcgagcg cctcccagga tgtctccagg 42360
acgacacgtt gctgcgggtc catcgcgatg gcctcacgcg gactgatgcc gaagaaaccg 42420
gcgtcgaagt cacccgcccc ggacaggaat ccaccgtgcc ggaccgtcga cgtacccgga 42480
tgctccggat cgggatcgta gagcgcctcc acatcccagc cacggtccgc ggggaacgcc 42540
gtgatgccgt caccgcccga ctccagcaac cgccacaggt cctcaggaga tgccacccca 42600
cccggcaacc ggcacgccat gcccacgatc gccagcggct cgtcatgccc gccgaccgcg 42660
gtcgtggcgc gggtccgcgc cggtgcccgg ccggtcagcg cggcggtcag cttcgccgcg 42720
acggcttgtg gcgtcgggaa gtcgaagacc gcggtggccg ggagccgtac gcccgtcgcc 42780
tcggtgaacg cgttgcgcaa tcggaccgcc gtgagggagt cgacgccgag ttccttgaac 42840
gtcgcggtcg cctcgatccg cgcgggtcct tcgtggccga gcacggccgc cgcgcactcc 42900
cggacgacgg cgagcgccgc cttctccgca tcggccgcgg tcagccccgc gatccggtcg 42960
gcgagagcgg aggcaccggc cgcgcggcgc cgcgggcccc ggtgcggcgc cctgaacagg 43020
gccgaactgc cgaggcccgc cgggtctgcg gcgacgagcg ccgcgtccgg ggaccgcagc 43080
gccgcgtcga gcagcgcgag accgcgttcg gtgctcagcg ccgtgacgcc gtcccggcgc 43140
atgcggtccc cggccccggc cgtcaggccg ctctccggct cccagagccc ccaggccacg 43200
gacagcgcgg gcagtccggt ggccctgcgc tgttcggcca gttcgtcgag gaacgcgttc 43260
gcggcggcgt agttgccctg tccggggctg ccgagtactc cggcggccga ggagtagagc 43320
acgaacgccg cgaggtcctg gtccttcgtg agttcgtgca ggtgccaggc tccgtcggcc 43380
ttcggacgca gcacggtgtc cagccgctcg ggggtgagtg cggtgaggac tccgtcgtcg 43440
atgacggccg cggtgtgcac gacggccgtg agggggtgcg cggggtcgat ccccgccagt 43500
gccgaggcga gttcgtcccg gtcggcgacg tcgcaggcga gcgccgtgac ctcggcgccg 43560
gggacgtcgc tcgccgtgcc gccgcgcgac aacatcagca gacggcgtac tccgtagtgg 43620
ccgacgaggt gacgggcgac gatgcccgcc agggtgccgg acccgccggt gatgaggacg 43680
gtgccgtccg ggtcgagcgc cggggcgtcc cccgacggga ccgccggggt caggcggcgg 43740
gcgtacgccc ggccttcgcg cagcaccacg tgcggctcac cgagcccggc ggccgccgcg 43800
aggagcgggg cggcggtgtc cggctcggcg tcgacgacga cgatccggcc ggggtgctcc 43860
gcctgcgcgg tcctgaccag acccgcggcc gcggcggggg cgaggccggg cccggtgtgc 43920
acggccagga ccgcgtcggc gtaccggtcg tcggtgagga agcgccgcag cgcggccagc 43980
acgtcggccc cgaggtcgcg ggtctcggcg agtggggcac cgccggtgcc gtgcgcgggg 44040
agtatgacga cgtccgggac cgccgggtcg tcgagtccac cggtcgtcgc ggtggtgggc 44100
ggcagttccg gtatctcggc aaggccgggc cgcaacaggc cgggaacggc tccctcgacg 44160
gtcaggggac gcctgcgcac cgcgccgacg gtggcgacgg gactcccggt ctcgtccgcg 44220
aggtggacac cggtggcggt gacggcgacc cgcactgtcg tggcaccggt cgcgtggaca 44280
cggacgtcgt cgaacgcgta cggaaggtcg gtgccttccc gggtgagggc gagcgcggca 44340
ccgagcagcg ccgggtgcag gccgtatcgc tcgacatcgg cgtgctgctc gtcggcgagg 44400
gtcacttcgg cgtggacggc gtcgtcgtcg gcccaggcgg cgcgcggccg gggcagcgcg 44460
gggccgtccg tgtgcccggc cctggccagg cggtcggcca ggtcgccgac gtcgaacggc 44520
cgggcggtgg caggcggcca cgtcgacggc atctccggca cggccgacgc cgcccgcgcg 44580
gcgcgggcga ggatcccggt cgcgtgctcg gtccactctc ccgtcccgtg tcgcgcgtgc 44640
acggtgaccg cgcggcggcc gtcttcccgg ggcgccgcca ccgtgacgga gagcgcgagc 44700
ccgccggact gcggcagcgt gaccggggtg tccacggtga acgtctccac ggcgtcgcag 44760
cccgcttcgc cgcccgccgt gatcgccagg tcgagcagca ccgcggcgga cagcaccggg 44820
atgccgtgca cggagtgcgc cagcgggtcg gtggcttcga cccggccggt gagcaccagg 44880
tcgcccgtgc cgggaaccat gaccgccgcg gtcaacaccg ggtgggcgac cggcagttgc 44940
ccggcctggg ccgcgtcgcc cgcggcccgg gagccgagcc agtagcgggt ccgctcgaac 45000
gggtacgtcg gcaggttcgg caggtgcgtc ggcgcggcgc cgatgacctc gggccagtcg 45060
accgcgacgc cgccggtgtg cagccgggcg agcgcggtca tcgcggaccg cgcttcgtcg 45120
tcgccgtgca gcacggggat gccgtcgacg agacgggcca ggttccggtc cgggccgatc 45180
tccaggagcg ccgccccgtc gtacgcggcg acctgctccc cgaaccggac ggtgtcacgg 45240
acctgccgca cccagtactc cggcgtcgcg cagtccgcgc ccgcggccat cgggagcttc 45300
ggctcgtggt aggtcagccg ctgcgcgacg tcccggaact cgtcgagcat cggctccatc 45360
cgcgccgagt ggaacgcgtg gctggtccgc agccgggtga agcggccgag ccgggccgcg 45420
acgtcgagca cggcgtcctc gtcgccggag agcacgatcg acgcgggacc gttgaccgcg 45480
gcgatctcca cgccttcgcg cagcagcggc agcgcgtccc gctccgacgc gatcaccgcg 45540
gccatcgccc cgccgggcgg cagcgcctgc atcagccggg cccgcgccga caccaacgcg 45600
cacgcgtcgt cgagcgacca gacaccggcg acgtacgccg cggccagctc accgatcgag 45660
tggcccacga gcgcgtccgg gcgtacgccc cacgcgtcga gctgggcgct gagcgcgacc 45720
tggagcgcga acaccgcggg ctgggcgtaa ccggtgtcgt ggatgtcgag cccggcgggc 45780
acctggaggg cgtcgaggac gtcacggcgg gtgcgggcga acacgtcgta cgcggcggcc 45840
agttcgtcgc ccatgccggg gcgctgcgag ccctgcccgg agaagagcca cacgaggcgg 45900
cggtccggta ccgccgtgcc ggtgatcagg tccgtgccga tcagggcggc ccggtgggtg 45960
aaggcggtac gggtgagcag ggccgaggcc accgcgcgct cgtccccgcc cccggcgtcg 46020
aggaacgcgc ttacgcgggt ggtgtgttcg ctcagtgctc ggggggtgcg ggctgagatg 46080
agcaggggta cggggtgggt gctggatccg gtgtcggggg cgggagtcgg tcgggggtgg 46140
ctttcgagga tgacgtgggc gttggtgccg ctgactccga aggaggacac ggcggcgcgg 46200
tgcggcctgc tggtctcggg ccaggggcgg gcatccgtga ggagttcgac ggtgcctgcc 46260
gtccagtcga cgtgtgagga gggtgtgtcg acatggaggg tgctcggcag ggtgtcgtgg 46320
tgcatcgcca ggaccatctt gatgatgccc gcgacccctg cggcggcttg ggtgtggccg 46380
atgttggact tcagcgaacc caacaggagc ggcgtcgccc ggtcctgccc atacgtcgcg 46440
aggagcgcgg tcgcctcgat ggggtcgccg agacgggtgc cggtgccgtg cgcctcgacc 46500
gcgtccacat ccgagggctg gagacccgcg ttggccaggg cctggcggat gacacgttcc 46560
tgggagggcc cgttgggcgc ggagagcccg ttggacgcgc cgtcctggtt gacggcggaa 46620
ccccgtacga ccgcgagaac acggtggccg tggcgctccg cgtcggagag ccgctccacg 46680
accaggaccc cggaaccctc ggcgaagccg gtaccgtccg ccgcctccgc gaacgccttg 46740
caccgaccgt ccggcgcgag gccccgctgc tgggagaagt ccacgaatcc ggacggcgac 46800
gccatcaccg tcacgccacc caccagcgcg agcgagcatt cgccggtacg cagcgactgc 46860
cctgcctgat gcagcgcgac cagcgacgat gagcaggcgg tgtcgaccgt gaccgccggg 46920
ccctccagac cgtagaagta cgaaaggcgg cccgagagca cactggtctg ggtacttgtc 46980
gcgccgaaac cgccgcggtc ggcgccggat ccgtacccgt agaagtagcc ccccatgaac 47040
acgccggtgt cactgccccg cagcgtgtgc gggtcgatgc ccgcgtattc gagcgcctcc 47100
cacgacgtct ccatgacgac acgttgctgc gggtccatcg cgacggcctc acgcggactg 47160
atgccgaaga acccggcgtc gaagtcaccc gccccggaca ggaatccacc gtgccggacc 47220
gtcgacgtac ccggatgctc cggatcggga tcgtagagcg cctccacatc ccagccacgg 47280
tccccgggga aggtcgtgat cccgtcaccg cccgactcca acaaccgcca caggtcctca 47340
ggagaggcca ccccacccgg caaccggcac gccatgccca cgatcgccag cggctcgtca 47400
tgtcggcggg ccggggccgg tgcgcgccgc cgggtggcgg tcctcgctcc ggccagctcg 47460
tccaggtgtg cggccagcgc ttgggccgtg gggtggtcga agacgagcgt ggcgggcaag 47520
gtcaggcccg tcgcgtcggc cagccggttg cgcagttcga cgccggtcag cgagtcgaag 47580
cccacctcct tgaacgcgcg cgtcggctcg atggcgtggg cgtcgcggtg gccgagcacc 47640
aaggcggcgc tcgtccggac gagttcgagc atgtcccgcg cggccgtcgg tgcggccgcg 47700
cgccgggcgg ccggtacgag gtcgcgcagg atcggcggga cctggtccga ggcggcgacg 47760
gcggcgaggt cgagccggac cggcacgagt gcggcgcggt cgctgtgcag ggccgcgtcg 47820
aacagcgcga gcccctgctc ggccgtcatc gggatcatgc cgccgcgtgc gatacgggtc 47880
agatcggtgg cggtcagccg tccgcccatg ccgtccgcct cgtcccacag tccccacgcg 47940
agcgagaccg cgggcagccc ttggtcccgc cggtggtggg cgagcgcgtc gaggaacgcg 48000
ttgccggtcg cgtagttcgc ctgccccgcc ccgccgaacg tcgcggagat ggacgagtac 48060
aggacgaacg cggcgagttc gaggccgcgc gtcagctcgt gcagctgcca ggcgacgtcc 48120
gccttgaccc gcagcacggc gtcccactgc tgtggccgca tggtcgccac gaccgcgtcg 48180
tcgacgattc cggccatgtg gacgacggcg cacagccgct cggcgacacc ctcgacgagg 48240
gcggcgagct cgtcccggtc ggtgacgtcg gcggccacgt accgcacgcg gtcgtcctca 48300
ggtgctccgt cgggtcggcc gccgcgagac gccacgacga cctcggcggc ctcgtgcgcg 48360
gtcagcaggt ggtccacgag gcggcggccg agcccgccgg tgccgccggt gacgagcacg 48420
gtcccgccgg acagcgggga tgctcccgtg gacgcggtga cacggcgcag ccgggccgcg 48480
cggaccgtgc cgtcggtgac ccggacgtgg gactcgtcgc cgacggcgag cccggcctcg 48540
acggtggcgg gcgtgatctc gtccgcttcg atcaggccga cgcggcccgg gtgttcggtc 48600
ccggccgtcc ggaccaggcc gccgagagcc tcctgcgcgg ggtcgccggt acgggtgacc 48660
acgacgagcc gggactgcgc ccagcgcggc tcggcgagcc acgtccgcac ggtcgcgagc 48720
aggtcgcggc ccagctcccg ggcccggaca ccgggcgagg tgccagggtc gccgggctcc 48780
acgggaagga ccactaccgg gggcgggtcg ctctcgccta caccgccctc gactacgtcg 48840
ccttcgatta agtcgccctc ggacacgtcg cccccgggca catcggcgag gtacgtccag 48900
ccggggacgg gcgaggcggg tacgggaacc caggcgacct cgaacagcgc ttcggtgccg 48960
ggttccgcgg cccgcacggt caggccgtcc acgtcgagga ccggggcgcc gtgctcgtcc 49020
gtggcgagga tgcggatcgt gtcgccgtcg gcgcgttcga gcagcacgcg cagcgtggtc 49080
gcggcgcgcg cgtgaatccg tacgccggac caggagaagg cgagcctggg ccgctccggg 49140
tccgcgaaga gcgtgccgag cgcgtgcacg gccgcgtcga gcagcacggg gtgcagcccg 49200
taccgggcgt cggtgagctg ctcgccgagg cggaccgacg cgtaggcgcg tccctgcccg 49260
gcccacatcg ccgtcatggc ccggaacgcg ggcccgtacg agatcggcag cgtgtcgtag 49320
aagccggtca ggtcgaccgg ttccgcgtcg gcgggaggcc actccaacgg ctccggatcg 49380
ctggtgtccg cgctcagcgc gccggtcgcg ccgaccgtcc acggccccgc gccggtccgg 49440
cagtgcaggc gcaccggccg ccgccccgac acctcggttc cgaccgtgag ctggatctcc 49500
gtgtcgcgct cttcgtcgac caccaccggc gcgacgatcg tcagctccgc gatcgtcggc 49560
gtgccgagcc gcgcccccgc ttcggcgagc agttccacga gcgccgagcc gggcacgatg 49620
atccgcccgt ccacctcgtg gtcggcgagc cacggctgtc gacggaccga gaacagcgcg 49680
gtggcgaacg cgccctcgcc gtcggcgcgt tcgaccagcg agccgagcag cggatgcccg 49740
gaggtgcctg ccggttccgc gtcgatccag tagcggtcgc gccggaacgg gtacgtgggc 49800
agcggcaccc tccgggactc cccggacggc cagctgacgg gcacaccccg gacccagagc 49860
tcggcgagcg agctggtgaa gcggcgtgcc ccgccgtcgc cccgccgcag cgtgccggtc 49920
accgccgtgt tcggatgccc ggcgagcgtg tccgcaagcg cggtggtgag taccgggtgc 49980
gggctggcct cgacgaacac gcggtagccg agctcggcga ggcgggcggt cgcggcgccg 50040
aagcgaacgg ggcggcgtac gttgtcgtac caataggcgg cgtcggcggg tcggtcgagc 50100
cacgcctcgt cgacggtgga gaagaacggg acctccggcg cacccggggt gaggtcagcg 50160
agcgcgtcga gcagcgcatc gcggatggtc tcgacgtgcg cggtgtgcga ggcgtagtcg 50220
acggcgatcc ggcgggcgtg gggcgtggcg gcgagcagtt cctcgacggc gtcggccgct 50280
ccggcgacga cgatcgacgc gggcccgttg accgcggcga cctccaggcg cccggcccac 50340
gcggccgcgt cgaagtcggc gggcggcacc gacaccatgc cgccgtgccc ggccagttcg 50400
gtggcgacga gtcggctgcg cagtgcgacg accttcgcgg cgtcgtccag tgtgagcacc 50460
ccggcgacgc aggccgcggc gacctcgccc tgggagtggc cgaccaccgc ggcgggggcg 50520
accccgcgcg agcgccacag ttcggcgagc gccaccatca tcgcgaacga cacgggttgc 50580
acgacgtcga cccggtcgag cgcgggcgcc ccgggccgcc gggcgatgac gtcgagcaga 50640
tcccatccgg tgtacggggc gagcgcctcg gcacactcgc cgagccgccg cgcgaacacg 50700
ggctcggtgg cgagcagttc cgcgcccatg ccgtcccact gggaaccctg cccggggaac 50760
acgaacacgg cgcgcgcgtc ggtgacgtcg gcggttcccc gcaccacgcc cggcacttcc 50820
tcgccgcggg cgaacgcctc cgcgtcccgt gcaggcacga ccgcccggtg ccgcatggcc 50880
gtccgggtgg tggcgagcga gtgcccgatc gcggccgcgg gggcggtgag cgcgaccagt 50940
cgtcccgcga cgtcccgcac cccgtcgggt gtgcgggccg acaccggcca gacgacgccc 51000
tccggcaccg gttcggtggc gggaagggtg gcgggtgcgg cgggcggccc ggcctcgatc 51060
acgacatggg cgttggcacc gctgatgccg aacgacgaga cgcccgcgcg ccggacgcgg 51120
ccggtgaccg gccacggttc gttgcggcgc agcagccgga caccaccgcc ccagtcgacg 51180
tgccgggacg gttcgtccac gtgcagcgtg cgcggcagga cgccgtgccg catcgcgagg 51240
accatcttga tcaccccggc gacgccggcc gctgcctggg tgtggccgag gttcgacttg 51300
agcgagccga tcagcagcgg atgcacgcgg tccagcccgt acgccgcctc cagcgcctgg 51360
gcctcgatgg gatcgccgag acgggtaccg gtgccgtgcg cctccacggc gtcgatgtcg 51420
cccggtacga gcccggcgtc atcgagcgcg cgctcgatga cgcgccgctg cgcggggccg 51480
ttcggggcgg aaaggccgtt cgacgcgccg tcggagttga cggcggagcc gcgcaccacc 51540
gcgagcaccg ggtggccgag acgggtggcg tcggagagcc gctcgacgat caggacaccg 51600
gcgccctcgg cgaaactggt gccgtcggcg gtgtccgcga acgccttggc ccggccgtcc 51660
ggagccagcc cgcgctggcg ggagaactcg acgaacccgg tcgtcgtcgc catcaccgtg 51720
acaccgccga ccagcgcgag cgagcactcc cccgagcgca gcgaacgcgc ggcctggtgc 51780
aacgccacca gtgacgacga gcaggccgtg tcgacggtga cggaagggcc ttcgagcccg 51840
aagtagtagg agagccgccc ggagagcacg ctcgtcggcg tgccggtcgc cccgaagccg 51900
cccaggtcga cgcccgcgcc gtacccctgc gtgaacgcgc ccatgaacac acccgcgtcg 51960
ctgccgcgga cgctcgcggg caggatgccc gcccgctcga acgcctccca cgacacttcg 52020
aggatcagcc gctgctgcgg gtccatggcg agggcctcgc gcgggctgat cccgaagaac 52080
tcggcgtcga agtcggccgc cccggcgagg aagccgccgt gccgcacgga gaccttgccg 52140
atcgcgtcgg ggtccggatc gtagagcgcg gcgaggtccc agccgcggtc ggtggggaac 52200
tcggtgatcg cgtcaccacc ggattcgacg aggcgccaca ggtcttccgg cgtgtccacg 52260
ccaccgggca tccggcaggc catggccacg atcgccagcg gctcgtcgcc cgccaccgcc 52320
agtgtcggta cggtcctctg agcggcggca gcggcagcgg cccccggtga ttcctcatcg 52380
ccccgcagtt cctccgcgag acgcgcggcg agcgcgtccg gcgtcgggtg gtcgaagacg 52440
gccgtcgcgg agagcctgac gccggtcgtc tcggcgaggc tgttgcgcag ccggatgccg 52500
ctgagcgagt cgatgccgag gtccttgaac gcggtcgcgg gcccgatctc ggaggcatcg 52560
gcgtggccga gtacggcggc ggtggccccg cacacgacgg ccagcaggtc gcggccgctg 52620
tcctcaccgg tacggacggt acgacgctcg acccgccgac gagcgggctc ggcgggaatc 52680
gccgcgacca cgaacggcac gtcggtggcg aggctcgcat cgaggaagtg gttgccctcg 52740
gcctcggtga gcggacggaa accgtcccgc acccgctgcc gttcggtgtc gccgagttgc 52800
ccggtgagtg tggtggtggt gtgccacatg ccccaggcga tggtggtggc gggttggttg 52860
tgggtgtggc ggtgggtggc gagggcgtcg aggaaggcgt tggcggcggc gtagttggct 52920
tggccggggc tgccgagggt ggcggcggcg ctggagtaga ggacgaagtg ggtgaggggt 52980
tggttttggg tgtggtggtg gaggtgccag gcggcgtcgg ctttgggttg gaggacggtg 53040
gtgaggcgtt ggggggtgag ggtgtgcagg ggggtgtcgt cgagggtggc ggcggtgtgg 53100
aagatgccgg tgaggggttg gggtatctgg ttgagggcgt gggtgatttg ggtggggtcg 53160
gtgaggtcgc aggggatgtg ggtgccgggt gtggtggggg gtggtggggt gcgggagagg 53220
aggtaggtgt gggggtggtt gaggtggcgg gcgaggattc cggcgagggt gccggagccg 53280
ccggtgatga ggatggcgtg gtgggggttg aggggtgggg tgggtgttgt ggggtggtgg 53340
gggttggggt tggggttggg gttggtgcgg ggggtgagtg gggtgaggtg gggggtgtgg 53400
agggtgttgt tggtgaggcg taggtggggt tggttgaggg tggtgagttg ggtgaggggg 53460
agtggggtgt gggggtggtg ggtttctatg aggtggatgc ggcctgggtg ttcgttttgt 53520
gcggtgcggg tgaggccggt gacggcggcg cctggggggt cggtggtggt gtggatgatg 53580
agggtgtggt tggtggtggt gaggtggtgt tggagggcgg ccaggacgcg tgtggtttgt 53640
gtgtgggtgc gtgtgggtgt gctgtggggg ttggtggggt cgtcttcggg gtcgtcgggg 53700
tgtgtggcgg tgatgagggt gtagccctcg ggcaggctgt cggcaccgtc gtagtgcgcc 53760
tccgccaccg gcaaccactc aaggccgagc aggttcggtc ccgacggcgt ggcgctgcgc 53820
ggccgcagca ccaacgcgtc cacggacacg acagggcggc cgtccggatc ggccacctgc 53880
acggcgacgc ccgcagggcc tcgggtgagg gcgacgcgca cggcggtggc gccggtggcg 53940
tgcaggcgta cgcccgtcca cgagaacggc agctccaact cgtcgcccgc gtcgaggcgc 54000
ccggcatgca gggccgcgtc cagaagcgcc gggtgcactc cgaaacggtc cacatcggcg 54060
gcacggtcct cggggagcgc cacctcggcg tagatcgtgt cacccgcccg ccatgcggcg 54120
cgcagcccct ggaacgccgg gccgtaggtg tagcccgcgg ccgcgagctg ctcgtagaac 54180
tggtccaggc ttgccggttg cgcgccggtc gggggccatt gcgggaagga gttcggggcg 54240
ggggtggtgt cggtggcgct ggtggtgagt gtgccggtga cgtggcgggt ccaggtgtcg 54300
gttccttcgg ggcgtgcgtg gacgctcacc gggcggtggc cggtggtgtc gggctggtcg 54360
acggtgacgg tgaggtcgac ggcaccggtg acgggcagta cgagcggggt ctcgatgacc 54420
agttcgtcga tggtgtcgca gccgacctcg tcaccggccc gcaccacgag ttcgaggaac 54480
gccgtgcccg gcagcaacac cgtgtcctgc acggcgtgat cggccagcca cgggtgcgtg 54540
gccagcgaca gcttgcccgt gagtagtacg ccgtcgctgc ccggcagcac cgccgcactc 54600
gacaggaacg gatggccgat ccccgcgccg cccgccgggg cgggctgcaa ccagtagcgc 54660
ttgtggtcga aggggtaggt cggcaggtcc aacacgcggt gctgggcggg ctcgatcagg 54720
gtggtccagt caacgtccgc gccctgggtc caggcctcgg cgagcgcggt caggaaccgc 54780
tcccagccac cgtcatcggt acgcagggaa gcgaccgtgc gctcctggtc gagggcgggc 54840
agcagcaccg gatgggcact gcactcgatg aacagcgaac cgtccagctc accggtcgcg 54900
gtatccatcg ccaccggctg acgcaggttg cggtaccagt agtcgtcatc gaccggttcg 54960
gtcacccagc cgctgtcgac cgtcgaccac cacgggacgg aaggtgcgct gctggtgatc 55020
ccccctaaga cgtcggccag ttcgtcctgg atcgcttcca cgtgcggggt gtgcgaggcg 55080
taatccaccg cgatccggcg cacccgcaca cccgcagcct cataccgggc cagcacccgc 55140
tccaccgccg ccggatcgcc cgcgaccacc gtggattccg gaccattgcg ggccgcgatc 55200
cacaccccct ccatcacctc aacggcactg gcgggcaagg cgattgacgc catcgccccg 55260
tgcccggcca gccgcgcagc gatggtctgg ctgcgcaagg ccacgacccg cgcggcgtcc 55320
tccagactca acgctcccgc cacacacgcc gcggcgatct ccccctgcga atgccccacc 55380
accgcatccg gcaccacacc atgggcctgc cacagtgcgg ccaggctcac cgccaccgcc 55440
cacgacgcgg gctgcaacac ctccacccga tcagccacca ccgcctcacc cagcacatcc 55500
agcacatccc accccgtgtg cggctccagc gccgccgcac actcccgcat ccgcgccgcg 55560
aacacctccg agacgcccat caactcccgg cccatgccga cccactgcga gccctgcccc 55620
gggaacacga acaccgttcg cgccccctcc acagcgactc cggcaaccgt gctctccccc 55680
agcaacaccg cccgacggcc gaacaccgcc cgcccacgca ccagaccatc cgccaccgcg 55740
cccaggtccg ccccaccccg cacatactcg ccgagccgct ccacctgcaa cgccaagctc 55800
gactccgtac gcgccgacac cggcaacggc accagacccg ccgacgaccc cccgctacga 55860
accgacgact ccgcaacccc ctccaaaatc acatgcgcat tcgtgccgct cacaccgaac 55920
gaggacacac ccgcacgccg cgccccaccc gactccggcc acggtcgtgc ctccgtcacc 55980
acctcgacgg cccctgccga ccagtccaca tgtgacgacg actcgtccac gtgcaacgtc 56040
cgcggcacca ccccacgccg catcgccatc accatcttga tgacacccgc gacgcccgcc 56100
gccgcctggg tgtgaccgac gttcgacttg accgaaccga gcagcagcgg gacttcacgt 56160
tcttgcccgt acgtcgccag aaccgcctgc gcctcgatcg gatcgccgag gaccgttccc 56220
gtaccgtgcg cctcgaccgc gtccacgtcg gtgccgttca gcccggcgtt cgccagggcc 56280
tgcctgatca cgcgctgctg ggcgacaccg ttgggcgcgg agaggccgtt ggacgcgccg 56340
tcctggttca ccgccgaacc acggacgacc gcgagaacgg tgtgaccgtt gcgctccgcg 56400
tcggacagcc gttccacaac caggacaccg acgccttcgg cgaacccggt gccgtccgcc 56460
gaatcggcga acgccttgca ccgcccgtcc ggggagagcc cgcgctgccg ggagaactcc 56520
acgaagctcc ccggtgtcgc catcaccgtg acaccaccgg ccaacgccag ggagcactcc 56580
cccgaacgca gcgcctgcgc cgcctggtgc agcgcgacca gcgacgacga gcacgcggtg 56640
tccaccgtca cggccgggcc ctggagtccg tagaagtatg agaggcgccc ggacaggacg 56700
ctcgtctggg tcgccgtgac gccgagtccg cccaggtcgc ggcccgcgcc gtacccctgg 56760
tggaacgcgc ccatgaacac gccggtgtcg ctctcccgga gcgtgtccgg gacgatcccc 56820
gcgtgctcga acgcctccca tgaggtttcg aggaccagac gctgctgcgg atccatggcc 56880
agcgcctcgt tcgggctgat cccaaagaac gcggcgtcga acccggttgc ctcggtgagg 56940
aagccaccgt ggcgggtcgt cgaacggccg accgcgtccg gatccgggtc gaacagcgcg 57000
tcgacgtccc agccgcggtc ggcggggaac tcggtgatcg catccgtgcc ggacgccacg 57060
agccgccaca ggtcctcggg ggacgtcacg ccgccgggca ggcggcaggc catcccgacg 57120
atcgcgacag gttcaccgga acccagggca gccttggcgg cgggcgccgc cacagagccc 57180
gcgaggtgcg cggcgaacga acgcggcgtg gggtggtcga acgccgtgga cgcgggaacg 57240
cgcaggcccg tccgcgcggt gacggtgttc gcgaattcga cagtggtgag tgagtcgaga 57300
ccgttctcgc ggaacgtacg gtccggcgcg cagcgttcgg cgcccggcag accgaggacc 57360
gtggcgacgc tgtcgcggac caggtcgagc agtaccttct cccggtcggc gtcggccgcc 57420
gcgaggaggc tcgcccactc cggtcctgcg gcgccgggct cggcctgatc tgtcggcccg 57480
gccggtcccg ccactccggc gagtccggag aggatcggtg gcgtcgcgcc tgccatcgcc 57540
tcggcccgcg cccctgcgga accgacccgg gtgacgacgt acgagccgcc gccctcgatg 57600
gcctcttcga gcaactcacc ggtcagcggc gcctgttcga tgccgggcag cccgtggacc 57660
gtgacgatcg ggagcccttc cggggcccgg gaccgggcat acgcgtcggc accggccgga 57720
tcgccgagca ggacgtgcgc gagcgtgctc gcgttcacgc cctgctcggc ttcctcggcc 57780
ccctcggctt ccgcagcgct gctggacacg tgtgtgcggc ccgtctcgtc gcgcagcagc 57840
ccggcggcgg cgtcggcccc ctccccggtg accaggaccg gcgagtcggg accgagcgga 57900
tgcggcacgg tgaggaccgt cttgccggtg ttcctggcct ggctcatcca cccgaacgcg 57960
tcccgcgcac ggcggatgtc ccacggccgc accggcagcg ggcgcagctc gccgcggtcg 58020
aacaactcca ggagcagttc gaggatctcc cgcagccgcg cggggtcgac gtcggacagg 58080
tcgaagggct gttggacgtc gtgacggatg tcggtcttgc ccatttcgac gaaccggccg 58140
cccggtgcga gcaggtcgac ggaggcgtcg aggaattcgc cggtgaggga gttcagtacg 58200
acgtcgaccg gggggaacgc gtcggcgaac gcggtcgtac gggagttcgc gacgtggtcg 58260
gcgtcgaagc cgtcggtgag cagcaggtgc tgtttggcgg ggctcgcggt ggcgtacacc 58320
tccgcaccca ggtgccgcgc gatctgccgg gcggccgagc cgactccacc ggtggccgcg 58380
tggatcagaa ccttctggcc cggccgcacc tctcccgcgt cgacgaggcc gtaccacgcc 58440
gttgcgaaca cgatgggcac ggacgcggcg accgggaacg accagtcccg cgggatccgc 58500
gcgaccagcc tccggtccgc gacgacgctg cgccggaacg cgtcctgcac gagaccgaac 58560
acgtgggccc cgggcaccag gtcgtcgacg ccgggcccga cctcggtcac gatcccggcg 58620
gcctccccgc ccatcgcacc gtcgcccggg tacgtgccga gcgcgatcag tacgtcgcgg 58680
aagttcagcc ccgcggcgcg gacgtctatg cggacctcac cggcggccag cgggcgcggc 58740
ggggcgtccg aggggacgac ggcgaggtcg cggagcgtgc cggaggcggg cgggcgcagc 58800
gcccacggtg tggtgggcag gggggtggtg ttcgcacgga cgaggcgcgg cacgtaggcc 58860
acaccggatc gcagcgctac ctggggttcg ccgagcgccg ccgcggcggc gacgagctcg 58920
tcggcctcgt caccgttgtc cgcatccgtg tccaccagta cgaacgaccc cggctccgca 58980
gcctggcgca cgagcgcttc gtcccagagg agggcctggt ccgtgtccgg tacctcggca 59040
gggccgatcc cgaccgcccg ccgggtgacc actgtccgag cctgcgacac cgtgtcgggc 59100
agctcgcgcc gctcccagac cagctcgcac agtgccgcct cgccgctgcc ggtgccgacg 59160
aggcgggccg ggaggcccgc gagctcgccc cggcgcacct tgcccgacgc ggtgcgcggg 59220
accgtggcga cgtgcaggat ctcgtcgggc accttgaagt aggcgagttg gcggcggcac 59280
tccgcgagga tcgcttccac gggtacgccg ggtccttcgg gcacgacgta gagcacgggt 59340
atctcgccga ggacggggtg tgggcggccc gccgcggcgg cgtccctgac gcccggcacc 59400
tcctgggcca cggactcgat ctcccggggg tggatgttct ccccgccgcg gatgatgagt 59460
tccttgaccc ggccggtgat cgtcacatgc ccggtctccg cctggcgtgc caggtctccg 59520
gtgcggtacc agccgtccac gagcacctgg gcggtcgcct cggtctgcgc gtggtagccg 59580
agcatgaggc tcggtccgct cgcccacagc tcgccctcgt cgccgcgcgc cacgtcggcg 59640
ccggtcaccg ggtcgacgaa ccgcagcgaa aggcccggga cgggcagccc gcacgagccg 59700
ggaaccctgg cgtcggtcag ggtgttggcg gtgagcgatc cggtggtctc ggtgcagccg 59760
taggtgtcga gcagcggcgc gccgaacgcc gcttcgaagc ccgccgtgag cgacgccggt 59820
gcggtggaac ccgcgaccag cgccacgcgc agcgcgcggg tctcctgttc gccggagacg 59880
gcaccgagga ggtagcggta catcgtcggc acgccgacca gcacggtgca cgggtgttcg 59940
gcaagcgcgt cgaggacgtc acgcgcgacg aagccgccga ggatgcgggc ggacgcgccg 60000
acggtgagga ccgcgagcag gcagagatgg tgcccgaggc tgtggaacag cggggcgggc 60060
cagagcagtt cgtcgtcctc ggtgagctgc caggacggca cgtcgcagta catcgcggac 60120
cacaggccgc tgcgctgcgc ggagacgacg cccttggggc gccccgtggt tccggacgtg 60180
tagagcatcc aggcgggttc gtccaggccg aggtcgtctc ggggcgggcg cggcggttcg 60240
gttcccgcca aatcctcgta cgcgatgcag cccggctcct gtcgccctgc gagcaccacg 60300
gtggcatcgg tgccgatccg gcgtacctgg tcgaggtgca ggtcgtcggt gaccagcacg 60360
gtcgcgccgg agtccgtcag gaagtgggcg agctcggcgt cggcggcgtc cgggttgagc 60420
ggcaccgcga cggcggcggc acgcgcggcg gcgaggtaga cctcgatcgt ctcgatcctg 60480
ttgccgagca gcagcgcgac gcggtcgcca cggcccacgc cggacgcggc gaggtgtccg 60540
gcgatcctgc cggtcctgag ctggagccgc tcgtacgtca cggcgcgtcg ggaatccgtg 60600
taggcgaccc ggtcgccgtg ccgctcggca ttcacgcgca gcaattcatg caggggccgg 60660
atggattccg cacgcgccat gggaacacct ttctctctgc tgtccgcacg gcagcacgaa 60720
gccgagcacc tgcgaatgtc ggcgacgcta acagcgattc cctgacgatc ccgctgccga 60780
tcccccctga ccatccccct gccttggccg gactcccctg ttgcccatct agggggttgc 60840
acgaataacg tcacacgtac ttttctgcct cgtgaccgac tacggaacgg caggaagggt 60900
gaggttatgt ctgcgcccgt cgcggcaccg tactgccgct tcgagaagat cgggtcgccg 60960
gacctcgaag acgacgagac ggtactcggc gtcatcgaac acggcaccgg ccataccggg 61020
gcgtcgctgg tggacggcgt cccgcgaacc gccttgcaca ccacgacccg tgacgaggag 61080
gcgttcgccg aggtctggca cgcggagccg cccgtcgagt ccggtacgga cgacggcatc 61140
gcgtgggccc gcaccggcga gtacctgttc ggtgtggggc gcgtccccga gagccgcagg 61200
tacgccgatg ccgtctcggc gctctacacg cgcctcttcg ggctgacccg gtcgctggga 61260
tacccgctgc tcgcccgtac gtggaactac gtcagcggca tcaactcggc gaacgcggac 61320
ggcctcgagg tgtaccggga cttctgcgtg ggccgcgccc aggcgctcga cgagggcggc 61380
atcgacccgg cgagcatgcc cgcggccacc ggcatcggca cgcacggggg cggcatcgcc 61440
tgcgcgttca tcgcggcccg cggcggggtc cgggtcaaca tcgagaaccc cgccgtcctc 61500
acggcacacc actaccccgc ggcatacggc ccgcgctccc cggtcttcgc gcgggccacc 61560
tgggtgggcc cgccggacgg tggccggctg ttcgtttccg cgacggccgg cattctcgga 61620
cacgagacga cgcaccacgg tgacgtgacc ggtcagtgcg aggtcgccct ggacaacatc 61680
gcccgggtcg tcggcgcgga gaacctgcgc cgccacggga tccggcgggg gcacgtcctc 61740
gccgacgtcg accacctcaa ggtctacgtc cgccgccgcg aggacctcgc ggcggtgcgc 61800
cgcgtctgcg ccgcccgcct gtcgagcacc gcgaccgtcg cgatattgca caccgacatc 61860
gcccgcggcg acctgctcgt cgaaatcgag ggggtggtgc ggtgacatca cacggaaaga 61920
ggccgggcac tctgcgcctt ggcggttccc caaagaaacg gaattcaacg aatcgggaaa 61980
tagtcgccgc cgaccgggcc gagccgttgc tcgcgtcttt cgcacagcgg cgcatctggt 62040
tcctccagca attggatccg gacagcaatg cctacaatct tccgctcgtg cggcgcctgc 62100
gcggtcctct tgacccggcg cttctggagc gcgcgctcac gctcgtcgtg gcgcggcacg 62160
aggcattgcg gacggtgttc gacgccgcgg acggcgagcc cgtccagcgg gtgcttcccg 62220
tcccgtcccg gatcctgcgg cacacgcggg ccgacggcga gcagggcgcc gcccggctcg 62280
tccacgacga gatcgccgcg ccgttcgacc tctccaccgg gccgttgatc agggctctgc 62340
tgatccgcgt cggtgacgac gaccacgtcc tcgcggtgac cgtgcaccat gtcgccgccg 62400
acggctggtc gttcgggctt ctccagctcg aactcgccgc gcactgcacg gcacttcggg 62460
acacgtcccg tcccgccgtg ctgccgccgc tgccgctgca gtacgccgac ttcgccgcct 62520
gggagcggcg cgaactcacc ggcgccgggc tcgaacagcg cctggcctac tggcgcgacc 62580
ggctcagcgg cgcccctgcc gtgctcaagc tgcccaccga ccgcccccgc ccgcccgtgg 62640
ccgacgcgga cgcgggcatg gtcgagtggc ggccaccggc cgaactggcc gccgcggtcc 62700
accgactggg ccgcgacgcg ggcacgtcca cgttcatgac gctcctctcg gcgttccagc 62760
tcgtcctcgc ccggcactcg ggcacccggg acgtgctggt cggcacgccc gtcgcgaacc 62820
gcacgcggac ggagttcgag ggcctgatcg gcatgttcgt caacaccctc gcgctgcgcg 62880
gcgacctctc cggcgacccg tcgttccggg agctcctgga ccgctgccgg gccacggcca 62940
cggacgcgtt cgcccacgcc gacctgccgt tcgagaacct catcgaggtc gtcgcaccgg 63000
accgcgacct gtcggtcaac ccggtcgtcc aggtgctgct gcaggtgttg cggcgcgacg 63060
ccacgacggc cgcgctgccc ggcgtcacgg ccgagccgtt cggcaccggc cgctggttca 63120
cccgcttcga cctcgagttc cacgtgtacg aggaggcgga cggcgctctc accggtgaac 63180
tccgctacag ccgggcgctg ttcgacgagg aacggatcac gcggctgctc gacgagttca 63240
cggcggtgct gcgggcggcc gccgccgcac ccgacacacg gctgtcccag ctgccaggtg 63300
acgacgcgac gccgacaccc gcgatcccct cgaacgacac ggcgcgggaa ctgcccgtcg 63360
acacactgcc ggaactgctg gccgggtacg ccgcacggac ccccgacgcc gtggccgtca 63420
cggatccgcg gacctcactc acgtacgcgg accttgaccg gcgcgcgaac cgcctcgcgc 63480
acctgctccg cgcgcgcggc accaccaccg gcgacctcgt cggaatctgc gccgaccgcg 63540
gcgtcgacct cgtcgtcggc atcgtaggga tcctcaaagc gggtgccgcg tacgtgccgc 63600
tcgatcccga acacccgccg gagcgcacgg cgttcgtcct tgccgacgct caactgaccg 63660
cggtggtggc acacgaggcc taccgccatc ggttctccga tgtgccgcac gtggtgacgc 63720
ccgacgaccc ggacctcgac cggcagccgg acacggcgcc gcacctcacg ctcgaccggg 63780
acagcctcgc ctacgcgatc tacacgtccg gttcgaccgg caaacccaag gccgtgctca 63840
tgcccggcgt cagcgccgtc aacctgctgc tctggcagga gcgcacgatg ggccgcgaac 63900
cggcgagccg cacggtccag ttcgtgaccg ccacgttcga ctactcggtc caggagatct 63960
tctccgcgct gctcggcggc acgctcgtca tcccgccgga cgaggccagg ttcgacccgc 64020
cgggactcgc ccggtggatg gacgagcagg cgatcacgcg gatctacgcg ccgacggccg 64080
tgctgcgcgc gctggtcgaa cacgtcgacc cgcacagcga tcagctctcc gcgctccggc 64140
acctctgcca gggcggcgag gcgctgactc tcgacgcgcg gctgcgcgaa ctctgccgac 64200
accggcccca cctgcgcgtc cacaaccact acggcccggc cgagagccag ctcatcaccg 64260
ggtacacgct gcccgccgac cccgacacgt ggcccgccgc cgcaccgatc ggtccgccga 64320
tcgacaacac ccgcatccat ctgctcgacg acgcgctgcg accggttccc gacggcatgc 64380
cggggcagct ctgcgtcgcc ggcgtcggcc tcgcccgcgg ctatctcgcc cgccccgaac 64440
tgaccgccga gcgatgggtg cccggcggcg ccaccggcga ggaacgcatg tacctcaccg 64500
gcgacctggc ccgccgggcg cccggcggcg acctcgactt cctcggccgg atcgatgacc 64560
aggtcaagat ccgcggcatc cgcatcgagc cgggcgagat cgagaacgtc ctcgccgagg 64620
acgcccgcgt cgcacacgcc gccgtgtccg tacgcgagga tccgcggggc gagaagttcc 64680
ttgccgcgta cgtcgtgccg accgccggtc cgcacggcga cggcctcgcc gcgtcgttgc 64740
gcgaaggtct tgccgaccgg ctgcccgcct atctcgtgcc gtccgccgtc gtcatcgtgg 64800
acgcgctgcc ccggaccacg agcggcaagg tggaccggcg cgcgctgccc gacccggcgc 64860
ccgactcggc ggcgccccgg aaggtcgcgc cccgcaacca cgccgaacgg gtggtgtgcc 64920
ggatcttcca ggacgtgctc ggcgtcccgc gggtcggcat cgacgacgaa ttcttcgcgc 64980
tcggcgggca ttccctgctc gccacgcgag tcgtctcgcg gatccgcgcc gagctgggtg 65040
cggacgtcgc gctgcggacg ctcttcgacg cacggacccc cgcggcgctc gcccgcgccg 65100
tggacgaggc aggacccgcc gccctgcccc cgatcctgcc ctccccctgt gccgggccca 65160
cccccatcac cgccgcacag gagcagatgc tgcactcgca cggatccctg ctcgccgccc 65220
cttcctacac ggtcgccccg tacgggttcc ggctgcgcgg gccgctcgac cgcgacgcgc 65280
tggacgcggc actgacccgg atcaccgcac ggcacgagcc gttgcggacc ggattccggg 65340
gccgggagca gatcgtcggg ccgcccgtcg cggtacgtgc cgaggtggtc gatgtgccgt 65400
ccggtgacgt cggcgccgcg gcccgggtgg cccgcgagga gctggcccgg ccgttcgacc 65460
tggtggccgg accgttgctg cgcgccgtgc tcctgccgct gggcaccgag gaccacgtac 65520
tgctgctgat gctccatcac ctcgccggtg acggctggtc gttcgacctc ctggtccggg 65580
aactgtcggg ggcctcgccc gacctgccgg tgtcctatcc tgacgtggcc cgctgggagc 65640
ggatcccggc cgtcgtcgcg gcgcgggagg acgaccgggc gtactggcgc cgacagttcg 65700
aaggtgccgg cgcgcccgag ctgcccacgg tccggccccg gggcacgacc gcgccggacg 65760
ggcgggcctt cctctggacg ttcgacgacg ccacggtcgc ggcggcacgc cgggtcgccg 65820
atgccaggaa cgcgacgctg cacgaaaccg tgctcggcgc cttcgccctg gtcgtggccg 65880
aggccgccga cattgatgac gtgctcgtcg cgacgccgtt cgcggaccgg gggcacgccg 65940
ggaccgacca cctcatcggg ttcttcgcga aggtactcgc gctgcgcatc gacgtcggca 66000
agggcagcgg cggcggtggc acaccgtcgt tcgccgaggt cctgcgccgg gtgcacaccg 66060
cgatgaccgg cgcccacgcc catcagtcgg tgccctactc ggcgatgcgc gcggcggacc 66120
ccgcactgcc gccgactccc gtgtcgttcc agctcatcag cgcgctcagc acggaactgc 66180
ggctgcccgg gctgcgcacc gagccgtttc ccgtcgtcgc cgagaccgtc gacgagatca 66240
acggcgagct gtcggtcaat ctcttcgacg acggtcgcac cgtctcgggc gcggtcgtcc 66300
acgacgccgc gctgctcgac cgcgcgaccg tcgacgacct gctcactcgg gtggagtcga 66360
cgttgcgcgc cgccgcaggc gacctcaccg tacgcgtcac cggtcaagtg ggaagcgagt 66420
agccgtgccc gaacaggaca aaacggtcga gtacctccgc tgggccacca cggaactgca 66480
gaggacccgg gcggaactcg ccgcgcacag cgagcccttg gcgatcgtgg gcatggcctg 66540
ccgcctgccg ggcggggtgg cgtcgccgga cgatctgtgg cggctcctgg agtccggcgg 66600
cgacggcatc ggcgccttcc ccggagaccg cggctgggag accggcgccg acgggcgcgg 66660
cggattcctg tccggggcgg ccgggttcga tgccgcgttc ttcggcgtca gtccgcgtga 66720
ggcgctggcg atggatccgc agcagcgcgt cgtcctggag acgtcgtggg aggcgctcga 66780
acacgcgggc atcgacccgc acacactgaa cggcagcgac accggggtgt tcctgggggc 66840
gttcttccag gggtacggaa tcggtgccga cttcgacggg tacggcacca cgagcatcca 66900
caccagcgtg ctttcgggcc gcctttcgta cttctacggc ctggagggcc cggcggtcac 66960
ggtcgacacg gcgtgttcgt cgtcgctggt cgcgctgcac caggcagggc agtccctgcg 67020
taccggcgaa tgctccctcg ccctggtcgg cggcgtcacg gtcatggcgt cacccgcggg 67080
cttcgcggac ttctccgagc agggtggcct ggcgccggac gggcgctgca aggcgttcgc 67140
cgaggcggcg gacggcaccg ccttctccga gggctccggg gtcctggtcg tggaacggct 67200
ctccgacgcc gaacgccacg gccaccgtat tctcgcggtc gtacgaggct ccgccgtcaa 67260
ccaggacggc gcctccaacg gactctccgc acccaacggg ccctcccagg aacgcgtcat 67320
ccgccaggcc ctcgcgaacg cgggcctcca gccctcggac gtggacgcgg tcgaggcgca 67380
cggcaccggc acccgcctcg gcgaccccat cgaggccacc gcactcctcg cgacctacgg 67440
acaacaccgt acgaccccgc tcctgttggg ttcgctgaag tccaacatcg gccacaccca 67500
agccgccgcg ggcgtcgcgg gcatcatcaa gatggtcctg gcgatgcacc acgacaccct 67560
gccgcccacc ctccacgtcg acacaccctc ctcacacgtc gactggacga caggaggtgt 67620
cgagctcctc accgatgccc ggccctggcc caccaccaca ggcccgcgcc gcgccggtat 67680
ctcctccttc ggagtcagcg gcaccaacgc ccacgtcatc ctcgaaagcc ccactccggt 67740
tccctccccc ggcgccgaac ccggcgcccg ccccgtaccc ctgcccatct cagcccgcac 67800
tcccgaagca ctcgacgaac acaccatccg catccgtgcg ttcctcgacg acaaccccgg 67860
cgcggaccac gtcgctgtcg cacagacgct cgcgcggcgc acccctttcg agcaccgcgc 67920
cgtgctgctc ggcgacacgc tcatcaccgc ggacccgaac gcgggctccg gtcctgtcgt 67980
cttcgtctac tccgggcaga gcacgctcca cccgcacacc ggtaggcaac tcgcggccac 68040
gtaccccgtg ttcgccgacg cgtggggcga ggtcctcggt catctcgacg ccgatcaggg 68100
tcctgccacg cacttcgccc accagatcgc gctcaccgcg ctcctgcggt cctggggcat 68160
cgccccgcac gcggtcatcg gtcactccct cggtgagatc agcgccgcgt gcgcggccgg 68220
tgtcctctcc ctcggcgacg cgagcgcgct cctcgccgcc cgcagccgtc tcatggacga 68280
gctccccgcg ggcggcgcca tggtcaccgt gctgacgagc gaggagaacg cgctccgggc 68340
gctgcggccc ggggtggaga tcgccgcggt gaacggcccg cactccgtcg tgctctccgg 68400
cgacgagggc cccgtgctcg ccgtcgcaca gcagctcggc atccaccacc gcctgccgac 68460
ccgccacgcc gggcactccg cgcgcatgga tccgctcgtc gcgcccctgc tcgaagccgc 68520
cagcggcctg acgtaccacc agccgcgcat cgccatccct ggagatccca ccaccgccgc 68580
atactgggcg cgtcaagtcc gcgaccaggt gcgcttccag gcacacgccg agcggtaccc 68640
gggcgccacg ttcctggaga tcgggcccaa ccaggacctc tcccccgtcg tcgacggcat 68700
tcccacccag accggaacgc ccgacgaggt tcaagcactg cacaccgcac tcgcccgcct 68760
gcacacccgt ggcggcgtgg tcgactggcc gaccgtgctc ggcggtgatc gcgcgcccgt 68820
cgcgctgccc acgtatccgt tccagcacaa ggactactgg ctgcgggcca ccgcccaggc 68880
ggatgtgacc ggcgcgggac aggagcaggt ggcgcacccg ctgctcggcg ccgcggtcgc 68940
gctgcccggc accggcggaa ccgtcctgac cggccgcgtc tcgctcgcct cccacccgtg 69000
gctcggcggg cacgccgtca acggcaccgt gctcctgccc ggcgcggcgt tcctcgaact 69060
cgcggtgcgc gccggggacg aggcgggctg cgacctgctc cacgagctcg tcgtcgagac 69120
accgctgacg ctgcccgcga ccggctccgt ggcgatctcc gtcgaggtcg ccgagcccga 69180
cgacacggga cggcgggcgg tcaccgtcca cgcgcgggcc gatggcgccg tgctgtggac 69240
ccggcacgcc accgggttcc tcggcaaggc cgccgcgacg actgccgaga cgggggaccc 69300
tgcgccttgg ccgcccgccg gggcccggcc ggtcgatgtc ggcgacgtct acgaacggtt 69360
cgggagtatc gggtacgcat acggttccgc gttccaggga ctgcgcgccg catggcgcga 69420
cggcgacacc gtgcacgccg aggtcgcgct tcccgacgaa cagggcccgg acgcagcccg 69480
gttcacgctg caccccgcgc tgctcgacgc cgcgttccag gccggggcgc tgtccgcgct 69540
cgacgcgccc ggcgaggcgg ccctgctgcc gttctcgttc caggacgtcc ggatccacgc 69600
ggccggggcg acgcgggcgc gggtcaccgt cagccgtgac ggcgatcgca gcaccgtgcg 69660
catgaccggc gaggacggac agccggtggc cgaggtgggc tctgtggtgt cgcgcccgta 69720
cgcgggcggc tccggctccg acgacgagct gctgcgcccg gtctggaccg agctgccgat 69780
gcccgccccg tccgcggccg acccgcgcgt ggaggttctc ggcgcggacc ccctcgacgg 69840
cgaacccgcc gcggcgacac gggagttgac cgcccgcgtc ctcgacgcgc ttcagcaccg 69900
cctgtccgcc accgatgacg tgaccctggt cgtacggatc ggcaccggcc tggccgcggc 69960
cgccaccgcg ggtctggtcc gctccgcgca ggccgagaac cccggccgca tcgtcctcgt 70020
cgaggcgtcc ccggacactc cggcggacct gctcaccgcg tgcgccgccc tggacgaacc 70080
acagttggcc gtccgggacg gtgtgctctt cgcgccgcgg ctggtccgga tgtccgaccc 70140
cgtgcacggt ccgctgcccc tgccggacgg cgactggctg ctcactcact ccgcgtccgg 70200
cgtcctgcac gacgtcacgc tcgccgtcga cggcacacct cgccgggcac tggaagccgg 70260
tgaggtccgc gtcgacgtcc gggccgcggg tctgaacttc cgcgacgtgc tgatcgcgct 70320
cgggacgtac gacggagcca ccgcactggg cggcgaggcc gcgggcatcg tcgtggagac 70380
cgggcccggc gtggccgatc tggcccccgg tgaccgggtg ttcggcctga cccggggcgg 70440
catcggcccg acagccgtca cggaccggcg ctggctggcc cggattcccg acgggtggag 70500
cttcaccacg gcggcatccg tccccatcgt gttcgcgacc gcgtggtacg gcctggtcga 70560
cctcgcgggg ctgcgcgcgg gcgagaaggt cctcgtgcac gcggccaccg gcggtgtcgg 70620
catggccgcc acgcagctcg cccggcacct gggcgccgag gtctatgcca ccgcgggcac 70680
cgggaaacag cacgtcctgc gcgccgccgg gctgcccggc acacacatcg ccgactcgcg 70740
gacgacagcg ttccggaccg acttcccgcg catggacgtc gtcctcaact cgctgaccgg 70800
tgagttcatc gacgcatcac tcgaactcct cgacgcggaa ggacggttcg tcgagatggg 70860
ccgcgccgag ctgcgcgacc cggacacgat cacgcccgcc tacctgccgt tcgacctcat 70920
ggacgcgggc accgaccgca tcggcgagat cctgggcgaa ctcctccagc tgttcgacgc 70980
gggcgccctg accccgctgc cggtccgcgc ctgggacgtc cggcaggcgc gtgacgcgct 71040
cggcgtgatg agccgcgccc gccacatcgg caagaacgtc ctcacgcttc cccggccgct 71100
cgacccggaa ggcgcgatcg tcatcaccgg aggctccggc acgctcgcgg gcatcctcgc 71160
gcgccatgtg agcgggcaac acgtctacct gctgtcccgc acggcaccgc ccgagggaac 71220
gcccggcatc cacctgccct gcgacgtcgg tgaccgccag caactggccg cggccctgcg 71280
ccggatcgac cggccgatca ccgccgtggt gcacaccgcg ggcgcactgg acgacggcac 71340
cctcccgtcg ctcacgcccg agcgcttcga caccgtgctg cgccccaagg ccgacggagc 71400
ctggcacctg cacgaactca cgaaggacca ggacctcgcc gcgttcgtgc tctactcctc 71460
ggccgccgga gtactcggca acgcgggaca gggcaactac gtcgccgcga acgcgttcct 71520
cgacgccctc gccgaacagc gccaggcggc cgggctgccc gcgctctcca tcgcctgggg 71580
gctctgggag gacacgagcg ggctgaccgc cgagctcagc gaggcggaca ggcagcggat 71640
gcggcggagc ggattccgca cgatcagcgc gcgccagggc atgcggctgt acgaggcggc 71700
gaggcgcacc ggaagtcccg tggtggtggc ggccgcgctc gacgacgccc cggacgtgcc 71760
gctgctgcgc gggctgcggc gtacgaccgt ccggcgggcc accgtccggg aacgctccct 71820
ctccgacgag ctcgccgtgc tgcccgacga cgagcgcgcc gacgcgctcc tcgcgttcgt 71880
caggaacagc accgccaccg tgctcggcca cctgggcgcg gaagacatcc cggcgacagc 71940
gacgttcaag gaactcggca tcgactcgct caccgcggtc cagctgcgca acgcgctgac 72000
cacggcgacc ggcgtacgcc tcaacgccac ggcggtcttc gactttccga cgccgcgcgc 72060
gctcgccgcg agactcggcg acgagctggc cggtacccgc gcgcccgtcg cggcccggac 72120
cgcggccacc gcggccgcgc acgacgaacc actggcgatc gtcggcatgg cctgccgcct 72180
gccgggcggg gtcgcgtcgc cggaagggct gtggcgtctc gtcgcgtccg gcaccgacgc 72240
catcacggag ttccccgcgg accgcggctg ggacgtggac gcgctctacg accccgaccc 72300
cgacgcgatc ggcaagacct tcgtccggca cggcggcttc ctcgacggcg cgaccggctt 72360
cgacgccggg ttcttcggga tcagcccgcg cgaggccctg gccatggacc cgcagcaacg 72420
ggtgctcctg gagacgtcct gggaggcgtt cgaaagcgcg ggcatcaccc cggactcggc 72480
ccggggcagc gacaccggcg tgttcatcgg cgcgttctcc tacgggtacg gcacaggggc 72540
ggacaccaac ggcttcggcg cgacaggatc gcagaccagc gtgctctccg gccgcctttc 72600
ctacttctac ggcctggagg ggccgtcggt cacggtcgac accgcctgct cgtcgtcgct 72660
ggtcgccctg catcaggccg gtcagtcgct gcgctcgggc gaatgctcgc tcgccctggt 72720
cggcggcgtc acagtgatgg cgtcgcccgg cggattcgtc gagttctccc ggcagcgcgg 72780
gctcgcgccg gacgggcggg cgaaggcgtt cggcgcgggc gcggacggta cgagcttcgc 72840
cgagggcgcc ggtgccctgg tggtcgagcg gctctccgac gcggagcgcc acggccacac 72900
cgtcctcgcc gtcgtgcgcg gctccgcggt caactccgac ggcgcgtcga acggtctgtc 72960
ggcgccgaac ggcccgtcgc aggaacgcgt catccgccag gcactcgcca acgcgaaact 73020
cacccccgcc gacgtcgacg cggtcgaggc gcacggcacc ggcacccgcc tcggcgaccc 73080
catcgaggcg caggcgctgc tcgcgacgta cgggcaggac cgggcgacgc ccctgctgct 73140
cggctcgctg aagtcgaaca tcgggcacgc ccaggccgcg tcaggggtcg ccgggatcat 73200
caagatggtg caggccatcc ggcacgggga gctgccgccg acgctgcacg cggacgagcc 73260
gtcgccgcac gtcgactgga cggccggtgc cgtcgagctc ctgacgtcgg cccggccgtg 73320
gccggggacc ggtcgcccgc gccgcgccgc cgtctcgtcg ttcggggtga gcggcacgaa 73380
cgcccacatc atccttgagg cgggcccggt caaggcaggt ccggtcgagg caggcccggt 73440
ccccgcggcg ccgccgtcag caccgggcga agaccttccg ctgctggtgt cggcgcggtc 73500
cccggaggca ctcgacgagc agatcgggcg cctgcgcacc tacctcgaca cccgccctgg 73560
cgtcgaccgg gcggccgtgg cacagacatt ggcccggcgc acgcacttcg cccaccgcgc 73620
cgtgctgctc ggtgacaccg tcatcaccac ttccccctcg caccaggccg acgaactcgt 73680
cttcgtctac tccggtcagg gcacccagca tcccgcgatg ggcgagcaac tcgccgccgc 73740
cttccccgtg ttcgccgaga cctggcacga cgcgctccgg cggctcgacg accccgaccc 73800
gcacgacccc acacggagcc agcacacgct cttcgcccac caggcggcgc tcaccgccct 73860
cctgaggtcc tgggacatca cgccgcacgc cgtcatcggc cattcgctcg gcgagatcac 73920
cgccgcgtac gccgccggga tcctgtcgct cgacgacgcc tgcaccctga tcaccacgcg 73980
cgcccgcctc atgcacacgc ttccgccgcc cggcgccatg gtcaccgtgc tgaccggcga 74040
ggaggaggcc cgtcaggccc tgcggccggg cgtggagatc gccgcagtca acggcgccca 74100
ttccgtcgta ctttcgggcg acgaggacgc cgtgctcgat gtcgcacagc ggctcggcat 74160
ccaccaccgc ctgcccgcgc cgcacgccgg tcactccgcg cacatggagc ccgtggccgc 74220
cgagctgctc gccaccaccc gtcggctccg ctacgaccgg ccccacaccg ccattccgaa 74280
cgaccccacc accgccgagt actgggccga acaggtccgc aaccccgtgc tgttccacgc 74340
ccacacccag cagtaccccg acgccgtgtt cgtcgagatc ggccccggcc aggacctctc 74400
accgctcgtc gacggcatcg cgctgcagaa cggcccggcg aacgaggcgc acgcgctgcg 74460
caccgcgctc gcccgcctct tctcgcgcgg cgccacgctc gactggcccc tcgtgctcgg 74520
cggtgcttcg cggcacgacc cggacgtccc ctcgtacgcg ttccagcagc ggccctactg 74580
gatcgagtcg gctcccccgg ccacggccga cgcgggccac cccgtcctcg gcaccggagt 74640
cgccgtcgcc gggtcaccgg gccgggtgtt cacgggtccc gtgccgaccg gtgcggaccg 74700
cgcggtgttc atcgccgaac tggccctcgc cgccgccgac gccaccgact gcgcgacggt 74760
cgaacagctc gacatcacct ccgtgcccgg cgggtccgcc cgcggcaggg ccatcgcgca 74820
gacctgggtc gatgaacccg cggccgacgg gcggcgccgg ttcaccgtgc actcccgggt 74880
cggcgacgct ccgtggacgc tgcacgccga gggggttctc cgccccggcg gcgtgccccg 74940
gcccgacgcc gtcgacgccg cctggccccc gccgggcgcg gtgcccgcgg acggtctttc 75000
cagggcgtgg cgacgcgcgg accaggtctt cgtcgaggcc gaagtcgaca gccccgacgg 75060
cttcgtggca caccccgacc tgctcgacgc ggtcttctcc gcggtcggcg acgggagccg 75120
ccagccgacc ggctggcgcg acctcgcggt gcacgcgtcg gacgccaccg tgctgcgcgc 75180
ctgcctcacc cgccgcgccg gtggtgtcgt ggaactcgcc gccttcgacg gcgccggtct 75240
gccggtgctc accgcggagt cggtgacgct gggcgaggtc gcgtcggcag gcggatccga 75300
cgagtcggac ggtctgcttc ggcttgagtg gttgccggtg gcggaggccc actacgacgg 75360
tgccgacagc ctgcccgagg gctacaccct catcaccgcc acacaccccg acgaccccga 75420
agacgacccc accaaccccc acagcacacc cacacgcacc cacacacaaa ccacacgcgt 75480
cctggccgcc ctccaacacc acctcaccac caccaaccac accctcatca tccacaccac 75540
caccgacccc ccaggcgccg ccgtcaccgg cctcacccgc accgcacaaa acgaacaccc 75600
aggccgcatc cacctcatag aaacccacca cccccacacc ccactccccc tcacccaact 75660
caccaccctc aaccaacccc acctacgcct caccaacaac accctccaca ccccccacct 75720
caccccactc acctccaccg gcaaccccaa cccccaccac cccacaacac ccaccccacc 75780
cctcaacccc gaccacgcca tcctcatcac cggcggatcc ggcaccctcg ccggaatcct 75840
cgcccgccac ctcaaccacc cccacaccta cctcctctcc cgcaccccac caccccccac 75900
cacacccggc acccacatcc cctgcgacct caccgacccc acccaaatca cccacgccct 75960
caaccagata ccccaacccc tcaccggcat cttccacacc gccgccaccc tcgacgacac 76020
ccccctccac accctcaccc cccaacgcct caccaccgtc ctccaaccca aagccgacgc 76080
cgcctggcac ctccaccacc acacccaaaa ccaacccctc acccacttcg tcctctactc 76140
cagcgccgcc gccaccctcg gcagccccgg ccaagccaac tacgccgccg ccaacgcctt 76200
cctcgacgcc ctcgccaccc accgccacac ccacaaccaa cccgccacca ccatcgcctg 76260
gggcatgtgg cacaccacca ccacactcac cgcacacctc accgacagcg accgcgaccg 76320
catccggcgc ggcggtttcc tgccgatctc ggacgacgag ggcatgcgcc tctacgacgc 76380
ggccgtcggc tcgggcgagg actacgtact ggccgcctcg atggacccgg cgcagccgat 76440
gtcgggcgac gtaccgccga tcctcagcgg tctgcgcaga agcgcgcgcc gcaccgcccg 76500
gaccgggcag acgttcgcgc agcgcctcgc cgaactgccc gacgccgacc gcgacacggc 76560
gttgagcacc ctcgtcatgg atgccacggc cgccgtgctc ggccacgccg acgcctccga 76620
gatcgggccc acgaccacgt tcaaggacct cggcatcgac tcgctcaccg cgatcgagct 76680
gcgcaaccgg ctcgcggagg caaccgggct ccggctgagc gccacgatgg tgttcgacca 76740
tccgacaccg cgggtactcg ccgccaagct ccgcaccgac ctgttcggca cggccgtacc 76800
tacgcccacg cggacgaccc gggcccgtca cgacgagccc ctcgcgatcg tcggcatggc 76860
ctgccgcctg cccggcggcg tgacctcacc cgaggacctg tggcggctcg tggcgtccgg 76920
cacggatgcg atcaccgagt tccccaccga ccgcggctgg gacatcgacc ggatgtttga 76980
cccggacccg gacgcgcccg gcaagaccta cgtccggcac ggcggtttcc tctccgaggc 77040
ggccgggttc gacgccgcgt tcttcggcat cagcccgcgc gaggcatggg ccatggaccc 77100
gcagcagcgc gtcatcctcg aaaccgtatg ggaagcgttc gagaacgccg gaatcgtgcc 77160
ggacaccctg cgcggaagcg acaccggcgt gttcatgggc gcgttctccc acgggtacgg 77220
cgcgggcgtc gacctgggcg ggttcggcgc cacggccacc cagaacagcg tgctctccgg 77280
ccgcctctcg tacttcttcg gcatggaagg cccggccgtc accatcgaca cggcgtgctc 77340
gtcgtccatg gtcgcgctgc accaggcggc gcagtccctg cgggacggcg aatgctcgct 77400
ggcactcgcg ggtggcgtca cggtgatgcc cacaccgctc ggctacgtcg agttctgccg 77460
ccagcgcggg ctcgccccca acggccgggc caaggccttc gcggagggcg ccgacggtac 77520
gagcttctcc gaaggcgccg gtgttctcgt cgtcgagagg ctctccgacg ccgagcgcaa 77580
cggtcacacg gtcctcgcgc tcgtccgctc ctccgccgtc aaccaggacg gtgcctccaa 77640
cggcatctcc gcgcccaacg gcccgtcgca gcagcgcgtg atccgccagg cactcgacaa 77700
ggccggactc actcccgccg acgtggacgt ggtggaggcg cacggcaccg gcacacctct 77760
gggcgacccg atcgaggcgc aggccatcat cgcgacgtac gggcaggacc gcgacacacc 77820
gctctacctc ggttcggtca agtcgaacat cggccacacc cagaccaccg ccggtctcgc 77880
gggtgtcatc aagatggtga tggcgatgcg gcacgggttg ctcccgaaga cactccatgt 77940
ggacgagccg tcgtcacatg tggactggtc ggcaggggcg gttgagctgc tcacggaggc 78000
gaggccgtgg ccggactcgg accgcccgcg ccgggcaggt gtgtcatcgc tcggcatcag 78060
cggcacgaat gcgcatgtga ttttggaggg ggttgcggag tcgtcggttc gtagcggggg 78120
gtcgtcgggt ctggtgccgt tgccggtgtc ggcgcgtacg gagtcgagct tggcgttgca 78180
ggtggagcgg gtcggcgagt atgtgcgggg tggggcggac ctgggcgcgg tggcggatgg 78240
tctggtgcgt gggcgtgcgg tgttcgaccg tcgggcggtg ttgctcgggg agagcacggt 78300
cgccggagtc gctgtggagg gggcgcggac ggtgttcgtg ttcccggggc agggctcgca 78360
gtgggtgggc atgggccggg agttgatggg cgcctcggag gtgttcgcgg cgcggatgcg 78420
ggagtgtgcg gcggcgttgg agccgcatac cggttgggat gtgctggatg tgctgggtga 78480
ggcggtggtg gctgatcggg tggaggtgtt gcagcccgcg tcgtgggcgg tggcggtgag 78540
cctggccgca ctgtggcagg cccacggcgt ggtgccggat gcggtgatcg ggcattcgca 78600
gggggagatc gccgcggcat gtgtggcggg agccttgagt ctggaggacg ccgcgcgggt 78660
cgtggccttg cgcagccaga ccatcgctgc gcggctggcc gggcacgggg cgatggcatc 78720
aatcgccctg cccgccagcg ccgttgaggt agcggagggc gtgtggatcg ccgcgcgcaa 78780
cggtccggaa tccaccgtgg tcgcgggcga tccgggcgcg gtggagcggg tgctggcccg 78840
gtatgaggct gcgggtgtgc gggtgcgccg gatcgcggtg gattacgcct cgcacacccc 78900
gcacgtggaa gcgatcgagg agcaactcgc cgacgtctta gggggaatca ccagcagcgc 78960
acctgacatc tcctggtggt cgacggtgga cagcggctgg gtgaccgaac cggtcggtga 79020
cgactactgg taccgcaacc tgcgtcagcc cgtcgcgatg gacaccgcga tcagtgagct 79080
ggacggctcg ctgttcatcg agtgcagcgc ccacccggtg ctgctgcccg ccctcgacca 79140
ggaacacacc gtcgcctccc tgcgcaccga cgacggcgac tgggaccggt tcctgaccgc 79200
cctcgcacag gcctggaccc agggcgcacc cgtcgactgg accaccctga tcgagcccgc 79260
cccgcaccgc ctgttggacc tgcccaccta ccccttcgac cacaagcggt actggataga 79320
ggcggccagc gcaaccgacc tcaccgccct cggtctcacc gacaccgcac accccatgct 79380
ggcggcgacc gccgcgctgc ccacgaacga cggcaccgta ctcaccggcc ggatctccct 79440
gcgtacccat ccctggctgg ccgaccacgc catccaggac tcggtgttgc tgccgggcac 79500
agcgttcctc gaactcgtgg tgcgggccgg agacgaggtc ggctgcgaca ccatcgacga 79560
actggtcatc gagaccccgc tcgtactgcc cgtcaccggt gccgtcgacc tcaccgtcac 79620
cgtcgaccag cccgacacca ccggccaccg cccggtgagc gtccacgcac gccccgaagg 79680
aaccgacacc tggacccgcc acgccaccgg cacactcacc accagcgcca ccgacaccac 79740
ccccgccccg agctccttcc cgcaatggcc gccaaccagc gcctctgcca tcgacatcac 79800
ggagttctac gcccaactgg ccgtgctggg ctaccggttc ggccccacgt tccgcggact 79860
gcgggcagcg tggcgtgacg gtgacaccgt gtacgccgag gtggcgctgc ccgaggaccg 79920
tgccgccgac gcggaccgct tcggcgtaca cccggccctg ctcgacgccg cgttgcagag 79980
cggcagtctg ctcatgctgg catcggacgg cgagcagggc gtgcaactgc cgttctcctg 80040
gcacggcgtc cggttccacg cgaccggggc gacctcactg cgggtgacga tcgtgcccgg 80100
ccccgacggc ctccggctcc gcgccgccga cagcgagaac caccccgtcg cgaccatcga 80160
cgcactggtc acccggcctc ctgccgacct cgcacccgcc gaccctgtgc tgcgggtcgg 80220
gtggaccgcg gtgcccgtac ctgccgaggt cagcccgtcc gacgcggacg tactgacact 80280
gcacagcgac gatgccgatc cggtccagga aacccgggaa ctcaccactc gcgtgctcga 80340
cgcgctgctg gaggtcgagc ggaccctgat cgtccaggtc accggcggtc ttgccgcgat 80400
ggcggccgcg ggcctggtcc gcaccgctca gagcgagcag cccggccgtt tcttcctcgt 80460
cgagacggac cccggagagg tcttggacag cgcgcggtgc gacacgatcg cggcgctcgg 80520
cgagccccgg ctgcggcttc gcgacaaccg gttcgaggca gcccggctgg tgcgcgccac 80580
acccgccctg acgcctccgg acaccgggtc gtggcagctg cggcagtccg ccaccggctc 80640
gctcgacgac ctcgccctcg tgcccaccga cgagcccgac cggccgctcg cagccggtga 80700
ggtgcggatc gcggtacgtg cggcgggcct gaacttccgc gacgtcacgg tcgccctcgg 80760
cgtggtcgcc gatgaccgcc cgctcggcag cgaagccgcc ggtgtcgtcc tggagaccgg 80820
tcccggcgtg cacgacctgg cgccgggcga ccgggtcctg gggatgctcg ctggcgcgtt 80880
cgggccggtc gcgatcactg accgtcggct gctgggccga gtgccggagg gttggacgtt 80940
tccgcaggcg gcgtcggtgg tgacggtgtt cgcgaccgcc tggtacggcc tggtcgacct 81000
ggccgagctg cgcaccggcg agaaggtcct gatccacgcg gcggccaccg gagtcggcgc 81060
ggccgccctc cagatcgccc gccacctggg cgcggacgtg tacgccaccg ccagcacccc 81120
caaacagcac ctggtggacc tggcacccac ccacatcgcc gactcccgca gcaccgcctt 81180
cgccgacacc ttccccccgg ccgacgtcgt cctcaactcc ctcaccggcg aactcctcga 81240
cgcctccacc gcactcctca cacccggcgg ccggttcatc gaaatgggca agaccgacat 81300
ccgccaccac gcccaacagc ccttcgacct catggacgca ggacccgacc gactccagca 81360
gatcatcacc caactcctcg acctgttcgc caacggcaca ctgcaccccc taccggtcca 81420
cgcctgggac gtacgacagg cgcgggaggc gttcggctgg atgagcagcg gtcggcacac 81480
gggcaagctg gtactcacgg tcccgcgacc gctcgacccc gagggcgccg tcatcatcac 81540
cggcggctcc ggcaccctcg ccggaatcct cgcccgccac ctcaaccacc cccacaccta 81600
cctcctctcc cgcacacccc cgcccgacac cacccccggc acccacctgc gctgcgacgt 81660
cagcgacccc acccaactcg ccaccgccct cgcccagata ccccaacccc tcaccggcat 81720
cttccacacc gccgccaccc tcgacgacgc cctcctcgac aacctcacac cccaacgcat 81780
cgacaccgtc ctcaaaccca aagccgacgc cgcctggcac ctccaccacc aaacccgcca 81840
caccgacctc accgcattcg tcctctactc cgcggtcgcc ggtgtcatgg gcagtcccgg 81900
ccagggcaac tacgtagcgg cgaacgcgtt cctcgacgca ctcgccgaac accggcaggc 81960
gaggggactg cccgcgcagt cgctcgcgtg gggcatgtgg gcggacgtca gcgcactcac 82020
cgcgaaactc accgatgccg accgcgaacg catccggcgc agcggattcc cgccgttgag 82080
cgcggcggac ggcatgcggc ttttcgactc ggcggcgcgt acgccggagc cggtcgtcgt 82140
cgccacgacc gtcgacgtca cccggctcga cggcccggtc gcgccgctgc tccgcggcct 82200
ggtggcccac cggtcagggc cggtgcgagc ggtcgcccgc aacgccgacg acgagccgct 82260
cgcggcacgt ctcgccgggc acaccgccgc cgagcagcgg cgcgtgatgc aggaggtcgt 82320
gctccgtcag gcggccgcgg tgctcgcgta cggcctgggc gaacaggtcg cggcggaccg 82380
gccgttccgc gatctcggct tcgactcgct gaccgcggtc gacctgcgca accggctcgc 82440
ggccgagacg gggcttcggc tgccgacgac cgtggtgttc agccacccga cggcggaggc 82500
actcgccacg cacctgctcg aactgctcga cgctcctgcc gccctgaccg ccggggcgtc 82560
cctgcccgcg gtgacggccg cgcccggcac ggccgcgcgg gatcaggacg agccgatcgc 82620
gatcgtggcg atggcgtgcc gcctgcccgg cggcgtgacg tcaccggagg agctgtggcg 82680
gctcgtcgag tccggcaccg acgcgatcac catggcgccc ggcgaccggg gctgggacct 82740
cgacgcgctg tacgacccgg acccggacgc ggtgggcaag gcgtacaacc tgcggggcgg 82800
attcctggag ggggcggcgg agttcgacgc ggcgttcttc gacatcagcc cgcgggaatc 82860
gctcggcatg gatccgcagc agcgcctgct gctcgaaacg gcgtgggagg cgatcgagcg 82920
cggccggatc aaccccgcgt cgctgcacgg ccgggagatc ggtgtgtatg tgggtgccgc 82980
cgcgcagggc tacggtctcg gcgccgagga caccgagggc aacgcgatca ccggcggctc 83040
cacgagcctg ctgtccgggc ggctcgcgta cgttctcggg ctcgagggcc cgtccgtcac 83100
cgtcgacacg gcgtgctcgt cgtcgctggt cgcactgcac ctcgcatgtc aggggctgcg 83160
cctcggcgag tgcgagctcg cgctggccgg tggcgtttcg gtgctgagct caccggccgc 83220
gttcgtcgag ttctcccgcc agcgcggtct cgcggccgac gggcgctgca agtcgttcgg 83280
ttcgggcgcg gacggcacga cgtgggccga gggcgtgggt gtcctcgtcc tcgaacggct 83340
ctccgacgcc gagcggctcg gccacaccgt gctcgccgtc gtccgcggca gcgccgtcac 83400
gtccgacggc gcctcgaacg ggctcaccgc gccgaacggg ctcgcgcagc agcgggtcat 83460
ccgcaaggcg ctcgccgcgg ccggactgac cgccgccgac gtggacctcg tcgagggaca 83520
cggcacgggc acccggctcg gcgaccccgt cgaggcggac gcgctgctcg cgacgtacgg 83580
gcagaaccgc caggagccgg tctggctggg ctcgctgaag tcgaacatcg ggcatgcgac 83640
ggccgcggcc ggtgtcgcgg gcgtcatcaa gacggtgcag gcgatcggcg cgggcacgat 83700
gccgcggacg ctgcacgcgg acgagccctc gcccgccgtc gactggaccg ccgggcgggt 83760
gtcactgctc accggcaacc ggccctggcc ggacgacgag cgtgcccggc gagcagcagt 83820
ctccgcgttc gggctcagcg ggacgaacgc tcacgtcatc ctcgaacagc accggccgga 83880
gcccgtggcg ccgcgaccgc ctcgcgagga acctcggccg ctgccctggg tgctgtccgc 83940
gcggacccct gccgcgctgc gggcgcaggc cgcccggctg cgcgatcacc tggcggccgt 84000
gccggacgcg gacccgttgg acatcggata cgcgctggcc accagccgcg cccggttcac 84060
acaccgggcc gcggtagtgg ccacttcctc tgacgagttc cgcgccgggc tcgacagcgt 84120
cgcggacggc gtcgaagcgc ccggagtcgt cggcggaacc gctcgggagc ggcgcgtcgc 84180
cttcctcttc gacgggcagg gcgcccagcg cgtcggcatg gggcgcgaac tccacgggcg 84240
tttccctgtc ttcgccgccg cgtgggacga ggtgtccgac gcgttcggca agcacctgga 84300
gcactccccc acggacgtct tccacggcga gcacggtgat ctcgcccatg acaccttgta 84360
cgcccaggtc ggcctgttca cgctcgaagt ggcgctgctg cggctcctcg agcactgggg 84420
tgtgcgtcct gacgtgctcg tcgggcactc cgtcggcgag gtcaccgcgg cgtacgcggc 84480
gggcgtgctc acgctggcgg acgcgacggc gttgatcgtg gcccgtgggc gggcgttgcg 84540
ggcgctgccg ccgggagcga tgaccgcggt cgacggaagc ccggcggagg tcggcgcgtt 84600
caccggtctg gacatcgccg cggtcaacgg cccgtccgcc gtggtgctca cgggttcacc 84660
ggacgacgtg accgcgttcg aacgggagtg ggcggcggcc gggcggcgcg cgaaacggct 84720
cgacgtcggg cacgcgttcc actcccggca cgtcgacggc gcgctcgacg acttccgtac 84780
ggtcctcgaa tcgctctcgt tcggcgcggc ccggctgccg gtggtgtcca cgacgacggg 84840
ccgggacgcc gcgggcgacc tcgcgacgcc ggagcactgg ctgcgtcatg cgcgccgtcc 84900
cgtgctgttc gcggacgccg tccgggagct cgccgacctc ggcgtgaaca tgttcgtggc 84960
cgtcggtcct tccggggcac tcgcgtcggc cgcgtcggag aacaccggcg ggagcgccgg 85020
gacgtaccac gcggtgctgc gcgcccggac cggcgaggag aacgcggcgc tgaccgccgt 85080
cgccgaactg cacgcccacg gcgccccggt ggacctcgcc gcggttctgg cgggcggacg 85140
cccggtggac cttcccgtgt acccgttcca gcaccgctcc tactggctgg cccctgccgt 85200
gggaggtggt tcgccgaccg ccgtgccgga caccgggcgg ccggcggagc ccgaccctga 85260
cgacctcacc gtcgccgaga tcgtccggcg gcgtgccgcg gcactgctcg gcatcgccga 85320
ccccggcgac gtcgacgcgg acacgacctt cttcgcgctc gggttcgact ccctcgccgt 85380
ccagcggctg cgcaatcagc tcacggcggc gaccggcctc gacctgccca cggccgtcct 85440
gttcgaccac gacaccccgt ccgccctcac cgcttatctg gaggagcagc tcggcgacgg 85500
cgcggacgac gacgcaccca ccgtgctcgc gctcctggcg gagatggagt cgctcgacgc 85560
cgcggacatc gcggcgacac cggccccgga gcgtgcggcc atcgccgatc tgctcgacaa 85620
gctctcccgt acctggaagg accaccgatg agccccgaca cgcacgacga gacgacggcc 85680
accagccggt gcccgttcgc gatccaggac gcccaccggg cgatcctgga gagcggcacg 85740
gtcggctcgt tcgatctgtt cggcatcaag cactggctgg tcgccgccgc cgaggacgtc 85800
aagctggtca ccaacgaccc gcggttcagc tcggccgctc cgtccgagat gctgcccgac 85860
cggcgtcccg gttggttctc cggcatggac ctgccggagc acagtcgcta ccggcagaag 85920
atcgccgggg acttcacgct gcgcgccgcg cgcaagcagg aggacttcgt cgtcgaggcc 85980
gcggactcct gtctggacga catcgaagtc gccggtcccg gcaccgacct gatccccggg 86040
tacgcgaagc ggctcccctc cctcgtcatc aacgcgttgt acgggctcac ccttgaggag 86100
ggcgaggtac tcgaggcgcg catgcgcggc atcacgggct cggtcgacct ggacagcgtc 86160
aagacgctga ccgacgactt cttcgcccac gcgctggagc tggtccgcgc caagcgtgac 86220
gagcagggcg acgacctgct gcacaggctc gcctcgacct cggacggtga gatctcgctg 86280
agcgacgacg aggcgacggg cgtgttcgcg acgctgctgt tcgccgggca cgactcggtg 86340
cagcagatgg tcggttacag cctctacgcg ctgctcagcc accccgagca gcaggcggcg 86400
ctgcgcgcgc gaccggagct gatcgacaac gcggtcgagg agatgctgcg cttccttccg 86460
gtcaaccaaa tgggggtgcc gcgcgtctgc gtcggggaca tcgacctaca gggtgtgcgg 86520
atcagtgcgg gcgacaacgt gatcccgctc tattcgacgg cgaaccgcga cgcggcggtg 86580
ttcccggacc ccgatgcctt cgacgtgacg cgtccgccgg aggggaactt cgcgttcggc 86640
cacggcatcc acaagtgtcc gggccagcac gtcgcccggc tgctcatcaa ggtcgcctgc 86700
ctgcggttgt tcgagcggtt cccggacatc cgcctcaccg gtgacgtgcc gatgaacgag 86760
ggcctcgggc tcttcagccc ggccgagctg cgggtcacct ggggtaccga gtgagcgcgg 86820
cggtggagac gttgcggctg ccgaacggga cgacggtcgc gcacatcaac gcgggcgagg 86880
cgcagttcct gtaccgggag atcttcaccg agcgctgcta tctgcgccac ggcgtggaac 86940
tgcgccctgg gggtggtgtt cgacatcggc gcgaacatcg gcatgttcac gctcttcgct 87000
catctcgagc gtcccggcgt gaccgtgcac gcgttcgagc ccgcgccggt gccgttcgcc 87060
gcgctgcggg cgaacgcggc acagtacggc atctcgggcc gggtggacca gtgcgcggtc 87120
tccgacgaga ccggcgtgcg caagatgacg ttctaccccg acgccacgct gatgtccggc 87180
ttccacccgg acgccgcggc ccgtaaggag ctgttgcgca ctcttggtct caacggcgga 87240
tacaccgccg aggacgtcga cggcatgctg gcccaactgc ccgattcggg cgaggagatc 87300
gagaccgccg ttgtccgcct ctccgacgtc atcgccgagc gccgcatcgc gacgatcggc 87360
ctcctgaagg tcgatgtgga gaggagtgaa cggcaggtcc tcgccggtgt cgacgaggcc 87420
gactggcccc gcatccgcca ggtcgtcgcg gaggtccacg acgtggaggg cgcgctcgac 87480
gaggtcgtcg cactgctgcg cggccatggc ttcaccgtcg tcgccgagca ggatccgctg 87540
ttcgtcggca cggacatcca ccaggtcgcc gcgcggcgtg ggacccactg agcggccggg 87600
gcggggctac ccgcaccggc ggtcgcggtc cgccggctcg ccgacgtcgg ccagttcctt 87660
cggaagctgc tggcggccct tcaccgccag tttgcggaac acgttcgtga ggtgctgttc 87720
caccgtgctg gccgtgacga acagctgctc ggcgatctcc ctgttcgtac gcccgaccgc 87780
ggcgagcgcg gccacccgcc gctccgactc cgtcagtgac gcgatccgct gtcccagcgt 87840
cgcgtcccag gctccgccga tgtccgaggg ttccgcgccg agccgccgca ggagcggcac 87900
ggcgccgcac tgggtggcga ggtgccgtgc ccggcggagc agaccccgcg ccctgctgtg 87960
ctgccggacc atgctggagg cctctgccaa gtcgctgagt acgtttgcca gttcgtactg 88020
gtcgttgcag gtgaccagca ggtcggcggc ctcttcgagc aggtcgatcc gttggggcgg 88080
cggactgtag gccgcctgta cccgtaacgt ctgcacgcgc gcgcgagggc gcatcggccg 88140
ggacagctgc tcggagacga gccgcagtcc ttcggcacgg tcacggccga gcagcagcag 88200
cgattcggcg gcgtcgaccc gccacagggc caggcccggc acgtcgacgg cccaccgccg 88260
catccgctcg ccgcattccc tgaacgccgt gtacgccgcc ccgtgccgcc cggtcgcgag 88320
gtggtgctgc ccgcgggccc agagcaggtg cagcccgaag aggctctccg gcgtctgctg 88380
cggcagcggc tcggcgagcc accgctcggc cctgtcgagg tcgccgagcc ggatcgcggc 88440
aaccacggtg ctgctcagcg gcagagcggc ggccattccc caggtgggca ggtgccggtg 88500
gccgagcgct gcctcgccgt actcgacggc tctcatcaag tcgccgcggc gcagcgcgat 88560
ctcggcgttg aaccccgcgt ggaccgcctc gtcggccggt gtcctggtgc cctcgtcacc 88620
ggccagtttg tcgacccaga actggacagc atcggtgttc tccgcgtaga gcagggccag 88680
caacgccatg atggccgtgg tccggtccgc cgtggcgtcg gtgtgctgga gaacgctctc 88740
cgcgttggcg tccgcccggt cgagacgtcc acgcagcgcc gcgatgacgg cttggtcggc 88800
gaccgcgcgg tgccgggcgg gtccgggaag cgagccgagc ccgcccgcgg cgaaccgatc 88860
ggtccggcgc aacggatccc acgcgccggg gtggaccagc gcgagggaca actcgccgct 88920
gcgcaggagt gcgcggtgct gctcgctgtc ggccgcggga cgctgcgtcg cgaggacctc 88980
ggccgcctcg cccgggcgcc cgcccatcgc cagccagtcg gcgagcgaca cggcgtgctc 89040
gctggagagc agtcccgcgc gcgacgcggt gagcagctcg ggcagatgcc ggcctgcccg 89100
taccggattg cagaggcgct cgatcgcggc ggcgccgacg cgtagtgcgg cgcgcgtgac 89160
ggggtcgtcg gaggcacggt gggcgagttc caggtatccg gccgcgtcgt ccagttcacc 89220
gcgcaggtgg tgctcccgtg cggccccggt gaacagctcg acggcctcct cgccgtgcac 89280
ccggccggcg ccgatctggt ggcgggcgag cacgttgccg gccacgccgt ggtcccgcag 89340
cagctccagc gccgactcgt gcaggtttct gcgttccagg gccgacaggt cgtcaaggac 89400
gatggagcgg gccgccgggt gcggaaaccg ctcgccctgc agcagccgtc cctcgttcag 89460
ctgctcatag acctgttcga ccgcgtcctt gttcagtccg gtcatccgct ggacgagcac 89520
ggcttcggcg ctcgcgccga gcacggcgga cgcccgggcg acacgcagcg cgctcgggcc 89580
gcagcggtag agcgagctga ggtacgcgag ccggtacgcc cgccccgcga cgacccccgg 89640
ccgtcccgct gtccgcgcct cccggatgtc attgatcaaa ccgtgcccga ggagcaggtt 89700
cccgccggtc gcccggaacg tatcggcgga gacgtcctcg tgggtctccg cgccgaggtg 89760
ccgacgtacg agttcgccgg tctgcgcctc ggtgagcggt ctgagcgcga tctcctggta 89820
ggagcgcagg ctcagcagtt ccgcctggaa gcgggagtcg gcgggcgtcg gtctgcgcag 89880
ctcggtcagt acgaccgcga tgcgggccgg gccgatgcgg cgggcgaggt ggagcagaca 89940
gcgcagtgat tccgcgtcgg cgtggtgcac gtcgtcgatg ccgatcagga cgggccagtc 90000
cgcggcgagc gccagcaggg tgcgggtgaa ctcggcccgc aggcggttgt cggtaccggc 90060
ctgagggctc tcgcacgaag ccgtgaagtg ggcaaggtcc ggcgcctggg cggccagttc 90120
gggatggtcg aagagctggc ccagcatccc gtacggcaga gtgcgctctt cccaggagca 90180
caccgcacgg agtgcgacga agccggactt ggccgctccg gcgtcgagca gcgccgtctt 90240
tccgctggcg atgggcccgg tgatggcgac gacgccgccc cttccgctcc ccgccctggt 90300
gagtgcccgt tggaggcggc tcagctcgtc atcgcgggcg atcagttcgt cgggggctgc 90360
tcgcacttca ggaaccacct cgcggccatc ttctaaatcg gtcggcgcca tgcaaaattc 90420
tttagcatat gcggctgtca atggtgttac cggatggcat gatctgcctc ttccgtggct 90480
ccgccccgcg gcgccgcgag ccgtacgcct cgcgccaccg tctcggccac ccgctcctgg 90540
tgctcgacga ggtagaagtg cccgcccggg aagacctcca cggccgtcgg cgcggtggtg 90600
tgaccggccc aggcacgggc ctgctccacc gtcgtcttcg gatcgctgtc gccgatgcac 90660
accgtgatcg gcgtgtccag cggcggcgcg ggctcccacc ggtacgtctc cgccgcgtag 90720
tagtccgcgc gcagcggcgg caggaccagc gcacgcagtt cgtcgtccgc cagtacgtcg 90780
gcgctcgtgc cgccgagtcc gaccaccgcc gccagcaact cgtcgtccga cgccagatgg 90840
acggtgtcgg tgagcgcacg cgacggcgca cgcccgcccg acacgatcag gtgcgccacc 90900
gggacccgcc gcgccagctc gaacgcgagc gtcgcaccca tgctgtgacc gaacaacacc 90960
aacggccggt cgagacccgg ctccagcgcc tgcgccacga gcccggcaag ggaacgcagg 91020
tcccgcagcg gctcctcgtc ccgacggtcc tgacggccgg gatactgcac ggcatacacg 91080
tccgccaccg gggcgagcgc gcgggcgagc ggcagataga aggtcgccga ccctccggag 91140
tggggcaaca gcaccacccg tacggcagcg tcaggcgtcg ggaagaactg gcgtaaccag 91200
agatcctctt tcatctcgca cccccggcgg gcacttgagg catcggaccg tgggcaccgg 91260
acgtcgcgcg ccccgactgc tggaaaacga tgtcgggctc cacgacggcg tgaccggtac 91320
gccgtacgaa gccggtcctg ccgtaccggg ccaggaacgc gagcgtggga aatggctgga 91380
agctctcgct ccacatggtg ccgccgtcga ccgaactcac tttccgaacg cccggcacct 91440
ctccgggcac gggctcggac ggcggcacgt cgagcacgtg cgccaccctc tcggaccgct 91500
tgtcctgact ccgcttgcct acgcacaact ccatctcgtc ggcgagcacc acggctccct 91560
gacagctctc aaaatcgcgc atgccgacct ccactcccaa gatggcaaat cgaccctaac 91620
gatgctggtg acggccgtga cacccctgac cgaaaccacc accccccagc acggcggctg 91680
ggggcacttg acagctcccg ccgagcacca cccagatgac gcttcaatca gattccgtca 91740
ccctccgctc ctcaccggct gaacgggact gtcccccgcc tgtcgttgat gaggtcagcc 91800
ggaatcagaa ggcgggcgct ctcggcacgc agggagccgg cggggctgag gggtccaggg 91860
ctcgtttgac gagtccgatc gcacgcgggc tgtacgacat gctcagatgg gcggagaggt 91920
cgacggagca gccctcctgc aaggtgatgt tccgcaccgt cgctccgggg cccgccgtca 91980
tgaacgtgct ctgccagggg gtggtgatct cgtcgtactt cgtgccgatc acggtgtagt 92040
cgaccccggg aacggtgtcg ccgtcggcgt tgagctcttt gatgaagtcg gacttcacgt 92100
actgctggac gcccgccttc ccgaggggct tctccccgga tttcagtatg tggagcgcgt 92160
cggcgagtgt cgtgaagccg ctcatggtgg tgccgtggtt ggtcgcgccg agttggacga 92220
tcttcttgac cttgttcttc gaggggtcgc tcgtgttcgc gcctccgtcg gccttgaggt 92280
accagcgggc cagggtcccg ccctgggaat gaccgacaag gtccacctgg ccggagccgc 92340
tggcggcgag caccttgtcc acgaaggcgg ccagctcctt ggaggactcc ttgatgtctc 92400
cgtagccctt gacggtggga gcgagagcca ctccggcgtc gtcggtgtcg ccgaagtcga 92460
gggcgtagac gcagtagccc tgggccttca actcggggga catccgggcc cagttgttgt 92520
agcggttctc gtaggtgccg tgtaccagga cgaccggccg cgggtgggcg gcgctgggac 92580
ggcaggtcca gtcgttggcg ccgggcgggt cgatgtcgag gcgaaggatg gaatggacca 92640
tggcaggaaa gaagttgtcc tgctcaggcc ggtctccgcg gccgcggacg tggaagtgac 92700
caagaccgtc gctgcggcgg cggcacagac ggcggtgacg tatctgggta tgtgcaagac 92760
ggctcctgag aagtgtggaa ctcgggccca cgcgcgatgt cggctcgtcg gcactcagca 92820
tggccgcgac gctatcgacc cgcccgcgat ctccacaccg tttctccgag atcagtccag 92880
atcagaggct aaccggggac gtctggcaca tggggaagcg cttcatgcat caccgcacca 92940
ccccggcggt cgcctccgcg gcggactgcg tcgacgtgaa gcaaccctca ggagggggca 93000
tctgccctcc agcaagcgcc gtagagtccg gccaactcgg cggtggcgca ggccaactcc 93060
gtacgggcct cggaaacagg tggcgcggtg aagtacccac cggcgatatg ggtcaccatg 93120
tccagccgct cgcggctcag ccggacggtg accctgatgc cgacgctgcg gtcttccacc 93180
tcgcggcgca gatcgtgcca gacctgggcc agctccacgc cggggcggcg gcgcgcctcg 93240
gcctcgatga cgctgacctg cgacagccgg tcggttcgca ggagcagcgg ggtgcccttg 93300
tgatcggcga ccagctacca ggtaccggcc ttggccacga ggccgtacgg gtcgacggtg 93360
taggggcgcg gcgcggcatg ccagcggtcg ggttcgacga ggatgcggcg gctggtcagc 93420
tcgtccgccg gtcgcatcag ttcggctcgt ggccgtgatc ggggtcgcgt gggtggcggc 93480
gagcgtcgcc tccctcgtcc tcgactggtg ggaccccaac gccgtcggca cggcgtggac 93540
cgtcctgcag gccgtccccg tctcggtgtt caccatcctg caactcgccg cactgcgccg 93600
cagaacctga ccaccgctac gcggcccgcg ccgagcgcgc caggtagcgc catcccttct 93660
tgtcttggag ttccccatga ccacggacag ccagccggta aacgcgccgc gcaggacgac 93720
ccgcagacgc ggatcacgtc aagccggggt ctgtacgacg tcgccgtcga gttctcccgc 93780
tggcgatctc ccggtttggg ctgtgcgtcc ccttcaagtt cgagaacctg tggttgaact 93840
agtgcggatt ccccaggtag ggaaagtccg tgcgaaggtc ggtgtggggc cggagcccgt 93900
cgtggggcac ggcaccgttg ctcagctggg cgatccccat gttgatgaca tcgtcggtga 93960
ggttgcggcc gttggggaat ccttcggcgc tggcgtagtc atacgtcagg agatcgggga 94020
gcaagctttc cgcgagagcg ttggcccggt cctcggggtg gcccgcgtgc tcgaagacgt 94080
gcgcgaactt ggcgaggaag ccttcgcgat cgtgggacgg ttcctgctgg ttccagacgc 94140
gtttgtcatc gtcgtcctgg ttgaagttgg cgtcgatccc gggccgtccg gcccgatcgc 94200
cctggaccag tcggccgtcg tgcggaacca gcaccctggc ccagacaccc acccgtgggt 94260
tcgggccgag cgccctgttc gggacttcca gcacgatgcc gaacacgttc ttgtcggcga 94320
agaagtcctc gccggtccac tggaacttgt tctccgcacc gacggggtcg gcgaagaacg 94380
ggtcgctgcg cagcccggcg aagaacctga attcaccggc cgcggcgatc cgcggctcgg 94440
agccgaaggt caccggtgcg tcgagaagga ccgtgtctcc cgcgtcgagg tcggctgcgg 94500
cctcccggcc ggtcgccagt tgcaggcttg cggtctgctc gtgcccctgt acgggtgaga 94560
agcggatgcg gaacgcgatg tcggtgaccg cgtcggcgtc ggtgtccacg ccgagctcgt 94620
agaccgactc gtggtcgacg gcgtcgtcgg tgatcggcga ggtcggattg acgttgatca 94680
ccaggatcgt tctgctcgca tcgtccggct tctgaaatac gtagaggtcg gtgatgtggc 94740
tcctgggatc caggctggtg gggctgatgc ccagaccgga gacgtggtgt gccatttcgc 94800
gactcccatc aggtggctgt gcagaccgaa gtgtgctgcg gcgcggtgga gccttgatgc 94860
ttcgtcgcgg gaagcgcagc gcctcggcgt tgccctccca cccgggacga tcacccgatc 94920
acccattggc gacctacgcg aaggtcgccg catcgctcat gacttgagga acttagagag 94980
caacaatctg cctgtcgcca gcggctgtac atccgtcatc cgacgtattc gcggcggtcg 95040
caactgcccc tcccctggcc tggcttggcc tggcttggct tggcttggct gtcgacagca 95100
cagggtccaa ctcctacggg aaccgagcgc gggcccgccg gccgacttcg aataccgcgc 95160
tcgttgtaca accgatcggc taacccttgg ggcgtacacg tttgtcaacc cggtgcggga 95220
cgacgctggg caacccccgg tcatagcttc acgacacaca ccgcgtcctc gcggctgtgc 95280
cgatgaccgg aaaggtgaag tgatctcatg acccgtgctt cgttcacccg caccagactg 95340
cgccgtacgg cggtggcggc aggcgccttc atcgcgctga cgacagccgt cggagccacc 95400
caggcatccg cccactccgc cgcccagaag cagagcggat cccgggtgac cgccgcaccg 95460
tccgactgcc ccaagtacta cttctgcggc tacaaggacg ccaacttcaa gcgcctggcg 95520
ttcaagttca aggactgcta catgcaggag atcccggacg gcctgaacag cggcggctcc 95580
tggtacaaca accagtccgc gggcaccaag gccaagatgt tcaacgagcg caagcagctg 95640
atcttcacca cccccggagc cccctccagt gacccctccg gcaactggca tcccgtctgg 95700
tacgtcgacg cctgctgacc ctcaccacca gtgaggtgcc gggctgccca ggacatcctc 95760
ttgggcagcc ctccggcacc cgtcccgctt ctcggcccgc ggcgacgaaa tccagttgaa 95820
ctccttgatc cagccttcct tgaggcgcca gaagtcggcc ttcggaatgg cgagctcggc 95880
accggtcggc cgttcgacgc cgacgggcgt ttcgaacggt ccggtgaagc ccgcatcgcc 95940
agctcgacgt ggtgatctcc cgcagcggtg ttcatcccac tcgcgacctc ggcgggcaat 96000
gaacaggtgc acagcgcacg ccacttggcg gacaacgagg ctgtcgtcgc gctgatcgac 96060
gacgtctcgt cggagcaacg gcaaatcgcc gacgccccac tgctcaccga ccggcaccag 96120
cgcgaggcga cggcggagcg cgcccggacc cacagtgcct cagcgcagcc ccgccgttga 96180
caggaatgac ctgccctgtg atgaacgccg cgtcctgccc tgccaagaag gtcacggccc 96240
ccgcgatgtc ggccccttgg cccaggcacc gcagcgagag cctgcctggc gcgctcgtcg 96300
tgcagggcgc ggagcatgtc ggtgtccacg gttccgggtg ctatggcgtt gacgtccgca 96360
cggatctcgg cgcccgcgac ggacgcgctg aggtcgtgcg cccgtacggt gaccgcctcg 96420
gtgatctcgg tcagttcggg ggtcatacgg cccccatccc gagtacggag acgaggcggc 96480
cggggtcacg agggcggtgc ggcccactcc tgccgcggcc cggtgtaccg gggagaggtc 96540
ggagcggaac gctgccgcgg ccatgacccg ttcgaagagg tgccatccgg cgaaggcgac 96600
cgcgcgcacc gccagtccgt cgtcgggggc cgaccgcacg gaccggtatc cctcggcgaa 96660
ggcgacgagc gtgggcagga cctcgtccag tcgccgtctc gccgaccacc gcgccgacgt 96720
cccgggccgc gtcgccctgc cggaactcct cccagtcgga gagaagcaac ttccagatac 96780
tgactcatcg acaaggcggc gaggatgcgg tggttcggca ttggcaatgg ctcgcgaggc 96840
agcatttctg acgacactcg caatttctga ggacactcgc agcgaatgca gttcaccgag 96900
cgcccgccca aggcttcggg cgagttccgg cccgaatatg ccatcggcga ccgcgtcagc 96960
tgccgtacgg caatctttca gccaacgcgt gacgtgaatt ccgcgggtcg cgtcgctcgc 97020
cagcggagtc ggccatcgca ggtgccgcaa gggcagctcc ccgcccagtc gttcgaaccg 97080
ctcggctcgc cgcagaccgg ccctggcctg accggtggca cgaatgcgcc tggcgaaaac 97140
gtcgatcccc gtggtcgtcg tgcccgccac gttctggttc cgtccggaga aggtcaccac 97200
ggtgtccgac aggaactccc cgtatcccgc cgcacgaatg aagtctgcta tctccgcatc 97260
cggcatgcct cgactctgcg ggtcggcaag gtccttgatc aagcatttcg aagatgttcg 97320
aaaatgtttc gccaggggtt accagccgag gcgtaccatg cgatgaacca tgcgcaacgg 97380
gggcgtgtgg cgcgaaacgg gggcaagaaa tgaacagtta ttcaaggctg cagctcggcg 97440
ggctttccga gctgcgcatc caggtcgtac cgcatcccgg ggcgagcctg ctctcgctcg 97500
tcgcggacgc gttcggacaa cggcggcacg ccgtaccggg cccggcacgc aaggcagttc 97560
gcaccggtgc tccggcgcat gccgagataa cgcttcgtcc gctcttcaca cccgagcatc 97620
cggccattcc cgactgtctg acgccgacgg ggaccatgtc ccacgaaggc gcggcccatc 97680
atctggaaca gttgcgggac ctgccgcccg acacgctcct ggcggacctc gaggcggact 97740
tcggcggcga agtccccacg cagtggcgtc atgtgatcgc gcacccgaag cgatggctcc 97800
aggggtacgc ccaagtcatg cagcgcacat gggagaccat gcagccggta tgggcagcgg 97860
ccggcgacgc gctgcgccga gaggcggagc gggtgggcgc ctccatggtg ttcggccacc 97920
ccgaactggc gctgtccgcc ctcagcgtgc gctaccgcct cgacggcacc gtgctgcagc 97980
tgccggacac gcaccccgag gacttcgacc tcctcggtcg tcgactggcc ctcgtgccgg 98040
tcgcctccgg tagtgaggcg tccctgttcg ccttcgacgc gccggacatc gcgtgggtgg 98100
gctacccgct ccccaacctc gacgcactct ggtccggtcg gctcccgcag gcccgggcga 98160
cgcgcccgga cccggcacga ctcattctgg gcgacgcgag ggccgccatc cttcgcgcga 98220
ccagtgcggc cacccacatg ggcaacctgt cgtcgaccct gggctacgcg cccggaacga 98280
tgtcccatca ctgcgcgcgg ctggaggacg cggggctcat ccgtcggtgc cggcgggggc 98340
agcatgtgat ggttcatcgt acgcagttgg gcagcgagct cttcgacttg ctcactcact 98400
gactgagcct ggccgcccgg ccggcttgga ccgcgaggcc cacaagcggc gcgacaccgt 98460
cgaacggcgc atgaacaggt cagtcacccg atcacaggac gagcatgagc ttgccgccgg 98520
gccgacggga ctggctgagc tgggccgcct cctggatctg gtcgagcgtg taggtgcggg 98580
cgaccgatac gacgagaacg ccttcggcgg ccagccgggc gaactcgccc atccggtcgt 98640
aacgcatctc gatctgggtg attcgggtgc ccagctcggc cgcggcggcg aagtccgaga 98700
cggtgaggac gcggtcgggg tccccggtca gcccgatcaa ggacggcagc gagccgccgc 98760
ccgggctggc ctggtgggca cggtcgatcc ggccgccggt cggggccgtg tccagggcgc 98820
ggtcgacgcg gcctccggcc agtgcggcga cgcgttcggc cataccgtcg ccgtagccgg 98880
tcacccgggc gccgatctct cccagggccg cggcccgcgt cggcccggcg gcggcaatca 98940
cccggacacc ccggtgcaac gccaagcgca ccgccgcctc acccacggtg gagcccgcgc 99000
cgtggacgag cagcagctca cccggctgga cgccgaggtc gtcgagcgcg tgccatgccg 99060
tctcggccgc catcggcagc gcggcggcct gctctgcggt gacaccctcg ggaatgtgcg 99120
cccagaccgc catcagcgcg tactcggaag ctccggccgt cggaccgtcg aaggtcgccg 99180
ggccgaacac gcggtcgccg atctcgacgc cgatgatgcc ctcaccgagc gcgtcgacga 99240
cacccgcgac ctcgacgccg agcccgcgcg gcagtggcgg caactggtcg gcgagcaggc 99300
cgtcgaccac cgcccagtcg cccggcgtca ggccgcacgc ccgcacggcg atccggatct 99360
ggccgggtcc cggctccggc ttcgggacct cgcggagcac gatcacgtcg ggggatccga 99420
accggtcgaa ctgaagagcc ttcatgacga tctcctaagt gatgacagca tctgttgtca 99480
tcgatcctag cgtcacgacg acagcctctg ctgtcatatg ctggtgggca tgccgagatg 99540
ggagtcagac gcacagggcc ggctcaagcg cgcggcgctc gagctgttcg agacgcaagg 99600
gttcgagcgc acctcggtcg cacagatcgc gcgcaccgca ggcctgaccg agcgctcctt 99660
ctaccgctat ttccccgaca agcgggaagt cctcttcgcc gacgacgggc tccaggccca 99720
cctcgtcgcc caagtcgaag cggcggaccc gggcctcacg ccgatcgagg cgctgctggc 99780
cgcgctgggg acagccgacg agatcttccg cccgcgcgag ttcctgctgc gccgcgtcag 99840
ggtgatcgcc gccagcccgg cactggccga gcgcgacctg atcaagctcg ccgacatcgc 99900
cgacgcgctg gcccgggcgc tcgaacaccg tggcgtcgag cccggcaaag cacgcttcat 99960
catcgacgtg gcgattgcga tctcccggcg cgccacgtcc cgctggctgg ccgacccgga 100020
ggcgaccctc tccgatctcg tcgcccagac cgccgccgaa ctgcgtgagg tggtcgcgcc 100080
accgaccccg acggtcggct gaggctgccg cagcgcagcg actgcgatac gtcctgcgcc 100140
atgcacccga accgaaacga tgcaagagcc aacgcaggag gtcaccggct ctaagcggct 100200
ccgccgaaat ccgctgctga tccgcaccta cggtactggg ggtgagcttg tggcaagatc 100260
gcgggatgct gcgactcacc gatttcatta tcgactgccc ggacacgatg aagctggcgg 100320
ccttctactc cgaggtgacg ggccgtccga tcaagaaggg cagctctgag gactgggctg 100380
gcatccagtt cggcgagatc gagctggcat tcatccgggt ggacgactac cgcgctccgc 100440
agtggcccga cagccagcac cccaagcagt tccacctcga cttcgaagtg gacgagatcg 100500
agcccgagca gcgccgtgtc ctcgacctcg gcgcgacgct gaggcaggac ttcatcggcc 100560
ccaacggcta cggctggcag gtctacaccg acccgatcgg ccaccccttc tgcctgtgcc 100620
gcaacaaggg tgtcacctgg accgaccagg gtccgatctg gcccaagcac gactgagcgg 100680
cttcgcccac cggcggcacc gagtacgccg acggtgagca cgcaggctgc gagcgtcttc 100740
cttgaggtca gcaggcagat cggctggggc accgaccatg ccccagccat ttcagtggcc 100800
tcccggttgt ctcgcagccc ccgcttgcgc tggtaggcgc cagcgcggtc aactccagat 100860
cagctcacgc tcacactcaa ccgcccaagg caaggaacgc cgagtcggat gggttgagag 100920
accaacctcc cccgccagag cggcagttca gcgccgtgtc ggctgtgccc gacgcgttgg 100980
tgccggtgtt gaagttggca ttgggagtgt tgggcaggac gcccatgtag tactgcccgc 101040
tcgacgtcca cacacactgg tgcaggttga ggtaccggtt gccggccagg tcgaacgact 101100
tgacggcgga gttggccagg agcagccgcc agccgccccc tccagggcca cagttcagct 101160
tcgtgtcggc cgtgttggag acgttggtgc cggtgttgaa gttgacgttc ggagtgttcg 101220
ggagcacagc cgtgtagtgc tgcccggcag agaagtacac gcactggtgc acgttcaggt 101280
accgaccggc ggtgaggtcg aaggccttca ccgcggagtt ggcgggcgcc ggcctccagc 101340
ctccaccccc cggtccacag gagagcgcgg tgtcgggcgt gttggagacg ttcgtgccgg 101400
tgttgaaggc ggtgttcgcc gtgttcggca gcacgttcgt gtagtgcccg ccgctcccga 101460
cgtagacgca ctggtggagg ttcagatagc gctcagccgg ccgcactcct ggctggtccg 101520
ccacggcggt gcttcccagg gtcaggccga tggctcccgc aactgctgcc gcgacaacgg 101580
aaaacctgcg catggcacgc tcctcctgaa ccgatgacgc cgccccatca cggcatgtac 101640
tcaccaagct actgacgcga gcccagaaga gtgcacgagc acacatgagg taacccgtat 101700
ggcctagtcc cccggtacgg aagccgcctg gtaatccttg agccggaagg cgttgagctt 101760
cgcgaagacc gccgcggacg cgtcgtcctc gtgcggggcg agcggcgcga cctggtccgc 101820
cgccgcttcc tgcttcgcgc gcatggcggc ccggttgatc agtgcgaatt cctggttgag 101880
ggccacgaag tcgcgcaact ccctttcgta cgcggcgaag gccgtgcggt gatcgccgag 101940
cgcggcgtcg agctcgcccg ccaggatgta cgcggcggtc atggccatcg tcgtgccctg 102000
gcctgaggcg ggcgacgcgc agtagcccgc gtcgccgagg agggtgatcc ggccgtggga 102060
ccagctgtcc aggtggatct gcgccagcgc gtcgaggtgg aagtcgggtg cgtcccacat 102120
ctccttgagc agcctcggca cctcccagcc cgcgccttcg tacgcgcccg ccaccaggtg 102180
cttctgctcg acggtgtccc gcgggaggaa acgtgcgggc ggccggtcgg attcgatgcc 102240
gatgaaggcg cgggcctccg agttgccccg gacgctcatc accatcgcac cccagacgtc 102300
acgccccggc atctggtaga tcacctccca gcggtccagg ccgaggtggt tgggtaccgt 102360
ccatacgccg aggtaagcac ccaggtggcg caggtagtcc tcctcggggc cgaagacgag 102420
cccgcgggtg tgggagtgca cgccgtcggc gccgacgacc agatcgaagg tgcgtgacgt 102480
gccgctgtcg aacacgaccc gcacctcatc gtcgtcctgt tcgatcgtgg cgatggagtc 102540
cccgaagagg tactcgatgt cgctgccgcc cgcgtcgtac aggatccggg cgaggtcgtc 102600
gcgcaggatc tccacgtccg ggctggcgat ctgcccgccg ctcacggtgt gttcggtgct 102660
cctgaacagc tcttcgccgt cgtcgtcgac gaccgacatc ccgcgcaggt cggtactccg 102720
acggcgcatc tcatccagta cgcccatgcg ttcggccact tcgagagccg ggcctcggac 102780
gtcgatcgcc tgcccgcccg gccgcaggcc cacccaccgc tccaccaccg tgacccggaa 102840
cccgtactgg ttcagccagt aggcgagggt ggggccaccg atgctggcgc ctgagatcag 102900
gacactgacg ttcttcgggc tcttcgattc cctgcgcatg gacactgcgg gctcctcgac 102960
agtctgcgga acttccgtac gtacgagact gctcgaccgc gccgacaggg caccgacaag 103020
tcgcctacaa ccaccggcgc gcacctggtg gggctgctac gaggctggtt cctcgtggcc 103080
gtcaccgtcc catgaaacgt ctgagacatc cgcgttccac tcgaccggtg cgaccggtgc 103140
gaccggtgcg cctgacgtgc ccgcgcggca ccggctgcgc aggaacaagg tgcccgaggt 103200
caccgtctac ttctggatca tcaaggtgct gtgcacgacg gtcggtgaga ccgcggccga 103260
cctgctgaac gagaaggcgg gcctcggact caccggtgtg tccgtgctga tgagcgcgct 103320
gctggccggg gtgctcgtgg tgcagttccg cacgtgcgcc taccgggcgg gcgtgtactg 103380
gctcgccgtg gccctgatca gcatcgtcgg cacgctgatc agcgacaacc tcaccgacaa 103440
catgggggtg ccgctggaca cgagcacggc ggtgttcgcg atcgccctcg cggtggtgtt 103500
cgtcgtctgg taccggcggg agcggacgct gtccatccac agcatcgaca ccaccggccg 103560
ggagtccttc tactggctcg cggtgcgctt cacgttcgcc ctgggcaccg cggccggtga 103620
cctggtctcc gagcgcatgg acctcggcta ctggctcggc gcttcggtcg gcgactacct 103680
ctcccagtcg gccggggacg gcggcctcgg cctgggcacg gtggtgacca gcacgctctt 103740
cctggccgtc atcctcggcc tggtcgtgta tctggcggtg acgcgcaagg acgtcaccga 103800
ggctgagcgg gaggccggac tcccggcctg acctctggct tctgacccct ggctcctggc 103860
tcctgccctc tggcggtgtt gcgcggccgc gccccggtca cccgccgggc aggctgaccg 103920
tgaatctggc tccgggggtg tgcccgggat cgtggggcac ctcgccgccg acggcgcggc 103980
ggcctggttg gaagagttca cccacgaacg tttccggcac cccggggccg tcatcgacga 104040
catcgatacg tacggttccg gggacttgcc gcgcggacac agacacggtc acgtgggagt 104100
gggcgtaccg ggcggcgttg gcgagcaggg ggctcaggat gcgttcgagg agggcagggg 104160
caactcccgc caccagggcg ggggttggtg gctccagcag cacgagtttc acccggcccg 104220
gtggggtgaa gttccggagc aggcggtcga tgatcggccc cacgtcggtg gcgccgggga 104280
ccgtcgccgg atcgagggcg ctctcgcgcg cgtcgtccag gacggtatcg cggatggtgc 104340
gcatggaccg ggcggcctcg gcgaccgcct ccagggtggc ccgggtctcg gcatccgtac 104400
gggggcggga tccccaccag ccgagctcca tgacgatccg ggtgagcggc gtacgcagtt 104460
cgtgggacag ctcgcccgtc agctgccgtt cgtggcgcag cacggtgcga atgcggtcca 104520
ggagcgcgtc caacgaggca ccgaggcggg cgagttcggc cgggtgaccc gccgtgccga 104580
accgttcgtc ggaggccacc gcgctccact gcgtggcctg gtccgtcatc gcccgcaccg 104640
ggcgcagcgc ccgcccgacg gacagccggg tcagtgcgta cgtgcagccg agcatcacca 104700
cgtccaggac gagcgatccg agcagcaggg tgtccgccga actgcggtac ggcgtcaggt 104760
ccagagcggt gaccacggcg gcaacggtgg cgtcggcccg gcggtcgggg agcgggtatg 104820
cgcacagccg aatggtgtgg acgatctcgc aggcgcgccc gtcccgcgtc gccagccggt 104880
cggcggcccg ggtgagcggg ctgtcggccg cggcggacgg cggcctctcc agcaggcggc 104940
ttccggtgta gatccacaca ttcgcgtcga gcaggcggtc gttggcggtc tccaggacgc 105000
gtacgcgagg tccgccggtg tcgacggtcg tggccaccgc cgccgcccgg gtgcgcagtt 105060
cgtgatctgc ctggcgctac aggtgctcgt ccatcacggc gttgaacacc acggtcagca 105120
ccgtcatcag cagggcggcg gtggccagcg cgacgaggga gaggcggccg cgcagagtgc 105180
gtggggccag acggcgcatg ccgttcccgg tgcggcgcgc gacgtaccca gtgcggcgca 105240
cgacgttccc ggtacggttc acgacaggcg gtgtccgatc ccgcgcgccg tgtcgatcga 105300
caagccgctg cccgcctcgc gcagcttgcg gcgcaaccgg ctcaggtact ggtccagcgt 105360
gttgtcgctg acgtgcgcgc cttcgggcca accggccctg accaggtcac ggcggcgcac 105420
gagatcgccg tccgcggcga cgagcggggc aagcagccgg aactccgtgg gggacagtgc 105480
gatgcggacg ccgtgcacgg tcgcgtggtg gccgaccgcg tcgaggacca ggtcaccggt 105540
cgcggccggg gagcggggac tggcgcgctt gagtgcggcg cgcaaccggg cggcgagttc 105600
agcgaggtgg aagggcttgg gcaggtagtc gtccccgcct gcggagaacc ggccagccgg 105660
tcggtgagct ggtgacgggc ggtcaggaag atgacagggg cgaggaaacc gttggcgcgc 105720
agtgcctggc acacgtcccg gccgtccgcg tcgggcaacc cgacgtccag gaccagcgcg 105780
gcgacgtcgg cggtgaccaa ccgcagggcc gtggcaccgt cgacggcggg cacggggtcg 105840
aagccctcgt cccgcaggcc gcggcgcagg acgtcacgca ggacgtcacg cagggcgtga 105900
tcgtcctcca ccaccaggat cttggggcgc atggttctcc tggttctccg tcggctgcgg 105960
ggcgtgagcc gtcgtgtgag tgaggaacgg agcgggcaac aggtaggcgg ccgcgcacag 106020
acacgccccc agccagccga gggcgaacag ccagccgccc aggacatcgg tgaaccagtg 106080
cacgccgagg taggcccggg tcactccgac gaacaagccc cagcagccca cggcgatccg 106140
gagcgcggtg ccgccgtgcg tgcggcgcag ggtgagcgcg gcgatcagca gaccggccgt 106200
cagagcggcc gtggtggtgt gcccggacgg gaaggcccag ccgctcgcgt gcgccgtcca 106260
gtcgctctgg ggcgggcgta cgcggtggat gaactccatc agggcgtacc gcagtacctg 106320
gccgaggccg aggcaggcaa ggcagaggac ggcggcgagc agccggtgcc acagggtgcg 106380
ccccgccacg actccggcca ggacgacgag tacgtacggg accacgccgg tgccggaggc 106440
ggtcacgccc cgcgccacgg ccacggccac ctccgggcgg tggccgaccg accaggcgag 106500
gaaaccgtcg tccagccaga ggggtgaacc ggcccggccg accacgacca gggccaggac 106560
cccgaacgcc gcccatgcgc ccagcgcgac gctgacgagc agatcggcgg cgtccccgcg 106620
gttcacgagt cgggttcggt tctcggggcc tccgcggttc ttggggcctg cgcggctttt 106680
ggggcctccg cggttcttga gaccgacgcg gcccttcagg cccacgcggc tcatgagact 106740
gacgcggctc atgagaccga tgccgttcgt gaagccgtga gcagcaggcg cagcggagtc 106800
accgccgtca tccgccgggc cagtgccggt gaccggcgcc ccaccacgag catcgcggcg 106860
agggcgacga gcgcgcccac cagcagcccc gccaggacgt cgtgcggata gtgcactccc 106920
acccagaccc gcgaggccgc catggcggcc gccgccccac aggccaccgc tcccaggcgt 106980
cgcgagacga acagcagcgc cacggccgcc gccgcggcga tcgccgcgtg gttgctgggg 107040
aaggaccagt caccgggcgc cggacacgcc tccagggtcc ggccgcccaa gctctggcac 107100
ggtcggtcct ccctgacgat cagcttcagg acgtcgtcca ggacgaacgc cagggccgcc 107160
gccacgggaa cggccagtgc cgtcacggcg gccgcggctc ccgcgcgccg ggcccgccac 107220
catcccagga ccatgaggag cgcgaacacc gcgaggccgt acgccgacca cgccgtcacc 107280
gcggcgtcca gccagcccgg cgcccgctgc gcgaggtccg ccacttcccg gtagccggag 107340
ccgtcgatcg acgccccgtc gaacgcgagg atcatccccg gacctcttca gccttgccgc 107400
gcccacgccc tcggtacgac tcggcaacga acgcgttgag cgggcccacc gcgagctgcg 107460
acgataggac gggcaggacc acgggtgtac tcatcggcat gcgtcccttc cctacggacc 107520
accgaatgcg tggcatccgg catgcacaac acctgaccga ctacaagcat gtagacggtc 107580
tacgttactg tagacgacgc gggggtgagg atcgttccca tgaacagcga gaaggacgac 107640
cggcggtcgg cgggcgagct ggaggccgcg gtgatggccg cgctgtgggc cgcggacgca 107700
ccgctgactc ccgcccgcgt ccaggccgaa ctcgcctcgg acctggcccg caccaccgtg 107760
acgacgatcc tgtcccgcct gtacgagaag gggacactcg aacggcagcg gcagggccgt 107820
ggctacgcct accaccccgt acaggacccg cagggcctga ccgccctgcg catgcacggc 107880
gaactcgacc gcgacagcga ccgcgagacg gtcctcgccc gcttcgtcgc ccaactcgac 107940
ccggacgacg agcaggtcct gcgccgcctc ctcgaagagg gcccatgacg atcgcggtgc 108000
tgctgatccc cctgctgctg ccctgcgcgg cgccgctgct ggcgcgccgg agcctgggcc 108060
accgctcccc cgtggtcgcc ctgtggacgc tcaccgcctc ggcgctcctc ctcgcggcgg 108120
gcaccgtcgc ggcgctcggc acgctggccc tgaccgggct gttcaagatc ccggccttcg 108180
cctccgtggg cgagctggtg cacccgctgc ggacaccgtc cgtgcggctg gtccttccgc 108240
tggccgcgct cgccgccgga ctgctcgcgc tcggcgcgct cgccctcggc cgctcggtcg 108300
tacggcaggc cacggccctg cgtaccgccc ggtccgaggc cggtcgcagg cccccggcgg 108360
gcgacctgtg cgtcgtcgag tccccgcgcc ccgacgcgta cgccctgcca ggccgcccgc 108420
accgcatcgt cgtcacgacc gccatgctgc gcagcctcga cgcccgcgag cgcgaggcgc 108480
tcttcgccca cgagcgcgcc cacaacgcgg gcggccacca ctacttcctg tccgcggccg 108540
agctcgccgc gcactgccac cccgctctgc gcccggtccg cgcggccatc cggctcgccg 108600
ccgagcgggc cgccgacgag gccgccgcga ccgccgtcgg cgaccgccgc ctgaccgcgc 108660
gcgccatcgc ccgcgccgcc ctggccgcac acgcgacgga caccgcgcgg cccgtggtga 108720
cgcccgcggc caccaccagt cccgtgccgc agcgagtggc cgccctgctc tcccccgccg 108780
cccggccccg gcgggccacg tcctgggtcg ccgccctgct ggccgtctgc gcgttcgcgt 108840
cctgcgccac cgcggcgacc gtcgccgtcc gcgtccacca ggacatcgag gtcgcccagg 108900
gcgagaccgg ccgctgagca gccgtcaccg ggacgctggt tcgcaccgtc agtcgagcgc 108960
cgtgtcgccc tgggcggtca cgagggtttc gccgcgtctg gtgaggcgga tctgcaccga 109020
gcggcggtca ctgctctcgc ggacacgttc gaccaggccc ttgcccttca ggcggtcgat 109080
gcggttggtg acggcgccgg ggctccccag ggcggccttg gcgaaggccc cggcggtgag 109140
cgtgtagggc ggtcctgagc ggcgcagcgt gaagatcatg tcgagttcgc cgaggttcag 109200
gccgaacgtg tcggacagct tcttgaagtg ccggtcgtag acgcgccgca cccgctggat 109260
ccgcccgaag atctccatcg cgcccagggc gtcggccagt tcggggcact ccgcgcgccg 109320
ctgctcgccg atcaggtcca ccgcatcggt cattcccggt ctcctcccgt gccatatatt 109380
tcaaccttaa gagactcgcc attgagcgat acggcatgtt tctatttcga tgtcaaaaga 109440
tctgacgttg aagcagttga ccggcctccg agaccctcgc gaagggcacc tcgccccgcg 109500
gcgacgccta ccgctacctc gccacgcagg agtccaccgg cggcgactac ggcctctacc 109560
aggtggacct ggcggcacgg gccgcgggcg ccaggaccca cttccacaag gcgatgtcgg 109620
aagccttcta cgtcctctcc ggtgaactgg agctcttcaa cggcgacacg tgggtgaccg 109680
gccggaccgg cgacttcctg tacgtaccgc ccggcggcct gcacgccttc aagaacgtga 109740
ccgacgagcc cacgtcgatg ctcatgctct tcgcgacggg aaccgcgtaa ctgaccgcca 109800
gcggatgacc gttgcccgat ccggatgagg cagagcgccg aagcgtccta cggtttcgaa 109860
gaaatcggtg ctctggaggc atatatggac agctgtcgcg gtgcgcggac ggccgtgatc 109920
gtgggtgcgg gggtggctgg tctgacagcg gccaccgccc tggcacgcga cgggtggcag 109980
gtggagatcg ccgagatcgg cccgccggag gcgcctgccg gatgggggtt gtgcctgacc 110040
gggccttcgc tgcgtgcgct ggacgagctg ggtcttgcgg acgcgtgtct ggccgagggc 110100
tacggcatga gcaccctcac gtacatggac gtgaacggcg agcccagggg cgagctccag 110160
ctgccgcgcc tgatgggcac gcgacgaccg gcgatggccg gtatcgcgcg ccccgtgctg 110220
caccgcatcc tgcacgcgga agccgagagg cacggcgtag tggtacgcca tggagtgacc 110280
gtcgtcgcgg tggatcagga gggggacctc gtccgcgtgc ggttgtcgga cgggacggtc 110340
cgcaaggtcg cgctgctggt cggcgcggac ggggtccgct cgtcggtgcg gggcctgttg 110400
gggcttgaga cctcgatcga cttccacggg cagatggtct ggcgcgctct ggtcccccgc 110460
ccgcggtggg ccaccggaat ccatcagttc gccgggaagg ccgacacggc aggactcgtc 110520
cccctctcgg gcggtcaggc atacgtattc cttacggaga acggagtgga gcagagcgtc 110580
ctgcccgatg cccgactcgc cccgcgcctg aggcaactcc ttgaggcttt ccccggccgg 110640
gtggaggaga tccgctccct ggtgtccatg tcgacatcgg tggtgcgccg cccggtcctc 110700
accgcgttcc tggcaggcgc ctggaaccgc ggcagctgcg tggtcatcgg ggacgccgcg 110760
cacgcgcccg cacctcagat ggccagtggc gccgccctgg ccatcgagga cggtctcgta 110820
ctggcccggg aactcgggcg gcacgagacc gtcggcgcgg ggctccgggc gttcgtcagg 110880
cgacgcgcgc agcgctgccg gacgctcgtg gagacctcgg tgacgatcgc ccgcctggtg 110940
caggcgcggc gccatcacga ggcgtatccg ctggtcgatt cctgccaccg gctcatggcc 111000
gagcccgcgt aaccttccgg cgcgaacggc gtgccgccga ccgccgtgga cgacagtgga 111060
cgacaaggga cgacaaggga caatggcctc ctaggaggtg agcccgccgt cgtgccaacg 111120
ccgctgcgca accacccctc accagctcgc agaaccccgc cgatctgctg aacgccgcca 111180
cccgtctgtt cggcggctcg atcgtcacat cgccgctggg cgagctgtgc ggcggcgatc 111240
acgaactgcg cggcgtcgcc gcacacgact tcgccgtggg ctacttcgcc tcgccgctcg 111300
atgtgcgcgt cgcctcggcc aagagccgtc gccgcggctc ctacttcgtc aacatcggtg 111360
tctccggcgc catctcggcg tcgcgcggca acctgcgggc gaccctcgac gaggcgacgg 111420
caggagtcgt caaccccgga gacatccagg aactacggcc cctgcgcggc ccgcagacgc 111480
ggttcctcgg cctgcggatc gacgccgccc tggtcgacca ggagttcgcg acgctgaccg 111540
ggcatccgcc ggtgtccacc gtgcgcttcg acttcgccct cgacctggcc gggtccaagg 111600
gccgggcggt gcggctgctc gtccgctccc tcctcgaaca gctggactcc ggagaccccc 111660
tgttccagcg cgcggagctg cagcgcagcc agctgcgctg cctcgtcacc gccctgctcc 111720
tggcccagcc gcactcgcac accggcgagc tgcacgacgg tccgcgcccc ggccatccgc 111780
gctccttgcg ggcggccctc gcgttcatcg aggcgaacct cgccgagcac atcagcgtcg 111840
acggcatcgc cgccgcggca ggttgcagcc cgcggaccct cagctccgcg ttccgcggcc 111900
gactcggcct ctcccccatg gcgtacgtcc gcaacctgcg cctcgacgt 111949
<210> 55
<211> 426
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 55
Met Thr Ser Gly Val Ala Phe Leu Phe Pro Gly Gln Gly Ser Tyr Val
1 5 10 15
Pro Gly Val Phe Ala Gly Ile Gly Ala Asp Ala Asp Arg Ile Ser Ala
20 25 30
Arg Val Ala Glu Ile Asp Ala Val Thr Ala Glu Phe Gln Leu Glu Pro
35 40 45
Val Gln Pro Leu Leu Phe Ser Pro Asp Ala Pro Ala Leu Ala Gln Leu
50 55 60
Leu Glu Ser Asp His Glu Arg Leu Asp Val Ala Ile Leu Ala Thr Ser
65 70 75 80
Ile Ala Leu Ala Glu Leu Leu Glu Ser Arg Tyr Glu Met Arg Pro Asp
85 90 95
His Val Val Gly His Ser Leu Gly Glu Phe Gly Ala Leu Ala Val Ala
100 105 110
Gly Val Phe Thr Pro Gly Glu Ala Ala Arg Ala Val Cys Glu Arg His
115 120 125
Ala Thr Leu Arg Lys Ala Pro Pro Pro Glu Gly Gly Met Leu Ala Val
130 135 140
Asn Ala Asp Thr Ala Arg Ala Glu Glu Leu Ile Ala Ser Ala Lys Ala
145 150 155 160
Glu Ala Ser Ala Val Ser Ala Arg Asn Ala Pro Ser Gln Thr Val Ile
165 170 175
Ser Gly Thr Glu Ala Asp Leu Val Lys Val Arg Gln Leu Ala Arg Glu
180 185 190
Ala Glu Ile Arg Thr Ser Arg Leu His Val Pro Gly Pro Phe His Val
195 200 205
Pro Gln Leu Ala Asp Ala Ser Ala Leu Tyr Ala Arg Thr Met Arg Asn
210 215 220
Val Arg Met Ser Ala Pro Arg Glu Arg Phe Phe Tyr Ser His Gly Leu
225 230 235 240
Gly Arg Phe Leu Thr Ala Arg Asp Asp Val Val Asp Leu Met Val Ala
245 250 255
Asp Met Thr Arg Pro Val Arg Phe His Asp Ala Val Arg Ala Leu Asn
260 265 270
Ala Glu Gly Val Thr Thr Phe Val Glu Cys Gly Ala Leu Asp Val Leu
275 280 285
Thr Arg Ile Val Ser Gly Ser Leu Pro Arg Ala Val Thr Leu Ala Pro
290 295 300
Leu Arg Glu Ala Met Asp Thr Ser Asp Leu Ser Ala Arg Leu Arg Thr
305 310 315 320
Ala Gln Pro Ser Ala Ala Ala Gly Glu Pro Thr Pro Thr Ala Ala Ala
325 330 335
Asp Ala Glu Val Leu Glu Gly Val Arg Ala Val Cys Ala Glu Ile Leu
340 345 350
Glu Tyr Pro Leu Asp Val Val Thr Ala Asp Ala Asp Phe Gln Ala Asp
355 360 365
Leu Gly Val Asp Ser Leu Ala Met Thr Glu Leu Gln Glu Arg Ala Leu
370 375 380
Arg Arg Phe Asp Leu Gln Asp Arg Val His Asp Ala Thr Ala Gly Thr
385 390 395 400
Tyr Ala Thr Val Ala Gly Leu Ala Leu Tyr Ile Thr Gly Leu Leu Arg
405 410 415
Glu Gly Ala Thr Thr Gly Ala Glu Gln Arg
420 425
<210> 56
<211> 1281
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 56
atgaccagtg gggtggcgtt cctcttcccc ggccaagggt cgtacgtgcc gggtgtcttc 60
gccggtatcg gcgcggacgc cgaccggata tcggcccgtg tcgcggagat cgacgcggtg 120
accgccgagt tccaactcga gccggtgcag cctctgttgt tctcgcctga cgccccggcc 180
ctggcacagc tgctcgagtc cgatcacgag cggctcgacg tggccatcct tgcgacgtcc 240
atcgccctgg cggagctcct ggagtcccgg tacgagatgc gtcccgatca tgtcgtcggg 300
cacagtctcg gggagttcgg cgcgctggcc gtcgccgggg tgttcacccc cggcgaggcc 360
gccagggcgg tctgtgaacg gcacgccacc ctgcgcaagg cgccgccgcc cgagggcggg 420
atgctggcgg tgaacgcgga cacggcccgt gccgaggagc tgatcgcttc ggcgaaggcc 480
gaggcgtcgg ccgtgtcggc gcggaacgcg ccgagccaga cggtgatcag cggcaccgag 540
gcggacttgg tcaaggtacg gcagctggca cgagaggcgg agatccgcac gtcccggctg 600
catgtccccg gccccttcca cgtgccgcag ttggccgacg cgagtgccct ctatgcgagg 660
acgatgcgga acgtgcggat gtccgcgccc cgcgagcgct tcttctactc ccatggcctg 720
ggccgcttcc tgaccgcgcg ggacgacgtc gtcgatctga tggtggccga catgacccgt 780
ccggtgcgct tccacgacgc cgtgcgcgcg ctgaacgccg agggggtcac gaccttcgtg 840
gagtgcggcg cgctggacgt cctcacccgg atcgtgtccg ggtcactgcc ccgtgcggtg 900
accctggcac cgctccgcga ggccatggac acgtccgatc tgtccgcccg gctgcggacc 960
gcccagccgt cggccgcggc cggggagccg acgccgaccg ccgcggccga tgcggaggtc 1020
ctcgaaggag tacgcgcggt gtgcgccgag atcctcgagt atccgttgga cgtggtcacc 1080
gccgacgccg acttccaggc cgatctcgga gtcgattccc tggcgatgac cgaactgcag 1140
gaacgcgcgt tgcgacgctt cgacttgcag gacagggtcc acgacgccac cgcgggaacg 1200
tatgccacgg tcgccggtct ggccctgtac atcaccggcc tgctgcgcga gggcgccacc 1260
acgggcgccg aacagcggtg a 1281
<210> 57
<211> 798
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 57
Val Thr Ser Gly Ser Pro Asp Asp Ala Gly Thr His Ala Asp Thr Val
1 5 10 15
Ala Val Val Gly Met Gly Ile Ala Val Pro Gly Ala Cys Asp Thr Asp
20 25 30
Glu Leu Trp Lys Leu Leu Ser Gly Asp Arg Pro Val Phe Glu Glu Pro
35 40 45
Gly Asp Arg Phe Pro Leu Asp Ser Phe Trp Ser Pro Asp Pro Ala Ala
50 55 60
Glu Asp Arg Ala Tyr Val Arg Thr Ser Gly Phe Leu His Asp Phe Arg
65 70 75 80
Pro His Pro Arg Leu Ala Glu Glu Ile Ala Ala Gly Thr Phe Ser Ala
85 90 95
Ala Asp Gln Asn Pro Val Trp Leu Arg His Cys Leu Leu Arg Ala Arg
100 105 110
Asp Thr Val Thr Ala Arg Asp Thr Asp Arg Tyr Ala Tyr Tyr Val Gly
115 120 125
Ser Ser Thr Leu Val Gly Gln Arg Thr Asp Glu Ala Thr Leu Ala Glu
130 135 140
Ser Val Ala Leu His Thr Ala Glu Arg Leu His Gly Asp Asp Pro Val
145 150 155 160
Arg Arg Ala Glu Ala Ala Glu Arg Leu Arg Ala Leu Leu Gly Arg His
165 170 175
His Gly His Gly Ala Gly Arg Pro Val Asp Thr Leu Pro Asp Arg Val
180 185 190
Ala Arg Ala Ala Ala Ala Gly Leu Leu Pro Ala Asp Cys Glu Phe Ala
195 200 205
Val Val Asp Ala Ala Cys Ser Ser Ser Leu Tyr Ala Ile Gly Leu Gly
210 215 220
Val Ala Ser Leu Leu Ala Gly Asp Cys Asp Val Ala Tyr Cys Gly Gly
225 230 235 240
Val Ser Gly Val Thr Pro Arg Tyr Asn Val Thr Phe Ser Lys Leu Arg
245 250 255
Gly Leu Ser Thr Gly Gly Asp Val Arg Ala Phe Asp Arg Gly Ala Asp
260 265 270
Gly Thr Leu Phe Ser Asp Gly Ala Gly Ile Val Ala Leu Lys Arg Leu
275 280 285
Gly Arg Ala Val Glu Asp Gly Asp Ala Val Leu Gly Val Leu Val Gly
290 295 300
Phe Gly Gly Ser Ser Asp Gly Arg Gly Thr Ala Ile Tyr Ala Pro Asn
305 310 315 320
Pro Lys Gly Gln Arg Arg Cys Leu Asp Arg Ala Trp Arg His Ala Gly
325 330 335
Leu Thr Ala Asp Asp Ile Asp Trp Val Ile Ala His Gly Thr Gly Thr
340 345 350
Ala Val Gly Asp Ala Val Glu Leu Lys Thr Leu Ala Glu Ala Thr Asp
355 360 365
Pro Gly Gly Leu Trp Cys Gly Ser Asn Lys Ser Leu Leu Gly His Thr
370 375 380
Gly Trp Ser Ser Gly Val Val Ser Val Val Gln Ala Leu Thr Ala Leu
385 390 395 400
Arg Glu Gly Ala Ile Pro Ala Gln Arg Arg Phe Ile Glu Pro Gly Leu
405 410 415
Thr Ala Glu Asn Gly Asp Gly Val Arg Val Pro Val Asp Ala Val Pro
420 425 430
Trp His Glu Gly Gly Pro Arg Pro Arg Val Ala Gly Val Ser Ala Phe
435 440 445
Gly Phe Gly Gly Thr Asn Ala His Leu Leu Val Ala Asp Arg Ala Pro
450 455 460
Val Pro Arg Val Arg His Val Pro Pro Pro Glu Thr Asp Pro Val Val
465 470 475 480
Leu Leu Ala Trp Thr Ala His Leu Pro Gly Asp Pro Asp Pro Ala Ala
485 490 495
Val Ala Arg Leu Val Arg Asp Gly Arg Ala Pro Gly Pro Arg Thr Phe
500 505 510
Gly Pro Arg Tyr Pro Ala Pro Pro Phe Pro Asp Val Arg Leu Pro Pro
515 520 525
Pro Thr Val Arg Ser Thr Asp Ala Gly Gln Leu Met Ala Leu Arg Val
530 535 540
Ala Ser Leu Phe Ser Ala Glu His Gly Glu Leu Trp Asp Pro Val Arg
545 550 555 560
Ala Thr Thr Gly Val Phe Ala Ala Ala Gly Gly Pro Pro Pro Ser Ala
565 570 575
Met Asp His Leu Val Arg Cys His Ala Ala Glu Leu Asp Gly Leu Leu
580 585 590
Asp Gly Pro Asp His Ala Ala Phe Thr Asp Trp Leu Asp Glu Leu Arg
595 600 605
Ser Thr Thr Pro Pro Thr Thr Lys Asp Thr Leu Pro Gly Ile Leu Pro
610 615 620
Asn Ile Ile Pro Ala Arg Ile Ala Asn Arg His Asp Leu Gly Gly Pro
625 630 635 640
Thr Met Leu Val Asp Thr Gly Ala Thr Ser Gly Leu Thr Ala Val His
645 650 655
Thr Ala Ala Arg Gln Leu Ala Arg Gly Asp Val Asp Met Ala Leu Val
660 665 670
Leu Gly Val Ser Ala Thr Ala Arg Pro Glu Phe Ala His Val Met Gly
675 680 685
Ile Asp Pro Glu His Ile Ala Glu Gly Ala Phe Leu Leu Ala Leu Ser
690 695 700
Arg Asp Ser Val Ala Arg Ala His Gly Leu Asn Pro Leu Ala His Val
705 710 715 720
Arg Thr Ala Trp Ser Gly Thr Pro Gln Pro Ser Thr Arg Phe Thr Cys
725 730 735
Gly Ala Ala Gly Thr Gly Arg Thr Phe Leu Gly Ala Asp Gly Val Leu
740 745 750
Ala Val Ile Arg Ala Leu His Ala Asp Ala Ser Asp Val Ala Val Gly
755 760 765
Pro Ala Asp Gly Ala Pro Gly Pro Val Ile Thr Leu Ser Pro Val Ala
770 775 780
His Ser Ala Thr Cys Cys His Arg Gln Thr Arg Thr Ser Arg
785 790 795
<210> 58
<211> 2391
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 58
gtgacctccg gcagcccgga cgacgcgggc acacacgcgg acaccgtcgc cgtggtgggg 60
atgggcatcg cggtcccggg agcctgcgac acggacgagc tgtggaagct gctgagcggg 120
gaccggcccg tgttcgagga gcctggggac cgcttcccgc tggactcctt ctggtccccc 180
gaccccgccg ccgaggaccg cgcctacgta cgcacctcgg gcttcctgca cgacttccgg 240
ccccaccccc gcctcgccga ggagatcgcg gcgggcacct tctcggccgc cgaccagaac 300
ccggtctggc tgcggcactg cctcctgcgg gcacgggaca ccgtcaccgc ccgcgacacc 360
gaccggtacg cctactacgt cggcagcagc accctcgtcg ggcagcgcac cgacgaggcg 420
accctggccg agtccgtcgc cctgcacacc gccgagcgcc tgcacgggga cgatcccgtc 480
cggcgcgccg aggcggcgga acggctgcgc gccctgctgg ggcgccacca cgggcacggc 540
gccgggcggc cggtggacac gctgcccgac cgtgtcgcgc gggccgcggc cgccggactg 600
ctgcccgccg actgcgagtt cgccgtggtg gacgccgcct gctcatcctc gctctacgcg 660
atcggcctcg gcgtcgcgag tctgctggcc ggtgactgcg acgtcgccta ctgcggcggg 720
gtgtcgggcg tgacgccgcg ctacaacgtc accttctcca aactgcgcgg gctgagcacc 780
ggcggggacg tgcgtgcctt cgaccgcggg gcggacggaa ccctgttctc cgacggcgcg 840
ggcatcgtcg cgctcaagcg cctggggcgg gccgtcgagg acggtgacgc cgtgctcggc 900
gtcctcgtgg ggttcggcgg atcctcggac ggcaggggca cggcgatcta cgcccccaac 960
ccgaaggggc agcgccggtg cctcgaccgc gcctggcggc acgccggact gaccgccgac 1020
gacatcgact gggtgatcgc gcacggcacg ggcaccgcgg tcggcgacgc cgtggaactc 1080
aagaccctgg ccgaggccac cgaccccggc ggcctctggt gcggatccaa caagtcgctg 1140
ctcggccaca ccggttggag ctccggcgtg gtctcggtcg tccaggccct cacggcactg 1200
cgggagggcg cgataccggc gcagcgccgc ttcatcgagc ccggtctcac ggcagagaac 1260
ggcgacgggg tacgcgttcc cgtcgacgcg gtcccgtggc acgagggcgg cccgcgcccc 1320
cgcgtcgcgg gcgtctccgc cttcgggttc ggcggcacca acgcccatct gctggtagcc 1380
gaccgggccc ccgtcccacg cgtccggcac gtcccgcccc cggagaccga cccggtggtc 1440
ctcctcgcct ggaccgccca cctgcccggc gacccggacc ccgcggcggt ggcacggctg 1500
gtgcgcgacg gccgtgcccc gggaccgcgg acgttcgggc cccgctatcc ggcaccgccg 1560
ttcccggacg tccggctgcc gccacccacg gtgcggtcca ccgacgcggg ccagctcatg 1620
gccctgcgcg tggcgtccct gttcagcgcc gagcacggcg agttgtggga ccccgtgcgc 1680
gccaccaccg gagtcttcgc cgccgcgggc ggtccgccgc cgtccgcgat ggaccacctg 1740
gtgcgctgcc acgccgccga gctggacggc ctcctcgacg gtcccgacca cgcggcgttc 1800
accgactggc tcgacgagct caggtccacg accccgccga ccaccaagga cacgttgccg 1860
ggcatcctgc ccaacatcat cccggcgcgc atcgccaacc gccacgacct cggcggcccc 1920
accatgctgg tggacacggg cgccaccagc ggactcaccg ccgtgcacac cgcggcccgg 1980
caactggccc gcggcgacgt ggacatggca ctcgtcctcg gtgtcagcgc cacggcacgg 2040
ccggagttcg cgcacgtcat gggcatcgac cccgagcaca tcgcggaggg cgccttcctc 2100
ctcgccctga gccgtgactc ggtcgcccgc gcccacggcc tgaacccgct cgcccacgtc 2160
cgtacggcgt ggagcggcac tcctcagccc tcgacgcgct tcacctgcgg agcggccggg 2220
acagggcgga cctttctcgg cgcggacggc gtcctcgccg tgatccgcgc cctgcacgcc 2280
gacgcgagcg acgtcgccgt gggccctgcg gacggtgcgc caggaccggt catcaccctc 2340
tcccccgtcg cccacagctc gccccaccgg cagacaagga ccagccgatg a 2391
<210> 59
<211> 445
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 59
Met Ser His Leu Arg Asp Ala Ala Ala Thr Asp Asp Pro Gly Ala Ile
1 5 10 15
Ala Ala Cys Asp Val Pro Ala Glu Tyr Arg Ala Ala Val Val Leu Ala
20 25 30
Ala Asp Gln Gln Ala Leu Ala Gly Thr Pro Val Glu Ser Arg Asp Pro
35 40 45
Arg Lys Thr Val His Val Gln Glu Val Ala Thr Pro Glu Leu Asp His
50 55 60
Gly Glu Val Leu Ile Ala Thr Met Ala Ser Ser Ile Asn Tyr Asn Thr
65 70 75 80
Val Trp Ser Ala Leu Phe Glu Pro Val Ser Thr Phe Arg Phe Leu Arg
85 90 95
Thr Leu Gly Arg Thr Ser Pro Glu Ala Ala Arg His Asp Leu Pro Tyr
100 105 110
His Val Leu Gly Ser Asp Leu Ser Gly Val Val Leu Arg Thr Gly Pro
115 120 125
Gly Val Arg Glu Trp Lys Pro Gly Asp Glu Val Val Ala His Cys Leu
130 135 140
Gln Pro Asp Leu Gln Thr Pro Gly Gly His Asp Asp Thr Leu Leu Asp
145 150 155 160
Pro Gly Gln Arg Val Trp Gly Tyr Glu Thr Asn Phe Gly Gly Leu Ala
165 170 175
Glu Leu Ser Leu Val Lys Ala Asn Gln Leu Met Pro Lys Pro Ala His
180 185 190
Leu Thr Trp Glu Glu Ala Ala Ser Leu Gly Val Ala Leu Ser Thr Ala
195 200 205
Tyr Arg Gln Leu Val Ser His His Gly Ala Asp Met Lys Gln Gly Glu
210 215 220
Arg Val Leu Ile Trp Gly Ala Ala Gly Gly Val Gly Ala Tyr Ala Thr
225 230 235 240
Gln Leu Ala Leu Asn Gly Gly Ala Ile Pro Val Cys Val Val Ser Ser
245 250 255
Gln Ala Lys Ala Asp Leu Cys Arg Arg Met Gly Ala Glu Leu Val Ile
260 265 270
Asp Arg Ala Ala Glu Asp Phe Thr Phe Trp Asp Glu Gln Asp Lys Pro
275 280 285
Arg Leu Ser Glu Trp Ser Arg Phe Arg Ser Ala Val Arg Asn Leu Ala
290 295 300
Gly Asp Asp Pro Ser Ile Val Ile Glu His Pro Gly Arg Asp Thr Phe
305 310 315 320
Gly Val Ser Val Met Ile Thr Ala Arg Gly Gly Ser Val Val Thr Cys
325 330 335
Ala Ser Thr Thr Gly Tyr Gln His Ser Tyr Asp Asn Arg His Leu Trp
340 345 350
Met His Val Lys Arg Ile Ile Gly Ser His Met Ala Asn Tyr Arg Glu
355 360 365
Ala Trp Ala Ala Asn Asp Leu Val Val Arg Gly Ser Ile His Pro Val
370 375 380
Leu Ser Arg Ala Tyr Pro Leu Asp Ala Val Gly Asp Ala Thr His Ala
385 390 395 400
Val Ala Gly Asn Ser His His Gly Lys Val Gly Val Leu Cys Leu Ala
405 410 415
Asp Arg Pro Gly Met Gly Val Arg Asp Pro Asp Leu Arg Ala Arg Lys
420 425 430
Leu Asp Arg Ile Asp Leu Phe Gln Lys Gly Gln Gln Arg
435 440 445
<210> 60
<211> 1338
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 60
atgagtcacc tccgcgacgc cgcggccacc gacgacccgg gggccatcgc cgcctgcgac 60
gtccccgccg aataccgcgc cgccgtcgtc ctcgcggcgg accagcaggc tctcgcggga 120
acgcccgtcg agagccggga cccccgcaag acggtccacg ttcaggaggt cgccacccct 180
gagctggacc acggcgaggt cctcatcgcc accatggcca gctccatcaa ctacaacacc 240
gtgtggtccg cgctgttcga accggtctcc accttccggt tcctgcgcac gctcggccgg 300
acctccccgg aagcggcccg gcacgacctg ccctaccacg tgctcggctc cgacctttcc 360
ggagtcgtgc tgcgcaccgg acccggcgta cgcgaatgga agccgggcga cgaggtcgtc 420
gcgcactgtc tgcagccgga cctgcagacg ccgggcgggc acgacgacac gctgctcgac 480
cccggacagc gggtctgggg gtacgaaacg aacttcggcg gcctcgccga gctctccctg 540
gtcaaggcga accagctgat gccgaagccc gcccatctca cctgggagga ggccgcctcc 600
ctgggggtcg cgctctccac cgcgtaccgt cagctggtct cccaccacgg ggcggacatg 660
aagcagggcg aacgcgtcct gatctggggt gccgcgggcg gtgtcggcgc gtacgcgacc 720
caactggccc tcaacggcgg cgcgatcccc gtctgcgtgg tgtcctcgca ggccaaggcc 780
gacctgtgcc gccggatggg cgcggagctc gtcatcgacc gcgccgcgga ggacttcacc 840
ttctgggacg agcaggacaa gccgcgcctc agcgagtgga gccgcttccg cagcgccgtc 900
cgcaatctcg cgggggacga cccgagcatc gtcatcgaac acccgggccg ggacaccttc 960
ggcgtcagcg tcatgatcac cgcccgtggc gggagcgtgg tcacctgcgc ctcgaccacc 1020
ggctaccagc acagctacga caaccggcac ctgtggatgc acgtcaagcg catcatcggg 1080
tcacacatgg cgaactaccg cgaggcctgg gccgccaacg acctcgtcgt acggggcagc 1140
atccacccgg tgctctcgcg ggcctatccc ctcgacgccg tcggcgacgc cacccacgcc 1200
gtggcgggca acagccacca cggcaaggtc ggcgtgctgt gcctcgccga ccgtcccggc 1260
atgggagtgc gtgaccccga cctcagggcc cgcaagctcg accggatcga ccttttccag 1320
aaaggacaac agcggtga 1338
<210> 61
<211> 386
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 61
Val Ser Glu Pro Glu His Leu Asp Thr Val Arg Lys Phe Val Ala Gln
1 5 10 15
Glu Val Leu Gly Arg Glu Thr His Leu Asp Ser Leu Ala Asp Ala Pro
20 25 30
Leu Ala Leu Tyr Glu Arg Phe Ala Glu Thr Gly Leu Met Asn Trp Trp
35 40 45
Val Pro Glu Glu His Gly Gly Leu Gly Leu Gly Leu Glu Asp Ser Val
50 55 60
Arg Ile Val Ser Glu Leu Ala Tyr Gly Asp Ala Gly Val Ala Phe Thr
65 70 75 80
Leu Phe Leu Pro Ile Leu Thr Thr Ser Met Val Ser Trp Tyr Gly Ser
85 90 95
Ala Glu Leu Lys Glu Lys Leu Leu Asp Pro Leu Val Ala His Arg Gly
100 105 110
Phe Cys Ala Thr Leu Gly Ser Glu His Glu Ala Gly Ser Glu Leu Ala
115 120 125
Lys Ile Ser Thr Val Val Arg Arg Asp Gly Glu Gly Leu Val Leu Asp
130 135 140
Gly Thr Lys Ala Phe Ser Thr Ser Thr Asp Phe Ala Gln Phe Leu Val
145 150 155 160
Val Ile Ala Arg Ser Ala Glu Asn Pro Thr Arg Tyr Leu Ala Val Ala
165 170 175
Val Glu Arg Asp Ala Pro Gly Leu Arg Ile Asp Lys Arg Trp Asp Val
180 185 190
Ile Gly Leu Arg Ala Ser Ala Thr Tyr Gln Val Ser Phe Ser Asp Cys
195 200 205
His Val Pro Ala Gly Asn Ala Leu Asp Gly His Gly Leu Arg Leu Leu
210 215 220
Glu Ile Gly Leu Asn Ala Ser Arg Ile Leu Ile Ala Ala Thr Ala Leu
225 230 235 240
Gly Val Ala Arg Arg Ile Arg Asp Leu Cys Met Glu Tyr Ala Lys Thr
245 250 255
Lys Ser Leu Lys Gly Ala Pro Leu Val Asn Asp Ala Val Phe Ala Gly
260 265 270
Arg Leu Gly Gln Phe Glu Met Gln Ile Glu Val Met Ala Asn Gln Cys
275 280 285
Leu Ala Ala Ala Arg Thr Tyr Asp Ala Thr Ala Ala Arg Pro Asp Ala
290 295 300
Ala Arg Thr Leu Leu Arg Gln Gly Ala Gln Lys Ser Ala Leu Thr Ala
305 310 315 320
Lys Met Phe Cys Gly Gln Thr Ala Trp Gln Ile Ala Ser Thr Ala Ser
325 330 335
Glu Met Phe Gly Gly Ile Gly Tyr Thr His Asp Val Pro Ile Gly Lys
340 345 350
Leu Leu Arg Asp Val Arg His Ala Ser Ile Ile Glu Gly Gly Asp Asp
355 360 365
Val Leu Arg Asp Leu Val Phe His Arg Phe Val Val Pro Thr Ala Lys
370 375 380
Arg Thr
385
<210> 62
<211> 1161
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 62
gtgagtgagc ccgaacacct cgacaccgtg cggaagttcg tcgcccagga agtcctgggc 60
agggaaaccc acctggactc gctggcggac gcgccgctgg cgttgtacga gcggttcgcg 120
gagacgggcc tgatgaactg gtgggttccc gaggagcacg gcggcctcgg gctcggtctc 180
gaagacagcg tgcggatcgt ctccgaactc gcctacgggg acgccggagt ggcgttcacc 240
ctgttcctgc ccatcctgac caccagcatg gtcagttggt acggcagtgc ggagctgaag 300
gagaagctcc tcgaccccct cgtggctcat cggggcttct gcgccacgct gggcagcgag 360
cacgaggcgg gcagcgagct ggccaagatc tccaccgtgg tgcgccgcga cggcgaagga 420
ctcgtgctcg acggcaccaa ggccttctcc accagcaccg acttcgcgca gttcctcgtc 480
gtcatcgcgc gctcggcgga gaacccgacc cggtatctgg cggtcgccgt ggagcgggac 540
gcgccgggac tgcggatcga caagcgctgg gacgtcatcg gactgcgcgc ctcggcgacg 600
taccaagtgt cgttctccga ctgccacgtg cccgccggga acgcgctgga cggccacggt 660
cttcgcctcc ttgagatcgg gctcaacgcc agccggatcc tgatcgccgc caccgcgctc 720
ggcgtcgcgc gcaggatccg cgacctgtgc atggagtacg cgaagacgaa gtcgctcaag 780
ggcgctccgc tcgtcaacga cgcggtgttc gccgggcggc tcggccagtt cgagatgcag 840
atcgaggtga tggcgaacca gtgtctggcg gcggcgcgca cctacgacgc gacggcggcc 900
aggccggacg ccgccaggac gctgctgcgg cagggcgccc agaagtcggc gctgaccgcg 960
aagatgttct gcgggcagac cgcctggcag atcgcctcca ccgcgtcgga gatgttcggc 1020
ggcatcggat acacgcacga cgtgccgatc ggcaagctgc tgcgggacgt ccggcacgcc 1080
tcgatcatcg aaggcggcga cgacgtcctg cgcgatctgg tcttccaccg cttcgtcgtg 1140
cccaccgcga aacgcacgta g 1161
<210> 63
<211> 222
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 63
Met Ala Asn Gln Val Thr Met Ser Asp Ala Leu Leu Ala Tyr Val Arg
1 5 10 15
Lys Val Ser Leu Arg Asp Asp Glu Val Leu Ser Arg Leu Arg Ala Glu
20 25 30
Thr Ala Gly Leu Pro Gly Gly Ser Val Leu Pro Val Gln Ala Glu Glu
35 40 45
Gly Gln Leu Leu Glu Phe Leu Val Leu Leu Thr Gly Thr Arg Gln Val
50 55 60
Leu Glu Ile Gly Thr Tyr Thr Gly Tyr Ser Thr Leu Cys Leu Ala Arg
65 70 75 80
Gly Leu Pro Pro Gly Gly Arg Val Val Thr Cys Asp Val Thr Ala Lys
85 90 95
Trp Pro Glu Val Gly Arg Pro His Trp Glu Arg Ala Gly Val Ala Asp
100 105 110
Arg Ile Asp Val Arg Val Gly Asp Ala Arg Asp Val Leu Ala Gly Leu
115 120 125
Leu Asp Glu Ala Gly Ala Gly Pro Gly Ser Phe Asp Val Val Phe Ile
130 135 140
Asp Ala Asp Lys Ala Gly Tyr Pro Ala Tyr Tyr Glu Ala Val Leu Pro
145 150 155 160
Leu Val Arg Gly Gly Gly Leu Ile Val Val Asp Asn Thr Leu Phe Leu
165 170 175
Gly Arg Val Ala Asp Asp Thr Ala Arg Asp Pro Asp Thr Leu Ala Val
180 185 190
Arg Ala Leu Asn Ala Ala Leu Arg Asp Asp Asp Arg Val Asp Leu Ala
195 200 205
Met Leu Thr Thr Ala Asp Gly Ile Thr Leu Leu Arg Lys Arg
210 215 220
<210> 64
<211> 669
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 64
atggcgaatc aggtgacgat gtccgacgcg ctgctcgctt acgtccgcaa ggtctcgctg 60
cgcgacgacg aggtgctgag ccgcttgcgc gcggagacgg ccgggctgcc gggtggcagc 120
gtcctgccgg tacaggccga ggagggtcaa ctcctcgagt tcctggtgct gttgaccggc 180
acgcggcagg tgctcgagat cgggacgtac accggttaca gcacgctctg cctggcccgt 240
ggattgccgc cggggggccg ggtggtgacg tgcgacgtga cagcgaagtg gccggaggtg 300
ggcaggccgc actgggagcg tgccggggtg gccgaccgga tcgacgtacg ggtcggcgac 360
gcccgggacg tgctcgcggg gctgctcgac gaggcgggcg cggggccggg atcgttcgac 420
gtcgtcttca tcgacgcgga caaggcgggc tatccggcgt actacgaggc ggtgttgccg 480
ctggtgcgcg gtggcggcct gatcgtcgtc gacaacacgc tgttcctcgg gcgggtggcc 540
gacgacacgg cgcgggaccc ggacacgctc gcggtccgcg cgctcaacgc ggcgctgcgc 600
gacgacgatc gggtggatct ggcgatgctc acgacggccg acggcatcac cttgctgcgg 660
aagcggtga 669
<210> 65
<211> 362
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 65
Met Thr Thr Thr Thr Ile Val Lys Cys Leu Val Trp Asp Leu Asp Asn
1 5 10 15
Thr Leu Trp Arg Gly Thr Val Leu Glu Gly Asp Glu Val Val Leu Thr
20 25 30
Asp Glu Ile Arg Glu Val Ile Ser Thr Leu Asp Gly Arg Gly Ile Leu
35 40 45
Gln Ala Val Ala Ser Lys Asn Asp His Asp Val Ala Trp Gln His Leu
50 55 60
Glu Arg Leu Gly Val Ala Glu Tyr Phe Val Leu Pro Arg Ile Gly Trp
65 70 75 80
Gly Pro Lys Ser Gln Ser Val Arg Glu Ile Ala Glu Gly Leu Asn Phe
85 90 95
Ala Pro Ala Thr Leu Ala Phe Val Asp Asp Gln Pro Ala Glu Arg Ala
100 105 110
Glu Val Ala Phe His Leu Pro Glu Val Arg Cys Tyr Pro Ala Glu Gln
115 120 125
Val Thr Ala Leu Pro Ala Leu Pro Glu Phe Arg Pro Ala Ala Ser Thr
130 135 140
Val Asp Ser Arg Arg Arg Arg Leu Met Tyr Gln Ala Gly Phe Ala Arg
145 150 155 160
Asp Gln Ala Arg Glu Thr Tyr Ser Gly Pro Asp Glu Asp Phe Leu Arg
165 170 175
Ser Leu Asp Leu Tyr Met Thr Ile Ala Pro Ala Gly His Glu Glu Leu
180 185 190
Thr Arg Val Glu Glu Leu Thr Leu Arg Thr Ser Gln Met Asn Ala Thr
195 200 205
Gly Val His Tyr Ser Asp Ala Glu Leu Arg Ala Leu Leu Ala Asp Pro
210 215 220
Ala His Glu Val Leu Val Val Thr Met Gly Asp Arg Phe Gly Pro His
225 230 235 240
Gly Ala Val Gly Ile Val Leu Leu Glu Lys Thr Pro Arg Val Trp His
245 250 255
Leu Lys Leu Leu Ala Thr Ser Cys Arg Val Val Ser Phe Gly Ala Gly
260 265 270
Ala Thr Ile Leu Asp Trp Leu Thr Asp Arg Ala Ala Arg Ala Gly Thr
275 280 285
His Leu Val Ala Asp Phe Arg Arg Thr Glu Arg Asn Arg Leu Met Glu
290 295 300
Val Ala Tyr Arg Phe Ala Gly Phe Ala Glu Thr Ser Cys Ala Cys Val
305 310 315 320
Ser Ala Leu Gly Glu Ala Ala Gly Arg Val Glu Arg Leu His Leu Glu
325 330 335
Pro Ser Pro Arg Pro Thr Pro Lys Thr Leu Thr Leu Thr Ala Ala Asp
340 345 350
Gly Ile Pro Phe Thr Ala Ser Ala Ala Arg
355 360
<210> 66
<211> 1089
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 66
atgaccacca cgaccatcgt caagtgcctg gtctgggact tggacaacac cttgtggcgg 60
ggcaccgtgc ttgagggcga cgaggtggtg ctcacggacg agatccgcga ggtgatcagc 120
acgctcgacg gccggggcat cctccaggcg gtggcaagca agaacgacca cgacgtcgcc 180
tggcagcacc tggaacggct cggcgtggcc gagtacttcg tgctgccgcg catcgggtgg 240
gggccgaagt cgcagtccgt ccgcgagatc gccgaaggcc tgaacttcgc ccccgccacc 300
ctcgcgttcg tcgacgacca gcccgccgag cgtgccgagg tcgcgttcca cctgcccgag 360
gtgcggtgct acccggccga gcaggtgacc gcgctcccgg cactgccgga gttccgcccg 420
gccgcttcca cggtcgattc gcgccgacgt cgcctgatgt accaggccgg attcgcgcgc 480
gaccaggcca gggagacgta ctccggtccc gacgaggact tcctgcgctc cctggacctg 540
tacatgacga tcgcgcccgc gggccacgaa gagctcaccc gcgtcgagga gttgaccctg 600
cggaccagtc agatgaacgc gaccggcgtg cactactccg acgccgaact gcgcgcgctg 660
ctcgccgacc cggcgcacga ggtcctcgtc gtcaccatgg gcgaccgctt cggcccgcac 720
ggcgccgtcg gcatcgtcct gctggagaag acgccgcggg tgtggcacct gaagctgctc 780
gcgacgtcct gccgggtcgt gtcgttcggt gccggtgcga cgatcctcga ctggctcacg 840
gaccgggccg cccgggccgg gacgcatctg gtggcggact tccggcgtac ggaacgcaac 900
cgcctgatgg aggtcgccta ccggttcgcc ggtttcgcgg agacgagctg tgcctgcgtg 960
tccgcgctgg gcgaggcggc cggccgcgtc gagcgcctgc atctggagcc ctcgccgcgc 1020
cccacgccga agacgctgac gctgaccgcc gccgacggca ttccgttcac cgcttccgca 1080
gcaaggtga 1089
<210> 67
<211> 366
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 67
Val Pro Glu Arg Asp Ala Leu Leu Thr Gly Leu Val Gly Asp Arg Ala
1 5 10 15
Ala Gly Trp Asp Thr Ser Gly Glu Leu Pro Arg Asp Leu Leu Val Arg
20 25 30
Leu Gly Ala Asp Gly Leu Leu Cys Ala Glu Ala Ala Val Glu His Gly
35 40 45
Gly Leu Gly Leu Gly Ser Arg Glu Asn Gly Gln Phe Thr Ala His Val
50 55 60
Gly Ser Leu Cys Ser Ser Leu Arg Ser Val Met Thr Ser Gln Gly Met
65 70 75 80
Ala Ala Trp Thr Val Arg Arg Leu Gly Asp Thr Gly Gln Arg Ser Thr
85 90 95
Tyr Leu Lys Glu Leu Thr Ser Gly Lys Leu Ala Ala Val Gly Phe Ser
100 105 110
Glu Arg Gln Ala Gly Ser Asp Leu Ser Ala Met Arg Thr Arg Val Arg
115 120 125
Ile Glu Gly Asp Thr Ala Val Val Asp Gly His Lys Val Trp Thr Thr
130 135 140
Ala Ala Ala Tyr Ala Asp His Leu Val Val Phe Gly Leu Gln Glu Asp
145 150 155 160
Gly Ser Gly Ala Ala Val Val Val Pro Ala Asp Thr Ala Gly Val Arg
165 170 175
Val Glu Arg Val Pro Asn Pro Ser Gly Cys Arg Ala Ala Gly His Ala
180 185 190
Asp Leu His Leu Asp Gly Val Arg Val Pro Val Gly Ala Val Leu Ala
195 200 205
Gly Ser Gly Ala Ser Leu Pro Met Leu Val Ala Ala Ala Leu Ala Tyr
210 215 220
Gly Arg Lys Ser Val Ala Trp Gly Cys Val Gly Ile Leu Arg Ala Cys
225 230 235 240
Arg Val Ala Ala Thr Ala His Ala Arg Thr Arg Glu Gln Phe Gly Arg
245 250 255
Pro Leu Ala Asp His Gln Leu Val Ala Gly His Leu Ala Asp Leu Trp
260 265 270
Thr Ala Glu Gln Val Ala Thr Arg Val Cys Glu Tyr Ala Ser Asp Arg
275 280 285
Trp Asp Glu Gly Ser Pro Asp Ala Val Thr Ala Thr Val Leu Ala Lys
290 295 300
His Val Ala Ala Glu Arg Ala Ala Ala Gly Ala Ala Thr Ala Ala Gln
305 310 315 320
Val Leu Ala Ser Ala Gly Ala Thr Glu Gly His Val Val Glu Arg Ala
325 330 335
Tyr Arg Asp Ala Lys Leu Met Glu Ile Ile Glu Gly Ser Ser Glu Met
340 345 350
Cys Arg Met Met Leu Ala Arg His Ala Leu Ala Leu Pro Ala
355 360 365
<210> 68
<211> 1101
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 68
gtgcctgagc gcgacgcgct gctgaccggc ctcgtcggtg accgggccgc aggctgggac 60
acgtcgggcg agctgccccg cgacctgctc gtccgcctcg gcgccgacgg cctgctctgc 120
gcggaggccg ccgtcgagca cggcggtctg ggcctcggca gccgcgagaa cggccagttc 180
accgcgcacg tcggcagcct ctgcagttcg ctgcgcagcg tcatgacgtc gcaggggatg 240
gccgcgtgga ccgtgcggcg gctcggcgac accggccagc ggtcgacgta cctgaaggag 300
ctgaccagcg ggaagctcgc ggcggtcggc ttcagcgagc gccaggcggg cagcgatctg 360
tcggcgatgc gcacgcgggt gcggatcgag ggggacaccg cggtcgtcga cggccacaag 420
gtgtggacca ccgcggccgc gtacgcggac cacctggtcg tcttcggcct ccaggaggac 480
ggttccggcg cggcggtggt cgtgccggcc gacaccgcgg gcgtacgcgt cgagcgtgtc 540
ccgaatccgt cgggatgccg tgccgcgggc cacgccgacc tgcacctcga cggtgtgcgg 600
gtgccggtgg gcgcggtcct ggccgggtcc ggggcgtcgc tgccgatgct cgtcgcggcg 660
gcgctcgcgt acgggcgcaa gtcggtcgcc tggggctgcg tcgggattct gcgggcctgc 720
cgagtcgccg cgacggccca tgctcggacc cgggagcaat tcggccgacc gctcgccgac 780
catcaactcg tcgccgggca cctcgccgac ctgtggaccg ccgaacaggt cgcgacgcgc 840
gtgtgcgagt acgcgagcga ccgctgggac gagggctcgc ccgacgcggt gaccgcgacg 900
gtcctggcca agcacgtcgc ggcggaacgt gccgccgcgg gcgccgccac cgccgcgcag 960
gtgctcgcgt cggcgggcgc gaccgagggc cacgtcgtcg agcgggcgta ccgcgacgcg 1020
aagctcatgg aaatcatcga gggcagcagc gagatgtgcc ggatgatgct ggcgcgccac 1080
gcgctggcgc tcccggcgtg a 1101
<210> 69
<211> 283
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 69
Met Ala His Arg Ile Leu Val Leu Gly Ala Gly Val Met Gly Thr Gly
1 5 10 15
Ile Thr Thr Leu Ala Leu Arg His Gly Val His Val Thr Leu Val Asp
20 25 30
Thr Ser Asp Ala Ile Leu Val Ala Ala Arg Thr Arg Ile Ala Ala Glu
35 40 45
Leu Arg Met Ala Gln Leu Val Ala Gly Pro Ala Glu Ala Asp Pro Gly
50 55 60
Val Leu Glu Thr Thr Thr Ser Val Leu Pro Ala Ile Gly Met Ala Asp
65 70 75 80
Ala Val Ile Glu Ala Val Val Glu Asp Ala Val Val Lys Ala Asp Val
85 90 95
Leu Ala Thr Val Ser Ala Ala Ala Pro Pro Gly Thr Pro Ile Ile Thr
100 105 110
Asn Thr Ser Ser Ile Pro Val Asp Glu Leu Ala Asp Ala Val Ala Arg
115 120 125
Pro Glu Asn Leu Leu Gly Thr His Phe Met Asn Pro Ser Tyr Val Ile
130 135 140
Pro Thr Val Glu Val Ile Arg Gly Pro Arg Ser Gly Glu Pro Ala Met
145 150 155 160
Ala Ala Val Ala Asp Leu Leu Ala Val Leu Gly Arg Lys Pro Ile Val
165 170 175
Val Arg Asp Ala Pro Gly Phe Val Thr Ser Arg Leu Leu His Pro Met
180 185 190
Ile Asn Asp Ala Ala Arg Ile Val Gln Glu Gly Thr Ala Ser Thr Glu
195 200 205
Asp Val Asp Ala Leu Met Thr Gly Cys Leu Gly His Pro Thr Gly Pro
210 215 220
Leu Arg Thr Ala Asp Leu Ile Gly Ile Asp Asn Leu Val Asp Ala Leu
225 230 235 240
Trp Val Leu His Lys Arg Thr Gly Asp Asp Arg Ser Arg Pro Cys Asp
245 250 255
Leu Leu Leu Gly Lys Val Arg Asp Gly His His Gly Arg Lys Thr Gly
260 265 270
Arg Gly Phe Tyr Asp Tyr Glu Glu Val Phe Arg
275 280
<210> 70
<211> 852
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 70
atggcgcacc ggatcctcgt gctcggcgcg ggagtgatgg gcaccggcat caccacgctc 60
gcgctgcgcc acggcgtcca cgtgacgctc gtcgacacct ccgacgcgat cctcgtggcg 120
gcgcggacgc ggatagccgc cgagctgcgg atggcacagc tcgtggccgg gcccgccgag 180
gccgaccccg gcgtccttga gacgacgacg tcggtgctgc ccgcgatcgg catggccgac 240
gcggtgatcg aagccgtcgt cgaggacgcc gtggtcaagg cggacgtgct cgccacggtc 300
tcggcggcgg cgccgcccgg caccccgatc atcaccaaca cgtcgtcgat cccggtcgac 360
gagctggccg acgccgtggc acggccggag aacctgctcg gcacgcactt catgaacccg 420
tcgtacgtga tccccacggt cgaggtgatc cgcgggcccc gcagcggcga accggccatg 480
gccgccgtcg cggacctcct cgcggtgctc ggccgcaagc cgatcgtcgt ccgggacgcg 540
cccggcttcg tcacgagccg gttgctccat ccgatgatca acgacgcggc gcggatcgtg 600
caggagggca ccgcctccac cgaggacgtc gacgcgctca tgacgggctg cctcggccat 660
ccgacagggc cgctgcgcac cgcggacctg atcggcatcg acaacctcgt cgacgcgctg 720
tgggtgttgc acaagcgcac cggcgacgac cgcagccgcc cctgcgacct gctgctcggc 780
aaggtccgcg acgggcacca cggccggaag accgggcgtg gcttctacga ctacgaagag 840
gtgttccggt ga 852
<210> 71
<211> 86
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 71
Val Thr Val Pro Val Lys Asp Asp Pro Val Ala Arg Glu Leu Val Ala
1 5 10 15
Phe Leu Glu Thr Lys Thr Arg Ser Asp Trp Ser Val Glu Arg Asp Leu
20 25 30
Phe Ala Glu Gly Gly Leu Ser Ser Leu Phe Ala Leu Glu Leu Val Val
35 40 45
Phe Leu Glu Lys Thr Phe Gly Val Glu Ile Gly Gly Pro Asp Leu Gln
50 55 60
Leu Val Asn Phe Arg Thr Val Val Ser Met Val Glu Leu Val His Arg
65 70 75 80
Leu Arg Gly Glu Gly Ala
85
<210> 72
<211> 261
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 72
gtgacagtcc ccgtcaagga cgatcccgtc gcgcgtgagc tggtcgcgtt cctggagacg 60
aagaccaggt cggactggtc ggtggagcgc gacctgttcg cggagggcgg cctgtcgtcg 120
ctgttcgcgc tggagttggt ggtgttcctg gagaagacgt tcggcgtgga gatcgggggc 180
ccggaccttc agttggtgaa cttccggacc gtcgtgtcca tggtcgaact cgtccaccgg 240
ctgcggggcg agggtgcctg a 261
<210> 73
<211> 345
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 73
Met Gln Thr Lys Ile Leu Arg Gln Arg Asp Ile Lys Gln Ile Leu Ser
1 5 10 15
Val Val Gly Arg Asp Ala Ile Met Asp Arg Leu Ile Asp Asp Leu His
20 25 30
Asn Gly Phe Ala Ala Leu Gly Arg Gly Glu Leu Ala Glu Ala Pro Pro
35 40 45
Arg Ser Gly Phe Ala Arg Gly Gly Glu Val Pro Gly Val Ile Glu Phe
50 55 60
Met Pro Tyr Arg Val Pro Gly Val Ala Val Thr Met Lys Thr Ile Ser
65 70 75 80
Tyr Ser Pro His Asn Tyr Arg Arg Phe Arg Leu Pro Thr Val Val Gly
85 90 95
Thr Val Ser Arg Leu Asp Asp Asp Ser Gly Ser Leu Ile Ala Phe Ala
100 105 110
Asp Ala Ala Val Ile Thr Ala Met Arg Thr Gly Ala Val Ser Ala Ile
115 120 125
Ala Ser Arg Leu Leu Ala Arg Pro Asp Ser Ala Thr Leu Ala Leu Ile
130 135 140
Gly Ala Gly Ala Gln Ala Val Thr Gln Ala His Ala Leu Ser Arg Val
145 150 155 160
Leu Pro Ile Glu Arg Ile Leu Val Ser Asp Thr Asp Pro Asp His Ala
165 170 175
Glu Ser Phe Ala Gly Arg Val Ala Phe Leu Gly Leu Thr Val Asp Val
180 185 190
Thr Gly Pro Ala Ala Ala Val Ala Ala Ala Asp Val Leu Ser Thr Val
195 200 205
Thr Ser Val Pro Ala Gly Glu Gly Pro Val Leu Pro Ala Gly Pro Arg
210 215 220
Leu Pro His Leu His Val Asn Ala Thr Gly Ala Asp Glu Pro Gly Lys
225 230 235 240
Thr Glu Leu Pro Arg Pro Leu Leu Asp Asp Ala Phe Ile Cys Val Asp
245 250 255
His Pro Gly Gln Ala Arg Ala Glu Gly Glu Phe Gln Gln Leu Pro Asp
260 265 270
Arg Asp Leu Gly Pro Ser Leu Ala Ser Leu Cys Ala Ala Pro Ser Ser
275 280 285
Ala Thr Ala His Val Asp Ser Leu Ser Val Leu Asp Ser Thr Gly Ser
290 295 300
Ala Phe Ala Asp His Ile Ala Phe Asp Val Leu Leu Gly Phe Ala Asp
305 310 315 320
Glu Leu Gly Leu Gly Arg Lys Ala Ala Ile Gly Ala Ala Pro Glu Asp
325 330 335
Val Leu Asp Pro Tyr Ser Leu Pro Trp
340 345
<210> 74
<211> 1038
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 74
atgcagacca agatcctgcg gcagcgcgac atcaagcaga ttctctccgt ggtcggccgc 60
gacgcgatca tggaccggct gatcgacgac ctgcacaacg gcttcgccgc actgggccgt 120
ggagagctcg ccgaggcgcc accacgcagt ggattcgccc gcggcggcga agtgcccggc 180
gtcatcgagt tcatgccgta ccgggtgccc ggtgtcgccg tgaccatgaa gacgatctcg 240
tacagtccgc acaactaccg gcgattccgg ctgccgacgg tcgtcggtac ggtgtcgcgc 300
ctggacgacg acagcgggag cctgatcgcg ttcgccgacg cggccgtgat caccgcgatg 360
cggaccggcg cggtctcggc gatcgcgagc cgactcctcg ccaggcccga cagcgccacg 420
ctcgcactga tcggcgcggg cgcgcaggcg gtgacccagg cgcacgcgct cagcagggtc 480
ctgccgatcg agcggatcct ggtcagcgac accgacccgg accacgcgga gtccttcgcg 540
ggccgcgtcg cgttcctcgg cctcacggtt gatgtcaccg gtcccgcggc ggcggtcgcc 600
gccgcggacg tcctgagcac cgtcacctcg gtgcccgcgg gcgaaggccc cgtgctgcct 660
gccgggccgc gactgccgca cctgcacgtg aacgcgacgg gcgccgacga gccgggcaag 720
accgagttgc cgagacctct gctggacgac gcgttcatct gcgtcgacca ccccggacag 780
gcccgcgcgg aaggcgagtt ccagcaactg ccggaccgtg accttggccc gtccctcgcg 840
agcttgtgcg cggcgccgag cagcgcgacg gcgcacgtcg acagcctgag cgtcctcgac 900
tccaccggca gcgcgttcgc cgaccacatc gcgttcgacg tgctgctcgg cttcgcggac 960
gagctcggtc tcggccgaaa ggccgcgatc ggagcggcgc cggaggacgt actcgacccg 1020
tactcgctgc cgtggtga 1038
<210> 75
<211> 3597
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 75
Met Ala Gly Asn Asp Leu Ile Asp Ala Leu Arg Thr Ser Val Lys Asp
1 5 10 15
Asn Ala Lys Leu Arg Arg Glu Asn Thr Ala Leu Arg Ala Ala Ala Asn
20 25 30
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
35 40 45
Thr Ser Pro Glu Glu Leu Trp Glu Leu Val Glu Asp Gly Gly Asp Ala
50 55 60
Val Gly Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Ala Ala Leu His
65 70 75 80
Ala Ala Ala Glu Ser Ala Thr Ser Arg Ala Gly Ala Leu Met Gly Ala
85 90 95
Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Thr
100 105 110
Ala Leu Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala Trp Glu Ala
115 120 125
Ile Glu Arg Ala Gly Ile Lys Ala Asp Val Leu Arg Gly Thr Asp Thr
130 135 140
Gly Val Phe Val Gly Gly Phe Tyr Tyr Gly Tyr Gly Ala Gly Ala Asp
145 150 155 160
Leu Gly Gly Phe Gly Ala Tyr Ser Thr Gln Pro Ala Val Leu Ala Gly
165 170 175
Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp
180 185 190
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ala
195 200 205
Leu Arg Ala Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val
210 215 220
Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln Gly Gly Val
225 230 235 240
Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr
245 250 255
Gly Phe Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp
260 265 270
Ala Glu Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala
275 280 285
Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser Ala Pro Asn Gly Pro
290 295 300
Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Gly Ser Ala Gly Leu Ala
305 310 315 320
Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu
325 330 335
Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly
340 345 350
Arg Glu Val Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
355 360 365
Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala
370 375 380
Met Arg Arg Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser
385 390 395 400
Ser His Val Asp Trp Thr Thr Gly Ala Val Glu Leu Leu Thr Glu Ala
405 410 415
Arg Pro Trp Pro Glu Ser Asp Arg Pro Arg Arg Ala Gly Val Ser Ala
420 425 430
Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Val Ala
435 440 445
Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly Leu Val Pro Leu Pro
450 455 460
Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val Gln Val Glu Arg Leu
465 470 475 480
Gly Ala Tyr Val Arg Ser Gly Ala Asp Leu Ser Ala Val Ala Asp Gly
485 490 495
Leu Val Arg Glu Arg Val Val Phe Gly His Arg Ala Val Leu Leu Gly
500 505 510
Glu Ser Thr Val Ala Gly Val Ala Glu Gly Glu Leu Arg Thr Val Phe
515 520 525
Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu
530 535 540
Met Gly Ala Ser Glu Val Phe Ala Ala Arg Met Arg Glu Cys Ala Ala
545 550 555 560
Ala Leu Glu Pro His Thr Gly Trp Asp Leu Leu Asp Val Leu Gly Glu
565 570 575
Ala Val Val Ala Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala
580 585 590
Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala His Gly Gly Thr Pro
595 600 605
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Ser Val
610 615 620
Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Ile Val Ala Leu Arg
625 630 635 640
Ser Gln Thr Ile Ala Ala Arg Leu Ala Gly Arg Gly Ala Met Ala Ser
645 650 655
Ile Ala Ile Pro Ser Ala Glu Val Glu Val Met Glu Gly Val Trp Val
660 665 670
Ala Ala Arg Asn Gly Pro Ser Ser Thr Val Ile Ala Gly Asp Pro Ala
675 680 685
Ala Val Glu Gln Val Leu Ala Arg Tyr Glu Ala Glu Gly Val Arg Val
690 695 700
Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala
705 710 715 720
Ile Gln Asp Glu Leu Ala Glu Val Leu Glu Gly Val Thr Ala Gln Val
725 730 735
Pro Thr Ile Pro Trp Trp Ser Thr Val Asp Ser Asp Trp Val Thr Glu
740 745 750
Pro Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala
755 760 765
Met Asp Thr Ala Ile Gly Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys
770 775 780
Ser Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Glu Arg Thr Val
785 790 795 800
Ala Ser Leu Arg Thr Asp Asp Gly Gly Trp Glu Arg Phe Leu Thr Ala
805 810 815
Leu Ala Glu Ala Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Ile Leu
820 825 830
Val Glu Pro Ala Pro His Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe
835 840 845
Asp His Lys Arg Tyr Trp Leu Leu Pro Ala Pro Glu Gly Gly Ala Gly
850 855 860
Ile Gly His Pro Phe Leu Ser Ser Ala Ala Val Leu Pro Gly Ser Asp
865 870 875 880
Gly Val Leu Leu Thr Gly Lys Leu Ser Leu Ala Thr His Pro Trp Leu
885 890 895
Ala Asp His Ala Val Gln Asp Met Val Leu Leu Pro Gly Thr Ala Phe
900 905 910
Leu Glu Leu Val Val Arg Ala Gly Asp Glu Val Gly Cys Asp Thr Ile
915 920 925
Asp Glu Leu Val Ile Glu Thr Pro Leu Val Leu Pro Val Thr Gly Ala
930 935 940
Val Asp Leu Thr Val Thr Val Asp Gln Pro Asp Asp Thr Gly Cys Arg
945 950 955 960
Pro Val Ser Val His Ala Arg Pro Glu Gly Thr Asp Thr Trp Thr Arg
965 970 975
His Ala Thr Gly Thr Leu Gly Arg Ala Gly Asn Thr Val Ala Ala Pro
980 985 990
Ser Ser Ala Trp Pro Pro Pro Gly Ala Gln Pro Val Asp Val Thr Gly
995 1000 1005
Phe Tyr Glu Arg Leu Ala Glu Thr Gly Tyr Leu Tyr Gly Pro Ala
1010 1015 1020
Phe Arg Gly Leu Arg Ala Ala Trp Arg Ala Gly Glu Thr Leu Tyr
1025 1030 1035
Ala Glu Val Glu Ile Ala Ala Glu Gln Ala Asp Asp Thr Ser Arg
1040 1045 1050
Tyr Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu His Val Thr
1055 1060 1065
Cys Leu Pro Pro Leu Thr Gly Gln Asp Ser Asp Ser Ala Ser Glu
1070 1075 1080
Val Lys Leu Pro Phe Ser Trp Asn Gly Val Arg Phe His Thr Thr
1085 1090 1095
Gly Ala Thr Thr Leu Arg Val Ala Ile Thr Pro Gly Pro His Gly
1100 1105 1110
Val Ala Val His Ala Ala Asp Pro Ala Gly His Pro Val Val Thr
1115 1120 1125
Val Ser Glu Leu Thr Ala Arg Pro Val Asn Val Ser Thr Asp Ala
1130 1135 1140
Asp Thr Asp Ala Ala Val Arg Asn Ser Leu Tyr Asp Leu Ser Trp
1145 1150 1155
Thr Glu Leu Pro Thr Pro Ala Ser Thr Pro Gly Pro Ala Asp Ala
1160 1165 1170
Val Gln Val Val Ser Ala Val Pro Asp Pro Gly Ala Asp Val Leu
1175 1180 1185
Asp Glu Thr Tyr Arg Leu Ser Glu Leu Val Leu Ala Glu Leu His
1190 1195 1200
Arg Val Ile Ala Asp Asp Ser Leu Ala Glu Thr Thr Ile Val Val
1205 1210 1215
Arg Val Asp Ala Gly Pro Thr Gly Gly Ala Val Ala Gly Leu Val
1220 1225 1230
Arg Ser Ala Gln Ala Glu His Pro Gly Arg Phe Val Leu Val Glu
1235 1240 1245
Thr Gly Ala Asp Thr Ser Val Glu Ala Met Ala Ala Ala Thr Thr
1250 1255 1260
Leu Ala Glu Pro Tyr Val Arg Val Thr Asp Gly Arg Tyr Glu Ala
1265 1270 1275
Pro Arg Leu Thr Arg Ala Val Ala Thr Pro Pro Tyr Glu Pro Leu
1280 1285 1290
Leu Asp Pro Asp Gly Thr Val Val Ile Thr Gly Gly Ser Gly Val
1295 1300 1305
Leu Ala Gly Leu Leu Ala Arg Arg Leu Val Ala Glu His Gly Ala
1310 1315 1320
Arg His Leu Leu Leu Leu Ser Arg Ser Glu Pro Pro Ala Asp Thr
1325 1330 1335
Pro Gly Val His Val Arg Cys Asp Val Ser Asp Arg Asp Gln Leu
1340 1345 1350
Ala Ala Ala Leu Ala Ala Val Asp Arg Pro Leu Thr Ala Val Phe
1355 1360 1365
His Thr Ala Ala Ala Leu Asp Asp Gly Val Val Ala Ala Leu Thr
1370 1375 1380
Pro Glu Arg Leu Ala Thr Thr Leu Arg Pro Lys Ala Asp Gly Ala
1385 1390 1395
Trp His Leu His Glu Leu Thr Arg Gly Ala Asp Leu Arg Ala Phe
1400 1405 1410
Val Leu Tyr Ser Ser Val Ala Gly Ile Leu Gly Gly Arg Gly Gln
1415 1420 1425
Ala Asn Tyr Ala Ala Ala Asn Gly Phe Leu Asp Gly Leu Ala Ala
1430 1435 1440
Gln Arg Arg Ala Glu Gly Leu Pro Ala Leu Ser Leu Ala Trp Gly
1445 1450 1455
Leu Trp Ala Asp Asp Ser Gly Leu Thr Gly Gly Met Ser Asp Thr
1460 1465 1470
Asn Arg Thr Arg Val Arg Arg Gly Gly Phe Arg Pro Met Gln Ala
1475 1480 1485
Gly Leu Ala Leu Arg Leu Leu Glu Thr Ala Ala Gly Ser Asp Ala
1490 1495 1500
Ala Phe Ala Val Ala Ala Ile Met Asp Leu Arg Glu Gln Thr Ser
1505 1510 1515
Pro Leu Leu Ala Ser Leu Arg Arg Ser Val Pro Arg Gly Ala Ala
1520 1525 1530
Ala Thr Thr Val Pro Leu Ala Glu Arg Leu Gly Ala Met Thr Gly
1535 1540 1545
Ala Asp Arg Asp Ala Ala Leu Leu Thr Leu Val Arg Asp Cys Ala
1550 1555 1560
Ala Ala Val Leu Gly His Val Asp Ala Ala Gly Val Pro Ala Asp
1565 1570 1575
Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
1580 1585 1590
Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Val Arg Leu Pro Ala
1595 1600 1605
Thr Leu Ala Phe Asp His Pro Thr Pro Arg Ala Ile Ala Ser Arg
1610 1615 1620
Leu Asp Glu Ala Leu Val Gly Gly Ala Val Pro Ala Ala Val Pro
1625 1630 1635
Ala Ala Ala Ala Ser Arg Asp Glu Pro Leu Ala Ile Val Gly Met
1640 1645 1650
Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro Gly Asp Leu Trp
1655 1660 1665
Gln Met Leu Asp Ser Gly Gly Asp Ala Val Thr Gly Phe Pro Val
1670 1675 1680
Asp Arg Gly Trp Asp Pro Ser Gly Leu Thr Gly Gly Pro Asp Ala
1685 1690 1695
Asp Arg Gly Gly Phe Leu Ser Asp Ala Ala Asp Phe Asp Ala Ala
1700 1705 1710
Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln
1715 1720 1725
Gln Arg Ile Leu Leu Glu Thr Thr Trp Glu Ala Phe Glu Asn Ala
1730 1735 1740
Gly Ile Val Pro Gly Thr Leu Arg Gly Ser Asp Thr Gly Val Phe
1745 1750 1755
Met Gly Ala Phe Ser Tyr Gly Tyr Gly Val Gly Ala Asp Leu Gly
1760 1765 1770
Gly Phe Gly Ser Ile Gly Val Gln Pro Ser Val Leu Thr Gly Arg
1775 1780 1785
Ile Ser Tyr Phe Tyr Gly Leu Gln Gly Pro Ala Phe Thr Val Asp
1790 1795 1800
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly His
1805 1810 1815
Ala Leu Arg His Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
1820 1825 1830
Thr Val Met Ala Asn Pro Asp Gly Phe Val Glu Phe Glu Gln Gln
1835 1840 1845
Gly Gly Leu Ser Pro Asp Gly Arg Cys Arg Ala Phe Ala Asp Ala
1850 1855 1860
Ala Asn Gly Thr Gly Trp Ala Glu Gly Ala Gly Val Leu Val Val
1865 1870 1875
Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala
1880 1885 1890
Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
1895 1900 1905
Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
1910 1915 1920
Ala Leu Ala Asn Ala Gly Leu Gly Ala Ala Asp Val Asp Val Val
1925 1930 1935
Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp Pro Ile Glu Ala
1940 1945 1950
Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly Arg Glu Val Pro Leu
1955 1960 1965
Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala
1970 1975 1980
Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Met Arg Arg
1985 1990 1995
Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Ser His
2000 2005 2010
Val Asp Trp Thr Ala Gly Ala Val Glu Val Val Thr Glu Ala Arg
2015 2020 2025
Pro Trp Pro Glu Ser Gly Arg Val Pro Arg Ala Gly Val Ser Ser
2030 2035 2040
Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu Glu Gly Ala
2045 2050 2055
Pro Glu Pro Ser Ser Gly Ala Glu Ala Ser Ser Gly Gly Gly Leu
2060 2065 2070
Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val
2075 2080 2085
Gln Val Glu Arg Leu Gly Ala Tyr Val Arg Gly Gly Ala Asp Leu
2090 2095 2100
Gly Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Asp
2105 2110 2115
Arg Arg Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala
2120 2125 2130
Val Glu Gly Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser
2135 2140 2145
Gln Trp Val Gly Met Gly Arg Glu Leu Met Gly Val Ser Glu Val
2150 2155 2160
Phe Ala Ala Arg Met Arg Glu Cys Ala Ala Ala Leu Glu Pro Tyr
2165 2170 2175
Thr Gly Trp Asp Val Leu Asp Val Leu Gly Glu Ala Val Val Ala
2180 2185 2190
Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala Val Ala Val
2195 2200 2205
Ser Leu Ala Ala Leu Trp Gln Ala His Gly Val Val Pro Asp Ala
2210 2215 2220
Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
2225 2230 2235
Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Val Val Ala Leu Arg
2240 2245 2250
Ser Gln Thr Ile Ala Ala Arg Leu Ala Gly His Gly Ala Met Ala
2255 2260 2265
Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Met Glu Gly Val
2270 2275 2280
Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala Gly
2285 2290 2295
Asp Pro Ala Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala
2300 2305 2310
Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr
2315 2320 2325
Pro His Val Glu Ala Ile Gln Asp Glu Leu Ala Asp Val Leu Gly
2330 2335 2340
Gly Ile Thr Ser Ser Ala Pro Asp Ile Ser Trp Trp Ser Thr Val
2345 2350 2355
Asp Ser Gly Trp Val Thr Glu Ala Val Gly Asp Asp Tyr Trp Tyr
2360 2365 2370
Arg Asn Leu Arg Gln Pro Val Ala Met Asp Thr Ala Val Ser Glu
2375 2380 2385
Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser Ala His Pro Val Leu
2390 2395 2400
Leu Pro Ala Leu Asp Gln Glu Arg Thr Val Ala Ser Leu Arg Thr
2405 2410 2415
Asp Asp Gly Gly Trp Asp Arg Phe Leu Thr Ala Leu Ala Gln Ala
2420 2425 2430
Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Thr Leu Ile Glu Pro
2435 2440 2445
Ala Gln His Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe Asp His
2450 2455 2460
Lys Arg Tyr Trp Leu Gln Pro Ala Pro Val Gly Gly Ala Gly Ile
2465 2470 2475
Gly His Pro Phe Leu Ser Ser Ala Ala Val Leu Pro Gly Ser Asp
2480 2485 2490
Gly Val Leu Leu Thr Gly Arg Ile Ser Leu Arg Thr His Pro Trp
2495 2500 2505
Leu Ala Asp His Thr Val Gln Asp Thr Val Leu Leu Pro Gly Thr
2510 2515 2520
Ala Leu Leu Glu Leu Val Val Arg Ala Gly Asp Glu Val Gly Cys
2525 2530 2535
Asp Thr Ile Asp Glu Leu Val Ile Glu Thr Pro Leu Thr Leu Pro
2540 2545 2550
Val Thr Gly Ala Ala Asp Leu Thr Val Thr Val Asp Gln Pro Asp
2555 2560 2565
Thr Thr Gly Arg Arg Pro Val Ser Val His Ala Arg Pro Glu Gly
2570 2575 2580
Thr Asp Thr Trp Thr Arg His Ala Thr Gly Thr Leu Thr Thr Asn
2585 2590 2595
Ile Gly Pro Asp Pro Thr His Pro Asp Ser Ser Thr Asp Thr Phe
2600 2605 2610
Leu Gln Trp Pro Pro Pro Asn Ala Gln Pro Val Asp Val Thr Thr
2615 2620 2625
Phe Tyr Asp Glu Leu Ala Asp Ala Gly Tyr Gly Tyr Gly Pro Ala
2630 2635 2640
Phe Gln Gly Leu Arg Ala Ala Arg Gln Asp Gly Asp Thr Val Tyr
2645 2650 2655
Ala Asp Val Thr Leu Ser Asp Glu Gln Ala Ala Glu Ala Thr Arg
2660 2665 2670
Tyr Ala Leu His Pro Ala Leu Leu Asp Ala Ala Leu Gln Ala Val
2675 2680 2685
Ala Phe Thr Val Pro Asp Asp Ser Ala Pro Gly Leu Pro Phe Ala
2690 2695 2700
Trp Thr Gly Ala Arg Phe Val Ser Ala Gly Pro Thr Thr Leu Arg
2705 2710 2715
Val Val Ile Thr Arg Asp Gly Asp Glu Leu Ser Leu Arg Ala Ala
2720 2725 2730
Asp Ser Thr Gly Gln Leu Val Ala Glu Ile Arg Thr Ile Arg Thr
2735 2740 2745
Arg Pro Leu Ser Pro Pro Ala Asp Thr Gly Leu Met Arg Leu Ala
2750 2755 2760
Trp Thr Glu Val Ala Val Pro Val Asp Val Pro Thr Gly Asp Val
2765 2770 2775
Asp Val Ile Thr Leu His Ala Ala Ala Asp Asp Asp Pro Thr Ala
2780 2785 2790
Glu Thr Arg Ala Leu Thr Ala His Leu Leu Ala Ala Leu Thr Gly
2795 2800 2805
Thr Asp Gln Thr Leu Leu Val His Thr Thr Glu Gly Leu Ala Thr
2810 2815 2820
Ala Ala Ala Ala Gly Leu Leu Arg Ala Ala Gln Ala Glu Gln Pro
2825 2830 2835
Gly Arg Phe Val His Val Glu Thr Ala Pro Gly Val Thr Leu Glu
2840 2845 2850
Pro Glu Gln Gln Arg Ile Ala Val Ala Leu Asp Glu Pro Arg Leu
2855 2860 2865
Arg Leu Arg Arg Gly Arg Phe Glu Ala Ala Arg Leu Thr Arg Val
2870 2875 2880
Pro Glu Pro Leu Ile Val Pro Glu Ser Asp Thr Trp Leu Ile Arg
2885 2890 2895
Pro Ala Pro Thr Gly Thr Leu Asp Gly Leu Thr Ala Ala Asp Ser
2900 2905 2910
Ala Glu Pro Trp Arg Pro Leu Ala Pro Thr Glu Val Arg Ile Gly
2915 2920 2925
Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu
2930 2935 2940
Gly Thr Tyr Pro Gly Arg Gly Val Leu Gly Gly Glu Ala Ala Gly
2945 2950 2955
Val Val Leu Glu Thr Gly Ala Asp Val Ser Gly Leu Thr Ala Gly
2960 2965 2970
Asp Arg Val Phe Gly Leu Val Gly Thr Gly Phe Gly Pro Thr Val
2975 2980 2985
Ile Ala Asp His Arg Met Leu Gly Arg Met Pro Asp Asp Trp Thr
2990 2995 3000
Phe Pro Gln Ala Ala Ser Val Val Thr Val Phe Ala Thr Ala Trp
3005 3010 3015
Tyr Gly Leu Val Asp Leu Ala Lys Leu Arg Pro Gly Glu Gln Val
3020 3025 3030
Leu Ile His Ala Ala Ala Thr Gly Val Gly Ala Ala Ala Val Gln
3035 3040 3045
Ile Ala Arg His Leu Gly Ala Asp Val Tyr Ala Thr Ala Ser Thr
3050 3055 3060
Pro Lys Gln His Leu Val Asp Leu Ala Pro Thr His Ile Ala Asp
3065 3070 3075
Ser Arg Ser Thr Ala Phe Ala Asp Thr Phe Pro Pro Val Asp Val
3080 3085 3090
Val Leu Asn Ser Leu Thr Gly Glu Leu Leu Asp Thr Ser Thr Ala
3095 3100 3105
Leu Leu Ala Pro Gly Gly Arg Phe Ile Glu Met Gly Lys Thr Asp
3110 3115 3120
Ile Arg His His Ala Gln Gln Pro Phe Asp Leu Met Asp Ala Gly
3125 3130 3135
Pro Asp Arg Leu Gln Gln Ile Ile Thr Gln Leu Leu Asp Leu Phe
3140 3145 3150
Ala Asn Gly Thr Leu His Pro Leu Pro Val Met Val His Asp Ile
3155 3160 3165
Arg Gln Ala Arg Asp Ala Leu Ala Thr Met Ser Arg Gly Glu His
3170 3175 3180
Val Gly Lys Leu Val Leu Thr Val Pro Arg Pro Leu Asp Pro Glu
3185 3190 3195
Gly Ala Val Ile Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile
3200 3205 3210
Leu Ala Arg His Leu Asn His Pro His Thr Tyr Leu Leu Ser Arg
3215 3220 3225
Thr Pro Pro Pro Asp Thr Thr Pro Gly Thr His Leu Pro Cys Asp
3230 3235 3240
Val Ser Asp Pro Thr Gln Leu Ala Thr Ala Leu Ala Gln Ile Pro
3245 3250 3255
Glu Pro Leu Thr Gly Val Phe His Thr Ala Ala Ala Leu Asp Asp
3260 3265 3270
Ala Leu Leu Asp Asn Leu Thr Pro Gln Arg Ile Asp Thr Val Leu
3275 3280 3285
Gln Pro Lys Ala Asp Ala Ala Trp His Leu His His His Thr His
3290 3295 3300
Thr His Ala Thr Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser Ala
3305 3310 3315
Ala Gly Val Leu Gly Thr Pro Gly Gln Gly Asn Tyr Ala Ala Ala
3320 3325 3330
Asn Ala Phe Leu Asp Ala Leu Ala Glu His Arg Arg Thr Gln Gly
3335 3340 3345
Leu Pro Gly Leu Ser Ile Ala Trp Gly Leu Trp Asp Gln Ala Ser
3350 3355 3360
Gly Leu Thr Gly Glu Leu Thr Asp Ala Asp Arg Arg Arg Met Arg
3365 3370 3375
Gln Gly Gly Ala Arg Ala Leu Thr Ala Glu Gln Gly Met Arg Met
3380 3385 3390
Tyr Asp Ala Ala Val His Ala Gly Thr Gly Ser Val Val Ala Val
3395 3400 3405
Ala Gly Glu Leu Pro Ser Asp Ile Pro Leu Leu Arg Gly Arg Arg
3410 3415 3420
Lys Pro Val Ala Arg Arg Gly Ala Arg Asn Glu Val Ala Arg His
3425 3430 3435
Thr Asp Leu Leu Thr Leu Val Arg Gln Lys Ala Ala Ala Leu Leu
3440 3445 3450
Gly His Ala Gly Pro Glu Asp Val Pro Glu Asp Ala Ala Phe Arg
3455 3460 3465
Gln Leu Gly Val Asp Ser Leu Ile Ala Val Gln Leu Arg Asn Gly
3470 3475 3480
Leu Asn Glu Ala Thr Gly Leu Arg Leu Ser Ala Thr Leu Val Phe
3485 3490 3495
Asp Tyr Pro Thr Pro Arg Ala Leu Ala Gly Arg Ile Gly Glu Leu
3500 3505 3510
Leu Ser Pro Asp Asp Pro Ala Ala Ala Val Leu Ala Gln Leu Asp
3515 3520 3525
Arg Leu Glu Glu Leu Val Ala Asp Val Asp Pro Gly Asp Arg Arg
3530 3535 3540
Asn Asp Ser Ile Gly Pro Arg Ile Gly Ala Leu Phe Glu Arg Trp
3545 3550 3555
Gln Arg Val Gly Arg Pro Ala Val Pro Ala Asp Val Leu Ser Glu
3560 3565 3570
Asp Ala Thr Ala Asp Glu Ile Phe Asp Leu Ile Asp Arg Glu Leu
3575 3580 3585
Arg Thr Ala Pro Thr Lys Lys Gly Arg
3590 3595
<210> 76
<211> 10794
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 76
atggctggaa acgacctgat cgacgcgctg cggacgtcgg tcaaggacaa cgcgaaactg 60
cgcagggaga acaccgcgct gcgcgccgcc gcgaacgagc cgctcgccgt cgtcgggatg 120
gcgtgccgcc tgcccggcgg catcacgtcc ccggaagagc tgtgggagct cgtcgaggac 180
ggcggtgacg cggtcggcga cttccccacc gaccggggct gggacgtggc cgcactacac 240
gccgccgccg agtccgcgac gtcgagggcg ggtgcgctca tgggcgccgc cgacttcgac 300
gccgcgttct tcggcatcag cccgcgggag gccaccgcgc tcgacccgca gcagcggatc 360
cttctcgaga tcgcctggga ggccatcgaa cgcgcgggta tcaaggcgga cgtgctgcgc 420
ggcaccgaca caggagtgtt cgtcggcggc ttctactacg gctacggcgc cggtgcggac 480
ctgggtggct tcggcgccta cagcacacag cccgcggtcc ttgcgggccg cctctcatac 540
ttcttcggac tcgaaggccc cgccgtcacc gtcgacacgg cgtgctcgtc gtccctggtc 600
gccctgcacc aggccggtca ggcactgcgc gcgggcgagt gctccctcgc gctcgtcggc 660
ggtgtcacgg tgatggcgtc gccgcagagc ttcgtggagt tctcccggca gggcggcgtg 720
gccccggacg ggcggtgcaa ggcgttcgcc gacgcggcgg acggcaccgg gttcgccgag 780
ggcgccggtg tcctggtcgt ggaacggctg tccgacgcgg agcgcaacgg tcacaccgtt 840
ctcgcggtcg tacgcggctc ggcggtgaac caggacggcg cgtccaacgg catctccgca 900
ccgaacggcc cggcccagca acgggtgatc cgtcaggcac tcggaagtgc gggactcgct 960
ccagccgacg tcgacgtggt ggaggcgcac gggacgggaa cggtcctcgg cgatccgatc 1020
gaggcgcagg cggttctggc gacgtatggg cagggtcgtg aagttccgtt gttgttgggt 1080
tcgttgaagt cgaacatcgg tcatgcgcag gcggcggcgg gtgttgccgg tgtcatcaag 1140
atggtgatgg cgatgcggcg tggggtggtg ccgcggacgt tgcatgtgga tgagccgtcg 1200
tcacacgtgg actggacgac cggggcggtt gagctgctca cggaggcgag gccgtggccg 1260
gagtcggacc gcccgcgccg ggccggtgtg tccgcgttcg gggtgagtgg cacgaatgcg 1320
catgtgattt tggaggaggt tgcggagtcg tcggttcgta gcggggggtc gtcgggtctg 1380
gtgccgttgc cggtgtcggc gcgtacggag tcgagcctgg cggtccaggt ggagcggctg 1440
ggtgcgtacg tgcggagtgg ggcggacctc agcgcggtgg cggatggcct ggtccgtgag 1500
cgggtggtct tcggccatcg ggcggtgttg ctgggggaga gcacggttgc cggggtggct 1560
gagggcgagc tgcggacggt gttcgtgttc ccggggcagg gctcgcaatg ggtgggcatg 1620
ggccgggagt tgatgggcgc ctcggaggtg ttcgcggcgc ggatgcggga gtgtgcggcg 1680
gcgctggagc cgcataccgg ctgggatttg ctggatgtgc tgggcgaggc ggtggtggct 1740
gatcgggtgg aggtgttgca gcccgcgtcg tgggcggtgg cggtgagcct ggccgcactg 1800
tggcaggccc acgggggcac tccggatgcg gtgatcgggc attcgcaggg ggagatcgcc 1860
gcggcgagtg tggcgggggc cttgagtctg gaggacgctg cgcgaatcgt ggccttgcgc 1920
agccagacca tcgccgcgcg gctggccggt cgtggggcga tggcgtcaat tgccataccc 1980
tctgccgagg ttgaggtgat ggagggagtg tgggtcgcgg cccgcaacgg cccctcctcg 2040
actgtgatcg cgggcgatcc ggcggcggtg gagcaggtgc tggcccgcta cgaggccgag 2100
ggtgtgcggg tgcgccggat cgcggtggat tacgcctcgc acaccccgca cgtggaagcg 2160
atccaggacg agttggccga ggtcctggaa ggggtgacgg cccaagtccc cacaatccct 2220
tggtggtcga cggtcgacag cgactgggtg accgaaccgg tcgatgacga ctactggtac 2280
cgcaacctgc gtcagccggt ggcgatggac acggcgatcg gcgagctgga cggttcgctg 2340
ttcatcgagt gcagtgccca tccggtgctg ctgcccgcct tggaccagga gcgtacggtc 2400
gcttccctgc gtaccgatga cggtggctgg gagcggttcc tgaccgcgct cgccgaggcc 2460
tggacccagg gcgcggacgt cgactggacc atcctcgtcg agcccgcccc gcaccggttg 2520
ttggatctgc cgacctaccc cttcgaccac aagcggtact ggctgttgcc tgccccggag 2580
ggtggcgcgg ggatcgggca tccgttcctg tcgagtgcgg cggtgctgcc gggcagcgac 2640
ggcgtactac tcacgggcaa gctgtccctg gccacgcatc cgtggctggc cgatcacgcc 2700
gtgcaggaca tggtgttgct gccgggcacg gcgttcctcg aacttgtggt gcgggccggt 2760
gacgaggtcg gctgcgacac cattgacgaa ctggtcatcg agaccccgct cgtactgccc 2820
gtcaccggtg ccgtcgatct caccgtcact gtcgaccagc ccgacgacac cggatgccgc 2880
ccggtgagcg tccacgcacg ccccgaagga accgacacct ggacccgcca cgccaccggc 2940
acactcggcc gcgccggaaa caccgtggcg gccccctcgt ccgcgtggcc gccgcccggg 3000
gcacaacccg tcgacgtcac cggcttctac gagcggctcg ctgagaccgg ctacctctac 3060
ggcccggcat tccgcggcct gcgcgcggct tggcgcgcag gcgaaacctt gtacgccgag 3120
gtggagatcg ccgcggaaca ggcggacgac acgtcccgct acggcgtaca cccggccctg 3180
ctcgacgcgg cgctgcacgt cacctgcctg ccgccgctca cggggcagga ttcggactcg 3240
gcgtcggagg tgaagctgcc gttctcgtgg aacggcgtac ggttccacac gaccggcgcc 3300
accacgctgc gtgtcgcgat caccccgggc ccccatggcg tggccgtgca cgcggcggac 3360
ccggcaggcc accctgtggt gaccgtctcc gagttgaccg cgcggccggt gaacgtcagc 3420
accgacgccg acaccgacgc cgccgtccgt aactccctgt acgacctctc ctggaccgaa 3480
ctgcccactc ccgcctccac ccccggtccc gcggacgcgg tccaagtcgt ctcagcagtc 3540
ccggacccgg gcgcggacgt gctcgacgag acctaccggc tctccgagct cgtgctcgcc 3600
gagttgcacc gggtgatcgc cgacgacagc ctcgcggaga ccactatcgt cgtccgcgtc 3660
gacgcgggac cgaccggggg agcggtcgca ggactcgtcc ggtccgcgca ggccgagcat 3720
ccgggccgat tcgtgctcgt ggagaccggc gccgacacct ccgtcgaggc gatggccgcg 3780
gccacgacac tggccgagcc gtacgttcgc gtcaccgacg gccgatacga ggcgccccgg 3840
ctcacccggg cggtcgccac gccgccgtac gagccgttgc tcgacccgga cggcacggtg 3900
gtcatcaccg gcggctcggg cgtgctggcc ggtcttctcg cccggcggct cgtcgccgag 3960
cacggcgccc gccatctgtt gctgctgtcg cgcagcgagc cgccggcgga cacacccggc 4020
gtccacgtcc gctgtgacgt ctccgacagg gaccagctcg ccgccgcgct cgccgccgtg 4080
gatcggccgc tcacggcggt cttccacacg gcggcggcgc tcgatgacgg tgtggtcgcg 4140
gcgctcacgc cggagcggct cgccaccacg ctgcgcccca aggccgacgg cgcctggcat 4200
ctgcacgagc tgactcgcgg tgcggacctg cgcgcgttcg tcctctactc gtccgtcgcg 4260
ggcatcctcg gcggccgtgg ccaggccaac tacgcggcgg cgaacgggtt cctcgacgga 4320
ctcgccgcgc agcgccgtgc cgaggggctg cccgcgctgt cactggcctg gggactgtgg 4380
gccgacgaca gcggactcac cggcggcatg agcgacacga accggacccg cgtacgccgc 4440
ggtggtttcc gccccatgca agcaggcctg gccctacgcc tgttggagac cgcggccggt 4500
tccgatgccg cgttcgccgt ggcggccatc atggacctgc gcgaacagac gtcccccctc 4560
ctcgcgagct tgcgccgctc cgtgccgcgc ggggcggccg ccaccactgt cccgctcgcc 4620
gagcggctcg gcgccatgac cggcgccgac cgggatgccg cgctgctcac cctggtccgc 4680
gactgcgcgg cggcggtgct gggccacgtg gacgccgcgg gcgtcccggc ggacgcggcg 4740
ttcaaggacc ttggtgtcga ctcgttgacc gccgtcgagc tgcggaaccg gctcgccgcg 4800
gcgaccggcg tccgactgcc cgccacgctc gccttcgacc atccgacacc gagggccatc 4860
gcgtcacggc tggacgaggc gctggtcggc ggcgcagtcc cggccgcggt tccggcggcc 4920
gccgcgtccc gcgacgagcc cctcgcgatc gtcggcatgg cctgccgcct gcccggcggc 4980
gtcgcctccc cgggtgacct gtggcagatg ctggacagtg gcggcgacgc ggtcaccggc 5040
ttcccggtcg accgcggctg ggacccttcg ggcctcaccg gcggaccgga cgcggatcgc 5100
ggcggtttcc tctccgacgc cgccgacttc gacgccgcgt tcttcgggat cagtccgcgc 5160
gaggcgctgg ccatggaccc gcagcagcgg atcctgctgg agacgacgtg ggaggcgttc 5220
gagaacgcgg gcatcgtgcc gggcacgctg cgcggaagcg acaccggcgt gttcatgggg 5280
gccttctcct acgggtacgg cgtcggcgcc gacctgggcg ggttcggctc gatcggcgtg 5340
cagcccagcg tcctcaccgg ccggatctcg tacttctacg ggctccaggg cccggcgttc 5400
accgtcgaca cggcgtgctc gtcatcgctc gtcgcgctgc accaggcggg gcacgccctg 5460
cgccacggtg agtgctcgct cgcgctggtc ggcggtgtca ccgtcatggc gaacccggac 5520
ggattcgtcg agttcgaaca gcagggcggg ctctctcccg acggccgctg ccgcgcgttc 5580
gcggacgccg cgaacggcac cggatgggcg gaaggcgccg gtgtcctggt cgtggaacgg 5640
ctttccgatg cggagcgcaa cggtcacacc gttctcgcgg tcgtccgtgg ttctgcggtg 5700
aaccaggacg gcgcgtccaa cggcctctcc gcgccgaacg gcccgtcgca gcagcgcgtg 5760
atccggcagg ccctggcgaa cgcggggctc ggcgcggcgg atgtggatgt ggtggaggcg 5820
cacgggacgg ggacggttct gggggatccg atcgaggcgc aggcggttct ggcgacgtat 5880
gggcagggtc gtgaagttcc gttgttgttg ggttcgttga agtcgaacat cggtcatgcg 5940
caggcggcgg cgggtgttgc tggtgtcatc aagatggtga tggcgatgcg gcgtggggtg 6000
gtgccgcgga cgttgcatgt ggatgagccg tcgtcacacg tggactggac ggccggagct 6060
gttgaggtgg tcaccgaggc gaggccgtgg ccggagtccg gccgggtgcc gcgcgcgggt 6120
gtgtcgtcgt tcggggtcag tggcacgaac gcgcatgtgg tgctggaggg tgcgcctgag 6180
ccgtcttcgg gtgcggaggc ttcctcgggt ggggggttgg tgccgttgcc ggtgtcggcg 6240
cgtacggagt cgagtctggc ggtccaggtg gagcggctgg gtgcgtacgt gcggggtggg 6300
gcggacctgg gcgcggtggc ggatggtctg gtgcgtgggc gtgcggtgtt cgaccgtcgg 6360
gcggtgttgc tgggggagag cacggttgcc ggggtggctg tggagggggc gcggacggtg 6420
ttcgtgtttc cggggcaggg ctcgcagtgg gtggggatgg gccgggagtt gatgggcgtc 6480
tcggaggtgt tcgcggcgcg gatgcgggag tgtgcggcgg cgctggagcc gtacacgggg 6540
tgggatgtgc tggatgtgtt gggtgaggcg gtggtggctg atcgggtgga ggtgttgcag 6600
cccgcgtcgt gggcggtggc ggtgagtctg gccgcactgt ggcaggcgca tggtgtcgtc 6660
ccggatgcgg tggtggggca ttcgcagggg gagatcgccg cggcatgtgt ggcgggagcg 6720
ttgagtctgg aggacgccgc gcgggtcgtg gccttgcgca gccagaccat tgccgcgcgg 6780
ctggccgggc acggggcgat ggcgtcaatc gccttgcccg ccagtgccgt tgaggtgatg 6840
gagggggtgt ggatcgcggc gcgcaacggt ccggaatcca ccgtggtcgc gggcgatccg 6900
gcggcggtgg agcgggtgct ggcccggtat gaggctgcgg gtgtgcgggt gcgccggatc 6960
gcggtggatt acgcctcgca taccccgcac gtggaagcga tccaggacga actggccgac 7020
gtcttagggg ggatcaccag cagcgcacct gacatctcct ggtggtcgac ggtggacagc 7080
ggctgggtga ccgaagcggt cggcgacgac tactggtacc gcaacctgcg tcagccggtg 7140
gcgatggaca cggcggtcag tgagctggac ggttcgctgt tcatcgagtg cagcgcccac 7200
ccggtgctgc tgcccgccct ggaccaggag cgcacggtcg cttccctgcg taccgatgac 7260
ggcggctggg accggttcct gaccgccctc gcacaggcct ggacccaggg cgcggacgtc 7320
gactggacca ccctgatcga gcccgcccag caccgcctgt tggacctgcc cacctacccc 7380
ttcgaccaca agcggtactg gctgcagccc gccccggtcg gcggcgcggg gatcgggcat 7440
ccgttcctgt cgagtgcggc ggtgctgccg ggcagcgacg gcgtgctgct cacgggccgg 7500
atctctctgc gtacccatcc ctggctggcc gatcacacgg tgcaggacac ggtgttgctg 7560
ccgggcacgg cgttgctcga actcgtggtg cgggccggtg acgaggtcgg ctgcgacacc 7620
atcgacgagc tggtcatcga gacgccactc accctgcccg tgaccggtgc tgccgatctc 7680
accgtcaccg tcgatcagcc cgacaccacc ggacgccgcc cagtgagcgt ccacgcacgc 7740
cccgaaggaa ccgacacctg gacccgccac gccaccggca cactcaccac caacatcggc 7800
cctgatccca cccatcccga ttccagcacc gacacgttcc tccagtggcc cccgcccaac 7860
gcacaacctg tcgacgtcac caccttctac gacgagctcg ctgacgccgg ttacggctat 7920
ggaccggcgt tccagggact gcgcgccgcc cgacaagatg gcgacaccgt ctacgcggac 7980
gtcaccctct ccgacgagca agccgccgag gcgacccgct atgccctgca ccccgccctg 8040
ctcgacgcgg ccctgcaagc cgtcgccttc accgtgccgg acgacagtgc ccccggcctg 8100
ccgttcgcgt ggacgggggc ccggttcgtc agcgccggtc ccaccacgct ccgagtcgtg 8160
atcacccggg acggggacga actgagcctg cgcgccgccg actccaccgg ccaactggtc 8220
gccgagatcc ggacgatccg cacccgcccg ctctccccgc ccgcggacac cggcctgatg 8280
cgcctggcct ggaccgaggt cgccgtaccc gtggacgtcc ccacgggcga cgtggacgtc 8340
atcacgctgc acgccgctgc cgacgatgac ccgacggccg agacacgcgc gctgacggcc 8400
cacttgctgg cggccctgac cggaaccgac cagaccctgc tcgtgcacac caccgagggc 8460
ctcgccaccg ccgcggccgc cgggctcctg cgcgccgccc aggccgagca acccggccgg 8520
ttcgtccacg tcgagaccgc gcccggagtc acactcgaac ccgagcagca gcgcatcgct 8580
gtcgcactgg acgagccacg tcttcgcctg cgccgcggcc ggttcgaggc ggcccgcctc 8640
acccgtgtgc cggaaccgct catcgtgccg gagagcgata cgtggttgat ccgaccggcg 8700
cccacgggca ctctcgacgg cctcaccgcg gccgattcgg cggaaccctg gcgcccgttg 8760
gcgccgaccg aggtccggat cggcgtacgt gcggcgggtc tcaacttccg tgacgtgctg 8820
atcgcgctcg gcacctatcc cggccggggc gttctcggcg gcgaggctgc gggcgtcgtc 8880
ctggagaccg gcgcagacgt ttccggcctg acagcgggcg accgcgtctt cggcctcgtg 8940
gggaccggtt tcggccccac ggtcatcgcc gaccaccgca tgctgggccg gatgccggac 9000
gactggacgt tcccgcaggc ggcgtcggtg gtgacggtgt tcgcgaccgc ctggtacggc 9060
ctggtcgacc tggccaagct gcgccccggc gagcaggtcc tcatccacgc tgcggccacc 9120
ggagtcggcg cggccgccgt ccagatcgcc cgccacctgg gcgcggacgt gtacgccacc 9180
gccagcaccc ccaaacagca cctggtggac ctggcaccca cccacatcgc cgactcccgc 9240
agcaccgcgt tcgccgacac cttccccccg gtcgacgtcg tactcaactc cctcaccggc 9300
gaactcctcg acacctccac cgcactcctc gcacccggcg gccggttcat cgaaatgggc 9360
aagaccgaca tccgccacca cgcccagcag cccttcgacc tcatggacgc gggacccgac 9420
cgactccagc agatcatcac ccaactcctc gacctgttcg cgaacggcac actgcacccc 9480
ctaccggtga tggttcacga catacgtcag gcccgcgacg cgctggcgac catgagccga 9540
ggcgaacacg tcggcaagct ggtgctgacg gtcccgcggc cgctcgaccc cgagggcgcc 9600
gtcatcatca ccggcggctc cggcaccctc gccggaatcc tcgcccgcca cctcaaccac 9660
ccccacacct acctcctctc ccgcacaccc ccgcccgaca ccacccccgg cacccacctg 9720
ccctgcgacg tcagcgaccc cacccaactc gccaccgccc tcgcccagat acccgaaccc 9780
ctcaccggcg tcttccacac cgccgccgcc ctcgacgacg ccctcctcga caacctcaca 9840
ccccaacgca tcgacaccgt cctccaaccc aaagccgacg ccgcctggca cctccaccac 9900
cacacccaca cccacgccac cgacctcgcc gcattcgtcc tctactcgtc cgctgccggt 9960
gtgttgggca cgccaggtca gggcaactac gcggcggcga acgcgttcct cgacgcactc 10020
gccgaacacc gccgtacgca ggggctgcca ggcctttcga tcgcgtgggg gctgtgggac 10080
caggcgagcg gtctgaccgg cgagctgacc gacgccgacc ggcgccgcat gcgtcaaggc 10140
ggggcgaggg cactcaccgc cgagcagggc atgcgcatgt acgacgccgc cgttcatgcc 10200
ggaacgggca gtgtcgtcgc cgtggcgggt gaacttcctt cggacatacc gctgttgcgc 10260
ggtcgccgca aaccggtggc ccggcggggc gcccgcaacg aggtcgcgcg ccacaccgac 10320
ctgctcacgc tcgtacggca gaaggcggca gccctgctgg ggcacgcggg accggaggac 10380
gtcccggagg acgcggcgtt ccggcagctc ggcgtcgact cgctcatcgc ggtgcaactg 10440
cgcaatggcc tcaacgaagc gaccggtctg cggctctccg ccacgctcgt cttcgactat 10500
ccgacgccgc gcgcgctcgc aggccgcatc ggtgaactcc tgtccccgga cgatccggcg 10560
gccgcggtac tcgcgcaact cgaccgcctt gaggaactgg tcgcggacgt cgacccgggt 10620
gatcgcagga acgactcgat cgggccccgc atcggcgccc tgttcgagcg ctggcagcgg 10680
gtgggccgcc cggccgtacc ggcggacgtg ttgtccgagg acgcgaccgc ggacgagatc 10740
ttcgacctca tcgaccggga gctgcgcaca gccccgacca agaaagggag gtga 10794
<210> 77
<211> 7591
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 77
Leu Leu Arg Val Asn Ala Glu Arg His Gly Asp Arg Val Ala Tyr Thr
1 5 10 15
Asp Ser Arg Arg Ala Val Thr Tyr Glu Arg Leu Gln Leu Arg Thr Gly
20 25 30
Arg Ile Ala Gly His Leu Ala Ala Ser Gly Val Gly Arg Gly Asp Arg
35 40 45
Val Ala Leu Leu Leu Gly Asn Arg Ile Glu Thr Ile Glu Val Tyr Leu
50 55 60
Ala Ala Ala Arg Ala Ala Ala Val Ala Val Pro Leu Asn Pro Asp Ala
65 70 75 80
Ala Asp Ala Glu Leu Ala His Phe Leu Thr Asp Ser Gly Ala Thr Val
85 90 95
Leu Val Thr Asp Asp Leu His Leu Asp Gln Val Arg Arg Ile Gly Thr
100 105 110
Asp Ala Thr Val Val Leu Ala Gly Arg Gln Glu Pro Gly Cys Ile Ala
115 120 125
Tyr Glu Asp Leu Ala Gly Thr Glu Pro Pro Arg Pro Pro Arg Asp Asp
130 135 140
Leu Gly Leu Asp Glu Pro Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr
145 150 155 160
Gly Arg Pro Lys Gly Val Val Ser Ala Gln Arg Ser Gly Leu Trp Ser
165 170 175
Ala Met Tyr Cys Asp Val Pro Ser Trp Gln Leu Thr Glu Asp Asp Glu
180 185 190
Leu Leu Trp Pro Ala Pro Leu Phe His Ser Leu Gly His His Leu Cys
195 200 205
Leu Leu Ala Val Leu Thr Val Gly Ala Ser Ala Arg Ile Leu Gly Gly
210 215 220
Phe Val Ala Arg Asp Val Leu Asp Ala Leu Ala Glu His Pro Cys Thr
225 230 235 240
Val Leu Val Gly Val Pro Thr Met Tyr Arg Tyr Leu Leu Gly Ala Val
245 250 255
Ser Gly Glu Gln Glu Thr Arg Ala Leu Arg Val Ala Leu Val Ala Gly
260 265 270
Ser Thr Ala Pro Ala Ser Leu Thr Ala Gly Phe Glu Ala Ala Phe Gly
275 280 285
Ala Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu
290 295 300
Thr Ala Asn Thr Leu Thr Asp Ala Arg Val Pro Gly Ser Cys Gly Leu
305 310 315 320
Pro Val Pro Gly Leu Ser Leu Arg Phe Val Asp Pro Val Thr Gly Ala
325 330 335
Asp Val Ala Arg Gly Asp Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser
340 345 350
Leu Met Leu Gly Tyr His Ala Gln Thr Glu Ala Thr Ala Gln Val Leu
355 360 365
Val Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Gln Ala Glu Thr
370 375 380
Gly His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Gly
385 390 395 400
Gly Glu Asn Ile His Pro Arg Glu Ile Glu Ser Val Ala Gln Glu Val
405 410 415
Pro Gly Val Arg Asp Ala Ala Ala Ala Gly Arg Pro His Pro Val Leu
420 425 430
Gly Glu Ile Pro Val Leu Tyr Val Val Pro Glu Gly Pro Gly Val Pro
435 440 445
Val Glu Ala Ile Leu Ala Glu Cys Arg Arg Gln Leu Ala Tyr Phe Lys
450 455 460
Val Pro Asp Glu Ile Leu His Val Ala Thr Val Pro Arg Thr Ala Ser
465 470 475 480
Gly Lys Val Arg Arg Gly Glu Leu Ala Gly Leu Pro Ala Arg Leu Val
485 490 495
Gly Thr Gly Ser Gly Glu Ala Ala Leu Cys Glu Leu Val Trp Glu Arg
500 505 510
Arg Glu Leu Pro Asp Thr Val Ser Gln Ala Arg Thr Val Val Thr Arg
515 520 525
Arg Ala Val Gly Ile Gly Pro Ala Glu Val Pro Asp Thr Asp Gln Ala
530 535 540
Leu Leu Trp Asp Glu Ala Leu Val Arg Gln Ala Ala Glu Pro Gly Ser
545 550 555 560
Phe Val Leu Val Asp Thr Asp Ala Asp Asn Gly Asp Glu Ala Asp Glu
565 570 575
Leu Val Ala Ala Ala Ala Ala Leu Gly Glu Pro Gln Val Ala Leu Arg
580 585 590
Ser Gly Val Ala Tyr Val Pro Arg Leu Val Arg Ala Asn Thr Thr Pro
595 600 605
Leu Pro Thr Thr Pro Trp Ala Leu Arg Pro Pro Ala Ser Gly Thr Leu
610 615 620
Arg Asp Leu Ala Val Val Pro Ser Asp Ala Pro Pro Arg Pro Leu Ala
625 630 635 640
Ala Gly Glu Val Arg Ile Asp Val Arg Ala Ala Gly Leu Asn Phe Arg
645 650 655
Asp Val Leu Ile Ala Leu Gly Thr Tyr Pro Gly Asp Gly Ala Met Gly
660 665 670
Gly Glu Ala Ala Gly Ile Val Thr Glu Val Gly Pro Gly Val Asp Asp
675 680 685
Leu Val Pro Gly Ala His Val Phe Gly Leu Val Gln Asp Ala Phe Arg
690 695 700
Arg Ser Val Val Ala Asp Arg Arg Leu Val Ala Arg Ile Pro Arg Asp
705 710 715 720
Trp Ser Phe Pro Val Ala Ala Ser Val Pro Ile Val Phe Ala Thr Ala
725 730 735
Trp Tyr Gly Leu Val Asp Ala Gly Glu Val Arg Pro Gly Gln Lys Val
740 745 750
Leu Ile His Ala Ala Thr Gly Gly Val Gly Ser Ala Ala Arg Gln Ile
755 760 765
Ala Arg His Leu Gly Ala Glu Val Tyr Ala Thr Ala Ser Pro Ala Lys
770 775 780
Gln His Leu Leu Leu Thr Asp Gly Phe Asp Ala Asp His Val Ala Asn
785 790 795 800
Ser Arg Thr Thr Ala Phe Ala Asp Ala Phe Pro Pro Val Asp Val Val
805 810 815
Leu Asn Ser Leu Thr Gly Glu Phe Leu Asp Ala Ser Val Asp Leu Leu
820 825 830
Ala Pro Gly Gly Arg Phe Val Glu Met Gly Lys Thr Asp Ile Arg His
835 840 845
Asp Val Gln Gln Pro Phe Asp Leu Ser Asp Val Asp Pro Ala Arg Leu
850 855 860
Arg Glu Ile Leu Glu Leu Leu Leu Glu Leu Phe Asp Arg Gly Glu Leu
865 870 875 880
Arg Pro Leu Pro Val Arg Pro Trp Asp Ile Arg Arg Ala Arg Asp Ala
885 890 895
Phe Gly Trp Met Ser Gln Ala Arg Asn Thr Gly Lys Thr Val Leu Thr
900 905 910
Val Pro His Pro Leu Gly Pro Asp Ser Pro Val Leu Val Thr Gly Glu
915 920 925
Gly Ala Asp Ala Ala Ala Gly Leu Leu Arg Asp Glu Thr Gly Arg Thr
930 935 940
His Val Ser Ser Ser Ala Ala Glu Ala Glu Gly Ala Glu Glu Ala Glu
945 950 955 960
Gln Gly Val Asn Ala Ser Thr Leu Ala His Val Leu Leu Gly Asp Pro
965 970 975
Ala Gly Ala Asp Ala Tyr Ala Arg Ser Arg Ala Pro Glu Gly Leu Pro
980 985 990
Ile Val Thr Val His Gly Leu Pro Gly Ile Glu Gln Ala Pro Leu Thr
995 1000 1005
Gly Glu Leu Leu Glu Glu Ala Ile Glu Gly Gly Gly Ser Tyr Val
1010 1015 1020
Val Thr Arg Val Gly Ser Ala Gly Ala Arg Ala Glu Ala Met Ala
1025 1030 1035
Gly Ala Thr Pro Pro Ile Leu Ser Gly Leu Ala Gly Val Ala Gly
1040 1045 1050
Pro Ala Gly Pro Thr Asp Gln Ala Glu Pro Gly Ala Ala Gly Pro
1055 1060 1065
Glu Trp Ala Ser Leu Leu Ala Ala Ala Asp Ala Asp Arg Glu Lys
1070 1075 1080
Val Leu Leu Asp Leu Val Arg Asp Ser Val Ala Thr Val Leu Gly
1085 1090 1095
Leu Pro Gly Ala Glu Arg Cys Ala Pro Asp Arg Thr Phe Arg Glu
1100 1105 1110
Asn Gly Leu Asp Ser Leu Thr Thr Val Glu Phe Ala Asn Thr Val
1115 1120 1125
Thr Ala Arg Thr Gly Leu Arg Val Pro Ala Ser Thr Ala Phe Asp
1130 1135 1140
His Pro Thr Pro Arg Ser Phe Ala Ala His Leu Ala Gly Ser Val
1145 1150 1155
Ala Ala Pro Ala Ala Lys Ala Ala Leu Gly Ser Gly Glu Pro Val
1160 1165 1170
Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Thr Ser
1175 1180 1185
Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala Ile
1190 1195 1200
Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Phe
1205 1210 1215
Asp Pro Asp Pro Asp Ala Val Gly Arg Ser Thr Thr Arg His Gly
1220 1225 1230
Gly Phe Leu Thr Glu Ala Thr Gly Phe Asp Ala Ala Phe Phe Gly
1235 1240 1245
Ile Ser Pro Asn Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu
1250 1255 1260
Val Leu Glu Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Val
1265 1270 1275
Pro Asp Thr Leu Arg Glu Ser Asp Thr Gly Val Phe Met Gly Ala
1280 1285 1290
Phe His Gln Gly Tyr Gly Ala Gly Arg Asp Leu Gly Gly Leu Gly
1295 1300 1305
Val Thr Ala Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr
1310 1315 1320
Phe Tyr Gly Leu Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys
1325 1330 1335
Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg
1340 1345 1350
Ser Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val Met
1355 1360 1365
Ala Thr Pro Gly Ser Phe Val Glu Phe Ser Arg Gln Arg Gly Leu
1370 1375 1380
Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly
1385 1390 1395
Thr Gly Phe Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu
1400 1405 1410
Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Val Val Arg
1415 1420 1425
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
1430 1435 1440
Pro Asn Gly Val Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
1445 1450 1455
Asn Ala Gly Leu Asn Gly Thr Asp Val Asp Ala Val Glu Ala His
1460 1465 1470
Gly Thr Gly Thr Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
1475 1480 1485
Leu Ala Thr Tyr Gly Gln Glu Arg Glu Val Pro Leu Leu Leu Gly
1490 1495 1500
Ser Val Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val
1505 1510 1515
Ala Gly Val Ile Lys Met Val Met Ala Met Arg Arg Gly Val Val
1520 1525 1530
Pro Arg Thr Leu His Val Asp Glu Ser Ser Ser His Val Asp Trp
1535 1540 1545
Ser Ala Gly Ala Val Glu Val Val Thr Glu Ala Arg Pro Trp Pro
1550 1555 1560
Glu Ser Gly Gly Ala Arg Arg Ala Gly Val Ser Ser Phe Gly Val
1565 1570 1575
Ser Gly Thr Asn Ala His Val Ile Leu Glu Gly Val Ala Glu Ser
1580 1585 1590
Ser Val Arg Ser Gly Gly Ser Ser Ala Gly Leu Val Pro Leu Pro
1595 1600 1605
Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Leu Gln Val Glu Arg
1610 1615 1620
Leu Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu Gly Ala Val Ala
1625 1630 1635
Asp Gly Leu Val Arg Gly Arg Ala Val Phe Gly Arg Arg Ala Val
1640 1645 1650
Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala Val Glu Gly Ala
1655 1660 1665
Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly
1670 1675 1680
Met Gly Arg Glu Leu Met Gly Val Ser Glu Val Phe Ala Ala Arg
1685 1690 1695
Met Arg Glu Cys Ala Ala Ala Leu Glu Pro His Thr Gly Trp Asp
1700 1705 1710
Val Leu Asp Val Leu Gly Glu Ala Val Val Ala Asp Arg Val Glu
1715 1720 1725
Val Leu Gln Pro Ala Ser Trp Ala Val Ala Val Ser Leu Ala Ala
1730 1735 1740
Leu Trp Gln Ala His Gly Val Val Pro Asp Ala Val Val Gly His
1745 1750 1755
Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser
1760 1765 1770
Leu Glu Asp Ala Ala Arg Val Val Ala Leu Arg Ser Gln Thr Ile
1775 1780 1785
Ala Ala Arg Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu
1790 1795 1800
Pro Ala Ser Ala Val Glu Val Met Glu Gly Val Trp Ile Ala Ala
1805 1810 1815
Arg Asn Gly Pro Glu Ser Thr Val Val Ala Gly Asp Pro Ala Ala
1820 1825 1830
Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala Gly Val Arg Val
1835 1840 1845
Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu
1850 1855 1860
Ala Ile Gln Asp Glu Leu Ala Asp Val Leu Gly Gly Ile Thr Ser
1865 1870 1875
Ser Ala Pro Ser Val Pro Trp Trp Ser Thr Val Asp Ser Gly Trp
1880 1885 1890
Val Thr Glu Pro Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu Arg
1895 1900 1905
Gln Pro Val Ala Met Asp Thr Ala Thr Gly Glu Leu Asp Gly Ser
1910 1915 1920
Leu Phe Ile Glu Cys Ser Ala His Pro Val Leu Leu Pro Ala Leu
1925 1930 1935
Asp Gln Glu Arg Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Gly
1940 1945 1950
Trp Glu Arg Phe Leu Thr Ala Leu Ala Glu Ala Trp Thr Gln Gly
1955 1960 1965
Ala Asp Val Asp Trp Thr Thr Leu Ile Glu Pro Ala Gln His Arg
1970 1975 1980
Val Leu Asp Leu Pro Thr Tyr Pro Phe Asp His Lys Arg Tyr Trp
1985 1990 1995
Leu Gln Pro Ala Pro Ala Gly Gly Ala Gly Ile Gly His Pro Phe
2000 2005 2010
Leu Ser Ser Ala Ala Val Leu Pro Gly Ser Asp Gly Val Leu Leu
2015 2020 2025
Thr Gly Lys Leu Ser Leu Ala Thr His Pro Trp Leu Ala Asp His
2030 2035 2040
Ala Val Gln Asp Thr Val Leu Leu Pro Gly Thr Ala Phe Leu Glu
2045 2050 2055
Leu Val Val Arg Ala Gly Asp Glu Val Gly Cys Asp Thr Ile Asp
2060 2065 2070
Glu Leu Val Ile Glu Thr Pro Leu Val Leu Pro Val Thr Gly Ala
2075 2080 2085
Val Asp Leu Thr Val Thr Val Asp Gln Pro Asp Thr Thr Gly His
2090 2095 2100
Arg Pro Val Ser Val His Ala Arg Pro Glu Gly Thr Asp Thr Trp
2105 2110 2115
Thr Arg His Val Thr Gly Thr Leu Thr Thr Ser Ala Thr Asp Thr
2120 2125 2130
Thr Pro Ala Pro Asn Ser Phe Pro Gln Trp Pro Pro Thr Gly Ala
2135 2140 2145
Gln Pro Ala Ser Leu Asp Gln Phe Tyr Glu Gln Leu Ala Ala Ala
2150 2155 2160
Gly Tyr Thr Tyr Gly Pro Ala Phe Gln Gly Leu Arg Ala Ala Trp
2165 2170 2175
Arg Ala Gly Asp Thr Ile Tyr Ala Glu Val Ala Leu Pro Glu Asp
2180 2185 2190
Arg Ala Ala Asp Val Asp Arg Phe Gly Val His Pro Ala Leu Leu
2195 2200 2205
Asp Ala Ala Leu His Ala Gly Arg Leu Asp Ala Gly Asp Glu Leu
2210 2215 2220
Glu Leu Pro Phe Ser Trp Thr Gly Val Arg Leu His Ala Thr Gly
2225 2230 2235
Ala Thr Ala Val Arg Val Ala Leu Thr Arg Gly Pro Ala Gly Val
2240 2245 2250
Ala Val Gln Val Ala Asp Pro Asp Gly Arg Pro Val Val Ser Val
2255 2260 2265
Asp Ala Leu Val Leu Arg Pro Arg Ser Ala Thr Pro Ser Gly Pro
2270 2275 2280
Asn Leu Leu Gly Leu Glu Trp Leu Pro Val Ala Glu Ala His Tyr
2285 2290 2295
Asp Gly Ala Asp Ser Leu Pro Glu Gly Tyr Thr Leu Ile Thr Ala
2300 2305 2310
Thr His Pro Asp Asp Pro Glu Asp Asp Pro Thr Asn Pro His Ser
2315 2320 2325
Thr Pro Thr Arg Thr His Thr Gln Thr Thr Arg Val Leu Ala Ala
2330 2335 2340
Leu Gln His His Leu Thr Thr Thr Asn His Thr Leu Ile Ile His
2345 2350 2355
Thr Thr Thr Asp Pro Pro Gly Ala Ala Val Thr Gly Leu Thr Arg
2360 2365 2370
Thr Ala Gln Asn Glu His Pro Gly Arg Ile His Leu Ile Glu Thr
2375 2380 2385
His His Pro His Thr Pro Leu Pro Leu Thr Gln Leu Thr Thr Leu
2390 2395 2400
Asn Gln Pro His Leu Arg Leu Thr Asn Asn Thr Leu His Thr Pro
2405 2410 2415
His Leu Thr Pro Leu Thr Pro Arg Thr Asn Pro Asn Pro Asn Pro
2420 2425 2430
Asn Pro His His Pro Thr Thr Pro Thr Pro Pro Leu Asn Pro His
2435 2440 2445
His Ala Ile Leu Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile
2450 2455 2460
Leu Ala Arg His Leu Asn His Pro His Thr Tyr Leu Leu Ser Arg
2465 2470 2475
Thr Pro Pro Pro Pro Thr Thr Pro Gly Thr His Ile Pro Cys Asp
2480 2485 2490
Leu Thr Asp Pro Thr Gln Ile Thr His Ala Leu Asn Gln Ile Pro
2495 2500 2505
Gln Pro Leu Thr Gly Ile Phe His Thr Ala Ala Thr Leu Asp Asp
2510 2515 2520
Thr Pro Leu His Thr Leu Thr Pro Gln Arg Leu Thr Thr Val Leu
2525 2530 2535
Gln Pro Lys Ala Asp Ala Ala Trp His Leu His His His Thr Gln
2540 2545 2550
Asn Gln Pro Leu Thr His Phe Val Leu Tyr Ser Ser Ala Ala Ala
2555 2560 2565
Thr Leu Gly Ser Pro Gly Gln Ala Asn Tyr Ala Ala Ala Asn Ala
2570 2575 2580
Phe Leu Asp Ala Leu Ala Thr His Arg His Thr His Asn Gln Pro
2585 2590 2595
Ala Thr Thr Ile Ala Trp Gly Met Trp His Thr Thr Thr Thr Leu
2600 2605 2610
Thr Gly Gln Leu Gly Asp Thr Glu Arg Gln Arg Val Arg Asp Gly
2615 2620 2625
Phe Arg Pro Leu Thr Glu Ala Glu Gly Asn His Phe Leu Asp Ala
2630 2635 2640
Ser Leu Ala Thr Asp Val Pro Phe Val Val Ala Ala Ile Pro Ala
2645 2650 2655
Glu Pro Ala Arg Arg Arg Val Glu Arg Arg Thr Val Arg Thr Gly
2660 2665 2670
Glu Asp Ser Gly Arg Asp Leu Leu Ala Val Val Cys Gly Ala Thr
2675 2680 2685
Ala Ala Val Leu Gly His Ala Asp Ala Ser Glu Ile Gly Pro Ala
2690 2695 2700
Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Ser Gly Ile Arg
2705 2710 2715
Leu Arg Asn Ser Leu Ala Glu Thr Thr Gly Val Arg Leu Ser Ala
2720 2725 2730
Thr Ala Val Phe Asp His Pro Thr Pro Asp Ala Leu Ala Ala Arg
2735 2740 2745
Leu Ala Glu Glu Leu Arg Gly Asp Glu Glu Ser Pro Gly Ala Ala
2750 2755 2760
Ala Ala Ala Ala Ala Gln Arg Thr Val Pro Thr Leu Ala Val Ala
2765 2770 2775
Gly Asp Glu Pro Leu Ala Ile Val Ala Met Ala Cys Arg Met Pro
2780 2785 2790
Gly Gly Val Asp Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser
2795 2800 2805
Gly Gly Asp Ala Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp
2810 2815 2820
Leu Ala Ala Leu Tyr Asp Pro Asp Pro Asp Ala Ile Gly Lys Val
2825 2830 2835
Ser Val Arg His Gly Gly Phe Leu Ala Gly Ala Ala Asp Phe Asp
2840 2845 2850
Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp
2855 2860 2865
Pro Gln Gln Arg Leu Ile Leu Glu Val Ser Trp Glu Ala Phe Glu
2870 2875 2880
Arg Ala Gly Ile Leu Pro Ala Ser Val Arg Gly Ser Asp Ala Gly
2885 2890 2895
Val Phe Met Gly Ala Phe Thr Gln Gly Tyr Gly Ala Gly Val Asp
2900 2905 2910
Leu Gly Gly Phe Gly Ala Thr Gly Thr Pro Thr Ser Val Leu Ser
2915 2920 2925
Gly Arg Leu Ser Tyr Tyr Phe Gly Leu Glu Gly Pro Ser Val Thr
2930 2935 2940
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
2945 2950 2955
Ala Arg Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val Gly
2960 2965 2970
Gly Val Thr Val Met Ala Thr Thr Thr Gly Phe Val Glu Phe Ser
2975 2980 2985
Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Ala
2990 2995 3000
Asp Thr Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Val Leu
3005 3010 3015
Ile Val Glu Arg Leu Ser Asp Ala Thr Arg Leu Gly His Pro Val
3020 3025 3030
Leu Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser
3035 3040 3045
Asn Gly Leu Ser Ala Pro Asn Gly Pro Ala Gln Arg Arg Val Ile
3050 3055 3060
Glu Arg Ala Leu Asp Asp Ala Gly Leu Val Pro Gly Asp Ile Asp
3065 3070 3075
Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile
3080 3085 3090
Glu Ala Gln Ala Leu Glu Ala Ala Tyr Gly Leu Asp Arg Val His
3095 3100 3105
Pro Leu Leu Ile Gly Ser Leu Lys Ser Asn Leu Gly His Thr Gln
3110 3115 3120
Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Met
3125 3130 3135
Arg His Gly Val Leu Pro Arg Thr Leu His Val Asp Glu Pro Ser
3140 3145 3150
Arg His Val Asp Trp Gly Gly Gly Val Arg Leu Leu Arg Arg Asn
3155 3160 3165
Glu Pro Trp Pro Val Thr Gly Arg Val Arg Arg Ala Gly Val Ser
3170 3175 3180
Ser Phe Gly Ile Ser Gly Ala Asn Ala His Val Val Ile Glu Ala
3185 3190 3195
Gly Pro Pro Ala Ala Pro Ala Thr Leu Pro Ala Thr Glu Pro Val
3200 3205 3210
Pro Glu Gly Val Val Trp Pro Val Ser Ala Arg Thr Pro Asp Gly
3215 3220 3225
Val Arg Asp Val Ala Gly Arg Leu Val Ala Leu Thr Ala Pro Ala
3230 3235 3240
Ala Ala Ile Gly His Ser Leu Ala Thr Thr Arg Thr Ala Met Arg
3245 3250 3255
His Arg Ala Val Val Pro Ala Arg Asp Ala Glu Ala Phe Ala Arg
3260 3265 3270
Gly Glu Glu Val Pro Gly Val Val Arg Gly Thr Ala Asp Val Thr
3275 3280 3285
Asp Ala Arg Ala Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp
3290 3295 3300
Asp Gly Met Gly Ala Glu Leu Leu Ala Thr Glu Pro Val Phe Ala
3305 3310 3315
Arg Arg Leu Gly Glu Cys Ala Glu Ala Leu Ala Pro Tyr Thr Gly
3320 3325 3330
Trp Asp Leu Leu Asp Val Ile Ala Arg Arg Pro Gly Ala Pro Ala
3335 3340 3345
Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Phe Ala Met Met
3350 3355 3360
Val Ala Leu Ala Glu Leu Trp Arg Ser Arg Gly Val Ala Pro Ala
3365 3370 3375
Ala Val Val Gly His Ser Gln Gly Glu Val Ala Ala Ala Cys Val
3380 3385 3390
Ala Gly Val Leu Thr Leu Asp Asp Ala Ala Lys Val Val Ala Leu
3395 3400 3405
Arg Ser Arg Leu Val Ala Thr Glu Leu Ala Gly His Gly Gly Met
3410 3415 3420
Val Ser Val Pro Pro Ala Asp Phe Asp Ala Ala Ala Trp Ala Gly
3425 3430 3435
Arg Leu Glu Val Ala Ala Val Asn Gly Pro Ala Ser Ile Val Val
3440 3445 3450
Ala Gly Ala Ala Asp Ala Val Glu Glu Leu Leu Ala Ala Thr Pro
3455 3460 3465
His Ala Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Ala His
3470 3475 3480
Val Glu Thr Ile Arg Asp Ala Leu Leu Asp Ala Leu Ala Asp Leu
3485 3490 3495
Thr Pro Gly Ala Pro Glu Val Pro Phe Phe Ser Thr Val Asp Glu
3500 3505 3510
Ala Trp Leu Asp Arg Pro Ala Asp Ala Ala Tyr Trp Tyr Asp Asn
3515 3520 3525
Val Arg Arg Pro Val Arg Phe Gly Ala Ala Thr Ala Arg Leu Ala
3530 3535 3540
Glu Leu Gly Tyr Arg Val Phe Val Glu Ala Ser Pro His Pro Val
3545 3550 3555
Leu Thr Thr Ala Leu Ala Asp Thr Leu Ala Gly His Pro Asn Thr
3560 3565 3570
Ala Val Thr Gly Thr Leu Arg Arg Gly Asp Gly Gly Ala Arg Arg
3575 3580 3585
Phe Thr Ser Ser Leu Ala Glu Leu Trp Val Arg Gly Val Pro Val
3590 3595 3600
Ser Trp Pro Ser Gly Glu Ser Arg Arg Val Pro Leu Pro Thr Tyr
3605 3610 3615
Pro Phe Arg Arg Asp Arg Tyr Trp Ile Asp Ala Glu Pro Ala Gly
3620 3625 3630
Thr Ser Gly His Pro Leu Leu Gly Ser Leu Val Glu Arg Ala Asp
3635 3640 3645
Gly Glu Gly Ala Phe Ala Thr Ala Leu Phe Ser Val Arg Arg Gln
3650 3655 3660
Pro Trp Leu Ala Asp His Glu Val Asp Gly Arg Ile Ile Val Pro
3665 3670 3675
Gly Ser Ala Leu Val Glu Leu Leu Ala Glu Ala Gly Ala Arg Leu
3680 3685 3690
Gly Thr Pro Thr Ile Ala Glu Leu Thr Ile Val Ala Pro Val Val
3695 3700 3705
Val Asp Glu Glu Arg Asp Thr Glu Ile Gln Leu Thr Val Gly Thr
3710 3715 3720
Glu Val Ser Gly Arg Arg Pro Val Arg Leu His Cys Arg Thr Gly
3725 3730 3735
Ala Gly Pro Trp Thr Val Gly Ala Thr Gly Ala Leu Ser Ala Asp
3740 3745 3750
Thr Ser Asp Pro Glu Pro Leu Glu Trp Pro Pro Ala Asp Ala Glu
3755 3760 3765
Pro Val Asp Leu Thr Gly Phe Tyr Asp Thr Leu Pro Ile Ser Tyr
3770 3775 3780
Gly Pro Ala Phe Arg Ala Met Thr Ala Met Trp Ala Gly Gln Gly
3785 3790 3795
Arg Ala Tyr Ala Ser Val Arg Leu Gly Glu Gln Leu Thr Asp Ala
3800 3805 3810
Arg Tyr Gly Leu His Pro Val Leu Leu Asp Ala Ala Val His Ala
3815 3820 3825
Leu Gly Thr Leu Phe Ala Asp Pro Glu Arg Pro Arg Leu Ala Phe
3830 3835 3840
Ser Trp Ser Gly Val Arg Ile His Ala Arg Ala Ala Thr Thr Leu
3845 3850 3855
Arg Val Leu Leu Glu Arg Ala Asp Gly Asp Thr Ile Arg Ile Leu
3860 3865 3870
Ala Thr Asp Glu His Gly Ala Pro Val Leu Asp Val Asp Gly Leu
3875 3880 3885
Thr Val Arg Ala Ala Glu Pro Gly Thr Glu Ala Leu Phe Glu Val
3890 3895 3900
Ala Trp Val Pro Val Pro Ala Ser Pro Val Pro Gly Trp Thr Tyr
3905 3910 3915
Leu Ala Asp Val Pro Gly Gly Asp Val Ser Glu Gly Asp Leu Ile
3920 3925 3930
Glu Gly Asp Val Val Glu Gly Gly Val Gly Glu Ser Asp Pro Pro
3935 3940 3945
Pro Val Val Val Leu Pro Val Glu Pro Gly Asp Pro Gly Thr Ser
3950 3955 3960
Pro Gly Val Arg Ala Arg Glu Leu Gly Arg Asp Leu Leu Ala Thr
3965 3970 3975
Val Arg Thr Trp Leu Ala Glu Pro Arg Trp Ala Gln Ser Arg Leu
3980 3985 3990
Val Val Val Thr Arg Thr Gly Asp Pro Ala Gln Glu Ala Leu Gly
3995 4000 4005
Gly Leu Val Arg Thr Ala Gly Thr Glu His Pro Gly Arg Val Gly
4010 4015 4020
Leu Ile Glu Ala Asp Glu Ile Thr Pro Ala Thr Val Glu Ala Gly
4025 4030 4035
Leu Ala Val Gly Asp Glu Ser His Val Arg Val Thr Asp Gly Thr
4040 4045 4050
Val Arg Ala Ala Arg Leu Arg Arg Val Thr Ala Ser Thr Gly Ala
4055 4060 4065
Ser Pro Leu Ser Gly Gly Thr Val Leu Val Thr Gly Gly Thr Gly
4070 4075 4080
Gly Leu Gly Arg Arg Leu Val Asp His Leu Leu Thr Ala His Glu
4085 4090 4095
Ala Ala Glu Val Val Val Ala Ser Arg Gly Gly Arg Pro Asp Gly
4100 4105 4110
Ala Pro Glu Asp Asp Arg Val Arg Tyr Val Ala Ala Asp Val Thr
4115 4120 4125
Asp Arg Asp Glu Leu Ala Ala Leu Val Glu Gly Val Ala Glu Arg
4130 4135 4140
Leu Cys Ala Val Val His Met Ala Gly Ile Val Asp Asp Ala Val
4145 4150 4155
Val Ala Thr Met Arg Pro Gln Gln Trp Asp Ala Val Leu Arg Val
4160 4165 4170
Lys Ala Asp Val Ala Trp Gln Leu His Glu Leu Thr Arg Gly Leu
4175 4180 4185
Glu Leu Ala Ala Phe Val Leu Tyr Ser Ser Ile Ser Ala Thr Phe
4190 4195 4200
Gly Gly Ala Gly Gln Ala Asn Tyr Ala Thr Gly Asn Ala Phe Leu
4205 4210 4215
Asp Ala Leu Ala His His Arg Arg Asp Gln Gly Leu Pro Ala Val
4220 4225 4230
Ser Leu Ala Trp Gly Leu Trp Asp Glu Ala Asp Gly Met Gly Gly
4235 4240 4245
Arg Leu Thr Ala Thr Asp Leu Thr Arg Ile Ala Arg Gly Gly Met
4250 4255 4260
Ile Pro Met Thr Ala Glu Gln Gly Leu Ala Leu Phe Asp Ala Ala
4265 4270 4275
Leu His Ser Asp Arg Ala Ala Leu Val Pro Val Arg Leu Asp Leu
4280 4285 4290
Ala Ala Val Ala Ala Ser Asp Gln Val Pro Pro Ile Leu Arg Asp
4295 4300 4305
Leu Val Pro Ala Ala Arg Arg Ala Ala Ala Pro Thr Ala Ala Arg
4310 4315 4320
Asp Met Leu Glu Leu Val Arg Thr Ser Ala Ala Leu Val Leu Gly
4325 4330 4335
His Arg Asp Ala His Ala Ile Glu Pro Thr Arg Ala Phe Lys Glu
4340 4345 4350
Val Gly Phe Asp Ser Leu Thr Gly Val Glu Leu Arg Asn Arg Leu
4355 4360 4365
Ala Asp Ala Thr Gly Leu Thr Leu Pro Ala Thr Leu Val Phe Asp
4370 4375 4380
His Pro Thr Ala Gln Ala Leu Ala Ala His Leu Asp Glu Leu Ala
4385 4390 4395
Gly Ala Arg Thr Ala Thr Arg Arg Arg Ala Pro Ala Pro Ala Arg
4400 4405 4410
Arg His Asp Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu
4415 4420 4425
Pro Gly Gly Val Ala Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu
4430 4435 4440
Ser Gly Gly Asp Gly Ile Thr Thr Phe Pro Gly Asp Arg Gly Trp
4445 4450 4455
Asp Val Glu Ala Leu Tyr Asp Pro Asp Pro Glu His Pro Gly Thr
4460 4465 4470
Ser Thr Val Arg His Gly Gly Phe Leu Ser Gly Ala Gly Asp Phe
4475 4480 4485
Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala Met
4490 4495 4500
Asp Pro Gln Gln Arg Val Val Met Glu Thr Ser Trp Glu Ala Leu
4505 4510 4515
Glu Tyr Ala Gly Ile Asp Pro His Thr Leu Arg Gly Ser Asp Thr
4520 4525 4530
Gly Val Phe Met Gly Gly Tyr Phe Tyr Gly Tyr Gly Ser Gly Ala
4535 4540 4545
Asp Arg Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr Ser Val Leu
4550 4555 4560
Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ala Val
4565 4570 4575
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
4580 4585 4590
Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val
4595 4600 4605
Gly Gly Val Thr Val Met Ala Ser Pro Ser Gly Phe Val Asp Phe
4610 4615 4620
Ser Gln Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe
4625 4630 4635
Ala Glu Ala Ala Asp Gly Thr Gly Phe Ala Glu Gly Ser Gly Val
4640 4645 4650
Leu Val Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg
4655 4660 4665
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala
4670 4675 4680
Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Glu Arg Val
4685 4690 4695
Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Gln Pro Ser Asp Val
4700 4705 4710
Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro
4715 4720 4725
Ile Glu Ala Thr Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Ala
4730 4735 4740
Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr
4745 4750 4755
Gln Ala Ala Ala Gly Val Ala Gly Ile Ile Lys Met Val Leu Ala
4760 4765 4770
Met His His Asp Thr Leu Pro Ser Thr Leu His Val Asp Thr Pro
4775 4780 4785
Ser Ser His Val Asp Trp Thr Ala Gly Thr Val Glu Leu Leu Thr
4790 4795 4800
Asp Ala Arg Pro Trp Pro Glu Thr Ser Arg Pro His Arg Ala Ala
4805 4810 4815
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
4820 4825 4830
Glu Ser His Pro Arg Pro Thr Pro Ala Pro Asp Thr Gly Ser Ser
4835 4840 4845
Thr His Pro Val Pro Leu Leu Ile Ser Ala Arg Thr Pro Arg Ala
4850 4855 4860
Leu Ser Glu His Thr Thr Arg Val Ser Ala Phe Leu Asp Ala Gly
4865 4870 4875
Gly Gly Asp Glu Arg Ala Val Ala Ser Ala Leu Leu Thr Arg Thr
4880 4885 4890
Ala Phe Thr His Arg Ala Ala Leu Ile Gly Thr Asp Leu Ile Thr
4895 4900 4905
Gly Thr Ala Val Pro Asp Arg Arg Leu Val Trp Leu Phe Ser Gly
4910 4915 4920
Gln Gly Ser Gln Arg Pro Gly Met Gly Asp Glu Leu Ala Ala Ala
4925 4930 4935
Tyr Asp Val Phe Ala Arg Thr Arg Arg Asp Val Leu Asp Ala Leu
4940 4945 4950
Gln Val Pro Ala Gly Leu Asp Ile His Asp Thr Gly Tyr Ala Gln
4955 4960 4965
Pro Ala Val Phe Ala Leu Gln Val Ala Leu Ser Ala Gln Leu Asp
4970 4975 4980
Ala Trp Gly Val Arg Pro Asp Ala Leu Val Gly His Ser Ile Gly
4985 4990 4995
Glu Leu Ala Ala Ala Tyr Val Ala Gly Val Trp Ser Leu Asp Asp
5000 5005 5010
Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu
5015 5020 5025
Pro Pro Gly Gly Ala Met Ala Ala Val Ile Ala Ser Glu Arg Asp
5030 5035 5040
Ala Leu Pro Leu Leu Arg Glu Gly Val Glu Ile Ala Ala Val Asn
5045 5050 5055
Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu
5060 5065 5070
Asp Val Ala Ala Arg Leu Gly Arg Phe Thr Arg Leu Arg Thr Ser
5075 5080 5085
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe
5090 5095 5100
Arg Asp Val Ala Gln Arg Leu Thr Tyr His Glu Pro Lys Leu Pro
5105 5110 5115
Met Ala Ala Gly Ala Asp Cys Ala Thr Pro Glu Tyr Trp Val Arg
5120 5125 5130
Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln Val Ala Ala Tyr
5135 5140 5145
Asp Gly Ala Ala Leu Leu Glu Ile Gly Pro Asp Arg Asn Leu Ala
5150 5155 5160
Arg Leu Val Asp Gly Ile Pro Val Leu His Gly Asp Asp Glu Ala
5165 5170 5175
Arg Ser Ala Met Thr Ala Leu Ala Arg Leu His Thr Gly Gly Val
5180 5185 5190
Ala Val Asp Trp Pro Glu Val Ile Gly Ala Ala Pro Thr His Leu
5195 5200 5205
Pro Asn Leu Pro Thr Tyr Pro Phe Glu Arg Thr Arg Tyr Trp Leu
5210 5215 5220
Gly Ser Arg Ala Ala Gly Asp Ala Ala Gln Ala Gly Gln Leu Pro
5225 5230 5235
Val Ala His Pro Val Leu Thr Ala Ala Val Met Val Pro Gly Thr
5240 5245 5250
Gly Asp Leu Val Leu Thr Gly Arg Val Glu Ala Thr Asp Pro Leu
5255 5260 5265
Ala His Ser Val His Gly Ile Pro Val Leu Ser Ala Ala Val Leu
5270 5275 5280
Leu Asp Leu Ala Ile Thr Ala Gly Gly Glu Ala Gly Cys Asp Ala
5285 5290 5295
Val Glu Thr Phe Thr Val Asp Thr Pro Val Thr Leu Pro Gln Ser
5300 5305 5310
Gly Gly Leu Ala Leu Ser Val Thr Val Ala Ala Pro Arg Glu Asp
5315 5320 5325
Gly Arg Arg Ala Val Thr Val His Ala Arg His Gly Thr Gly Glu
5330 5335 5340
Trp Thr Glu His Ala Thr Gly Ile Leu Ala Arg Ala Ala Arg Ala
5345 5350 5355
Ala Ser Ala Val Pro Glu Met Pro Ser Thr Trp Pro Pro Ala Thr
5360 5365 5370
Ala Arg Pro Phe Asp Val Gly Asp Leu Ala Asp Arg Leu Ala Arg
5375 5380 5385
Ala Gly His Thr Asp Gly Pro Ala Leu Pro Arg Pro Arg Ala Ala
5390 5395 5400
Trp Ala Asp Asp Asp Ala Val His Ala Glu Val Thr Leu Ala Asp
5405 5410 5415
Glu Gln His Ala Asp Val Glu Arg Tyr Gly Leu His Pro Ala Leu
5420 5425 5430
Leu Gly Ala Ala Leu Ala Leu Thr Arg Glu Gly Thr Asp Leu Pro
5435 5440 5445
Tyr Ala Phe Asp Asp Val Arg Val His Ala Thr Gly Ala Thr Thr
5450 5455 5460
Val Arg Val Ala Val Thr Ala Thr Gly Val His Leu Ala Asp Glu
5465 5470 5475
Thr Gly Ser Pro Val Ala Thr Val Gly Ala Val Arg Arg Arg Pro
5480 5485 5490
Leu Thr Val Glu Gly Ala Val Pro Gly Leu Leu Arg Pro Gly Leu
5495 5500 5505
Ala Glu Ile Pro Glu Leu Pro Pro Thr Thr Ala Thr Thr Gly Gly
5510 5515 5520
Leu Asp Asp Pro Ala Val Pro Asp Val Val Ile Leu Pro Ala His
5525 5530 5535
Gly Thr Gly Gly Ala Pro Leu Ala Glu Thr Arg Asp Leu Gly Ala
5540 5545 5550
Asp Val Leu Ala Ala Leu Arg Arg Phe Leu Thr Asp Asp Arg Tyr
5555 5560 5565
Ala Asp Ala Val Leu Ala Val His Thr Gly Pro Gly Leu Ala Pro
5570 5575 5580
Ala Ala Ala Ala Gly Leu Val Arg Thr Ala Gln Ala Glu His Pro
5585 5590 5595
Gly Arg Ile Val Val Val Asp Ala Glu Pro Asp Thr Ala Ala Pro
5600 5605 5610
Leu Leu Ala Ala Ala Ala Gly Leu Gly Glu Pro His Val Val Leu
5615 5620 5625
Arg Glu Gly Arg Ala Tyr Ala Arg Arg Leu Thr Pro Ala Val Pro
5630 5635 5640
Ser Gly Asp Ala Pro Ala Leu Asp Pro Asp Gly Thr Val Leu Ile
5645 5650 5655
Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Val Ala Arg His Leu
5660 5665 5670
Val Gly His Tyr Gly Val Arg Arg Leu Leu Met Leu Ser Arg Gly
5675 5680 5685
Gly Thr Ala Ser Asp Val Pro Gly Ala Glu Val Thr Ala Leu Ala
5690 5695 5700
Cys Asp Val Ala Asp Arg Asp Glu Leu Ala Ser Ala Leu Ala Gly
5705 5710 5715
Ile Asp Pro Ala His Pro Leu Thr Ala Val Val His Thr Ala Ala
5720 5725 5730
Val Ile Asp Asp Gly Val Leu Thr Ala Leu Thr Pro Glu Arg Leu
5735 5740 5745
Asp Thr Val Leu Arg Pro Lys Ala Asp Gly Ala Trp His Leu His
5750 5755 5760
Glu Leu Thr Lys Asp Gln Asp Leu Ala Ala Phe Val Leu Tyr Ser
5765 5770 5775
Ser Ala Ala Gly Val Leu Gly Ser Pro Gly Gln Gly Asn Tyr Ala
5780 5785 5790
Ala Ala Asn Ala Phe Leu Asp Glu Leu Ala Glu Gln Arg Arg Ala
5795 5800 5805
Thr Gly Leu Pro Ala Leu Ser Val Ala Trp Gly Leu Trp Glu Pro
5810 5815 5820
Glu Ser Gly Leu Thr Ala Gly Ala Gly Asp Arg Met Arg Arg Asp
5825 5830 5835
Gly Val Thr Ala Leu Ser Thr Glu Arg Gly Leu Ala Leu Leu Asp
5840 5845 5850
Ala Ala Leu Arg Ser Pro Asp Ala Ala Leu Val Ala Ala Asp Pro
5855 5860 5865
Ala Gly Leu Gly Ser Ser Ala Leu Phe Arg Ala Pro His Arg Gly
5870 5875 5880
Pro Arg Arg Arg Ala Ala Gly Ala Ser Ala Leu Ala Asp Arg Ile
5885 5890 5895
Ala Gly Leu Thr Ala Ala Asp Ala Glu Lys Ala Ala Leu Ala Val
5900 5905 5910
Val Arg Glu Cys Ala Ala Ala Val Leu Gly His Glu Gly Pro Ala
5915 5920 5925
Arg Ile Glu Ala Thr Ala Thr Phe Lys Glu Leu Gly Val Asp Ser
5930 5935 5940
Leu Thr Ala Val Arg Leu Arg Asn Ala Phe Thr Glu Ala Thr Gly
5945 5950 5955
Val Arg Leu Pro Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Gln
5960 5965 5970
Ala Val Ala Ala Lys Leu Thr Ala Ala Leu Thr Gly Arg Ala Pro
5975 5980 5985
Ala Arg Thr Arg Ala Thr Thr Ala Val Gly Gly His Asp Glu Pro
5990 5995 6000
Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ala
6005 6010 6015
Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly
6020 6025 6030
Ile Thr Ala Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Ala Leu
6035 6040 6045
Tyr Asp Pro Asp Pro Glu His Pro Gly Thr Ser Thr Val Arg His
6050 6055 6060
Gly Gly Phe Leu Ser Gly Ala Gly Asp Phe Asp Ala Gly Phe Phe
6065 6070 6075
Gly Ile Ser Pro Arg Glu Ala Ile Ala Met Asp Pro Gln Gln Arg
6080 6085 6090
Val Val Leu Glu Thr Ser Trp Glu Ala Leu Glu Gln Ala Gly Ile
6095 6100 6105
Val Pro Gly Thr Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly
6110 6115 6120
Ala Phe Ser Asp Gly Tyr Gly Leu Gly Thr Asp Leu Gly Gly Phe
6125 6130 6135
Gly Ala Thr Gly Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser
6140 6145 6150
Tyr Phe Tyr Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala
6155 6160 6165
Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ser Leu
6170 6175 6180
Arg Thr Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val
6185 6190 6195
Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser Gln Gln Arg Gly
6200 6205 6210
Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu Ala Ala Asp
6215 6220 6225
Gly Thr Ala Phe Ala Glu Gly Ser Gly Val Leu Val Val Glu Arg
6230 6235 6240
Leu Ser Asp Ala Glu Arg Arg Gly His Arg Ile Leu Ala Val Val
6245 6250 6255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
6260 6265 6270
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu
6275 6280 6285
Ala Asn Ala Gly Leu Arg Pro Ser Asp Val Asp Ala Val Glu Ala
6290 6295 6300
His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala
6305 6310 6315
Leu Leu Ala Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu
6320 6325 6330
Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly
6335 6340 6345
Val Ala Gly Ile Ile Lys Met Val Leu Ala Met Arg His Gly Ser
6350 6355 6360
Leu Pro Arg Thr Leu Tyr Val Asp Thr Pro Ser Ser His Val Asp
6365 6370 6375
Trp Thr Ala Gly Gly Val Glu Leu Leu Thr Asp Ala Arg Pro Trp
6380 6385 6390
Pro Ala Thr Thr Gly Pro Arg Arg Ala Ala Val Ser Ser Phe Gly
6395 6400 6405
Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ala His Ala Ala
6410 6415 6420
Pro Glu Pro Pro Ala Leu Asp Ser Pro Val Val Glu Pro Ser Ala
6425 6430 6435
Ser Leu Phe Ala Thr Glu Leu Thr Pro Leu Pro Val Ser Ala Arg
6440 6445 6450
Thr Ser Glu Ala Val Asp Gly Gln Val Gln Arg Leu Arg Glu His
6455 6460 6465
Leu Ala Thr His Pro Gly Asp Asp Pro Arg Ala Val Ala Ala Ala
6470 6475 6480
Leu Leu Ala Thr Arg Thr Asp Phe Pro His Arg Ala Val Leu Leu
6485 6490 6495
Gly Asp Gly Val Val Thr Gly Thr Ala Leu Thr Ala Pro Arg Thr
6500 6505 6510
Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Leu Gly Met Gly
6515 6520 6525
Arg Lys Leu Met Ala Glu Ser Pro Val Phe Ala Ala Arg Met Arg
6530 6535 6540
Gln Cys Ala Asp Ala Leu Ala Glu His Thr Gly Arg Asp Leu Ile
6545 6550 6555
Ala Met Leu Asp Asp Pro Ala Val Lys Ser Arg Val Asp Val Val
6560 6565 6570
His Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp
6575 6580 6585
Glu Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln
6590 6595 6600
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Glu
6605 6610 6615
Asp Gly Ala Arg Leu Val Ala Leu Arg Ser Ala Leu Leu Val Arg
6620 6625 6630
Glu Leu Ala Gly Arg Gly Ala Met Gly Ser Ile Ala Phe Ala Ala
6635 6640 6645
Ala Asp Val Glu Ala Ala Ala Ala Arg Ile Asp Gly Val Trp Val
6650 6655 6660
Ala Gly Arg Asn Gly Thr Ala Thr Thr Ile Val Ser Gly Arg Pro
6665 6670 6675
Asp Ala Val Glu Thr Leu Ile Ala Asp Tyr Glu Thr Arg Gly Val
6680 6685 6690
Trp Val Thr Arg Leu Val Val Asp Cys Pro Thr His Thr Pro Phe
6695 6700 6705
Val Asp Pro Leu Tyr Asp Glu Leu Gln Arg Ile Val Ala Ala Thr
6710 6715 6720
Thr Ser Arg Ala Pro Glu Ile Pro Trp Phe Ser Thr Ala Asp Glu
6725 6730 6735
Arg Trp Ile Asp Ala Pro Leu Asp Asp Glu Tyr Trp Phe Arg Asn
6740 6745 6750
Met Arg Asn Pro Val Gly Phe Ala Ala Ala Val Ala Ala Ala Arg
6755 6760 6765
Glu Pro Gly Asp Thr Val Phe Ile Glu Val Ser Ala His Pro Val
6770 6775 6780
Leu Leu Pro Ala Ile Asn Gly Thr Thr Val Gly Thr Leu Arg Arg
6785 6790 6795
Gly Gly Gly Ala Asp Arg Leu Leu Asp Ser Leu Ala Lys Ala His
6800 6805 6810
Thr Val Gly Val Ala Val Asp Trp Pro Thr Val Val Ala Ala Thr
6815 6820 6825
Gly Ala Ala His Asp Thr Ala Arg Thr Ala Asp Gly Ala Ala Thr
6830 6835 6840
Gly Thr Ala His Asp Leu Pro Thr Tyr Ala Phe His His Glu Arg
6845 6850 6855
Tyr Trp Ile Glu Pro Ser Ala Gly Thr Asp Ala Ser Gly Leu Gly
6860 6865 6870
Leu Asp Ala Val Asp His Pro Leu Leu Ala Ala Ser Val Ala Leu
6875 6880 6885
Pro Asp Ser Asp Glu Ala Leu Leu Thr Gly Arg Leu Ser Leu Ala
6890 6895 6900
Thr His Pro Trp Leu Ala Gly His Thr Val Asp Gly Glu Val Leu
6905 6910 6915
Leu Pro Gly Pro Val Phe Val Glu Leu Ala Gly Arg Gly Ala Asp
6920 6925 6930
Glu Ala Gly Cys Asp Leu Leu Asp Glu Leu Val Ile Glu Thr Pro
6935 6940 6945
Leu Ala Leu Pro Ala Thr Gly Ala Val Gln Val Arg Val Thr Val
6950 6955 6960
Ala Ala Ala Asp Asp Ala Gly Arg Arg Ala Val Arg Ile His Ala
6965 6970 6975
Arg Glu Asp Gly Gly Ser Thr Trp Thr Arg His Ala Ser Gly Tyr
6980 6985 6990
Ala Ala Ile Ala Thr Thr Glu Ser Ala Thr Ala Glu Gly Pro Trp
6995 7000 7005
Pro Pro Ala Arg Ala Glu Arg Ile Asp Ile Ala Glu Phe Tyr Arg
7010 7015 7020
Arg Leu Asp Ala Gly Gly Tyr Glu Phe Gly Pro Glu Phe Arg Gly
7025 7030 7035
Met Ser Ala Ala Trp Ser His Gly Asp Thr Val Tyr Ala Glu Val
7040 7045 7050
Ala Ile Asp Gly Ala Leu Ala Arg Asp Ala Ala Arg Tyr Thr Leu
7055 7060 7065
His Pro Ala Leu Leu Val Thr Ala Leu Gln Ala Gly Ser Leu Ser
7070 7075 7080
Ala Gly Ser Glu Asn Ala Gly Val Arg Leu Pro Phe Ala Phe Thr
7085 7090 7095
Gly Val Arg Val His Ser Ser Gly Ala Ala Lys Ala Arg Val Thr
7100 7105 7110
Phe Val Pro Gly Asp Gly Gly Ala Arg Val His Ile Ala Asp Glu
7115 7120 7125
Leu Gly Gln Leu Val Ala Glu Ile Gly Ser Phe Val Thr Arg Pro
7130 7135 7140
Leu Ala Glu Ala Asp Arg Gly Gly Asp Val Arg Leu Tyr Arg Arg
7145 7150 7155
Thr Trp Thr Gly Val Arg Ala Pro Ala Ala Pro Gly Thr Thr Ala
7160 7165 7170
Val Arg Tyr Ala Asp Leu Gly Asp Gly Ala Arg Ser Asp Ala Thr
7175 7180 7185
Leu Pro Asp Val Ala Ser Pro Asp Ala Thr Ser Pro Asp Val Val
7190 7195 7200
Leu Met Arg Ala Ser Asp Pro Ala Glu Val Arg Ala Ala Leu Asp
7205 7210 7215
Asp Pro Arg Thr Ala Asp Ala Thr Leu Val Val Ser Ala Glu Ala
7220 7225 7230
Gly Pro Val Ala Gly Ala Val Ala Ala Leu Leu Asp Ala Val Glu
7235 7240 7245
Pro Gly Arg Leu Val Leu Val Gln Thr Gly Asp Thr Val Thr Pro
7250 7255 7260
Arg Arg Ala Ala Ala Leu Ala Arg Leu Asp Glu Pro His Leu Arg
7265 7270 7275
Leu Thr Gly Gly Arg Leu Glu Ala Pro Arg Leu Thr Pro Ala Leu
7280 7285 7290
Thr Thr Thr Thr Pro Val Pro Tyr Gly Asp Val Val Leu Leu Asp
7295 7300 7305
Gly Gly Ser Glu Gly Leu Ala Arg Arg Leu Ser Glu His Gly Ala
7310 7315 7320
Glu Val Ile His His Glu Pro Gly Lys Leu Pro Gln Thr Pro Val
7325 7330 7335
Thr Ala Val Val His Ala His Gly Ala Ala Glu Ser Ala Trp Glu
7340 7345 7350
Leu His Arg Leu Thr Arg Asp Leu Pro Leu Thr Ala Phe Val Leu
7355 7360 7365
Val Val Pro Pro Gly Glu Ala Ala Gly Pro Trp Glu Ala Leu Ala
7370 7375 7380
Glu Leu Arg Arg Ala Glu Gly Leu Pro Ala Val Ala Phe Thr Ala
7385 7390 7395
Ala Glu Asp Arg Gln Thr Glu Leu Leu Asp Ala Ala Cys Ala Thr
7400 7405 7410
Gly Glu Ala Val Val Val Ala Thr Thr Pro Pro Arg Pro Gly Asp
7415 7420 7425
Pro Ser Pro Leu Trp Arg Pro Val Arg Arg Pro Ala Arg Arg Ser
7430 7435 7440
Ala Ala Asp Gly Gly Ser Leu Leu Glu Arg Leu Pro Asp Leu Ser
7445 7450 7455
Arg Lys Glu Gln Glu Gln Val Leu Leu Asp Val Val Arg Asp Thr
7460 7465 7470
Ala Ala Thr Leu Leu Gly His Ala Asp Ala Arg Ala Val Thr Ala
7475 7480 7485
Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Leu
7490 7495 7500
Gly Leu Arg Asp Arg Leu Ala Glu Ala Leu Gly Ile Pro Leu Pro
7505 7510 7515
Ala Thr Leu Val Phe Asp His Pro Ala Ala Gly Thr Leu Ser Arg
7520 7525 7530
His Leu Leu Thr Leu Leu Ala Pro Ala Asp Gly Asn Gly Thr Pro
7535 7540 7545
Ala Asp Gly Glu Pro Pro Ala Arg Ile Pro Ala Ser Ala Pro Ala
7550 7555 7560
Thr Asp Ser Glu Val Ala Ser Pro Asp Asp Glu Leu Ile Asp Asp
7565 7570 7575
Met Asp Ala Asp Ala Leu Ile Ala His Val Leu Lys Gly
7580 7585 7590
<210> 78
<211> 22776
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 78
ttgctgcgcg tgaatgccga gcggcacggc gaccgggtcg cctacacgga ttcccgacgc 60
gccgtgacgt acgagcggct ccagctcagg accggcagga tcgccggaca cctcgccgcg 120
tccggcgtgg gccgtggcga ccgcgtcgcg ctgctgctcg gcaacaggat cgagacgatc 180
gaggtctacc tcgccgccgc gcgtgccgcc gccgtcgcgg tgccgctcaa cccggacgcc 240
gccgacgccg agctcgccca cttcctgacg gactccggcg cgaccgtgct ggtcaccgac 300
gacctgcacc tcgaccaggt acgccggatc ggcaccgatg ccaccgtggt gctcgcaggg 360
cgacaggagc cgggctgcat cgcgtacgag gatttggcgg gaaccgaacc gccgcgcccg 420
ccccgagacg acctcggcct ggacgaaccc gcctggatgc tctacacgtc cggaaccacg 480
gggcgcccca agggcgtcgt ctccgcgcag cgcagcggcc tgtggtccgc gatgtactgc 540
gacgtgccgt cctggcagct caccgaggac gacgaactgc tctggcccgc cccgctgttc 600
cacagcctcg ggcaccatct ctgcctgctc gcggtcctca ccgtcggcgc gtccgcccgc 660
atcctcggcg gcttcgtcgc gcgtgacgtc ctcgacgcgc ttgccgaaca cccgtgcacc 720
gtgctggtcg gcgtgccgac gatgtaccgc tacctcctcg gtgccgtctc cggcgaacag 780
gagacccgcg cgctgcgcgt ggcgctggtc gcgggttcca ccgcaccggc gtcgctcacg 840
gcgggcttcg aagcggcgtt cggcgcgccg ctgctcgaca cctacggctg caccgagacc 900
accggatcgc tcaccgccaa caccctgacc gacgccaggg ttcccggctc gtgcgggctg 960
cccgtcccgg gcctttcgct gcggttcgtc gacccggtga ccggcgccga cgtggcgcgc 1020
ggcgacgagg gcgagctgtg ggcgagcgga ccgagcctca tgctcggcta ccacgcgcag 1080
accgaggcga ccgcccaggt gctcgtggac ggctggtacc gcaccggaga cctggcacgc 1140
caggcggaga ccgggcatgt gacgatcacc ggccgggtca aggaactcat catccgcggc 1200
ggggagaaca tccacccccg ggagatcgag tccgtggccc aggaggtgcc gggcgtcagg 1260
gacgccgccg cggcgggccg cccacacccc gtcctcggcg agatacccgt gctctacgtc 1320
gtgcccgaag gacccggcgt acccgtggaa gcgatcctcg cggagtgccg ccgccaactc 1380
gcctacttca aggtgcccga cgagatcctg cacgtcgcca cggtcccgcg caccgcgtcg 1440
ggcaaggtgc gccggggcga gctcgcgggc ctcccggccc gcctcgtcgg caccggcagc 1500
ggcgaggcgg cactgtgcga gctggtctgg gagcggcgcg agctgcccga cacggtgtcg 1560
caggctcgga cagtggtcac ccggcgggcg gtcgggatcg gccctgccga ggtaccggac 1620
acggaccagg ccctcctctg ggacgaagcg ctcgtgcgcc aggctgcgga gccggggtcg 1680
ttcgtactgg tggacacgga tgcggacaac ggtgacgagg ccgacgagct cgtcgccgcc 1740
gcggcggcgc tcggcgaacc ccaggtagcg ctgcgatccg gtgtggccta cgtgccgcgc 1800
ctcgtccgtg cgaacaccac ccccctgccc accacaccgt gggcgctgcg cccgcccgcc 1860
tccggcacgc tccgcgacct cgccgtcgtc ccctcggacg ccccgccgcg cccgctggcc 1920
gccggtgagg tccgcataga cgtccgcgcc gcggggctga acttccgcga cgtactgatc 1980
gcgctcggca cgtacccggg cgacggtgcg atgggcgggg aggccgccgg gatcgtgacc 2040
gaggtcgggc ccggcgtcga cgacctggtg cccggggccc acgtgttcgg tctcgtgcag 2100
gacgcgttcc ggcgcagcgt cgtcgcggac cggaggctgg tcgcgcggat cccgcgggac 2160
tggtcgttcc cggtcgccgc gtccgtgccc atcgtgttcg caacggcgtg gtacggcctc 2220
gtcgacgcgg gagaggtgcg gccgggccag aaggttctga tccacgcggc caccggtgga 2280
gtcggctcgg ccgcccggca gatcgcgcgg cacctgggtg cggaggtgta cgccaccgcg 2340
agccccgcca aacagcacct gctgctcacc gacggcttcg acgccgacca cgtcgcgaac 2400
tcccgtacga ccgcgttcgc cgacgcgttc cccccggtcg acgtcgtact gaactccctc 2460
accggcgaat tcctcgacgc ctccgtcgac ctgctcgcac cgggcggccg gttcgtcgaa 2520
atgggcaaga ccgacatccg tcacgacgtc caacagccct tcgacctgtc cgacgtcgac 2580
cccgcgcggc tgcgggagat cctcgaactg ctcctggagt tgttcgaccg cggcgagctg 2640
cgcccgctgc cggtgcggcc gtgggacatc cgccgtgcgc gggacgcgtt cgggtggatg 2700
agccaggcca ggaacaccgg caagacggtc ctcaccgtgc cgcatccgct cggtcccgac 2760
tcgccggtcc tggtcaccgg ggagggggcc gacgccgccg ccgggctgct gcgcgacgag 2820
acgggccgca cacacgtgtc cagcagcgct gcggaagccg agggggccga ggaagccgag 2880
cagggcgtga acgcgagcac gctcgcgcac gtcctgctcg gcgatccggc cggtgccgac 2940
gcgtatgccc ggtcccgggc cccggaaggg ctcccgatcg tcacggtcca cgggctgccc 3000
ggcatcgaac aggcgccgct gaccggtgag ttgctcgaag aggccatcga gggcggcggc 3060
tcgtacgtcg tcacccgggt cggttccgca ggggcgcggg ccgaggcgat ggcaggcgcg 3120
acgccaccga tcctctccgg actcgccgga gtggcgggac cggccgggcc gacagatcag 3180
gccgagcccg gcgccgcagg accggagtgg gcgagcctcc tcgcggcggc cgacgccgac 3240
cgggagaagg tactgctcga cctggtccgc gacagcgtcg ccacggtcct cggtctgccg 3300
ggcgccgaac gctgcgcgcc ggaccgtacg ttccgcgaga acggtctcga ctcactcacc 3360
actgtcgaat tcgcgaacac cgtcaccgcg cggacgggcc tgcgcgttcc cgcgtccacg 3420
gcgttcgacc accccacgcc gcgttcgttc gccgcgcacc tcgcgggctc tgtggcggcg 3480
cccgccgcca aggctgccct gggttccggt gaacctgtcg cgatcgtcgg gatggcctgc 3540
cgcctgcccg gcggcgtgac gtcccccgag gacctgtggc ggctcgtggc gtccggcacg 3600
gatgcgatca ccgagttccc cgccgaccgc ggctgggacg tcgacgcgct gttcgacccg 3660
gatccggacg cggtcggccg ttcgacgacc cgccacggtg gcttcctcac cgaggcaacc 3720
gggttcgacg ccgcgttctt tgggatcagc ccgaacgagg cgctggccat ggatccgcag 3780
cagcgtctgg tcctcgaaac ctcatgggag gcgttcgagc acgcggggat cgtcccggac 3840
acgctccggg agagcgacac cggcgtgttc atgggcgcgt tccaccaggg gtacggcgcg 3900
ggccgcgacc tgggcggact cggcgtcacg gcgacccaga cgagcgtcct gtccgggcgc 3960
ctctcatact tctacggact ccagggcccg gccgtgacgg tggacaccgc gtgctcgtcg 4020
tcgctggtcg cgctgcacca ggcggcgcag gcgctgcgtt cgggggagtg ctccctggcg 4080
ttggccggtg gtgtcacggt gatggcgaca ccggggagct tcgtggagtt ctcccggcag 4140
cgcgggctct ccccggacgg gcggtgcaag gcgttcgccg attcggcgga cggcaccggg 4200
ttcgccgaag gcgtcggtgt cctggttgtg gaacggctgt ccgacgcgga gcgcaacggt 4260
cacaccgttc tcgcggtcgt ccgtggttcg gcggtgaacc aggacggcgc gtccaacggc 4320
ctctccgcgc ccaacggtgt cgcccagcag cgcgtgatca ggcaggccct ggcgaacgcc 4380
gggctgaacg gcaccgacgt ggacgcggtc gaggcgcacg gtacgggaac ggtcctcggc 4440
gatccgatcg aggcgcaggc ggttctggcg acgtacgggc aagaacgtga agtcccgctg 4500
ctgctcggtt cggtcaagtc gaacgtcggt cacacccagg cggcggcggg cgtcgcgggt 4560
gtcatcaaga tggtgatggc gatgcggcgt ggggtggtgc cgcggacgtt gcacgtggac 4620
gagtcgtcgt cacatgtgga ctggtcggca ggggccgtcg aggtggtgac ggaggcacga 4680
ccgtggccgg agtcgggtgg ggcgcggcgt gcgggtgtgt cctcgttcgg tgtgagcggc 4740
acgaatgcgc atgtgatttt ggagggggtt gcggagtcgt cggttcgtag cggggggtcg 4800
tcggcgggtc tggtgccgtt gccggtgtcg gcgcgtacgg agtcgagctt ggcgttgcag 4860
gtggagcggc tcggcgagta tgtgcggggt ggggcggacc tgggcgcggt ggcggatggt 4920
ctggtgcgtg ggcgggcggt gttcggccgt cgggcggtgt tgctggggga gagcacggtt 4980
gccggagtcg ctgtggaggg ggcgcgaacg gtgttcgtgt tcccggggca gggctcgcag 5040
tgggtcggca tgggccggga gttgatgggc gtctcggagg tgttcgcggc gcggatgcgg 5100
gagtgtgcgg cggcgctgga gccgcacacg gggtgggatg tgctggatgt gctgggtgag 5160
gcggtggtgg ctgatcgggt ggaggtgttg cagcccgcgt cgtgggcggt ggcggtgagc 5220
ctggccgcac tgtggcaggc ccatggtgtg gtgccggatg cggtggtggg gcattcgcag 5280
ggggagatcg ccgcggcgtg tgtggcggga gcgttgagtc tggaggacgc cgcgcgggtc 5340
gtggccttgc gcagccagac catcgctgcg cggctggccg ggcacggggc gatggcgtca 5400
atcgccttgc ccgccagtgc cgttgaggtg atggaggggg tgtggatcgc ggcccgcaat 5460
ggtccggaat ccacggtggt cgcgggcgat ccggcggcgg tggagcgggt gctggcccgg 5520
tatgaggctg cgggtgtgcg ggtgcgccgg atcgcggtgg attacgcctc gcacaccccg 5580
cacgtggaag cgatccagga cgaactggcc gacgtcttag gggggatcac cagcagcgca 5640
ccttccgtcc cgtggtggtc gacggtcgac agcggctggg tgaccgaacc ggtcgatgac 5700
gactactggt accgcaacct gcgtcagccg gtggcgatgg ataccgcgac cggtgagctg 5760
gacggttcgc tgttcatcga gtgcagtgcc catccggtgc tgctgcccgc cctcgaccag 5820
gagcgcacgg tcgcttccct gcgtaccgat gacggtggct gggagcggtt cctgaccgcg 5880
ctcgccgagg cctggaccca gggcgcggac gttgactgga ccaccctgat cgagcccgcc 5940
cagcaccgcg tgttggacct gccgacctac cccttcgacc acaagcgcta ctggttgcag 6000
cccgccccgg cgggcggcgc ggggatcggc catccgttcc tgtcgagtgc ggcggtgctg 6060
ccgggcagcg acggcgtact actcacgggc aagctgtcgc tggccacgca cccgtggctg 6120
gccgatcacg ccgtgcagga cacggtgttg ctgccgggca cggcgttcct cgaactcgtg 6180
gtgcgggccg gtgacgaggt cggctgcgac accatcgacg aactggtcat cgagaccccg 6240
ctcgtactgc ccgtcaccgg tgccgtcgac ctcaccgtca ccgtcgacca gcccgacacc 6300
accggccacc gcccggtgag cgtccacgca cgccccgaag gaaccgacac ctggacccgc 6360
cacgtcaccg gcacactcac caccagcgcc accgacacca cccccgcccc gaactccttc 6420
ccgcaatggc ccccgaccgg cgcgcaaccg gcaagcctgg accagttcta cgagcagctc 6480
gcggccgcgg gctacaccta cggcccggcg ttccaggggc tgcgcgccgc atggcgggcg 6540
ggtgacacga tctacgccga ggtggcgctc cccgaggacc gtgccgccga tgtggaccgt 6600
ttcggagtgc acccggcgct tctggacgcg gccctgcatg ccgggcgcct cgacgcgggc 6660
gacgagttgg agctgccgtt ctcgtggacg ggcgtacgcc tgcacgccac cggcgccacc 6720
gccgtgcgcg tcgccctcac ccgaggccct gcgggcgtcg ccgtgcaggt ggccgatccg 6780
gacggccgcc ctgtcgtgtc cgtggacgcg ttggtgctgc ggccgcgcag cgccacgccg 6840
tcgggaccga acctgctcgg ccttgagtgg ttgccggtgg cggaggcgca ctacgacggt 6900
gccgacagcc tgcccgaggg ctacaccctc atcaccgcca cacaccccga cgaccccgaa 6960
gacgacccca ccaaccccca cagcacaccc acacgcaccc acacacaaac cacacgcgtc 7020
ctggccgccc tccaacacca cctcaccacc accaaccaca ccctcatcat ccacaccacc 7080
accgaccccc caggcgccgc cgtcaccggc ctcacccgca ccgcacaaaa cgaacaccca 7140
ggccgcatcc acctcataga aacccaccac ccccacaccc cactccccct cacccaactc 7200
accaccctca accaacccca cctacgcctc accaacaaca ccctccacac cccccacctc 7260
accccactca ccccccgcac caaccccaac cccaacccca acccccacca ccccacaaca 7320
cccaccccac ccctcaaccc ccaccacgcc atcctcatca ccggcggctc cggcaccctc 7380
gccggaatcc tcgcccgcca cctcaaccac ccccacacct acctcctctc ccgcacccca 7440
ccacccccca ccacacccgg cacccacatc ccctgcgacc tcaccgaccc cacccaaatc 7500
acccacgccc tcaaccagat accccaaccc ctcaccggca tcttccacac cgccgccacc 7560
ctcgacgaca cccccctgca caccctcacc ccccaacgcc tcaccaccgt cctccaaccc 7620
aaagccgacg ccgcctggca cctccaccac cacacccaaa accaacccct cacccacttc 7680
gtcctctact ccagcgccgc cgccaccctc ggcagccccg gccaagccaa ctacgccgcc 7740
gccaacgcct tcctcgacgc cctcgccacc caccgccaca cccacaacca acccgccacc 7800
accatcgcct ggggcatgtg gcacaccacc accacactca ccgggcaact cggcgacacc 7860
gaacggcagc gggtgcggga cggtttccgt ccgctcaccg aggccgaggg caaccacttc 7920
ctcgatgcga gcctcgccac cgacgtgccg ttcgtggtcg cggcgattcc cgccgagccc 7980
gctcgtcggc gggtcgagcg tcgtaccgtc cgtaccggtg aggacagcgg ccgcgacctg 8040
ctggccgtcg tgtgcggggc caccgccgcc gtactcggcc acgccgatgc ctccgagatc 8100
gggcccgcga ccgcgttcaa ggacctcggc atcgactcgc tcagcggcat ccggctgcgc 8160
aacagcctcg ccgagacgac cggcgtcagg ctctccgcga cggccgtctt cgaccacccg 8220
acgccggacg cgctcgccgc gcgtctcgcg gaggaactgc ggggcgatga ggaatcaccg 8280
ggggccgctg ccgctgccgc cgctcagagg accgtaccga cactggcggt ggcgggcgac 8340
gagccgctgg cgatcgtggc catggcctgc cggatgcccg gtggcgtgga cacgccggaa 8400
gacctgtggc gcctcgtcga atccggtggt gacgcgatca ccgagttccc caccgaccgc 8460
ggctgggacc tcgccgcgct ctacgatccg gaccccgacg cgatcggcaa ggtctccgtg 8520
cggcacggcg gcttcctcgc cggggcggcc gacttcgacg ccgagttctt cgggatcagc 8580
ccgcgcgagg ccctcgccat ggacccgcag cagcggctga tcctcgaagt gtcgtgggag 8640
gcgttcgagc gggcgggcat cctgcccgcg agcgtccgcg gcagcgacgc gggtgtgttc 8700
atgggcgcgt tcacgcaggg gtacggcgcg ggcgtcgacc tgggcggctt cggggcgacc 8760
ggcacgccga cgagcgtgct ctccgggcgg ctctcctact acttcgggct cgaaggccct 8820
tccgtcaccg tcgacacggc ctgctcgtcg tcactggtgg cgttgcacca ggccgcgcgt 8880
tcgctgcgct cgggggagtg ctcgctcgcg ctggtcggcg gtgtcacggt gatggcgacg 8940
acgaccgggt tcgtcgagtt ctcccgccag cgcgggctgg ctccggacgg ccgggccaag 9000
gcgttcgcgg acaccgccga cggcaccagt ttcgccgagg gcgccggtgt cctgatcgtc 9060
gagcggctct ccgacgccac ccgtctcggc cacccggtgc tcgcggtggt gcgcggctcc 9120
gccgtcaact ccgacggcgc gtcgaacggc ctttccgccc cgaacggccc cgcgcagcgg 9180
cgcgtcatcg agcgcgcgct cgatgacgcc gggctcgtac cgggcgacat cgacgccgtg 9240
gaggcgcacg gcaccggtac ccgtctcggc gatcccatcg aggcccaggc gctggaggcg 9300
gcgtacgggc tggaccgcgt gcatccgctg ctgatcggct cgctcaagtc gaacctcggc 9360
cacacccagg cagcggccgg cgtcgccggg gtgatcaaga tggtcctcgc gatgcggcac 9420
ggcgtcctgc cgcgcacgct gcacgtggac gaaccgtccc ggcacgtcga ctggggcggt 9480
ggtgtccggc tgctgcgccg caacgaaccg tggccggtca ccggccgcgt ccggcgcgcg 9540
ggcgtctcgt cgttcggcat cagcggtgcc aacgcccatg tcgtgatcga ggccgggccg 9600
cccgccgcac ccgccaccct tcccgccacc gaaccggtgc cggagggcgt cgtctggccg 9660
gtgtcggccc gcacacccga cggggtgcgg gacgtcgcgg gacgactggt cgcgctcacc 9720
gcccccgcgg ccgcgatcgg gcactcgctc gccaccaccc ggacggccat gcggcaccgg 9780
gcggtcgtgc ctgcacggga cgcggaggcg ttcgcccgcg gcgaggaagt gccgggcgtg 9840
gtgcggggaa ccgccgacgt caccgacgcg cgcgccgtgt tcgtgttccc cgggcagggt 9900
tcccagtggg acggcatggg cgcggaactg ctcgccaccg agcccgtgtt cgcgcggcgg 9960
ctcggcgagt gtgccgaggc gctcgccccg tacaccggat gggatctgct cgacgtcatc 10020
gcccggcggc ccggggcgcc cgcgctcgac cgggtcgacg tcgtgcaacc cgtgtcgttc 10080
gcgatgatgg tggcgctcgc cgaactgtgg cgctcgcgcg gggtcgcccc cgccgcggtg 10140
gtcggccact cccagggcga ggtcgccgcg gcctgcgtcg ccggggtgct cacactggac 10200
gacgccgcga aggtcgtcgc actgcgcagc cgactcgtcg ccaccgaact ggccgggcac 10260
ggcggcatgg tgtcggtgcc gcccgccgac ttcgacgcgg ccgcgtgggc cgggcgcctg 10320
gaggtcgccg cggtcaacgg gcccgcgtcg atcgtcgtcg ccggagcggc cgacgccgtc 10380
gaggaactgc tcgccgccac gccccacgcc cgccggatcg ccgtcgacta cgcctcgcac 10440
accgcgcacg tcgagaccat ccgcgatgcg ctgctcgacg cgctcgctga cctcaccccg 10500
ggtgcgccgg aggtcccgtt cttctccacc gtcgacgagg cgtggctcga ccgacccgcc 10560
gacgccgcct attggtacga caacgtacgc cgccccgttc gcttcggcgc cgcgaccgcc 10620
cgcctcgccg agctcggcta ccgcgtgttc gtcgaggcca gcccgcaccc ggtactcacc 10680
accgcgcttg cggacacgct cgccgggcat ccgaacacgg cggtgaccgg cacgctgcgg 10740
cggggcgacg gcggggcacg ccgcttcacc agctcgctcg ccgagctctg ggtccggggt 10800
gtgcccgtca gctggccgtc cggggagtcc cggagggtgc cgctgcccac gtacccgttc 10860
cggcgcgacc gctactggat cgacgcggaa ccggcaggca cctccgggca tccgctgctc 10920
ggctcgctgg tcgaacgcgc cgacggcgag ggcgcgttcg ccaccgcgct gttctcggtc 10980
cgtcgacagc cgtggctcgc cgaccacgag gtggacgggc ggatcatcgt gcccggctcg 11040
gcgctcgtgg aactgctcgc cgaagcgggg gcgcggctcg gcacgccgac gatcgcggag 11100
ctgacgatcg tcgcgccggt ggtggtcgac gaagagcgcg acacggagat ccagctcacg 11160
gtcggaaccg aggtgtcggg gcggcggccg gtgcgcctgc actgccggac cggcgcgggg 11220
ccgtggacgg tcggcgcgac cggcgcgctg agcgcggaca ccagcgatcc ggagccgttg 11280
gagtggcctc ccgccgacgc ggaaccggtc gacctgaccg gcttctacga cacgctgccg 11340
atctcgtacg ggcccgcgtt ccgggccatg acggcgatgt gggccgggca gggacgcgcc 11400
tacgcgtcgg tccgcctcgg cgagcagctc accgacgccc ggtacgggct gcaccccgtg 11460
ctgctcgacg cggccgtgca cgcgctcggc acgctcttcg cggacccgga gcggcccagg 11520
ctcgccttct cctggtccgg cgtacggatt cacgcgcgcg ccgcgaccac gctgcgcgtg 11580
ctgctcgaac gcgccgacgg cgacacgatc cgcatcctcg ccacggacga gcacggcgcc 11640
ccggtcctcg acgtggacgg cctgaccgtg cgggccgcgg aacccggcac cgaagcgctg 11700
ttcgaggtcg cctgggttcc cgtacccgcc tcgcccgtcc ccggctggac gtacctcgcc 11760
gatgtgcccg ggggcgacgt gtccgagggc gacttaatcg aaggcgacgt agtcgagggc 11820
ggtgtaggcg agagcgaccc gcccccggta gtggtccttc ccgtggagcc cggcgaccct 11880
ggcacctcgc ccggtgtccg ggcccgggag ctgggccgcg acctgctcgc gaccgtgcgg 11940
acgtggctcg ccgagccgcg ctgggcgcag tcccggctcg tcgtggtcac ccgtaccggc 12000
gaccccgcgc aggaggctct cggcggcctg gtccggacgg ccgggaccga acacccgggc 12060
cgcgtcggcc tgatcgaagc ggacgagatc acgcccgcca ccgtcgaggc cgggctcgcc 12120
gtcggcgacg agtcccacgt ccgggtcacc gacggcacgg tccgcgcggc ccggctgcgc 12180
cgtgtcaccg cgtccacggg agcatccccg ctgtccggcg ggaccgtgct cgtcaccggc 12240
ggcaccggcg ggctcggccg ccgcctcgtg gaccacctgc tgaccgcgca cgaggccgcc 12300
gaggtcgtcg tggcgtctcg cggcggccga cccgacggag cacctgagga cgaccgcgtg 12360
cggtacgtgg ccgccgacgt caccgaccgg gacgagctcg ccgccctcgt cgagggtgtc 12420
gccgagcggc tgtgcgccgt cgtccacatg gccggaatcg tcgacgacgc ggtcgtggcg 12480
accatgcggc cacagcagtg ggacgccgtg ctgcgggtca aggcggacgt cgcctggcag 12540
ctgcacgagc tgacgcgcgg cctcgaactc gccgcgttcg tcctgtactc gtccatctcc 12600
gcgacgttcg gcggggcggg gcaggcgaac tacgcgaccg gcaacgcgtt cctcgacgcg 12660
ctcgcccacc accggcggga ccaagggctg cccgcggtct cgctcgcgtg gggactgtgg 12720
gacgaggcgg acggcatggg cggacggctg accgccaccg atctgacccg tatcgcacgc 12780
ggcggcatga tcccgatgac ggccgagcag gggctcgcgc tgttcgacgc ggccctgcac 12840
agcgaccgcg ccgcactcgt gccggtccgg ctcgacctcg ccgccgtcgc cgcctcggac 12900
caggtcccgc cgatcctgcg cgacctcgta ccggccgccc ggcgcgcggc cgcaccgacg 12960
gccgcgcggg acatgctcga actcgtccgg acgagcgccg ccttggtgct cggccaccgc 13020
gacgcccacg ccatcgagcc gacgcgcgcg ttcaaggagg tgggcttcga ctcgctgacc 13080
ggcgtcgaac tgcgcaaccg gctggccgac gcgacgggcc tgaccttgcc cgccacgctc 13140
gtcttcgacc accccacggc ccaagcgctg gccgcacacc tggacgagct ggccggagcg 13200
aggaccgcca cccggcggcg cgcaccggcc ccggcccgcc gacatgacga gccgctggcg 13260
atcgtgggca tggcgtgccg gttgccgggt ggggtggcct ctcctgagga cctgtggcgg 13320
ttgttggagt cgggcggtga cgggatcacg accttccccg gggaccgtgg ctgggatgtg 13380
gaggcgctct acgatcccga tccggagcat ccgggtacgt cgacggtccg gcacggtgga 13440
ttcctgtccg gggcgggtga cttcgacgcc gggttcttcg gcatcagtcc gcgtgaggcc 13500
gtcgcgatgg acccgcagca acgtgtcgtc atggagacgt cgtgggaggc gctcgaatac 13560
gcgggcatcg acccgcacac gctgcggggc agtgacaccg gcgtgttcat ggggggctac 13620
ttctacgggt acggatccgg cgccgaccgc ggcggtttcg gcgcgacaag tacccagacc 13680
agtgtgctct cgggccgcct ttcgtacttc tacggtctgg agggcccggc ggtcacggtc 13740
gacaccgcct gctcatcgtc gctggtcgcg ctgcatcagg cagggcagtc gctgcgtacc 13800
ggcgaatgct cgctcgcgct ggtgggtggc gtgacggtga tggcgtcgcc gtccggattc 13860
gtggacttct cccagcagcg gggcctcgcg ccggacggtc ggtgcaaggc gttcgcggag 13920
gcggcggacg gtaccggctt cgccgagggt tccggggtcc tggtcgtgga gcggctctcc 13980
gacgcggagc gccacggcca ccgtgttctc gcggtcgtac ggggttccgc cgtcaaccag 14040
gacggcgcgt ccaacgggct ctccgcgccc aacgggccct cccaggaacg tgtcatccgc 14100
caggccctgg ccaacgcggg tctccagccc tcggatgtgg acgcggtcga ggcgcacggc 14160
accggcaccc gtctcggcga ccccatcgag gcgaccgcgc tcctcgcgac gtatgggcag 14220
gaccgggcga cgccgctcct gttgggttcg ctgaagtcca acatcggcca cacccaagcc 14280
gccgcagggg tcgcgggcat catcaagatg gtcctggcga tgcaccacga caccctgccg 14340
agcaccctcc atgtcgacac accctcctca cacgtcgact ggacggcagg caccgtcgaa 14400
ctcctcacgg atgcccgccc ctggcccgag accagcaggc cgcaccgcgc cgccgtgtcc 14460
tccttcggag tcagcggcac caacgcccac gtcatcctcg aaagccaccc ccgaccgact 14520
cccgcccccg acaccggatc cagcacccac cccgtacccc tgctcatctc agcccgcacc 14580
ccccgagcac tgagcgaaca caccacccgc gtaagcgcgt tcctcgacgc cgggggcggg 14640
gacgagcgcg cggtggcctc ggccctgctc acccgtaccg ccttcaccca ccgggccgcc 14700
ctgatcggca cggacctgat caccggcacg gcggtaccgg accgccgcct cgtgtggctc 14760
ttctccgggc agggctcgca gcgccccggc atgggcgacg aactggccgc cgcgtacgac 14820
gtgttcgccc gcacccgccg tgacgtcctc gacgccctcc aggtgcccgc cgggctcgac 14880
atccacgaca ccggttacgc ccagcccgcg gtgttcgcgc tccaggtcgc gctcagcgcc 14940
cagctcgacg cgtggggcgt acgcccggac gcgctcgtgg gccactcgat cggtgagctg 15000
gccgcggcgt acgtcgccgg tgtctggtcg ctcgacgacg cgtgcgcgtt ggtgtcggcg 15060
cgggcccggc tgatgcaggc gctgccgccc ggcggggcga tggccgcggt gatcgcgtcg 15120
gagcgggacg cgctgccgct gctgcgcgaa ggcgtggaga tcgccgcggt caacggtccc 15180
gcgtcgatcg tgctctccgg cgacgaggac gccgtgctcg acgtcgcggc ccggctcggc 15240
cgcttcaccc ggctgcggac cagccacgcg ttccactcgg cgcggatgga gccgatgctc 15300
gacgagttcc gggacgtcgc gcagcggctg acctaccacg agccgaagct cccgatggcc 15360
gcgggcgcgg actgcgcgac gccggagtac tgggtgcggc aggtccgtga caccgtccgg 15420
ttcggggagc aggtcgccgc gtacgacggg gcggcgctcc tggagatcgg cccggaccgg 15480
aacctggccc gtctcgtcga cggcatcccc gtgctgcacg gcgacgacga agcgcggtcc 15540
gcgatgaccg cgctcgcccg gctgcacacc ggcggcgtcg cggtcgactg gcccgaggtc 15600
atcggcgccg cgccgacgca cctgccgaac ctgccgacgt acccgttcga gcggacccgc 15660
tactggctcg gctcccgggc cgcgggcgac gcggcccagg ccgggcaact gccggtcgcc 15720
cacccggtgt tgaccgcggc ggtcatggtt cccggcacgg gcgacctggt gctcaccggc 15780
cgggtcgaag ccaccgaccc gctggcgcac tccgtgcacg gcatcccggt gctgtccgcc 15840
gcggtgctgc tcgacctggc gatcacggcg ggcggcgaag cgggctgcga cgccgtggag 15900
acgttcaccg tggacacccc ggtcacgctg ccgcagtccg gcgggctcgc gctctccgtc 15960
acggtggcgg cgccccggga agacggccgc cgcgcggtca ccgtgcacgc gcgacacggg 16020
acgggagagt ggaccgagca cgcgaccggg atcctcgccc gcgccgcgcg ggcggcgtcg 16080
gccgtgccgg agatgccgtc gacgtggccg cctgccaccg cccggccgtt cgacgtcggc 16140
gacctggccg accgcctggc cagggccggg cacacggacg gccccgcgct gccccggccg 16200
cgcgccgcct gggccgacga cgacgccgtc cacgccgaag tgaccctcgc cgacgagcag 16260
cacgccgatg tcgagcgata cggcctgcac ccggcgctgc tcggtgccgc gctcgccctc 16320
acccgggaag gcaccgacct tccgtacgcg ttcgacgacg tccgtgtcca cgcgaccggt 16380
gccacgacag tgcgggtcgc cgtcaccgcc accggtgtcc acctcgcgga cgagaccggg 16440
agtcccgtcg ccaccgtcgg cgcggtgcgc aggcgtcccc tgaccgtcga gggagccgtt 16500
cccggcctgt tgcggcccgg ccttgccgag ataccggaac tgccgcccac caccgcgacg 16560
accggtggac tcgacgaccc ggcggtcccg gacgtcgtca tactccccgc gcacggcacc 16620
ggcggtgccc cactcgccga gacccgcgac ctcggggccg acgtgctggc cgcgctgcgg 16680
cgcttcctca ccgacgaccg gtacgccgac gcggtcctgg ccgtgcacac cgggcccggc 16740
ctcgcccccg ccgcggccgc gggtctggtc aggaccgcgc aggcggagca ccccggccgg 16800
atcgtcgtcg tcgacgccga gccggacacc gccgccccgc tcctcgcggc ggccgccggg 16860
ctcggtgagc cgcacgtggt gctgcgcgaa ggccgggcgt acgcccgccg cctgaccccg 16920
gcggtcccgt cgggggacgc cccggcgctc gacccggacg gcaccgtcct catcaccggc 16980
gggtccggca ccctggcggg catcgtcgcc cgtcacctcg tcggccacta cggagtacgc 17040
cgtctgctga tgttgtcgcg cggcggcacg gcgagcgacg tccccggcgc cgaggtcacg 17100
gcgctcgcct gcgacgtcgc cgaccgggac gaactcgcct cggcactggc ggggatcgac 17160
cccgcgcacc ccctcacggc cgtcgtgcac accgcggccg tcatcgacga cggagtcctc 17220
accgcactca cccccgagcg gctggacacc gtgctgcgtc cgaaggccga cggagcctgg 17280
cacctgcacg aactcacgaa ggaccaggac ctcgcggcgt tcgtgctcta ctcctcggcc 17340
gccggagtac tcggcagccc cggacagggc aactacgccg ccgcgaacgc gttcctcgac 17400
gaactggccg aacagcgcag ggccaccgga ctgcccgcgc tgtccgtggc ctgggggctc 17460
tgggagccgg agagcggcct gacggccggg gccggggacc gcatgcgccg ggacggcgtc 17520
acggcgctga gcaccgaacg cggtctcgcg ctgctcgacg cggcgctgcg gtccccggac 17580
gcggcgctcg tcgccgcaga cccggcgggc ctcggcagtt cggccctgtt cagggcgccg 17640
caccggggcc cgcggcgccg cgcggccggt gcctccgctc tcgccgaccg gatcgcgggg 17700
ctgaccgcgg ccgatgcgga gaaggcggcg ctcgccgtcg tccgggagtg cgcggcggcc 17760
gtgctcggcc acgaaggacc cgcgcggatc gaggcgaccg cgacgttcaa ggaactcggc 17820
gtcgactccc tcacggcggt ccgattgcgc aacgcgttca ccgaggcgac gggcgtacgg 17880
ctcccggcca ccgcggtctt cgacttcccg acgccacaag ccgtcgcggc gaagctgacc 17940
gccgcgctga ccggccgggc accggcgcgg acccgcgcca cgaccgcggt cggcgggcat 18000
gacgagccgc tggcgatcgt gggcatggcg tgccggttgc cgggtggggt ggcatctcct 18060
gaggacctgt ggcggttgct ggagtcgggc ggtgacggca tcacggcgtt ccccgcggac 18120
cgtggctggg atgtggaggc gctctacgat cccgatccgg agcatccggg tacgtcgacg 18180
gtccggcacg gtggattcct gtccggggcg ggtgacttcg acgccggttt cttcggcatc 18240
agtccgcgtg aggccatcgc gatggacccg cagcaacgtg tcgtcctgga gacatcctgg 18300
gaggcgctcg aacaggcggg catcgtgccc ggcacgctcc gcgggagcga caccggcgtg 18360
ttcatgggcg cgttctccga cggatacgga ctcggcaccg acctcggcgg attcggcgcc 18420
accggcacgc agacgagcgt gctctcgggc cgtctttcgt acttctacgg tctggagggc 18480
ccggcggtca cggtcgacac ggcgtgttcg tcgtcgctgg tcgcgctgca tcaggcaggg 18540
cagtcgctgc gtaccggtga atgctcgctc gcgctggtcg gcggcgtcac ggtgatggcg 18600
tcgcccggtg ggttcgtcga gttctcccag cagcgcggac tcgcgccgga cgggcgctgc 18660
aaggcgttcg cggaggcggc ggacggtacc gctttcgccg agggttccgg ggtcctggtc 18720
gtggagcggc tctccgacgc cgagcgccgc ggccaccgta ttctcgcggt cgtacggggc 18780
tccgccgtca accaggacgg cgcctccaac ggcctctccg cgcccaacgg gccctcccag 18840
gaacgtgtca tccgccaggc cctcgcgaac gcgggcctcc ggccctcgga tgtggacgcg 18900
gtcgaggcgc acggcaccgg cacccgcctc ggcgacccca tcgaggcgac cgcgctcctc 18960
gcgacgtacg gacaggaccg ggcgacgccg ctcctgttgg gttcgctgaa gtccaacatc 19020
ggccacaccc aggccgccgc aggggtcgcg ggcatcatca agatggtcct ggcgatgcgg 19080
cacggttcgc tgccgcgcac cctgtatgtg gacacaccct cctcacacgt cgactggacg 19140
gcgggcggtg ttgaactcct cacggacgcc cggccctggc ccgccaccac aggccctcgc 19200
cgcgccgccg tgtcctcctt cggagtcagt ggcaccaacg cccacgtcat cctcgaagcc 19260
cacgcggctc cagagccacc ggccttggat tcaccggtgg tggagcccag cgcatcgctg 19320
ttcgccacgg agctcacacc actgcccgtc tcggcgcgga cctccgaggc cgtcgacggt 19380
caggtccaac ggctccgcga gcacctcgcc acccaccccg gcgacgaccc gcgtgccgtc 19440
gccgcggcgc tgctcgccac gcgtacggac ttcccgcacc gcgccgtact cctcggcgac 19500
ggcgtcgtca cgggcacggc gctcaccgcg ccgcgtaccg tcttcgtctt ccccggacag 19560
ggctcgcagt ggctcggcat gggccgcaaa ctgatggcgg agtccccggt gttcgcggcc 19620
aggatgcgcc aatgcgcgga cgccctggcc gagcacaccg ggcgggacct gatcgccatg 19680
ctcgacgacc ccgcggtgaa gagccgcgtc gacgtcgtgc accccgtgtg ctgggcggtc 19740
atggtgtcgc tggccgccgt gtgggaggcc gcgggcgtac gtccggacgc cgtcatcggg 19800
cactcccagg gcgagatcgc cgcggcctgc gtcgccgggg cgatctcgtt ggaggacggc 19860
gcccgcctcg tggcgctgcg cagcgcactg ctggtgcgcg agctcgcagg gcgcggcgcg 19920
atgggttcga tcgcgttcgc ggccgccgac gtcgaggcgg ccgccgcacg catcgacggc 19980
gtgtgggtcg cgggccgcaa cggcaccgcc accacgatcg tgtccggacg gccggacgcc 20040
gtcgagacgc tgatcgccga ctacgagacc cgcggcgtct gggtgacgcg gctcgtcgtc 20100
gactgcccga cccacacccc gttcgtcgac ccgctgtacg acgagctcca gcggatcgtc 20160
gcggccacca cctcgcgcgc ccccgagatc ccgtggttct ccaccgccga cgagcgctgg 20220
atcgacgcgc cgctcgacga cgagtactgg ttccgcaaca tgcgcaaccc cgtcggtttc 20280
gcggcggccg tggccgccgc ccgtgagccg ggcgacaccg tgttcatcga ggtcagcgcg 20340
cacccggtgc tgctgcccgc gatcaacggc acgaccgtcg gcacgctgcg ccgcggcggg 20400
ggagccgacc ggctgctcga ctcgctggcc aaggcgcaca ccgtcggagt ggccgtcgac 20460
tggcccacgg tcgtcgccgc gacgggggcg gcacacgaca ccgcgaggac ggcggacggc 20520
gccgcgacgg ggacggcaca cgacctgccc acgtacgcgt tccaccacga gcgctactgg 20580
atcgagccct ccgccggcac ggacgcttcc ggcctcgggc tcgacgccgt cgaccacccg 20640
ctgctcgccg cgtccgtggc gctgcccgac tccgacgagg cgctgctcac cgggcggctc 20700
tcgctcgcca cccacccgtg gctcgccggg cacaccgtcg acggcgaagt gctgctgccc 20760
gggcccgtgt tcgtggagct ggccgggcgc ggcgccgacg aagcgggctg cgacctgctc 20820
gacgaactgg tcatcgagac accgctcgcg ctgcccgcga ccggcgccgt ccaggtacgt 20880
gtgaccgtcg cggcggccga cgacgccgga cgccgcgccg tgcggatcca cgccagggag 20940
gacggtggga gcacatggac ccgccacgcc tcgggctacg cagccatcgc cacgaccgag 21000
tcggcgaccg ccgaagggcc ctggcccccc gcgcgtgcgg aacggatcga catcgcggag 21060
ttctaccggc gactcgacgc aggcgggtac gagttcggcc ccgagttccg cggcatgtcc 21120
gccgcgtgga gccacggcga caccgtctac gccgaggtgg ccatcgacgg cgccctcgcc 21180
agggacgccg cccgctatac gctgcacccg gcactgctcg tcaccgcgct ccaggcgggc 21240
agcctctccg cgggctccga gaacgcgggg gtacgactgc cgttcgcgtt caccggggtc 21300
cgcgtccact cgagcggcgc cgcgaaggca cgtgtcacgt tcgtgccggg agacggcggt 21360
gcccgcgtcc acatcgccga cgaactggga caactggtcg cggagatcgg gtcgttcgtc 21420
acccggcccc tcgccgaggc ggatcgcggc ggagacgtcc ggctgtaccg gcgtacgtgg 21480
accggcgtac gggctcccgc ggcacccggc accacagccg tccggtacgc cgacctgggc 21540
gacggcgcga ggtccgatgc caccttgccc gatgtggcct cgcccgacgc cacctcgccc 21600
gacgtcgtcc tcatgagggc atccgatccc gccgaagtcc gtgccgctct tgacgacccg 21660
aggaccgccg acgccacgct ggtcgtgtcc gccgaggccg gacccgtcgc cggtgccgtc 21720
gccgccctgc tcgacgccgt cgaaccggga cggctcgtgc tcgtgcagac cggagacacg 21780
gtgacgcccc gccgtgccgc cgccctcgcc cgactcgacg agccacacct gcgactgacc 21840
gggggacgcc tcgaagcgcc acgcctcacc ccggccctga caaccacgac tccggtgccg 21900
tacggcgacg tcgtgctcct cgacggcggt tcggaggggc tcgctcggcg gctgagcgaa 21960
cacggagccg aggtgatcca ccacgagccg ggcaagctgc cccagacccc ggtgaccgcg 22020
gtcgtccacg cgcacggcgc ggccgaatcg gcctgggagc tgcaccggct gacccgcgac 22080
cttccgctga ccgcgttcgt gctcgtggtt ccgcccggtg aggcggcggg gccgtgggaa 22140
gccctggccg agctgcgtcg ggcggagggg ctgcccgccg tggcgttcac cgcggccgag 22200
gaccggcaga ccgagctgct cgacgcggcg tgcgccaccg gggaagccgt ggtcgtggca 22260
accaccccgc cccggcccgg cgacccttcg ccgctgtggc ggccggtccg gcgtcccgcc 22320
cggcggtccg ccgccgacgg cggctccctg ctggaacgcc tgccggacct gtcgcgaaag 22380
gaacaggagc aggttctgct cgacgtcgtc cgtgacaccg cggccacgct gctcggccac 22440
gccgacgcgc gggcggtcac ggccaccgcg gcgttcaagg acctcggggt cgactcgctc 22500
accgcgctcg gcctgcgcga ccgcctcgcc gaggccctcg gcatcccgct gcccgccacg 22560
ctcgtcttcg accatccggc ggccggaacg ctcagccgac acctgctgac gctgctggcc 22620
ccggcggacg gcaacgggac cccggccgac ggtgagccac cggcacgaat acccgcgagc 22680
gctccggcaa ccgactcgga agtcgcatcg cccgacgacg aattgatcga cgacatggac 22740
gccgacgcgc tcatcgcgca cgtgctgaag ggatga 22776
<210> 79
<211> 332
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 79
Met Ser Ala Pro Val Ala Ala Pro Tyr Cys Arg Phe Glu Lys Ile Gly
1 5 10 15
Ser Pro Asp Leu Glu Asp Asp Glu Thr Val Leu Gly Val Ile Glu His
20 25 30
Gly Thr Gly His Thr Gly Ala Ser Leu Val Asp Gly Val Pro Arg Thr
35 40 45
Ala Leu His Thr Thr Thr Arg Asp Glu Glu Ala Phe Ala Glu Val Trp
50 55 60
His Ala Glu Pro Pro Val Glu Ser Gly Thr Asp Asp Gly Ile Ala Trp
65 70 75 80
Ala Arg Thr Gly Glu Tyr Leu Phe Gly Val Gly Arg Val Pro Glu Ser
85 90 95
Arg Arg Tyr Ala Asp Ala Val Ser Ala Leu Tyr Thr Arg Leu Phe Gly
100 105 110
Leu Thr Arg Ser Leu Gly Tyr Pro Leu Leu Ala Arg Thr Trp Asn Tyr
115 120 125
Val Ser Gly Ile Asn Ser Ala Asn Ala Asp Gly Leu Glu Val Tyr Arg
130 135 140
Asp Phe Cys Val Gly Arg Ala Gln Ala Leu Asp Glu Gly Gly Ile Asp
145 150 155 160
Pro Ala Ser Met Pro Ala Ala Thr Gly Ile Gly Thr His Gly Gly Gly
165 170 175
Ile Ala Cys Ala Phe Ile Ala Ala Arg Gly Gly Val Arg Val Asn Ile
180 185 190
Glu Asn Pro Ala Val Leu Thr Ala His His Tyr Pro Ala Ala Tyr Gly
195 200 205
Pro Arg Ser Pro Val Phe Ala Arg Ala Thr Trp Val Gly Pro Pro Asp
210 215 220
Gly Gly Arg Leu Phe Val Ser Ala Thr Ala Gly Ile Leu Gly His Glu
225 230 235 240
Thr Thr His His Gly Asp Val Thr Gly Gln Cys Glu Val Ala Leu Asp
245 250 255
Asn Ile Ala Arg Val Val Gly Ala Glu Asn Leu Arg Arg His Gly Ile
260 265 270
Arg Arg Gly His Val Leu Ala Asp Val Asp His Leu Lys Val Tyr Val
275 280 285
Arg Arg Arg Glu Asp Leu Ala Ala Val Arg Arg Val Cys Ala Ala Arg
290 295 300
Leu Ser Ser Thr Ala Thr Val Ala Ile Leu His Thr Asp Ile Ala Arg
305 310 315 320
Gly Asp Leu Leu Val Glu Ile Glu Gly Val Val Arg
325 330
<210> 80
<211> 999
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 80
atgtctgcgc ccgtcgcggc accgtactgc cgcttcgaga agatcgggtc gccggacctc 60
gaagacgacg agacggtact cggcgtcatc gaacacggca ccggccatac cggggcgtcg 120
ctggtggacg gcgtcccgcg aaccgccttg cacaccacga cccgtgacga ggaggcgttc 180
gccgaggtct ggcacgcgga gccgcccgtc gagtccggta cggacgacgg catcgcgtgg 240
gcccgcaccg gcgagtacct gttcggtgtg gggcgcgtcc ccgagagccg caggtacgcc 300
gatgccgtct cggcgctcta cacgcgcctc ttcgggctga cccggtcgct gggatacccg 360
ctgctcgccc gtacgtggaa ctacgtcagc ggcatcaact cggcgaacgc ggacggcctc 420
gaggtgtacc gggacttctg cgtgggccgc gcccaggcgc tcgacgaggg cggcatcgac 480
ccggcgagca tgcccgcggc caccggcatc ggcacgcacg ggggcggcat cgcctgcgcg 540
ttcatcgcgg cccgcggcgg ggtccgggtc aacatcgaga accccgccgt cctcacggca 600
caccactacc ccgcggcata cggcccgcgc tccccggtct tcgcgcgggc cacctgggtg 660
ggcccgccgg acggtggccg gctgttcgtt tccgcgacgg ccggcattct cggacacgag 720
acgacgcacc acggtgacgt gaccggtcag tgcgaggtcg ccctggacaa catcgcccgg 780
gtcgtcggcg cggagaacct gcgccgccac gggatccggc gggggcacgt cctcgccgac 840
gtcgaccacc tcaaggtcta cgtccgccgc cgcgaggacc tcgcggcggt gcgccgcgtc 900
tgcgccgccc gcctgtcgag caccgcgacc gtcgcgatat tgcacaccga catcgcccgc 960
ggcgacctgc tcgtcgaaat cgagggggtg gtgcggtga 999
<210> 81
<211> 1506
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 81
Val Thr Ser His Gly Lys Arg Pro Gly Thr Leu Arg Leu Gly Gly Ser
1 5 10 15
Pro Lys Lys Arg Asn Ser Thr Asn Arg Glu Ile Val Ala Ala Asp Arg
20 25 30
Ala Glu Pro Leu Leu Ala Ser Phe Ala Gln Arg Arg Ile Trp Phe Leu
35 40 45
Gln Gln Leu Asp Pro Asp Ser Asn Ala Tyr Asn Leu Pro Leu Val Arg
50 55 60
Arg Leu Arg Gly Pro Leu Asp Pro Ala Leu Leu Glu Arg Ala Leu Thr
65 70 75 80
Leu Val Val Ala Arg His Glu Ala Leu Arg Thr Val Phe Asp Ala Ala
85 90 95
Asp Gly Glu Pro Val Gln Arg Val Leu Pro Val Pro Ser Arg Ile Leu
100 105 110
Arg His Thr Arg Ala Asp Gly Glu Gln Gly Ala Ala Arg Leu Val His
115 120 125
Asp Glu Ile Ala Ala Pro Phe Asp Leu Ser Thr Gly Pro Leu Ile Arg
130 135 140
Ala Leu Leu Ile Arg Val Gly Asp Asp Asp His Val Leu Ala Val Thr
145 150 155 160
Val His His Val Ala Ala Asp Gly Trp Ser Phe Gly Leu Leu Gln Leu
165 170 175
Glu Leu Ala Ala His Cys Thr Ala Leu Arg Asp Thr Ser Arg Pro Ala
180 185 190
Val Leu Pro Pro Leu Pro Leu Gln Tyr Ala Asp Phe Ala Ala Trp Glu
195 200 205
Arg Arg Glu Leu Thr Gly Ala Gly Leu Glu Gln Arg Leu Ala Tyr Trp
210 215 220
Arg Asp Arg Leu Ser Gly Ala Pro Ala Val Leu Lys Leu Pro Thr Asp
225 230 235 240
Arg Pro Arg Pro Pro Val Ala Asp Ala Asp Ala Gly Met Val Glu Trp
245 250 255
Arg Pro Pro Ala Glu Leu Ala Ala Ala Val His Arg Leu Gly Arg Asp
260 265 270
Ala Gly Thr Ser Thr Phe Met Thr Leu Leu Ser Ala Phe Gln Leu Val
275 280 285
Leu Ala Arg His Ser Gly Thr Arg Asp Val Leu Val Gly Thr Pro Val
290 295 300
Ala Asn Arg Thr Arg Thr Glu Phe Glu Gly Leu Ile Gly Met Phe Val
305 310 315 320
Asn Thr Leu Ala Leu Arg Gly Asp Leu Ser Gly Asp Pro Ser Phe Arg
325 330 335
Glu Leu Leu Asp Arg Cys Arg Ala Thr Ala Thr Asp Ala Phe Ala His
340 345 350
Ala Asp Leu Pro Phe Glu Asn Leu Ile Glu Val Val Ala Pro Asp Arg
355 360 365
Asp Leu Ser Val Asn Pro Val Val Gln Val Leu Leu Gln Val Leu Arg
370 375 380
Arg Asp Ala Thr Thr Ala Ala Leu Pro Gly Val Thr Ala Glu Pro Phe
385 390 395 400
Gly Thr Gly Arg Trp Phe Thr Arg Phe Asp Leu Glu Phe His Val Tyr
405 410 415
Glu Glu Ala Asp Gly Ala Leu Thr Gly Glu Leu Arg Tyr Ser Arg Ala
420 425 430
Leu Phe Asp Glu Glu Arg Ile Thr Arg Leu Leu Asp Glu Phe Thr Ala
435 440 445
Val Leu Arg Ala Ala Ala Ala Ala Pro Asp Thr Arg Leu Ser Gln Leu
450 455 460
Pro Gly Asp Asp Ala Thr Pro Thr Pro Ala Ile Pro Ser Asn Asp Thr
465 470 475 480
Ala Arg Glu Leu Pro Val Asp Thr Leu Pro Glu Leu Leu Ala Gly Tyr
485 490 495
Ala Ala Arg Thr Pro Asp Ala Val Ala Val Thr Asp Pro Arg Thr Ser
500 505 510
Leu Thr Tyr Ala Asp Leu Asp Arg Arg Ala Asn Arg Leu Ala His Leu
515 520 525
Leu Arg Ala Arg Gly Thr Thr Thr Gly Asp Leu Val Gly Ile Cys Ala
530 535 540
Asp Arg Gly Val Asp Leu Val Val Gly Ile Val Gly Ile Leu Lys Ala
545 550 555 560
Gly Ala Ala Tyr Val Pro Leu Asp Pro Glu His Pro Pro Glu Arg Thr
565 570 575
Ala Phe Val Leu Ala Asp Ala Gln Leu Thr Ala Val Val Ala His Glu
580 585 590
Ala Tyr Arg His Arg Phe Ser Asp Val Pro His Val Val Thr Pro Asp
595 600 605
Asp Pro Asp Leu Asp Arg Gln Pro Asp Thr Ala Pro His Leu Thr Leu
610 615 620
Asp Arg Asp Ser Leu Ala Tyr Ala Ile Tyr Thr Ser Gly Ser Thr Gly
625 630 635 640
Lys Pro Lys Ala Val Leu Met Pro Gly Val Ser Ala Val Asn Leu Leu
645 650 655
Leu Trp Gln Glu Arg Thr Met Gly Arg Glu Pro Ala Ser Arg Thr Val
660 665 670
Gln Phe Val Thr Ala Thr Phe Asp Tyr Ser Val Gln Glu Ile Phe Ser
675 680 685
Ala Leu Leu Gly Gly Thr Leu Val Ile Pro Pro Asp Glu Ala Arg Phe
690 695 700
Asp Pro Pro Gly Leu Ala Arg Trp Met Asp Glu Gln Ala Ile Thr Arg
705 710 715 720
Ile Tyr Ala Pro Thr Ala Val Leu Arg Ala Leu Val Glu His Val Asp
725 730 735
Pro His Ser Asp Gln Leu Ser Ala Leu Arg His Leu Cys Gln Gly Gly
740 745 750
Glu Ala Leu Thr Leu Asp Ala Arg Leu Arg Glu Leu Cys Arg His Arg
755 760 765
Pro His Leu Arg Val His Asn His Tyr Gly Pro Ala Glu Ser Gln Leu
770 775 780
Ile Thr Gly Tyr Thr Leu Pro Ala Asp Pro Asp Thr Trp Pro Ala Ala
785 790 795 800
Ala Pro Ile Gly Pro Pro Ile Asp Asn Thr Arg Ile His Leu Leu Asp
805 810 815
Asp Ala Leu Arg Pro Val Pro Asp Gly Met Pro Gly Gln Leu Cys Val
820 825 830
Ala Gly Val Gly Leu Ala Arg Gly Tyr Leu Ala Arg Pro Glu Leu Thr
835 840 845
Ala Glu Arg Trp Val Pro Gly Gly Ala Thr Gly Glu Glu Arg Met Tyr
850 855 860
Leu Thr Gly Asp Leu Ala Arg Arg Ala Pro Gly Gly Asp Leu Asp Phe
865 870 875 880
Leu Gly Arg Ile Asp Asp Gln Val Lys Ile Arg Gly Ile Arg Ile Glu
885 890 895
Pro Gly Glu Ile Glu Asn Val Leu Ala Glu Asp Ala Arg Val Ala His
900 905 910
Ala Ala Val Ser Val Arg Glu Asp Pro Arg Gly Glu Lys Phe Leu Ala
915 920 925
Ala Tyr Val Val Pro Thr Ala Gly Pro His Gly Asp Gly Leu Ala Ala
930 935 940
Ser Leu Arg Glu Gly Leu Ala Asp Arg Leu Pro Ala Tyr Leu Val Pro
945 950 955 960
Ser Ala Val Val Ile Val Asp Ala Leu Pro Arg Thr Thr Ser Gly Lys
965 970 975
Val Asp Arg Arg Ala Leu Pro Asp Pro Ala Pro Asp Ser Ala Ala Pro
980 985 990
Arg Lys Val Ala Pro Arg Asn His Ala Glu Arg Val Val Cys Arg Ile
995 1000 1005
Phe Gln Asp Val Leu Gly Val Pro Arg Val Gly Ile Asp Asp Glu
1010 1015 1020
Phe Phe Ala Leu Gly Gly His Ser Leu Leu Ala Thr Arg Val Val
1025 1030 1035
Ser Arg Ile Arg Ala Glu Leu Gly Ala Asp Val Ala Leu Arg Thr
1040 1045 1050
Leu Phe Asp Ala Arg Thr Pro Ala Ala Leu Ala Arg Ala Val Asp
1055 1060 1065
Glu Ala Gly Pro Ala Ala Leu Pro Pro Ile Leu Pro Ser Pro Cys
1070 1075 1080
Ala Gly Pro Thr Pro Ile Thr Ala Ala Gln Glu Gln Met Leu His
1085 1090 1095
Ser His Gly Ser Leu Leu Ala Ala Pro Ser Tyr Thr Val Ala Pro
1100 1105 1110
Tyr Gly Phe Arg Leu Arg Gly Pro Leu Asp Arg Asp Ala Leu Asp
1115 1120 1125
Ala Ala Leu Thr Arg Ile Thr Ala Arg His Glu Pro Leu Arg Thr
1130 1135 1140
Gly Phe Arg Gly Arg Glu Gln Ile Val Gly Pro Pro Val Ala Val
1145 1150 1155
Arg Ala Glu Val Val Asp Val Pro Ser Gly Asp Val Gly Ala Ala
1160 1165 1170
Ala Arg Val Ala Arg Glu Glu Leu Ala Arg Pro Phe Asp Leu Val
1175 1180 1185
Ala Gly Pro Leu Leu Arg Ala Val Leu Leu Pro Leu Gly Thr Glu
1190 1195 1200
Asp His Val Leu Leu Leu Met Leu His His Leu Ala Gly Asp Gly
1205 1210 1215
Trp Ser Phe Asp Leu Leu Val Arg Glu Leu Ser Gly Ala Ser Pro
1220 1225 1230
Asp Leu Pro Val Ser Tyr Pro Asp Val Ala Arg Trp Glu Arg Ile
1235 1240 1245
Pro Ala Val Val Ala Ala Arg Glu Asp Asp Arg Ala Tyr Trp Arg
1250 1255 1260
Arg Gln Phe Glu Gly Ala Gly Ala Pro Glu Leu Pro Thr Val Arg
1265 1270 1275
Pro Arg Gly Thr Thr Ala Pro Asp Gly Arg Ala Phe Leu Trp Thr
1280 1285 1290
Phe Asp Asp Ala Thr Val Ala Ala Ala Arg Arg Val Ala Asp Ala
1295 1300 1305
Arg Asn Ala Thr Leu His Glu Thr Val Leu Gly Ala Phe Ala Leu
1310 1315 1320
Val Val Ala Glu Ala Ala Asp Ile Asp Asp Val Leu Val Ala Thr
1325 1330 1335
Pro Phe Ala Asp Arg Gly His Ala Gly Thr Asp His Leu Ile Gly
1340 1345 1350
Phe Phe Ala Lys Val Leu Ala Leu Arg Ile Asp Val Gly Lys Gly
1355 1360 1365
Ser Gly Gly Gly Gly Thr Pro Ser Phe Ala Glu Val Leu Arg Arg
1370 1375 1380
Val His Thr Ala Met Thr Gly Ala His Ala His Gln Ser Val Pro
1385 1390 1395
Tyr Ser Ala Met Arg Ala Ala Asp Pro Ala Leu Pro Pro Thr Pro
1400 1405 1410
Val Ser Phe Gln Leu Ile Ser Ala Leu Ser Thr Glu Leu Arg Leu
1415 1420 1425
Pro Gly Leu Arg Thr Glu Pro Phe Pro Val Val Ala Glu Thr Val
1430 1435 1440
Asp Glu Ile Asn Gly Glu Leu Ser Val Asn Leu Phe Asp Asp Gly
1445 1450 1455
Arg Thr Val Ser Gly Ala Val Val His Asp Ala Ala Leu Leu Asp
1460 1465 1470
Arg Ala Thr Val Asp Asp Leu Leu Thr Arg Val Glu Ser Thr Leu
1475 1480 1485
Arg Ala Ala Ala Gly Asp Leu Thr Val Arg Val Thr Gly Gln Val
1490 1495 1500
Gly Ser Glu
1505
<210> 82
<211> 4521
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 82
gtgacatcac acggaaagag gccgggcact ctgcgccttg gcggttcccc aaagaaacgg 60
aattcaacga atcgggaaat agtcgccgcc gaccgggccg agccgttgct cgcgtctttc 120
gcacagcggc gcatctggtt cctccagcaa ttggatccgg acagcaatgc ctacaatctt 180
ccgctcgtgc ggcgcctgcg cggtcctctt gacccggcgc ttctggagcg cgcgctcacg 240
ctcgtcgtgg cgcggcacga ggcattgcgg acggtgttcg acgccgcgga cggcgagccc 300
gtccagcggg tgcttcccgt cccgtcccgg atcctgcggc acacgcgggc cgacggcgag 360
cagggcgccg cccggctcgt ccacgacgag atcgccgcgc cgttcgacct ctccaccggg 420
ccgttgatca gggctctgct gatccgcgtc ggtgacgacg accacgtcct cgcggtgacc 480
gtgcaccatg tcgccgccga cggctggtcg ttcgggcttc tccagctcga actcgccgcg 540
cactgcacgg cacttcggga cacgtcccgt cccgccgtgc tgccgccgct gccgctgcag 600
tacgccgact tcgccgcctg ggagcggcgc gaactcaccg gcgccgggct cgaacagcgc 660
ctggcctact ggcgcgaccg gctcagcggc gcccctgccg tgctcaagct gcccaccgac 720
cgcccccgcc cgcccgtggc cgacgcggac gcgggcatgg tcgagtggcg gccaccggcc 780
gaactggccg ccgcggtcca ccgactgggc cgcgacgcgg gcacgtccac gttcatgacg 840
ctcctctcgg cgttccagct cgtcctcgcc cggcactcgg gcacccggga cgtgctggtc 900
ggcacgcccg tcgcgaaccg cacgcggacg gagttcgagg gcctgatcgg catgttcgtc 960
aacaccctcg cgctgcgcgg cgacctctcc ggcgacccgt cgttccggga gctcctggac 1020
cgctgccggg ccacggccac ggacgcgttc gcccacgccg acctgccgtt cgagaacctc 1080
atcgaggtcg tcgcaccgga ccgcgacctg tcggtcaacc cggtcgtcca ggtgctgctg 1140
caggtgttgc ggcgcgacgc cacgacggcc gcgctgcccg gcgtcacggc cgagccgttc 1200
ggcaccggcc gctggttcac ccgcttcgac ctcgagttcc acgtgtacga ggaggcggac 1260
ggcgctctca ccggtgaact ccgctacagc cgggcgctgt tcgacgagga acggatcacg 1320
cggctgctcg acgagttcac ggcggtgctg cgggcggccg ccgccgcacc cgacacacgg 1380
ctgtcccagc tgccaggtga cgacgcgacg ccgacacccg cgatcccctc gaacgacacg 1440
gcgcgggaac tgcccgtcga cacactgccg gaactgctgg ccgggtacgc cgcacggacc 1500
cccgacgccg tggccgtcac ggatccgcgg acctcactca cgtacgcgga ccttgaccgg 1560
cgcgcgaacc gcctcgcgca cctgctccgc gcgcgcggca ccaccaccgg cgacctcgtc 1620
ggaatctgcg ccgaccgcgg cgtcgacctc gtcgtcggca tcgtagggat cctcaaagcg 1680
ggtgccgcgt acgtgccgct cgatcccgaa cacccgccgg agcgcacggc gttcgtcctt 1740
gccgacgctc aactgaccgc ggtggtggca cacgaggcct accgccatcg gttctccgat 1800
gtgccgcacg tggtgacgcc cgacgacccg gacctcgacc ggcagccgga cacggcgccg 1860
cacctcacgc tcgaccggga cagcctcgcc tacgcgatct acacgtccgg ttcgaccggc 1920
aaacccaagg ccgtgctcat gcccggcgtc agcgccgtca acctgctgct ctggcaggag 1980
cgcacgatgg gccgcgaacc ggcgagccgc acggtccagt tcgtgaccgc cacgttcgac 2040
tactcggtcc aggagatctt ctccgcgctg ctcggcggca cgctcgtcat cccgccggac 2100
gaggccaggt tcgacccgcc gggactcgcc cggtggatgg acgagcaggc gatcacgcgg 2160
atctacgcgc cgacggccgt gctgcgcgcg ctggtcgaac acgtcgaccc gcacagcgat 2220
cagctctccg cgctccggca cctctgccag ggcggcgagg cgctgactct cgacgcgcgg 2280
ctgcgcgaac tctgccgaca ccggccccac ctgcgcgtcc acaaccacta cggcccggcc 2340
gagagccagc tcatcaccgg gtacacgctg cccgccgacc ccgacacgtg gcccgccgcc 2400
gcaccgatcg gtccgccgat cgacaacacc cgcatccatc tgctcgacga cgcgctgcga 2460
ccggttcccg acggcatgcc ggggcagctc tgcgtcgccg gcgtcggcct cgcccgcggc 2520
tatctcgccc gccccgaact gaccgccgag cgatgggtgc ccggcggcgc caccggcgag 2580
gaacgcatgt acctcaccgg cgacctggcc cgccgggcgc ccggcggcga cctcgacttc 2640
ctcggccgga tcgatgacca ggtcaagatc cgcggcatcc gcatcgagcc gggcgagatc 2700
gagaacgtcc tcgccgagga cgcccgcgtc gcacacgccg ccgtgtccgt acgcgaggat 2760
ccgcggggcg agaagttcct tgccgcgtac gtcgtgccga ccgccggtcc gcacggcgac 2820
ggcctcgccg cgtcgttgcg cgaaggtctt gccgaccggc tgcccgccta tctcgtgccg 2880
tccgccgtcg tcatcgtgga cgcgctgccc cggaccacga gcggcaaggt ggaccggcgc 2940
gcgctgcccg acccggcgcc cgactcggcg gcgccccgga aggtcgcgcc ccgcaaccac 3000
gccgaacggg tggtgtgccg gatcttccag gacgtgctcg gcgtcccgcg ggtcggcatc 3060
gacgacgaat tcttcgcgct cggcgggcat tccctgctcg ccacgcgagt cgtctcgcgg 3120
atccgcgccg agctgggtgc ggacgtcgcg ctgcggacgc tcttcgacgc acggaccccc 3180
gcggcgctcg cccgcgccgt ggacgaggca ggacccgccg ccctgccccc gatcctgccc 3240
tccccctgtg ccgggcccac ccccatcacc gccgcacagg agcagatgct gcactcgcac 3300
ggatccctgc tcgccgcccc ttcctacacg gtcgccccgt acgggttccg gctgcgcggg 3360
ccgctcgacc gcgacgcgct ggacgcggca ctgacccgga tcaccgcacg gcacgagccg 3420
ttgcggaccg gattccgggg ccgggagcag atcgtcgggc cgcccgtcgc ggtacgtgcc 3480
gaggtggtcg atgtgccgtc cggtgacgtc ggcgccgcgg cccgggtggc ccgcgaggag 3540
ctggcccggc cgttcgacct ggtggccgga ccgttgctgc gcgccgtgct cctgccgctg 3600
ggcaccgagg accacgtact gctgctgatg ctccatcacc tcgccggtga cggctggtcg 3660
ttcgacctcc tggtccggga actgtcgggg gcctcgcccg acctgccggt gtcctatcct 3720
gacgtggccc gctgggagcg gatcccggcc gtcgtcgcgg cgcgggagga cgaccgggcg 3780
tactggcgcc gacagttcga aggtgccggc gcgcccgagc tgcccacggt ccggccccgg 3840
ggcacgaccg cgccggacgg gcgggccttc ctctggacgt tcgacgacgc cacggtcgcg 3900
gcggcacgcc gggtcgccga tgccaggaac gcgacgctgc acgaaaccgt gctcggcgcc 3960
ttcgccctgg tcgtggccga ggccgccgac attgatgacg tgctcgtcgc gacgccgttc 4020
gcggaccggg ggcacgccgg gaccgaccac ctcatcgggt tcttcgcgaa ggtactcgcg 4080
ctgcgcatcg acgtcggcaa gggcagcggc ggcggtggca caccgtcgtt cgccgaggtc 4140
ctgcgccggg tgcacaccgc gatgaccggc gcccacgccc atcagtcggt gccctactcg 4200
gcgatgcgcg cggcggaccc cgcactgccg ccgactcccg tgtcgttcca gctcatcagc 4260
gcgctcagca cggaactgcg gctgcccggg ctgcgcaccg agccgtttcc cgtcgtcgcc 4320
gagaccgtcg acgagatcaa cggcgagctg tcggtcaatc tcttcgacga cggtcgcacc 4380
gtctcgggcg cggtcgtcca cgacgccgcg ctgctcgacc gcgcgaccgt cgacgacctg 4440
ctcactcggg tggagtcgac gttgcgcgcc gccgcaggcg acctcaccgt acgcgtcacc 4500
ggtcaagtgg gaagcgagta g 4521
<210> 83
<211> 6410
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 83
Val Pro Glu Gln Asp Lys Thr Val Glu Tyr Leu Arg Trp Ala Thr Thr
1 5 10 15
Glu Leu Gln Arg Thr Arg Ala Glu Leu Ala Ala His Ser Glu Pro Leu
20 25 30
Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro
35 40 45
Asp Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly Ile Gly Ala
50 55 60
Phe Pro Gly Asp Arg Gly Trp Glu Thr Gly Ala Asp Gly Arg Gly Gly
65 70 75 80
Phe Leu Ser Gly Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Val Ser
85 90 95
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Val Leu Glu
100 105 110
Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro His Thr Leu
115 120 125
Asn Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Phe Phe Gln Gly Tyr
130 135 140
Gly Ile Gly Ala Asp Phe Asp Gly Tyr Gly Thr Thr Ser Ile His Thr
145 150 155 160
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro
165 170 175
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
180 185 190
Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val
195 200 205
Gly Gly Val Thr Val Met Ala Ser Pro Ala Gly Phe Ala Asp Phe Ser
210 215 220
Glu Gln Gly Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu
225 230 235 240
Ala Ala Asp Gly Thr Ala Phe Ser Glu Gly Ser Gly Val Leu Val Val
245 250 255
Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Ile Leu Ala Val
260 265 270
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
275 280 285
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
290 295 300
Asn Ala Gly Leu Gln Pro Ser Asp Val Asp Ala Val Glu Ala His Gly
305 310 315 320
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala
325 330 335
Thr Tyr Gly Gln His Arg Thr Thr Pro Leu Leu Leu Gly Ser Leu Lys
340 345 350
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile
355 360 365
Lys Met Val Leu Ala Met His His Asp Thr Leu Pro Pro Thr Leu His
370 375 380
Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Thr Gly Gly Val Glu
385 390 395 400
Leu Leu Thr Asp Ala Arg Pro Trp Pro Thr Thr Thr Gly Pro Arg Arg
405 410 415
Ala Gly Ile Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
420 425 430
Leu Glu Ser Pro Thr Pro Val Pro Ser Pro Gly Ala Glu Pro Gly Ala
435 440 445
Arg Pro Val Pro Leu Pro Ile Ser Ala Arg Thr Pro Glu Ala Leu Asp
450 455 460
Glu His Thr Ile Arg Ile Arg Ala Phe Leu Asp Asp Asn Pro Gly Ala
465 470 475 480
Asp His Val Ala Val Ala Gln Thr Leu Ala Arg Arg Thr Pro Phe Glu
485 490 495
His Arg Ala Val Leu Leu Gly Asp Thr Leu Ile Thr Ala Asp Pro Asn
500 505 510
Ala Gly Ser Gly Pro Val Val Phe Val Tyr Ser Gly Gln Ser Thr Leu
515 520 525
His Pro His Thr Gly Arg Gln Leu Ala Ala Thr Tyr Pro Val Phe Ala
530 535 540
Asp Ala Trp Gly Glu Val Leu Gly His Leu Asp Ala Asp Gln Gly Pro
545 550 555 560
Ala Thr His Phe Ala His Gln Ile Ala Leu Thr Ala Leu Leu Arg Ser
565 570 575
Trp Gly Ile Ala Pro His Ala Val Ile Gly His Ser Leu Gly Glu Ile
580 585 590
Ser Ala Ala Cys Ala Ala Gly Val Leu Ser Leu Gly Asp Ala Ser Ala
595 600 605
Leu Leu Ala Ala Arg Ser Arg Leu Met Asp Glu Leu Pro Ala Gly Gly
610 615 620
Ala Met Val Thr Val Leu Thr Ser Glu Glu Asn Ala Leu Arg Ala Leu
625 630 635 640
Arg Pro Gly Val Glu Ile Ala Ala Val Asn Gly Pro His Ser Val Val
645 650 655
Leu Ser Gly Asp Glu Gly Pro Val Leu Ala Val Ala Gln Gln Leu Gly
660 665 670
Ile His His Arg Leu Pro Thr Arg His Ala Gly His Ser Ala Arg Met
675 680 685
Asp Pro Leu Val Ala Pro Leu Leu Glu Ala Ala Ser Gly Leu Thr Tyr
690 695 700
His Gln Pro Arg Ile Ala Ile Pro Gly Asp Pro Thr Thr Ala Ala Tyr
705 710 715 720
Trp Ala Arg Gln Val Arg Asp Gln Val Arg Phe Gln Ala His Ala Glu
725 730 735
Arg Tyr Pro Gly Ala Thr Phe Leu Glu Ile Gly Pro Asn Gln Asp Leu
740 745 750
Ser Pro Val Val Asp Gly Ile Pro Thr Gln Thr Gly Thr Pro Asp Glu
755 760 765
Val Gln Ala Leu His Thr Ala Leu Ala Arg Leu His Thr Arg Gly Gly
770 775 780
Val Val Asp Trp Pro Thr Val Leu Gly Gly Asp Arg Ala Pro Val Ala
785 790 795 800
Leu Pro Thr Tyr Pro Phe Gln His Lys Asp Tyr Trp Leu Arg Ala Thr
805 810 815
Ala Gln Ala Asp Val Thr Gly Ala Gly Gln Glu Gln Val Ala His Pro
820 825 830
Leu Leu Gly Ala Ala Val Ala Leu Pro Gly Thr Gly Gly Thr Val Leu
835 840 845
Thr Gly Arg Val Ser Leu Ala Ser His Pro Trp Leu Gly Gly His Ala
850 855 860
Val Asn Gly Thr Val Leu Leu Pro Gly Ala Ala Phe Leu Glu Leu Ala
865 870 875 880
Val Arg Ala Gly Asp Glu Ala Gly Cys Asp Leu Leu His Glu Leu Val
885 890 895
Val Glu Thr Pro Leu Thr Leu Pro Ala Thr Gly Ser Val Ala Ile Ser
900 905 910
Val Glu Val Ala Glu Pro Asp Asp Thr Gly Arg Arg Ala Val Thr Val
915 920 925
His Ala Arg Ala Asp Gly Ala Val Leu Trp Thr Arg His Ala Thr Gly
930 935 940
Phe Leu Gly Lys Ala Ala Ala Thr Thr Ala Glu Thr Gly Asp Pro Ala
945 950 955 960
Pro Trp Pro Pro Ala Gly Ala Arg Pro Val Asp Val Gly Asp Val Tyr
965 970 975
Glu Arg Phe Gly Ser Ile Gly Tyr Ala Tyr Gly Ser Ala Phe Gln Gly
980 985 990
Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr Val His Ala Glu Val Ala
995 1000 1005
Leu Pro Asp Glu Gln Gly Pro Asp Ala Ala Arg Phe Thr Leu His
1010 1015 1020
Pro Ala Leu Leu Asp Ala Ala Phe Gln Ala Gly Ala Leu Ser Ala
1025 1030 1035
Leu Asp Ala Pro Gly Glu Ala Ala Leu Leu Pro Phe Ser Phe Gln
1040 1045 1050
Asp Val Arg Ile His Ala Ala Gly Ala Thr Arg Ala Arg Val Thr
1055 1060 1065
Val Ser Arg Asp Gly Asp Arg Ser Thr Val Arg Met Thr Gly Glu
1070 1075 1080
Asp Gly Gln Pro Val Ala Glu Val Gly Ser Val Val Ser Arg Pro
1085 1090 1095
Tyr Ala Gly Gly Ser Gly Ser Asp Asp Glu Leu Leu Arg Pro Val
1100 1105 1110
Trp Thr Glu Leu Pro Met Pro Ala Pro Ser Ala Ala Asp Pro Arg
1115 1120 1125
Val Glu Val Leu Gly Ala Asp Pro Leu Asp Gly Glu Pro Ala Ala
1130 1135 1140
Ala Thr Arg Glu Leu Thr Ala Arg Val Leu Asp Ala Leu Gln His
1145 1150 1155
Arg Leu Ser Ala Thr Asp Asp Val Thr Leu Val Val Arg Ile Gly
1160 1165 1170
Thr Gly Leu Ala Ala Ala Ala Thr Ala Gly Leu Val Arg Ser Ala
1175 1180 1185
Gln Ala Glu Asn Pro Gly Arg Ile Val Leu Val Glu Ala Ser Pro
1190 1195 1200
Asp Thr Pro Ala Asp Leu Leu Thr Ala Cys Ala Ala Leu Asp Glu
1205 1210 1215
Pro Gln Leu Ala Val Arg Asp Gly Val Leu Phe Ala Pro Arg Leu
1220 1225 1230
Val Arg Met Ser Asp Pro Val His Gly Pro Leu Pro Leu Pro Asp
1235 1240 1245
Gly Asp Trp Leu Leu Thr His Ser Ala Ser Gly Val Leu His Asp
1250 1255 1260
Val Thr Leu Ala Val Asp Gly Thr Pro Arg Arg Ala Leu Glu Ala
1265 1270 1275
Gly Glu Val Arg Val Asp Val Arg Ala Ala Gly Leu Asn Phe Arg
1280 1285 1290
Asp Val Leu Ile Ala Leu Gly Thr Tyr Asp Gly Ala Thr Ala Leu
1295 1300 1305
Gly Gly Glu Ala Ala Gly Ile Val Val Glu Thr Gly Pro Gly Val
1310 1315 1320
Ala Asp Leu Ala Pro Gly Asp Arg Val Phe Gly Leu Thr Arg Gly
1325 1330 1335
Gly Ile Gly Pro Thr Ala Val Thr Asp Arg Arg Trp Leu Ala Arg
1340 1345 1350
Ile Pro Asp Gly Trp Ser Phe Thr Thr Ala Ala Ser Val Pro Ile
1355 1360 1365
Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Leu Ala Gly Leu
1370 1375 1380
Arg Ala Gly Glu Lys Val Leu Val His Ala Ala Thr Gly Gly Val
1385 1390 1395
Gly Met Ala Ala Thr Gln Leu Ala Arg His Leu Gly Ala Glu Val
1400 1405 1410
Tyr Ala Thr Ala Gly Thr Gly Lys Gln His Val Leu Arg Ala Ala
1415 1420 1425
Gly Leu Pro Gly Thr His Ile Ala Asp Ser Arg Thr Thr Ala Phe
1430 1435 1440
Arg Thr Asp Phe Pro Arg Met Asp Val Val Leu Asn Ser Leu Thr
1445 1450 1455
Gly Glu Phe Ile Asp Ala Ser Leu Glu Leu Leu Asp Ala Glu Gly
1460 1465 1470
Arg Phe Val Glu Met Gly Arg Ala Glu Leu Arg Asp Pro Asp Thr
1475 1480 1485
Ile Thr Pro Ala Tyr Leu Pro Phe Asp Leu Met Asp Ala Gly Thr
1490 1495 1500
Asp Arg Ile Gly Glu Ile Leu Gly Glu Leu Leu Gln Leu Phe Asp
1505 1510 1515
Ala Gly Ala Leu Thr Pro Leu Pro Val Arg Ala Trp Asp Val Arg
1520 1525 1530
Gln Ala Arg Asp Ala Leu Gly Val Met Ser Arg Ala Arg His Ile
1535 1540 1545
Gly Lys Asn Val Leu Thr Leu Pro Arg Pro Leu Asp Pro Glu Gly
1550 1555 1560
Ala Ile Val Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Leu
1565 1570 1575
Ala Arg His Val Ser Gly Gln His Val Tyr Leu Leu Ser Arg Thr
1580 1585 1590
Ala Pro Pro Glu Gly Thr Pro Gly Ile His Leu Pro Cys Asp Val
1595 1600 1605
Gly Asp Arg Gln Gln Leu Ala Ala Ala Leu Arg Arg Ile Asp Arg
1610 1615 1620
Pro Ile Thr Ala Val Val His Thr Ala Gly Ala Leu Asp Asp Gly
1625 1630 1635
Thr Leu Pro Ser Leu Thr Pro Glu Arg Phe Asp Thr Val Leu Arg
1640 1645 1650
Pro Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Lys Asp
1655 1660 1665
Gln Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser Ala Ala Gly Val
1670 1675 1680
Leu Gly Asn Ala Gly Gln Gly Asn Tyr Val Ala Ala Asn Ala Phe
1685 1690 1695
Leu Asp Ala Leu Ala Glu Gln Arg Gln Ala Ala Gly Leu Pro Ala
1700 1705 1710
Leu Ser Ile Ala Trp Gly Leu Trp Glu Asp Thr Ser Gly Leu Thr
1715 1720 1725
Ala Glu Leu Ser Glu Ala Asp Arg Gln Arg Met Arg Arg Ser Gly
1730 1735 1740
Phe Arg Thr Ile Ser Ala Arg Gln Gly Met Arg Leu Tyr Glu Ala
1745 1750 1755
Ala Arg Arg Thr Gly Ser Pro Val Val Val Ala Ala Ala Leu Asp
1760 1765 1770
Asp Ala Pro Asp Val Pro Leu Leu Arg Gly Leu Arg Arg Thr Thr
1775 1780 1785
Val Arg Arg Ala Thr Val Arg Glu Arg Ser Leu Ser Asp Glu Leu
1790 1795 1800
Ala Val Leu Pro Asp Asp Glu Arg Ala Asp Ala Leu Leu Ala Phe
1805 1810 1815
Val Arg Asn Ser Thr Ala Thr Val Leu Gly His Leu Gly Ala Glu
1820 1825 1830
Asp Ile Pro Ala Thr Ala Thr Phe Lys Glu Leu Gly Ile Asp Ser
1835 1840 1845
Leu Thr Ala Val Gln Leu Arg Asn Ala Leu Thr Thr Ala Thr Gly
1850 1855 1860
Val Arg Leu Asn Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Arg
1865 1870 1875
Ala Leu Ala Ala Arg Leu Gly Asp Glu Leu Ala Gly Thr Arg Ala
1880 1885 1890
Pro Val Ala Ala Arg Thr Ala Ala Thr Ala Ala Ala His Asp Glu
1895 1900 1905
Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1910 1915 1920
Ala Ser Pro Glu Gly Leu Trp Arg Leu Val Ala Ser Gly Thr Asp
1925 1930 1935
Ala Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala
1940 1945 1950
Leu Tyr Asp Pro Asp Pro Asp Ala Ile Gly Lys Thr Phe Val Arg
1955 1960 1965
His Gly Gly Phe Leu Asp Gly Ala Thr Gly Phe Asp Ala Gly Phe
1970 1975 1980
Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln
1985 1990 1995
Arg Val Leu Leu Glu Thr Ser Trp Glu Ala Phe Glu Ser Ala Gly
2000 2005 2010
Ile Thr Pro Asp Ser Ala Arg Gly Ser Asp Thr Gly Val Phe Ile
2015 2020 2025
Gly Ala Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp Thr Asn Gly
2030 2035 2040
Phe Gly Ala Thr Gly Ser Gln Thr Ser Val Leu Ser Gly Arg Leu
2045 2050 2055
Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ser Val Thr Val Asp Thr
2060 2065 2070
Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ser
2075 2080 2085
Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr
2090 2095 2100
Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser Arg Gln Arg
2105 2110 2115
Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Gly Ala Gly Ala
2120 2125 2130
Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Ala Leu Val Val Glu
2135 2140 2145
Arg Leu Ser Asp Ala Glu Arg His Gly His Thr Val Leu Ala Val
2150 2155 2160
Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
2165 2170 2175
Ser Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala
2180 2185 2190
Leu Ala Asn Ala Lys Leu Thr Pro Ala Asp Val Asp Ala Val Glu
2195 2200 2205
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln
2210 2215 2220
Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu
2225 2230 2235
Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ser
2240 2245 2250
Gly Val Ala Gly Ile Ile Lys Met Val Gln Ala Ile Arg His Gly
2255 2260 2265
Glu Leu Pro Pro Thr Leu His Ala Asp Glu Pro Ser Pro His Val
2270 2275 2280
Asp Trp Thr Ala Gly Ala Val Glu Leu Leu Thr Ser Ala Arg Pro
2285 2290 2295
Trp Pro Gly Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe
2300 2305 2310
Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu Glu Ala Gly Pro
2315 2320 2325
Val Lys Ala Gly Pro Val Glu Ala Gly Pro Val Pro Ala Ala Pro
2330 2335 2340
Pro Ser Ala Pro Gly Glu Asp Leu Pro Leu Leu Val Ser Ala Arg
2345 2350 2355
Ser Pro Glu Ala Leu Asp Glu Gln Ile Gly Arg Leu Arg Thr Tyr
2360 2365 2370
Leu Asp Thr Arg Pro Gly Val Asp Arg Ala Ala Val Ala Gln Thr
2375 2380 2385
Leu Ala Arg Arg Thr His Phe Ala His Arg Ala Val Leu Leu Gly
2390 2395 2400
Asp Thr Val Ile Thr Thr Ser Pro Ser His Gln Ala Asp Glu Leu
2405 2410 2415
Val Phe Val Tyr Ser Gly Gln Gly Thr Gln His Pro Ala Met Gly
2420 2425 2430
Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Glu Thr Trp His
2435 2440 2445
Asp Ala Leu Arg Arg Leu Asp Asp Pro Asp Pro His Asp Pro Thr
2450 2455 2460
Arg Ser Gln His Thr Leu Phe Ala His Gln Ala Ala Leu Thr Ala
2465 2470 2475
Leu Leu Arg Ser Trp Asp Ile Thr Pro His Ala Val Ile Gly His
2480 2485 2490
Ser Leu Gly Glu Ile Thr Ala Ala Tyr Ala Ala Gly Ile Leu Ser
2495 2500 2505
Leu Asp Asp Ala Cys Thr Leu Ile Thr Thr Arg Ala Arg Leu Met
2510 2515 2520
His Thr Leu Pro Pro Pro Gly Ala Met Val Thr Val Leu Thr Gly
2525 2530 2535
Glu Glu Glu Ala Arg Gln Ala Leu Arg Pro Gly Val Glu Ile Ala
2540 2545 2550
Ala Val Asn Gly Ala His Ser Val Val Leu Ser Gly Asp Glu Asp
2555 2560 2565
Ala Val Leu Asp Val Ala Gln Arg Leu Gly Ile His His Arg Leu
2570 2575 2580
Pro Ala Pro His Ala Gly His Ser Ala His Met Glu Pro Val Ala
2585 2590 2595
Ala Glu Leu Leu Ala Thr Thr Arg Arg Leu Arg Tyr Asp Arg Pro
2600 2605 2610
His Thr Ala Ile Pro Asn Asp Pro Thr Thr Ala Glu Tyr Trp Ala
2615 2620 2625
Glu Gln Val Arg Asn Pro Val Leu Phe His Ala His Thr Gln Gln
2630 2635 2640
Tyr Pro Asp Ala Val Phe Val Glu Ile Gly Pro Gly Gln Asp Leu
2645 2650 2655
Ser Pro Leu Val Asp Gly Ile Ala Leu Gln Asn Gly Pro Ala Asn
2660 2665 2670
Glu Ala His Ala Leu Arg Thr Ala Leu Ala Arg Leu Phe Ser Arg
2675 2680 2685
Gly Ala Thr Leu Asp Trp Pro Leu Val Leu Gly Gly Ala Ser Arg
2690 2695 2700
His Asp Pro Asp Val Pro Ser Tyr Ala Phe Gln Gln Arg Pro Tyr
2705 2710 2715
Trp Ile Glu Ser Ala Pro Pro Ala Thr Ala Asp Ala Gly His Pro
2720 2725 2730
Val Leu Gly Thr Gly Val Ala Val Ala Gly Ser Pro Gly Arg Val
2735 2740 2745
Phe Thr Gly Pro Val Pro Thr Gly Ala Asp Arg Ala Val Phe Ile
2750 2755 2760
Ala Glu Leu Ala Leu Ala Ala Ala Asp Ala Thr Asp Cys Ala Thr
2765 2770 2775
Val Glu Gln Leu Asp Ile Thr Ser Val Pro Gly Gly Ser Ala Arg
2780 2785 2790
Gly Arg Ala Ile Ala Gln Thr Trp Val Asp Glu Pro Ala Ala Asp
2795 2800 2805
Gly Arg Arg Arg Phe Thr Val His Ser Arg Val Gly Asp Ala Pro
2810 2815 2820
Trp Thr Leu His Ala Glu Gly Val Leu Arg Pro Gly Gly Val Pro
2825 2830 2835
Arg Pro Asp Ala Val Asp Ala Ala Trp Pro Pro Pro Gly Ala Val
2840 2845 2850
Pro Ala Asp Gly Leu Ser Arg Ala Trp Arg Arg Ala Asp Gln Val
2855 2860 2865
Phe Val Glu Ala Glu Val Asp Ser Pro Asp Gly Phe Val Ala His
2870 2875 2880
Pro Asp Leu Leu Asp Ala Val Phe Ser Ala Val Gly Asp Gly Ser
2885 2890 2895
Arg Gln Pro Thr Gly Trp Arg Asp Leu Ala Val His Ala Ser Asp
2900 2905 2910
Ala Thr Val Leu Arg Ala Cys Leu Thr Arg Arg Ala Gly Gly Val
2915 2920 2925
Val Glu Leu Ala Ala Phe Asp Gly Ala Gly Leu Pro Val Leu Thr
2930 2935 2940
Ala Glu Ser Val Thr Leu Gly Glu Val Ala Ser Ala Gly Gly Ser
2945 2950 2955
Asp Glu Ser Asp Gly Leu Leu Arg Leu Glu Trp Leu Pro Val Ala
2960 2965 2970
Glu Ala His Tyr Asp Gly Ala Asp Ser Leu Pro Glu Gly Tyr Thr
2975 2980 2985
Leu Ile Thr Ala Thr His Pro Asp Asp Pro Glu Asp Asp Pro Thr
2990 2995 3000
Asn Pro His Ser Thr Pro Thr Arg Thr His Thr Gln Thr Thr Arg
3005 3010 3015
Val Leu Ala Ala Leu Gln His His Leu Thr Thr Thr Asn His Thr
3020 3025 3030
Leu Ile Ile His Thr Thr Thr Asp Pro Pro Gly Ala Ala Val Thr
3035 3040 3045
Gly Leu Thr Arg Thr Ala Gln Asn Glu His Pro Gly Arg Ile His
3050 3055 3060
Leu Ile Glu Thr His His Pro His Thr Pro Leu Pro Leu Thr Gln
3065 3070 3075
Leu Thr Thr Leu Asn Gln Pro His Leu Arg Leu Thr Asn Asn Thr
3080 3085 3090
Leu His Thr Pro His Leu Thr Pro Leu Thr Ser Thr Gly Asn Pro
3095 3100 3105
Asn Pro His His Pro Thr Thr Pro Thr Pro Pro Leu Asn Pro Asp
3110 3115 3120
His Ala Ile Leu Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile
3125 3130 3135
Leu Ala Arg His Leu Asn His Pro His Thr Tyr Leu Leu Ser Arg
3140 3145 3150
Thr Pro Pro Pro Pro Thr Thr Pro Gly Thr His Ile Pro Cys Asp
3155 3160 3165
Leu Thr Asp Pro Thr Gln Ile Thr His Ala Leu Asn Gln Ile Pro
3170 3175 3180
Gln Pro Leu Thr Gly Ile Phe His Thr Ala Ala Thr Leu Asp Asp
3185 3190 3195
Thr Pro Leu His Thr Leu Thr Pro Gln Arg Leu Thr Thr Val Leu
3200 3205 3210
Gln Pro Lys Ala Asp Ala Ala Trp His Leu His His His Thr Gln
3215 3220 3225
Asn Gln Pro Leu Thr His Phe Val Leu Tyr Ser Ser Ala Ala Ala
3230 3235 3240
Thr Leu Gly Ser Pro Gly Gln Ala Asn Tyr Ala Ala Ala Asn Ala
3245 3250 3255
Phe Leu Asp Ala Leu Ala Thr His Arg His Thr His Asn Gln Pro
3260 3265 3270
Ala Thr Thr Ile Ala Trp Gly Met Trp His Thr Thr Thr Thr Leu
3275 3280 3285
Thr Ala His Leu Thr Asp Ser Asp Arg Asp Arg Ile Arg Arg Gly
3290 3295 3300
Gly Phe Leu Pro Ile Ser Asp Asp Glu Gly Met Arg Leu Tyr Asp
3305 3310 3315
Ala Ala Val Gly Ser Gly Glu Asp Tyr Val Leu Ala Ala Ser Met
3320 3325 3330
Asp Pro Ala Gln Pro Met Ser Gly Asp Val Pro Pro Ile Leu Ser
3335 3340 3345
Gly Leu Arg Arg Ser Ala Arg Arg Thr Ala Arg Thr Gly Gln Thr
3350 3355 3360
Phe Ala Gln Arg Leu Ala Glu Leu Pro Asp Ala Asp Arg Asp Thr
3365 3370 3375
Ala Leu Ser Thr Leu Val Met Asp Ala Thr Ala Ala Val Leu Gly
3380 3385 3390
His Ala Asp Ala Ser Glu Ile Gly Pro Thr Thr Thr Phe Lys Asp
3395 3400 3405
Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg Leu
3410 3415 3420
Ala Glu Ala Thr Gly Leu Arg Leu Ser Ala Thr Met Val Phe Asp
3425 3430 3435
His Pro Thr Pro Arg Val Leu Ala Ala Lys Leu Arg Thr Asp Leu
3440 3445 3450
Phe Gly Thr Ala Val Pro Thr Pro Thr Arg Thr Thr Arg Ala Arg
3455 3460 3465
His Asp Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro
3470 3475 3480
Gly Gly Val Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser
3485 3490 3495
Gly Thr Asp Ala Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp
3500 3505 3510
Ile Asp Arg Met Phe Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr
3515 3520 3525
Tyr Val Arg His Gly Gly Phe Leu Ser Glu Ala Ala Gly Phe Asp
3530 3535 3540
Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Trp Ala Met Asp
3545 3550 3555
Pro Gln Gln Arg Val Ile Leu Glu Thr Val Trp Glu Ala Phe Glu
3560 3565 3570
Asn Ala Gly Ile Val Pro Asp Thr Leu Arg Gly Ser Asp Thr Gly
3575 3580 3585
Val Phe Met Gly Ala Phe Ser His Gly Tyr Gly Ala Gly Val Asp
3590 3595 3600
Leu Gly Gly Phe Gly Ala Thr Ala Thr Gln Asn Ser Val Leu Ser
3605 3610 3615
Gly Arg Leu Ser Tyr Phe Phe Gly Met Glu Gly Pro Ala Val Thr
3620 3625 3630
Ile Asp Thr Ala Cys Ser Ser Ser Met Val Ala Leu His Gln Ala
3635 3640 3645
Ala Gln Ser Leu Arg Asp Gly Glu Cys Ser Leu Ala Leu Ala Gly
3650 3655 3660
Gly Val Thr Val Met Pro Thr Pro Leu Gly Tyr Val Glu Phe Cys
3665 3670 3675
Arg Gln Arg Gly Leu Ala Pro Asn Gly Arg Ala Lys Ala Phe Ala
3680 3685 3690
Glu Gly Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Val Leu
3695 3700 3705
Val Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val
3710 3715 3720
Leu Ala Leu Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser
3725 3730 3735
Asn Gly Ile Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile
3740 3745 3750
Arg Gln Ala Leu Asp Lys Ala Gly Leu Thr Pro Ala Asp Val Asp
3755 3760 3765
Val Val Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile
3770 3775 3780
Glu Ala Gln Ala Ile Ile Ala Thr Tyr Gly Gln Asp Arg Asp Thr
3785 3790 3795
Pro Leu Tyr Leu Gly Ser Val Lys Ser Asn Ile Gly His Thr Gln
3800 3805 3810
Thr Thr Ala Gly Leu Ala Gly Val Ile Lys Met Val Met Ala Met
3815 3820 3825
Arg His Gly Leu Leu Pro Lys Thr Leu His Val Asp Glu Pro Ser
3830 3835 3840
Ser His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Thr Glu
3845 3850 3855
Ala Arg Pro Trp Pro Asp Ser Asp Arg Pro Arg Arg Ala Gly Val
3860 3865 3870
Ser Ser Leu Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu
3875 3880 3885
Gly Val Ala Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly Leu
3890 3895 3900
Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Leu
3905 3910 3915
Gln Val Glu Arg Val Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu
3920 3925 3930
Gly Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Asp
3935 3940 3945
Arg Arg Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala
3950 3955 3960
Val Glu Gly Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser
3965 3970 3975
Gln Trp Val Gly Met Gly Arg Glu Leu Met Gly Ala Ser Glu Val
3980 3985 3990
Phe Ala Ala Arg Met Arg Glu Cys Ala Ala Ala Leu Glu Pro His
3995 4000 4005
Thr Gly Trp Asp Val Leu Asp Val Leu Gly Glu Ala Val Val Ala
4010 4015 4020
Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala Val Ala Val
4025 4030 4035
Ser Leu Ala Ala Leu Trp Gln Ala His Gly Val Val Pro Asp Ala
4040 4045 4050
Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
4055 4060 4065
Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Val Val Ala Leu Arg
4070 4075 4080
Ser Gln Thr Ile Ala Ala Arg Leu Ala Gly His Gly Ala Met Ala
4085 4090 4095
Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Ala Glu Gly Val
4100 4105 4110
Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala Gly
4115 4120 4125
Asp Pro Gly Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala
4130 4135 4140
Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr
4145 4150 4155
Pro His Val Glu Ala Ile Glu Glu Gln Leu Ala Asp Val Leu Gly
4160 4165 4170
Gly Ile Thr Ser Ser Ala Pro Asp Ile Ser Trp Trp Ser Thr Val
4175 4180 4185
Asp Ser Gly Trp Val Thr Glu Pro Val Gly Asp Asp Tyr Trp Tyr
4190 4195 4200
Arg Asn Leu Arg Gln Pro Val Ala Met Asp Thr Ala Ile Ser Glu
4205 4210 4215
Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser Ala His Pro Val Leu
4220 4225 4230
Leu Pro Ala Leu Asp Gln Glu His Thr Val Ala Ser Leu Arg Thr
4235 4240 4245
Asp Asp Gly Asp Trp Asp Arg Phe Leu Thr Ala Leu Ala Gln Ala
4250 4255 4260
Trp Thr Gln Gly Ala Pro Val Asp Trp Thr Thr Leu Ile Glu Pro
4265 4270 4275
Ala Pro His Arg Leu Leu Asp Leu Pro Thr Tyr Pro Phe Asp His
4280 4285 4290
Lys Arg Tyr Trp Ile Glu Ala Ala Ser Ala Thr Asp Leu Thr Ala
4295 4300 4305
Leu Gly Leu Thr Asp Thr Ala His Pro Met Leu Ala Ala Thr Ala
4310 4315 4320
Ala Leu Pro Thr Asn Asp Gly Thr Val Leu Thr Gly Arg Ile Ser
4325 4330 4335
Leu Arg Thr His Pro Trp Leu Ala Asp His Ala Ile Gln Asp Ser
4340 4345 4350
Val Leu Leu Pro Gly Thr Ala Phe Leu Glu Leu Val Val Arg Ala
4355 4360 4365
Gly Asp Glu Val Gly Cys Asp Thr Ile Asp Glu Leu Val Ile Glu
4370 4375 4380
Thr Pro Leu Val Leu Pro Val Thr Gly Ala Val Asp Leu Thr Val
4385 4390 4395
Thr Val Asp Gln Pro Asp Thr Thr Gly His Arg Pro Val Ser Val
4400 4405 4410
His Ala Arg Pro Glu Gly Thr Asp Thr Trp Thr Arg His Ala Thr
4415 4420 4425
Gly Thr Leu Thr Thr Ser Ala Thr Asp Thr Thr Pro Ala Pro Ser
4430 4435 4440
Ser Phe Pro Gln Trp Pro Pro Thr Ser Ala Ser Ala Ile Asp Ile
4445 4450 4455
Thr Glu Phe Tyr Ala Gln Leu Ala Val Leu Gly Tyr Arg Phe Gly
4460 4465 4470
Pro Thr Phe Arg Gly Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr
4475 4480 4485
Val Tyr Ala Glu Val Ala Leu Pro Glu Asp Arg Ala Ala Asp Ala
4490 4495 4500
Asp Arg Phe Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu Gln
4505 4510 4515
Ser Gly Ser Leu Leu Met Leu Ala Ser Asp Gly Glu Gln Gly Val
4520 4525 4530
Gln Leu Pro Phe Ser Trp His Gly Val Arg Phe His Ala Thr Gly
4535 4540 4545
Ala Thr Ser Leu Arg Val Thr Ile Val Pro Gly Pro Asp Gly Leu
4550 4555 4560
Arg Leu Arg Ala Ala Asp Ser Glu Asn His Pro Val Ala Thr Ile
4565 4570 4575
Asp Ala Leu Val Thr Arg Pro Pro Ala Asp Leu Ala Pro Ala Asp
4580 4585 4590
Pro Val Leu Arg Val Gly Trp Thr Ala Val Pro Val Pro Ala Glu
4595 4600 4605
Val Ser Pro Ser Asp Ala Asp Val Leu Thr Leu His Ser Asp Asp
4610 4615 4620
Ala Asp Pro Val Gln Glu Thr Arg Glu Leu Thr Thr Arg Val Leu
4625 4630 4635
Asp Ala Leu Leu Glu Val Glu Arg Thr Leu Ile Val Gln Val Thr
4640 4645 4650
Gly Gly Leu Ala Ala Met Ala Ala Ala Gly Leu Val Arg Thr Ala
4655 4660 4665
Gln Ser Glu Gln Pro Gly Arg Phe Phe Leu Val Glu Thr Asp Pro
4670 4675 4680
Gly Glu Val Leu Asp Ser Ala Arg Cys Asp Thr Ile Ala Ala Leu
4685 4690 4695
Gly Glu Pro Arg Leu Arg Leu Arg Asp Asn Arg Phe Glu Ala Ala
4700 4705 4710
Arg Leu Val Arg Ala Thr Pro Ala Leu Thr Pro Pro Asp Thr Gly
4715 4720 4725
Ser Trp Gln Leu Arg Gln Ser Ala Thr Gly Ser Leu Asp Asp Leu
4730 4735 4740
Ala Leu Val Pro Thr Asp Glu Pro Asp Arg Pro Leu Ala Ala Gly
4745 4750 4755
Glu Val Arg Ile Ala Val Arg Ala Ala Gly Leu Asn Phe Arg Asp
4760 4765 4770
Val Thr Val Ala Leu Gly Val Val Ala Asp Asp Arg Pro Leu Gly
4775 4780 4785
Ser Glu Ala Ala Gly Val Val Leu Glu Thr Gly Pro Gly Val His
4790 4795 4800
Asp Leu Ala Pro Gly Asp Arg Val Leu Gly Met Leu Ala Gly Ala
4805 4810 4815
Phe Gly Pro Val Ala Ile Thr Asp Arg Arg Leu Leu Gly Arg Val
4820 4825 4830
Pro Glu Gly Trp Thr Phe Pro Gln Ala Ala Ser Val Val Thr Val
4835 4840 4845
Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Leu Ala Glu Leu Arg
4850 4855 4860
Thr Gly Glu Lys Val Leu Ile His Ala Ala Ala Thr Gly Val Gly
4865 4870 4875
Ala Ala Ala Leu Gln Ile Ala Arg His Leu Gly Ala Asp Val Tyr
4880 4885 4890
Ala Thr Ala Ser Thr Pro Lys Gln His Leu Val Asp Leu Ala Pro
4895 4900 4905
Thr His Ile Ala Asp Ser Arg Ser Thr Ala Phe Ala Asp Thr Phe
4910 4915 4920
Pro Pro Ala Asp Val Val Leu Asn Ser Leu Thr Gly Glu Leu Leu
4925 4930 4935
Asp Ala Ser Thr Ala Leu Leu Thr Pro Gly Gly Arg Phe Ile Glu
4940 4945 4950
Met Gly Lys Thr Asp Ile Arg His His Ala Gln Gln Pro Phe Asp
4955 4960 4965
Leu Met Asp Ala Gly Pro Asp Arg Leu Gln Gln Ile Ile Thr Gln
4970 4975 4980
Leu Leu Asp Leu Phe Ala Asn Gly Thr Leu His Pro Leu Pro Val
4985 4990 4995
His Ala Trp Asp Val Arg Gln Ala Arg Glu Ala Phe Gly Trp Met
5000 5005 5010
Ser Ser Gly Arg His Thr Gly Lys Leu Val Leu Thr Val Pro Arg
5015 5020 5025
Pro Leu Asp Pro Glu Gly Ala Val Ile Ile Thr Gly Gly Ser Gly
5030 5035 5040
Thr Leu Ala Gly Ile Leu Ala Arg His Leu Asn His Pro His Thr
5045 5050 5055
Tyr Leu Leu Ser Arg Thr Pro Pro Pro Asp Thr Thr Pro Gly Thr
5060 5065 5070
His Leu Arg Cys Asp Val Ser Asp Pro Thr Gln Leu Ala Thr Ala
5075 5080 5085
Leu Ala Gln Ile Pro Gln Pro Leu Thr Gly Ile Phe His Thr Ala
5090 5095 5100
Ala Thr Leu Asp Asp Ala Leu Leu Asp Asn Leu Thr Pro Gln Arg
5105 5110 5115
Ile Asp Thr Val Leu Lys Pro Lys Ala Asp Ala Ala Trp His Leu
5120 5125 5130
His His Gln Thr Arg His Thr Asp Leu Thr Ala Phe Val Leu Tyr
5135 5140 5145
Ser Ala Val Ala Gly Val Met Gly Ser Pro Gly Gln Gly Asn Tyr
5150 5155 5160
Val Ala Ala Asn Ala Phe Leu Asp Ala Leu Ala Glu His Arg Gln
5165 5170 5175
Ala Arg Gly Leu Pro Ala Gln Ser Leu Ala Trp Gly Met Trp Ala
5180 5185 5190
Asp Val Ser Ala Leu Thr Ala Lys Leu Thr Asp Ala Asp Arg Glu
5195 5200 5205
Arg Ile Arg Arg Ser Gly Phe Pro Pro Leu Ser Ala Ala Asp Gly
5210 5215 5220
Met Arg Leu Phe Asp Ser Ala Ala Arg Thr Pro Glu Pro Val Val
5225 5230 5235
Val Ala Thr Thr Val Asp Val Thr Arg Leu Asp Gly Pro Val Ala
5240 5245 5250
Pro Leu Leu Arg Gly Leu Val Ala His Arg Ser Gly Pro Val Arg
5255 5260 5265
Ala Val Ala Arg Asn Ala Asp Asp Glu Pro Leu Ala Ala Arg Leu
5270 5275 5280
Ala Gly His Thr Ala Ala Glu Gln Arg Arg Val Met Gln Glu Val
5285 5290 5295
Val Leu Arg Gln Ala Ala Ala Val Leu Ala Tyr Gly Leu Gly Glu
5300 5305 5310
Gln Val Ala Ala Asp Arg Pro Phe Arg Asp Leu Gly Phe Asp Ser
5315 5320 5325
Leu Thr Ala Val Asp Leu Arg Asn Arg Leu Ala Ala Glu Thr Gly
5330 5335 5340
Leu Arg Leu Pro Thr Thr Val Val Phe Ser His Pro Thr Ala Glu
5345 5350 5355
Ala Leu Ala Thr His Leu Leu Glu Leu Leu Asp Ala Pro Ala Ala
5360 5365 5370
Leu Thr Ala Gly Ala Ser Leu Pro Ala Val Thr Ala Ala Pro Gly
5375 5380 5385
Thr Ala Ala Arg Asp Gln Asp Glu Pro Ile Ala Ile Val Ala Met
5390 5395 5400
Ala Cys Arg Leu Pro Gly Gly Val Thr Ser Pro Glu Glu Leu Trp
5405 5410 5415
Arg Leu Val Glu Ser Gly Thr Asp Ala Ile Thr Met Ala Pro Gly
5420 5425 5430
Asp Arg Gly Trp Asp Leu Asp Ala Leu Tyr Asp Pro Asp Pro Asp
5435 5440 5445
Ala Val Gly Lys Ala Tyr Asn Leu Arg Gly Gly Phe Leu Glu Gly
5450 5455 5460
Ala Ala Glu Phe Asp Ala Ala Phe Phe Asp Ile Ser Pro Arg Glu
5465 5470 5475
Ser Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ala
5480 5485 5490
Trp Glu Ala Ile Glu Arg Gly Arg Ile Asn Pro Ala Ser Leu His
5495 5500 5505
Gly Arg Glu Ile Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr
5510 5515 5520
Gly Leu Gly Ala Glu Asp Thr Glu Gly Asn Ala Ile Thr Gly Gly
5525 5530 5535
Ser Thr Ser Leu Leu Ser Gly Arg Leu Ala Tyr Val Leu Gly Leu
5540 5545 5550
Glu Gly Pro Ser Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
5555 5560 5565
Val Ala Leu His Leu Ala Cys Gln Gly Leu Arg Leu Gly Glu Cys
5570 5575 5580
Glu Leu Ala Leu Ala Gly Gly Val Ser Val Leu Ser Ala Thr Cys
5585 5590 5595
Cys Ala Ala Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala
5600 5605 5610
Asp Gly Arg Cys Lys Ser Phe Gly Ser Gly Ala Asp Gly Thr Thr
5615 5620 5625
Trp Ala Glu Gly Val Gly Val Leu Val Leu Glu Arg Leu Ser Asp
5630 5635 5640
Ala Glu Arg Leu Gly His Thr Val Leu Ala Val Val Arg Gly Ser
5645 5650 5655
Ala Val Thr Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn
5660 5665 5670
Gly Leu Ala Gln Gln Arg Val Ile Arg Lys Ala Leu Ala Ala Ala
5675 5680 5685
Gly Leu Thr Ala Ala Asp Val Asp Leu Val Glu Gly His Gly Thr
5690 5695 5700
Gly Thr Arg Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Leu Ala
5705 5710 5715
Thr Tyr Gly Gln Asn Arg Gln Glu Pro Val Trp Leu Gly Ser Leu
5720 5725 5730
Lys Ser Asn Ile Gly His Ala Thr Ala Ala Ala Gly Val Ala Gly
5735 5740 5745
Val Ile Lys Thr Val Gln Ala Ile Gly Ala Gly Thr Met Pro Arg
5750 5755 5760
Thr Leu His Ala Asp Glu Pro Ser Pro Ala Val Asp Trp Thr Ala
5765 5770 5775
Gly Arg Val Ser Leu Leu Thr Gly Asn Arg Pro Trp Pro Asp Asp
5780 5785 5790
Glu Arg Ala Arg Arg Ala Ala Val Ser Ala Phe Gly Leu Ser Gly
5795 5800 5805
Thr Asn Ala His Val Ile Leu Glu Gln His Arg Pro Glu Pro Val
5810 5815 5820
Ala Pro Arg Pro Pro Arg Glu Glu Pro Arg Pro Leu Pro Trp Val
5825 5830 5835
Leu Ser Ala Arg Thr Pro Ala Ala Leu Arg Ala Gln Ala Ala Arg
5840 5845 5850
Leu Arg Asp His Leu Ala Ala Val Pro Asp Ala Asp Pro Leu Asp
5855 5860 5865
Ile Gly Tyr Ala Leu Ala Thr Ser Arg Ala Arg Phe Thr His Arg
5870 5875 5880
Ala Ala Val Val Ala Thr Ser Ser Asp Glu Phe Arg Ala Gly Leu
5885 5890 5895
Asp Ser Val Ala Asp Gly Val Glu Ala Pro Gly Val Val Gly Gly
5900 5905 5910
Thr Ala Arg Glu Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly
5915 5920 5925
Ala Gln Arg Val Gly Met Gly Arg Glu Leu His Gly Arg Phe Pro
5930 5935 5940
Val Phe Ala Ala Ala Trp Asp Glu Val Ser Asp Ala Phe Gly Lys
5945 5950 5955
His Leu Glu His Ser Pro Thr Asp Val Phe His Gly Glu His Gly
5960 5965 5970
Asp Leu Ala His Asp Thr Leu Tyr Ala Gln Val Gly Leu Phe Thr
5975 5980 5985
Leu Glu Val Ala Leu Leu Arg Leu Leu Glu His Trp Gly Val Arg
5990 5995 6000
Pro Asp Val Leu Val Gly His Ser Val Gly Glu Val Thr Ala Ala
6005 6010 6015
Tyr Ala Ala Gly Val Leu Thr Leu Ala Asp Ala Thr Ala Leu Ile
6020 6025 6030
Val Ala Arg Gly Arg Ala Leu Arg Ala Leu Pro Pro Gly Ala Met
6035 6040 6045
Thr Ala Val Asp Gly Ser Pro Ala Glu Val Gly Ala Phe Thr Gly
6050 6055 6060
Leu Asp Ile Ala Ala Val Asn Gly Pro Ser Ala Val Val Leu Thr
6065 6070 6075
Gly Ser Pro Asp Asp Val Thr Ala Phe Glu Arg Glu Trp Ala Ala
6080 6085 6090
Ala Gly Arg Arg Ala Lys Arg Leu Asp Val Gly His Ala Phe His
6095 6100 6105
Ser Arg His Val Asp Gly Ala Leu Asp Asp Phe Arg Thr Val Leu
6110 6115 6120
Glu Ser Leu Ser Phe Gly Ala Ala Arg Leu Pro Val Val Ser Thr
6125 6130 6135
Thr Thr Gly Arg Asp Ala Ala Gly Asp Leu Ala Thr Pro Glu His
6140 6145 6150
Trp Leu Arg His Ala Arg Arg Pro Val Leu Phe Ala Asp Ala Val
6155 6160 6165
Arg Glu Leu Ala Asp Leu Gly Val Asn Met Phe Val Ala Val Gly
6170 6175 6180
Pro Ser Gly Ala Leu Ala Ser Ala Ala Ser Glu Asn Thr Gly Gly
6185 6190 6195
Ser Ala Gly Thr Tyr His Ala Val Leu Arg Ala Arg Thr Gly Glu
6200 6205 6210
Glu Asn Ala Ala Leu Thr Ala Val Ala Glu Leu His Ala His Gly
6215 6220 6225
Ala Pro Val Asp Leu Ala Ala Val Leu Ala Gly Gly Arg Pro Val
6230 6235 6240
Asp Leu Pro Val Tyr Pro Phe Gln His Arg Ser Tyr Trp Leu Ala
6245 6250 6255
Pro Ala Val Gly Gly Gly Ser Pro Thr Ala Val Pro Asp Thr Gly
6260 6265 6270
Arg Pro Ala Glu Pro Asp Pro Asp Asp Leu Thr Val Ala Glu Ile
6275 6280 6285
Val Arg Arg Arg Ala Ala Ala Leu Leu Gly Ile Ala Asp Pro Gly
6290 6295 6300
Asp Val Asp Ala Asp Thr Thr Phe Phe Ala Leu Gly Phe Asp Ser
6305 6310 6315
Leu Ala Val Gln Arg Leu Arg Asn Gln Leu Thr Ala Ala Thr Gly
6320 6325 6330
Leu Asp Leu Pro Thr Ala Val Leu Phe Asp His Asp Thr Pro Ser
6335 6340 6345
Ala Leu Thr Ala Tyr Leu Glu Glu Gln Leu Gly Asp Gly Ala Asp
6350 6355 6360
Asp Asp Ala Pro Thr Val Leu Ala Leu Leu Ala Glu Met Glu Ser
6365 6370 6375
Leu Asp Ala Ala Asp Ile Ala Ala Thr Pro Ala Pro Glu Arg Ala
6380 6385 6390
Ala Ile Ala Asp Leu Leu Asp Lys Leu Ser Arg Thr Trp Lys Asp
6395 6400 6405
His Arg
6410
<210> 84
<211> 19227
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 84
gtgcccgaac aggacaaaac ggtcgagtac ctccgctggg ccaccacgga actgcagagg 60
acccgggcgg aactcgccgc gcacagcgag cccttggcga tcgtgggcat ggcctgccgc 120
ctgccgggcg gggtggcgtc gccggacgat ctgtggcggc tcctggagtc cggcggcgac 180
ggcatcggcg ccttccccgg agaccgcggc tgggagaccg gcgccgacgg gcgcggcgga 240
ttcctgtccg gggcggccgg gttcgatgcc gcgttcttcg gcgtcagtcc gcgtgaggcg 300
ctggcgatgg atccgcagca gcgcgtcgtc ctggagacgt cgtgggaggc gctcgaacac 360
gcgggcatcg acccgcacac actgaacggc agcgacaccg gggtgttcct gggggcgttc 420
ttccaggggt acggaatcgg tgccgacttc gacgggtacg gcaccacgag catccacacc 480
agcgtgcttt cgggccgcct ttcgtacttc tacggcctgg agggcccggc ggtcacggtc 540
gacacggcgt gttcgtcgtc gctggtcgcg ctgcaccagg cagggcagtc cctgcgtacc 600
ggcgaatgct ccctcgccct ggtcggcggc gtcacggtca tggcgtcacc cgcgggcttc 660
gcggacttct ccgagcaggg tggcctggcg ccggacgggc gctgcaaggc gttcgccgag 720
gcggcggacg gcaccgcctt ctccgagggc tccggggtcc tggtcgtgga acggctctcc 780
gacgccgaac gccacggcca ccgtattctc gcggtcgtac gaggctccgc cgtcaaccag 840
gacggcgcct ccaacggact ctccgcaccc aacgggccct cccaggaacg cgtcatccgc 900
caggccctcg cgaacgcggg cctccagccc tcggacgtgg acgcggtcga ggcgcacggc 960
accggcaccc gcctcggcga ccccatcgag gccaccgcac tcctcgcgac ctacggacaa 1020
caccgtacga ccccgctcct gttgggttcg ctgaagtcca acatcggcca cacccaagcc 1080
gccgcgggcg tcgcgggcat catcaagatg gtcctggcga tgcaccacga caccctgccg 1140
cccaccctcc acgtcgacac accctcctca cacgtcgact ggacgacagg aggtgtcgag 1200
ctcctcaccg atgcccggcc ctggcccacc accacaggcc cgcgccgcgc cggtatctcc 1260
tccttcggag tcagcggcac caacgcccac gtcatcctcg aaagccccac tccggttccc 1320
tcccccggcg ccgaacccgg cgcccgcccc gtacccctgc ccatctcagc ccgcactccc 1380
gaagcactcg acgaacacac catccgcatc cgtgcgttcc tcgacgacaa ccccggcgcg 1440
gaccacgtcg ctgtcgcaca gacgctcgcg cggcgcaccc ctttcgagca ccgcgccgtg 1500
ctgctcggcg acacgctcat caccgcggac ccgaacgcgg gctccggtcc tgtcgtcttc 1560
gtctactccg ggcagagcac gctccacccg cacaccggta ggcaactcgc ggccacgtac 1620
cccgtgttcg ccgacgcgtg gggcgaggtc ctcggtcatc tcgacgccga tcagggtcct 1680
gccacgcact tcgcccacca gatcgcgctc accgcgctcc tgcggtcctg gggcatcgcc 1740
ccgcacgcgg tcatcggtca ctccctcggt gagatcagcg ccgcgtgcgc ggccggtgtc 1800
ctctccctcg gcgacgcgag cgcgctcctc gccgcccgca gccgtctcat ggacgagctc 1860
cccgcgggcg gcgccatggt caccgtgctg acgagcgagg agaacgcgct ccgggcgctg 1920
cggcccgggg tggagatcgc cgcggtgaac ggcccgcact ccgtcgtgct ctccggcgac 1980
gagggccccg tgctcgccgt cgcacagcag ctcggcatcc accaccgcct gccgacccgc 2040
cacgccgggc actccgcgcg catggatccg ctcgtcgcgc ccctgctcga agccgccagc 2100
ggcctgacgt accaccagcc gcgcatcgcc atccctggag atcccaccac cgccgcatac 2160
tgggcgcgtc aagtccgcga ccaggtgcgc ttccaggcac acgccgagcg gtacccgggc 2220
gccacgttcc tggagatcgg gcccaaccag gacctctccc ccgtcgtcga cggcattccc 2280
acccagaccg gaacgcccga cgaggttcaa gcactgcaca ccgcactcgc ccgcctgcac 2340
acccgtggcg gcgtggtcga ctggccgacc gtgctcggcg gtgatcgcgc gcccgtcgcg 2400
ctgcccacgt atccgttcca gcacaaggac tactggctgc gggccaccgc ccaggcggat 2460
gtgaccggcg cgggacagga gcaggtggcg cacccgctgc tcggcgccgc ggtcgcgctg 2520
cccggcaccg gcggaaccgt cctgaccggc cgcgtctcgc tcgcctccca cccgtggctc 2580
ggcgggcacg ccgtcaacgg caccgtgctc ctgcccggcg cggcgttcct cgaactcgcg 2640
gtgcgcgccg gggacgaggc gggctgcgac ctgctccacg agctcgtcgt cgagacaccg 2700
ctgacgctgc ccgcgaccgg ctccgtggcg atctccgtcg aggtcgccga gcccgacgac 2760
acgggacggc gggcggtcac cgtccacgcg cgggccgatg gcgccgtgct gtggacccgg 2820
cacgccaccg ggttcctcgg caaggccgcc gcgacgactg ccgagacggg ggaccctgcg 2880
ccttggccgc ccgccggggc ccggccggtc gatgtcggcg acgtctacga acggttcggg 2940
agtatcgggt acgcatacgg ttccgcgttc cagggactgc gcgccgcatg gcgcgacggc 3000
gacaccgtgc acgccgaggt cgcgcttccc gacgaacagg gcccggacgc agcccggttc 3060
acgctgcacc ccgcgctgct cgacgccgcg ttccaggccg gggcgctgtc cgcgctcgac 3120
gcgcccggcg aggcggccct gctgccgttc tcgttccagg acgtccggat ccacgcggcc 3180
ggggcgacgc gggcgcgggt caccgtcagc cgtgacggcg atcgcagcac cgtgcgcatg 3240
accggcgagg acggacagcc ggtggccgag gtgggctctg tggtgtcgcg cccgtacgcg 3300
ggcggctccg gctccgacga cgagctgctg cgcccggtct ggaccgagct gccgatgccc 3360
gccccgtccg cggccgaccc gcgcgtggag gttctcggcg cggaccccct cgacggcgaa 3420
cccgccgcgg cgacacggga gttgaccgcc cgcgtcctcg acgcgcttca gcaccgcctg 3480
tccgccaccg atgacgtgac cctggtcgta cggatcggca ccggcctggc cgcggccgcc 3540
accgcgggtc tggtccgctc cgcgcaggcc gagaaccccg gccgcatcgt cctcgtcgag 3600
gcgtccccgg acactccggc ggacctgctc accgcgtgcg ccgccctgga cgaaccacag 3660
ttggccgtcc gggacggtgt gctcttcgcg ccgcggctgg tccggatgtc cgaccccgtg 3720
cacggtccgc tgcccctgcc ggacggcgac tggctgctca ctcactccgc gtccggcgtc 3780
ctgcacgacg tcacgctcgc cgtcgacggc acacctcgcc gggcactgga agccggtgag 3840
gtccgcgtcg acgtccgggc cgcgggtctg aacttccgcg acgtgctgat cgcgctcggg 3900
acgtacgacg gagccaccgc actgggcggc gaggccgcgg gcatcgtcgt ggagaccggg 3960
cccggcgtgg ccgatctggc ccccggtgac cgggtgttcg gcctgacccg gggcggcatc 4020
ggcccgacag ccgtcacgga ccggcgctgg ctggcccgga ttcccgacgg gtggagcttc 4080
accacggcgg catccgtccc catcgtgttc gcgaccgcgt ggtacggcct ggtcgacctc 4140
gcggggctgc gcgcgggcga gaaggtcctc gtgcacgcgg ccaccggcgg tgtcggcatg 4200
gccgccacgc agctcgcccg gcacctgggc gccgaggtct atgccaccgc gggcaccggg 4260
aaacagcacg tcctgcgcgc cgccgggctg cccggcacac acatcgccga ctcgcggacg 4320
acagcgttcc ggaccgactt cccgcgcatg gacgtcgtcc tcaactcgct gaccggtgag 4380
ttcatcgacg catcactcga actcctcgac gcggaaggac ggttcgtcga gatgggccgc 4440
gccgagctgc gcgacccgga cacgatcacg cccgcctacc tgccgttcga cctcatggac 4500
gcgggcaccg accgcatcgg cgagatcctg ggcgaactcc tccagctgtt cgacgcgggc 4560
gccctgaccc cgctgccggt ccgcgcctgg gacgtccggc aggcgcgtga cgcgctcggc 4620
gtgatgagcc gcgcccgcca catcggcaag aacgtcctca cgcttccccg gccgctcgac 4680
ccggaaggcg cgatcgtcat caccggaggc tccggcacgc tcgcgggcat cctcgcgcgc 4740
catgtgagcg ggcaacacgt ctacctgctg tcccgcacgg caccgcccga gggaacgccc 4800
ggcatccacc tgccctgcga cgtcggtgac cgccagcaac tggccgcggc cctgcgccgg 4860
atcgaccggc cgatcaccgc cgtggtgcac accgcgggcg cactggacga cggcaccctc 4920
ccgtcgctca cgcccgagcg cttcgacacc gtgctgcgcc ccaaggccga cggagcctgg 4980
cacctgcacg aactcacgaa ggaccaggac ctcgccgcgt tcgtgctcta ctcctcggcc 5040
gccggagtac tcggcaacgc gggacagggc aactacgtcg ccgcgaacgc gttcctcgac 5100
gccctcgccg aacagcgcca ggcggccggg ctgcccgcgc tctccatcgc ctgggggctc 5160
tgggaggaca cgagcgggct gaccgccgag ctcagcgagg cggacaggca gcggatgcgg 5220
cggagcggat tccgcacgat cagcgcgcgc cagggcatgc ggctgtacga ggcggcgagg 5280
cgcaccggaa gtcccgtggt ggtggcggcc gcgctcgacg acgccccgga cgtgccgctg 5340
ctgcgcgggc tgcggcgtac gaccgtccgg cgggccaccg tccgggaacg ctccctctcc 5400
gacgagctcg ccgtgctgcc cgacgacgag cgcgccgacg cgctcctcgc gttcgtcagg 5460
aacagcaccg ccaccgtgct cggccacctg ggcgcggaag acatcccggc gacagcgacg 5520
ttcaaggaac tcggcatcga ctcgctcacc gcggtccagc tgcgcaacgc gctgaccacg 5580
gcgaccggcg tacgcctcaa cgccacggcg gtcttcgact ttccgacgcc gcgcgcgctc 5640
gccgcgagac tcggcgacga gctggccggt acccgcgcgc ccgtcgcggc ccggaccgcg 5700
gccaccgcgg ccgcgcacga cgaaccactg gcgatcgtcg gcatggcctg ccgcctgccg 5760
ggcggggtcg cgtcgccgga agggctgtgg cgtctcgtcg cgtccggcac cgacgccatc 5820
acggagttcc ccgcggaccg cggctgggac gtggacgcgc tctacgaccc cgaccccgac 5880
gcgatcggca agaccttcgt ccggcacggc ggcttcctcg acggcgcgac cggcttcgac 5940
gccgggttct tcgggatcag cccgcgcgag gccctggcca tggacccgca gcaacgggtg 6000
ctcctggaga cgtcctggga ggcgttcgaa agcgcgggca tcaccccgga ctcggcccgg 6060
ggcagcgaca ccggcgtgtt catcggcgcg ttctcctacg ggtacggcac aggggcggac 6120
accaacggct tcggcgcgac aggatcgcag accagcgtgc tctccggccg cctttcctac 6180
ttctacggcc tggaggggcc gtcggtcacg gtcgacaccg cctgctcgtc gtcgctggtc 6240
gccctgcatc aggccggtca gtcgctgcgc tcgggcgaat gctcgctcgc cctggtcggc 6300
ggcgtcacag tgatggcgtc gcccggcgga ttcgtcgagt tctcccggca gcgcgggctc 6360
gcgccggacg ggcgggcgaa ggcgttcggc gcgggcgcgg acggtacgag cttcgccgag 6420
ggcgccggtg ccctggtggt cgagcggctc tccgacgcgg agcgccacgg ccacaccgtc 6480
ctcgccgtcg tgcgcggctc cgcggtcaac tccgacggcg cgtcgaacgg tctgtcggcg 6540
ccgaacggcc cgtcgcagga acgcgtcatc cgccaggcac tcgccaacgc gaaactcacc 6600
cccgccgacg tcgacgcggt cgaggcgcac ggcaccggca cccgcctcgg cgaccccatc 6660
gaggcgcagg cgctgctcgc gacgtacggg caggaccggg cgacgcccct gctgctcggc 6720
tcgctgaagt cgaacatcgg gcacgcccag gccgcgtcag gggtcgccgg gatcatcaag 6780
atggtgcagg ccatccggca cggggagctg ccgccgacgc tgcacgcgga cgagccgtcg 6840
ccgcacgtcg actggacggc cggtgccgtc gagctcctga cgtcggcccg gccgtggccg 6900
gggaccggtc gcccgcgccg cgccgccgtc tcgtcgttcg gggtgagcgg cacgaacgcc 6960
cacatcatcc ttgaggcggg cccggtcaag gcaggtccgg tcgaggcagg cccggtcccc 7020
gcggcgccgc cgtcagcacc gggcgaagac cttccgctgc tggtgtcggc gcggtccccg 7080
gaggcactcg acgagcagat cgggcgcctg cgcacctacc tcgacacccg ccctggcgtc 7140
gaccgggcgg ccgtggcaca gacattggcc cggcgcacgc acttcgccca ccgcgccgtg 7200
ctgctcggtg acaccgtcat caccacttcc ccctcgcacc aggccgacga actcgtcttc 7260
gtctactccg gtcagggcac ccagcatccc gcgatgggcg agcaactcgc cgccgccttc 7320
cccgtgttcg ccgagacctg gcacgacgcg ctccggcggc tcgacgaccc cgacccgcac 7380
gaccccacac ggagccagca cacgctcttc gcccaccagg cggcgctcac cgccctcctg 7440
aggtcctggg acatcacgcc gcacgccgtc atcggccatt cgctcggcga gatcaccgcc 7500
gcgtacgccg ccgggatcct gtcgctcgac gacgcctgca ccctgatcac cacgcgcgcc 7560
cgcctcatgc acacgcttcc gccgcccggc gccatggtca ccgtgctgac cggcgaggag 7620
gaggcccgtc aggccctgcg gccgggcgtg gagatcgccg cagtcaacgg cgcccattcc 7680
gtcgtacttt cgggcgacga ggacgccgtg ctcgatgtcg cacagcggct cggcatccac 7740
caccgcctgc ccgcgccgca cgccggtcac tccgcgcaca tggagcccgt ggccgccgag 7800
ctgctcgcca ccacccgtcg gctccgctac gaccggcccc acaccgccat tccgaacgac 7860
cccaccaccg ccgagtactg ggccgaacag gtccgcaacc ccgtgctgtt ccacgcccac 7920
acccagcagt accccgacgc cgtgttcgtc gagatcggcc ccggccagga cctctcaccg 7980
ctcgtcgacg gcatcgcgct gcagaacggc ccggcgaacg aggcgcacgc gctgcgcacc 8040
gcgctcgccc gcctcttctc gcgcggcgcc acgctcgact ggcccctcgt gctcggcggt 8100
gcttcgcggc acgacccgga cgtcccctcg tacgcgttcc agcagcggcc ctactggatc 8160
gagtcggctc ccccggccac ggccgacgcg ggccaccccg tcctcggcac cggagtcgcc 8220
gtcgccgggt caccgggccg ggtgttcacg ggtcccgtgc cgaccggtgc ggaccgcgcg 8280
gtgttcatcg ccgaactggc cctcgccgcc gccgacgcca ccgactgcgc gacggtcgaa 8340
cagctcgaca tcacctccgt gcccggcggg tccgcccgcg gcagggccat cgcgcagacc 8400
tgggtcgatg aacccgcggc cgacgggcgg cgccggttca ccgtgcactc ccgggtcggc 8460
gacgctccgt ggacgctgca cgccgagggg gttctccgcc ccggcggcgt gccccggccc 8520
gacgccgtcg acgccgcctg gcccccgccg ggcgcggtgc ccgcggacgg tctttccagg 8580
gcgtggcgac gcgcggacca ggtcttcgtc gaggccgaag tcgacagccc cgacggcttc 8640
gtggcacacc ccgacctgct cgacgcggtc ttctccgcgg tcggcgacgg gagccgccag 8700
ccgaccggct ggcgcgacct cgcggtgcac gcgtcggacg ccaccgtgct gcgcgcctgc 8760
ctcacccgcc gcgccggtgg tgtcgtggaa ctcgccgcct tcgacggcgc cggtctgccg 8820
gtgctcaccg cggagtcggt gacgctgggc gaggtcgcgt cggcaggcgg atccgacgag 8880
tcggacggtc tgcttcggct tgagtggttg ccggtggcgg aggcccacta cgacggtgcc 8940
gacagcctgc ccgagggcta caccctcatc accgccacac accccgacga ccccgaagac 9000
gaccccacca acccccacag cacacccaca cgcacccaca cacaaaccac acgcgtcctg 9060
gccgccctcc aacaccacct caccaccacc aaccacaccc tcatcatcca caccaccacc 9120
gaccccccag gcgccgccgt caccggcctc acccgcaccg cacaaaacga acacccaggc 9180
cgcatccacc tcatagaaac ccaccacccc cacaccccac tccccctcac ccaactcacc 9240
accctcaacc aaccccacct acgcctcacc aacaacaccc tccacacccc ccacctcacc 9300
ccactcacct ccaccggcaa ccccaacccc caccacccca caacacccac cccacccctc 9360
aaccccgacc acgccatcct catcaccggc ggatccggca ccctcgccgg aatcctcgcc 9420
cgccacctca accaccccca cacctacctc ctctcccgca ccccaccacc ccccaccaca 9480
cccggcaccc acatcccctg cgacctcacc gaccccaccc aaatcaccca cgccctcaac 9540
cagatacccc aacccctcac cggcatcttc cacaccgccg ccaccctcga cgacaccccc 9600
ctccacaccc tcacccccca acgcctcacc accgtcctcc aacccaaagc cgacgccgcc 9660
tggcacctcc accaccacac ccaaaaccaa cccctcaccc acttcgtcct ctactccagc 9720
gccgccgcca ccctcggcag ccccggccaa gccaactacg ccgccgccaa cgccttcctc 9780
gacgccctcg ccacccaccg ccacacccac aaccaacccg ccaccaccat cgcctggggc 9840
atgtggcaca ccaccaccac actcaccgca cacctcaccg acagcgaccg cgaccgcatc 9900
cggcgcggcg gtttcctgcc gatctcggac gacgagggca tgcgcctcta cgacgcggcc 9960
gtcggctcgg gcgaggacta cgtactggcc gcctcgatgg acccggcgca gccgatgtcg 10020
ggcgacgtac cgccgatcct cagcggtctg cgcagaagcg cgcgccgcac cgcccggacc 10080
gggcagacgt tcgcgcagcg cctcgccgaa ctgcccgacg ccgaccgcga cacggcgttg 10140
agcaccctcg tcatggatgc cacggccgcc gtgctcggcc acgccgacgc ctccgagatc 10200
gggcccacga ccacgttcaa ggacctcggc atcgactcgc tcaccgcgat cgagctgcgc 10260
aaccggctcg cggaggcaac cgggctccgg ctgagcgcca cgatggtgtt cgaccatccg 10320
acaccgcggg tactcgccgc caagctccgc accgacctgt tcggcacggc cgtacctacg 10380
cccacgcgga cgacccgggc ccgtcacgac gagcccctcg cgatcgtcgg catggcctgc 10440
cgcctgcccg gcggcgtgac ctcacccgag gacctgtggc ggctcgtggc gtccggcacg 10500
gatgcgatca ccgagttccc caccgaccgc ggctgggaca tcgaccggat gtttgacccg 10560
gacccggacg cgcccggcaa gacctacgtc cggcacggcg gtttcctctc cgaggcggcc 10620
gggttcgacg ccgcgttctt cggcatcagc ccgcgcgagg catgggccat ggacccgcag 10680
cagcgcgtca tcctcgaaac cgtatgggaa gcgttcgaga acgccggaat cgtgccggac 10740
accctgcgcg gaagcgacac cggcgtgttc atgggcgcgt tctcccacgg gtacggcgcg 10800
ggcgtcgacc tgggcgggtt cggcgccacg gccacccaga acagcgtgct ctccggccgc 10860
ctctcgtact tcttcggcat ggaaggcccg gccgtcacca tcgacacggc gtgctcgtcg 10920
tccatggtcg cgctgcacca ggcggcgcag tccctgcggg acggcgaatg ctcgctggca 10980
ctcgcgggtg gcgtcacggt gatgcccaca ccgctcggct acgtcgagtt ctgccgccag 11040
cgcgggctcg cccccaacgg ccgggccaag gccttcgcgg agggcgccga cggtacgagc 11100
ttctccgaag gcgccggtgt tctcgtcgtc gagaggctct ccgacgccga gcgcaacggt 11160
cacacggtcc tcgcgctcgt ccgctcctcc gccgtcaacc aggacggtgc ctccaacggc 11220
atctccgcgc ccaacggccc gtcgcagcag cgcgtgatcc gccaggcact cgacaaggcc 11280
ggactcactc ccgccgacgt ggacgtggtg gaggcgcacg gcaccggcac acctctgggc 11340
gacccgatcg aggcgcaggc catcatcgcg acgtacgggc aggaccgcga cacaccgctc 11400
tacctcggtt cggtcaagtc gaacatcggc cacacccaga ccaccgccgg tctcgcgggt 11460
gtcatcaaga tggtgatggc gatgcggcac gggttgctcc cgaagacact ccatgtggac 11520
gagccgtcgt cacatgtgga ctggtcggca ggggcggttg agctgctcac ggaggcgagg 11580
ccgtggccgg actcggaccg cccgcgccgg gcaggtgtgt catcgctcgg catcagcggc 11640
acgaatgcgc atgtgatttt ggagggggtt gcggagtcgt cggttcgtag cggggggtcg 11700
tcgggtctgg tgccgttgcc ggtgtcggcg cgtacggagt cgagcttggc gttgcaggtg 11760
gagcgggtcg gcgagtatgt gcggggtggg gcggacctgg gcgcggtggc ggatggtctg 11820
gtgcgtgggc gtgcggtgtt cgaccgtcgg gcggtgttgc tcggggagag cacggtcgcc 11880
ggagtcgctg tggagggggc gcggacggtg ttcgtgttcc cggggcaggg ctcgcagtgg 11940
gtgggcatgg gccgggagtt gatgggcgcc tcggaggtgt tcgcggcgcg gatgcgggag 12000
tgtgcggcgg cgttggagcc gcataccggt tgggatgtgc tggatgtgct gggtgaggcg 12060
gtggtggctg atcgggtgga ggtgttgcag cccgcgtcgt gggcggtggc ggtgagcctg 12120
gccgcactgt ggcaggccca cggcgtggtg ccggatgcgg tgatcgggca ttcgcagggg 12180
gagatcgccg cggcatgtgt ggcgggagcc ttgagtctgg aggacgccgc gcgggtcgtg 12240
gccttgcgca gccagaccat cgctgcgcgg ctggccgggc acggggcgat ggcatcaatc 12300
gccctgcccg ccagcgccgt tgaggtagcg gagggcgtgt ggatcgccgc gcgcaacggt 12360
ccggaatcca ccgtggtcgc gggcgatccg ggcgcggtgg agcgggtgct ggcccggtat 12420
gaggctgcgg gtgtgcgggt gcgccggatc gcggtggatt acgcctcgca caccccgcac 12480
gtggaagcga tcgaggagca actcgccgac gtcttagggg gaatcaccag cagcgcacct 12540
gacatctcct ggtggtcgac ggtggacagc ggctgggtga ccgaaccggt cggtgacgac 12600
tactggtacc gcaacctgcg tcagcccgtc gcgatggaca ccgcgatcag tgagctggac 12660
ggctcgctgt tcatcgagtg cagcgcccac ccggtgctgc tgcccgccct cgaccaggaa 12720
cacaccgtcg cctccctgcg caccgacgac ggcgactggg accggttcct gaccgccctc 12780
gcacaggcct ggacccaggg cgcacccgtc gactggacca ccctgatcga gcccgccccg 12840
caccgcctgt tggacctgcc cacctacccc ttcgaccaca agcggtactg gatagaggcg 12900
gccagcgcaa ccgacctcac cgccctcggt ctcaccgaca ccgcacaccc catgctggcg 12960
gcgaccgccg cgctgcccac gaacgacggc accgtactca ccggccggat ctccctgcgt 13020
acccatccct ggctggccga ccacgccatc caggactcgg tgttgctgcc gggcacagcg 13080
ttcctcgaac tcgtggtgcg ggccggagac gaggtcggct gcgacaccat cgacgaactg 13140
gtcatcgaga ccccgctcgt actgcccgtc accggtgccg tcgacctcac cgtcaccgtc 13200
gaccagcccg acaccaccgg ccaccgcccg gtgagcgtcc acgcacgccc cgaaggaacc 13260
gacacctgga cccgccacgc caccggcaca ctcaccacca gcgccaccga caccaccccc 13320
gccccgagct ccttcccgca atggccgcca accagcgcct ctgccatcga catcacggag 13380
ttctacgccc aactggccgt gctgggctac cggttcggcc ccacgttccg cggactgcgg 13440
gcagcgtggc gtgacggtga caccgtgtac gccgaggtgg cgctgcccga ggaccgtgcc 13500
gccgacgcgg accgcttcgg cgtacacccg gccctgctcg acgccgcgtt gcagagcggc 13560
agtctgctca tgctggcatc ggacggcgag cagggcgtgc aactgccgtt ctcctggcac 13620
ggcgtccggt tccacgcgac cggggcgacc tcactgcggg tgacgatcgt gcccggcccc 13680
gacggcctcc ggctccgcgc cgccgacagc gagaaccacc ccgtcgcgac catcgacgca 13740
ctggtcaccc ggcctcctgc cgacctcgca cccgccgacc ctgtgctgcg ggtcgggtgg 13800
accgcggtgc ccgtacctgc cgaggtcagc ccgtccgacg cggacgtact gacactgcac 13860
agcgacgatg ccgatccggt ccaggaaacc cgggaactca ccactcgcgt gctcgacgcg 13920
ctgctggagg tcgagcggac cctgatcgtc caggtcaccg gcggtcttgc cgcgatggcg 13980
gccgcgggcc tggtccgcac cgctcagagc gagcagcccg gccgtttctt cctcgtcgag 14040
acggaccccg gagaggtctt ggacagcgcg cggtgcgaca cgatcgcggc gctcggcgag 14100
ccccggctgc ggcttcgcga caaccggttc gaggcagccc ggctggtgcg cgccacaccc 14160
gccctgacgc ctccggacac cgggtcgtgg cagctgcggc agtccgccac cggctcgctc 14220
gacgacctcg ccctcgtgcc caccgacgag cccgaccggc cgctcgcagc cggtgaggtg 14280
cggatcgcgg tacgtgcggc gggcctgaac ttccgcgacg tcacggtcgc cctcggcgtg 14340
gtcgccgatg accgcccgct cggcagcgaa gccgccggtg tcgtcctgga gaccggtccc 14400
ggcgtgcacg acctggcgcc gggcgaccgg gtcctgggga tgctcgctgg cgcgttcggg 14460
ccggtcgcga tcactgaccg tcggctgctg ggccgagtgc cggagggttg gacgtttccg 14520
caggcggcgt cggtggtgac ggtgttcgcg accgcctggt acggcctggt cgacctggcc 14580
gagctgcgca ccggcgagaa ggtcctgatc cacgcggcgg ccaccggagt cggcgcggcc 14640
gccctccaga tcgcccgcca cctgggcgcg gacgtgtacg ccaccgccag cacccccaaa 14700
cagcacctgg tggacctggc acccacccac atcgccgact cccgcagcac cgccttcgcc 14760
gacaccttcc ccccggccga cgtcgtcctc aactccctca ccggcgaact cctcgacgcc 14820
tccaccgcac tcctcacacc cggcggccgg ttcatcgaaa tgggcaagac cgacatccgc 14880
caccacgccc aacagccctt cgacctcatg gacgcaggac ccgaccgact ccagcagatc 14940
atcacccaac tcctcgacct gttcgccaac ggcacactgc accccctacc ggtccacgcc 15000
tgggacgtac gacaggcgcg ggaggcgttc ggctggatga gcagcggtcg gcacacgggc 15060
aagctggtac tcacggtccc gcgaccgctc gaccccgagg gcgccgtcat catcaccggc 15120
ggctccggca ccctcgccgg aatcctcgcc cgccacctca accaccccca cacctacctc 15180
ctctcccgca cacccccgcc cgacaccacc cccggcaccc acctgcgctg cgacgtcagc 15240
gaccccaccc aactcgccac cgccctcgcc cagatacccc aacccctcac cggcatcttc 15300
cacaccgccg ccaccctcga cgacgccctc ctcgacaacc tcacacccca acgcatcgac 15360
accgtcctca aacccaaagc cgacgccgcc tggcacctcc accaccaaac ccgccacacc 15420
gacctcaccg cattcgtcct ctactccgcg gtcgccggtg tcatgggcag tcccggccag 15480
ggcaactacg tagcggcgaa cgcgttcctc gacgcactcg ccgaacaccg gcaggcgagg 15540
ggactgcccg cgcagtcgct cgcgtggggc atgtgggcgg acgtcagcgc actcaccgcg 15600
aaactcaccg atgccgaccg cgaacgcatc cggcgcagcg gattcccgcc gttgagcgcg 15660
gcggacggca tgcggctttt cgactcggcg gcgcgtacgc cggagccggt cgtcgtcgcc 15720
acgaccgtcg acgtcacccg gctcgacggc ccggtcgcgc cgctgctccg cggcctggtg 15780
gcccaccggt cagggccggt gcgagcggtc gcccgcaacg ccgacgacga gccgctcgcg 15840
gcacgtctcg ccgggcacac cgccgccgag cagcggcgcg tgatgcagga ggtcgtgctc 15900
cgtcaggcgg ccgcggtgct cgcgtacggc ctgggcgaac aggtcgcggc ggaccggccg 15960
ttccgcgatc tcggcttcga ctcgctgacc gcggtcgacc tgcgcaaccg gctcgcggcc 16020
gagacggggc ttcggctgcc gacgaccgtg gtgttcagcc acccgacggc ggaggcactc 16080
gccacgcacc tgctcgaact gctcgacgct cctgccgccc tgaccgccgg ggcgtccctg 16140
cccgcggtga cggccgcgcc cggcacggcc gcgcgggatc aggacgagcc gatcgcgatc 16200
gtggcgatgg cgtgccgcct gcccggcggc gtgacgtcac cggaggagct gtggcggctc 16260
gtcgagtccg gcaccgacgc gatcaccatg gcgcccggcg accggggctg ggacctcgac 16320
gcgctgtacg acccggaccc ggacgcggtg ggcaaggcgt acaacctgcg gggcggattc 16380
ctggaggggg cggcggagtt cgacgcggcg ttcttcgaca tcagcccgcg ggaatcgctc 16440
ggcatggatc cgcagcagcg cctgctgctc gaaacggcgt gggaggcgat cgagcgcggc 16500
cggatcaacc ccgcgtcgct gcacggccgg gagatcggtg tgtatgtggg tgccgccgcg 16560
cagggctacg gtctcggcgc cgaggacacc gagggcaacg cgatcaccgg cggctccacg 16620
agcctgctgt ccgggcggct cgcgtacgtt ctcgggctcg agggcccgtc cgtcaccgtc 16680
gacacggcgt gctcgtcgtc gctggtcgca ctgcacctcg catgtcaggg gctgcgcctc 16740
ggcgagtgcg agctcgcgct ggccggtggc gtttcggtgc tgagctcacc ggccgcgttc 16800
gtcgagttct cccgccagcg cggtctcgcg gccgacgggc gctgcaagtc gttcggttcg 16860
ggcgcggacg gcacgacgtg ggccgagggc gtgggtgtcc tcgtcctcga acggctctcc 16920
gacgccgagc ggctcggcca caccgtgctc gccgtcgtcc gcggcagcgc cgtcacgtcc 16980
gacggcgcct cgaacgggct caccgcgccg aacgggctcg cgcagcagcg ggtcatccgc 17040
aaggcgctcg ccgcggccgg actgaccgcc gccgacgtgg acctcgtcga gggacacggc 17100
acgggcaccc ggctcggcga ccccgtcgag gcggacgcgc tgctcgcgac gtacgggcag 17160
aaccgccagg agccggtctg gctgggctcg ctgaagtcga acatcgggca tgcgacggcc 17220
gcggccggtg tcgcgggcgt catcaagacg gtgcaggcga tcggcgcggg cacgatgccg 17280
cggacgctgc acgcggacga gccctcgccc gccgtcgact ggaccgccgg gcgggtgtca 17340
ctgctcaccg gcaaccggcc ctggccggac gacgagcgtg cccggcgagc agcagtctcc 17400
gcgttcgggc tcagcgggac gaacgctcac gtcatcctcg aacagcaccg gccggagccc 17460
gtggcgccgc gaccgcctcg cgaggaacct cggccgctgc cctgggtgct gtccgcgcgg 17520
acccctgccg cgctgcgggc gcaggccgcc cggctgcgcg atcacctggc ggccgtgccg 17580
gacgcggacc cgttggacat cggatacgcg ctggccacca gccgcgcccg gttcacacac 17640
cgggccgcgg tagtggccac ttcctctgac gagttccgcg ccgggctcga cagcgtcgcg 17700
gacggcgtcg aagcgcccgg agtcgtcggc ggaaccgctc gggagcggcg cgtcgccttc 17760
ctcttcgacg ggcagggcgc ccagcgcgtc ggcatggggc gcgaactcca cgggcgtttc 17820
cctgtcttcg ccgccgcgtg ggacgaggtg tccgacgcgt tcggcaagca cctggagcac 17880
tcccccacgg acgtcttcca cggcgagcac ggtgatctcg cccatgacac cttgtacgcc 17940
caggtcggcc tgttcacgct cgaagtggcg ctgctgcggc tcctcgagca ctggggtgtg 18000
cgtcctgacg tgctcgtcgg gcactccgtc ggcgaggtca ccgcggcgta cgcggcgggc 18060
gtgctcacgc tggcggacgc gacggcgttg atcgtggccc gtgggcgggc gttgcgggcg 18120
ctgccgccgg gagcgatgac cgcggtcgac ggaagcccgg cggaggtcgg cgcgttcacc 18180
ggtctggaca tcgccgcggt caacggcccg tccgccgtgg tgctcacggg ttcaccggac 18240
gacgtgaccg cgttcgaacg ggagtgggcg gcggccgggc ggcgcgcgaa acggctcgac 18300
gtcgggcacg cgttccactc ccggcacgtc gacggcgcgc tcgacgactt ccgtacggtc 18360
ctcgaatcgc tctcgttcgg cgcggcccgg ctgccggtgg tgtccacgac gacgggccgg 18420
gacgccgcgg gcgacctcgc gacgccggag cactggctgc gtcatgcgcg ccgtcccgtg 18480
ctgttcgcgg acgccgtccg ggagctcgcc gacctcggcg tgaacatgtt cgtggccgtc 18540
ggtccttccg gggcactcgc gtcggccgcg tcggagaaca ccggcgggag cgccgggacg 18600
taccacgcgg tgctgcgcgc ccggaccggc gaggagaacg cggcgctgac cgccgtcgcc 18660
gaactgcacg cccacggcgc cccggtggac ctcgccgcgg ttctggcggg cggacgcccg 18720
gtggaccttc ccgtgtaccc gttccagcac cgctcctact ggctggcccc tgccgtggga 18780
ggtggttcgc cgaccgccgt gccggacacc gggcggccgg cggagcccga ccctgacgac 18840
ctcaccgtcg ccgagatcgt ccggcggcgt gccgcggcac tgctcggcat cgccgacccc 18900
ggcgacgtcg acgcggacac gaccttcttc gcgctcgggt tcgactccct cgccgtccag 18960
cggctgcgca atcagctcac ggcggcgacc ggcctcgacc tgcccacggc cgtcctgttc 19020
gaccacgaca ccccgtccgc cctcaccgct tatctggagg agcagctcgg cgacggcgcg 19080
gacgacgacg cacccaccgt gctcgcgctc ctggcggaga tggagtcgct cgacgccgcg 19140
gacatcgcgg cgacaccggc cccggagcgt gcggccatcg ccgatctgct cgacaagctc 19200
tcccgtacct ggaaggacca ccgatga 19227
<210> 85
<211> 388
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 85
Met Ser Pro Asp Thr His Asp Glu Thr Thr Ala Thr Ser Arg Cys Pro
1 5 10 15
Phe Ala Ile Gln Asp Ala His Arg Ala Ile Leu Glu Ser Gly Thr Val
20 25 30
Gly Ser Phe Asp Leu Phe Gly Ile Lys His Trp Leu Val Ala Ala Ala
35 40 45
Glu Asp Val Lys Leu Val Thr Asn Asp Pro Arg Phe Ser Ser Ala Ala
50 55 60
Pro Ser Glu Met Leu Pro Asp Arg Arg Pro Gly Trp Phe Ser Gly Met
65 70 75 80
Asp Leu Pro Glu His Ser Arg Tyr Arg Gln Lys Ile Ala Gly Asp Phe
85 90 95
Thr Leu Arg Ala Ala Arg Lys Gln Glu Asp Phe Val Val Glu Ala Ala
100 105 110
Asp Ser Cys Leu Asp Asp Ile Glu Val Ala Gly Pro Gly Thr Asp Leu
115 120 125
Ile Pro Gly Tyr Ala Lys Arg Leu Pro Ser Leu Val Ile Asn Ala Leu
130 135 140
Tyr Gly Leu Thr Leu Glu Glu Gly Glu Val Leu Glu Ala Arg Met Arg
145 150 155 160
Gly Ile Thr Gly Ser Val Asp Leu Asp Ser Val Lys Thr Leu Thr Asp
165 170 175
Asp Phe Phe Ala His Ala Leu Glu Leu Val Arg Ala Lys Arg Asp Glu
180 185 190
Gln Gly Asp Asp Leu Leu His Arg Leu Ala Ser Thr Ser Asp Gly Glu
195 200 205
Ile Ser Leu Ser Asp Asp Glu Ala Thr Gly Val Phe Ala Thr Leu Leu
210 215 220
Phe Ala Gly His Asp Ser Val Gln Gln Met Val Gly Tyr Ser Leu Tyr
225 230 235 240
Ala Leu Leu Ser His Pro Glu Gln Gln Ala Ala Leu Arg Ala Arg Pro
245 250 255
Glu Leu Ile Asp Asn Ala Val Glu Glu Met Leu Arg Phe Leu Pro Val
260 265 270
Asn Gln Met Gly Val Pro Arg Val Cys Val Gly Asp Ile Asp Leu Gln
275 280 285
Gly Val Arg Ile Ser Ala Gly Asp Asn Val Ile Pro Leu Tyr Ser Thr
290 295 300
Ala Asn Arg Asp Ala Ala Val Phe Pro Asp Pro Asp Ala Phe Asp Val
305 310 315 320
Thr Arg Pro Pro Glu Gly Asn Phe Ala Phe Gly His Gly Ile His Lys
325 330 335
Cys Pro Gly Gln His Val Ala Arg Leu Leu Ile Lys Val Ala Cys Leu
340 345 350
Arg Leu Phe Glu Arg Phe Pro Asp Ile Arg Leu Thr Gly Asp Val Pro
355 360 365
Met Asn Glu Gly Leu Gly Leu Phe Ser Pro Ala Glu Leu Arg Val Thr
370 375 380
Trp Gly Thr Glu
385
<210> 86
<211> 1167
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 86
atgagccccg acacgcacga cgagacgacg gccaccagcc ggtgcccgtt cgcgatccag 60
gacgcccacc gggcgatcct ggagagcggc acggtcggct cgttcgatct gttcggcatc 120
aagcactggc tggtcgccgc cgccgaggac gtcaagctgg tcaccaacga cccgcggttc 180
agctcggccg ctccgtccga gatgctgccc gaccggcgtc ccggttggtt ctccggcatg 240
gacctgccgg agcacagtcg ctaccggcag aagatcgccg gggacttcac gctgcgcgcc 300
gcgcgcaagc aggaggactt cgtcgtcgag gccgcggact cctgtctgga cgacatcgaa 360
gtcgccggtc ccggcaccga cctgatcccc gggtacgcga agcggctccc ctccctcgtc 420
atcaacgcgt tgtacgggct cacccttgag gagggcgagg tactcgaggc gcgcatgcgc 480
ggcatcacgg gctcggtcga cctggacagc gtcaagacgc tgaccgacga cttcttcgcc 540
cacgcgctgg agctggtccg cgccaagcgt gacgagcagg gcgacgacct gctgcacagg 600
ctcgcctcga cctcggacgg tgagatctcg ctgagcgacg acgaggcgac gggcgtgttc 660
gcgacgctgc tgttcgccgg gcacgactcg gtgcagcaga tggtcggtta cagcctctac 720
gcgctgctca gccaccccga gcagcaggcg gcgctgcgcg cgcgaccgga gctgatcgac 780
aacgcggtcg aggagatgct gcgcttcctt ccggtcaacc aaatgggggt gccgcgcgtc 840
tgcgtcgggg acatcgacct acagggtgtg cggatcagtg cgggcgacaa cgtgatcccg 900
ctctattcga cggcgaaccg cgacgcggcg gtgttcccgg accccgatgc cttcgacgtg 960
acgcgtccgc cggaggggaa cttcgcgttc ggccacggca tccacaagtg tccgggccag 1020
cacgtcgccc ggctgctcat caaggtcgcc tgcctgcggt tgttcgagcg gttcccggac 1080
atccgcctca ccggtgacgt gccgatgaac gagggcctcg ggctcttcag cccggccgag 1140
ctgcgggtca cctggggtac cgagtga 1167
<210> 87
<211> 212
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 87
Val Val Phe Asp Ile Gly Ala Asn Ile Gly Met Phe Thr Leu Phe Ala
1 5 10 15
His Leu Glu Arg Pro Gly Val Thr Val His Ala Phe Glu Pro Ala Pro
20 25 30
Val Pro Phe Ala Ala Leu Arg Ala Asn Ala Ala Gln Tyr Gly Ile Ser
35 40 45
Gly Arg Val Asp Gln Cys Ala Val Ser Asp Glu Thr Gly Val Arg Lys
50 55 60
Met Thr Phe Tyr Pro Asp Ala Thr Leu Met Ser Gly Phe His Pro Asp
65 70 75 80
Ala Ala Ala Arg Lys Glu Leu Leu Arg Thr Leu Gly Leu Asn Gly Gly
85 90 95
Tyr Thr Ala Glu Asp Val Asp Gly Met Leu Ala Gln Leu Pro Asp Ser
100 105 110
Gly Glu Glu Ile Glu Thr Ala Val Val Arg Leu Ser Asp Val Ile Ala
115 120 125
Glu Arg Arg Ile Ala Thr Ile Gly Leu Leu Lys Val Asp Val Glu Arg
130 135 140
Ser Glu Arg Gln Val Leu Ala Gly Val Asp Glu Ala Asp Trp Pro Arg
145 150 155 160
Ile Arg Gln Val Val Ala Glu Val His Asp Val Glu Gly Ala Leu Asp
165 170 175
Glu Val Val Ala Leu Leu Arg Gly His Gly Phe Thr Val Val Ala Glu
180 185 190
Gln Asp Pro Leu Phe Val Gly Thr Asp Ile His Gln Val Ala Ala Arg
195 200 205
Arg Gly Thr His
210
<210> 88
<211> 639
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 88
gtggtgttcg acatcggcgc gaacatcggc atgttcacgc tcttcgctca tctcgagcgt 60
cccggcgtga ccgtgcacgc gttcgagccc gcgccggtgc cgttcgccgc gctgcgggcg 120
aacgcggcac agtacggcat ctcgggccgg gtggaccagt gcgcggtctc cgacgagacc 180
ggcgtgcgca agatgacgtt ctaccccgac gccacgctga tgtccggctt ccacccggac 240
gccgcggccc gtaaggagct gttgcgcact cttggtctca acggcggata caccgccgag 300
gacgtcgacg gcatgctggc ccaactgccc gattcgggcg aggagatcga gaccgccgtt 360
gtccgcctct ccgacgtcat cgccgagcgc cgcatcgcga cgatcggcct cctgaaggtc 420
gatgtggaga ggagtgaacg gcaggtcctc gccggtgtcg acgaggccga ctggccccgc 480
atccgccagg tcgtcgcgga ggtccacgac gtggagggcg cgctcgacga ggtcgtcgca 540
ctgctgcgcg gccatggctt caccgtcgtc gccgagcagg atccgctgtt cgtcggcacg 600
gacatccacc aggtcgccgc gcggcgtggg acccactga 639
<210> 89
<211> 934
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 89
Met Ala Pro Thr Asp Leu Glu Asp Gly Arg Glu Val Val Pro Glu Val
1 5 10 15
Arg Ala Ala Pro Asp Glu Leu Ile Ala Arg Asp Asp Glu Leu Ser Arg
20 25 30
Leu Gln Arg Ala Leu Thr Arg Ala Gly Ser Gly Arg Gly Gly Val Val
35 40 45
Ala Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr Ala Leu Leu Asp Ala
50 55 60
Gly Ala Ala Lys Ser Gly Phe Val Ala Leu Arg Ala Val Cys Ser Trp
65 70 75 80
Glu Glu Arg Thr Leu Pro Tyr Gly Met Leu Gly Gln Leu Phe Asp His
85 90 95
Pro Glu Leu Ala Ala Gln Ala Pro Asp Leu Ala His Phe Thr Ala Ser
100 105 110
Cys Glu Ser Pro Gln Ala Gly Thr Asp Asn Arg Leu Arg Ala Glu Phe
115 120 125
Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Trp Pro Val Leu Ile Gly
130 135 140
Ile Asp Asp Val His His Ala Asp Ala Glu Ser Leu Arg Cys Leu Leu
145 150 155 160
His Leu Ala Arg Arg Ile Gly Pro Ala Arg Ile Ala Val Val Leu Thr
165 170 175
Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg Phe Gln Ala Glu Leu
180 185 190
Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu Arg Pro Leu Thr Glu
195 200 205
Ala Gln Thr Gly Glu Leu Val Arg Arg His Leu Gly Ala Glu Thr His
210 215 220
Glu Asp Val Ser Ala Asp Thr Phe Arg Ala Thr Gly Gly Asn Leu Leu
225 230 235 240
Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu Ala Arg Thr Ala Gly
245 250 255
Arg Pro Gly Val Val Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Ser
260 265 270
Ser Leu Tyr Arg Cys Gly Pro Ser Ala Leu Arg Val Ala Arg Ala Ser
275 280 285
Ala Val Leu Gly Ala Ser Ala Glu Ala Val Leu Val Gln Arg Met Thr
290 295 300
Gly Leu Asn Lys Asp Ala Val Glu Gln Val Tyr Glu Gln Leu Asn Glu
305 310 315 320
Gly Arg Leu Leu Gln Gly Glu Arg Phe Pro His Pro Ala Ala Arg Ser
325 330 335
Ile Val Leu Asp Asp Leu Ser Ala Leu Glu Arg Arg Asn Leu His Glu
340 345 350
Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val Ala Gly Asn Val Leu
355 360 365
Ala Arg His Gln Ile Gly Ala Gly Arg Val His Gly Glu Glu Ala Val
370 375 380
Glu Leu Phe Thr Gly Ala Ala Arg Glu His His Leu Arg Gly Glu Leu
385 390 395 400
Asp Asp Ala Ala Gly Tyr Leu Glu Leu Ala His Arg Ala Ser Asp Asp
405 410 415
Pro Val Thr Arg Ala Ala Leu Arg Val Gly Ala Ala Ala Ile Glu Arg
420 425 430
Leu Cys Asn Pro Val Arg Ala Gly Arg His Leu Pro Glu Leu Leu Thr
435 440 445
Ala Ser Arg Ala Gly Leu Leu Ser Ser Glu His Ala Val Ser Leu Ala
450 455 460
Asp Trp Leu Ala Met Gly Gly Arg Pro Gly Glu Ala Ala Glu Val Leu
465 470 475 480
Ala Thr Gln Arg Pro Ala Ala Asp Ser Glu Gln His Arg Ala Leu Leu
485 490 495
Arg Ser Gly Glu Leu Ser Leu Ala Leu Val His Pro Gly Ala Trp Asp
500 505 510
Pro Leu Arg Arg Thr Asp Arg Phe Ala Ala Gly Gly Leu Gly Ser Leu
515 520 525
Pro Gly Pro Ala Arg His Arg Ala Val Ala Asp Gln Ala Val Ile Ala
530 535 540
Ala Leu Arg Gly Arg Leu Asp Arg Ala Asp Ala Asn Ala Glu Ser Val
545 550 555 560
Leu Gln His Thr Asp Ala Thr Ala Asp Arg Thr Thr Ala Ile Met Ala
565 570 575
Leu Leu Ala Leu Leu Tyr Ala Glu Asn Thr Asp Ala Val Gln Phe Trp
580 585 590
Val Asp Lys Leu Ala Gly Asp Glu Gly Thr Arg Thr Pro Ala Asp Glu
595 600 605
Ala Val His Ala Gly Phe Asn Ala Glu Ile Ala Leu Arg Arg Gly Asp
610 615 620
Leu Met Arg Ala Val Glu Tyr Gly Glu Ala Ala Leu Gly His Arg His
625 630 635 640
Leu Pro Thr Trp Gly Met Ala Ala Ala Leu Pro Leu Ser Ser Thr Val
645 650 655
Val Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg Ala Glu Arg Trp Leu
660 665 670
Ala Glu Pro Leu Pro Gln Gln Thr Pro Glu Ser Leu Phe Gly Leu His
675 680 685
Leu Leu Trp Ala Arg Gly Gln His His Leu Ala Thr Gly Arg His Gly
690 695 700
Ala Ala Tyr Thr Ala Phe Arg Glu Cys Gly Glu Arg Met Arg Arg Trp
705 710 715 720
Ala Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala Glu
725 730 735
Ser Leu Leu Leu Leu Gly Arg Asp Arg Ala Glu Gly Leu Arg Leu Val
740 745 750
Ser Glu Gln Leu Ser Arg Pro Met Arg Pro Arg Ala Arg Val Gln Thr
755 760 765
Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Pro Gln Arg Ile Asp Leu
770 775 780
Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys Asn Asp Gln Tyr Glu
785 790 795 800
Leu Ala Asn Val Leu Ser Asp Leu Ala Glu Ala Ser Ser Met Val Arg
805 810 815
Gln His Ser Arg Ala Arg Gly Leu Leu Arg Arg Ala Arg His Leu Ala
820 825 830
Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Ala Glu Pro
835 840 845
Ser Asp Ile Gly Gly Ala Trp Asp Ala Thr Leu Gly Gln Arg Ile Ala
850 855 860
Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala Leu Ala Ala Val Gly
865 870 875 880
Arg Thr Asn Arg Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr
885 890 895
Val Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu Ala Val Lys Gly
900 905 910
Arg Gln Gln Leu Pro Lys Glu Leu Ala Asp Val Gly Glu Pro Ala Asp
915 920 925
Arg Asp Arg Arg Cys Gly
930
<210> 90
<211> 2805
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 90
atggcgccga ccgatttaga agatggccgc gaggtggttc ctgaagtgcg agcagccccc 60
gacgaactga tcgcccgcga tgacgagctg agccgcctcc aacgggcact caccagggcg 120
gggagcggaa ggggcggcgt cgtcgccatc accgggccca tcgccagcgg aaagacggcg 180
ctgctcgacg ccggagcggc caagtccggc ttcgtcgcac tccgtgcggt gtgctcctgg 240
gaagagcgca ctctgccgta cgggatgctg ggccagctct tcgaccatcc cgaactggcc 300
gcccaggcgc cggaccttgc ccacttcacg gcttcgtgcg agagccctca ggccggtacc 360
gacaaccgcc tgcgggccga gttcacccgc accctgctgg cgctcgccgc ggactggccc 420
gtcctgatcg gcatcgacga cgtgcaccac gccgacgcgg aatcactgcg ctgtctgctc 480
cacctcgccc gccgcatcgg cccggcccgc atcgcggtcg tactgaccga gctgcgcaga 540
ccgacgcccg ccgactcccg cttccaggcg gaactgctga gcctgcgctc ctaccaggag 600
atcgcgctca gaccgctcac cgaggcgcag accggcgaac tcgtacgtcg gcacctcggc 660
gcggagaccc acgaggacgt ctccgccgat acgttccggg cgaccggcgg gaacctgctc 720
ctcgggcacg gtttgatcaa tgacatccgg gaggcgcgga cagcgggacg gccgggggtc 780
gtcgcggggc gggcgtaccg gctcgcgtac ctcagctcgc tctaccgctg cggcccgagc 840
gcgctgcgtg tcgcccgggc gtccgccgtg ctcggcgcga gcgccgaagc cgtgctcgtc 900
cagcggatga ccggactgaa caaggacgcg gtcgaacagg tctatgagca gctgaacgag 960
ggacggctgc tgcagggcga gcggtttccg cacccggcgg cccgctccat cgtccttgac 1020
gacctgtcgg ccctggaacg cagaaacctg cacgagtcgg cgctggagct gctgcgggac 1080
cacggcgtgg ccggcaacgt gctcgcccgc caccagatcg gcgccggccg ggtgcacggc 1140
gaggaggccg tcgagctgtt caccggggcc gcacgggagc accacctgcg cggtgaactg 1200
gacgacgcgg ccggatacct ggaactcgcc caccgtgcct ccgacgaccc cgtcacgcgc 1260
gccgcactac gcgtcggcgc cgccgcgatc gagcgcctct gcaatccggt acgggcaggc 1320
cggcatctgc ccgagctgct caccgcgtcg cgcgcgggac tgctctccag cgagcacgcc 1380
gtgtcgctcg ccgactggct ggcgatgggc gggcgcccgg gcgaggcggc cgaggtcctc 1440
gcgacgcagc gtcccgcggc cgacagcgag cagcaccgcg cactcctgcg cagcggcgag 1500
ttgtccctcg cgctggtcca ccccggcgcg tgggatccgt tgcgccggac cgatcggttc 1560
gccgcgggcg ggctcggctc gcttcccgga cccgcccggc accgcgcggt cgccgaccaa 1620
gccgtcatcg cggcgctgcg tggacgtctc gaccgggcgg acgccaacgc ggagagcgtt 1680
ctccagcaca ccgacgccac ggcggaccgg accacggcca tcatggcgtt gctggccctg 1740
ctctacgcgg agaacaccga tgctgtccag ttctgggtcg acaaactggc cggtgacgag 1800
ggcaccagga caccggccga cgaggcggtc cacgcggggt tcaacgccga gatcgcgctg 1860
cgccgcggcg acttgatgag agccgtcgag tacggcgagg cagcgctcgg ccaccggcac 1920
ctgcccacct ggggaatggc cgccgctctg ccgctgagca gcaccgtggt tgccgcgatc 1980
cggctcggcg acctcgacag ggccgagcgg tggctcgccg agccgctgcc gcagcagacg 2040
ccggagagcc tcttcgggct gcacctgctc tgggcccgcg ggcagcacca cctcgcgacc 2100
gggcggcacg gggcggcgta cacggcgttc agggaatgcg gcgagcggat gcggcggtgg 2160
gccgtcgacg tgccgggcct ggccctgtgg cgggtcgacg ccgccgaatc gctgctgctg 2220
ctcggccgtg accgtgccga aggactgcgg ctcgtctccg agcagctgtc ccggccgatg 2280
cgccctcgcg cgcgcgtgca gacgttacgg gtacaggcgg cctacagtcc gccgccccaa 2340
cggatcgacc tgctcgaaga ggccgccgac ctgctggtca cctgcaacga ccagtacgaa 2400
ctggcaaacg tactcagcga cttggcagag gcctccagca tggtccggca gcacagcagg 2460
gcgcggggtc tgctccgccg ggcacggcac ctcgccaccc agtgcggcgc cgtgccgctc 2520
ctgcggcggc tcggcgcgga accctcggac atcggcggag cctgggacgc gacgctggga 2580
cagcggatcg cgtcactgac ggagtcggag cggcgggtgg ccgcgctcgc cgcggtcggg 2640
cgtacgaaca gggagatcgc cgagcagctg ttcgtcacgg ccagcacggt ggaacagcac 2700
ctcacgaacg tgttccgcaa actggcggtg aagggccgcc agcagcttcc gaaggaactg 2760
gccgacgtcg gcgagccggc ggaccgcgac cgccggtgcg ggtag 2805
<210> 91
<211> 255
<212> PRT
<213> Streptomyces kanamyceticus KCTC9225
<400> 91
Met Lys Glu Asp Leu Trp Leu Arg Gln Phe Phe Pro Thr Pro Asp Ala
1 5 10 15
Ala Val Arg Val Val Leu Leu Pro His Ser Gly Gly Ser Ala Thr Phe
20 25 30
Tyr Leu Pro Leu Ala Arg Ala Leu Ala Pro Val Ala Asp Val Tyr Ala
35 40 45
Val Gln Tyr Pro Gly Arg Gln Asp Arg Arg Asp Glu Glu Pro Leu Arg
50 55 60
Asp Leu Arg Ser Leu Ala Gly Leu Val Ala Gln Ala Leu Glu Pro Gly
65 70 75 80
Leu Asp Arg Pro Leu Val Leu Phe Gly His Ser Met Gly Ala Thr Leu
85 90 95
Ala Phe Glu Leu Ala Arg Arg Val Pro Val Ala His Leu Ile Val Ser
100 105 110
Gly Gly Arg Ala Pro Ser Arg Ala Leu Thr Asp Thr Val His Leu Ala
115 120 125
Ser Asp Asp Glu Leu Leu Ala Ala Val Val Gly Leu Gly Gly Thr Ser
130 135 140
Ala Asp Val Leu Ala Asp Asp Glu Leu Arg Ala Leu Val Leu Pro Pro
145 150 155 160
Leu Arg Ala Asp Tyr Tyr Ala Ala Glu Thr Tyr Arg Trp Glu Pro Ala
165 170 175
Pro Pro Leu Asp Thr Pro Ile Thr Val Cys Ile Gly Asp Ser Asp Pro
180 185 190
Lys Thr Thr Val Glu Gln Ala Arg Ala Trp Ala Gly His Thr Thr Ala
195 200 205
Pro Thr Ala Val Glu Val Phe Pro Gly Gly His Phe Tyr Leu Val Glu
210 215 220
His Gln Glu Arg Val Ala Glu Thr Val Ala Arg Gly Val Arg Leu Ala
225 230 235 240
Ala Pro Arg Gly Gly Ala Thr Glu Glu Ala Asp His Ala Ile Arg
245 250 255
<210> 92
<211> 768
<212> DNA
<213> Streptomyces kanamyceticus KCTC9225
<400> 92
atgaaagagg atctctggtt acgccagttc ttcccgacgc ctgacgctgc cgtacgggtg 60
gtgctgttgc cccactccgg agggtcggcg accttctatc tgccgctcgc ccgcgcgctc 120
gccccggtgg cggacgtgta tgccgtgcag tatcccggcc gtcaggaccg tcgggacgag 180
gagccgctgc gggacctgcg ttcccttgcc gggctcgtgg cgcaggcgct ggagccgggt 240
ctcgaccggc cgttggtgtt gttcggtcac agcatgggtg cgacgctcgc gttcgagctg 300
gcgcggcggg tcccggtggc gcacctgatc gtgtcgggcg ggcgtgcgcc gtcgcgtgcg 360
ctcaccgaca ccgtccatct ggcgtcggac gacgagttgc tggcggcggt ggtcggactc 420
ggcggcacga gcgccgacgt actggcggac gacgaactgc gtgcgctggt cctgccgccg 480
ctgcgcgcgg actactacgc ggcggagacg taccggtggg agcccgcgcc gccgctggac 540
acgccgatca cggtgtgcat cggcgacagc gatccgaaga cgacggtgga gcaggcccgt 600
gcctgggccg gtcacaccac cgcgccgacg gccgtggagg tcttcccggg cgggcacttc 660
tacctcgtcg agcaccagga gcgggtggcc gagacggtgg cgcgaggcgt acggctcgcg 720
gcgccgcggg gcggagccac ggaagaggca gatcatgcca tccggtaa 768
<210> 93
<211> 98833
<212> DNA
<213> Streptomyces sp. ATCC55098
<220>
<221> misc_feature
<222> (14)..(14)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (20)..(20)
<223> n is a, c, g, or t
<400> 93
ccagtagacg gcangccagn ctgcatgcct gcaggtcgcc cacgcactcg ccacccgcac 60
ccaccacgaa gaacgcgccg tcatcaccca cggcaccccc gaagaacgcc accaggccct 120
cacgcacctc gctcgcggca ccacccaccc ccacaccatc accggacaca ccaaccccga 180
caaccacctc gccatgctct tctccggcca aggctcccaa caccacaaca tgggccgcga 240
actctacgac acctaccccg ccttcgccga cgccctcgac accacctgca ccgcactcga 300
cccccacctc gacacccccc tccacaccat cctctacgga cccaaccccc acctcatcca 360
ccaaaccatc tacacccaac ccgccctctt cgccttccaa accgccctct accacctcct 420
ccaacactgg aacatccacc cccacaccct cgccggacac tccatcggcg aaatcaccgc 480
cgcccacacc gccggcatcc tcaccctcac cgacgccgcc accctcatca ccacccgcgg 540
ccgcctcatg caaaacctcc ccaccaacgg caccatggcc gccatcaaca ccacccaaga 600
cgccatacgc cccctcctcg aagaacacca caacaccatc ggcatcgccg ccatcaacgg 660
acccgaatcc ctcgtcctct ccggagaaaa gaacacacta cgaaccatca ccgacaccct 720
caaaaaccaa ggcatccgcg tcaaacacct caacgtctcc cacgccttcc actcccccct 780
catggacccc atcctcaacg aactccacac cacagcaacc caactcacct accacccacc 840
caccatcccc atcatctcca ccgtcaccgg ccaacccatc accccccaca ccatgaccga 900
cccccactac tggaccaccc acgcccgcca caccgtccaa ctccaccaag ccacccaaca 960
cctcacccac cacaccaccc tcgaaatcgg acccgcaggc accctcaccc cccacctccc 1020
cacacccgca caccccaccc accgcaccaa ccaacccgaa ccccacaccc tcaccaccac 1080
cctcgcccac ctccacaccc acggacacac ccccaactgg accacctact acaaccaccc 1140
cacaaaccac cacacccccc tccccacata ccccttccaa caccacacct actggctcaa 1200
ccagcccgac acaccgcgtg aaagctcacc ggcggagctg gggttggaga ccgcgcacca 1260
tcctctgctc tccacggtcg tcacggaccc tgaatcgggc ggggcgatct tcacgggccg 1320
gatctctctc gccagtcatc cgtggctcgc cgatcacgtg gtgggcgaga cggtcctgtt 1380
ccccggaacg gccttcgtgg aactcgccct ccacaccggg gaggtgtgcg gctacgacgt 1440
cctcgacgat ctcacgctgg aggcaccgct cccgatcccc gagcagggga tggtcgacat 1500
ccgcgtcacc gtcgcacccg ccgacgcgga aggaaggtgc ggcgtctacg tgcacgcgcg 1560
tcggtccgac ggttgggcac gtcacgcgag cgcgaccttg gtcaaggacg gggcgggcac 1620
agcctccctc aggcacggct ctcagccgtc ggacagcatg gatacgtggc cgcccacgga 1680
tgccgtgccg gtcgagatgg acggtgtcta cgacgcgttg ggcgacaggg ggctgcacta 1740
cggtacggcc tttcaggggc ttcgcgcggt ctggcggtcc gagcgcgaag tgttcgcgga 1800
ggtttccctc ccggaagcgg ccggtgacgt cgcggatcag tacgtcgtcc atccggcgct 1860
gttggattcc gtactgcacg ccgtggggct cggggacttc gtcgacgcga gcacggaggg 1920
gccgagtctg ccgttcgcct ggcgtcgtgt gcggatcgac gtggcgggag cggacactct 1980
gcgtgtccga ctgtcggccg tcggcaagga cacggtggcg ttgcggctgt tcgacgaggg 2040
cggggcgccg atgggcggcg ttgaggagct gacgctcagg tctctccccg tcggcggcgc 2100
ggcggactcc gacgacgggc cccggccgtc cttcctacgt gtcgactggc agcgggtgcc 2160
ggggcacctc ggcacggtgg cgcccggctg gtgggcgttg ttggacgttt ccgaacggcg 2220
gccgcaccgg actcccgagt cgctccgtgg cagcggcgtt catgtggacg cctaccgcga 2280
gttctcggag ctcgcgaccg tggtagccga cacgggctcg gcgccggaca ccgtcatgat 2340
gcggctgcaa gcgccaccgg gcgccaccac cgtgcccgaa gcggcatcgg acctcgccct 2400
ggacactctt ggtctgttgc aggactggct gcgtgatgac cgtttccgcg actcgcacct 2460
ggtggtgatc acctgtgccg ccgtggcgac ggacggggcg tccgagatcg accccgtgat 2520
ggccgccgtc tggggcatgg tgcgtgccgc tcaatcggag catccggggc gggtgagcat 2580
cgtcgacctc gaagccgaca ccgctgacgt gccgtggcgc tcgctcagcg aggtgctcac 2640
gtcgggtgag ccgcaagccg ctgtacgcgc cggatccgtc cgtgtcccga ggctggtgtc 2700
ccaccctgcc cacccggcgg ccgagccgtc cgggctcgac ccgcgaggga ccgtgctcgt 2760
gaccggcgcc gctggggcgc tcggcagcgc ggtggcacgt catctggtct ccgcccacgg 2820
ggtcagccac ttgctcctcg ccggccgccg tggcgagcgg gcccccgaaa tggtggccct 2880
gcgggaggaa ctggaacacc tggccggtgc tgaggcgcgt atcacggtcg cttcctgtga 2940
tctggccgag cgctccgacg tggtgaggct cctcggttcc ctacccccgg accagcggct 3000
gacagccgtg gtgcacaccg ccggtgtact cgacgacggt gtcctggacc tgctgtctcc 3060
cgagcgggtc acccgggtgc tgcgccccaa ggtggacgcc tcatggcatc tgcacgagtt 3120
gacgcgcgat ctcgacctct ccgccttcgt tctcttctcg tcggcggccg gcgtactcgg 3180
ctccgcgggt caggccaact acgcggcggg caataccttc ttggacgcgc tggccgcgca 3240
ccgcagggtt tccggtctcc caggggtgtc cttggcctgg ggcccttggg acaccgagag 3300
cggtatggcg ggggaactcg gcgcggagga caggaaccgg ctggagcggg gcgggctgct 3360
gccgctctcc gtcgaagagg gcctggcgct cttcgacgcg gccctcgccg aggagctgga 3420
gcgtcgtgcc gagccgctgc tcgtgtccgc ccgcgtcgac acggatgcgt tgcgtgccct 3480
gtcctcgcgt gcgcccctgc cttctctgtg gcatgccctc gtccgtccga gggtcaggcc 3540
gcgtcgctcc tcggcggcca acggcagctc cgagtccgac ctcaggaccc ggtggtcaag 3600
tctgggctcc gacgatcggg agaaggctct tctcgatctg gtgcgcgggg aggtcgcgtc 3660
ggtactcggc catgtctcgc tcgaagctgt cggtggcgac cgggcgttca cggaactcgg 3720
attcgactcg ctgaccgcgg tcgagctgag gaacagactt gagcgggcca ccggcctgaa 3780
gttgtccgcc acggtggtct tcgaccagcc gacaccgcct gcgctcacca gcttcctgca 3840
cagtgcgctc gatcgcctcc acgccgcgca cgaggaggag gacgcttccg gctccccggc 3900
cacggatgac ggcttcgcgt cgaaggactc cacggtaggc gggctcgaca cgctcgggga 3960
gatgttccgt caggcctgct cggcggaccg gatcgaggag ggcatggaac tggtccgact 4020
cgcctcgcac ttccgaacca cgttcgaggc actggcccag ctcgaacagc gtccccatcc 4080
ggttccgctg gcgcgcggga cgcgcgatcc actgctgatc tgctttcccg ctgtggtggc 4140
gatgtcgggg gcccatcagt acgcgcgctt cgcggcggcg ctgcgtgact cgcgcgacac 4200
cgtcgtcctg ccgcagcccg gcttccttga cggcgagttg cttccgggca gcatcgaagc 4260
actggtggac atgcaggccc gagccgcact tgagtacgcg gacggcgcgc cgttcgccgt 4320
cctcggctac tcctccggag ggtggatcgc gcacgcggtc gccgaccgtc ttgagaagat 4380
ggggcatccg gcgcgcgccg ccgtcatggt ggacacctat ctggcgcacg agatgacccc 4440
tcgcctccaa aaggccttca cccagggcct gttcgcccgg cgtgagcagt tcgtgtccat 4500
ggaccacgtg tcactgacgg ccatggccgg ctatttcgag gtgttcggcg cctgggaacc 4560
tcgtccgctg tccactccca ccctgttcgt ccgtgccgcc aacgcgttgc ccgactccga 4620
cggcagcccc ttggcggacg cggactgggg cccgacgtgg tcgcctgtcg acgcgtccct 4680
caagacaccg ggcgaccact tcaccgtcat ggaggaacac gcggacagta cggcgcgagc 4740
cgtcgacgag tggttcatcg gcctcgacgc cccgggctcc ggtaccgggg cgtgaccttc 4800
cctcccctca gacatccggg caggcctgcc cggatcgttc cacccacaag gagatcgcac 4860
atgactgaga tcacccccga gttggtcgcc gcggcttacg aggcagtgag ttccggggat 4920
cgcgagaaga ccgcccagta ctggtcggag gatctgcgtt tcctggctcc cggcagccat 4980
caccacgccg gctggagggt cggaatcgac gatttcctgg catacgtgca gggaatgctg 5040
gaggcttccg ggggctcctg gagcatggag cccgtcacgc tcctcatcaa taacgacgac 5100
ggctactcga tcgacgtcaa caaaatccac gcagtccgaa aaggagcacc gaaggacagc 5160
aagtccccgt acgacgtcct ggacatctca ggagtgcaga tgctaaattg gcgtgacggt 5220
agggtcgttg agggattcgg cggaatattc ggcgccgggg cgagcaatta cgaccagtgg 5280
tggtcaccga tcagcggtga cggggaacgt cgctacctct gaatcggaac gtgtcggcgc 5340
agcgagccgt gtccagcccg ctgcgccggc cactccggcc attttccttt ccgagcacag 5400
tctctgcatt cgaccatcgc accaaaacgc tggccggatt ctgccaccca aaggggaaga 5460
cgtgtctcaa aatcaggaag acgacaccga attcgacata ttttccccgc cttccgggga 5520
gaaccccttc gccgtgtacg acggcatgcg cgggcggtgc cccgtggccc gcagcgagcg 5580
gctcggcggc tactggatcg ccactcggca ccaggtcgtc gaggatgtcg ccaagaaccc 5640
cgatctgttc tcctcgtcct ccatcagcgt gcccaaggac gccttcggtg acgagttggc 5700
cgagcggcca ccgatcacct tggacccgcc tcggcacggg cctttccgta agctgttgct 5760
gcccgccttc ggccctcggc agatccgtcg tatggagccg ttggtccgcg agcacgcccg 5820
ggaactgctg gcggagatcg agccgcgggg ccactgcgat gcagcggcgg agtatgcgaa 5880
gaagatcccg ctgcggttca tggctcggat gatgggatgc ccgccggagc agcaagaggc 5940
cttcggtgaa cgcatgcgcg ccattctgga ctccaacgac atggacgaga tccagaacgc 6000
catgtcggag acccaggaat ttctccagga gttgatcgaa gatcgaacga agaatccgca 6060
ggacgacctg gtcgggctga tactctcgac cgagatcgac ggaatcaagt tgaatgccga 6120
agagttgctc ggtgcgcttg ttctgatcat tactgcgggt atcgacacca cgtggagtgc 6180
tattggcagc agcctgtggc atttggctcg cactcctgaa gaccgggccc gtctctccgc 6240
ctcacccgaa ttgatcccgt ccgccgtgga agagtttctc agatcctatt ctccggttca 6300
gatagcccgg gtcgtcacgc gcgacaccga ctttcacggg gcccggctga acaagggcga 6360
ttccatcctc atggggattc cgtccgccaa ccgcgatgcc gtagagttcc ctgattctga 6420
ccgggtggtg atcgaccgcg cgacgaaccg gcatctcgcc ttcggcgtcg gtattcaccg 6480
ctgcatcggc tccactgtcg cgcgtcttga gatgcgcgtg gccctcgaag agtggctgcg 6540
ggccattccg gacttctcct tggccggaga cgatccggtg acctggtcca ccggtcatgt 6600
ctggggacca cgccggctcg acgtcgaatt cggaggcagg catggaagtc cggcttgaca 6660
ccgagaaatg ccaaggccat ctgcgctgca tggacatcgc tcccgacatc ttcgactgcg 6720
acgacctcgg ctacggcgtc gtcgtcctca gcggtccggt ccccgcggag gccgttgaac 6780
gggtgtcgcg ttgcgtctcc aactgccctg agagcgcgct caccctgcgg tgagcgaccg 6840
cgccgcccca ccaccatccc cccagatacg gagttcccca tgtctctcgg ccaggctccc 6900
gcacccaatg acgtcgccgg cttctacgac gggatcggtc aggtcctcaa caccgtgtgg 6960
ggccccaacc tccactacgg ctactgggag aacgacgcgg acgacacttc catcgaggag 7020
gccacccacc gcctcaccga cctgatgatc tcgggtctcg cgccccgggc cggagggcgg 7080
gtcctggaca tcggctgtgg catcggcaac cccgcgctgc ggctcgtcgg cgcccgcgac 7140
gtgaacgtgg tggggatcac cgtcagccat gtccaggtgg cgcaggccga ggagcgcgcg 7200
gcccaggcgg ggctctccga ccgggcgacc ttccagttcg cggacgccat ggacatgccc 7260
ttccccgacg cctcgttcga cggggcctgg gcactggagt cgatgctgca catgccggat 7320
cgcggcaagg tgctcgctga ggcagcccgg gtcattcgcc ccggcggccg cctcgccatc 7380
gccgacatca tcgaacgcgg accggtcagc cccgagggcc gtgtggtcct tgaccacatc 7440
tgcgagacct acaaggtgcg ttccctcggc accatggacg aataccgcga gacgctctcc 7500
gccaacggct tcgtcgacgt ggagatccgc gacatcagcg acaacgtctc ccgtaccggc 7560
gccatcctcg ccgatgtagt ggagaccgtc cgcgacaagc tcgtcgcgca ggccggtgag 7620
gagcaggtca cctcgctcat cgacttcatg cgccgcgcgg cggccactcc ggagaacggc 7680
tacctcttcc tgaccgcggt ccgcgcatga ccgaaggtgt ccccgagccc ccgcccatca 7740
cccgaaggga gacccctgtg gccggtgaag cgccgcgaac cgacttcgac caccattccg 7800
ctgagtacgg tcgtgacccg tgggccgcga acatcgcgat gaacacccac tgcccggtgg 7860
cctacagcag ccaccacggc ggtttctaca tcgtcacggg cttcgacgag gtgaccgacg 7920
tggcccggcg ccccgaggtg ttctcctcgg cgcacgaggt gcccaacacg ccggggcgcc 7980
cgcagggcac cgtggttccg gcctcgtcct tccgggggct gccgctggag atcgacccgc 8040
cggagtatct gcagtggcgc cgcgccatga acgagttctt ctcaccggcg gccgccaaac 8100
ggctgcggcc gcgtatcgcc cagtacgcgc gctggtgtgt ggaccagcac atcgagagcg 8160
gcgagatcga cctcgtactc gacctgtcca atcccgtacc cgcactgatc accctggacc 8220
tcgtgggcct gccgctcgac gactggcgcc tttacgccga cgtggtgcac gcgttggcct 8280
acacgcaccc ggggaccgac gaattcgacc gggtcgaggc ggggttcgcc caactgatcc 8340
agacagtgcg ggagttgata cccaagcggc gggcggaccc gggcgaggac ctgatcagtt 8400
tcctcaccca gctcgaaatc gacgggacga agatccccga cgaggacatc gtcgccgtct 8460
gcaacgccgt catccccggc ggtgtcgaca ccaccacggc gctgctctcc aacaccttcg 8520
agttcctcga ccgcagcagc ggggaccgac agcgtctgat cgacgccccg gagacgatcc 8580
ccggcacctg cgacgagttt cttcgctact tcacaccggt ggtcggcgcg ggacgcaccg 8640
ccatgcggga cgacagcgtc ggcggctgcc ccgtcaagca gggggagcgt gtcctggtct 8700
cctgggcggc cgccaatctc gacgcgaagg tcttcccccg tcccgacacc atcgacctgg 8760
accgcgacgc acggcgccag gcggccttcg ggatcggcgc gcaccggtgc atcggccggc 8820
acatcgcccg gatggacttc gaggtcatgg tcgaggaggt gctctcccgc ctgcccgact 8880
accggctcgt cgagggcgcc gcacagcggt atccgacggt gggccaggtc aacggcttcg 8940
tgcggatgcc cgcccgcttc accccaggac cacgccgggg ccccgccgtg tccagcgcgg 9000
cagagctgcg cgccctgccg gtctgaagcg gccccgccaa cacacccaca tcagcgaagg 9060
accacccatg gcgcatgagg gaagagtgct gcggctcgga gccatcatcg acgggccggg 9120
cggccacgtc gccgcctggc ggcaccccat ggccccggcc gactcccagc tcgacttcgc 9180
gttccaccgg cgcaacgccc ggacactcga acgaggtgtg ttcgactgtc ttttcgtccc 9240
cgatgtcgtg gcggtctggg gcacggacgt cgagcacctg agccgcacgg cacgcaacga 9300
gcacctcgaa ccgctcagtc tcctcgccgc gtacgccgcg gcgaccgagc acataggact 9360
cgccgcgacg gcgaccacca cctacaactc cccctacgat ctcgcccgta agttcgcgtc 9420
actggaccac atcagcggcg gccgggccgg ctggaacgta gtcacctcgg cggccccgtg 9480
ggagtcgcgc aacttcggtt tccccgagca catggaacac gacctgcgct atgcacgggc 9540
cgaggagttc cttgccgtgg cccgacaact gtggtcgggc cagccgtgga cggagggaac 9600
caccggcgac ggcacccgcc gaccgccgat cgaccacgag ggcgagttct tcagcgtccg 9660
cggcccgctg aacctgccgc ccacgccgca ggggtcgccc gtcatcttcc aggccggtgc 9720
ctcaccggtg ggccgcgagt tcgcttcccg gcacggcgaa gtgatcttca ccaggcatac 9780
ccggctctcg gacgcgcagg acttctacgc cgacctcaag gaccgcgcgg tcagacacgg 9840
tcgacagcgc gacggcatcc agatctggcc cggactgcaa cccatcatcg gcagcaccga 9900
ggccgaggcc aaggagcgcc tgcgggagct tcaggaactc gtgcccgaca tcgtcgccct 9960
gcgggccctt caggaccagc tcggggacct cgatctgacg ggctacccgc tggacgggcc 10020
cgtccccgag atccccacat cgaaccactc gcacagtacg tccgaacgct ggatctccct 10080
cgcccgccgg gacaatctca cgctgcgcca actggcgatg cggcagaccg gcgacatcat 10140
cgcgggtact cccgaacaac tggcggacca catggagtcg atgttcaccc ggggagcagc 10200
tgacggcttc atcgtcgact tcccctatct gcccggggca ctcgacgact tcgtggacca 10260
ggtggtcccg gaactgcgcc gacgcgacct cgtgcgtacc gcgtacacgg agggcacact 10320
gcgcgacaac ctgggcctga aagcgccgct cgccgcagcc ggggcaggtg cggcatgagc 10380
gtacgcaccg gacggccggt cctcctcgcc cccctcgtca ccgcgggcgg cccctcgggc 10440
gtggaggcct tcacgcgtgc gcggcgacgc gccctcgcct gtgagcaggc cgaggtggac 10500
gcactgttgc tccacgacca gcaatccgcc gcggggcacg cgcgacgcct cccggatttt 10560
gaggcaggca cactcgcggc cgccctggcc gtggccaccg agcacatcgg gctgatcagc 10620
gccgtcagca ccgcgcagct cgcgccgtac cacgtggccc gtgctctggc caccgtcgac 10680
tacctcagtt ccggcaggtc gggctgggag gccgccgcgc tggacgacga ggccgcggca 10740
gccgaacgga ccaactacgg tgcgccggca cacacgccag agcgggacat cgcctcagcc 10800
gacctccggc gggaccgggc ggcggagttc atcgacgtgg tgcgggggct gtgggacagc 10860
tttcaggacg atgccttcct gcgcgaccgg aactccggcg tctacttcgt gccggaccga 10920
ctgcaccagc tcgaccaccg gggggctcac ttcgacgtgg cggggccgct gaacatctcc 10980
cgtcctccgc aggggcaccc cgtcctgctg cggcgggtgc gcgaccccga agacctggcc 11040
cccatcggcc gcagcgccga catcgcggtc gtgcccgcga gtgaggagaa ccaggagggc 11100
gccgcccgca ccatacgcga cacggtgcga ggccatgccc gagaggcagg gcgcgaggag 11160
gacgacatcc tggtcgtcgt ggaacaccgg gtacgggacg gcgacaccga agccgccgcg 11220
gcgcacctgc gggagctctt cgcgtcccga gccgccgacg gtttcgtcct gctggcgccc 11280
gagaggccgg aggacgccgc gcacagcgcg ctggtggacc tcgcttcagc tctgcgccgc 11340
cgcggtcccc acccggctcc tccggtcgac ggcaccctgc gcgcccggct cgggctgccc 11400
cgccccgccg gtctgcaccc gacagcctga ccgaccgacc accccgaacg ggtcaccacg 11460
gcccgcacca catggaggac cgctatgcgg cgcacagcta tcgtcaccgg aggcggatac 11520
ggaataggcc gtgccgtcgc cgaacatctc ctcgcccagg acatggaggt ggtgatcacc 11580
ggccgccgcg ccgagatcct cgaacggacc gcggccgaac tggggccgct cgtcacaccg 11640
ctggcattcg acgcctccga ccccgccgcc gtcgaggcag cgctcccaca actccccgac 11700
cgcgtcgacg tcctggtcaa caacgccggt ggcgccactg agtacgatca cgcgatgccc 11760
ccgagggagc agctcaagga gttgcgcgag gcatggctgc gcaacatcga cgcgaacctg 11820
atgaccgccg tcctgatgac ctccgcactt gagccccgca ttcccgacgg gggcagcatc 11880
gtcgtgatcg gctcgatcgc cgcgcgcggc ttcggagcga gcggttacgg atacgggccg 11940
gcgaaggccg ccctggagcc ctgggcgacc gatctcgccc acgaactggg cgcgcggggt 12000
atcagcgtca acgtcgtgtc gccgggtttc accgtgagca acgaccgcgc acgtgacttc 12060
gtggccagcg gagacgccag cccgctgatc gaatccggcg cgaccaagcg ggccaccgag 12120
gtggacgacg tagccgccat ggtcgctttc ctcaccactc ccgccgccgc acagaccacg 12180
ggtcagacca tccatgtcaa cgggggtacg cacctgggcc gttgagcaga ggaaccttcc 12240
tggtcccgtt ccccacactg tgagaggcac accacagatg acgacctcac ctccggaccc 12300
tgtcgacttc cccttccccc cactgcgcgg ccccggagtg gagaaggagt acggcgaact 12360
gcgccgtgcc tgccccgtca gccgggtgcg actcccctac ggcggcgacg cctggctggt 12420
cacaggacac gagcagacga agaaggtcct ggccgacgcc cgtttcagcc gagccgcggt 12480
ggtcggcgag gatgttccgc gtatccagcc caacaacctc gcggaagagg gcgggatcct 12540
cgacacggac cctcctgccc acacccgtct gcgccgtatc gtcgcccgga tcttcacaca 12600
acggcacgcc gagcggctgc gtccgggtat caggaccatc accgaccggc ttctggacga 12660
gatggagcag cgtggcggcc cgctggacct ggtgcaggaa ttcgccctgc ccatccccat 12720
ctcgaccgtg gtcagtgaac tcctcggcgt acctgccgag gcacgcccca agttccgcga 12780
atgggccgac gccaccctgt ccacgaccaa gcggtcggcc gaggagatca cccaggcccg 12840
ccaggaactg cgcgcctact tctccgaact gatagagaaa cgccggcgcg agcccgccga 12900
cgacctcatc tccatgatgg tccgggccaa ggacgaggag gagcggctca gcgagagcga 12960
gctgatccgc atggccgagg acatcatgat cggcggccat gagacgaccg ccaaccgcat 13020
cgccaccttc acctacgtcc tgctgaccca ccccgagcag atggcccgcc tcaaggccga 13080
tccttccctc atcaccaccg cggtcgagga actcgtgcgg tacgtgccct tggactcggc 13140
gagcttcgca cgcatcgcca cggaggacgt cgaactgggg gaggtcaccg tacgcgccgg 13200
tgaggcggtg ctccccgcgc tgctcgcggc caaccgtgac gaatccgtgt tcacggaccc 13260
ggaccggctg gacctgggcc gcctgcgcaa ccagcacatc ggcttcgggc acggtgtgca 13320
ccactgcctg ggtgcgcagc tgggccgcgt ggagctgcag gaggcgctgg ggtccctcat 13380
cgcccggttc cccgacctcc atctggcagc ggatccggac gacatcccgt ggaagaccgg 13440
ggggctgctg cgtggccccg aacagctcat ggtcgggtgg tgagtcacga catggcgaag 13500
gactgctggc gtatctcggt cgacaccgag gtgtgcatcg gctcgggtgt ctgtgtgggg 13560
atcgctcctg accacttcca gctggtcgac gggcgttccc agccgatcga ggaacgcgtc 13620
gacgaggacg aactggtcag ggacgcggcg gacaactgcc cggtcgaggc catctccgtg 13680
cacgacggca ccggacggaa gatcgcaccc gatctgtgaa cggccgcagc ccggaatccc 13740
gagcaccacg gtggtgggcg tcccgggctg ccccctgtcc ctcctgacac ttccacctcc 13800
ctgaatccag acgggctgag caccggacat gaacctgcct gcctctgccg ggccttcgcc 13860
cgggacgcgt gcgctcaaca gaaagcggac acgcgacaca ctggtccacg cggctctcga 13920
cctcttcctg cggcacggct acgacgagac cacggtcgag gagatctccg ctgtcgccgc 13980
tgtgtcgcag cgcaccttct tccgctattt cgacagcaag gaggatgtcg cgctcagctt 14040
tcaggaggct ctggaacagc agttgatcca ggccttgcgt gcgcgcccgg ccgaggagcc 14100
tcctttgacg gcgttgcgcc aagcctcgct ggtcacctgg gggaaccttg agcgcctctt 14160
cgaggaggtc gcctcctatg agctgtgcgt gggcatgccc cgtctggtcg attcctcgcc 14220
cgggctgctc ggagcccatt tacgcagggc catcgccctt gaagaagaac tggcacttga 14280
gatcgcccgc agggaaggtg tcgacccgga cctcgatcta cgcccccgga tcctcgtggc 14340
ggccgtcttc ggcgcgatgc atgtggtcaa ccgcgtctgg agccggcagc acccggagga 14400
cctgtgggcg ctgcgggccc tcaccctcgt gcacctggac cagttgtcca cggcactgac 14460
cagcgactgg ctcccggaca ctccgctgac cagaacacca gagaaatggg actgacgatg 14520
cccgacttcc tccacaccct gcgcgactgg tccatgtcgg ggctccggtt gcagtcgatg 14580
atccggaccg cagagcgcgt ccccgccgtc cccgacactc ttcgctactc cttcgggctc 14640
gtggaccgtc ccatgtatgc ctacggtgcc cgcaaggccg tcgagctggc cgcctcggcg 14700
ggctacagcg gggtgacgct cttggagttc ggcgtcggat ccggtggcgg cctccaggct 14760
ctgagccggc acgcccggca ctattcccgc agcagtggcc tcaatgtgca cgttgtcggc 14820
ttcgactcgg gatccggact gcccgagtcc accgactacc gggacctcct ctacgtatgg 14880
aacaagggcc agtaccccat ggacagcgcg gacctgcgcg accagctccg gggatccgcc 14940
gaactcgtcc tcggcgacgt ggccgagacc gtgccggggt tcctgcgcac ccacagcgag 15000
cacctggcaa ggaacccgct cgggttcatc tccttcgacc tggactacta ctcctccacc 15060
gcctccgcct tcgagatatt tcgcagcgca cgggacgaac agctgctgcc ccgtatcacc 15120
agctacttcg acgacatcat caccatcctg gacaggaccg gggaactcgc cgccatcgcg 15180
gatttcaacg gcgaggacaa gcacgggtac atcggcaggg tgaacgcctt gcgaagccat 15240
ctccccttcg acccggcctg ggctgaccag atcttcgagt accaccgttt cgaccaccgt 15300
gactacaacc gccacgagtc ggcgcgcgac agcccgacat ggcggccctg aactcccttc 15360
cccccaccgg atccgacaga ggcgaggcac gcatggtgga tatcgacgaa ctggccgaga 15420
acttcgaccc ctgggacata cgtctggccg gcgactccga actgttctgg gctgtcgtgg 15480
agcgtatgcg gcagaagggc ccggtgctgc gcagcaccgc ccagggagga ttctggatca 15540
tcaccggcca tgacgaggtg ctacgggcca acaaggactg ggagacctac acatccgccc 15600
agggagtgac cattcccagc aaccccgacg tgccgaaact cgcaccgatc gaggtcgatc 15660
ctcccgtgca ccgcgagtgg cgccgcatgc tcaacccttc gatgtctccc gcggccatgg 15720
ccaggcatga acccgccata cgcagcatcg cggtggagct gatggatcag ttcgtcgagc 15780
gaggggagtg cgacctcgcc acagacttcg cctggcagtt cgtccccgcc tccctgttcc 15840
aggtactcct cggggtgccg gtggaccagg tggaacgcac caggcgactg gtgcacaggg 15900
tggtgtcgtt cgaggacctg gacgagcaga cgggcgcgcg gggggagagc ctgcttgagc 15960
agcagaacaa ggccttcgcc gatctgaacg agtgggcccg cggcttcctc cagtggcggc 16020
aggaacgccc ccgcgtcaac gacgtcaccg acgcgttgct gcacggggag gtgtccggca 16080
agcccctgag tctccaggag aaggtcaaca ccctcatcct cctcgtgctg gcgggcatgg 16140
agaccacctc aagcagcatc agcgctatcg ccctgcatct catcgaggat ccctcgctgc 16200
gccactactt ccatggccca gaggcccccg tcgagacggc catcgaggaa cttctgcgcc 16260
atggctcgat ctccttcggc ctgacccgcg tcaccacatg cgatgtcgag gtcggcgggc 16320
aggtcatccc ggccggggag cgggtattcc tcctgtgggc ttccggcaac cgcgaccccg 16380
aggtgtttca ggaacccgcg cggttcgaca ttcatcgcag acccaacgcg cacctggcgt 16440
tcggggccgg cccgcaccgg tgcatgggcg ccaacttcgc caaggccatg ttgaaggtgg 16500
ccaccaccga gatggtggcg cgattgcctg aactgcgact ggatcccgac ggcgtggccg 16560
tccacccgcc cggtgtgacc cgcagcacca ggtcgctgcc cgtgcttttc cgtcccacca 16620
gcccgagttc gggcctcagg actttggaga gcgcgccggc tcccatctga ccgaccggcc 16680
ttcactgtcg cgactgcacc gcccggcctg ccctgccctc tgacactgac tcggaattac 16740
tggaggaacc ccttgctccg tggagaccac gccgtgaccg ccgccactgt ggcggagtac 16800
tacaaccaag ccaccgaact gatcagtgcg gatctgggtg gcagcctcca tttcggctac 16860
tggcacggcc tgccggagaa cagctccatg caggacgcct cccggcagat gaccgaactc 16920
atgatcagca agctgtccgt cggtccgggg caacgggtcc tggacgtcgg ctgcggcgcc 16980
ggccggcccg ccgcggacct gtcacgggcc accggcgcct ccgtcgtcgg cgtggacatc 17040
agcccgcggc agatcgagct ggcgacaggg ctcgccagga cagaaggcat ggaggacaag 17100
ctctccttcc agctcgccga cgtgatgagc ctcccgttcg aagcggacac cctcgacgcg 17160
gcctggctgt tcgagtcgat gttccacatg ccggaccagt cccgggttct ggaggagatc 17220
gcacgcgtgc tccgcccggg aggacgtgtg gccatcgcca acctggtgca gcgggtgccg 17280
ctcaccgagg agcagaacgc cgcccttgag gagtactgga aggtcggcaa cgttgccgcg 17340
ctgctccctc tggaggacta cccgaagctc ctcagcgaca gcggtctcgt cctcaccgag 17400
ctggcggaca tctcggagga caccacgggc ccgacattcg aggccatcgg ccggacacac 17460
gccgcccgag ccgtcgggca caccgagtcg ctcgcacccg gggaactggc ctcgcaaatg 17520
ggcgcgggga tggaccagtt catcgccaca ccggagatcg gttttgccat catcgtcgcg 17580
tccaaaccgg gctgaccaca cctggaacac gccccctgac gctgtccgcc gcgcccggcc 17640
ggggcggtgg acctgtcgtg tccaccgccc cgcccggtcc gccactcaga tccggctgcc 17700
cctcggccgg tatgccctcg acgcgggcag gtcggagtac cgtccgctct gcccgcgcga 17760
gagcggaccg tgaccgcgag gacgtgggcg aggtcaggtg gaatacccct cgcactactg 17820
cccagccgcc ctggctcgta ccgctggtga cacgacgtcg gggcctggct gcgctgtcgc 17880
ggttcggccc cggcgtgacg taccgacgtg gctcagctct gtgtagtggc gctccgacgc 17940
ggatggcgcc gggtaccgaa ccgctcgtcc ggctcgtact cctcctcgtt ctgcacgcga 18000
cctctcgccc gtccgcccat cccctccttg tcgcgtccac ggcccgcgcg ggccgtcctg 18060
gcaggcagga ccgccgcgtg cgcgcggggt ccgaggacct gctcgccgct ggtgagcggc 18120
accgcgtctc ctcaaaggac cccctagaga cccgccgtac gggcttttag gggtgcgctc 18180
cgtctccgta gggggctgac gggtcaatga cccgctcctt atgctcaagc cattcccgta 18240
cggagagtcc cgcttgtcgt gccgggttcc gtgctggtcg cgacaggcgc ggaaggtgtg 18300
gtgcggcgcc cgccgtccca tcgtgcccgt cacgtccggc cgagcgtgtc cggagtcgtg 18360
ttcctcggtt ccccctgtcc ggcaggagaa gtgccggccc gagctgtccg ggtgccacca 18420
gctcgggcca ttcatacgaa aggacgatga catgaccagt ggggtggcgt tcctcttccc 18480
cggccagggg tcgtacgtgc ccggcgtctt cgccggtatc ggcgcggacg ccgatcggat 18540
atcggcacgt gtcgaggaga tcgacgcggt cctggccgag tttcatttgg ctccggtgcg 18600
gccgctgttg ttctcaccgg acgctcccac actggcacag ttgctcgcgt ccgatcacga 18660
gcgtctcgat gtggccatcc tggcgacctc catcgccctg gcggagcttt tggactcccg 18720
ttacgaggtg actcccgatc atgtggtcgg gcacagtctc ggggagttcg ccgccctggc 18780
cgtggcgggg gtgttcaccc cgggcgaggc cgccagggcg gtctgcgagc gccacgccac 18840
cctgcgcaag gcgccgccgc ccgagggcgg gatgctcgcg gtgaacgcgg acaccgcccg 18900
tgccgaggag ctgatcgctt cggcgcgggc cgaggcctcg gccgtatcgg cgcggaacgc 18960
cccgagccag acggtggtca gcggcacgga agcggatctg gtggaggtgc ggcggctggc 19020
caaggaggcg gggatccgca cgtccaggct ccatgtcccc ggccccttcc acgtaccgca 19080
gttggcggac gcgagtgctc tctacgcgac gacgatgcgg accgtgcgga tgtccgcgcc 19140
ccgcgagggt ttcttctact cccacggcct gggccgcttc ctgaccgcgc acgacgacgt 19200
ggtcgatctg atggtggccg acatgacccg gccggtccgt ttccacgaag cggtgcgcgc 19260
gatgaacgcc gagggtgtca cgaccttcgt ggagtgcggt gcgctggacg tcctcaccag 19320
gatcgtctcc gggacgctgc cccacgcggt gactctcgca ccgctctccg aggccatgac 19380
cgtccccgat ctgtccggcc agctgcggtc ggcgcggccg tcggccgtgg ccgacgctcc 19440
cggggccgcc gagcccgctg ccggggccga cgcggaggtg ctggagggag tacgcgcggt 19500
gtgcgccgag atcctggagt atccgcttga ggtggtcacc gacgacgccg acttccaggc 19560
cgatctcggg gtcgactcgc tggcgatgac cgagctacag gaacgcgcac tgcgccggtt 19620
cggcctggcg gacaggctca acgacgccaa cgccggtacg tacgccaccg tctccggcct 19680
cgccacgtac atcaccgggc tgctgcgcga gggcgccacc cccgccgccg aacagcggtg 19740
agccggtcgt gacctccagt ggcccggacg acgcgggcac acgcgcggac gccgtcgccg 19800
tggtggggat gggcatcgct gttcctgggg cctgcgacac ggacgagctg tggaaggtac 19860
tgagcgggga ccggcccgtg ttcgaggagc cgggggaccg ctatccgctc ggctccttct 19920
ggtcccggga ccacgccgcc gaggaccggg gctacgtccg cacgtcgggc ttcctgcacg 19980
acttccggcc gcaccccgac ctcgcggagg agatcgccgc gggcaccttc tcggccgccg 20040
accagaaccc ggtctggctg cggcactgcc tcctgcgggc ccgggacacc gtcaccgccc 20100
gcgccacaga ccgctacgcg tactacgtcg gcagcagcag cctcgtgggg cagcgcaccg 20160
acgaggcggc cctggccgag tccgtcgccc cgcacctcgc cgagcgtctg cacggggcgg 20220
accccgcccg gcgcgccgag gccgagaacc ggctgcgcgc cctcttgcgg cgccaccacg 20280
ggcacggccc ggggcggccg gtggacacgc tgccccaccg ggtcgcgcgg gccgcggcca 20340
ccgggctgct cccggacgac tgcgagttct ccgtggtgga cgccgcctgc tcgtcctcgc 20400
tctacgcgat cggcctcggc atcgcgagtc tgctggccgg cgagtgcgac atcgcctact 20460
gcggcggggt gtcgggcgtg acaccgcgct acaacgtcac cttctccaaa ctgcgcgggc 20520
tgagccccgg cggggacgta cgtgccttcg accgagacgc ggacggaacc ctcttctccg 20580
acggcgcggg catcgtcgcg ctcaagcgcc tggaccgggc cgtcgaggac ggcgacgccg 20640
tgctcggact cctcgtgggg ttcggcggct cctcggacgg caggggcacg gcgatctacg 20700
cccccaatcc gaaggggcag cgccggtgcc tcgaccgcgc ccggcggaat gcgggactcg 20760
ccgccgacga cgtcgactgg gtgatcgcgc acggcacggg cacggcggtc ggcgacgccg 20820
tggaactgaa aacgctggcc gagaccgctg gccccggcgg cctctggtgc ggttccaaca 20880
agtcactgct gggtcacacc ggttggagtt ccggagtggt ctcggtcatc cacgcgctga 20940
cggccctgcg ggagggcgtg gtacccgcgc agcgccgctt caccgcgccc ggcctcaccg 21000
aggagaccgg cgacagggta cgtgtccccg tcgaggacgt cccgtggcgc gaggacggcc 21060
ggcgtccccg cgtcgccggt gtctccgcct ttgggttcgg cggcgccaac gcccatctgc 21120
tggtcgccga ccgcaccccc gcgcgacgga tccgcgatgt ccggcccccg gagagcgacc 21180
ctgtggtcct cctcgcctgg accgcccacc tgcccgggga cccgggcccc gcggaggtgg 21240
cacggctggt gcgtgacggc cacgtgccgg ggccgcggac gttcgggccc cactatccgg 21300
cgccgccgtt ccaggacgtc cgcctgccgc cggccaccgt gcgatccacc gacgcgggcc 21360
agctcatggc cttgcgcgtg gcgtcccttt tcagcgccga gcacggtgag ctgtgggatc 21420
cggtgcgcgc caccaccggg gtcttcgccg cttccctcgg tccgccgccg tccgccatgg 21480
accacctggt gcgctgccac gccgccgagt tggacggcct cctcgacggc cccgaccgcg 21540
cggccttcac cgactggctc ggcgaactcc gcgccacgac tccgccgacc accaaggaca 21600
ccctgccggg catcctgccg ggcatcgtcc cggcacgcgt cgccaaccgc cacgatctcg 21660
gcggccccac catgctggtg gacaccggtg ccaccagcgg gctcaccgcc gtgcacaccg 21720
cggcgcggta tctggcccgt ggcgagctca acctcgccct tgttctcggt gtcagtgcca 21780
cggcccgtcc tgagttcgcc cgcttcatgg gcgtcgaccc cgagcgcgtc gcggaaggcg 21840
ccttcctcct cgccctggga cgcgcgtcgg tggcccgcgc ccacgggctg aggccgctcg 21900
ccggcctccg tacggcctgg ggcggcacgc ctcgtccccc ggtgcgcctc acctgcggag 21960
cggccggtgc ggggcagacc ttcctcggtg cggacggcgt cctcgccgtg atccgcgccc 22020
tgcacatcga cgcgcccgac gtcgccgtgg gccccgccag tggtgtgccg gggccggtcg 22080
tcaccctctc ccccaccgcc cacggctcgc cccgcaggca gacaaggacc agccgatgag 22140
tcaccttcgc gacgcagcgg ccacggacga cccgcaggcc gtcgccgcct gcgacgtccc 22200
cgccgggtac cgcgccgccg tcgtcctcgc ggcggatcag caggccgtca ccgcgacgcc 22260
cgtcggggac agggaccccc gtaggacggt ccatgtgcgg gaggtcgcca ccccgcagtt 22320
gggccacggc gaggtcctcg tcgccaccat ggccagctcc atcaactaca acaccgtgtg 22380
gtcggcgctg ttcgagcccg tgcccacctt ccgcttcctg cgcacgttcg gcaggacctc 22440
accggaggcg gcccggcacg acctgcccta ccacgtactc ggctccgacc tctccggggt 22500
ggtgctgcgt accggacccg gcgtacgcga atggaagccc ggcgacgagg tcgtcgcgca 22560
ctgtctacag ccggacctcc agacccccgg tggacacgac gacactctgc ttgaccccgg 22620
gcagcgggtc tgggggtacg agacgaattt cggcggcctc gccgaaatct ccctggtcaa 22680
ggccaaccag ctgatgccga aacccgcgca cctcacgtgg gaggaggccg cctcgctggg 22740
ggtggcgctc tccaccgcct accgtcagct ggtctcccac cacggggcgg acatgaagca 22800
gggcgagcgt gtcctgatct ggggagcggc cggcggcgtc ggcgcgtacg cgacccaact 22860
ggccctcaac ggcggcgccg tccctgtctg cgtcgtgtcg tcgcaggcca aggccgacct 22920
gtgccgccgg atgggggcgg agctcgtcat cgaccgcgcg gccgagaact tcaccttctg 22980
ggacgagcag gaccggccgc gcctcagtga gtggagccgg ttccgcagcg ccgtccgcaa 23040
cctggcgggg gacgacccga gcatcgtcgt cgagcacccg ggccgggaga ccttcggcat 23100
cagcgtcatg atcaccgcgc gaggcgggtc cgtggtcacc tgcgcctcga ccaccggcta 23160
tcagcacagc tacgacaacc gccatctgtg gatgcacgtc aaacgcatca tcgggtcgca 23220
catggccaac taccgggagg cctgggccgc caacgacctc gtcgtacggg gcagcatcca 23280
cccggtgctc tcgcagtcct ttcccctcga cgccgtcggg gaggccaccc gggccgtggc 23340
cggcaacagc caccacggca aggtcggggt gctctgcctc gccgaccgac ccggcatggg 23400
ggtgcgcgac cacgccctca gggcccgcaa actcgaccgg atcaacctgt tccagaaagg 23460
acggtagcgg tgagtgaccc cgaacacctg gacactgtgc ggaagttcgt ctcccaggag 23520
atcctgggtc gggaaaccca cctcgactcg ctcgcggacg cacctctggc gctgtacgag 23580
cgcttcgccg ggacgggcct gatgaactgg tgggttcccg aggaacacgg tggcctcggg 23640
ctcggtctcg aagacagtgt gcgtatcgtc tccgaactcg cctacgggga cgccggggtg 23700
gctttcaccc tgttcctgcc catcctgacg accagcatgg tcagctggta cggcggtacg 23760
gagctcaagg agaaatacct cggccgtctc gtggcccagc ggggcttctg cgccacgctc 23820
ggcagcgagc acgaggccgg cagcgagctg gccaagatct ccaccatggt gcgcagggac 23880
ggcgaaagcc tcgtgctcga cggcaccaag gccttctcca ccagcaccga cttcgcccag 23940
ttcctcgtcg tcatcacccg ctctgcggac gacccgggcc agtacctggc ggtcactgtc 24000
cctcgggaca cgccagggct gcgggtcgac aaacgctggg acgtcatcgg cctgcgggcc 24060
tctgcgacgt atcaagtgtc gttcgtcgac tgccgcgtcc cctcggacca cgcgctgaac 24120
ggcaacgggc tgcgtctgct ggagatcggg ctcaacgcca gccggatcct gatcgccgcc 24180
accgcgctgg gtgtcgcgcg caggatccgc gacctgtgca tggagtacgc gaggacgaag 24240
tcgctcaggg gcgcgccgct cgtgaaggac gcggtgttcg tcggacggct cggccagttc 24300
gagatgcaga tcgaggtgat ggccacccag tgtctcgcgg cggcgcgcac ctatgacgcg 24360
acggccgcga ggccggacgc cgccaggacg ctgctgcggc agggtgctca gaagtcggca 24420
ctggccgcga agatgttctg cgggcagacg gcctggcaga tcgcctccgc cgcgtcggag 24480
atgttcggcg gcctcgggta cacgcacgag atgccgatag ggaagctgct gcgggacgtg 24540
cggcatgcct cgatcatcga aggcggcgac gacgtcctgc gtgatctggt cttccagcgt 24600
ttcgtcgtac ccaccgcgaa acgcacgtag cccggcccgt ataccgctct ccccctggac 24660
ccccctgact tgaggtccgc accaggagag gagcggggaa atccgccgag catttcgcac 24720
atggcgaatc aggtgacgac gtccgacgca ctcctcgctt acgtcaggga ggtgtccctc 24780
cgcgacgacg aggcgctgag ccggctgcga gcggagtcgg ccgggctgcc gggtggcggt 24840
gtggggacgt gctcgccggg ctgatcgacg aggcgggcgc gggccccggt tcgttcgacg 24900
tcgtgttcat cgacgcggac aaggcgggct atccggcgta ctacgaggcg gcgctgccgc 24960
tggtgcgcgg cggcggcctg atcatcgtcg acaacaccct gttcttcggg cgggtggccg 25020
acgacacggt gcaggaccct gacacggtcg cggtccgcgc gctcaacgcg gcgctgcgcg 25080
acgacgaccg ggtggacctg gcgatgctca cgacggccga cggcatcacc ttgctgcgga 25140
agcggtgaac ggaatgccgg ccgcggcggt cagcgtcagc gtgctgggtg tgggacgcgg 25200
cgagggctcc aggtgcaggc gttcgatgcg ccctgccggg tcacccagcg ccgacccgca 25260
cacgcagtcg ctctccgcga agccggcgaa ccggtaggcg atctccatca cgcggttgcg 25320
ttccgtgcgc cggaagtccg ccaccaggtg ggtcccggcg cgtgcggccc ggtccgtgag 25380
ccagttgagg atcgtcgcac cggcgccgaa cgacacgacc cggcaggacg tcgcgagcag 25440
cttcaggtgc cacaccgacg gcttcttctc cagcaggacg atgccgacgg cgccgtgcgg 25500
gccgaaacgg tcgcccatgg tgacgacgag gacctcgtgt gcggggtcgg cgagcagcgt 25560
gcgcagtgcg gcgtcggagt agtgcacgcc tgtcgcgttc atctggctgg tccgcagcgt 25620
caactcctcg acacgggtga gttcctcgtg gcccgcgggt gcgatcgtca tgcgcaggtc 25680
gagggagcgc aggaagtcgt cgtcggggcc tgcgtacgtc tccctggcct gatcgcgcgc 25740
gaagccggcc tggtacatga ggcggcggcg ccgcgagtcg accgtggagg ccgacgggct 25800
gaactccggc agcgccggga gcgcggtcac tcgctcggcc ggatagcacc gcacctctgg 25860
caggtggaac gcgacctcgg cgcgctcggc gggctggtcg tcgacgaacg cgagcgtggt 25920
cggcgcgaag ttgagccctt cggcgatctt cctgacggac tgcgacttgg gcccccaccc 25980
gatgtgcggc aatacgaagt actccgccac gccgagccgt tccaggtgcc gccacgccag 26040
gtcgtggtcg ttcttgctcg ccaccgcctg gaggatgccc cggccgtcga gcgtcctgat 26100
cacctcgcgg acctcgtcgg tgagcaccac ttcgtcgtcc tccagcacgg tgccccgcca 26160
caatgtgttg tccaagtccc agaccaggca cttgacgatg gtcgtgtcgg tcatgaccgt 26220
cctctcaggc cgggagcgcc agcgcgtgcc gcgccagtat catccggcac atctcgctgc 26280
tgccctcgat gatctccatg agtttcgcgt cgcggtacgc ccgctcgacg acgtgcccct 26340
cggtcgcgcc cgcggaggcg aggacctgcg cggcggtcgc ggcacccgct gcggctcgtt 26400
cggcggcgac gtgtttggcg aggaccgtgg cggtcaccac ctcgggcgaa ccctcgtccc 26460
agcggtcgct cgcgtactcg cagacacgcg tcgcgacctg ctcggccgtc cacagatcgg 26520
cgaggtgccc ggcgacgagt tgatggtcgg cgagcggccg gccgaattgc tccctggtcc 26580
tggcatgggc cgtcgcggcg gttcggcagg cgcgcagaat cccgacgcag ccccaggcga 26640
ccgacttgcg tccgtaggcg agcgacgccg cgacgagcat cggcagcgac gctcctgagc 26700
ctgccagaac cgcgccggcc ggcacgcgca cgccgtcgag acgcaggtcg gcgtggccgg 26760
cggcgcggca acccgacggt ttctggacac gctcgacatg tacgccgtcg gcgtcggcgg 26820
gtacgaccac cgccgcgccg gaaccgtcct cctggaggcc gaagacgacc aagtggtccg 26880
cgtatccggc cgcggtcgtc cagaccttgt gaccgtggac gacggcggtg tctccctcga 26940
tccgcacgcg cgtccgcatc gccgaaagat cgctgcccgc ctgccgctcg ctgaagccga 27000
ccgccgcgag cttcccgctg gtcagctcct tcaggtacgt ggcccgctga ccggtgtcgc 27060
cgagccgcgc cacggtccac gcggccatcc cctgcgacgt catgacgctg cgcagcgagc 27120
cgcagaggct gccgacgtgc gcggtgaact cgccgttctc acggcttccg aggccgagac 27180
cgccgtgctc ggccgcgacc tcggcgcaca gcaggccgtc ggcgccgagc ctgacgagca 27240
ggtcacgcgg cagttcgccg gacgtgtccc actcggcggc ccggtcaccg acgaggccgg 27300
tcagcagcgt ctcacggtca gccattaccg tccttcagcc ggtggacgag ctcgaccatg 27360
gacacgacgg tgcggaagtt caccagctgg aggtcggagc cgccgatgct gacgtcgaac 27420
gtcttctcca ggaagaccac cagctccagc gcgaagagcg acgagaggcc gccctccgcg 27480
aacaggtcac gctccaccga ccagggcgcc ctggtcttgt tctcaaggaa cgcgaccagc 27540
tcacgcgcca cagggtcgtc cttgacgggg actgtcaccg gaacacctct tcgtagtcgt 27600
agaagccacg cccggtcttc cggccgtggt gcccgtcgcg gaccatgccg agcagcaggt 27660
cacaggggcg gctgcgctcg tcccccgtgc gcttgtgcag taccgacagc gcgtcgacga 27720
ggttgtcgat gccgatcagg tccgcggtgc gcagcggacc tgtcgggtgg ccgaggcagc 27780
ccgtcatgag cgcgtcgacg tcctcggcgg acgcggtgcc ctcccgtacg atccgagccg 27840
cgtcgttgat catcgggtgg agcagcctgc tcgtgacgaa gccgggcgcg tccttgacga 27900
cgatcggctt gcggccgagt accgcgagca gctccgcgac ggcggccatg gcggcctcgc 27960
cgctcctggg cccacggatc acctcgaccg tcgggatcac gtacgacgga ttcatgaagt 28020
gcgtgccgag caggtcctcc ggccgtttca ccgcgtcggc cagctcgtcg accgggatcg 28080
acgaggtgtt ggtgatgatc ggggtgcccg gcgcggcggc cgagaccgtg gcgagtacgt 28140
ccgccttgac cgaggcgtcc tcgacaacgg cttcgatcac cgcatcggcc ccgccgatcg 28200
cgggcagcgc ggatgtcgcc gtatcgagca cgccggggtc ggtctccgcg ggcccggcca 28260
cgagttgtgc catccgcagc tcggcggcga tccgggtccg cgccgccgcg aggatcgcct 28320
ctgacgtgtc cacgagcgtc acgctgacgc cgtggcgcag cgcgagtgtg gtgatgccgg 28380
tgcccatcac ccccgcgccg atcacgagaa tccggtgtcc cacgcctcct cctccttccg 28440
gtgtcaccac ggcagcgagt acgggtcgag cacgtcctca ggcgtcgccc cgatcgcggc 28500
cttgcggccg agaccgagtt cgtccgcgaa gccgagcagc acgtcgaacg cgatgtggtc 28560
ggcgaaggcg ctgccggtcg agtcgaggac gctcaggctg tcgatgtggg ccgccgcggt 28620
gctcggcgcc gcgcacaggc tcgccagcga cgggcccagc tcacggtcgg ggaactgctg 28680
gaattcgcct tccgtgcggg cctgcccggg gtggtcgaca cagatgaacg cggactccag 28740
caggaccctg ggcaactcgg tcttgccggg ttcgtcggcg cccaccgcgt tgacgtgcag 28800
gtgcggcagt cgcggctcgg gaggcacgac cgggccccgg cccgcgggca ccgaggtgac 28860
ggtggtcagg acatccgccg cggcgaccgc cgcctccgga tccgtgactt cgaccgtcag 28920
cccgaggaac gcgacgcggc ccgcgaagga ctccgcgtgg ccctggtcga tgtcgctgac 28980
caggatccgc tccatcggca ggaccctgct gagcgcgtgc gcctgggtca ccgcctgggc 29040
acccgcgccg atcagcgcga gcgtggaact gtcgggcctg gccagcagcc ggctcgcgac 29100
cgcggagacc gcgccggtac gcatcgcggt gatcactgcc gcgtcggcga acgcgatcag 29160
gctgccgctg tcgtcgtcga ggcgcgacac cgtgccgacg accgtcggca gccggaatcg 29220
ttgatagttg tgcggactgt acgagatcgt cttcatggtc acgccgacac cgggcacccg 29280
gtacggcatg aactcgatga cgccgggcac ttcagcgctg cgggcgaacc cactgcgtgg 29340
cggcgcctcg tcgaactctc cgctgccgag tgcggcgaag cctttgtgca gctcttcgat 29400
cagccggtcc atgatcgcgt cgcggccgac cacggagaga atctgcttga tgtcacgctg 29460
acgcaggatt ttggtctgca tgtgtcacct ccctttctcg gtcttgcttt cttggtcttg 29520
ctttcttgac gctgctttgt cgatgctgct ttgttggtcg gggctttcgt gcgtccggcc 29580
gggcccgcgg gtgctcgtgt acgggacagt cgcagtggtg ccgttcggta cggttccggt 29640
gtggctccct gactcatcgc aactcccggt cgatgaggtc gaagatctcg tccgctgtcg 29700
cctcctcgga cagcacaccg gccggttcgg cggggcggcc cgcacgctgc cagcggtcga 29760
ggagggcgcc cagacgggtc ccgatcgagt cggtcccgcg gtcgccgggg tcgatgccgg 29820
cgagcagtgc ctcaaggcgg tcgagttgcg tggacaccac agccgccggg tcgtcggggg 29880
acaggagttg gccgatacgg ccggcgagcg cgcgcggcgt ggggtagtcg aagacgagcg 29940
tggcggagag ccgcagaccg gtcgcttcgt tgaggccgtt gcgcagttgc accgcgatga 30000
gcgagtcgac gccgagctcc cggaacgccg cgtcctccgg gatgtcgtcc ggtcccgaat 30060
gccccagcag gacggccgcc ttctgtcgta cgagcgtgag gaggtccgtg tgaggcccga 30120
cctcgtcgcg ggagctccga cgaaccacct gtttggcacg gccacgcaac agcggtaatc 30180
ctgcggggag ttcacctgcc acggcgacga cactacccgt tccggcgtgt acggcggcgt 30240
catacacgcg catgccctgc tcggcggtga gcgctctcgc cccgccctcc cgcatacggc 30300
gccggtcggc gtcggtcagc tcgccggtca gaccgctcgc ctcgtcccac agcccccacg 30360
ctatcgacag ccctggcagc ccctgcgtac ggcggtgttc cgcgagcgcg tcgaggaaag 30420
cgttcgccgc cacatagttg ccctgccccg gcgtgcccag cacacctgcc gcggacgagt 30480
agaggacgaa tgcggcgagg tcggtgtgtt gggtgaggtg gtggaggtgc caggcggcgt 30540
cggctttggg tttaaggacg gtgtcgatgc ggtggggggt gaggtggtcg aggagggcgt 30600
cgtcgagggt gccggcggtg tggaagatgc cggtgagggg ttggggtatg tggtgcaggg 30660
cggtggtgag ttgggtgggg tcgctgacgt cgcaggggat gtgcgtgccg ggggtggtgt 30720
ccggtggcgg ggtgcgggag aggaggtagg tgtgggggtg gtcgaggtgg cgggcgagga 30780
tgccggcgag ggtgccggag ccgccggtga tgaggacggc gccctcgggg tcgaggggcc 30840
ggggaaccgt cagcaccgac ttgccgacgt gagcgccccg gctcatgacc gccagcgcgt 30900
cgcgggcctg ccgcatgtcg tgaaccgtga ccggtagcgg gtggagggtg ttgtcggcga 30960
agaggccgag gagttcggtg atgatctgct ggagccggtc ggggcccgcg tccatcaggt 31020
caaagggttg ttggacggtg tggcggaggt cggtcttgcc cagttcgatg aaccggccgc 31080
cggtggcgag gagggcgacg gaggcgtcga ggagatcgcc ggtgagggag ttgagtacga 31140
cgtcgaccgg ggggaaggtg gcggtcatct cgggggtgcg ggagtcggcg aggtgggtgg 31200
cgtcgtccag gtccacgagg tgctgcttgg gtgcgccggc ggtggcgtag atgtcggcgc 31260
cgaggtggcg ggcgatctgt acggccgccg cgccgacccc ggtcgccgcc gcgtggatca 31320
ggatcttctc gccggggcgc agcttcgcca ggtccaccag gccgtaccag gcggtcgcga 31380
acacggtcac caccgacgcc gcctgcggat acgtccaccc gtcgggcatc cggcccagca 31440
tccgccagtc ggcgatgacc gtggggccga agccggtccc cacgaggccg aagacgcggt 31500
cgccgggcgc caggtcgtgc acgccggatc cgatctccag gacgacgccc gccgcctcgc 31560
cgccgagtac gcccttaccg gggtaggtgc cgagcgcgat cagcacatca cggaagttga 31620
gacccgccgc acgtacaccg acccggacct cggtcggggc caaggggcgc cacggctccg 31680
ccgaatcgac cgcggtgagg ccgtcgagcg tgcccgtctg tgacggtcgg accagccacg 31740
tgtcactctg cggcacgatg agcggctccg gcacgcgagt gagacgggcc gcctcgaaac 31800
gccctcggcg caggcggagg cgtggctcgc ccagtgcgaa ggcgattcgc cgctgctcgc 31860
ggtcgagggt gacgccgggc tcggtctcga cgtggacgaa ccggccgggc tgctcggcct 31920
gggcggcgcg aaggagcccg gcagccgcgg cggtggcgag gggatcggtg gtggcgaggc 31980
ccccggtggt gtgcgggcgt gtcgtatgca cgagcagggg cttgtcggcg ctggtcaggg 32040
cctcaagcaa gtgggctgtc agcgtacgcg tcttggccgt cgggtcgtcg tcggtgccgg 32100
tgagcagggt gatgacgtcc acgtcgcccg tgggtatgtc cacgggtacg gggacctcgg 32160
tccaggccag acgcagcagg ccggcgccca tgggcgggga cagcgggcgg gtccggatcg 32220
tccggatctc ggcgaccagc cggccggtgg agtcggcggc acgcaggctc agcgtgtccc 32280
cgtcccgggt gagcatgacg cggagcgttg ccgggcccac ggtgaccaac cggaccccgg 32340
tccacgcgaa cggcaggccg ggggagctac cgtccggcac ggtgagggac acggcttgca 32400
gggccgcgtc gagcagggcg gggtgcacgc catagcgggg cgcctcggcg gccggctcgt 32460
cggagagggt gacttccgcg taggtcgtgt cacccgcccg ccatgcggcg cgcagtccct 32520
ggaacgcgga gccgtagccg taaccggcgg cggcgagttc gtcgtagaaa gcggtgaggt 32580
cgacggggtg cgcgttggcg gggggccact gaaggaacag gtcgggagtg tctggggtgt 32640
ggggggcggt ggctgtggtt gtggttgtgg ttgtggttgt ggtggtgagg gtgccggtgg 32700
cgtggcgggt ccaggcgtcg gaaccttcgg gccgtgcgtg gacggtcacc gggcggtgac 32760
cggtggcatc atcggcccgg tcgacggtga cagtgagatc cacggcaccg gtcaccggca 32820
ccacgagcgg ggtctcgatg accaactcgt cgatcgcgtc gcaaccgacc tcatcacccg 32880
cccgcaccac gagttccaga aaggccgtac ccggcaacag caccgtgtcc cacaccctgt 32940
gatcggccag ccaggaatga gtcgccaacg acagccgacc cgtcagcacg accccatcac 33000
tgcccggcaa caccaccgca ctcgacaaca gcggatgacc gatcccctca ccccccggca 33060
ggacgggacg cagccagaaa cgcttgtggt cgaaggggta ggtgggcagg tccaacagcc 33120
gggccgtggg ggtgacgggg gcgatgaggg tggtccagtc gacgggtgcg ccctgggtcc 33180
aggcctcggc cagggcggtg acgaagcggg gatggccgcc gtccccggta cgcagggacg 33240
cgacggtgtg cggctggtcg agggcgggca gcaggaccgg gtgggcgctg cattcgagga 33300
acagggaacc gtccagttcc ctgacggcgg tgtccatcgc caccggccag cgcagattgc 33360
gataccagta accgtcctcg acgggttcac tgatccagcc gctgtcgagg gtcgaccacc 33420
acgggattgt cggggcccga ctggtgatcc cctccagggc ctcggcgagt tcgtcctcga 33480
tcgcctccac gtgcggagtg tgcgaggcat agtccaccgc gatccgccgc acccgcaccc 33540
cgtcatgctc gtaccgggcc agaacctgct ccaccgcctc cggatccccc gcgatcacgg 33600
tggaggcggg cccgttacgg gccgcgatcc acaccccctc caccgtctcc acctccgagg 33660
cgctgagggc gatggacgcc atcgcgccgt gaccggcgag acgggcggcg atggtccggc 33720
tgcggcgggc cacgatccgt gccccgtcct ccagggtgag ggccccggcc acgcaggcgg 33780
cggcgatctc tccctgcgaa tgccccacca ccgcatccgg caccaccccg tgcgcccgcc 33840
acagcgcggc caggctcacc gccaccgccc acgacgccgg ctgcaacacc tccacccgct 33900
ccaacacttc gggcccggac agcatgtccc gcacatccca gcccgagaac ggctccaaag 33960
ccgccgcaca ctcggccatc cgggccgcga acacctccga ggcggccatc aacgccacac 34020
ccatacccac ccactgcgaa ccctgccccg gaaacacgaa caccgtccgc aacccgtcca 34080
ccgccacccc ggcgacacga ctctccccca gcagcaccgc acgatgaccg aacaccgcac 34140
gcccccgcac cagaccatcc gccaccccac cgaggccccc acccacggac aacccgcccc 34200
gcacatacac atccagccgc tccaccagcg acgccagact cgattccgta cgagcagaca 34260
ccggcaacgg caccaacccc gacaccgcac cctcatccgg cgcggtccgc ccacccggag 34320
gcagctcagg caccccctcc aaaatcacat gcgcattggt gccgctcacc ccgaacgacg 34380
acacccccgc ccggcgcgaa cgccccgacc ccggccacgg cctcgcctcc gtcaacagct 34440
caaccgcccc caccgaccag tccacatgcg acgacggctc atccacatgc aacgtccgcg 34500
gcaccacccc gtaccgcatc gccatcacca tcttgatcac accagccaca cccgccgcag 34560
cctgcgcatg accaatattc gacttcaacg aacccaacaa caacgggacc tcacgcccct 34620
gcccgtacgt cgccaaaacc gcctgcgcct cgatcggatc acccaggacc gtccccgtcc 34680
catgcgcctc caccacatcc acgtcgccgc cgctcagtcc ggcgttcgcc agggcctgcc 34740
gaatcacccg ctgctgcgcc ggaccattcg gcgccgacag accattcgac gcaccatcct 34800
gattcaccgc cgaaccacgc accaccgcga gaaccctgtg ccccttacgc tccgcgtcgg 34860
agagccgttc cacgacgaga acacccgcac cctccgccca acccgtgccg ttcgctgtgt 34920
cggcgaacgc gcggcagcgg ccgtccggag agagcccgcc ctgctgctgg aattcgacga 34980
atccggttgg ggtcgccatc accgtgacgc cgccgaccag ggcgagtgag cactcgccgt 35040
ggcgcagggc gtaccccgcc tggtgcagtg cgaccagcga cgacgagcac gccgtgtcga 35100
cggtgaaggc cggtccttgc agaccgtaga agtacgagat ccggccggtg aggacgctgg 35160
gctgcacgcc gatcgagccg aacccgccca tgtcggcgcc gacgccgtac ccgtacgaga 35220
aagccccaat gaacacgccg gtgtcgctcc cgcggagcgt ggccggcacg atgcccgcgc 35280
tctcgaacgc ctcccaggtc gtctccagca tgatccgctg ttgcgggtcc atcgccagcg 35340
cctcgcgggg gctgatcccg aagaaggcgg cgtcgaagtc ggcggcgtcg gagaggaagc 35400
cgccacggtc cgcgtccggt ccgccggtga ggcctgacgg gtcccagcca cggtcggccg 35460
ggaagccggt gaccgcgtcg ccaccgttgt ccagcatccg ccacaggtcg tccggcgagg 35520
cgactccgcc tggcaggcgg cacgccatgc cgacgatcgc gagcggatcg tcgcgggtcg 35580
cggcggttac cgaggccgct gccgggacgg ctgccggaac ggtgctcccc gccatcgtct 35640
cgtccagccg cgacgcgatg gcccgtggtg ttggatggtc gaaggccagc gtggcgggca 35700
gccggacacc ggtggccgtg gcgagccggt tccgcagttc gacagcggtc agcgagtcga 35760
caccgaggtc cttgaacgcc gcgtccgccg gcacggccgt cgcgtccacg tggccgagta 35820
ccgccgccgc gcagtcgcgg acgagcgcga gcagcgcggc atcccggtcg gcaccggtca 35880
tggcgccgag ccgctcggcg agcggaacag tcgtggcggc cgcccttcgc ggcacggaac 35940
ggcgcagccc catgaagaga ggggacgcct gcgcgttcgg atccatcgtg gccgccacgg 36000
cgaacgcggc gccggtacct gcggcggttt ccaacaggcg gagggccagt cctgctcgca 36060
tggggcggaa accgccgcgc cgtacgcggg tcctgttcgt gccgctcata gtgccggtga 36120
gtccgctgtc gtcggcccac agaccccagg ccagtgacag tgcgggcagc ccctcggcgc 36180
ggcgcgacgc ggcgagaccg tcgaggaacc cgttcgccgc cgagtagttg gcctggccgc 36240
gaccgcccag gatgcccgcg accgacgagt agaggacgaa cgcgcgcagg tccgcgcctc 36300
gggtcagttc gtgcagatgc caggctccgt ctgccttggg ccgcagcgtg gtggcgagcc 36360
gctccggcgt gagtgccgcg atcacgccgt cgtcgagcac cgctgccgtg tggaagaccg 36420
ccgtgagggg ccggtccgct gcggcgagcg cggcggcgag ttggtccttg tcggagacgt 36480
cgcagcggat gtggacaccg ggcgtgtcca ccggcggttc gctgcgcgaa agcagcaaca 36540
ggtggcgggc gccgtgctcg gcgaccaggc gccgagcgag gagaccggcc agcacacccg 36600
agcctccagt gatgaccacc gtgccttccg ggtcgagcaa cggctcgtgc gtccgtgtgg 36660
cggccgtccg gcggagccgg ggggcctcgt accggccgtc ggtgacgcga acgtacggtt 36720
ccgccagtgt cgtggccgcg gccagtgtct cgaagggggt gtcgccgccg gtctccacga 36780
ggacgaaccg gccggggtgt tcggcctgcg cggacctgac aaggccggcg accgctcccc 36840
cggtcggccc cgcgtcgata cggacgacga gagtggtcgc cgcgaggctg tcgtcggcga 36900
ccacccggtg cagctcaccg agtacgagcg cggtgagccg gtacgtctcg tcgagcacgt 36960
ccgcgtccgg ctccgggatc gctgagacga cttggacctc atccgcgtgg ccgggaccgg 37020
ctgtggagcc aggacccgct gagggggctg ggtcgactgt gggggctggg tcggctgtgg 37080
ggccaggacc gactgtggcg gctgccggag tgggcagctc ggtccaggag aggtggtaca 37140
gggagtcgcg gacggtggcg tcggtgtagg cgtcggtgcg gacgttcacc ggtcgcgcgg 37200
ccaactcgga gaccgtcacc acagggtggc ctgccgggtc cgccgcgtgc acggccacgc 37260
cattcgggcc ctgggtgatc gccacacgca acgtggtggc gccggtcgtg tggaaccgga 37320
caccgctcca cgagaacggc agcttcacct ccggctcgga ggcagactcc ggttccgact 37380
ccgacctgga ctccggctcc tgctccgatc cccgcccggt gagcagcggc aggcaggtga 37440
cgtgcagcgc cgcatcgagc agggccgggt gtacgccgta gctggacgcg tcgcccgcct 37500
gttccgtctg ttccgcctct tccccggtga tctccacctc ggcgtacagg gtttcgccgc 37560
tgcgccaagc ggcgcgcagg ccgcggaatg ccgggccgta gatgtagccg atctcggcga 37620
gccgctcgta gaacccggtg acatcgacag gttgcgcctc cggcggcggc cacgcggacg 37680
ggtagcccgc tgcgatgtct ccgtctccgt ttccggcacg gctgagggtg ccggtggcgt 37740
ggcgggtcca ggtgtgggtt ccttcggggc gtgcgtggat ggtgaggggg tggtgtcctg 37800
tggtgtcggg tgggtcgatg gtgagggtga ggtcgacggc ggtggtggcg gggagggtga 37860
ggggggtttc gatgacgagt tcgtcgatgg tgtcgcagcc ggtttcgtct ccggcgcgta 37920
cggcgagttc gaggaaggcg gtgccgggga gcaggacggt gtcctggatg gtgtggtcgg 37980
cgagccaggg gtgggtgcgt agggagatgc ggccggtgag gacggtgccg tcggtggtgg 38040
gcagtgcggt ggtggcggcc agcatggggt gggcggtgtc ggtgaggccg ggggtggtgg 38100
tggcctcgat ccagtaacgc ttgtggtcga aggggtaggt gggcaggtcc agcagccggg 38160
ccgtgggggt gacgggggcg atgagggtgg tccagtcgac gggtgcgccc tgggtccagg 38220
cctcggccag ggcggtgacg aagcggggat ggccgccgtc cccggtacgc agggacgcga 38280
cggtgtgcgg ctggtcgagg gcgggcagca ggaccgggtg ggcactgcat tcgagaaaca 38340
gggaaccgtc cagttccctg acggcggtgt ccatcgccac cggccgacgc agattgcgat 38400
accagtaacc gtcctcgacg ggttcactga tccagccgct gtcgagggtc gaccaccacg 38460
ggatcgtcgg ggcctgggcg ctcaccccct ccagggcctc ggcgagttcg tcctcgatcg 38520
cctccacgtg cggagtgtgc gaggcatagt ccaccgcgat ccgccgcacc cgcaccccgt 38580
catgctcgta ccgggccaga acctgctcca ccgcctccgg atcccccgcg atcacggtgg 38640
aggcgggccc gttacgggcc gcgatccaca ccccctccac cgtctccacc tcggcggcgg 38700
gcacggcgat ggacgccatc gcgccgtgac cggcgagacg ggcggcgatg ctccggctgc 38760
ggcgggccac gatccgtgcc ccgtcctcca gggtgagggc ccccgccacg cacgcggcgg 38820
cgatctcccc ctgcgaatgc cccaccaccg catccggcac caccccgtgc gcccgccaca 38880
gcgcggccag actcaccgcc accgcccacg acgccggctg caacacctcc acccgctcca 38940
acacttcggg cccggacagc atgtcccgca catcccagcc cgtgaacggc tccaaagccg 39000
ccgcacactc ggccatccgg gccgcgaaca cctccgaggc ggacatcaac gccacaccca 39060
tacccaccca ctgcgaaccc tgccccggaa acacgaacac cgtccgcaac ccgtccaccg 39120
ccaccccggt gacacggctc tccccgagca gtaccgcacg atgaccgaac accgcacgcc 39180
cccgcaccag accatccgcc accccaccga ggcccccacc cacggacgac ccgccccgca 39240
catacacatc cagccgctcc accagcgacg ccagactcga ttccgtacga gccgacaccg 39300
gcaacggcac caaccccgac accgcacctt catccggcga ggtccgccca cccggaggca 39360
gctcaggcac cccctccaaa atcacatgcg cattggtgcc gctcaccccg aacgacgaca 39420
cccccgcccg gcgcgaacgc cccgaccccg gccacggcct cgcctccgtc aacagctcaa 39480
ccgcccccgc cgaccagtcc acatgcgacg acggctcatc cacatgcaac gtccgcggca 39540
ccaccccgta ccgcatcgcc atcaccatct tgatcacacc agccacaccc gccgccgcct 39600
gggtatggcc gacgttcgac ttgaccgagc cgagcagcag cgggacttca cgaccctgcc 39660
cgtacgtcgc caaaaccgcc tgcgcctcga tcggatcacc caggaccgtc cccgtcccat 39720
gcgcctccac cacatccacg tcgccgccgc tcagtccggc gttcgccagg gcctgcctga 39780
tcacgcgctg ctgtgcgaca ccgttgggcg cggagagacc gttggacgcg ccgtcctggt 39840
tcacggccga gccacgtacg accgcgagga cggtgtggcc gttgcgttcc gcgtcggata 39900
gccgttccag gacgaggaca ccgacgcctt ctgcgaaccc tgtgccgtcc gccgagtcgg 39960
cgaacgcctt gcaccggccg tccggggcga gcccccgctg cctggagaac tccacaaagc 40020
tctgcggcgt cgccatcacc gtgacgccac cggccagcgc gagcgagcac tcccccgagc 40080
gcagcgcctg cgctgcctgg tgcagggcga ccagcgacga cgagcacgcc gtgtcgaccg 40140
tgacggccgg gccctggagc ccgtagaagt acgagaggcg ccccgacagg acgctcgtct 40200
gggtcgccgt gacgccgaga ccgcccagat cgcggccggt gccgtacccc tgatggaacg 40260
cgcccatgaa cacgccggtg tcgctctccc tgagcgtgtc cggcacgatc cccgcgcact 40320
cgaaggcttc ccaagaagtc tccagtacca gccgctgctg cggatccatg gccagtgcct 40380
cgttcgggct gatcccgaag aacgcggcgt cgaacccggc tgcctcggcg aggaacccac 40440
cgtggcgggt ggtggaccgg cctgccttgt ccgggtccgg gtcgaccagc gcgtcgacgt 40500
cccagcctcg gtcgccgggg aactcggtga tcgcgtccgt gccggaggcc acgaggtgcc 40560
acagttcctc cggcgaggag acgccgtccg gcaaccggca ggccatgccg acgatcgcga 40620
ccggttctcc tgagtcgacg gtggcgcggg ctgcgggcgc cgccgccgcg gagcctgcga 40680
ggtgcgcggc gaacgaacgc ggcgtgggat ggtcgaacgc ggtggacgcc ggaacgcgcg 40740
cgccgatccg cgaggccacg atgttcgcga attcgacggt ggtgagcgag tcgagaccgt 40800
tctcacggaa cgtacggtcc ggcgcgcagt gttcggcgcc cggcagaccg aggacggtgg 40860
caaggctgtc gcggaccagg ccgagcatca ccgtctcccg gtcggcgtcg gccgccgcga 40920
ggcggctcgc ccactccggt cccccggcgc cgggcctgac ctgacccgcc ggccctgccg 40980
gtccagccgg tccggtgagg ccggccgggc cggtgagccg ggtcaggatc ggcggtgtcg 41040
cgcccgccat cgcctcggcc cgtgccccgg aggaatcggg ccgggtgacg acgtacgagc 41100
cgccgccctc gatggccttt tccagcaact cgctggtcag agctgcctgt tcgatgccgg 41160
gcagcccatg gaccgtgacg atcgggagcc cctccgaggc tcgggacctg gcatacgcgt 41220
cggcagcggc cggatcgccg agcagcacat gtacgagtgc gctcgcgttc ccgcgctcct 41280
cggtctcggg ctcccccgtg accgctgtgg cctcagcgtc ttcggtggct cccgccactc 41340
ccccggctcc ctcagccccc gcggcccccg cggcttccgc gaccccggtg gcgacgtgtc 41400
cgaggcccgt ctcctcgcgg agcaggtcgg cgacggcgtc ggcgccatcg cccgtgacca 41460
ggatcgacga ccgcgggccg agcggctgcg gcacggtgag gaccatcttg ccggtgtgcc 41520
tggcctggct catccacgcg aacgcgtccc gcgcgcggcg gatgtcccac ggccgtaccg 41580
gcagcgggcg cagctcgtcg ccgtcgaaga gtccgaggag cagatctagg atgtcccgca 41640
gccgcgcggg gtcgacgtcg gacaggtcga agggctgctg aacgtcgtgg cggatgtcgg 41700
tctttcccat ttcgacgaac cggccgccgg gcgcgagcag ggcgacggag gcatcgagca 41760
ggtcaccggt gagggagttg agtacgacgt cgaccggggg gaacacgtcg gcgaacccgg 41820
tggtgcggga gttcgccacg tggtcggtgt cgaagccgtc ggcgtacagc aggtgctgtt 41880
tggcggggct cgcggtggcg tacacctcgg cgccgagatg gcgggcgatc cgggtggcgg 41940
ccatacccac gccgcccgtc gccgcgtgga tcagaacctt ctggcccggc cgcacggcgc 42000
ccgcgtcgac aaggccgtac cacgccgtcg cgaacacgat gggcacggag gcggcgaccg 42060
ggaacgacca gccgcgcggc gctcgcgcga ccagcctccg gtccgctacg acgctgcgac 42120
ggaacgcgtc ccgcacgaga ccgaacacgc ggtcgcctgg cgccaggtct tcgacgccgg 42180
gcccgacctc ggtcacgatc cccgcggcct ccccacccat ctcgccgtcg cccgggtagg 42240
tgccgagcgc gatcagtacg tcgcggaagt tcagccccgc ggcgtggaca tccacgcgga 42300
cctcgccgac ggccaggggg cgcggcgcgg cgtcagacgc ggtgcccagc ggggcgacgg 42360
ccaggtcgcg gagcgcgccg gatgccggtg ggcgcagcgc ccaccgcgcg gtcggcaggg 42420
gggtggtgtc cgctggtacc agtcggggca cgtaggccac cccggcccgt agcgcgacct 42480
ggggttcccc gagcgacgcc gcggcggcga cgcgctccgc gccgccatcg ccatcgccac 42540
cgccatcgcc accgccaccg ccaccgccat cgccatcgcc atcgtgaccg tcgctgccgt 42600
cgccgtccgt gtccaccagt acgaacgaac cgggctcggc cgcctgtcgc ctgagcgctt 42660
cgtcccacag cgctgcctgg tccgcgtccg gcacctcggc cgggccgacc ccgatcgcgc 42720
ggcgggtgac caccgtccgg ccctgggaaa cggtgccggg caggtcgcgc agctccggca 42780
ccgtgtcggg caggtcgcgc cgctcccaga tcacctcgca cagtgtcgcc tcgccgctgc 42840
cggtggcgac gaggcgggca ggcagcgccg cgagctcccc tcggcgcacc ttgcctgacg 42900
cggtgcgcgg gaccgtggtg acgtgcagga tttcgtcggg caccttgaag taggagagtt 42960
ggctgcggca ctccgcgagg atcgcctcgg ccgggaccct gggaccttcc ggcacgacgt 43020
agagcacggg tatctcgccg aggacggggt gcgggcgtcc cgcggcggcg gcgtccctga 43080
ctcctggcac ctcctgggcc acggactcga tctcccgtgg gtggatgttc tccccgccgc 43140
ggatgatgag ttccttgacg cggcccgtga tcgtcacatg cccggtctcc gcctggcgtg 43200
ccaaatctcc ggtgcggtac cagccgtcca ccagcacctg ggcggtcgcc tcggcctgcg 43260
cgtggtatcc gagcatgagg ctcggcccgc tcgcccacag ctcgccctcg tcgccgcgcg 43320
ccacgtcggc gcctgacacc ggatcgacga agcggagcga caggccgggc accggcagcc 43380
cgcacgagcc ggggacccgc gcgtcggtca gggtgttggc ggtgagtgag ccggtcgtct 43440
ctgtgcagcc gtaggtgtcg agcagcggca cgccgaacgc ggcttcgaac cccgccgtga 43500
gcgacgccgg cgaggtggag cccgcgacca gtgccacgcg caacgcgcgg gtctccgccc 43560
caccggagac ggcccccgtc ccaccggaga cggccccggt cccggtcccg cccgagacgc 43620
cgccggcctc accggagacg gctccgagga ggtagcggta catcgtcggc acgccgacaa 43680
gcacggtgca cgggtgttcg gccagggcgt cgagtacgtc acgcgcgacg aagccgccga 43740
ggatgcgggc cgacgcgccg acggtgagga ccgcgagcag gcagaggtgg tggccgagac 43800
tgtggaacag cggcgccggc cacagcagtt cgtcgtcctc ggtgagctgc caggacggca 43860
cgtcacagta cttcgcggac cacaggccgc tgcgctgcgc ggagacgacg cccttcgggc 43920
gccccgtggt cccggacgtg tagagcatcc aggcgggttc gtccaggccg aggtcgtcgc 43980
agggcgggca cggcggttcg gttccggcca ggtcctcgta cgcgatacag ccctgttccc 44040
gccgaccggc cagcacgacg gtggcgcggg tgccgacgcg ccgtacctgg tcgaggtgga 44100
ggtcgtcggt gaccagcacg gtcgcgccgg agtccgacag gaagtgggcc agctcggcgt 44160
cgccggcgtc ggggttgagc ggcaccgcga cggcggcggc gcgcgcggcg gcgagatagg 44220
cctcgatcgt ctcgatccgg ttgccgagca gcagcgcgac gcggtcgccg cggcccacgc 44280
cggacgcggt gaggtgtccg gctatccggc cggagcggat gtggagctgc gcgtacgtca 44340
cggcgcgtcg ggaatccgtg taggcgaccc ggtcgccgcg ccgttcggaa ttcacgcgga 44400
gcagttcgtg cagaggccgg atcgattccg cacgcgccat ggaaacacct ttctgtctgc 44460
tgttcgcacg gcagcacgaa gccgagcacc agcgaatggc ggcgacgcta acagcgattc 44520
cctgacgatc caccccctga ccatccccct gccttggccg gacgccctgt catatgtcta 44580
gggggttgca cgaataccgt cgcgcgtact tttctgccct gtgaccgacc acgggacgac 44640
cgaccacgga acggcaggga gggtggggct ttgtctgcgc ctgtcgcggc accgtactgc 44700
cgcttcgaga agatcggatc gccggatctc gacggcgacg agacggtgct cggcgtcatc 44760
gagcacggca caggacacac cggggcgtcg ctggtggacg gcgtcccgcg gaccgcggtg 44820
cacaccacga cccgcgacga gcaggcgttc gccgaggtct ggcacgcacc gggccccgtg 44880
gagtccggta cggacgacgg catcgcgtgg gcccgcaccg gcgagtacct gttcggggtc 44940
ggccgcgtcc acgagagcgg caggtacgcc gacgccgtat cggcgctcta cacgcggatc 45000
ttcgggctga cccgatcgct ggggcgcccg ctgctcgccc ggacgtggaa ctacatcagc 45060
ggcatcaact cggccaacgc ggacggcctg gaggtgtaca gggacttctg cgtcggccgt 45120
ggccaggcgc tcgacgggct cggggtcgac ccggccggca tgcccgcggc caccggcatc 45180
ggcgcgcacg ggggcggtat cgcctgcgtg ttcatcgccg cccgcggcgg ggtcagggtc 45240
aacatcgaga accccgcggt cctcacggcc caccactacc cggcggcgta cggcccgcac 45300
ccccctgtct tcgcacgggc cacctggctg ggcccggggg aagaaggtgg ccggctgttc 45360
gtctcggcga cggccggcat cctcggacac gagacgacgc accacggtga cgtgaccggc 45420
cagtgcgaag tcgccctgga caacatcgcc cgggtggtcg gcgcggagaa tctgcgccgc 45480
cacggcgtcc cacgaggaca cgtcctcgcc gacgtcgatc acctcaaggt ctacgtgcgc 45540
cgtcgcgagg atctcgcggc ggtccgccgg gtctgcgccg cgcgcctgtc gagcacggcg 45600
accgtcgcgg ttctgcacac cgacatcgcc cgcggtgacc tgctcgtcga aatcgagggg 45660
gtggtgcggt gacaccggag ggaaaaaggc caggcactct gcgtcttggc ggctccgcga 45720
agaatcgggg gaaaagggat ggagctgcga aggatcccga gacagagaat ctcgggacgg 45780
agaaccgggg agcggagaac cgggggacgg agaacccggg ggcaaatagg cgaggggtga 45840
agaatcgcga gaagaagaat caggaaatcg tcgccgccga ccgcgccgag ccgttagtct 45900
cctccttctc ccagcgtcga atctggttcc tgcaacaatt ggacccggac agcaacgcct 45960
acaatctgcc gctcgtacgg cgtctgaggg ggccgcttga cgcggcgctt ctggagcgcg 46020
cgctcacgct cgtcgtggcg cggcacgagg cgttgcggac ggtgttcgac gcctcggacg 46080
gggaccccgt ccagcgggtg cttcccgccc cgacccggat tctgcgccac gcgcgggccg 46140
acggagagca gggcgcggga tcgctcgtgc gcgcggagat cgccgcgccc ttcactctct 46200
ccaccgggcc actgatcagg gctctgctga tccgtatcgg tgacgacgac catgtcctcg 46260
cggtgaccgt gcaccatgtc gcgggcgacg gctggtcgtt cgggctgctc caactcgaac 46320
tcgccgcgca ctacgcggcg ctccgcgaca ctgccgcgcc cgccgtgctg ccgccgttgc 46380
cactccagta cgccgacttc gccgcttggg aacggcgtga gctggcaggg gccgggctcg 46440
aaaagcgcct ggcctactgg cgtgaacggc tcaagggcgc cccgccggtg ctcgatctgc 46500
ccaccgaccg tccccgccca cccgtggccg acgcggacgc ggggctggtc gaatggcgtc 46560
cccccgccgc actggccacg gccgttctcc aactcggacg cggcgcgggc acctccgtgt 46620
tcatgaccct gctctcggcg ttccagctcg tcctcgcccg gcaggccggc acacaggacg 46680
tactggtcgg cacgcccgtc gcgaaccgta cgcgaaccgc gttcgagggc ctcatcggca 46740
tgttcgtcaa cacactcgtg ctccgcggcg acctctcggg cgacccgacg ttccggcagc 46800
tcctcgaccg ctgccgggcc acgaccgccg acgcgttcac ccacgccgac ctgccgttcg 46860
agaacctgat cgaggtcgtc gcacccgacc gcgacctgtc ggtcaacccc gtcgtacagg 46920
tgctgctaca ggtactgcgg cgcgacgcga cgacggccgc actgccaggc gtcacgtccg 46980
agccgttcgg caccggccgc tggttcaccc ggttcgacct ggagttccat gtgtacgagg 47040
agtcggacgg cgtcctcacc ggtgaactcc tctacagtcg ggcgctgttc gacgcttcga 47100
ggatcacgcg gttactggac gagttcacgg ccgtgctggg ggccgccacc gccgacccgg 47160
gcacacggct ctcccagctg cccgtcggcg gcgccgcgac gagtgcccgc ctcccctcga 47220
acgacacggc acgggaactg cccgtcgaga cgctgccgga gttgctggcc aggtacgccg 47280
cgagaacccc cgacgccgtg gctgtcacgg acccgcggac ctcgctcacg tacacggagt 47340
tggaccggcg ggcgaaccgc ctcgcgcacc tgctccgggc acgcggtacc gccaccggcg 47400
acctcgtcgg gatctgcgcc gaccgaggcg tcgacctgat cgtcggcatc gtggggatcc 47460
tcaaggcggg cgccgcgtac gtaccgctcg atcccgaaca cccccaggaa cgcacggctt 47520
tcgtccttga cgacgcgcgg ctgaccacgg tggtgacgca cgaggcctac cgtgcccggt 47580
tctccgccgg gccccggggg ctctcggctg tgccacaggg gacctccgcc gtgccacagg 47640
agtcctccgc cgtgtcacag gagtcctccg ccgtgtcaca gggggccttc cccgtaccgc 47700
acgtggtgac gctcgacgcc ccggacctcg accgccggcc ggacactccg ccgcacatca 47760
cgctcgaccg ggacagcctc gcctacgcga tctacacatc cgggtcgacc ggcaggccca 47820
aggccgtgct catgccgggc gtcagcgccg tcaacctgct gctctggcag gaacgcacga 47880
tggggcgcga ggcggacagc cgcaccgtcc agttcgtgac cgccaccttc gactactcgg 47940
tgcaggagat attctccgcc ctgctcggcg gcacactcgt catcccaccc gacgaggcac 48000
ggttcgaccc cccgggcctg gcccgctgga tggacgagca gcggatcacg cggatctacg 48060
cgcccacggc cgtgctgcgc gcgctggtcg aacacgtcga tccggacagc gatcagctct 48120
ccgcgctccg gcacctctgc caaggtggtg aggccctgat cctcgacgcg cggctgcgtg 48180
aactctgccg ccaccggccc catttgcgcg tccacaacca ctacggcccg gccgagagcc 48240
aactcgtcac cgggtacacc ctgccggccg accccgacac gtggccgtcc gcggcaccga 48300
tcggcccgcc gatcgacaac acccgcatcc atcttctcga cgacgcgctg cggccggttc 48360
ctgacggcgt gccggggcag ctctgcgtcg ccggcatcgg tctggcccgc ggatacctcg 48420
cccgccccga actgaccgcc gagcgatggg tggcgggcgg cgtcaccggc gaggagcgtc 48480
tgtatctcac cggggacctg gcgcgccgcg cgccctccgg cgacctggac ttcctcggcc 48540
ggatcgacga ccaggtcaag atccgcggca tccgcatcga gcctggtgag atcgagagcg 48600
tgctcaccga ggactcccgc gtcgcacacg ccgccgtctc cgtacgcgag gatccgcggg 48660
gcgagaagtt cctggccgcg tacgtggtgc cgaccggcgg cccacatgcc gtcccgtcca 48720
ccggcccgca cgccgcgccg tccaccggcc cacgcgccgt cccgtccacc ggcccgcacg 48780
ccgcgccgac cggccccccg catgcctcgc ccaccgcagg tcagcgcgtc ggcggcctcg 48840
ccacctcgcc gcgtgaagac ctcgccactt cgctgcgtgc aggtctcgcc gcccggttgc 48900
ccgcctatct cgtgccgtcg tccgtcaccc tggtggacgc gctgcccagg accacgagcg 48960
gcaaggtgga ccggcgggcg ctgcccgagc cggagcccgt cccggcgtcg gccgggaaga 49020
ccgcgccccg cactcgcgcc gagcgcgcgg tgtgccggac cttccaggac gtgctcggcg 49080
tccctgaggt cggtaccgac gacgatttct tcgcactcgg cgggcattcc ctgctcgcca 49140
cacgggtcat cgcgcggctc cgcgcccagc tcggcgccga cgtcccgctg cgcacgctct 49200
tcgacgcgcg gacacccgcc gcgctcgccc gcgcggtgga cgcggcaggg cccgccgccc 49260
tgcccccggt cctgccctca cccggcgacg gtcccgtgcc catcaccgcg gcgcaggaac 49320
agatgctgca ctcgcacggc tcgctgctcg ccgcgccttc ctacacggtc gcaccgtacg 49380
ggttccggct gcgcgggccg ctcgaccgcg acgcgctgga cgcggcgctg acccggatca 49440
ccgcgcggca cgagccgttg cgcacggggt tccggggccg ggatcagatc gtccggccac 49500
ccgctgcggt gcgcgccgaa gtggtcgagg tgccgtccgg tgatgtccgc gccgcggtcc 49560
tggtcgcccg cgcggagttg accaggccct tcgacctcgt ggacgggccg ttgctgcgtg 49620
ccgtgctcct gccgctcggc gcggaggatc acgtactgct gctgatgttg caccatctcg 49680
ccggtgacgg ctggtcgttc gatctcctgg tcagggaggt gtccgggggc tcaccgcagc 49740
tgccggtctc ctacacggac gtggcccgat gggagcggac cccggccgtg gtcgccgcac 49800
gggaagccga ccgggcgtac tggcgcggcg agttggcggg cgccgccgct ccggagctgc 49860
ccgcggtcgg gccccgctcc acgaccgcgc cggccgggcg ggcattcctc tggacgctcg 49920
acggtgccac ggtcgatgcg gcacgcctgg tcgccgaggc cgggaacgcc acgttgcacg 49980
agaccgtgct cggcgccttc gccctggtcg tggcggaggc cgccgacacc gatgacgtac 50040
tcgtcgcgac accgttcgcg gaccggggga acgccgggac cgaccacctc atcggcttct 50100
tcgcgaaggt gctcgcactg cgcatcgacg tcggcagcga caacagcggc ggcgacagac 50160
accaccacag gcacaccaag agcgacagcg acagccgcga tgacaacagc ggcacaccgt 50220
cgttccccga ggtcctgcgg cgggtgcgct ccgcgatggc aggcgcccac gcccatcagt 50280
ccgtccccta ctcggcgatg cgcgcggcgg accccacgct gccgcccgcc cccgtgtcgt 50340
tccagctcat cagcgcgctc agcacggaac tgcggctgcc gggactgcgt accgaaccgt 50400
ttcccgtcgt cgcggagacc gtcgacgaga tcgacggcga actgtcgatc aatctcttcg 50460
acgacggtcg caccgtctcg ggcgcggtcg tccacgacgc cgcgctgctc gaccgcgcga 50520
ccgtcgacaa cctgctcacc cgggtggagt cgacgctgcg caccgccgcg ggcgacctca 50580
ccgtacgcgt caccggtcaa gtgggaagcg agtaaccgtg cccgaacagg acaagacggt 50640
cgagtacctt cgctgggcga cctcggaact gcagaggacg cgggcggaac tcgccgcgcg 50700
cagcgagccc ttggcggtcg tgggcatggc ctgccggctg cccggcgggg tcgcgtcccc 50760
cgacgatctg tggcggctcc tcgactccga aggcgacggc atcggcgcct tccccgccga 50820
ccggggctgg gagaccggcg ccgacggccg gggcggattc ctgaccgggg cggccgggtt 50880
cgatgccgcg ttcttcggcg tcagcccgcg tgaggcactg gcgatggacc cgcagcagcg 50940
tgtggtcctt gagacgtcct gggaagcgct cgaacacgcg ggcatcgacc cgcacacgct 51000
gagcggcagc gacaccggag tcttcctcgg ggcgttcttc caggggtacg gaatcggcgc 51060
ggacttcgac gggtacggca ccacgagcat ccacacgagc gtgctgtcgg gccgcctctc 51120
gtacttctac ggtcttgagg gccccgcggt caccgtcgac acggcgtgtt cgtcgtcgct 51180
ggtcgccctg caccaggccg ggcagtcctt gcgctcgggc gaatgctccc tcgccctcgt 51240
cggcggggtc acggtgctgg cgtcgcccgc gggtttcgcg gacttctccg agcagggcgg 51300
gctggcgcag gacggccggt gcaaggcgtt cgccgaggcg gcggacggta ccgccttcgc 51360
cgagggctcg ggcgtcctgg tcgtggaacg gctctccgac gcggagcgcc ggggccaccg 51420
gatcctcgcg gtcgtacggg gctccgccgt caatcaggac ggcgcctcca acgggctctc 51480
cgcacccaac ggcccctccc aggaacgcgt catccgccag gccctcgcca acgccggact 51540
cacccccacc gacatccatg ccgtcgaggg tcacggcaca gggacccgcc tcggcgaccc 51600
catcgaggcg accgcgctgc tcgcgacgta cggacagcag cgcaccacac ccctgctcct 51660
cggctccctc aaatccaata tcggccacac ccaggccgcc gcgggcgtcg cgggcgtcat 51720
caaaatgatc ctcgccatgc accacggcac cctgccgccc accctccacg tcgacacgcc 51780
ctcctcacac gtcgcctgga cggcgggcgc tgtcgaactc ctcaccgacg ccaggccctg 51840
gcccaccacc actggccccc accgcgccgg tgtctcctcc ttcggcgtca gcggcaccaa 51900
cgcccacgtc atcatcgaaa gccaccccca acccgcgccc gccgcccccg ataccgaacc 51960
cggcgcccgt cccgtccccc tgctcctctc ggcccgcacc cccgaagccc tcgacgcgca 52020
caccggccgc cttcgcgcgt tcctccggga caaccccggc gctgaccgtg tcgccatcgc 52080
gcagacactc gcgcgccgta ccccgttcga gcaccgtgcc gtgctgctcg gcgacacgct 52140
catcgccgct gacccgaacg cgggctcggg tccggtcgtc ttcgtctact ccgggcagag 52200
caccctccac ccgcacaccg gacgccaact cgccaccacc taccccgtct tcgcggacgt 52260
gtgggacgag gtcctcggcc atctcgaccc cgaccagggg cctgccacgc acttcgccca 52320
ccagaccgcg ctcaccgcgc tgctgcggtc ctggggcatc accccgcacg cggtcatcgg 52380
ccactccctc ggcgagatca ccgccgcgtg cacggccggt gttctgtccc tcggtgacgc 52440
gagcgcgctc ctggccgccc gcagccgcct catggacaaa ctccccacgg gcggcgccat 52500
ggtcaccgtc ctgacgagcg aggagcacgc tctgggggcg ctgcggcccg gggtggagat 52560
cgccgccgtc aacggcccgc actccgtcgt actctccggc gacgaggacg ccgtgctcga 52620
cgtcgcgcgg cagctcggca tccaccaccg cctgccgacc cgccacgcgg gccactccgc 52680
acgcatggaa ccgctcgtcg ctcccctgct ggaagccgcg cggaagttga cgtaccacca 52740
gccgcgcgtc gccgtccccg gtgatcccac caccgccgaa tactgggcgc gccaagtccg 52800
tgaccaggtg cggtttcagg cacacaccga gcggtatccg ggcgccacgt tcctggagat 52860
cgggcccaat caggatctct cccccgtcat cgacggcatt cccacccaga ccggtgtgcc 52920
cgacgaggtg cgggcgctgc acaccgccct cgcgcacctg tacatccgtg gcgtcgcgat 52980
cgactgggcg gccgttctcg gcggggaccg cgcgcccgtc gcgctgccca cctacccgtt 53040
ccagcacaag gactactggc tgcgggccac cgtccgggcg gatgtgaccg gcgcggggca 53100
ggagaaggtg gcgcacccgc tgctcggcgc gtcggtcgcg ctgcccggtt cgggcggaac 53160
cgtactgacc ggccgtgtct cgctcgcctc ccacccgtgg ctcgccgggc acgctgtcaa 53220
cggcgccgtg ctcctgccgg gtgcggcctt cctcgaactc gcggtgcgcg ccggtgacga 53280
ggccggatgc gacctgctcc acgaactcgt cgtcgagacc ccgctcgcgt tgccggcgac 53340
gggcgccgtg gcgatctccg tggaggtcgc cgaggccgac gacgcggggc ggcgggcgct 53400
caccgtgcac gcgcgggtcg aaggcggggg actgtggacc cgccacgcca ccggctccct 53460
cggcaaggcc gcctcgaccg gcgccgcgac ggacccggct ccttggccgc ccgccggggc 53520
cctgccggtc gaggtcggcg atgtgtacga gcggttcggg ggcgtcggct acgcgtacgg 53580
gccctcgttc caggggttgc gggccgcgtg gcgcgacgga gacaccgtcc acgccgaggt 53640
ggcgctgccc gaagagctga gtgcggacgc cgcccggttc acgctgcatc ccgcgctgct 53700
cgacgccgcg ttccaggcgg gggcgctgcc cgcactcgac gcgcccggcg aggcggcccg 53760
gctgccgttc gcgttccagg acgtccggat cttcgcggcc ggggcgacgc gggcgcgggt 53820
cacggtcggc cgcgaagggg atcgcggcac cgtgacgatg accggcgagg acggacagcc 53880
ggtggcggtg gtgggttctg tggtgtcgcg cccgcacacg ggcggtaccg gcacgggcac 53940
gggctccgac ggtctgctgc gcccggtatg gaccgagctg ccgatgcccg ctccgtccgc 54000
gagcgacccg cgcgtggagg tcttcggcgc ggaccccgtg gacggtgaac ccgtgtcggc 54060
gactagggag ttggccggtc gcgtcctcgg cgcccttcag cggcggctgt ccgccaccga 54120
tgacgtgacc ctggtcgtac gggtcagcac cggtctcgct gcttccgccg ccgcgggcct 54180
ggtgcgctcc gcgcaggcgg agaaccccgg cggtgtcgta ctcgtggagg cgccccccga 54240
gacccccacc gacctgctgg ccgcctgcgc cgcgttggaa gaaccgtggt tggccgtcag 54300
ggacggtgtg ctccacgcgc cgcgtctggt gcggatgtcc gaccccgtgc acggcccact 54360
gccgctgccg gacggcgact ggctgctcac ccgctccgcc tccggcgttc tgcacgacgt 54420
cgcactcacc gccgacggtg cgccccgcag ggcactcgaa gccggtgagg tccgcgtcgg 54480
cgtccgggcc gcgggcctga acttccgcga tgtgctgatc gcgctcggga cgtacgacgg 54540
ggccacgacc atgggcggcg aggcggcggg cgtcgtcgtg gagaccgggc ccggtgtggc 54600
cgacctgtcc ccgggcgacc gggtgttcgg cctgacgcgg ggcggcatcg ggccgacggc 54660
cgtcaccgat cggcgttggc tggccaggat tcccgacggg tggagcttca ccacggcggc 54720
gtccgtcccg atcgtcttcg cgaccgcgtg gtacggcctg gtcgacctgg cgggagtacg 54780
cgagggcgag aaggtactcg tgcacgcggg caccggcggt gtgggcatgg ccgccacgcg 54840
gatcgcccgc catctcggcg ccgaggtcta cgccaccgcc ggcacgggga aacagcacgt 54900
gctgcgcgcc tcggggctgc ccgacacaca catcgccgac tcgcggacga ccgcgttcag 54960
gaccgccttc ccgcgtatgg atgtcgtcct gaactcactg accggtgagt tcatcgacgc 55020
gtctctcgaa ctcctcgacg caggcggccg attcgtggag atgggccgcg ccgagctgcg 55080
cgacccggcc acgatcatcc ccgcctacct gcccttcgat ctcatggacg cgggcaccga 55140
ccgcataggc gagatcctgg gcgagttact gacgctcttc gacacgggag ccctcagccc 55200
gctgccggtc cgcgcctggg acgtccggca ggcacgtgag gcgctcggct ggatgagccg 55260
cgcccgtcac atcggcaaga acgtcctcac cctcccccgg ccgctcgacc cggagggcgc 55320
ggtcgtcatc acgggcggct ccggcacact cgccggtatc ctcgcgcgtc atttgagcgg 55380
gctccacgtc tacctgctgt ccaggacggc gccgcccgag gacacgccgg gcacccatct 55440
gtcctgcgac gtcggcgacc gggcccaact ggcctcggcc ctgtcgcgga tcgaccggcc 55500
gatcacagcc gtggtgcaca ccgcgggcgt cctggacgac gggaccgtcc cttccctcac 55560
gcccgagcgt ctggacaccg tgctgcgccc gaaggccgac ggggcctggc acctgcacca 55620
gctcaccgag gaccaggacc tcgccgcctt cgtgctctac tcctcggccg caggcgtgct 55680
cggcaacgcg ggccagggca actatgtcgc ggccaacgcg ttcctcgacg cgctcgccga 55740
gctgcgccac gcggccggcc tgcccgcgct ctccatcggc tgggggctct gggaggacgc 55800
gagtgggctc accgccgcac tgagcgaggc ggacagggac cggatgcggc ggagcggatt 55860
ccgtacgatc accgcgcccc acggcatgcg gctgttcgag gcggcgaggc gcaccggtac 55920
tcccgtggtg gtggcggccg agctcgacga cgcgccggac gtgccgctgc tgcgtgggct 55980
tcggcgtacg actgtgcggc gcgccaccgt acgggagcgt tctctcgccg accggctcgc 56040
cgcactgtcc gacgacgagc gcgccgacgc gctcctcgcg ctcgtcaggg acagcaccgc 56100
caccgtcctc ggccacctgg gcgccgagga gatccccggg acgacgacct tcaaggaact 56160
cggcatcgac tcgctcaccg cggtccagct gcgcaacacg ctgaccacgg cgaccggggt 56220
acgcctcaac gccacggcgg tcttcgactt cccgacgcca cgcgcgctcg ccgtcaggct 56280
cggcggtgag ctgaccggta tccacgcgcc cgtggcggcc aggaccgcgg ccacggcggt 56340
cgcgcacgac gagccactgg cgatcgtggg catggcctgc cggctgcccg gcggggtcgc 56400
gtcccccgac gatctgtggc ggctcgtcgc gtcgggcacc gacgccatca cggagttccc 56460
caccgaccgg ggctgggacg tggacgcgct ctacgacccc gaccccgacg cgatcggcaa 56520
gaccttcgtc aaacacggcg gcttcctcga cggcgcgacc ggcttcgacg cgtcgttctt 56580
cgggatcagc ccgcgcgagg ccctggccat ggacccgcag cagcgggtgc tcctcgaaac 56640
gtcgtgggag gcgttcgaaa gcgccgggat caccccggag tcggccaggg gcagcgacac 56700
cggcgtgttc atcggcgcgt tctcgtacgg gtacggcgcg ggcgcggaca ccaacggttt 56760
cggcgcgacc ggctcgcaga ccagcgtcct ctccggcagg ctctcctact tctacggcct 56820
ggaggggccg tcggtcacgg tcgacacggc gtgctcgtcg tcgctggtcg ccctgcacca 56880
ggccgggcag tccttgcgct cgggcgaatg ctccctcgcc ctggtcggcg gcgtcaccgt 56940
gatggcgtcc cccggcggct tcgtcgagtt ctcccgtcag cgcggtctcg cccccgacgg 57000
gcgggctaag gcgttcggcg cgggcgcgga cggtacgagc ttcagcgagg gggccggcgc 57060
cctgatcgta aaacggctct ccgacgcgga gcgcgacggg cacaccgtcc tcgctgtcgt 57120
acggggctcc gcggtcaact ccgacggggc gtcgaacggt ctgtcggcgc cgaacggtcc 57180
tgcgcaggaa cgcgtcatcc gccaggcgct cgccaacgcg ggactcacca ccgccgatgt 57240
cgacgcggtc gaggcgcacg gcacaggcac ccgcctgggg gaccccatag aggcgcaggc 57300
gctgctcgcg acgtacgggc aggaccgggc gacgcccctg ctgctcggct cgctgaagtc 57360
gaacatcggg cacgcccagg ccgcgtcagg tgtcgcgggg atcatcaaga cggtgcaggc 57420
catccggcac ggggaactgc cgccgaccct gcacgcggac gaaccgtcac cgcacgtcga 57480
ctggacgtcc ggcgccgtcg aactgctgac atcggccagg ccgtggccgc ggaccggccg 57540
tccgcgccgt gcggcggtct cgtcgttcgg ggtgagcggc accaacgccc acatcatcct 57600
ggaggccgga cccgaccagg aggagccgtc ggcagaaccg gccggtgacc tcccgctgct 57660
cgtgtcggca cggtccccgg aggcactgga cgagcagatc gggcgcctgc gcgactatct 57720
cgacgccgcc cccggcgtgg acctggcggc cgtggcgcgg acactggcca cgcgtacgca 57780
cttctcccac cgcgccgtac tgctcggtga caccgtcatc accgctcccc ccgtggaaca 57840
gccgggcgag ctcgtcttcg tctactcggg acagggcacc cagcatcccg cgatgggtga 57900
gcggctcgcc gcagccttcc ccgtgttcgc cgagacctgg cacgacgcgc tgcgccggct 57960
cggcgacccc gacccgcacg accccacaca cagccagcac acgctcttcg cccatcaggc 58020
ggcgttcacc gccctcctgc ggtcctgggc cgtcacgccg gacgccgtca tcggacactc 58080
gctcggcgag atcaccgccg cgtacgccgc gggcgtcctg tcgctcggcg acgcctgcac 58140
cctcgtcacc acgcgcgccc gcctcatgca cacgctcccg ccgcccggag ccatggtcac 58200
cgtgctgacc agcgaggacg aggcccgtca cgccctgcgg accggcgtgg agatcgccgc 58260
ggtcaacggc ccccactccg tggtgctctc cggcgacgag gacgccgtac tcgccgtcgc 58320
acaggggctc ggcatccacc accggctgcc cgcgccgcac gcgggtcact cctcgcacat 58380
ggagcccgtg gccgccgagc tgctcgccac cacccgcggg ctcacttacg gccggcccca 58440
caccgccatc ccgaacgatc cgaccaccgc cgagtactgg gccgagcagg tccgcgagcc 58500
ggtgttgttc cacgcccacg cacagcggta tcccgacgcc ctgttcgtcg agatcggccc 58560
ggggcaggac ctcgccccgc tggtcgacgg cgtcgccctg cagaacggca cggcggacga 58620
ggtgcacgcg ctgcacaccg cgctcgcccg cctgtacacg cgcggcgcca cgctcgactg 58680
gccccgcatc ctcggcggca cggcacggca cgacccggac gtacccgcct acgccttcca 58740
gcggcggccc tactggatcg agtccgcgcc gccggtcacg gccgacgcgg gccaccccgt 58800
actgggcaca gggatcaccc tcgccgggtc gccgggccag gtcttcacgg gccccgtgcc 58860
ggccggcgcc gaccgtgcgg tgttcgtcgc cgaactggcc ctcgccgccg cggacgccac 58920
caggtgtgcc acggtcgaac ggctcgacat cgcctccgtg ccccgcccgt ccgtcggtgg 58980
cggggtcacc gcgcaaatct gggtggatga cccctcggcc gacgggcggc gccgcttcac 59040
cgtgcacacc cgcaccggcg acgccccgtg gacgccgcac gccgaaggag tcctccgccc 59100
cggcgaggtg cccctgcccg aggccgtcga caccgcgtgg ccaccgccgg gcgcggtgcc 59160
cgccgacggg gcgcccggcg cgtggcgccg cggcgaccag gtcttcgtcg aggccgaagt 59220
ggacagcccc gacggtttcg tggcccaccc cgacctgctc gacgcggtcc tctccgcggt 59280
gggcagcgga agccgccagc cgacccgatg gcgcgacctg gcggtgcacg cgtcggacgc 59340
caccgtgctg cgcgcccgcc tcacccgccg cgcgggcggt gccgtcgaac tcgccgcctt 59400
cgacggtgcg ggtctgccgg tactcaccgc ggaggcggtg acgttgggcg aggtcgcgtc 59460
ggcaggcgaa tccgcgcggt cggacggtct gctccggatc gagtgggtgc cgttggcgga 59520
ggccgactac gacggcgacc tccccgacaa ctacaccctc atcaccgccg cacaccccga 59580
cgaccccacc gacccgaaca acacacccac ccgcacccac acccagacca cccgcgtcct 59640
caccgccctc caacaccacc tcaccaccac ccaccacacc ctcatcgtcc acaccaccac 59700
cgaccccgca ggcgccgccg tcaccggcct cacccgcacc gcccagaacg aacaccccgg 59760
ccgcatccac ctcatcgaaa caccccaccc ccacacccca ctccccctca accaactcac 59820
caccctcaac caaccccacc tacgcctcac ccaccacacc ctccacacac cccacctcac 59880
ccccctcccc accaccaccc accacacccc acccctcaac ccccaccacg ccatcctcat 59940
caccggcggc tccggcaccc tcgccggcat cctcgcccgc cacctcaacc acccccacac 60000
ctacctcctc tcccgcaccc caccaccaca caccaccccc ggcacccaca tcccctgcga 60060
catcaccgac cccacccaac tcaccaccgc cctccaccac ataccccaac ccctcaccgg 60120
catcttccac accgcaggca ccctcaacga cgccaccctc gaccaccaaa ccccccacca 60180
cctcaccacc accctccaac ccaaagccga cgccgcctgg cacctccacc acctcaccca 60240
acaccaaccc ctcacccact tcgtcctcta ctccagcgcc gccgccaccc tcggcagccc 60300
cggccaagcc aactacgccg ccgccaacgc cttcctcgac gccctcgcca cccaccgcca 60360
cacccaccac caacccgcca ccaccatcgc ctggggcatg tggcaaacca ccagcaccct 60420
cacccaacac ctcaccacca ccgaacgcga ccgcatccgc cgcggcggtt tcctgccgat 60480
ctccgacgaa gagggcatgc gtctctacga cgcggccgtc ggctcgggcg aggctttcgt 60540
catggctgcc gcgatggacc tgtcgcagcc catggcgggc gatgtaccac ccatcctgag 60600
tgggctgcgc agaagcgcgc gccgcaccgc cagggcgggg cagacgttca cgcagcggct 60660
cgccgaactg cccgcggccg accgcgacac ggcactggtc actctcgtct cggatgccac 60720
ggccaccgtg ctcggccacg ccgacgcctc agccatcgca ccgacgacga cgttcaagga 60780
cctcggcatc gactcgctca ccgcgatcga gctgcgcaac cggctcgcgg aggcgaccgg 60840
gctccggctg agcgccacga tggtgttcga ccatccgaca ccgcgggtac tcgccgccga 60900
actgcgcacc gacctgttcg gcacggccgt gcccctgccc gcccggacga cacgggcccg 60960
cgacgacgaa cccctcgcga tcgtcggcat ggcgtgccgc ctgccgggcg gcgtgacgtc 61020
acccgaggaa ctgtggcggc tcgtcgagtc aggcacggac gcgatcaccg agttccccga 61080
cgaccgaggc tgggacatcg accggatgtt cgacccggat ccggacgcac caggcaagac 61140
ctacgtcagg cacggcggtt tcctctccga ggcagccggg ttcgacgccg cgttcttcgg 61200
catcagcccg cgcgaggcgt gggccatgga cccgcagcag cgcgtcatcc tcgaaaccgt 61260
ctgggaggcg ttcgagaacg ccggaatcgt ccctgacacg ctgcgcggga gcgacaccgg 61320
cgtgttcatg ggcgcgttct cccacggata cggagccggt gtcgacctcg gcgggttcgg 61380
cgccacggcc acccagaaca gcgtgctctc cggccgcctc tcgtacttct tcggcatgga 61440
aggccctgcc gtcaccatcg acacggcctg ctcgtcgtcc atggtcgccc tgcaccaggc 61500
ggctcagtcc ctgcgggacg gcgaatgctc gctggcactc gccggcggcg tcacagtgat 61560
gcccacaccg ctggggtacg tcgagttctg ccgccaacgc ggactcgccc ccgacggccg 61620
ggccaaggcc ttcgctgagg gcgccgacgg tacgagtttc tccgaaggct ccggcgtact 61680
cgtcgtggaa cggctctccg acgccgaacg caacggtcac accgttctcg cactcgtccg 61740
ctcctccgcc gtcaaccagg acggcgcgtc caacggcatt tccgcgccca acggcccctc 61800
acagcagcgc gtgatccgcc aggcgctcga caaggcgggt ctcacccccg ccgacatcga 61860
cgtggtggag gcacacggca ccggcacccc gctcggcgac ccgatcgagg cgcaggccat 61920
catcgccacc tacggccagg accgcgacac accgctctac ctcggttcgg tcaagtcgaa 61980
catcggccac acccagacca ccgccggtct cgcgggtgtc atcaaaatgg tcatggcgat 62040
gcggcacggg gtgctcccga agacgttgca tgtggatgag ccgtcgtcgc atgtggactg 62100
gtcggcgggg gcggttgagc tgttgacgga ggcgaggccg tggccggggt cggggcgtcc 62160
gcgccgcgcg ggggtgtcat cgctcggcat cagtggcacg aacgcgcatg tgattctgga 62220
aggggtggag gggccgcctt ccggtttggg gccttcctca cccactgggg cctcctctgg 62280
tgcggagccg tccgctggtg cggagtcgtc gggtctgggg gcgggatcgc ccggtgcggg 62340
cgcagacgcg gacaggggtt tgggtccggt gccgttgccg gtgtctgctc gtacggaatc 62400
gagtctggcg tcgctggtgg agcggctgga tgcgtatgtg cggggcgggt tgtccgtggg 62460
tggggacctc ggtggggtgg cggatggtct ggtgcggggg cgtgcggtgt tcggtcaccg 62520
tgcggtgctg ctgggggaga gccgtgtcgc cggggtggcg gtggacgggt tgcggacggt 62580
gttcgtgttt ccggggcagg gttcgcagtg gacgggtatg ggtgtggagt tgatgtccgc 62640
ctcggaggtg ttcgcggccc ggatggccga gtgcgcggcg gctttggagc cgttcacggg 62700
ctgggacgtg cgggacatgc tggcggactc ggccgtgttg gagcgggtgg aggtgttgca 62760
gccggcgtcg tgggcggtgg cggtgagcct ggccgcgctg tggcgggcgc acggggtggt 62820
gccggatgcg gtggtggggc attcgcaggg agagatcgcc gccgcctgcg tggcgggggc 62880
cctcaccctg gaggacgggg cacggatcgt ggcccgccgc agccggagca tcgccgcccg 62940
tctcgccggt cacggtgcga tggcgtccat cgccctcagc gcctcggagg tcgagacccc 63000
cgagggggtg tggatcgcgg cccgtaatgg gcccgcctcc actgtgatcg cgggggagcc 63060
ggaggcggtg gagcaggttc tggcccggta cgagcatgac ggggtgcggg tgcggcggat 63120
cgcggtggac tatgcctcgc acactccgca cgtggaggcg atcgaggacg aactcgccga 63180
ggccctggag gggatcacca gtcgggcccc gacggtcccg tggtggtcga ccctcgacag 63240
cggctggatc agtgaacccg tcgaggacgg ttactggtat cgcaatctgc gctggccggt 63300
ggcgatggac accgccgtca gggaactgga cggttccctg ttcctcgaat gcagtgccca 63360
cccggtcctg ctgcccgccc tcgaccagcc gcacaccgtc gcgtccctgc gtaccgggga 63420
cggcggccat ccccgcttcg tcaccgccct ggccgaggcc tggacccagg gcgcacccgt 63480
cgactggacc accctcatca cccccgtcac tcccacggcc cggctgctgg acctgcccac 63540
ctaccccttc gaccacaagc gttactggat cgaggccacc accacccccg acctcaccgc 63600
cctcggcctc accgacaccg cccaccccat gctggccgcc accaccgcac tgcccaccac 63660
cgacggcacc gtcctcaccg gccgcatctc cctacgcacc cacccctggc tcgccgacca 63720
caccatccag gacaccgtcc tgctccccgg caccgccttc ctcgaactcg ccgtacgcgc 63780
cggagacgaa accggctgcg acaccatcga cgaactcgtc atcgaaaccc ccctcaccct 63840
ccccgccacc accgccgtcg acctcaccct caccatcgac ccacccgaca ccacaggaca 63900
ccaccccctc accatccacg cacgccccga aggaacccac acctggaccc gccacgccac 63960
cggcaccctc accaacacaa ccaccgaccc ccacgcccca gccaccacgg acgtccccgc 64020
cggcctggac gtcccggacc cggacacctt ccgccactgg ccgccaaccg gcgccaccgc 64080
catggacatc acggagttct atccgcggct ttccgcgctg ggctaccggt tcggtcccac 64140
gttccgaggg ctgcgggcgg cctggcgtga cggtgacacc gtctacgccg aggtggcgct 64200
ccccgaggac cgtgccgccg acgccgaccg ctacggcgta cacccggccc tgctcgacgc 64260
ggccctacag agcggcagcc tgctcatgga gaagggggaa ggcgagcagg gcgtgcaact 64320
gccgttctcc tggcacggcg tccgcttcca cgcgatcggg gcgacctcgc tgcgggtggc 64380
gatcgtgccc ggccctgatg gcctccggct ccgtgcggcg gacagcgaga accaccccgt 64440
cgtgaccatc gacgcgctgg tcacccggcc cccggccgat ctcgcgcccg ctgagcccgt 64500
gctgcgggtc gggtgggccg cggtgcccgt acccgccgag gtccacccgt cggacgcgga 64560
cgtgctgacg ctgcacagcg acgacgccga cccggtccag gagaccaggc agctcaccac 64620
tcgggcgctc gacgcgctgc tcctggccga gcggaccctg atcgtccagg ccaccggtgg 64680
tctcgccacg atggcggccg cgggactggt ccgcacggct cagaacgagc agcccggccg 64740
tttcttcctg gtcgagacgg acgccggagt ggtcctggac agttcgcggc gtgacctgat 64800
cgtggcgctc ggagagcctc ggctgcggct gcgcggcgac cgtttcgagg cagccaggct 64860
gatgcgggcc gcaccggcgc tgacgcctcc ggccactggg tcgtggcagt tgcggcactc 64920
cgccaccggc tcgctggacg atctcgccct cgtccccacc gacgggcccg accgaccgct 64980
cgcagccggc gaggtgcgga tcgcggtacg cgcggcgggg ctgaacttcc gcgatgtcac 65040
cgtcgccctc ggcgtcgtcg ccgatacccg cccactcggc agcgaggccg ccggggtcgt 65100
cctggagacc ggccccggcg tgcacgacct ggcgccgggc gatcgggtcc ttggaatgct 65160
cgccggcgcg ttcgggccgg tcgcgatcgc tgatcggcgg ttgctgggcc ggatgccgga 65220
cgggtggacg tatccgcagg cggcgtcggt ggtgaccgtg ttcgcgaccg cctggtacgg 65280
cctggtggac ctggcgaagc tgcgccccgg cgagaagatc ctcatccacg cggcggcgac 65340
cggggtcggc gcggcggccg tacagatcgc ccgccacctc ggcgccgaca tctacgccac 65400
cgccggcgca cccaagcagc acctcgtgga cctggacgac gccacccacc tcgccgactc 65460
ccgcaccccc gagatgaccg ccaccttccc cccggtcgac gtcgtactca actccctcac 65520
cggcgacctc ctcgacgcct ccgtcgccct cctcgccccc ggcggccggt tcatcgaact 65580
gggcaagacc gacctccgcc acaccgtcca acaacccttc gacctggtcg acgcgggccc 65640
cgaccggctc cagcagatca tcaccgaact cctcggcctc ttcgccgaca acaccctcca 65700
cccgctaccg gtccgtgcct gggacgtacg acgggcgcgg gaggcgttcg gattgatgag 65760
cagcggccgg cacacgggca agtcggtgct gacggttccc cggcccctcg accccgaggg 65820
cgccgtcctc atcaccggcg gctccggcac cctcgccggc atcctcgccc gccacctcga 65880
ccacccccac acctacctcc tctcccgcac cccaccaccg gacaccaccc ccggcacgca 65940
catcccctgc gacgtcagcg accccaccca actcaccacc gccctccacc acatacccca 66000
acccctcacc ggcatcttcc acaccgccgg caccctcgac gacgccctcc tcgaccacct 66060
caccccccac cgcgtcgaca ccgtccttaa acccaaagcc gacgccgcct ggcacctcca 66120
ccacctcacc caacacaccg acctcgccgc attcgtcctc tactccgcgg tcgccggcgt 66180
catgggaagt cctggccagg gcaactatgt ggcggcgaac gcgttcctcg acgcgctcgc 66240
ggaacaccgg cagtccatgg ggctgcccgc tcagtcactg gcgtggggca tgtgggcgga 66300
tgtcagcgcg ctcaccgcga aactcaccgc cgcggaccgt gatcgcatcc ggctcagcgg 66360
gttcccgccg ttgagcgcgg aggacggcat gcggcagttc gacgcggcga ggcgtacgcc 66420
ggagccggtc gtcgtctcga cgaccgtcga tgtcacccgg ctcgacgccg gccaggtcgc 66480
gccgctgctg cgcggtctgg tggcccacag gggcggcccg ttgcgcgcgt cggcccgtaa 66540
cgccggtgat gagccgttgg cggtccgtct cgccgggcac accgtcgccg agcagcggcg 66600
cgtgatgcag gaggtggtgc tccgtcaggc ggctgcggtg ctcgcgtacg ggccgggcga 66660
acaggtcgcg gccgaccggc cgttccgcga gctcggtttc gactcgctga ccgccgtcga 66720
cctgcgtaac cggctcgcgg cggagacggg gctgcggctt ccgacgaccg tggtgttcag 66780
ccacccgaca gcggactcac tcgccacgca tctgctcgaa ctgctcgacg ctcgcgccgc 66840
cgaggccgtg ggggcttccc tgccctcggt ggccgccgag cccgccaccg ccgtgcggga 66900
ccaggacgag ccgatcgcga tcgtggcgat ggcgtgccgc ctgcccggcg gcgtgacctc 66960
gcccgagggg ctgaggcagc tcgtcgagtc cggtaccgac gcgatcaccc tggtgccttt 67020
ggagcgcggc tgggacctcg acgcgctgta cgacccggac cctgacgcgg tgggcagggc 67080
gtacagcctg cggggcggat ttttggaggg tgcggccgag ttcgacgcgg cgttcttcga 67140
catcagtccg cgggaggcgc tcggtatgga tccgcagcag cgtctgctgc ttgagacggc 67200
ctgggaggca atcgagcgcg gccggatcaa ccccgcgtcg ctgcacggca gggaggtcgg 67260
cgtctacgtg ggtgccgccg cgcagggcta tgggctgggc gccgaggaca ccgagggcaa 67320
cgcgatcacc ggtggctcca cgagtctgct gtccggccgg ctcgcctacg ttctcgggct 67380
ggagggcccg tccgtcaccg ttgacacggc gtgctcgtcg tcgctggtcg cgctgcacct 67440
ggcgtgccag gggctgcggc ttggcgagtg cgaactggcg ctggcgggcg gggtctccgt 67500
gctgagctcg cctgccgcgt tcgtcgagtt ctcccgtcag cgcggtctcg cggccgacgg 67560
gcgctgcaag tcgttcggct cgggcgcgga cggcacgacg tgggccgagg gtgtgggtgt 67620
cctcgtcctg gagcggctct ccgacgccga gcggctcggc cacaccgtgc tctccgtcgt 67680
ccgaggcagc gccgtcacgt ccgacggcgc ctccaacggg ctcaccgcgc cgaacggcct 67740
ctcccagcag cgggccatcc gtaaggcgct cgcctcggcc gggctgaccg ccgccgacgt 67800
ggacgtcgtg gaggggcacg gcaccggcac caggctcggc gaccccgtcg aggcggacgc 67860
cctgctcgcg acgtacgggc agaaccgcga ggagccggtc tggctgggtt cgctgaagtc 67920
gaacatcggg catgcgacgg ccgcggccgg ggtcgcgggg gtcatcaaga tggtgcaggc 67980
gatcggggcg ggcacgatgc cgaggacgct gcacgcgcac gagccctcgc ccgccgtcga 68040
ctggagcgcg gggcaggtgt ccctgctcac cgagaaccgg ccctggcctg acggggagcg 68100
tccgcggcgg gcggccgtct ccgcgttcgg gttgagtggg accaacgcgc acgtcatcct 68160
cgaacagcac cgtcccgcgc ccgtcgcgcc ccggccgccg cgcgaggagc cccggccgct 68220
gccgtgggtg ctgtcggcgc ggacgccggc ggcgctgcgg gcgcgggccg ccgggctccg 68280
cgatcacctg gtgacggcgg gggacgcgga cccgttggac atcggatacg cgctggccac 68340
cagtcgcgca ccgttcgcgc accgtgcctc ggtcgtggcc tccgacctcg acgggttccg 68400
cgccgcgctc gacggcgtcg cggagggctc ggaggcgccg ggggtcgtca tcgcaaccgc 68460
cagggagcgg cgtgtggcct tcctcttcga cggtcagggc gcccagcgtg tcggcatggg 68520
acgcgaactc caccggcgtt tccccgtatt cgccgaggcg tgggacgagg tgtcggacgc 68580
attcggcacg tatgtggagc actcccccac ggatgtcttc cacggcgagc acggtgatct 68640
cgcccatgac accttgtacg cccaggccgg cctgttcacg ctcgaagcgg cgctgctgcg 68700
gctcctcgat cactggggtg tgcggcccga cgtggtcgtc gggcactccg tcggtgaggt 68760
gacagcggcc tgggcggcgg gggtgctgac actggcggac gcgacggcgt tgatcgtggc 68820
ccgtggacgg gcgttgcggg cgctgccgcc cggggcgatg acctcggtcg agggaagcgc 68880
ggcggaggtc gccgcgttca cggatctgga catcgccgcg gtcaacggcc cgtccgccgt 68940
ggtgctcacc ggctcaccgg acgatgtggc cgcgttcgaa ggggagtggg cggcggccgg 69000
gcggcgcgcg aggcggctcg atgtcgggca cgcgttccac tcccggcagg tcgacggcgc 69060
cctcgacgag ttccgtacgg tcctcgaatc gctctcgttc ggcgcggcgc ggctccctgt 69120
ggtgtccacg accacgggcc gtgaggcggc gggcgatctc cggacgccgg agcactggct 69180
gcggcacacc cgccgcccgg tgctgttcgc ggacgccgtc gggcaactcg cggagctggg 69240
ggtgaacgcg ttcgtggccg tcggcccttc cggggcgctg gcgtcggccg cgtcggagaa 69300
caccggtggg gaagccggga cgtaccacgc ggtgctgcgc ggccgggtgg gcgaggagac 69360
ctcggtgctg accgccgtcg ccgaactgca tgcccacggc gccccggtcg acctcgccgc 69420
tgtgctggcg ggcggacgcc ccgtggacct tcccgtctac ccgttccagc accgctcgta 69480
ctggctggcc cctgtcacgg gaggcagtgc accgacggcc gcggtgggga ccggaccact 69540
cgctgagccc gagccggacg acctcaccgt cgccgagatc gtccggcggc gcgccgcgac 69600
gctgctcggc gtcacggacc ccgccgacat cgacgcggac gcgacgttct tcgcgctcgg 69660
tttcgactcg ctggcggtcc agcggctgcg caatcagctc accgccgcga ccggcctcga 69720
tctgccgacg gccgtcctgt tcgaccacga caccccggcc gccctcatcg attatctgga 69780
ggaccagctg ggtgaggacg aggacgcgga cgacgacgaa cccaccgtcc tcgcgctcct 69840
ggcggatatg gagtcgctcg accccgctga catcgcggcg acgccggcct cggagcgtgc 69900
ggccatcgcc gacctgctcg acaagctctc ccgtacctgg aaggaccacc gatgagcacc 69960
gacacacccg ccgggacgcc gcaggccggg cgctgcccgt tcgcgatcca ggacgcccat 70020
cgggcgatcc tggacagcgc cacggtcggc tcgttcgacc tgttcggcat caagcactgg 70080
ctggtcgccg ccgcagagga cgtcaagctg gtcaccaacg acccccggtt cagctcggcc 70140
gcgccctcgg agatgctgcc cgaccggcgt ccgggctggt tctccggcat ggacgttccc 70200
gagcacagcc gctatcggca gaagatcgcc ggggacttca cgctgcgcgc cgcgcgcagg 70260
caggaggagt tcgtcttcga ggccgctgac gcctgtctgg acgagatcga ggccgctggt 70320
cccggcgccg acctggttcc cgggtacgcg aagcggctcc cctcgctcgt catcaacgcg 70380
ttgtacgggc tcacccccga ggagggagcg gtacttgaga cgcgtatgcg cggtatcacg 70440
ggctcgaccg acctggacag tgtcaaaacg ctgaccgacg acttcttcgc gcacgcgctg 70500
gagttggtcc gtgccaaacg cgacgagcgg ggcgacgatc tgctgcaccg gctggcctcg 70560
gccgaggacg gcgagatccc gctgagcgac gacgaggcga cgggggtgtt cgcgacgctg 70620
ctgttcgccg ggcacgactc ggtgcagcag atggtcggct actgcctcta cgcactgctc 70680
agccaccccg agcaggaggg ggcgctgcgc acacgcccgg agctgatcga cggcgcggtc 70740
gaggagatgc tgcgtttcct ccccgtcaac cagatggggg tgccgagggt ctgcgtcgcc 70800
gatgtggatc tgcgtggtgt ccggatcagt gtgggagaca acgtgatccc gctctattcg 70860
acggccaacc gcgacccgga ggtgttcccc gacccggaca cgttcgatgt gagccgcccg 70920
acggagggga acttcgcttt cggtcacggc gtccacaagt gtcctggcca acacgttgcc 70980
cggctgctca tcaaggtcgc ctgcctgcgg ctgctggagc gtttccctga cgtccgcctc 71040
gtcggcgacg taccgatgaa cgagggcctc gggcttttca gcccggccga gctgcggatc 71100
acctggggtg cggcgtgagt gacgtggtgg agaccttgcg gctgccgaac ggcgcgacgg 71160
tcgcgcacgt caacgcgggc gaggcgcagt tcctttaccg ggagatcttc acggaccgct 71220
gctatctgcg ccacggcgtc gaactgcgcc cgggggacgt ggtgttcgac gtcggcgcca 71280
acatcggcat gttcatgctc ttcgcccatc tcgaacatcc cggtgtgacc gtgcacgcct 71340
tcgaacccgc gcctgtgccg ttcgccgcac tgcgggcgaa cgcggtacgg caccgcgtcg 71400
ccggccgggt ggaccagtgc gccgtttccg acgaggccgg cgtacgcagg atgacgttct 71460
accccgacgc cacgctgatg tccggtttcc acccggacgc cgccgcccgc aaggagctgc 71520
tgcgcaccct cggcctcaac ggcggctaca ccgctgagga cgtcgacatg atgctcgccc 71580
aactgcccga cacgggagag gagatcgaaa cctcggtcgt ccggctctcc gacgtcatcg 71640
cggagcgtgg catcgcggcg atcggcctcc tgaagatcga cgtggagaag agcgaacggc 71700
gggtcctcgc cggcgtcgag gacgccgact ggccccgcat ccgtcaggtc gtcgcggagg 71760
tccacgacgt cgatggcgcg ctcggtgagg tcgtcgcgct gctgcgcggc catggcttca 71820
ccgtcgtcgc cgagcaggat ccgctgttcg ctggcacgga gatccaccag gtggccgcgc 71880
ggcgtacggc cggctgagcg gctccggcag caggggcgcg gctacccgca ccggcggtcg 71940
cggcccgcgg gctcaccgac atcggccagt tccctcggaa gctgctggcg gcccttcacc 72000
cccagtttgc ggaatacgtt ggtgaggtgc tgttccacgg tgctggccgt gacgaacagt 72060
tggtcggcga tctccctgtt ggtgcgcccg atcgcggcga gcgcggcgac ccgtcgttcc 72120
gactccgtca gtgaggcgat ccgctgcccc ggcggcgcgt tccaggcgcc gccgatgtcc 72180
gagggctccg cgccgagcct gcgcagaagc ggagcggcac cgcactgggt cgcgaggtgc 72240
cgtgcccggc ggaacaggcc ccgtgcccgg ctgtggtgcc tgaccatgct ggacgcctcg 72300
gccaggtcgg tgaggacgtg cgcgagttcg taccggtcgt tgcaggtgac gagcaggtcg 72360
gcggcctctt cgagcaggtc gatccgttgg ggcaaggggc tgtaggccgc ctgtacccgc 72420
agcgtcagca cccgtgcgcg ggcccgcatc ggccgggaca gctgctcgga gatgagccgc 72480
agtccttcgg cgcggtcacg gccgagcagc agcagcgact cggcggcgtc gacccgccag 72540
agcgccaggc caggcacgtc gacggcccag cgccgcatcc gctccccgca ctccctgaac 72600
gccgtgtggg ccgcccggta ccggccggta gcgaggtggt gctgtccgcg ggcccagagc 72660
agatgcagcc cgaagagact ctccggcgtc tcctgcggca gcggccccgc gagccaccgc 72720
tcggcccggt cgaggtcgcc gagccggatc gcggcgacca cggtgctgct cagtggcagc 72780
gcggcagcca ccccccaggt gggcgcgtgc cggggcccga gcgccgtctc gccgtactcg 72840
acggccgagg tcagatcgcc gcggcgcagc gcggtctcgg cgttgaaccc cgcgtggacc 72900
gcctcgtccg ccggtgtccg cgtgccctcg tcgccggcca gtttgtcgac ccagaactgg 72960
acggcctcgg tgttctccgc gtagagcagc gccagcaacg ccatcatggc cgtggtcctg 73020
tccgccgtgg cgtgggtgtg ctggaggacc cgctcggcgt ggacatcggc ccgctcgtag 73080
cggccgcgca gcgcggcgat gacggccttg tcggcgacgg cgcggttcct ggcgggtccg 73140
ggcagcgcgg cgagtccgcc ggaggcgaac gggtcggtcc tgtgtgcggg gtccgacgcg 73200
ccggggtgga ccagtccgag ggataactcg ccgacgcgca ggagcgcctt gttctgctcg 73260
ctgccggccg cgggccgctg cgccgcgagg acctcggccg cctcgtccgg gcgcccgccc 73320
atcgccagcc agtcggcgag cgacacggcg tgctcggggg agagcagccc cgcgcgggac 73380
gcggtgagca gctcgggcag gtgccggccg gcccgcaccg ggttgcagag gcgttcgatc 73440
gcggcggcgc cgacgcgcag tgcggcgcgc gtgccggggt cgtccgaggc ccggtgggcg 73500
agttccaggt atccggccgc ctcgtcgagt tcgccgcgca ggtgatgctc acgcgcggcc 73560
tcggtgaaca gtgcgacgac ctcggcgccg tgcacgcggc cggtgccgat ctggtgacgg 73620
gcgagcacgt tgcccgccac gccgtggtcc cgcagcagtt ccagcgccga ttcgtgcagg 73680
ttgcggcgtt ccgacgccga caggtcgtca aggacgatgg accgggcggc cgggtgcggg 73740
aaccggtcgc cctgcaacag ccgcccctcg ttcaactgtt cgtatacttg ttcgacggtc 73800
tccccgccca gtccggtcat ccgctggacg agcacgggct ccgtactcgc gctgagcacg 73860
gcggaggccc tggcgacacg cagcgccagc gggccgcagc ggtagagcga gcccaggtac 73920
gcgagccggt acgcccgccc cgcgaccacc ccggagcggc ccgccgccca cgcctccctg 73980
atgtcgttga tcaggccgtg cccgaggagc aggtttccgc cggtcgcccg gaacgtgtcg 74040
gcgcagatgt cgtcgtgcgc ctcctcgccg agctgcccgc gtacgagttc ggtggtctgc 74100
gcctcgttga gcggccgcag cgcgatctcc tggtaggaac gcaggctcag cagttccgcc 74160
tggaaacgcg agtcggccgg ggtcggcctg cgcagctcgg tcagcacgac cgcgatacgg 74220
gccgggccga tgcggcgcac gaggtggagc aggcagcgca gcgatgccgg gtccgcgtgg 74280
tgcacgtcgt cgatgccgat cagtacgggc cagtccgcgg cgagcgccag cagcgtgcgg 74340
gtgaactcgg cccgcagccg gttgtcggta ccgtcctggg ggtcctcgca cgaggccgtg 74400
aggcggaccg gctccggagc ctgggcggcc agcacgggat ggtcgaagag ctggccgagc 74460
atcccatagg gcacggcgcg ctcctccatg gagcacaccg cccggagggt gacgaagccc 74520
gcctcggccg cgccggcgtc gagcagtgcc gtcttgccgc tggctatcgg tcctgtgatg 74580
gcgacgacca ggccccgtcc actccccgcc ctggtgagtg ccgagtggag gcggctcagc 74640
tcgtcatcgc gggcgatcag ttcatcgggg gctgctcgca cttccggaac cacctcgcgg 74700
ccgtagtcga aatcggtcgg cgccaagcac agtctcttgg catgtacggc tatgaatggt 74760
cttacatgta cggctttgaa tggccttaac gggtggcatg gtccgcttct tcgggcgcac 74820
cggcctcctg cgccgcgagc ctcgcgcctc gcgccaccaa ctcggccacc cggtccaggt 74880
gatcgacgag gtagaagtga ccgccggtga agatctccac ggtcgtcggc gcggtggtgt 74940
gcccggccca ggcacgggcc tgctccaccg tcgtcttcgg atcgctgtcg ccgacgcaga 75000
ccgtgaccgg cgtgtccatc ggcggcgcgg tctcccaccg gtacgtctcc gccgcgtagt 75060
agtccgcgcg cagtggcggc aggaccagcg cgcgcagttc gtcatccgcc agcacgtcgg 75120
cgctggtccc gccgagagct gacaccgttg ccagcagttc ctcgtccgac gccaggtgga 75180
cggtgtcggt gagggcgtgc gagggcgcgc ggccgcccga gacgatcaga tgggccaccg 75240
ggagccgctg ggccagctcg aacgcgagtg tcgcccccat gctgtggccg aagagcacca 75300
acggccggtc gagacccggc ttcagcacgt cggccacgcg cccggccagg gtgcgcaggt 75360
cccgtaccgg ttcctcgtcc cgacggtcct ggcgtccggg gtactgcacg gcgtacacgt 75420
ccgccaccgg ggcgagcgcg cgagccagcg gaaggtagaa ggtcgccgac cctccggagt 75480
ggggcaggag caccacccgt acgggggcgt cgggcgtcgg gaagaactgt cgcaaccaga 75540
gctcttccct catcgcacac ccccggcggg ggccaggggc accggaaggc gggctccgag 75600
cgtcgcgtgc cccgcggccg gcaccgcgcc gggctcggtc gtcgggacgt cgcgcacgtg 75660
cggcggcttc tcggaacgct tgccccgggt ccgcacccct tcgcacaagt ccgtctcgtc 75720
ggcgagcccc acggctccct gacggctctt gagatcgcac atgccggcct ccacttccga 75780
gatcgcgaat cgaccctaac ggcgctggtg acggccgtga cacccctgac cgaatcagcc 75840
accccccagc accgcggctg gggtcacttg acagcgatca cccggtgtca ctcagataac 75900
acgagaaccg cccggccgta gccggtacgg gtggaagggg tttccccgag gcggtcacga 75960
aagcggcgac gcgggtcgcc cccgaagacg cccgcgtcgc attcgcatgc cgttgaggcc 76020
gctctccccg gggacggcgg cttcggggtc ctcgcggcgc gggcggtgag gcggccgtcc 76080
tggggccgcg tggatcaggc catgaagcgg ggagaccggc ccctcaactc gccgacgcgg 76140
tgctcccgtt cgcgcggcgg gtcgccgttc cctgccgatg aacaccccgg cacgcagcgg 76200
cgcctcctca acgggcagcc cgacgcgaca agcgtgcgag ccgccagacc atggcgccgg 76260
tcgcgatcgt cagcccgatc gcgacgagcg ccgtccatcc catcgccccg gcgtagccgt 76320
cggcgccgtg acgggacccc agcacggtgt agaagaaggt gccgatcacg gccaccccca 76380
tcgccgacgc gaactgctgc gtggtcgaga gcactccgga ggcggaaccc gcctggtgcg 76440
gccgtaccag ggcgagtgtc gcgccgttga gggcgggcag cacgacgccg ttgccggtac 76500
ccacgatcga gagggccacg acgacgaccg gcagcgcgac ctgtcccgat gacacaccga 76560
gcgccgtcgc cagcagagcg agacccgcgg cgatcaacgc cgagccggcc aggaccacct 76620
tcagcccgtg gcgggcgatg agccgtttgc cgaccatgga cgacacaccg aacaacacgc 76680
ccatcggcgc gaagatcagc cccgcctcca ccgggctgtg gccgagaccc gcctggagca 76740
gcagcgtgag agtgaacatg aaactgccga agtagaggta gaacgcggcg ccggcgagca 76800
gtcccgttcg aaacggcgga ctgccgaaga gcgagagttc cagggtcggc gtgccgcccc 76860
tggccgcaag ccgttgctgt cggcgcacgg tcgcgaagcc gacgggcacc gcggcgacca 76920
cacaggccca ggtccagagc ggccagtgcg cgtcacgccc gagcgtcaac gggaccacga 76980
gcagcgccag cgagcccgcc acaccgagcg cgccaagggg gtcggtcgcg ctcccggggg 77040
cggacgtggg ggcgtcggcg gcgcgccccg gcagcacacg cagcgccacg aacgcggcga 77100
ccaccccgat ggggccgttg acgaggaaga tgacgcgcca gccgagcccg aacacgtcgg 77160
cctggagcag catccccccg agcacctgcc ctgcgatgga cccgatgccc gccgccgcgc 77220
tgtaccaggc gatggcggcg ggtcgtgcgg tggcggggaa cacggcggtg accgtggcaa 77280
gcacctgggg caccatcgcg gcgcccgcca acccctggag cagccggaac acgacgagtt 77340
gggccggatc ggccgccaca ccgcacagca ccgaggcgac ggcgaaaccg agcatgcccg 77400
cgacgaacat ccggcggtgg ccgaagaggt caccgagtcg gccgcccgtg atcatgccgc 77460
tcgcgtacgc gaaggcgtac ccaccgacga tcagttccag cgcggcccgg cccgcgtgca 77520
ggttcgccga caaggacggc gcggcgacgt tggcgacaaa gaagtcgaat tgggccatga 77580
agaccgcgac gagcagcaca ccgagcatgc gccctgtcct cgggggcgga gcggacgtgc 77640
cgccttccgg ttcacctgtg gacgttgcgt ctgtcctcga acccgcgcgc ctggacgcgg 77700
cggcactctc ggcggtcatg ggatcccatc tcgacgactg cgtcccggac tcggccgttc 77760
cgcgtcaacg gtttcagcga attgaattta tcatggataa actatgtcca ctatctctca 77820
tctctaggat ggagacatga agctgtctca gggagtcgaa tggggcgtgc actgcgcggt 77880
cacactggcg cagacagcac ctggagtgtc ggtgtcacgg cggacgctgg cggagcgtta 77940
cggcctctcg gaggcgtacc tcgccaagca cctcaaggcg atggccggcg cgggcctgct 78000
gtacgccatg acgggcccca acggcggttt ccggctggcg cgttcccccg agcggatcac 78060
cgtgctcgac gtggtggagg ccgtcgaggg cagcgggccg cacttcgtct gccaggagat 78120
ccggcagcgc ggtacggccg cgctggcgcc ggagcactgc cgtgaacgct gcggcgtcgc 78180
catcgccatg gacgaggcgc gggaggcctg gcgctcctca ctccgcgcgg tcacgatcgg 78240
cgacctcgtc gcacgcctgc ccgctgcggc aagggccggg cacgcgcgtt ccggtgggcc 78300
ggtcacgccg tagcgacgcg ggcgccgtca cggagcccgc cgggccgccc gcgccacccc 78360
ctagactcgc cgcatgacgg ggagctctga ggcgggtggg taggcgtcct ggcggtcggg 78420
tgacgttccg ggccatcgcc gacgaggcgg gcgtctcgat cgccacggtg tcccgggtga 78480
tcaacggtca ggtgccggtc tcccccgcca cacggcagat ggtgcggcag gcggcgcggc 78540
ggctcggggg cggactgacg gaggcacggc ccctcgcgcg gccggtcttc atctactgcc 78600
cttacgcgct gaccgactac ttcggcacca tcgtcacctc cgtcgtcgag accctggcgc 78660
tgcacgggtc tcgggcgctg gtgcacgcgg gcgagagcgc ggtgggcgac accacctcac 78720
tgctcgcact gcccgaggaa cccggcatcg cgggggccgt actggtgctg ccgccgagtt 78780
cgacgcggga cctggcggcg ctgcacgcgc ggcgctaccc gctggtggtc gtggacccgc 78840
gcgtggaact gcccgaggac gtggcctcgg tctcggccgc ccacgccgcc ggggcgcgcc 78900
gggtcactca gcacctgctg ggcctgggcc accggcggat cggcttcatc ggcggccccc 78960
gttcctggct ggccagccgc aaccggctgg tggggcacac cgccgccctc gccgagaccg 79020
gtctgctgcc cgatcccgcg ctgacggcgg agatcaccga gcccaccacg gagcaggggc 79080
acacggcggc gctgcggctg ctggccgggg agcctcggcc caccgccctc gtcgccttca 79140
acgacaagac ggcggccggg gccgtgcgtg ccgcccgcga gaaggggctg acggtcccgg 79200
gcgatctgtc ggtcacgggg ttcgacgaca gtgagctggg gcagagcatc acccccgcgc 79260
tcaccaccgt caggcagccg ctggaggaga tgggccgtat cgccgtgtcg ctgctgctgc 79320
ggctgatcgc ggggcacgcg gtggacaccc tgcacgtcga actggccacg ccgctcgtgg 79380
tcagggagtc gacggcgccc ccgcgatcag ctcagtgacg taacggacgg ccgaccggtc 79440
gcacggtcgg ctttcgcggc cgccctcgca tccgatctct gcttcgtttg aaacaaaaaa 79500
tgaagcatgt tgcgcgaccc cgcccaccga gcggctccat tcctcgcaca cagaccgccg 79560
gccgcccccg tccttttccc cggcccgtcc ctgccgcacc gatcagccgg ccgcttctac 79620
caggacgtac ggcgaaaccc cttcccacat acgccgttgg ggttgacggt ccgatagccg 79680
cgctctaact tcacgtgttg taaaaagccc tgcacccttc gtgtcacgtg acgtcccgcg 79740
tcgacgcgtc cgcgtggggc ggctgccgca ccgcgggcac cgtcggacga tcggcgcccc 79800
attgttttgc acggcatatg taaatgtttc ataccgtgcg tgctcccctg cgcgtgcggt 79860
gcgcgacggg ccgctcgccc cgacaggccc cgcttacccc gctcaggaag gacaccgccg 79920
catgtcccct gcccgcacac gcctcagacg gcgttcccgt ccgccgaccg tcgcgttcgc 79980
cgtcgtcctg ctcggcgccg ccaccctggt cgccgtggac ggcaccgtcg ccgacgcggc 80040
gacacccggt ccgatcgtca accagggcaa cggcaagtgc ctcgacctca aggacggttc 80100
gaccgccgac ggcgcgggcg tccagatgtg gtcctgttcc tcgggcccca accagacctg 80160
gacgcgagac gccaacggct cgctcaccgt caagggcaag tgcctcgacc tcgtgaacaa 80220
cggcaccgcc aacggcacct ccgtgcacct gtggtcctgc tacgactcgg tcgccaccca 80280
gaagtggcag tacaccgccg ggcacgacct ggtgaacctc gccgccggca agtgcctcga 80340
catcaaggac aacaacaact ccgacggcgc cgcactccag gtctgggact gcgcgggcac 80400
ccccaaccag aagtgggagt acgcgggcgc gggcacgcct gacccgccca cgggcgacaa 80460
ccccgacctc ggcccgaaca ccgtggtctt cgacccctcg atgtcctccg catccatcca 80520
gagcaagctc gacgcgatct tcagccagca gcagaccaac cagttcggcg gccggcgcta 80580
cgccgtgctc ttcaagccgg gcacgtacga cgcggacgtc aatgtcggct tctacaccca 80640
ggcggcgggg ctcggcctga gccccgacga cgtcaacatc aggggcgcgg tgcacgccga 80700
ggccgactgg ttccagggca acgccacaca gaacttctgg cgcgacgcgg agaacatgtc 80760
ggtcacgccg aagaacggct acgaccgctg ggcggtgtcg caggccgccc cgtaccggcg 80820
gatgcacgta cgcggggacc tcaagctcga cgacggcggc tggtcgagcg gcggcttcat 80880
ctccgacagc aggatcgacg ggcagatcca gtcaggttcg cagcagcagt tcctgaccaa 80940
gaacagcaag atgggttcct ggtccgggtc gaactggaac atggtcttcg tcggtgacca 81000
gggcgcgccc gcgcagagct tccccacgta caccacggtc ggcgccgcgc ccgtcaacgc 81060
ggagaagccg ttcctgcacg tcgacggggc ggacgcctgg aaggtgttcg tgccgggact 81120
ccagaccgac gccgccgcga ccacctggag cggaaagaca cagaccgggt cggacctgcc 81180
catcgaccgg ttctacatcg ccaggccggg cgccggcgcg gccgacatga acgcggccct 81240
cgccgcgggg aagaacctgc tcatcacccc gggcgtctac cacctcgacc agacactcaa 81300
ggtcacccgc cccgacacgg tggtactggg tatgggcctg gccaccctcg tgccggacaa 81360
cggcatcacc gccgtgtcca ccgccgacgt ggacggcgtc aaggtcgccg gggtcctcat 81420
cgacgcgggc acgaccaact ccgccacgct gatggaggtc ggccccaccg gctcctccgc 81480
cgaccactcc gccgacccca ccgtgctcag cgacgtcttc ctgcgcatcg gcggcgccac 81540
cgtcggcaga gcgagcaagt ccctcgtggt caacagcgac gacacgatca tcgaccacac 81600
ctgggcctgg cgcgccgatc acggcaacgg cggaacggtc ggctggaaca ccaacaccgc 81660
ggacaccggt ctcgtcgtca acgggcggga tgtcacctcg tacggcctct tcgtggagca 81720
ctaccagaag acgcaggtca tctggaacgg cgagggcggg cgcacctact tcttccagaa 81780
cgaactgccc tacgacccgc ccaaccagag cgcctggacg aacggttcga cccagggcta 81840
ccccgcctac aaggtcgcct ccggcgtcag ccgccacgag gcctggggcc tgggcagcta 81900
cgcgtacttc aacgtgaacc cctcggtcgt cgaggaccat tccttcgaag tgccacagac 81960
gagcggtgtc cgcttccacg acatggtgac caccgtcctc ggcggctcgg gcaccatcaa 82020
ccacatcatc aacaacacgg gcaacagggt gacccccagc aacaacgtcg cctatctgac 82080
cgactacccg tagaggccgt ctccttcacc ccgtacgtgc ggggggcccg ctgccccggg 82140
aagccccccg cacgtcgcac cacccccact ccccccactc cacacctgtc aggaagggcc 82200
tgcgcatgtc ccgtagaccg ggcggccgga tcaccggcgc cccttcccgt gccccgcgcc 82260
gtctgctgcg tctgctgctg accggcgcgc tcaccgccgc aggactcggc gccgccggga 82320
ccgcaccggc gcacgccgcc ggtgagcagg tcaccgccta cctcaccacc accgacgact 82380
ccggtggcag acacgtcacg cgcggactgg agcggcaggc gcccttcgcc ttccagccgg 82440
gcaccgccac cggcgggacg acggtctccg tggacgagaa cacccgctac cagaccttca 82500
cgggcggcgg cgcctccttc accgacaccg ccgcctacct gatgaaggag agcggcgcgc 82560
tctcgcagac ggcgctcgac cagacgatga ccaagctctt ctcccccacc gacggcatcg 82620
gtctctcctt cctgcgcaat ccgatgggcg gctccgacct ggcccgcttc ggctacacct 82680
acgacgacgt ccccgccggt cagagcgatc cctcgctctc caggttctcg ctcgcccacg 82740
accaggccgc cgttctgccc ctcactcagc aggccaagcg gctcaatccg cagctcacca 82800
cggtcgcctc gccgtggacg gcgcccgcct ggatgaagga caacggccag ctcaacggcg 82860
gctggctgaa ggcggagaac tacggcacct acgcggacta tttcgtgaag tacctccagg 82920
gctaccaggc cgccggggtg ccgatcgact acgtgacggc gcagaacgag ccgacctgct 82980
gctccagtta cccctccatg agctggaacg gctcggggct cgcctacttc accaagagcg 83040
aactgcttcc caagctccag agtgcgggac tgaagaccaa ggtgctcgcg cacgactgga 83100
actgggacac ctacgacgcc tacgcggcgc ccaccgtgga cgacgcggcg gtgcgcgacc 83160
acccgaactt cggtgggatc gcctggcacg gctacggcgg cgacatcggc aagcagacag 83220
agatccacaa caagtacccg cgtctcgacg cctttcagac cgagcactcc ggaggcacct 83280
ggatcgccaa ccagcagcgc gaggacatga gcgacatcat cggctacacc cgcaactggg 83340
cgaagtcggt gacgaagtgg tcgctcgccg tggaccagaa ccgaggaccg cacaacggcg 83400
gttgcggcac ctgcgacggg ctgatcaccg tgcacgacgg ggacggccgc agcgggcagg 83460
tcgactacac catcgagtac tacacgatgg gccacctcac caagttcgtc cgcccggggg 83520
ccgcccgcgt cgcctcgacc gcgagcggtg acgtaccgaa cgtggcctgg cgcaacaccg 83580
acggctcgaa ggcgctcatc gcctacaacg actccgcggg ggcgcgcacc ctcaccgcga 83640
actggggcgg ccggcacttc acgtaccagc tccccggcag gacctcggcc accttcacct 83700
ggtcagggga ccagagcggc ggcgaggagc gggcggggac cctgaccggt cccggcggca 83760
agtgcctcga cgcctcgggc accgccaacg gctcggcggc gcggctctgg tcctgcacgg 83820
gcgcggccgg tcaacgctgg acgctcggcg ccgacggcac ggtccgcacg ggcggcaggt 83880
gcctcgacgt caccggcgct tcgaccgccg acggggcgaa agtgcagctc tacgactgca 83940
acggcacggg tgcgcagggg tggacgtacg acgcggcgag ccacgacgtc gtcaacaccg 84000
cggcggacaa gtgcctcgac atcaccgacc gttccacggc gaacggcgcc cgcgcgcaga 84060
tctggagctg cacgggcgcc accaaccaga aatggacgct gaacagctga ccaggtctct 84120
tgcgggagcc tccccgggtc cggccctggg caggacccgg gtcggccggg gagcgggacc 84180
ccgccggttc accggtggag ccccgcggtc aaccgcctca cgcggcgccc tgacctgtct 84240
cgccggccct ccaccaggcc tcgcccgggc cgctcggatg ccacggtccg ggatatcgcg 84300
ggtactcggc ccccgggtgg cccggctcga tgggcagtga gtcgacgtcc gcgccggtga 84360
agccgttgaa cttgggttcg gtggtgaccc tgatcgccga ctgacaggtc atgttcaccg 84420
gctcccagaa cacctcgctg ccccgctgca ccagccggtg gagctggatg cgcatggagt 84480
aggagtaggt gcccggccgg cccgagtcga ctgtggcgga ccagtaccag ccgtcggtga 84540
ccagatcggg ggagccgtac tccgcgggga acatgatgtg ctcgtcgacg gcctcaccgt 84600
agatgtcggt gatcatcgga gcgggatagc tgtggggacc cgaggtgaag tcggtgacga 84660
cctccccggt gacgtcgagg acctcccggt ccgcgaggcg tcccccggca cgccaggtgg 84720
gcctcaccca cgttccgacc accttgcgga tctggtccag atcggccgcg ggagagaggg 84780
ggtccgcctt ggccgtcagg acgtccagtt cctcaagtgc cctgcggtcg ctctgcctgg 84840
cccgaacact ctcgtacccg cgcggcacgg tcggcggaac ggagcccaga ctgaagggga 84900
gccagttgag cacctgctcc gtggcctggg acccgtcatg ccagtgggcg ccgtggaccg 84960
cggtgaccag gctgccggtg ccctgcctct ccgatccgta cagcttcatg ttgtcgaaca 85020
gatagacgtt gtcccgcagg gtgttggccg ccagcgcgtt gccggtgtcc acgagcacga 85080
tgatcgccag ctgttgagtc atggttccac ctcgtcgttg tgtgtggtcc tctgtcggtc 85140
ctgaccgtcc gcgcgtacgc tcacacgcgc atcagcgcgg gcgagtcgac gtgcgggatg 85200
ctggcctgtg ctctccgccc ggctgttgtc gatcaggcag aggctgccgt tgaagagggt 85260
gcttcctgag agggcgccga tgacgtcgac cacggcgatg atgttgactt gcgatgtgca 85320
ggccacgcgt tccttctgct tctacccctg tgcccgttat cccccctcgt aagttctcgg 85380
tcctccgcga acgggccccg gcgcggacgc cggggccctt ccgcgtgacg ggatcagccg 85440
cccggctacg cctgtcctgg gtccatcgcg gccgcgaagt ccggggtgcc gagtggcgac 85500
ttgccacgga tggcgtccac ccactcggcg gttgtggccg tgtaggcgaa gaacgcctgc 85560
acgaccacca gcaccgcgtg gtggatctcc gcggcggaca agctgcccgc ccggttggac 85620
agcgccaggg caccggtcgc gtcggagagc agttcgaccc ggtagccgag ctgggacgcg 85680
tggcgggcgg tcgactcgtc acaggtctgc gtcatgtagc cggcgatggt cagcgtgtcg 85740
acgcccgcac gccgcagcca ctcgtcgagg tcggtgccga tgaaggccga ggggaagctc 85800
ttctccacga gatggtcgtg gcggcgggag gccaccacgt cgtgcagggc ggagccgtgc 85860
gtaccccggg cgaagagggg tgcgccggcc ggagcgacgt gctggacgac cacgacgggg 85920
acgctctcct gggtggcggt gtcgacggcc gcggcgatgt tcgccaggct gatggccggg 85980
gccgggtagg cgatcggcag gccacccgtg acgtactcgt tctggacgtc tatgaccaca 86040
agggcgcgtt tcatgacagg ggtttccctt cggcggggat gcgagtgaac ggtgcgcggt 86100
gtccagagcg acggccgtgc ggggcggggg cgggcattat cggcccgtgc ccgcggcccg 86160
gacgaaggct tcgaacagtg cctgttgtgc ggggtcgtgg cgtgcggtgt gttcggggtg 86220
ccactgcacc ccggcgaacc agccacggcg gctggggagt tccagtgcct cgcgggtgcc 86280
gtcggaggcc cgcgcggtga cactgagccc cgctcccacc cggtccacgt actgtcggtg 86340
gaagcaggag gccgtcacga cctgggtgcc cacggtcagc tcaagcagtg tggcgggctg 86400
gacggacacc tggtggacga ggttgcgatg ctcgcgccgc cagcccgcct gatgctcccg 86460
cagcgtgccg ccgagggcca cgttgacggt ctgcaggccc cggcagatcg ccagcagtgg 86520
cagctcggtg cgcagcacat ggtgggcgac cgccagatcg aagccgtcct gctccgcgtc 86580
ggcgtcgtgt ctgccgccgt gcgagggtgc cttcccgtag cgcgccgggg gcagttcgtc 86640
gccgcccggc agcacgacgc cgtcgaagcg ggtcaggcgg tcggcgacga gtgccgggtc 86700
cgcgctgccg tacggggcgt ggggatggag ggccaccggt tcaccacccg cccgccagac 86760
ggcttcgacc agggcacggg cgacgatctc cgccgagtga cgcagagcgg aggtcgagac 86820
ggcgaaacgt gcggggatgg ctatgagggg gcgtgggggt ggggtcacga gcattcctct 86880
ggcgggaaat tcgggtacgg cgttcaggtc acggcggatc ttcctcggag gctcgcgggg 86940
tctgcgagga gtgggggatc ccggagggct ccgaggtctc ggagggacgt ggggatgtgg 87000
aggacggtgg agacgcggag ggctgtgggg ggacggaaga cggtgcgggc gcggtcgccc 87060
gctctcccgg tcgggccaga aaggcggcgg cgcccagcag ccagacgacg gggatcgtca 87120
gcgccagcca ggtggcggtg gtcctgtcgc cgccgatgag ggtggtcagg ttggccagta 87180
cgagccagat ggctccggcg atgcccaacg cgccgaggga gggcgcgacg gtggtgttcc 87240
agcgcctccg gtccggacgg tggcggcgga agtagacgac gacggagacc gaggtcagga 87300
agtacagcag catgatcgcc agcacggcga cgccgctgaa ccaggagaac agcgtcacga 87360
ccgggtcccg gccggccagc gcgaagggta cgacgagcag gaccgcgatg gctgtctgcg 87420
cgactccggc cgtccagggc gcgccgcgcc ggttcaaggt gcacaggacg tgcgggaggc 87480
ggcgctcgcg ccccagtgag aacaggtagc ggttggccga gttgtggaag gccaggatgc 87540
ccgcgaagag ggaggtggcg agcaggacgg gcagcaggtc accggtccag tcgccgaggc 87600
ggtcggcgat cggctggaag acgaaggccg aggagtcccc gtcctccagg gccttgcccg 87660
cgtccgcggc cgcgtgcgag gcgccgtggg cggagatgat catccacgag gtgagggcga 87720
agaacgcggt gatcagcgtg atggacagat aggtggcgcg gggcacggtc cgttcggggg 87780
agcgggcttc ctcgccgtag acggcggtgg cctcgaagcc gaacatggag gcgacggcga 87840
acatcacggc caccccggga gcgccgtcga gcacggtgtg cggtgagaaa ctcgcggcga 87900
cgtcgagccc ctcaggacct ccgccgcgta ccagcacgac cgcggcgaac accagcagga 87960
tgctggtctc ggcgaccacg aagaccgcca gcacccgggt gcccgtgtcg atgcccgccg 88020
tcccgaggag ttccaccagc gccatggtga gcagggccca cacccaccac ggcaggtcga 88080
ggtccgtgtg cacccgcagc aggtgggcga cggtcgctcc gtagaggccg tacatcgcgg 88140
cctggatggt gcagtacgcg aagagcgcga cggcggcgct gcccgttccc gtggtcctgc 88200
cgagcccctt gccgatgtag gtgtagaacg cgccggggtc gacgacgtgc ctgctcatcg 88260
cggtgaagcc cacggagaac agcaggacga ccgcgccggc ggcgacgtag gcggcgggga 88320
cgccgggtcc gttgccgagg gcgacggaga ggggcacggc tccggcgatg ccggtcagcg 88380
gggcctgtgc ggacaggacg aggaagagga tgccgaggac tcccagggcg ttcggcttga 88440
gccgatgggg ggtggcggcg ggctggtggg gtgcgttggc tggcatcccg gctcctcggt 88500
ggtcggcgga cgggtggcgc ggtgctgtcc tcccgagtac gacgcctcag tgcgaggaag 88560
gggcgggtgt ggcgcccgga ttcactggca attcgtttgg tatcaaacaa cataggcgcg 88620
cccttcgaac cggtcaatcc ccgtggacac ggaccgagtt gggtcggcgc ccttgcggga 88680
aagcggcagg cgtccctacg gttgacatac cgtttgatcc caaacaagcg atgggcggta 88740
gcagcgcgga agctacgccg cggcccggtg cccatctgcc cgaggaggca gcggtgagcg 88800
cacacgaccc cgcccggatt cgccagcact cagaacggct cgcggaggcg ggcatcgatg 88860
tggtccgggt ggtctacccc gacctgctcg gcacggaccg ggcgcgagac gtgctgctcg 88920
gccatctgcc cacggcctgc gaacacgggc tcgccttctg ccgggccgtc taccacacca 88980
ccccgcgcgg cgatgtggtg ccggtggccg gaggactgga ggcggggctg cccgacatag 89040
tcgtcagacc cgacctgagc accttgactc cgctgccctg ggagccgggg gtcgcctcct 89100
gcctgggtga cgtcaccgat cccaggaccg gggcccccac ccccgagtcc ccccgtgacc 89160
tgctgcggac cgtgctcgcc cggtgcgcgg agtacgggct caatccggtc gccggtccag 89220
agctggagta ttttctctgc gaaaccgatt cggcggcgcc agggggcctg cgccgctaca 89280
gcagcgccac cggagtcgtg tacacggcgg ggctgcgcgc cgacccggac aaccacctgc 89340
tgcgcaccct gcgttcgctg cgcgacctgg gcatcggcat caccaacggc aaccacgagt 89400
tcgacggttc gcagttcgag atcaacctcg atcactccga ggcgctggac gccgccgacc 89460
gggccttccg tctcaagtcc tccgtcaagg aactggcccg tgcggaaggc cggatcgcca 89520
ccttcatggc caaacccttc aacgacacgg gcggatccgg cttccatctc cacctgtcgt 89580
gcaccgacgg cgacggcgcc aacctcttcg acgatcccgc gggcgcgcac ggcctctcca 89640
ccaccgccac gcacgccgtg gcggggctgc tcgcccacgc ccccgccctc gccgcgctgc 89700
tgaaccccac ggtcaactcg tacaagcggt tcgggccaga cacactggcc ccgtggctga 89760
tcgactgggg gctcgacaac cgcagcgcca tggtccgcgt accgccggag cgcggcggcg 89820
gcgcacggct cgaactccgc ctcggggacg cctccgccaa cccgtacctg ctggtcgccg 89880
ccgcctgcgc cgccgcgctg ctcggcgtca tggacgcggc gaaaccgccc gccccgctcc 89940
aggggtacgg ctacgacacc gcgggggcgc cgatgctccc caccagtctg tccgccgcac 90000
tcgacgcgct ggaggcggac accggcctca tccgtctcct cggcgaggag ttcgtcgccg 90060
cgtacctcac ctacaagcgc gacgaggtca gccgcttcga cagccacgtc accgactggg 90120
agctcgccga gtacgcggac cacctgtgat ccgccgttca gagactccct cggaggccgt 90180
cctgtgactt caaccccaag gagaacttga tgacggcacc tgtcccggtc gagcccctcc 90240
ctctcgccga cgtcgacctc accgacctcg acggcttcac cgacgcctgg aagccctggc 90300
gcatgttcca caccctgcgc catcaggacc cggtccactg gcagcccgag gccgcgccca 90360
actccggatt ctgggcggtg accaggcaca gggacatcgt cgccgtcgac cgcgacccgg 90420
acaccttcac ctcgacccgg ttcgtcaacc tcgaagagct cgacgacgac cagatcgcca 90480
agcgcgcctc gatcctggag ctcgacggca tccgccaccg cgcgctgcgc ggagtactgc 90540
aacggcagtt cgggaacagc gtcatcagcc ggtacaccga cttcctgcgc gggctgaccg 90600
ccaggaccct ggacgcggcg ttgccgctcg gcacgttcga cttcgtcacc catatcgcgg 90660
ccgacttccc gatcaacgtc ctcgcccgcc tcctcgacgt gccccccgag gacaaccgcc 90720
gcctcatcgc ctggggcaac cgcctcatcg gcaacacgga cccggactac gcggacgtgc 90780
tgctcagcag cccggagagc gagcgctacc gtgacctgcc cttccgctcc cccgcggcca 90840
ccgaggtctt cgcctacggg cgtgagctgg cgcggcagcg acggggaggc gccggcgacg 90900
acctggtctc gcgtctcgtc aacggaacgc cccgcgacgg tgtgccactg tccgaccagg 90960
acttcgacaa ctacttcctg ctcctggtgg tcgcgggcaa cgagacgacg cgccacacca 91020
tcagccactc gatgctggcc ctcgccgagc accccgagca actggacagg ctccgcaagg 91080
accccgctct gataccggtc gccgtggagg agttcctgcg ctgggcctcc cccgtctacc 91140
acttccggcg taccgccacc cgggacaccg aactgggcgg cgcgcacatc ggccagggcg 91200
acaaggtcgt gatgtggtac gcctcgggca accgtgacga ggacgtcttc cccgacccct 91260
acgccttcga tgtgacgcgt acccccaacg accacgtcac cttcggcaag acgagcccgc 91320
atctgtgtct gggcaacatg ctggcccgta ccgagatccg tgtcatgttc gaggagctga 91380
tcccgcgcct cgccgacatc cgcctcgcgg gacccgtccc ccgggtccgc tccaacttcg 91440
tcaacggcat caaggaactg cccgtgacgg tcaccctcac atgaccaccg cgccggcgac 91500
gggccaggtt cccggcgcga cctcaccgcc accacccgcc cacctgaagg agcacacggg 91560
tgaccgggcc ccacgcggcg gcccccgtat gattcggtgc cgtacgaacg tatgaccgtg 91620
ggtgcggcgg agtccgcggc ccagtgacga tgcgagggag cgccccgtgc ccagccagcg 91680
gtccatcagt gcggcggaga gactcgcgga ggcgaagctc ggcggcgtac ccgtccggcg 91740
agagcagatg gcggcggtgg ccaacatcta ccgggccgcc tccgccgtcc ggcagcatct 91800
ggagaattcg gtactgcgcg gctcggatct gacctggacc ggtttcgtcg tgctgtgggt 91860
cgtgtgggtc tggggcgagt cggagacccg acgcgtcgcc gaggaggccg gtatctcgaa 91920
gggcacgctg accggcgtgg cccgcaccct ggagtcccgc ggtctgctgc gccgcacggg 91980
ccatcccagc gacgggcggc tcgtactgct cgggctcacc gaggacggtg agagcttcat 92040
gcgggaggtg ttccccgcct tcaacgagga ggaggccttc gtcacctcgc ggctgagcga 92100
cgccgagtgc cgcagtctcg ccgacgggtt gcggcgtgtg gtgctccagg tcgaggagag 92160
cggcgaggac cggcgcaggg agctgctgaa cggcgaggcg gccacgcccc gccgcagcgg 92220
tcgccgcccc aggggctgac ccgcgcgggc cgcgccgtcg ccgctcaggc ggtcactcgc 92280
gccgccgcca cgagggcgtc gaagaggcgt tgctgcgcgg ggtcctcgtg cgcggtgtcc 92340
tcgggatgcc actgcacggc cacgaacagg ccctcggggc gggtgagttc gagcgcttcg 92400
accgtaccgt cggcggcgcg ggcggcgacc tggagcccct cccccggacg gtccacccgc 92460
tgatggtggt agcaggacgc ctcggcccgc tccgcacccg tgatgcgcgc caccgcggag 92520
cccggggtga ggacgacggg gtgccgtatg tggcggtgcg cgccctgggt acggctcatg 92580
tcctggtgca gcgttccgcc cagagccgtg ttgaccacct ggaggccgcg gcagaccgcc 92640
aggagcggca ccccgtgtgc gagggcccgc ctggcgagtt ccaggtcgaa cccgtcctgt 92700
tcgtcgtcca cgtcgtagac ggtcctgtgc gtctcgctcg ctccgtagcg gcagggggcg 92760
acatctccgc cgcccggaag caggagcccg ccgaaacggg cgagccgccc ggacatctcg 92820
gcggggtcga cgacgccgcc cggcgcgtgc ggatgcagcc cggccggctc gccgcccgcc 92880
cgccagaccg cctcgatcag cgcacgggcg ttgacctccg ccgcgctgtt cagtgccgag 92940
gaggtcgcgg agaaacgggc ggggaccgct atcagcgggc ggtgactcac gggccggtcc 93000
agacggtcct cagctcggtg tacgtgctcc agcgcgtagg ggcctccctc cggtcagcgc 93060
ttcggtggcc tgacgccgcg gaactcccag tcgccgccga gggcggtgga cagcacctcc 93120
tcggactcgg tgggctgggc gcccagctcc gtccggatcg cggtcggccc ggtgacgatg 93180
tggttggtga ggcggccgat gccctcggcc tcgacctcga ccacgtcacc cggtcgcacg 93240
ggccgggagt tggccggggt gcccgacagc agcacgtccc cggggtacag ggtgatggtg 93300
cgggcgatgt cggcgacgag atagtgcatg tcccacctca tctcgtcggt ggaaccgtcc 93360
tggacgatct ccccgttgac gtaggtacgc agccacttgc cgtggaagtc ccagtcggtg 93420
accagccccg ggccgagcgg gcagagggtg tcggagccct tgaccctgag catggagccg 93480
gcgtcggtgt cgcggaagtc gtgcaggccg tagtcgttgg ccacggtgta gccggcgatg 93540
tactgtcccg cttcggcctg ggagatgttg cgcgccgccc tgccgatgac gatggcgacc 93600
tcgccctcgt agttgagcca cttgcagccc tccggccgga cgaccgcgcc cttgtgggag 93660
ttgagcgccg aggtcggctt gtggaagtag gtgggggcgg cgggcagtcc gatcccgaac 93720
tcgtcgaccc tgctgtggtg gttgaggtgg accgcgatga ccttggaggg gacgacgggc 93780
ggcaggtgcg tcgcgtcccg tgccttgacg cggcgcccgt cgcccgcgac gagttcctcc 93840
ccctccctga cggtctccac gatcgtgccg tcgaggagga tgcggcggta ttcgggcatg 93900
gcggtcacct ctctgcacgt ggctggggcc ggcgagtcct ggacgtcgtg cgggaggccg 93960
tcggtgcggg cgctcccgcg cccgtccagc cgtcggcggg gcggtcgaac cagaggtgcg 94020
cctgcccggt gccgatggag ttctcgtact ggccgtactg acgggccttc gcggtgcacg 94080
cctgctcgcc gagggccccc gccatcatca ggtagtggga gaacctcgcc tccggcttgt 94140
acttccagaa ctcgtccatg cggtcgagga ccttgtcgtg gcggccctgc ttgaaccagg 94200
cgatgcgctc gtagtcggcc gcccgcgcct cgggggtgaa gatgtgggcc gggtcgcccg 94260
cctcgtggtc gcgcagttcg cgcagcggcc agaaggtgtg cgacagggcg ccggaggcga 94320
tcaggagcac ccggcggccc ggcgtggcgg cgatgccgtc ggccagggcg cggcccaggc 94380
gcaggtggtc ctccatgtcg ccggtctggc agacgccgat ggtgacccag cgtttgtcgg 94440
gcagcccctc gccgaggaac ttccagaggt tggtcgtggc gtagtagatc ggcaggtacg 94500
tgtcgtcgat cgcggtgatc caggtgccgt gccggtcggc gaacgaggcg atgttgtggg 94560
cgagttcggg gtcgccaggg aagtcgaagg gcatgcggca catgccgcgg ggcagctcct 94620
ccgaggtgaa aaggcccgcg cgccgccgat gcgcggtgat gacgaattcg acggtggtcg 94680
cccagtggga gtcgaggacg acgacagtgt cgtagccgtc ggaggcgaag acgtcctcgc 94740
gcagcgcgcg caggccggtg acgagggtga tctccttgcc ctcgttgagt tccagccggt 94800
cggcctcggg cagcacgatg gtggggacat gggcgagcag gcccgccccg aggatctcac 94860
ccatggtccg tccatccgtt cggtgcggtg acggtggtct tcaggtcgca gtagaagtcg 94920
aagctccagt cgccgccctc acggccgaca cccgattggc gggagccgcc gaagggcgcc 94980
ctgaggtcgc ggacgaagaa gcagttggtc cagacggtgc ccgccaccag ccgcgcggcg 95040
acgcgccgcg cgcgctcgtg gtcgccggtg gcgacggtcg cggcgagacc gaaccgggtg 95100
ccgttggcga ggcgcacggc ctcgtcctca ccggtgaagg tctggagggt caggacgggg 95160
ccgaagacct cttcctggac gatctcggag tcctggtcga cgtcggtgag gagggtcggc 95220
gggtagtaca ggccgtggcc ccggtggcca ccgatgacgg cgcgggcgcc cgcatccagg 95280
gcccgcgtga cgaaaccgtc gaccttctcc agctggtggg ggtggatgag ggggccgatg 95340
tcggtggcct cgtcccgcgg gtcgccctgc acgagcccgg ccgccttctc ggtgaagcgg 95400
cgggtgaact cctcggctgc cgtctcctcg acgaggacgc gggtggccgc gaggcagacc 95460
tggcccgcgt tgtcgtactg ctccaccgcg agttccgcgg ccagctccag gtcggcgtcg 95520
gcgaagacga gcagcggtga cttgccgccg agttcgaggc tgagcggggt gagccgggag 95580
gcggccgacg cggcgatgag cctggccgtc ggcacggatc cggtgaagct gacgcgccgt 95640
acgtccgggt gcgaggtgag ggtggagccg atctcggagc cgtacccctg gacgacgttg 95700
aggacaccgg cgggcagccc tgccgctgtg gcgatgtcgg cgagcagcga ggcggtcagc 95760
ggggaccact ccgagggctt caggacgacc gtgtcgccgg ctgcgagggc cggggcgacc 95820
ttccaggtgg cgagcatcag cggggcgttc cacggggtga tcagcacgca cgggcccgcg 95880
gggtcccagc tgacgtgctg ggcgtggccg cgcgtctcga actccgcgtg cccgagcttc 95940
agcagccggt cggcgaagaa gcggaagttg tgtgccaccc ggggcatcac accacggcgg 96000
tgggagcgca ggagagcgcc gttgtcggcg gtctcgacga gggcgagttc ctcgatgcgt 96060
ttctccacgc cgtcggcgac ggcacgcagc agtcgggcgc gttctgcggg cggggtggcg 96120
gcccagccgg ggaaggccgc ctcggcggcg gcgacggcgg ctgcggcctc cttcgcggtg 96180
gcgcgggcga tcgcgcccag ggcgcggccg tcgatgggcg agacatcggt gaaggtctcg 96240
gtggaggcgg cccggtcgcc gccgatgaag tgccgggtgt cgacggtgac tccggcgacg 96300
gtggtgaggt gctggctcat gtcctgaggc tcctcgtggt cgtaggggtc cttaggggtc 96360
cttgcaatat gggagtccga tcaggccgcg ggggctggtg ccgtgcatcg caaggcgccg 96420
gagagtcctc gtagcggagc tactagggct tttcggcaac gccgcgaggt gcggtgccag 96480
cccccgcggc tcgggcgccc gtatcgcaag caccccctgg gggctcaagc ggcgccggag 96540
gtgcccgact ccagcagtcg gcccccgtcc cacacgacgc cgacctgccg gtagtacgcg 96600
gcgatcggtt cgtggatctc cagccgggcc agttcctcgg tgggcgcctc gaacagttcc 96660
agctcggcct cgcccgtcca gggctgtccg ccttcgaagg aggctgcccc cgactcgacg 96720
agttcgtcca gcgccagccc ctttccgttc tcgatggagg gcagccagcg gtggtgggcc 96780
atggggtggc tgttgacgaa tccgcccgtc gtggagggtt cgcgcagggt gacgacggtc 96840
tgggccaggc gccggtcggc cgccgcgagg gtggcgccga accgggcgcc ggactcgatg 96900
cgcggggccg gcccgtaggg atgtggtcgg gtctggtgga tggagccgag tttcttcggg 96960
tagccctggt gcagtccgcg ggcgatggcg aagtccttgt cgacccagat gtagacgcag 97020
cgtgtgtacg tccgcccccg gtaggcgcat ctgacgacgg cgaacgcctc cgcgtactgg 97080
gcccgtacgg ggtcgagcag ttcctcgccg gaggtggcgc aggactgcca gtcggcccag 97140
atcagcgcga cggccccggg gtcctcctcg gcgagttcca gcggctcggg cagcagttcg 97200
cgtacgcggg cggggtcggt gcggtactcg acggtgatca ggtcaccgga gtagcgccac 97260
ggcgggggcg ggatgagcga cgcggcgccc gtcgccgtct tggggtggaa gtagccacgg 97320
agactggtca cttgtgttcc tcaagtggta cggcgagggc tggttgttcg aggagttccg 97380
cgcggtagcg tgcggcggcg gccacggctc tcctgccgcc cagggcgacg acgccgacga 97440
ggtgttcgcc ccggtggtag ccgaccagga ggtcgccctc ggggtcaccg gctgggtcgc 97500
cgtcgaggac acgcacgtcg tccatgccaa ggacgggggc gccgaaggac tggaggcgga 97560
agtcgtgctg gtcgctccag aaggtcggaa ggggcgcgaa cgggccgagc gggacgccgg 97620
ttcccgtgag gtgggcggtg aggaccctgg ccgcgtgttt ggcggtgtcc gtgggtatgg 97680
accagtgttc gacgcggcgg gccacgccgt cgtagcgggc gttggggaag cgcgcgacgt 97740
caccgacggc gaccacgtcg gggcggcccc cggcccgcag gtgctcgtcg gtcagtaccc 97800
cgttggtgag gtcgaggccg ttgccttcga gccattcggt gttggcgagg gagcccaccg 97860
actcgaccac gacgtccgcg gcgagggcgg tgccgtcggc aaggaccacc ccggagaccc 97920
ggtcgtcacc ctggaacgcg gtcacttggg tgccgagggc gaactggaca ccccgccgtc 97980
ggtgacggtc gagcagcgcc tcggcgagca gagcgccaag ggggccgacc atgggcagcg 98040
gctgcgggtc gacgaccgtg acccggtcgg ccccgagggc cagggcggtc gaggccacct 98100
cgcagccgat gaacccggcg ccgaccacga ccacacgcgc gccggggcgg gtcagcgcct 98160
cccgcagccg cctggcgtcg gccagcgtgc ggacggtgtg ccgcccttgg acaggaccgg 98220
ggcacggcag ccgcctgggg cgcataccgg tggccacgac cagtcccgcg tacggcagtt 98280
gttcgccgct gtcgagctgg acggtccgcc ggtcgaggtc ggccccgacg accctggtgc 98340
ccagccgcca ccgtacgtcc gagacgctgg cgcggggacg gaaggccagc gaggcgaagg 98400
acgccttgcc tgccagcact tccttggaga gcggcggccg gttgtagggc atgtggggtt 98460
cgtccccgac gaggaccacg ggcccgtgcc agcccgcggc gcgcagctgc tcggcggcgc 98520
gcagcccggc catggaggca ccagcgacga cgacggtccc gctcacccct cagtcctcga 98580
tcctgatggc ctggagcgga cagacgtcga cggcctcctc gacctcctcg cgcgacgcct 98640
cggcggcttc gggcaggtgg gccaggcgtc cttcactgtc gaagtggaat acgtcgggag 98700
cggcgaacac gcactggccg tggtcctggc atttgttcat gtcgacgacg accttcatgg 98760
ccggtcctcc agatgacggg gagcgtcgga gagttggagc tacagcggaa ggagctcgaa 98820
ccgctgaggg cgt 98833
<210> 94
<211> 429
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 94
Met Thr Ser Gly Val Ala Phe Leu Phe Pro Gly Gln Gly Ser Tyr Val
1 5 10 15
Pro Gly Val Phe Ala Gly Ile Gly Ala Asp Ala Asp Arg Ile Ser Ala
20 25 30
Arg Val Glu Glu Ile Asp Ala Val Leu Ala Glu Phe His Leu Ala Pro
35 40 45
Val Arg Pro Leu Leu Phe Ser Pro Asp Ala Pro Thr Leu Ala Gln Leu
50 55 60
Leu Ala Ser Asp His Glu Arg Leu Asp Val Ala Ile Leu Ala Thr Ser
65 70 75 80
Ile Ala Leu Ala Glu Leu Leu Asp Ser Arg Tyr Glu Val Thr Pro Asp
85 90 95
His Val Val Gly His Ser Leu Gly Glu Phe Ala Ala Leu Ala Val Ala
100 105 110
Gly Val Phe Thr Pro Gly Glu Ala Ala Arg Ala Val Cys Glu Arg His
115 120 125
Ala Thr Leu Arg Lys Ala Pro Pro Pro Glu Gly Gly Met Leu Ala Val
130 135 140
Asn Ala Asp Thr Ala Arg Ala Glu Glu Leu Ile Ala Ser Ala Arg Ala
145 150 155 160
Glu Ala Ser Ala Val Ser Ala Arg Asn Ala Pro Ser Gln Thr Val Val
165 170 175
Ser Gly Thr Glu Ala Asp Leu Val Glu Val Arg Arg Leu Ala Lys Glu
180 185 190
Ala Gly Ile Arg Thr Ser Arg Leu His Val Pro Gly Pro Phe His Val
195 200 205
Pro Gln Leu Ala Asp Ala Ser Ala Leu Tyr Ala Thr Thr Met Arg Thr
210 215 220
Val Arg Met Ser Ala Pro Arg Glu Gly Phe Phe Tyr Ser His Gly Leu
225 230 235 240
Gly Arg Phe Leu Thr Ala His Asp Asp Val Val Asp Leu Met Val Ala
245 250 255
Asp Met Thr Arg Pro Val Arg Phe His Glu Ala Val Arg Ala Met Asn
260 265 270
Ala Glu Gly Val Thr Thr Phe Val Glu Cys Gly Ala Leu Asp Val Leu
275 280 285
Thr Arg Ile Val Ser Gly Thr Leu Pro His Ala Val Thr Leu Ala Pro
290 295 300
Leu Ser Glu Ala Met Thr Val Pro Asp Leu Ser Gly Gln Leu Arg Ser
305 310 315 320
Ala Arg Pro Ser Ala Val Ala Asp Ala Pro Gly Ala Ala Glu Pro Ala
325 330 335
Ala Gly Ala Asp Ala Glu Val Leu Glu Gly Val Arg Ala Val Cys Ala
340 345 350
Glu Ile Leu Glu Tyr Pro Leu Glu Val Val Thr Asp Asp Ala Asp Phe
355 360 365
Gln Ala Asp Leu Gly Val Asp Ser Leu Ala Met Thr Glu Leu Gln Glu
370 375 380
Arg Ala Leu Arg Arg Phe Gly Leu Ala Asp Arg Leu Asn Asp Ala Asn
385 390 395 400
Ala Gly Thr Tyr Ala Thr Val Ser Gly Leu Ala Thr Tyr Ile Thr Gly
405 410 415
Leu Leu Arg Glu Gly Ala Thr Pro Ala Ala Glu Gln Arg
420 425
<210> 95
<211> 1290
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 95
atgaccagtg gggtggcgtt cctcttcccc ggccaggggt cgtacgtgcc cggcgtcttc 60
gccggtatcg gcgcggacgc cgatcggata tcggcacgtg tcgaggagat cgacgcggtc 120
ctggccgagt ttcatttggc tccggtgcgg ccgctgttgt tctcaccgga cgctcccaca 180
ctggcacagt tgctcgcgtc cgatcacgag cgtctcgatg tggccatcct ggcgacctcc 240
atcgccctgg cggagctttt ggactcccgt tacgaggtga ctcccgatca tgtggtcggg 300
cacagtctcg gggagttcgc cgccctggcc gtggcggggg tgttcacccc gggcgaggcc 360
gccagggcgg tctgcgagcg ccacgccacc ctgcgcaagg cgccgccgcc cgagggcggg 420
atgctcgcgg tgaacgcgga caccgcccgt gccgaggagc tgatcgcttc ggcgcgggcc 480
gaggcctcgg ccgtatcggc gcggaacgcc ccgagccaga cggtggtcag cggcacggaa 540
gcggatctgg tggaggtgcg gcggctggcc aaggaggcgg ggatccgcac gtccaggctc 600
catgtccccg gccccttcca cgtaccgcag ttggcggacg cgagtgctct ctacgcgacg 660
acgatgcgga ccgtgcggat gtccgcgccc cgcgagggtt tcttctactc ccacggcctg 720
ggccgcttcc tgaccgcgca cgacgacgtg gtcgatctga tggtggccga catgacccgg 780
ccggtccgtt tccacgaagc ggtgcgcgcg atgaacgccg agggtgtcac gaccttcgtg 840
gagtgcggtg cgctggacgt cctcaccagg atcgtctccg ggacgctgcc ccacgcggtg 900
actctcgcac cgctctccga ggccatgacc gtccccgatc tgtccggcca gctgcggtcg 960
gcgcggccgt cggccgtggc cgacgctccc ggggccgccg agcccgctgc cggggccgac 1020
gcggaggtgc tggagggagt acgcgcggtg tgcgccgaga tcctggagta tccgcttgag 1080
gtggtcaccg acgacgccga cttccaggcc gatctcgggg tcgactcgct ggcgatgacc 1140
gagctacagg aacgcgcact gcgccggttc ggcctggcgg acaggctcaa cgacgccaac 1200
gccggtacgt acgccaccgt ctccggcctc gccacgtaca tcaccgggct gctgcgcgag 1260
ggcgccaccc ccgccgccga acagcggtga 1290
<210> 96
<211> 796
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 96
Val Thr Ser Ser Gly Pro Asp Asp Ala Gly Thr Arg Ala Asp Ala Val
1 5 10 15
Ala Val Val Gly Met Gly Ile Ala Val Pro Gly Ala Cys Asp Thr Asp
20 25 30
Glu Leu Trp Lys Val Leu Ser Gly Asp Arg Pro Val Phe Glu Glu Pro
35 40 45
Gly Asp Arg Tyr Pro Leu Gly Ser Phe Trp Ser Arg Asp His Ala Ala
50 55 60
Glu Asp Arg Gly Tyr Val Arg Thr Ser Gly Phe Leu His Asp Phe Arg
65 70 75 80
Pro His Pro Asp Leu Ala Glu Glu Ile Ala Ala Gly Thr Phe Ser Ala
85 90 95
Ala Asp Gln Asn Pro Val Trp Leu Arg His Cys Leu Leu Arg Ala Arg
100 105 110
Asp Thr Val Thr Ala Arg Ala Thr Asp Arg Tyr Ala Tyr Tyr Val Gly
115 120 125
Ser Ser Ser Leu Val Gly Gln Arg Thr Asp Glu Ala Ala Leu Ala Glu
130 135 140
Ser Val Ala Pro His Leu Ala Glu Arg Leu His Gly Ala Asp Pro Ala
145 150 155 160
Arg Arg Ala Glu Ala Glu Asn Arg Leu Arg Ala Leu Leu Arg Arg His
165 170 175
His Gly His Gly Pro Gly Arg Pro Val Asp Thr Leu Pro His Arg Val
180 185 190
Ala Arg Ala Ala Ala Thr Gly Leu Leu Pro Asp Asp Cys Glu Phe Ser
195 200 205
Val Val Asp Ala Ala Cys Ser Ser Ser Leu Tyr Ala Ile Gly Leu Gly
210 215 220
Ile Ala Ser Leu Leu Ala Gly Glu Cys Asp Ile Ala Tyr Cys Gly Gly
225 230 235 240
Val Ser Gly Val Thr Pro Arg Tyr Asn Val Thr Phe Ser Lys Leu Arg
245 250 255
Gly Leu Ser Pro Gly Gly Asp Val Arg Ala Phe Asp Arg Asp Ala Asp
260 265 270
Gly Thr Leu Phe Ser Asp Gly Ala Gly Ile Val Ala Leu Lys Arg Leu
275 280 285
Asp Arg Ala Val Glu Asp Gly Asp Ala Val Leu Gly Leu Leu Val Gly
290 295 300
Phe Gly Gly Ser Ser Asp Gly Arg Gly Thr Ala Ile Tyr Ala Pro Asn
305 310 315 320
Pro Lys Gly Gln Arg Arg Cys Leu Asp Arg Ala Arg Arg Asn Ala Gly
325 330 335
Leu Ala Ala Asp Asp Val Asp Trp Val Ile Ala His Gly Thr Gly Thr
340 345 350
Ala Val Gly Asp Ala Val Glu Leu Lys Thr Leu Ala Glu Thr Ala Gly
355 360 365
Pro Gly Gly Leu Trp Cys Gly Ser Asn Lys Ser Leu Leu Gly His Thr
370 375 380
Gly Trp Ser Ser Gly Val Val Ser Val Ile His Ala Leu Thr Ala Leu
385 390 395 400
Arg Glu Gly Val Val Pro Ala Gln Arg Arg Phe Thr Ala Pro Gly Leu
405 410 415
Thr Glu Glu Thr Gly Asp Arg Val Arg Val Pro Val Glu Asp Val Pro
420 425 430
Trp Arg Glu Asp Gly Arg Arg Pro Arg Val Ala Gly Val Ser Ala Phe
435 440 445
Gly Phe Gly Gly Ala Asn Ala His Leu Leu Val Ala Asp Arg Thr Pro
450 455 460
Ala Arg Arg Ile Arg Asp Val Arg Pro Pro Glu Ser Asp Pro Val Val
465 470 475 480
Leu Leu Ala Trp Thr Ala His Leu Pro Gly Asp Pro Gly Pro Ala Glu
485 490 495
Val Ala Arg Leu Val Arg Asp Gly His Val Pro Gly Pro Arg Thr Phe
500 505 510
Gly Pro His Tyr Pro Ala Pro Pro Phe Gln Asp Val Arg Leu Pro Pro
515 520 525
Ala Thr Val Arg Ser Thr Asp Ala Gly Gln Leu Met Ala Leu Arg Val
530 535 540
Ala Ser Leu Phe Ser Ala Glu His Gly Glu Leu Trp Asp Pro Val Arg
545 550 555 560
Ala Thr Thr Gly Val Phe Ala Ala Ser Leu Gly Pro Pro Pro Ser Ala
565 570 575
Met Asp His Leu Val Arg Cys His Ala Ala Glu Leu Asp Gly Leu Leu
580 585 590
Asp Gly Pro Asp Arg Ala Ala Phe Thr Asp Trp Leu Gly Glu Leu Arg
595 600 605
Ala Thr Thr Pro Pro Thr Thr Lys Asp Thr Leu Pro Gly Ile Leu Pro
610 615 620
Gly Ile Val Pro Ala Arg Val Ala Asn Arg His Asp Leu Gly Gly Pro
625 630 635 640
Thr Met Leu Val Asp Thr Gly Ala Thr Ser Gly Leu Thr Ala Val His
645 650 655
Thr Ala Ala Arg Tyr Leu Ala Arg Gly Glu Leu Asn Leu Ala Leu Val
660 665 670
Leu Gly Val Ser Ala Thr Ala Arg Pro Glu Phe Ala Arg Phe Met Gly
675 680 685
Val Asp Pro Glu Arg Val Ala Glu Gly Ala Phe Leu Leu Ala Leu Gly
690 695 700
Arg Ala Ser Val Ala Arg Ala His Gly Leu Arg Pro Leu Ala Gly Leu
705 710 715 720
Arg Thr Ala Trp Gly Gly Thr Pro Arg Pro Pro Val Arg Leu Thr Cys
725 730 735
Gly Ala Ala Gly Ala Gly Gln Thr Phe Leu Gly Ala Asp Gly Val Leu
740 745 750
Ala Val Ile Arg Ala Leu His Ile Asp Ala Pro Asp Val Ala Val Gly
755 760 765
Pro Ala Ser Gly Val Pro Gly Pro Val Val Thr Leu Ser Pro Thr Ala
770 775 780
His Gly Ser Pro Arg Arg Gln Thr Arg Thr Ser Arg
785 790 795
<210> 97
<211> 2391
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 97
gtgacctcca gtggcccgga cgacgcgggc acacgcgcgg acgccgtcgc cgtggtgggg 60
atgggcatcg ctgttcctgg ggcctgcgac acggacgagc tgtggaaggt actgagcggg 120
gaccggcccg tgttcgagga gccgggggac cgctatccgc tcggctcctt ctggtcccgg 180
gaccacgccg ccgaggaccg gggctacgtc cgcacgtcgg gcttcctgca cgacttccgg 240
ccgcaccccg acctcgcgga ggagatcgcc gcgggcacct tctcggccgc cgaccagaac 300
ccggtctggc tgcggcactg cctcctgcgg gcccgggaca ccgtcaccgc ccgcgccaca 360
gaccgctacg cgtactacgt cggcagcagc agcctcgtgg ggcagcgcac cgacgaggcg 420
gccctggccg agtccgtcgc cccgcacctc gccgagcgtc tgcacggggc ggaccccgcc 480
cggcgcgccg aggccgagaa ccggctgcgc gccctcttgc ggcgccacca cgggcacggc 540
ccggggcggc cggtggacac gctgccccac cgggtcgcgc gggccgcggc caccgggctg 600
ctcccggacg actgcgagtt ctccgtggtg gacgccgcct gctcgtcctc gctctacgcg 660
atcggcctcg gcatcgcgag tctgctggcc ggcgagtgcg acatcgccta ctgcggcggg 720
gtgtcgggcg tgacaccgcg ctacaacgtc accttctcca aactgcgcgg gctgagcccc 780
ggcggggacg tacgtgcctt cgaccgagac gcggacggaa ccctcttctc cgacggcgcg 840
ggcatcgtcg cgctcaagcg cctggaccgg gccgtcgagg acggcgacgc cgtgctcgga 900
ctcctcgtgg ggttcggcgg ctcctcggac ggcaggggca cggcgatcta cgcccccaat 960
ccgaaggggc agcgccggtg cctcgaccgc gcccggcgga atgcgggact cgccgccgac 1020
gacgtcgact gggtgatcgc gcacggcacg ggcacggcgg tcggcgacgc cgtggaactg 1080
aaaacgctgg ccgagaccgc tggccccggc ggcctctggt gcggttccaa caagtcactg 1140
ctgggtcaca ccggttggag ttccggagtg gtctcggtca tccacgcgct gacggccctg 1200
cgggagggcg tggtacccgc gcagcgccgc ttcaccgcgc ccggcctcac cgaggagacc 1260
ggcgacaggg tacgtgtccc cgtcgaggac gtcccgtggc gcgaggacgg ccggcgtccc 1320
cgcgtcgccg gtgtctccgc ctttgggttc ggcggcgcca acgcccatct gctggtcgcc 1380
gaccgcaccc ccgcgcgacg gatccgcgat gtccggcccc cggagagcga ccctgtggtc 1440
ctcctcgcct ggaccgccca cctgcccggg gacccgggcc ccgcggaggt ggcacggctg 1500
gtgcgtgacg gccacgtgcc ggggccgcgg acgttcgggc cccactatcc ggcgccgccg 1560
ttccaggacg tccgcctgcc gccggccacc gtgcgatcca ccgacgcggg ccagctcatg 1620
gccttgcgcg tggcgtccct tttcagcgcc gagcacggtg agctgtggga tccggtgcgc 1680
gccaccaccg gggtcttcgc cgcttccctc ggtccgccgc cgtccgccat ggaccacctg 1740
gtgcgctgcc acgccgccga gttggacggc ctcctcgacg gccccgaccg cgcggccttc 1800
accgactggc tcggcgaact ccgcgccacg actccgccga ccaccaagga caccctgccg 1860
ggcatcctgc cgggcatcgt cccggcacgc gtcgccaacc gccacgatct cggcggcccc 1920
accatgctgg tggacaccgg tgccaccagc gggctcaccg ccgtgcacac cgcggcgcgg 1980
tatctggccc gtggcgagct caacctcgcc cttgttctcg gtgtcagtgc cacggcccgt 2040
cctgagttcg cccgcttcat gggcgtcgac cccgagcgcg tcgcggaagg cgccttcctc 2100
ctcgccctgg gacgcgcgtc ggtggcccgc gcccacgggc tgaggccgct cgccggcctc 2160
cgtacggcct ggggcggcac gcctcgtccc ccggtgcgcc tcacctgcgg agcggccggt 2220
gcggggcaga ccttcctcgg tgcggacggc gtcctcgccg tgatccgcgc cctgcacatc 2280
gacgcgcccg acgtcgccgt gggccccgcc agtggtgtgc cggggccggt cgtcaccctc 2340
tcccccaccg cccacggctc gccccgcagg cagacaagga ccagccgatg a 2391
<210> 98
<211> 443
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 98
Met Ser His Leu Arg Asp Ala Ala Ala Thr Asp Asp Pro Gln Ala Val
1 5 10 15
Ala Ala Cys Asp Val Pro Ala Gly Tyr Arg Ala Ala Val Val Leu Ala
20 25 30
Ala Asp Gln Gln Ala Val Thr Ala Thr Pro Val Gly Asp Arg Asp Pro
35 40 45
Arg Arg Thr Val His Val Arg Glu Val Ala Thr Pro Gln Leu Gly His
50 55 60
Gly Glu Val Leu Val Ala Thr Met Ala Ser Ser Ile Asn Tyr Asn Thr
65 70 75 80
Val Trp Ser Ala Leu Phe Glu Pro Val Pro Thr Phe Arg Phe Leu Arg
85 90 95
Thr Phe Gly Arg Thr Ser Pro Glu Ala Ala Arg His Asp Leu Pro Tyr
100 105 110
His Val Leu Gly Ser Asp Leu Ser Gly Val Val Leu Arg Thr Gly Pro
115 120 125
Gly Val Arg Glu Trp Lys Pro Gly Asp Glu Val Val Ala His Cys Leu
130 135 140
Gln Pro Asp Leu Gln Thr Pro Gly Gly His Asp Asp Thr Leu Leu Asp
145 150 155 160
Pro Gly Gln Arg Val Trp Gly Tyr Glu Thr Asn Phe Gly Gly Leu Ala
165 170 175
Glu Ile Ser Leu Val Lys Ala Asn Gln Leu Met Pro Lys Pro Ala His
180 185 190
Leu Thr Trp Glu Glu Ala Ala Ser Leu Gly Val Ala Leu Ser Thr Ala
195 200 205
Tyr Arg Gln Leu Val Ser His His Gly Ala Asp Met Lys Gln Gly Glu
210 215 220
Arg Val Leu Ile Trp Gly Ala Ala Gly Gly Val Gly Ala Tyr Ala Thr
225 230 235 240
Gln Leu Ala Leu Asn Gly Gly Ala Val Pro Val Cys Val Val Ser Ser
245 250 255
Gln Ala Lys Ala Asp Leu Cys Arg Arg Met Gly Ala Glu Leu Val Ile
260 265 270
Asp Arg Ala Ala Glu Asn Phe Thr Phe Trp Asp Glu Gln Asp Arg Pro
275 280 285
Arg Leu Ser Glu Trp Ser Arg Phe Arg Ser Ala Val Arg Asn Leu Ala
290 295 300
Gly Asp Asp Pro Ser Ile Val Val Glu His Pro Gly Arg Glu Thr Phe
305 310 315 320
Gly Ile Ser Val Met Ile Thr Ala Arg Gly Gly Ser Val Val Thr Cys
325 330 335
Ala Ser Thr Thr Gly Tyr Gln His Ser Tyr Asp Asn Arg His Leu Trp
340 345 350
Met His Val Lys Arg Ile Ile Gly Ser His Met Ala Asn Tyr Arg Glu
355 360 365
Ala Trp Ala Ala Asn Asp Leu Val Val Arg Gly Ser Ile His Pro Val
370 375 380
Leu Ser Gln Ser Phe Pro Leu Asp Ala Val Gly Glu Ala Thr Arg Ala
385 390 395 400
Val Ala Gly Asn Ser His His Gly Lys Val Gly Val Leu Cys Leu Ala
405 410 415
Asp Arg Pro Gly Met Gly Val Arg Asp His Ala Leu Arg Ala Arg Lys
420 425 430
Leu Asp Arg Ile Asn Leu Phe Gln Lys Gly Arg
435 440
<210> 99
<211> 1332
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 99
atgagtcacc ttcgcgacgc agcggccacg gacgacccgc aggccgtcgc cgcctgcgac 60
gtccccgccg ggtaccgcgc cgccgtcgtc ctcgcggcgg atcagcaggc cgtcaccgcg 120
acgcccgtcg gggacaggga cccccgtagg acggtccatg tgcgggaggt cgccaccccg 180
cagttgggcc acggcgaggt cctcgtcgcc accatggcca gctccatcaa ctacaacacc 240
gtgtggtcgg cgctgttcga gcccgtgccc accttccgct tcctgcgcac gttcggcagg 300
acctcaccgg aggcggcccg gcacgacctg ccctaccacg tactcggctc cgacctctcc 360
ggggtggtgc tgcgtaccgg acccggcgta cgcgaatgga agcccggcga cgaggtcgtc 420
gcgcactgtc tacagccgga cctccagacc cccggtggac acgacgacac tctgcttgac 480
cccgggcagc gggtctgggg gtacgagacg aatttcggcg gcctcgccga aatctccctg 540
gtcaaggcca accagctgat gccgaaaccc gcgcacctca cgtgggagga ggccgcctcg 600
ctgggggtgg cgctctccac cgcctaccgt cagctggtct cccaccacgg ggcggacatg 660
aagcagggcg agcgtgtcct gatctgggga gcggccggcg gcgtcggcgc gtacgcgacc 720
caactggccc tcaacggcgg cgccgtccct gtctgcgtcg tgtcgtcgca ggccaaggcc 780
gacctgtgcc gccggatggg ggcggagctc gtcatcgacc gcgcggccga gaacttcacc 840
ttctgggacg agcaggaccg gccgcgcctc agtgagtgga gccggttccg cagcgccgtc 900
cgcaacctgg cgggggacga cccgagcatc gtcgtcgagc acccgggccg ggagaccttc 960
ggcatcagcg tcatgatcac cgcgcgaggc gggtccgtgg tcacctgcgc ctcgaccacc 1020
ggctatcagc acagctacga caaccgccat ctgtggatgc acgtcaaacg catcatcggg 1080
tcgcacatgg ccaactaccg ggaggcctgg gccgccaacg acctcgtcgt acggggcagc 1140
atccacccgg tgctctcgca gtcctttccc ctcgacgccg tcggggaggc cacccgggcc 1200
gtggccggca acagccacca cggcaaggtc ggggtgctct gcctcgccga ccgacccggc 1260
atgggggtgc gcgaccacgc cctcagggcc cgcaaactcg accggatcaa cctgttccag 1320
aaaggacggt ag 1332
<210> 100
<211> 386
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 100
Val Ser Asp Pro Glu His Leu Asp Thr Val Arg Lys Phe Val Ser Gln
1 5 10 15
Glu Ile Leu Gly Arg Glu Thr His Leu Asp Ser Leu Ala Asp Ala Pro
20 25 30
Leu Ala Leu Tyr Glu Arg Phe Ala Gly Thr Gly Leu Met Asn Trp Trp
35 40 45
Val Pro Glu Glu His Gly Gly Leu Gly Leu Gly Leu Glu Asp Ser Val
50 55 60
Arg Ile Val Ser Glu Leu Ala Tyr Gly Asp Ala Gly Val Ala Phe Thr
65 70 75 80
Leu Phe Leu Pro Ile Leu Thr Thr Ser Met Val Ser Trp Tyr Gly Gly
85 90 95
Thr Glu Leu Lys Glu Lys Tyr Leu Gly Arg Leu Val Ala Gln Arg Gly
100 105 110
Phe Cys Ala Thr Leu Gly Ser Glu His Glu Ala Gly Ser Glu Leu Ala
115 120 125
Lys Ile Ser Thr Met Val Arg Arg Asp Gly Glu Ser Leu Val Leu Asp
130 135 140
Gly Thr Lys Ala Phe Ser Thr Ser Thr Asp Phe Ala Gln Phe Leu Val
145 150 155 160
Val Ile Thr Arg Ser Ala Asp Asp Pro Gly Gln Tyr Leu Ala Val Thr
165 170 175
Val Pro Arg Asp Thr Pro Gly Leu Arg Val Asp Lys Arg Trp Asp Val
180 185 190
Ile Gly Leu Arg Ala Ser Ala Thr Tyr Gln Val Ser Phe Val Asp Cys
195 200 205
Arg Val Pro Ser Asp His Ala Leu Asn Gly Asn Gly Leu Arg Leu Leu
210 215 220
Glu Ile Gly Leu Asn Ala Ser Arg Ile Leu Ile Ala Ala Thr Ala Leu
225 230 235 240
Gly Val Ala Arg Arg Ile Arg Asp Leu Cys Met Glu Tyr Ala Arg Thr
245 250 255
Lys Ser Leu Arg Gly Ala Pro Leu Val Lys Asp Ala Val Phe Val Gly
260 265 270
Arg Leu Gly Gln Phe Glu Met Gln Ile Glu Val Met Ala Thr Gln Cys
275 280 285
Leu Ala Ala Ala Arg Thr Tyr Asp Ala Thr Ala Ala Arg Pro Asp Ala
290 295 300
Ala Arg Thr Leu Leu Arg Gln Gly Ala Gln Lys Ser Ala Leu Ala Ala
305 310 315 320
Lys Met Phe Cys Gly Gln Thr Ala Trp Gln Ile Ala Ser Ala Ala Ser
325 330 335
Glu Met Phe Gly Gly Leu Gly Tyr Thr His Glu Met Pro Ile Gly Lys
340 345 350
Leu Leu Arg Asp Val Arg His Ala Ser Ile Ile Glu Gly Gly Asp Asp
355 360 365
Val Leu Arg Asp Leu Val Phe Gln Arg Phe Val Val Pro Thr Ala Lys
370 375 380
Arg Thr
385
<210> 101
<211> 1161
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 101
gtgagtgacc ccgaacacct ggacactgtg cggaagttcg tctcccagga gatcctgggt 60
cgggaaaccc acctcgactc gctcgcggac gcacctctgg cgctgtacga gcgcttcgcc 120
gggacgggcc tgatgaactg gtgggttccc gaggaacacg gtggcctcgg gctcggtctc 180
gaagacagtg tgcgtatcgt ctccgaactc gcctacgggg acgccggggt ggctttcacc 240
ctgttcctgc ccatcctgac gaccagcatg gtcagctggt acggcggtac ggagctcaag 300
gagaaatacc tcggccgtct cgtggcccag cggggcttct gcgccacgct cggcagcgag 360
cacgaggccg gcagcgagct ggccaagatc tccaccatgg tgcgcaggga cggcgaaagc 420
ctcgtgctcg acggcaccaa ggccttctcc accagcaccg acttcgccca gttcctcgtc 480
gtcatcaccc gctctgcgga cgacccgggc cagtacctgg cggtcactgt ccctcgggac 540
acgccagggc tgcgggtcga caaacgctgg gacgtcatcg gcctgcgggc ctctgcgacg 600
tatcaagtgt cgttcgtcga ctgccgcgtc ccctcggacc acgcgctgaa cggcaacggg 660
ctgcgtctgc tggagatcgg gctcaacgcc agccggatcc tgatcgccgc caccgcgctg 720
ggtgtcgcgc gcaggatccg cgacctgtgc atggagtacg cgaggacgaa gtcgctcagg 780
ggcgcgccgc tcgtgaagga cgcggtgttc gtcggacggc tcggccagtt cgagatgcag 840
atcgaggtga tggccaccca gtgtctcgcg gcggcgcgca cctatgacgc gacggccgcg 900
aggccggacg ccgccaggac gctgctgcgg cagggtgctc agaagtcggc actggccgcg 960
aagatgttct gcgggcagac ggcctggcag atcgcctccg ccgcgtcgga gatgttcggc 1020
ggcctcgggt acacgcacga gatgccgata gggaagctgc tgcgggacgt gcggcatgcc 1080
tcgatcatcg aaggcggcga cgacgtcctg cgtgatctgg tcttccagcg tttcgtcgta 1140
cccaccgcga aacgcacgta g 1161
<210> 102
<211> 47
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 102
Met Ala Asn Gln Val Thr Thr Ser Asp Ala Leu Leu Ala Tyr Val Arg
1 5 10 15
Glu Val Ser Leu Arg Asp Asp Glu Ala Leu Ser Arg Leu Arg Ala Glu
20 25 30
Ser Ala Gly Leu Pro Gly Gly Gly Val Gly Thr Cys Ser Pro Gly
35 40 45
<210> 103
<211> 144
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 103
atggcgaatc aggtgacgac gtccgacgca ctcctcgctt acgtcaggga ggtgtccctc 60
cgcgacgacg aggcgctgag ccggctgcga gcggagtcgg ccgggctgcc gggtggcggt 120
gtggggacgt gctcgccggg ctga 144
<210> 104
<211> 99
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 104
Val Leu Ala Gly Leu Ile Asp Glu Ala Gly Ala Gly Pro Gly Ser Phe
1 5 10 15
Asp Val Val Phe Ile Asp Ala Asp Lys Ala Gly Tyr Pro Ala Tyr Tyr
20 25 30
Glu Ala Ala Leu Pro Leu Val Arg Gly Gly Gly Leu Ile Ile Val Asp
35 40 45
Asn Thr Leu Phe Phe Gly Arg Val Ala Asp Asp Thr Val Gln Asp Pro
50 55 60
Asp Thr Val Ala Val Arg Ala Leu Asn Ala Ala Leu Arg Asp Asp Asp
65 70 75 80
Arg Val Asp Leu Ala Met Leu Thr Thr Ala Asp Gly Ile Thr Leu Leu
85 90 95
Arg Lys Arg
<210> 105
<211> 300
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 105
gtgctcgccg ggctgatcga cgaggcgggc gcgggccccg gttcgttcga cgtcgtgttc 60
atcgacgcgg acaaggcggg ctatccggcg tactacgagg cggcgctgcc gctggtgcgc 120
ggcggcggcc tgatcatcgt cgacaacacc ctgttcttcg ggcgggtggc cgacgacacg 180
gtgcaggacc ctgacacggt cgcggtccgc gcgctcaacg cggcgctgcg cgacgacgac 240
cgggtggacc tggcgatgct cacgacggcc gacggcatca ccttgctgcg gaagcggtga 300
<210> 106
<211> 362
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 106
Met Thr Asp Thr Thr Ile Val Lys Cys Leu Val Trp Asp Leu Asp Asn
1 5 10 15
Thr Leu Trp Arg Gly Thr Val Leu Glu Asp Asp Glu Val Val Leu Thr
20 25 30
Asp Glu Val Arg Glu Val Ile Arg Thr Leu Asp Gly Arg Gly Ile Leu
35 40 45
Gln Ala Val Ala Ser Lys Asn Asp His Asp Leu Ala Trp Arg His Leu
50 55 60
Glu Arg Leu Gly Val Ala Glu Tyr Phe Val Leu Pro His Ile Gly Trp
65 70 75 80
Gly Pro Lys Ser Gln Ser Val Arg Lys Ile Ala Glu Gly Leu Asn Phe
85 90 95
Ala Pro Thr Thr Leu Ala Phe Val Asp Asp Gln Pro Ala Glu Arg Ala
100 105 110
Glu Val Ala Phe His Leu Pro Glu Val Arg Cys Tyr Pro Ala Glu Arg
115 120 125
Val Thr Ala Leu Pro Ala Leu Pro Glu Phe Ser Pro Ser Ala Ser Thr
130 135 140
Val Asp Ser Arg Arg Arg Arg Leu Met Tyr Gln Ala Gly Phe Ala Arg
145 150 155 160
Asp Gln Ala Arg Glu Thr Tyr Ala Gly Pro Asp Asp Asp Phe Leu Arg
165 170 175
Ser Leu Asp Leu Arg Met Thr Ile Ala Pro Ala Gly His Glu Glu Leu
180 185 190
Thr Arg Val Glu Glu Leu Thr Leu Arg Thr Ser Gln Met Asn Ala Thr
195 200 205
Gly Val His Tyr Ser Asp Ala Ala Leu Arg Thr Leu Leu Ala Asp Pro
210 215 220
Ala His Glu Val Leu Val Val Thr Met Gly Asp Arg Phe Gly Pro His
225 230 235 240
Gly Ala Val Gly Ile Val Leu Leu Glu Lys Lys Pro Ser Val Trp His
245 250 255
Leu Lys Leu Leu Ala Thr Ser Cys Arg Val Val Ser Phe Gly Ala Gly
260 265 270
Ala Thr Ile Leu Asn Trp Leu Thr Asp Arg Ala Ala Arg Ala Gly Thr
275 280 285
His Leu Val Ala Asp Phe Arg Arg Thr Glu Arg Asn Arg Val Met Glu
290 295 300
Ile Ala Tyr Arg Phe Ala Gly Phe Ala Glu Ser Asp Cys Val Cys Gly
305 310 315 320
Ser Ala Leu Gly Asp Pro Ala Gly Arg Ile Glu Arg Leu His Leu Glu
325 330 335
Pro Ser Pro Arg Pro Thr Pro Ser Thr Leu Thr Leu Thr Ala Ala Ala
340 345 350
Gly Ile Pro Phe Thr Ala Ser Ala Ala Arg
355 360
<210> 107
<211> 1089
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 107
atgaccgaca cgaccatcgt caagtgcctg gtctgggact tggacaacac attgtggcgg 60
ggcaccgtgc tggaggacga cgaagtggtg ctcaccgacg aggtccgcga ggtgatcagg 120
acgctcgacg gccggggcat cctccaggcg gtggcgagca agaacgacca cgacctggcg 180
tggcggcacc tggaacggct cggcgtggcg gagtacttcg tattgccgca catcgggtgg 240
gggcccaagt cgcagtccgt caggaagatc gccgaagggc tcaacttcgc gccgaccacg 300
ctcgcgttcg tcgacgacca gcccgccgag cgcgccgagg tcgcgttcca cctgccagag 360
gtgcggtgct atccggccga gcgagtgacc gcgctcccgg cgctgccgga gttcagcccg 420
tcggcctcca cggtcgactc gcggcgccgc cgcctcatgt accaggccgg cttcgcgcgc 480
gatcaggcca gggagacgta cgcaggcccc gacgacgact tcctgcgctc cctcgacctg 540
cgcatgacga tcgcacccgc gggccacgag gaactcaccc gtgtcgagga gttgacgctg 600
cggaccagcc agatgaacgc gacaggcgtg cactactccg acgccgcact gcgcacgctg 660
ctcgccgacc ccgcacacga ggtcctcgtc gtcaccatgg gcgaccgttt cggcccgcac 720
ggcgccgtcg gcatcgtcct gctggagaag aagccgtcgg tgtggcacct gaagctgctc 780
gcgacgtcct gccgggtcgt gtcgttcggc gccggtgcga cgatcctcaa ctggctcacg 840
gaccgggccg cacgcgccgg gacccacctg gtggcggact tccggcgcac ggaacgcaac 900
cgcgtgatgg agatcgccta ccggttcgcc ggcttcgcgg agagcgactg cgtgtgcggg 960
tcggcgctgg gtgacccggc agggcgcatc gaacgcctgc acctggagcc ctcgccgcgt 1020
cccacaccca gcacgctgac gctgaccgcc gcggccggca ttccgttcac cgcttccgca 1080
gcaaggtga 1089
<210> 108
<211> 366
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 108
Met Ala Asp Arg Glu Thr Leu Leu Thr Gly Leu Val Gly Asp Arg Ala
1 5 10 15
Ala Glu Trp Asp Thr Ser Gly Glu Leu Pro Arg Asp Leu Leu Val Arg
20 25 30
Leu Gly Ala Asp Gly Leu Leu Cys Ala Glu Val Ala Ala Glu His Gly
35 40 45
Gly Leu Gly Leu Gly Ser Arg Glu Asn Gly Glu Phe Thr Ala His Val
50 55 60
Gly Ser Leu Cys Gly Ser Leu Arg Ser Val Met Thr Ser Gln Gly Met
65 70 75 80
Ala Ala Trp Thr Val Ala Arg Leu Gly Asp Thr Gly Gln Arg Ala Thr
85 90 95
Tyr Leu Lys Glu Leu Thr Ser Gly Lys Leu Ala Ala Val Gly Phe Ser
100 105 110
Glu Arg Gln Ala Gly Ser Asp Leu Ser Ala Met Arg Thr Arg Val Arg
115 120 125
Ile Glu Gly Asp Thr Ala Val Val His Gly His Lys Val Trp Thr Thr
130 135 140
Ala Ala Gly Tyr Ala Asp His Leu Val Val Phe Gly Leu Gln Glu Asp
145 150 155 160
Gly Ser Gly Ala Ala Val Val Val Pro Ala Asp Ala Asp Gly Val His
165 170 175
Val Glu Arg Val Gln Lys Pro Ser Gly Cys Arg Ala Ala Gly His Ala
180 185 190
Asp Leu Arg Leu Asp Gly Val Arg Val Pro Ala Gly Ala Val Leu Ala
195 200 205
Gly Ser Gly Ala Ser Leu Pro Met Leu Val Ala Ala Ser Leu Ala Tyr
210 215 220
Gly Arg Lys Ser Val Ala Trp Gly Cys Val Gly Ile Leu Arg Ala Cys
225 230 235 240
Arg Thr Ala Ala Thr Ala His Ala Arg Thr Arg Glu Gln Phe Gly Arg
245 250 255
Pro Leu Ala Asp His Gln Leu Val Ala Gly His Leu Ala Asp Leu Trp
260 265 270
Thr Ala Glu Gln Val Ala Thr Arg Val Cys Glu Tyr Ala Ser Asp Arg
275 280 285
Trp Asp Glu Gly Ser Pro Glu Val Val Thr Ala Thr Val Leu Ala Lys
290 295 300
His Val Ala Ala Glu Arg Ala Ala Ala Gly Ala Ala Thr Ala Ala Gln
305 310 315 320
Val Leu Ala Ser Ala Gly Ala Thr Glu Gly His Val Val Glu Arg Ala
325 330 335
Tyr Arg Asp Ala Lys Leu Met Glu Ile Ile Glu Gly Ser Ser Glu Met
340 345 350
Cys Arg Met Ile Leu Ala Arg His Ala Leu Ala Leu Pro Ala
355 360 365
<210> 109
<211> 1101
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 109
atggctgacc gtgagacgct gctgaccggc ctcgtcggtg accgggccgc cgagtgggac 60
acgtccggcg aactgccgcg tgacctgctc gtcaggctcg gcgccgacgg cctgctgtgc 120
gccgaggtcg cggccgagca cggcggtctc ggcctcggaa gccgtgagaa cggcgagttc 180
accgcgcacg tcggcagcct ctgcggctcg ctgcgcagcg tcatgacgtc gcaggggatg 240
gccgcgtgga ccgtggcgcg gctcggcgac accggtcagc gggccacgta cctgaaggag 300
ctgaccagcg ggaagctcgc ggcggtcggc ttcagcgagc ggcaggcggg cagcgatctt 360
tcggcgatgc ggacgcgcgt gcggatcgag ggagacaccg ccgtcgtcca cggtcacaag 420
gtctggacga ccgcggccgg atacgcggac cacttggtcg tcttcggcct ccaggaggac 480
ggttccggcg cggcggtggt cgtacccgcc gacgccgacg gcgtacatgt cgagcgtgtc 540
cagaaaccgt cgggttgccg cgccgccggc cacgccgacc tgcgtctcga cggcgtgcgc 600
gtgccggccg gcgcggttct ggcaggctca ggagcgtcgc tgccgatgct cgtcgcggcg 660
tcgctcgcct acggacgcaa gtcggtcgcc tggggctgcg tcgggattct gcgcgcctgc 720
cgaaccgccg cgacggccca tgccaggacc agggagcaat tcggccggcc gctcgccgac 780
catcaactcg tcgccgggca cctcgccgat ctgtggacgg ccgagcaggt cgcgacgcgt 840
gtctgcgagt acgcgagcga ccgctgggac gagggttcgc ccgaggtggt gaccgccacg 900
gtcctcgcca aacacgtcgc cgccgaacga gccgcagcgg gtgccgcgac cgccgcgcag 960
gtcctcgcct ccgcgggcgc gaccgagggg cacgtcgtcg agcgggcgta ccgcgacgcg 1020
aaactcatgg agatcatcga gggcagcagc gagatgtgcc ggatgatact ggcgcggcac 1080
gcgctggcgc tcccggcctg a 1101
<210> 110
<211> 86
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 110
Val Thr Val Pro Val Lys Asp Asp Pro Val Ala Arg Glu Leu Val Ala
1 5 10 15
Phe Leu Glu Asn Lys Thr Arg Ala Pro Trp Ser Val Glu Arg Asp Leu
20 25 30
Phe Ala Glu Gly Gly Leu Ser Ser Leu Phe Ala Leu Glu Leu Val Val
35 40 45
Phe Leu Glu Lys Thr Phe Asp Val Ser Ile Gly Gly Ser Asp Leu Gln
50 55 60
Leu Val Asn Phe Arg Thr Val Val Ser Met Val Glu Leu Val His Arg
65 70 75 80
Leu Lys Asp Gly Asn Gly
85
<210> 111
<211> 261
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 111
gtgacagtcc ccgtcaagga cgaccctgtg gcgcgtgagc tggtcgcgtt ccttgagaac 60
aagaccaggg cgccctggtc ggtggagcgt gacctgttcg cggagggcgg cctctcgtcg 120
ctcttcgcgc tggagctggt ggtcttcctg gagaagacgt tcgacgtcag catcggcggc 180
tccgacctcc agctggtgaa cttccgcacc gtcgtgtcca tggtcgagct cgtccaccgg 240
ctgaaggacg gtaatggctg a 261
<210> 112
<211> 282
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 112
Val Gly His Arg Ile Leu Val Ile Gly Ala Gly Val Met Gly Thr Gly
1 5 10 15
Ile Thr Thr Leu Ala Leu Arg His Gly Val Ser Val Thr Leu Val Asp
20 25 30
Thr Ser Glu Ala Ile Leu Ala Ala Ala Arg Thr Arg Ile Ala Ala Glu
35 40 45
Leu Arg Met Ala Gln Leu Val Ala Gly Pro Ala Glu Thr Asp Pro Gly
50 55 60
Val Leu Asp Thr Ala Thr Ser Ala Leu Pro Ala Ile Gly Gly Ala Asp
65 70 75 80
Ala Val Ile Glu Ala Val Val Glu Asp Ala Ser Val Lys Ala Asp Val
85 90 95
Leu Ala Thr Val Ser Ala Ala Ala Pro Gly Thr Pro Ile Ile Thr Asn
100 105 110
Thr Ser Ser Ile Pro Val Asp Glu Leu Ala Asp Ala Val Lys Arg Pro
115 120 125
Glu Asp Leu Leu Gly Thr His Phe Met Asn Pro Ser Tyr Val Ile Pro
130 135 140
Thr Val Glu Val Ile Arg Gly Pro Arg Ser Gly Glu Ala Ala Met Ala
145 150 155 160
Ala Val Ala Glu Leu Leu Ala Val Leu Gly Arg Lys Pro Ile Val Val
165 170 175
Lys Asp Ala Pro Gly Phe Val Thr Ser Arg Leu Leu His Pro Met Ile
180 185 190
Asn Asp Ala Ala Arg Ile Val Arg Glu Gly Thr Ala Ser Ala Glu Asp
195 200 205
Val Asp Ala Leu Met Thr Gly Cys Leu Gly His Pro Thr Gly Pro Leu
210 215 220
Arg Thr Ala Asp Leu Ile Gly Ile Asp Asn Leu Val Asp Ala Leu Ser
225 230 235 240
Val Leu His Lys Arg Thr Gly Asp Glu Arg Ser Arg Pro Cys Asp Leu
245 250 255
Leu Leu Gly Met Val Arg Asp Gly His His Gly Arg Lys Thr Gly Arg
260 265 270
Gly Phe Tyr Asp Tyr Glu Glu Val Phe Arg
275 280
<210> 113
<211> 849
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 113
gtgggacacc ggattctcgt gatcggcgcg ggggtgatgg gcaccggcat caccacactc 60
gcgctgcgcc acggcgtcag cgtgacgctc gtggacacgt cagaggcgat cctcgcggcg 120
gcgcggaccc ggatcgccgc cgagctgcgg atggcacaac tcgtggccgg gcccgcggag 180
accgaccccg gcgtgctcga tacggcgaca tccgcgctgc ccgcgatcgg cggggccgat 240
gcggtgatcg aagccgttgt cgaggacgcc tcggtcaagg cggacgtact cgccacggtc 300
tcggccgccg cgccgggcac cccgatcatc accaacacct cgtcgatccc ggtcgacgag 360
ctggccgacg cggtgaaacg gccggaggac ctgctcggca cgcacttcat gaatccgtcg 420
tacgtgatcc cgacggtcga ggtgatccgt gggcccagga gcggcgaggc cgccatggcc 480
gccgtcgcgg agctgctcgc ggtactcggc cgcaagccga tcgtcgtcaa ggacgcgccc 540
ggcttcgtca cgagcaggct gctccacccg atgatcaacg acgcggctcg gatcgtacgg 600
gagggcaccg cgtccgccga ggacgtcgac gcgctcatga cgggctgcct cggccacccg 660
acaggtccgc tgcgcaccgc ggacctgatc ggcatcgaca acctcgtcga cgcgctgtcg 720
gtactgcaca agcgcacggg ggacgagcgc agccgcccct gtgacctgct gctcggcatg 780
gtccgcgacg ggcaccacgg ccggaagacc gggcgtggct tctacgacta cgaagaggtg 840
ttccggtga 849
<210> 114
<211> 345
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 114
Met Gln Thr Lys Ile Leu Arg Gln Arg Asp Ile Lys Gln Ile Leu Ser
1 5 10 15
Val Val Gly Arg Asp Ala Ile Met Asp Arg Leu Ile Glu Glu Leu His
20 25 30
Lys Gly Phe Ala Ala Leu Gly Ser Gly Glu Phe Asp Glu Ala Pro Pro
35 40 45
Arg Ser Gly Phe Ala Arg Ser Ala Glu Val Pro Gly Val Ile Glu Phe
50 55 60
Met Pro Tyr Arg Val Pro Gly Val Gly Val Thr Met Lys Thr Ile Ser
65 70 75 80
Tyr Ser Pro His Asn Tyr Gln Arg Phe Arg Leu Pro Thr Val Val Gly
85 90 95
Thr Val Ser Arg Leu Asp Asp Asp Ser Gly Ser Leu Ile Ala Phe Ala
100 105 110
Asp Ala Ala Val Ile Thr Ala Met Arg Thr Gly Ala Val Ser Ala Val
115 120 125
Ala Ser Arg Leu Leu Ala Arg Pro Asp Ser Ser Thr Leu Ala Leu Ile
130 135 140
Gly Ala Gly Ala Gln Ala Val Thr Gln Ala His Ala Leu Ser Arg Val
145 150 155 160
Leu Pro Met Glu Arg Ile Leu Val Ser Asp Ile Asp Gln Gly His Ala
165 170 175
Glu Ser Phe Ala Gly Arg Val Ala Phe Leu Gly Leu Thr Val Glu Val
180 185 190
Thr Asp Pro Glu Ala Ala Val Ala Ala Ala Asp Val Leu Thr Thr Val
195 200 205
Thr Ser Val Pro Ala Gly Arg Gly Pro Val Val Pro Pro Glu Pro Arg
210 215 220
Leu Pro His Leu His Val Asn Ala Val Gly Ala Asp Glu Pro Gly Lys
225 230 235 240
Thr Glu Leu Pro Arg Val Leu Leu Glu Ser Ala Phe Ile Cys Val Asp
245 250 255
His Pro Gly Gln Ala Arg Thr Glu Gly Glu Phe Gln Gln Phe Pro Asp
260 265 270
Arg Glu Leu Gly Pro Ser Leu Ala Ser Leu Cys Ala Ala Pro Ser Thr
275 280 285
Ala Ala Ala His Ile Asp Ser Leu Ser Val Leu Asp Ser Thr Gly Ser
290 295 300
Ala Phe Ala Asp His Ile Ala Phe Asp Val Leu Leu Gly Phe Ala Asp
305 310 315 320
Glu Leu Gly Leu Gly Arg Lys Ala Ala Ile Gly Ala Thr Pro Glu Asp
325 330 335
Val Leu Asp Pro Tyr Ser Leu Pro Trp
340 345
<210> 115
<211> 1038
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 115
atgcagacca aaatcctgcg tcagcgtgac atcaagcaga ttctctccgt ggtcggccgc 60
gacgcgatca tggaccggct gatcgaagag ctgcacaaag gcttcgccgc actcggcagc 120
ggagagttcg acgaggcgcc gccacgcagt gggttcgccc gcagcgctga agtgcccggc 180
gtcatcgagt tcatgccgta ccgggtgccc ggtgtcggcg tgaccatgaa gacgatctcg 240
tacagtccgc acaactatca acgattccgg ctgccgacgg tcgtcggcac ggtgtcgcgc 300
ctcgacgacg acagcggcag cctgatcgcg ttcgccgacg cggcagtgat caccgcgatg 360
cgtaccggcg cggtctccgc ggtcgcgagc cggctgctgg ccaggcccga cagttccacg 420
ctcgcgctga tcggcgcggg tgcccaggcg gtgacccagg cgcacgcgct cagcagggtc 480
ctgccgatgg agcggatcct ggtcagcgac atcgaccagg gccacgcgga gtccttcgcg 540
ggccgcgtcg cgttcctcgg gctgacggtc gaagtcacgg atccggaggc ggcggtcgcc 600
gcggcggatg tcctgaccac cgtcacctcg gtgcccgcgg gccggggccc ggtcgtgcct 660
cccgagccgc gactgccgca cctgcacgtc aacgcggtgg gcgccgacga acccggcaag 720
accgagttgc ccagggtcct gctggagtcc gcgttcatct gtgtcgacca ccccgggcag 780
gcccgcacgg aaggcgaatt ccagcagttc cccgaccgtg agctgggccc gtcgctggcg 840
agcctgtgcg cggcgccgag caccgcggcg gcccacatcg acagcctgag cgtcctcgac 900
tcgaccggca gcgccttcgc cgaccacatc gcgttcgacg tgctgctcgg cttcgcggac 960
gaactcggtc tcggccgcaa ggccgcgatc ggggcgacgc ctgaggacgt gctcgacccg 1020
tactcgctgc cgtggtga 1038
<210> 116
<211> 4932
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 116
Met Ala Arg Ala Glu Ser Ile Arg Pro Leu His Glu Leu Leu Arg Val
1 5 10 15
Asn Ser Glu Arg Arg Gly Asp Arg Val Ala Tyr Thr Asp Ser Arg Arg
20 25 30
Ala Val Thr Tyr Ala Gln Leu His Ile Arg Ser Gly Arg Ile Ala Gly
35 40 45
His Leu Thr Ala Ser Gly Val Gly Arg Gly Asp Arg Val Ala Leu Leu
50 55 60
Leu Gly Asn Arg Ile Glu Thr Ile Glu Ala Tyr Leu Ala Ala Ala Arg
65 70 75 80
Ala Ala Ala Val Ala Val Pro Leu Asn Pro Asp Ala Gly Asp Ala Glu
85 90 95
Leu Ala His Phe Leu Ser Asp Ser Gly Ala Thr Val Leu Val Thr Asp
100 105 110
Asp Leu His Leu Asp Gln Val Arg Arg Val Gly Thr Arg Ala Thr Val
115 120 125
Val Leu Ala Gly Arg Arg Glu Gln Gly Cys Ile Ala Tyr Glu Asp Leu
130 135 140
Ala Gly Thr Glu Pro Pro Cys Pro Pro Cys Asp Asp Leu Gly Leu Asp
145 150 155 160
Glu Pro Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys
165 170 175
Gly Val Val Ser Ala Gln Arg Ser Gly Leu Trp Ser Ala Lys Tyr Cys
180 185 190
Asp Val Pro Ser Trp Gln Leu Thr Glu Asp Asp Glu Leu Leu Trp Pro
195 200 205
Ala Pro Leu Phe His Ser Leu Gly His His Leu Cys Leu Leu Ala Val
210 215 220
Leu Thr Val Gly Ala Ser Ala Arg Ile Leu Gly Gly Phe Val Ala Arg
225 230 235 240
Asp Val Leu Asp Ala Leu Ala Glu His Pro Cys Thr Val Leu Val Gly
245 250 255
Val Pro Thr Met Tyr Arg Tyr Leu Leu Gly Ala Val Ser Gly Glu Ala
260 265 270
Gly Gly Val Ser Gly Gly Thr Gly Thr Gly Ala Val Ser Gly Gly Thr
275 280 285
Gly Ala Val Ser Gly Gly Ala Glu Thr Arg Ala Leu Arg Val Ala Leu
290 295 300
Val Ala Gly Ser Thr Ser Pro Ala Ser Leu Thr Ala Gly Phe Glu Ala
305 310 315 320
Ala Phe Gly Val Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr
325 330 335
Gly Ser Leu Thr Ala Asn Thr Leu Thr Asp Ala Arg Val Pro Gly Ser
340 345 350
Cys Gly Leu Pro Val Pro Gly Leu Ser Leu Arg Phe Val Asp Pro Val
355 360 365
Ser Gly Ala Asp Val Ala Arg Gly Asp Glu Gly Glu Leu Trp Ala Ser
370 375 380
Gly Pro Ser Leu Met Leu Gly Tyr His Ala Gln Ala Glu Ala Thr Ala
385 390 395 400
Gln Val Leu Val Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Gln
405 410 415
Ala Glu Thr Gly His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile
420 425 430
Ile Arg Gly Gly Glu Asn Ile His Pro Arg Glu Ile Glu Ser Val Ala
435 440 445
Gln Glu Val Pro Gly Val Arg Asp Ala Ala Ala Ala Gly Arg Pro His
450 455 460
Pro Val Leu Gly Glu Ile Pro Val Leu Tyr Val Val Pro Glu Gly Pro
465 470 475 480
Arg Val Pro Ala Glu Ala Ile Leu Ala Glu Cys Arg Ser Gln Leu Ser
485 490 495
Tyr Phe Lys Val Pro Asp Glu Ile Leu His Val Thr Thr Val Pro Arg
500 505 510
Thr Ala Ser Gly Lys Val Arg Arg Gly Glu Leu Ala Ala Leu Pro Ala
515 520 525
Arg Leu Val Ala Thr Gly Ser Gly Glu Ala Thr Leu Cys Glu Val Ile
530 535 540
Trp Glu Arg Arg Asp Leu Pro Asp Thr Val Pro Glu Leu Arg Asp Leu
545 550 555 560
Pro Gly Thr Val Ser Gln Gly Arg Thr Val Val Thr Arg Arg Ala Ile
565 570 575
Gly Val Gly Pro Ala Glu Val Pro Asp Ala Asp Gln Ala Ala Leu Trp
580 585 590
Asp Glu Ala Leu Arg Arg Gln Ala Ala Glu Pro Gly Ser Phe Val Leu
595 600 605
Val Asp Thr Asp Gly Asp Gly Ser Asp Gly His Asp Gly Asp Gly Asp
610 615 620
Gly Gly Gly Gly Gly Gly Gly Asp Gly Gly Gly Asp Gly Asp Gly Gly
625 630 635 640
Ala Glu Arg Val Ala Ala Ala Ala Ser Leu Gly Glu Pro Gln Val Ala
645 650 655
Leu Arg Ala Gly Val Ala Tyr Val Pro Arg Leu Val Pro Ala Asp Thr
660 665 670
Thr Pro Leu Pro Thr Ala Arg Trp Ala Leu Arg Pro Pro Ala Ser Gly
675 680 685
Ala Leu Arg Asp Leu Ala Val Ala Pro Leu Gly Thr Ala Ser Asp Ala
690 695 700
Ala Pro Arg Pro Leu Ala Val Gly Glu Val Arg Val Asp Val His Ala
705 710 715 720
Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu Gly Thr Tyr Pro
725 730 735
Gly Asp Gly Glu Met Gly Gly Glu Ala Ala Gly Ile Val Thr Glu Val
740 745 750
Gly Pro Gly Val Glu Asp Leu Ala Pro Gly Asp Arg Val Phe Gly Leu
755 760 765
Val Arg Asp Ala Phe Arg Arg Ser Val Val Ala Asp Arg Arg Leu Val
770 775 780
Ala Arg Ala Pro Arg Gly Trp Ser Phe Pro Val Ala Ala Ser Val Pro
785 790 795 800
Ile Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Ala Gly Ala Val
805 810 815
Arg Pro Gly Gln Lys Val Leu Ile His Ala Ala Thr Gly Gly Val Gly
820 825 830
Met Ala Ala Thr Arg Ile Ala Arg His Leu Gly Ala Glu Val Tyr Ala
835 840 845
Thr Ala Ser Pro Ala Lys Gln His Leu Leu Tyr Ala Asp Gly Phe Asp
850 855 860
Thr Asp His Val Ala Asn Ser Arg Thr Thr Gly Phe Ala Asp Val Phe
865 870 875 880
Pro Pro Val Asp Val Val Leu Asn Ser Leu Thr Gly Asp Leu Leu Asp
885 890 895
Ala Ser Val Ala Leu Leu Ala Pro Gly Gly Arg Phe Val Glu Met Gly
900 905 910
Lys Thr Asp Ile Arg His Asp Val Gln Gln Pro Phe Asp Leu Ser Asp
915 920 925
Val Asp Pro Ala Arg Leu Arg Asp Ile Leu Asp Leu Leu Leu Gly Leu
930 935 940
Phe Asp Gly Asp Glu Leu Arg Pro Leu Pro Val Arg Pro Trp Asp Ile
945 950 955 960
Arg Arg Ala Arg Asp Ala Phe Ala Trp Met Ser Gln Ala Arg His Thr
965 970 975
Gly Lys Met Val Leu Thr Val Pro Gln Pro Leu Gly Pro Arg Ser Ser
980 985 990
Ile Leu Val Thr Gly Asp Gly Ala Asp Ala Val Ala Asp Leu Leu Arg
995 1000 1005
Glu Glu Thr Gly Leu Gly His Val Ala Thr Gly Val Ala Glu Ala
1010 1015 1020
Ala Gly Ala Ala Gly Ala Glu Gly Ala Gly Gly Val Ala Gly Ala
1025 1030 1035
Thr Glu Asp Ala Glu Ala Thr Ala Val Thr Gly Glu Pro Glu Thr
1040 1045 1050
Glu Glu Arg Gly Asn Ala Ser Ala Leu Val His Val Leu Leu Gly
1055 1060 1065
Asp Pro Ala Ala Ala Asp Ala Tyr Ala Arg Ser Arg Ala Ser Glu
1070 1075 1080
Gly Leu Pro Ile Val Thr Val His Gly Leu Pro Gly Ile Glu Gln
1085 1090 1095
Ala Ala Leu Thr Ser Glu Leu Leu Glu Lys Ala Ile Glu Gly Gly
1100 1105 1110
Gly Ser Tyr Val Val Thr Arg Pro Asp Ser Ser Gly Ala Arg Ala
1115 1120 1125
Glu Ala Met Ala Gly Ala Thr Pro Pro Ile Leu Thr Arg Leu Thr
1130 1135 1140
Gly Pro Ala Gly Leu Thr Gly Pro Ala Gly Pro Ala Gly Pro Ala
1145 1150 1155
Gly Gln Val Arg Pro Gly Ala Gly Gly Pro Glu Trp Ala Ser Arg
1160 1165 1170
Leu Ala Ala Ala Asp Ala Asp Arg Glu Thr Val Met Leu Gly Leu
1175 1180 1185
Val Arg Asp Ser Leu Ala Thr Val Leu Gly Leu Pro Gly Ala Glu
1190 1195 1200
His Cys Ala Pro Asp Arg Thr Phe Arg Glu Asn Gly Leu Asp Ser
1205 1210 1215
Leu Thr Thr Val Glu Phe Ala Asn Ile Val Ala Ser Arg Ile Gly
1220 1225 1230
Ala Arg Val Pro Ala Ser Thr Ala Phe Asp His Pro Thr Pro Arg
1235 1240 1245
Ser Phe Ala Ala His Leu Ala Gly Ser Ala Ala Ala Ala Pro Ala
1250 1255 1260
Ala Arg Ala Thr Val Asp Ser Gly Glu Pro Val Ala Ile Val Gly
1265 1270 1275
Met Ala Cys Arg Leu Pro Asp Gly Val Ser Ala Thr Cys Cys Glu
1280 1285 1290
Glu Leu Trp His Leu Val Ala Ser Gly Thr Asp Ala Ile Thr Glu
1295 1300 1305
Phe Pro Gly Asp Arg Gly Trp Asp Val Asp Ala Leu Val Asp Pro
1310 1315 1320
Asp Pro Asp Lys Ala Gly Arg Ser Thr Thr Arg His Gly Gly Phe
1325 1330 1335
Leu Ala Glu Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
1340 1345 1350
Pro Asn Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu
1355 1360 1365
Glu Thr Ser Trp Glu Ala Phe Glu Cys Ala Gly Ile Val Pro Asp
1370 1375 1380
Thr Leu Arg Glu Ser Asp Thr Gly Val Phe Met Gly Ala Phe His
1385 1390 1395
Gln Gly Tyr Gly Thr Gly Arg Asp Leu Gly Gly Leu Gly Val Thr
1400 1405 1410
Ala Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr
1415 1420 1425
Gly Leu Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser
1430 1435 1440
Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Ser Gly
1445 1450 1455
Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr
1460 1465 1470
Pro Gln Ser Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro
1475 1480 1485
Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr Gly
1490 1495 1500
Phe Ala Glu Gly Val Gly Val Leu Val Leu Glu Arg Leu Ser Asp
1505 1510 1515
Ala Glu Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser
1520 1525 1530
Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn
1535 1540 1545
Gly Val Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
1550 1555 1560
Gly Leu Ser Gly Gly Asp Val Asp Val Val Glu Ala His Gly Thr
1565 1570 1575
Gly Thr Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
1580 1585 1590
Thr Tyr Gly Gln Gly Arg Glu Val Pro Leu Leu Leu Gly Ser Val
1595 1600 1605
Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly
1610 1615 1620
Val Ile Lys Met Val Met Ala Met Arg Tyr Gly Val Val Pro Arg
1625 1630 1635
Thr Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Ser Ala
1640 1645 1650
Gly Ala Val Glu Leu Leu Thr Glu Ala Arg Pro Trp Pro Gly Ser
1655 1660 1665
Gly Arg Ser Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly
1670 1675 1680
Thr Asn Ala His Val Ile Leu Glu Gly Val Pro Glu Leu Pro Pro
1685 1690 1695
Gly Gly Arg Thr Ser Pro Asp Glu Gly Ala Val Ser Gly Leu Val
1700 1705 1710
Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Ser Leu
1715 1720 1725
Val Glu Arg Leu Asp Val Tyr Val Arg Gly Gly Ser Ser Val Gly
1730 1735 1740
Gly Gly Leu Gly Gly Val Ala Asp Gly Leu Val Arg Gly Arg Ala
1745 1750 1755
Val Phe Gly His Arg Ala Val Leu Leu Gly Glu Ser Arg Val Thr
1760 1765 1770
Gly Val Ala Val Asp Gly Leu Arg Thr Val Phe Val Phe Pro Gly
1775 1780 1785
Gln Gly Ser Gln Trp Val Gly Met Gly Val Ala Leu Met Ser Ala
1790 1795 1800
Ser Glu Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu
1805 1810 1815
Glu Pro Phe Thr Gly Trp Asp Val Arg Asp Met Leu Ser Gly Pro
1820 1825 1830
Glu Val Leu Glu Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala
1835 1840 1845
Val Ala Val Ser Leu Ala Ala Leu Trp Arg Ala His Gly Val Val
1850 1855 1860
Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala
1865 1870 1875
Cys Val Ala Gly Ala Leu Thr Leu Glu Asp Gly Ala Arg Ile Val
1880 1885 1890
Ala Arg Arg Ser Arg Ser Ile Ala Ala Arg Leu Ala Gly His Gly
1895 1900 1905
Ala Met Ala Ser Ile Ala Val Pro Ala Ala Glu Val Glu Thr Val
1910 1915 1920
Glu Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ser Thr Val
1925 1930 1935
Ile Ala Gly Asp Pro Glu Ala Val Glu Gln Val Leu Ala Arg Tyr
1940 1945 1950
Glu His Asp Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala
1955 1960 1965
Ser His Thr Pro His Val Glu Ala Ile Glu Asp Glu Leu Ala Glu
1970 1975 1980
Ala Leu Glu Gly Val Ser Ala Gln Ala Pro Thr Ile Pro Trp Trp
1985 1990 1995
Ser Thr Leu Asp Ser Gly Trp Ile Ser Glu Pro Val Glu Asp Gly
2000 2005 2010
Tyr Trp Tyr Arg Asn Leu Arg Arg Pro Val Ala Met Asp Thr Ala
2015 2020 2025
Val Arg Glu Leu Asp Gly Ser Leu Phe Leu Glu Cys Ser Ala His
2030 2035 2040
Pro Val Leu Leu Pro Ala Leu Asp Gln Pro His Thr Val Ala Ser
2045 2050 2055
Leu Arg Thr Gly Asp Gly Gly His Pro Arg Phe Val Thr Ala Leu
2060 2065 2070
Ala Glu Ala Trp Thr Gln Gly Ala Pro Val Asp Trp Thr Thr Leu
2075 2080 2085
Ile Ala Pro Val Thr Pro Thr Ala Arg Leu Leu Asp Leu Pro Thr
2090 2095 2100
Tyr Pro Phe Asp His Lys Arg Tyr Trp Ile Glu Ala Thr Thr Thr
2105 2110 2115
Pro Gly Leu Thr Asp Thr Ala His Pro Met Leu Ala Ala Thr Thr
2120 2125 2130
Ala Leu Pro Thr Thr Asp Gly Thr Val Leu Thr Gly Arg Ile Ser
2135 2140 2145
Leu Arg Thr His Pro Trp Leu Ala Asp His Thr Ile Gln Asp Thr
2150 2155 2160
Val Leu Leu Pro Gly Thr Ala Phe Leu Glu Leu Ala Val Arg Ala
2165 2170 2175
Gly Asp Glu Thr Gly Cys Asp Thr Ile Asp Glu Leu Val Ile Glu
2180 2185 2190
Thr Pro Leu Thr Leu Pro Ala Thr Thr Ala Val Asp Leu Thr Leu
2195 2200 2205
Thr Ile Asp Pro Pro Asp Thr Thr Gly His His Pro Leu Thr Ile
2210 2215 2220
His Ala Arg Pro Glu Gly Thr His Thr Trp Thr Arg His Ala Thr
2225 2230 2235
Gly Thr Leu Ser Arg Ala Gly Asn Gly Asp Gly Asp Ile Ala Ala
2240 2245 2250
Gly Tyr Pro Ser Ala Trp Pro Pro Pro Glu Ala Gln Pro Val Asp
2255 2260 2265
Val Thr Gly Phe Tyr Glu Arg Leu Ala Glu Ile Gly Tyr Ile Tyr
2270 2275 2280
Gly Pro Ala Phe Arg Gly Leu Arg Ala Ala Trp Arg Ser Gly Glu
2285 2290 2295
Thr Leu Tyr Ala Glu Val Glu Ile Thr Gly Glu Glu Ala Glu Gln
2300 2305 2310
Thr Glu Gln Ala Gly Asp Ala Ser Ser Tyr Gly Val His Pro Ala
2315 2320 2325
Leu Leu Asp Ala Ala Leu His Val Thr Cys Leu Pro Leu Leu Thr
2330 2335 2340
Gly Arg Gly Ser Glu Gln Glu Pro Glu Ser Arg Ser Glu Ser Glu
2345 2350 2355
Pro Glu Ser Ala Ser Glu Pro Glu Val Lys Leu Pro Phe Ser Trp
2360 2365 2370
Ser Gly Val Arg Phe His Thr Thr Gly Ala Thr Thr Leu Arg Val
2375 2380 2385
Ala Ile Thr Gln Gly Pro Asn Gly Val Ala Val His Ala Ala Asp
2390 2395 2400
Pro Ala Gly His Pro Val Val Thr Val Ser Glu Leu Ala Ala Arg
2405 2410 2415
Pro Val Asn Val Arg Thr Asp Ala Tyr Thr Asp Ala Thr Val Arg
2420 2425 2430
Asp Ser Leu Tyr His Leu Ser Trp Thr Glu Leu Pro Thr Pro Ala
2435 2440 2445
Ala Ala Thr Val Gly Pro Gly Pro Thr Ala Asp Pro Ala Pro Thr
2450 2455 2460
Val Asp Pro Ala Pro Ser Ala Gly Pro Gly Ser Thr Ala Gly Pro
2465 2470 2475
Gly His Ala Asp Glu Val Gln Val Val Ser Ala Ile Pro Glu Pro
2480 2485 2490
Asp Ala Asp Val Leu Asp Glu Thr Tyr Arg Leu Thr Ala Leu Val
2495 2500 2505
Leu Gly Glu Leu His Arg Val Val Ala Asp Asp Ser Leu Ala Ala
2510 2515 2520
Thr Thr Leu Val Val Arg Ile Asp Ala Gly Pro Thr Gly Gly Ala
2525 2530 2535
Val Ala Gly Leu Val Arg Ser Ala Gln Ala Glu His Pro Gly Arg
2540 2545 2550
Phe Val Leu Val Glu Thr Gly Gly Asp Thr Pro Phe Glu Thr Leu
2555 2560 2565
Ala Ala Ala Thr Thr Leu Ala Glu Pro Tyr Val Arg Val Thr Asp
2570 2575 2580
Gly Arg Tyr Glu Ala Pro Arg Leu Arg Arg Thr Ala Ala Thr Arg
2585 2590 2595
Thr His Glu Pro Leu Leu Asp Pro Glu Gly Thr Val Val Ile Thr
2600 2605 2610
Gly Gly Ser Gly Val Leu Ala Gly Leu Leu Ala Arg Arg Leu Val
2615 2620 2625
Ala Glu His Gly Ala Arg His Leu Leu Leu Leu Ser Arg Ser Glu
2630 2635 2640
Pro Pro Val Asp Thr Pro Gly Val His Ile Arg Cys Asp Val Ser
2645 2650 2655
Asp Lys Asp Gln Leu Ala Ala Ala Leu Ala Ala Ala Asp Arg Pro
2660 2665 2670
Leu Thr Ala Val Phe His Thr Ala Ala Val Leu Asp Asp Gly Val
2675 2680 2685
Ile Ala Ala Leu Thr Pro Glu Arg Leu Ala Thr Thr Leu Arg Pro
2690 2695 2700
Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Arg Gly Ala
2705 2710 2715
Asp Leu Arg Ala Phe Val Leu Tyr Ser Ser Val Ala Gly Ile Leu
2720 2725 2730
Gly Gly Arg Gly Gln Ala Asn Tyr Ser Ala Ala Asn Gly Phe Leu
2735 2740 2745
Asp Gly Leu Ala Ala Ser Arg Arg Ala Glu Gly Leu Pro Ala Leu
2750 2755 2760
Ser Leu Ala Trp Gly Leu Trp Ala Asp Asp Ser Gly Leu Thr Gly
2765 2770 2775
Thr Met Ser Gly Thr Asn Arg Thr Arg Val Arg Arg Gly Gly Phe
2780 2785 2790
Arg Pro Met Arg Ala Gly Leu Ala Leu Arg Leu Leu Glu Thr Ala
2795 2800 2805
Ala Gly Thr Gly Ala Ala Phe Ala Val Ala Ala Thr Met Asp Pro
2810 2815 2820
Asn Ala Gln Ala Ser Pro Leu Phe Met Gly Leu Arg Arg Ser Val
2825 2830 2835
Pro Arg Arg Ala Ala Ala Thr Thr Val Pro Leu Ala Glu Arg Leu
2840 2845 2850
Gly Ala Met Thr Gly Ala Asp Arg Asp Ala Ala Leu Leu Ala Leu
2855 2860 2865
Val Arg Asp Cys Ala Ala Ala Val Leu Gly His Val Asp Ala Thr
2870 2875 2880
Ala Val Pro Ala Asp Ala Ala Phe Lys Asp Leu Gly Val Asp Ser
2885 2890 2895
Leu Thr Ala Val Glu Leu Arg Asn Arg Leu Ala Thr Ala Thr Gly
2900 2905 2910
Val Arg Leu Pro Ala Thr Leu Ala Phe Asp His Pro Thr Pro Arg
2915 2920 2925
Ala Ile Ala Ser Arg Leu Asp Glu Thr Met Ala Gly Ser Thr Val
2930 2935 2940
Pro Ala Ala Val Pro Ala Ala Ala Ser Val Thr Ala Ala Thr Arg
2945 2950 2955
Asp Asp Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly
2960 2965 2970
Gly Val Ala Ser Pro Asp Asp Leu Trp Arg Met Leu Asp Asn Gly
2975 2980 2985
Gly Asp Ala Val Thr Gly Phe Pro Ala Asp Arg Gly Trp Asp Pro
2990 2995 3000
Ser Gly Leu Thr Gly Gly Pro Asp Ala Asp Arg Gly Gly Phe Leu
3005 3010 3015
Ser Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
3020 3025 3030
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Ile Met Leu Glu
3035 3040 3045
Thr Thr Trp Glu Ala Phe Glu Ser Ala Gly Ile Val Pro Ala Thr
3050 3055 3060
Leu Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Ser Tyr
3065 3070 3075
Gly Tyr Gly Val Gly Ala Asp Met Gly Gly Phe Gly Ser Ile Gly
3080 3085 3090
Val Gln Pro Ser Val Leu Thr Gly Arg Ile Ser Tyr Phe Tyr Gly
3095 3100 3105
Leu Gln Gly Pro Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser
3110 3115 3120
Leu Val Ala Leu His Gln Ala Gly Tyr Ala Leu Arg His Gly Glu
3125 3130 3135
Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro
3140 3145 3150
Thr Gly Phe Val Glu Phe Gln Gln Gln Gly Gly Leu Ser Pro Asp
3155 3160 3165
Gly Arg Cys Arg Ala Phe Ala Asp Thr Ala Asn Gly Thr Gly Trp
3170 3175 3180
Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala
3185 3190 3195
Glu Arg Lys Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala
3200 3205 3210
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly
3215 3220 3225
Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly
3230 3235 3240
Leu Ser Gly Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly
3245 3250 3255
Thr Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr
3260 3265 3270
Tyr Gly Gln Gly Arg Glu Val Pro Leu Leu Leu Gly Ser Leu Lys
3275 3280 3285
Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ala Gly Val
3290 3295 3300
Ile Lys Met Val Met Ala Met Arg Tyr Gly Val Val Pro Arg Thr
3305 3310 3315
Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Ser Val Gly
3320 3325 3330
Ala Val Glu Leu Leu Thr Glu Ala Arg Pro Trp Pro Gly Ser Gly
3335 3340 3345
Arg Ser Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr
3350 3355 3360
Asn Ala His Val Ile Leu Glu Gly Val Pro Glu Leu Pro Pro Gly
3365 3370 3375
Gly Arg Thr Ala Pro Asp Glu Gly Ala Val Ser Gly Leu Val Pro
3380 3385 3390
Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Ser Leu Val
3395 3400 3405
Glu Arg Leu Asp Val Tyr Val Arg Gly Gly Leu Ser Val Gly Gly
3410 3415 3420
Gly Leu Gly Gly Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val
3425 3430 3435
Phe Gly His Arg Ala Val Leu Leu Gly Glu Ser Arg Val Ala Gly
3440 3445 3450
Val Ala Val Asp Gly Leu Arg Thr Val Phe Val Phe Pro Gly Gln
3455 3460 3465
Gly Ser Gln Trp Val Gly Met Gly Val Ala Leu Met Ala Ala Ser
3470 3475 3480
Glu Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu Glu
3485 3490 3495
Pro Phe Ser Gly Trp Asp Val Arg Asp Met Leu Ser Gly Pro Glu
3500 3505 3510
Val Leu Glu Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala Val
3515 3520 3525
Ala Val Ser Leu Ala Ala Leu Trp Arg Ala His Gly Val Val Pro
3530 3535 3540
Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
3545 3550 3555
Val Ala Gly Ala Leu Thr Leu Glu Asp Gly Ala Arg Ile Val Ala
3560 3565 3570
Arg Arg Ser Arg Thr Ile Ala Ala Arg Leu Ala Gly His Gly Ala
3575 3580 3585
Met Ala Ser Ile Ala Leu Ser Ala Ser Glu Val Glu Thr Val Glu
3590 3595 3600
Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ser Thr Val Ile
3605 3610 3615
Ala Gly Asp Pro Glu Ala Val Glu Gln Val Leu Ala Arg Tyr Glu
3620 3625 3630
His Asp Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser
3635 3640 3645
His Thr Pro His Val Glu Ala Ile Glu Asp Glu Leu Ala Glu Ala
3650 3655 3660
Leu Glu Gly Ile Thr Ser Arg Ala Pro Thr Ile Pro Trp Trp Ser
3665 3670 3675
Thr Leu Asp Ser Gly Trp Ile Ser Glu Pro Val Glu Asp Gly Tyr
3680 3685 3690
Trp Tyr Arg Asn Leu Arg Trp Pro Val Ala Met Asp Thr Ala Val
3695 3700 3705
Arg Glu Leu Asp Gly Ser Leu Phe Leu Glu Cys Ser Ala His Pro
3710 3715 3720
Val Leu Leu Pro Ala Leu Asp Gln Pro His Thr Val Ala Ser Leu
3725 3730 3735
Arg Thr Gly Asp Gly Gly His Pro Arg Phe Val Thr Ala Leu Ala
3740 3745 3750
Glu Ala Trp Thr Gln Gly Ala Pro Val Asp Trp Thr Thr Leu Ile
3755 3760 3765
Ala Pro Val Thr Pro Thr Ala Arg Leu Leu Asp Leu Pro Thr Tyr
3770 3775 3780
Pro Phe Asp His Lys Arg Phe Trp Leu Arg Pro Val Leu Pro Gly
3785 3790 3795
Gly Glu Gly Ile Gly His Pro Leu Leu Ser Ser Ala Val Val Leu
3800 3805 3810
Pro Gly Ser Asp Gly Val Val Leu Thr Gly Arg Leu Ser Leu Ala
3815 3820 3825
Thr His Ser Trp Leu Ala Asp His Arg Val Trp Asp Thr Val Leu
3830 3835 3840
Leu Pro Gly Thr Ala Phe Leu Glu Leu Val Val Arg Ala Gly Asp
3845 3850 3855
Glu Val Gly Cys Asp Ala Ile Asp Glu Leu Val Ile Glu Thr Pro
3860 3865 3870
Leu Val Val Pro Val Thr Gly Ala Val Asp Leu Thr Val Thr Val
3875 3880 3885
Asp Arg Ala Asp Asp Ala Thr Gly His Arg Pro Val Thr Val His
3890 3895 3900
Ala Arg Pro Glu Gly Ser Asp Ala Trp Thr Arg His Ala Thr Gly
3905 3910 3915
Thr Leu Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Thr Ala Thr
3920 3925 3930
Ala Pro His Thr Pro Asp Thr Pro Asp Leu Phe Leu Gln Trp Pro
3935 3940 3945
Pro Ala Asn Ala His Pro Val Asp Leu Thr Ala Phe Tyr Asp Glu
3950 3955 3960
Leu Ala Ala Ala Gly Tyr Gly Tyr Gly Ser Ala Phe Gln Gly Leu
3965 3970 3975
Arg Ala Ala Trp Arg Ala Gly Asp Thr Thr Tyr Ala Glu Val Thr
3980 3985 3990
Leu Ser Asp Glu Pro Ala Ala Glu Ala Pro Arg Tyr Gly Val His
3995 4000 4005
Pro Ala Leu Leu Asp Ala Ala Leu Gln Ala Val Ser Leu Thr Val
4010 4015 4020
Pro Asp Gly Ser Ala Thr Cys Cys Gly Leu Pro Phe Ala Trp Thr
4025 4030 4035
Gly Val Arg Leu Val Thr Val Gly Pro Ala Thr Leu Arg Val Met
4040 4045 4050
Leu Thr Arg Asp Gly Asp Thr Leu Ser Leu Arg Ala Ala Asp Ser
4055 4060 4065
Thr Gly Arg Leu Val Ala Glu Ile Arg Thr Ile Arg Thr Arg Pro
4070 4075 4080
Leu Ser Pro Pro Met Gly Ala Gly Leu Leu Arg Leu Ala Trp Thr
4085 4090 4095
Glu Val Pro Val Pro Val Asp Ile Pro Thr Gly Asp Val Asp Val
4100 4105 4110
Ile Thr Leu Leu Thr Gly Thr Asp Asp Asp Pro Thr Ala Lys Thr
4115 4120 4125
Arg Thr Leu Thr Ala His Leu Leu Glu Ala Leu Thr Ser Ala Asp
4130 4135 4140
Lys Pro Leu Leu Val His Thr Thr Arg Pro His Thr Thr Gly Gly
4145 4150 4155
Leu Ala Thr Thr Asp Pro Leu Ala Thr Ala Ala Ala Ala Gly Leu
4160 4165 4170
Leu Arg Ala Ala Gln Ala Glu Gln Pro Gly Arg Phe Val His Val
4175 4180 4185
Glu Thr Glu Pro Gly Val Thr Leu Asp Arg Glu Gln Arg Arg Ile
4190 4195 4200
Ala Phe Ala Leu Gly Glu Pro Arg Leu Arg Leu Arg Arg Gly Arg
4205 4210 4215
Phe Glu Ala Ala Arg Leu Thr Arg Val Pro Glu Pro Leu Ile Val
4220 4225 4230
Pro Gln Ser Asp Thr Trp Leu Val Arg Pro Ser Gln Thr Gly Thr
4235 4240 4245
Leu Asp Gly Leu Thr Ala Val Asp Ser Ala Glu Pro Trp Arg Pro
4250 4255 4260
Leu Ala Pro Thr Glu Val Arg Val Gly Val Arg Ala Ala Gly Leu
4265 4270 4275
Asn Phe Arg Asp Val Leu Ile Ala Leu Gly Thr Tyr Pro Gly Lys
4280 4285 4290
Gly Val Leu Gly Gly Glu Ala Ala Gly Val Val Leu Glu Ile Gly
4295 4300 4305
Ser Gly Val His Asp Leu Ala Pro Gly Asp Arg Val Phe Gly Leu
4310 4315 4320
Val Gly Thr Gly Phe Gly Pro Thr Val Ile Ala Asp Trp Arg Met
4325 4330 4335
Leu Gly Arg Met Pro Asp Gly Trp Thr Tyr Pro Gln Ala Ala Ser
4340 4345 4350
Val Val Thr Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp Leu
4355 4360 4365
Ala Lys Leu Arg Pro Gly Glu Lys Ile Leu Ile His Ala Ala Ala
4370 4375 4380
Thr Gly Val Gly Ala Ala Ala Val Gln Ile Ala Arg His Leu Gly
4385 4390 4395
Ala Asp Ile Tyr Ala Thr Ala Gly Ala Pro Lys Gln His Leu Val
4400 4405 4410
Asp Leu Asp Asp Ala Thr His Leu Ala Asp Ser Arg Thr Pro Glu
4415 4420 4425
Met Thr Ala Thr Phe Pro Pro Val Asp Val Val Leu Asn Ser Leu
4430 4435 4440
Thr Gly Asp Leu Leu Asp Ala Ser Val Ala Leu Leu Ala Thr Gly
4445 4450 4455
Gly Arg Phe Ile Glu Leu Gly Lys Thr Asp Leu Arg His Thr Val
4460 4465 4470
Gln Gln Pro Phe Asp Leu Met Asp Ala Gly Pro Asp Arg Leu Gln
4475 4480 4485
Gln Ile Ile Thr Glu Leu Leu Gly Leu Phe Ala Asp Asn Thr Leu
4490 4495 4500
His Pro Leu Pro Val Thr Val His Asp Met Arg Gln Ala Arg Asp
4505 4510 4515
Ala Leu Ala Val Met Ser Arg Gly Ala His Val Gly Lys Ser Val
4520 4525 4530
Leu Thr Val Pro Arg Pro Leu Asp Pro Glu Gly Ala Val Leu Ile
4535 4540 4545
Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Leu Ala Arg His Leu
4550 4555 4560
Asp His Pro His Thr Tyr Leu Leu Ser Arg Thr Pro Pro Pro Asp
4565 4570 4575
Thr Thr Pro Gly Thr His Ile Pro Cys Asp Val Ser Asp Pro Thr
4580 4585 4590
Gln Leu Thr Thr Ala Leu His His Ile Pro Gln Pro Leu Thr Gly
4595 4600 4605
Ile Phe His Thr Ala Gly Thr Leu Asp Asp Ala Leu Leu Asp His
4610 4615 4620
Leu Thr Pro His Arg Ile Asp Thr Val Leu Lys Pro Lys Ala Asp
4625 4630 4635
Ala Ala Trp His Leu His His Leu Thr Gln His Thr Asp Leu Ala
4640 4645 4650
Ala Phe Val Leu Tyr Ser Ser Ala Ala Gly Val Leu Gly Thr Pro
4655 4660 4665
Gly Gln Gly Asn Tyr Val Ala Ala Asn Ala Phe Leu Asp Ala Leu
4670 4675 4680
Ala Glu His Arg Arg Thr Gln Gly Leu Pro Gly Leu Ser Ile Ala
4685 4690 4695
Trp Gly Leu Trp Asp Glu Ala Ser Gly Leu Thr Gly Glu Leu Thr
4700 4705 4710
Asp Ala Asp Arg Arg Arg Met Arg Glu Gly Gly Ala Arg Ala Leu
4715 4720 4725
Thr Ala Glu Gln Gly Met Arg Val Tyr Asp Ala Ala Val His Ala
4730 4735 4740
Gly Thr Gly Ser Val Val Ala Val Ala Gly Glu Leu Pro Ala Gly
4745 4750 4755
Leu Pro Leu Leu Arg Gly Arg Ala Lys Gln Val Val Arg Arg Ser
4760 4765 4770
Ser Arg Asp Glu Val Gly Pro His Thr Asp Leu Leu Thr Leu Val
4775 4780 4785
Arg Gln Lys Ala Ala Val Leu Leu Gly His Ser Gly Pro Asp Asp
4790 4795 4800
Ile Pro Glu Asp Ala Ala Phe Arg Glu Leu Gly Val Asp Ser Leu
4805 4810 4815
Ile Ala Val Gln Leu Arg Asn Gly Leu Asn Glu Ala Thr Gly Leu
4820 4825 4830
Arg Leu Ser Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Arg Ala
4835 4840 4845
Leu Ala Gly Arg Ile Gly Gln Leu Leu Ser Pro Asp Asp Pro Ala
4850 4855 4860
Ala Val Val Ser Thr Gln Leu Asp Arg Leu Glu Ala Leu Leu Ala
4865 4870 4875
Gly Ile Asp Pro Gly Asp Arg Gly Thr Asp Ser Ile Gly Thr Arg
4880 4885 4890
Leu Gly Ala Leu Leu Asp Arg Trp Gln Arg Ala Gly Arg Pro Ala
4895 4900 4905
Glu Pro Ala Gly Val Leu Ser Glu Glu Ala Thr Ala Asp Glu Ile
4910 4915 4920
Phe Asp Leu Ile Asp Arg Glu Leu Arg
4925 4930
<210> 117
<211> 14787
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 117
atggcgcgtg cggaatcgat ccggcctctg cacgaactgc tccgcgtgaa ttccgaacgg 60
cgcggcgacc gggtcgccta cacggattcc cgacgcgccg tgacgtacgc gcagctccac 120
atccgctccg gccggatagc cggacacctc accgcgtccg gcgtgggccg cggcgaccgc 180
gtcgcgctgc tgctcggcaa ccggatcgag acgatcgagg cctatctcgc cgccgcgcgc 240
gccgccgccg tcgcggtgcc gctcaacccc gacgccggcg acgccgagct ggcccacttc 300
ctgtcggact ccggcgcgac cgtgctggtc accgacgacc tccacctcga ccaggtacgg 360
cgcgtcggca cccgcgccac cgtcgtgctg gccggtcggc gggaacaggg ctgtatcgcg 420
tacgaggacc tggccggaac cgaaccgccg tgcccgccct gcgacgacct cggcctggac 480
gaacccgcct ggatgctcta cacgtccggg accacggggc gcccgaaggg cgtcgtctcc 540
gcgcagcgca gcggcctgtg gtccgcgaag tactgtgacg tgccgtcctg gcagctcacc 600
gaggacgacg aactgctgtg gccggcgccg ctgttccaca gtctcggcca ccacctctgc 660
ctgctcgcgg tcctcaccgt cggcgcgtcg gcccgcatcc tcggcggctt cgtcgcgcgt 720
gacgtactcg acgccctggc cgaacacccg tgcaccgtgc ttgtcggcgt gccgacgatg 780
taccgctacc tcctcggagc cgtctccggt gaggccggcg gcgtctcggg cgggaccggg 840
accggggccg tctccggtgg gacgggggcc gtctccggtg gggcggagac ccgcgcgttg 900
cgcgtggcac tggtcgcggg ctccacctcg ccggcgtcgc tcacggcggg gttcgaagcc 960
gcgttcggcg tgccgctgct cgacacctac ggctgcacag agacgaccgg ctcactcacc 1020
gccaacaccc tgaccgacgc gcgggtcccc ggctcgtgcg ggctgccggt gcccggcctg 1080
tcgctccgct tcgtcgatcc ggtgtcaggc gccgacgtgg cgcgcggcga cgagggcgag 1140
ctgtgggcga gcgggccgag cctcatgctc ggataccacg cgcaggccga ggcgaccgcc 1200
caggtgctgg tggacggctg gtaccgcacc ggagatttgg cacgccaggc ggagaccggg 1260
catgtgacga tcacgggccg cgtcaaggaa ctcatcatcc gcggcgggga gaacatccac 1320
ccacgggaga tcgagtccgt ggcccaggag gtgccaggag tcagggacgc cgccgccgcg 1380
ggacgcccgc accccgtcct cggcgagata cccgtgctct acgtcgtgcc ggaaggtccc 1440
agggtcccgg ccgaggcgat cctcgcggag tgccgcagcc aactctccta cttcaaggtg 1500
cccgacgaaa tcctgcacgt caccacggtc ccgcgcaccg cgtcaggcaa ggtgcgccga 1560
ggggagctcg cggcgctgcc tgcccgcctc gtcgccaccg gcagcggcga ggcgacactg 1620
tgcgaggtga tctgggagcg gcgcgacctg cccgacacgg tgccggagct gcgcgacctg 1680
cccggcaccg tttcccaggg ccggacggtg gtcacccgcc gcgcgatcgg ggtcggcccg 1740
gccgaggtgc cggacgcgga ccaggcagcg ctgtgggacg aagcgctcag gcgacaggcg 1800
gccgagcccg gttcgttcgt actggtggac acggacggcg acggcagcga cggtcacgat 1860
ggcgatggcg atggcggtgg cggtggcggt ggcgatggcg gtggcgatgg cgatggcggc 1920
gcggagcgcg tcgccgccgc ggcgtcgctc ggggaacccc aggtcgcgct acgggccggg 1980
gtggcctacg tgccccgact ggtaccagcg gacaccaccc ccctgccgac cgcgcggtgg 2040
gcgctgcgcc caccggcatc cggcgcgctc cgcgacctgg ccgtcgcccc gctgggcacc 2100
gcgtctgacg ccgcgccgcg ccccctggcc gtcggcgagg tccgcgtgga tgtccacgcc 2160
gcggggctga acttccgcga cgtactgatc gcgctcggca cctacccggg cgacggcgag 2220
atgggtgggg aggccgcggg gatcgtgacc gaggtcgggc ccggcgtcga agacctggcg 2280
ccaggcgacc gcgtgttcgg tctcgtgcgg gacgcgttcc gtcgcagcgt cgtagcggac 2340
cggaggctgg tcgcgcgagc gccgcgcggc tggtcgttcc cggtcgccgc ctccgtgccc 2400
atcgtgttcg cgacggcgtg gtacggcctt gtcgacgcgg gcgccgtgcg gccgggccag 2460
aaggttctga tccacgcggc gacgggcggc gtgggtatgg ccgccacccg gatcgcccgc 2520
catctcggcg ccgaggtgta cgccaccgcg agccccgcca aacagcacct gctgtacgcc 2580
gacggcttcg acaccgacca cgtggcgaac tcccgcacca ccgggttcgc cgacgtgttc 2640
cccccggtcg acgtcgtact caactccctc accggtgacc tgctcgatgc ctccgtcgcc 2700
ctgctcgcgc ccggcggccg gttcgtcgaa atgggaaaga ccgacatccg ccacgacgtt 2760
cagcagccct tcgacctgtc cgacgtcgac cccgcgcggc tgcgggacat cctagatctg 2820
ctcctcggac tcttcgacgg cgacgagctg cgcccgctgc cggtacggcc gtgggacatc 2880
cgccgcgcgc gggacgcgtt cgcgtggatg agccaggcca ggcacaccgg caagatggtc 2940
ctcaccgtgc cgcagccgct cggcccgcgg tcgtcgatcc tggtcacggg cgatggcgcc 3000
gacgccgtcg ccgacctgct ccgcgaggag acgggcctcg gacacgtcgc caccggggtc 3060
gcggaagccg cgggggccgc gggggctgag ggagccgggg gagtggcggg agccaccgaa 3120
gacgctgagg ccacagcggt cacgggggag cccgagaccg aggagcgcgg gaacgcgagc 3180
gcactcgtac atgtgctgct cggcgatccg gccgctgccg acgcgtatgc caggtcccga 3240
gcctcggagg ggctcccgat cgtcacggtc catgggctgc ccggcatcga acaggcagct 3300
ctgaccagcg agttgctgga aaaggccatc gagggcggcg gctcgtacgt cgtcacccgg 3360
cccgattcct ccggggcacg ggccgaggcg atggcgggcg cgacaccgcc gatcctgacc 3420
cggctcaccg gcccggccgg cctcaccgga ccggctggac cggcagggcc ggcgggtcag 3480
gtcaggcccg gcgccggggg accggagtgg gcgagccgcc tcgcggcggc cgacgccgac 3540
cgggagacgg tgatgctcgg cctggtccgc gacagccttg ccaccgtcct cggtctgccg 3600
ggcgccgaac actgcgcgcc ggaccgtacg ttccgtgaga acggtctcga ctcgctcacc 3660
accgtcgaat tcgcgaacat cgtggcctcg cggatcggcg cgcgcgttcc ggcgtccacc 3720
gcgttcgacc atcccacgcc gcgttcgttc gccgcgcacc tcgcaggctc cgcggcggcg 3780
gcgcccgcag cccgcgccac cgtcgactca ggagaaccgg tcgcgatcgt cggcatggcc 3840
tgccggttgc cggacggcgt ctcctcgccg gaggaactgt ggcacctcgt ggcctccggc 3900
acggacgcga tcaccgagtt ccccggcgac cgaggctggg acgtcgacgc gctggtcgac 3960
ccggacccgg acaaggcagg ccggtccacc acccgccacg gtgggttcct cgccgaggca 4020
gccgggttcg acgccgcgtt cttcgggatc agcccgaacg aggcactggc catggatccg 4080
cagcagcggc tggtactgga gacttcttgg gaagccttcg agtgcgcggg gatcgtgccg 4140
gacacgctca gggagagcga caccggcgtg ttcatgggcg cgttccatca ggggtacggc 4200
accggccgcg atctgggcgg tctcggcgtc acggcgaccc agacgagcgt cctgtcgggg 4260
cgcctctcgt acttctacgg gctccagggc ccggccgtca cggtcgacac ggcgtgctcg 4320
tcgtcgctgg tcgccctgca ccaggcagcg caggcgctgc gctcggggga gtgctcgctc 4380
gcgctggccg gtggcgtcac ggtgatggcg acgccgcaga gctttgtgga gttctccagg 4440
cagcgggggc tcgccccgga cggccggtgc aaggcgttcg ccgactcggc ggacggcaca 4500
gggttcgcag aaggcgtcgg tgtcctcgtc ctggaacggc tatccgacgc ggaacgcaac 4560
ggccacaccg tcctcgcggt cgtacgtggc tcggccgtga accaggacgg cgcgtccaac 4620
ggtctctccg cgcccaacgg tgtcgcacag cagcgcgtga tcaggcaggc cctggcgaac 4680
gccggactga gcggcggcga cgtggatgtg gtggaggcgc atgggacggg gacggtcctg 4740
ggtgatccga tcgaggcgca ggcggttttg gcgacgtacg ggcagggtcg tgaagtcccg 4800
ctgctgctcg gctcggtcaa gtcgaacgtc ggccataccc aggcggcggc gggtgtggct 4860
ggtgtgatca agatggtgat ggcgatgcgg tacggggtgg tgccgcggac gttgcatgtg 4920
gatgagccgt cgtcgcatgt ggactggtcg gcgggggcgg ttgagctgtt gacggaggcg 4980
aggccgtggc cggggtcggg gcgttcgcgc cgggcggggg tgtcgtcgtt cggggtgagc 5040
ggcaccaatg cgcatgtgat tttggagggg gtgcctgagc tgcctccggg tgggcggacc 5100
tcgccggatg aaggtgcggt gtcggggttg gtgccgttgc cggtgtcggc tcgtacggaa 5160
tcgagtctgg cgtcgctggt ggagcggctg gatgtgtatg tgcggggcgg gtcgtccgtg 5220
ggtgggggcc tcggtggggt ggcggatggt ctggtgcggg ggcgtgcggt gttcggtcat 5280
cgtgcggtac tgctcgggga gagccgtgtc accggggtgg cggtggacgg gttgcggacg 5340
gtgttcgtgt ttccggggca gggttcgcag tgggtgggta tgggtgtggc gttgatgtcc 5400
gcctcggagg tgttcgcggc ccggatggcc gagtgtgcgg cggctttgga gccgttcacg 5460
ggctgggatg tgcgggacat gctgtccggg cccgaagtgt tggagcgggt ggaggtgttg 5520
cagccggcgt cgtgggcggt ggcggtgagt ctggccgcgc tgtggcgggc gcacggggtg 5580
gtgccggatg cggtggtggg gcattcgcag ggggagatcg ccgccgcgtg cgtggcgggg 5640
gccctcaccc tggaggacgg ggcacggatc gtggcccgcc gcagccggag catcgccgcc 5700
cgtctcgccg gtcacggcgc gatggcgtcc atcgccgtgc ccgccgccga ggtggagacg 5760
gtggaggggg tgtggatcgc ggcccgtaac gggcccgcct ccaccgtgat cgcgggggat 5820
ccggaggcgg tggagcaggt tctggcccgg tacgagcatg acggggtgcg ggtgcggcgg 5880
atcgcggtgg actatgcctc gcacactccg cacgtggagg cgatcgagga cgaactcgcc 5940
gaggccctgg agggggtgag cgcccaggcc ccgacgatcc cgtggtggtc gaccctcgac 6000
agcggctgga tcagtgaacc cgtcgaggac ggttactggt atcgcaatct gcgtcggccg 6060
gtggcgatgg acaccgccgt cagggaactg gacggttccc tgtttctcga atgcagtgcc 6120
cacccggtcc tgctgcccgc cctcgaccag ccgcacaccg tcgcgtccct gcgtaccggg 6180
gacggcggcc atccccgctt cgtcaccgcc ctggccgagg cctggaccca gggcgcaccc 6240
gtcgactgga ccaccctcat cgcccccgtc acccccacgg cccggctgct ggacctgccc 6300
acctacccct tcgaccacaa gcgttactgg atcgaggcca ccaccacccc cggcctcacc 6360
gacaccgccc accccatgct ggccgccacc accgcactgc ccaccaccga cggcaccgtc 6420
ctcaccggcc gcatctccct acgcacccac ccctggctcg ccgaccacac catccaggac 6480
accgtcctgc tccccggcac cgccttcctc gaactcgccg tacgcgccgg agacgaaacc 6540
ggctgcgaca ccatcgacga actcgtcatc gaaacccccc tcaccctccc cgccaccacc 6600
gccgtcgacc tcaccctcac catcgaccca cccgacacca caggacacca ccccctcacc 6660
atccacgcac gccccgaagg aacccacacc tggacccgcc acgccaccgg caccctcagc 6720
cgtgccggaa acggagacgg agacatcgca gcgggctacc cgtccgcgtg gccgccgccg 6780
gaggcgcaac ctgtcgatgt caccgggttc tacgagcggc tcgccgagat cggctacatc 6840
tacggcccgg cattccgcgg cctgcgcgcc gcttggcgca gcggcgaaac cctgtacgcc 6900
gaggtggaga tcaccgggga agaggcggaa cagacggaac aggcgggcga cgcgtccagc 6960
tacggcgtac acccggccct gctcgatgcg gcgctgcacg tcacctgcct gccgctgctc 7020
accgggcggg gatcggagca ggagccggag tccaggtcgg agtcggaacc ggagtctgcc 7080
tccgagccgg aggtgaagct gccgttctcg tggagcggtg tccggttcca cacgaccggc 7140
gccaccacgt tgcgtgtggc gatcacccag ggcccgaatg gcgtggccgt gcacgcggcg 7200
gacccggcag gccaccctgt ggtgacggtc tccgagttgg ccgcgcgacc ggtgaacgtc 7260
cgcaccgacg cctacaccga cgccaccgtc cgcgactccc tgtaccacct ctcctggacc 7320
gagctgccca ctccggcagc cgccacagtc ggtcctggcc ccacagccga cccagccccc 7380
acagtcgacc cagccccctc agcgggtcct ggctccacag ccggtcccgg ccacgcggat 7440
gaggtccaag tcgtctcagc gatcccggag ccggacgcgg acgtgctcga cgagacgtac 7500
cggctcaccg cgctcgtact cggtgagctg caccgggtgg tcgccgacga cagcctcgcg 7560
gcgaccactc tcgtcgtccg tatcgacgcg gggccgaccg ggggagcggt cgccggcctt 7620
gtcaggtccg cgcaggccga acaccccggc cggttcgtcc tcgtggagac cggcggcgac 7680
acccccttcg agacactggc cgcggccacg acactggcgg aaccgtacgt tcgcgtcacc 7740
gacggccggt acgaggcccc ccggctccgc cggacggccg ccacacggac gcacgagccg 7800
ttgctcgacc cggaaggcac ggtggtcatc actggaggct cgggtgtgct ggccggtctc 7860
ctcgctcggc gcctggtcgc cgagcacggc gcccgccacc tgttgctgct ttcgcgcagc 7920
gaaccgccgg tggacacgcc cggtgtccac atccgctgcg acgtctccga caaggaccaa 7980
ctcgccgccg cgctcgccgc agcggaccgg cccctcacgg cggtcttcca cacggcagcg 8040
gtgctcgacg acggcgtgat cgcggcactc acgccggagc ggctcgccac cacgctgcgg 8100
cccaaggcag acggagcctg gcatctgcac gaactgaccc gaggcgcgga cctgcgcgcg 8160
ttcgtcctct actcgtcggt cgcgggcatc ctgggcggtc gcggccaggc caactactcg 8220
gcggcgaacg ggttcctcga cggtctcgcc gcgtcgcgcc gcgccgaggg gctgcccgca 8280
ctgtcactgg cctggggtct gtgggccgac gacagcggac tcaccggcac tatgagcggc 8340
acgaacagga cccgcgtacg gcgcggcggt ttccgcccca tgcgagcagg actggccctc 8400
cgcctgttgg aaaccgccgc aggtaccggc gccgcgttcg ccgtggcggc cacgatggat 8460
ccgaacgcgc aggcgtcccc tctcttcatg gggctgcgcc gttccgtgcc gcgaagggcg 8520
gccgccacga ctgttccgct cgccgagcgg ctcggcgcca tgaccggtgc cgaccgggat 8580
gccgcgctgc tcgcgctcgt ccgcgactgc gcggcggcgg tactcggcca cgtggacgcg 8640
acggccgtgc cggcggacgc ggcgttcaag gacctcggtg tcgactcgct gaccgctgtc 8700
gaactgcgga accggctcgc cacggccacc ggtgtccggc tgcccgccac gctggccttc 8760
gaccatccaa caccacgggc catcgcgtcg cggctggacg agacgatggc ggggagcacc 8820
gttccggcag ccgtcccggc agcggcctcg gtaaccgccg cgacccgcga cgatccgctc 8880
gcgatcgtcg gcatggcgtg ccgcctgcca ggcggagtcg cctcgccgga cgacctgtgg 8940
cggatgctgg acaacggtgg cgacgcggtc accggcttcc cggccgaccg tggctgggac 9000
ccgtcaggcc tcaccggcgg accggacgcg gaccgtggcg gcttcctctc cgacgccgcc 9060
gacttcgacg ccgccttctt cgggatcagc ccccgcgagg cgctggcgat ggacccgcaa 9120
cagcggatca tgctggagac gacctgggag gcgttcgaga gcgcgggcat cgtgccggcc 9180
acgctccgcg ggagcgacac cggcgtgttc attggggctt tctcgtacgg gtacggcgtc 9240
ggcgccgaca tgggcgggtt cggctcgatc ggcgtgcagc ccagcgtcct caccggccgg 9300
atctcgtact tctacggtct gcaaggaccg gccttcaccg tcgacacggc gtgctcgtcg 9360
tcgctggtcg cactgcacca ggcggggtac gccctgcgcc acggcgagtg ctcactcgcc 9420
ctggtcggcg gcgtcacggt gatggcgacc ccaaccggat tcgtcgaatt ccagcagcag 9480
ggcgggctct ctccggacgg ccgctgccgc gcgttcgccg acacagcgaa cggcacgggt 9540
tgggcggagg gtgcgggtgt tctcgtcgtg gaacggctct ccgacgcgga gcgtaagggg 9600
cacagggttc tcgcggtggt gcgtggttcg gcggtgaatc aggatggtgc gtcgaatggt 9660
ctgtcggcgc cgaatggtcc ggcgcagcag cgggtgattc ggcaggccct ggcgaacgcc 9720
ggactgagcg gcggcgacgt ggatgtggtg gaggcgcatg ggacggggac ggtcctgggt 9780
gatccgatcg aggcgcaggc ggttttggcg acgtacgggc aggggcgtga ggtcccgttg 9840
ttgttgggtt cgttgaagtc gaatattggt catgcgcagg ctgcggcggg tgtggctggt 9900
gtgatcaaga tggtgatggc gatgcggtac ggggtggtgc cgcggacgtt gcatgtggat 9960
gagccgtcgt cgcatgtgga ctggtcggtg ggggcggttg agctgttgac ggaggcgagg 10020
ccgtggccgg ggtcggggcg ttcgcgccgg gcgggggtgt cgtcgttcgg ggtgagcggc 10080
accaatgcgc atgtgatttt ggagggggtg cctgagctgc ctccgggtgg gcggaccgcg 10140
ccggatgagg gtgcggtgtc ggggttggtg ccgttgccgg tgtctgctcg tacggaatcg 10200
agtctggcgt cgctggtgga gcggctggat gtgtatgtgc ggggcgggtt gtccgtgggt 10260
gggggcctcg gtggggtggc ggatggtctg gtgcgggggc gtgcggtgtt cggtcatcgt 10320
gcggtgctgc tgggggagag tcgtgtcgcc ggggtggcgg tggacgggtt gcggacggtg 10380
ttcgtgtttc cggggcaggg ttcgcagtgg gtgggtatgg gtgtggcgtt gatggccgcc 10440
tcggaggtgt tcgcggcccg gatggccgag tgtgcggcgg ctttggagcc gttctcgggc 10500
tgggatgtgc gggacatgct gtccgggccc gaagtgttgg agcgggtgga ggtgttgcag 10560
ccggcgtcgt gggcggtggc ggtgagcctg gccgcgctgt ggcgggcgca cggggtggtg 10620
ccggatgcgg tggtggggca ttcgcaggga gagatcgccg ccgcctgcgt ggccggggcc 10680
ctcaccctgg aggacggggc acggatcgtg gcccgccgca gccggaccat cgccgcccgt 10740
ctcgccggtc acggcgcgat ggcgtccatc gccctcagcg cctcggaggt ggagacggtg 10800
gagggggtgt ggatcgcggc ccgtaacggg cccgcctcca ccgtgatcgc gggggatccg 10860
gaggcggtgg agcaggttct ggcccggtac gagcatgacg gggtgcgggt gcggcggatc 10920
gcggtggact atgcctcgca cactccgcac gtggaggcga tcgaggacga actcgccgag 10980
gccctggagg ggatcaccag tcgggccccg acaatcccgt ggtggtcgac cctcgacagc 11040
ggctggatca gtgaacccgt cgaggacggt tactggtatc gcaatctgcg ctggccggtg 11100
gcgatggaca ccgccgtcag ggaactggac ggttccctgt tcctcgaatg cagcgcccac 11160
ccggtcctgc tgcccgccct cgaccagccg cacaccgtcg cgtccctgcg taccggggac 11220
ggcggccatc cccgcttcgt caccgccctg gccgaggcct ggacccaggg cgcacccgtc 11280
gactggacca ccctcatcgc ccccgtcacc cccacggccc ggctgttgga cctgcccacc 11340
taccccttcg accacaagcg tttctggctg cgtcccgtcc tgccgggggg tgaggggatc 11400
ggtcatccgc tgttgtcgag tgcggtggtg ttgccgggca gtgatggggt cgtgctgacg 11460
ggtcggctgt cgttggcgac tcattcctgg ctggccgatc acagggtgtg ggacacggtg 11520
ctgttgccgg gtacggcctt tctggaactc gtggtgcggg cgggtgatga ggtcggttgc 11580
gacgcgatcg acgagttggt catcgagacc ccgctcgtgg tgccggtgac cggtgccgtg 11640
gatctcactg tcaccgtcga ccgggccgat gatgccaccg gtcaccgccc ggtgaccgtc 11700
cacgcacggc ccgaaggttc cgacgcctgg acccgccacg ccaccggcac cctcaccacc 11760
acaaccacaa ccacaaccac aaccacagcc accgcccccc acaccccaga cactcccgac 11820
ctgttccttc agtggccccc cgccaacgcg caccccgtcg acctcaccgc tttctacgac 11880
gaactcgccg ccgccggtta cggctacggc tccgcgttcc agggactgcg cgccgcatgg 11940
cgggcgggtg acacgaccta cgcggaagtc accctctccg acgagccggc cgccgaggcg 12000
ccccgctatg gcgtgcaccc cgccctgctc gacgcggccc tgcaagccgt gtccctcacc 12060
gtgccggacg gtagctcccc cggcctgccg ttcgcgtgga ccggggtccg gttggtcacc 12120
gtgggcccgg caacgctccg cgtcatgctc acccgggacg gggacacgct gagcctgcgt 12180
gccgccgact ccaccggccg gctggtcgcc gagatccgga cgatccggac ccgcccgctg 12240
tccccgccca tgggcgccgg cctgctgcgt ctggcctgga ccgaggtccc cgtacccgtg 12300
gacataccca cgggcgacgt ggacgtcatc accctgctca ccggcaccga cgacgacccg 12360
acggccaaga cgcgtacgct gacagcccac ttgcttgagg ccctgaccag cgccgacaag 12420
cccctgctcg tgcatacgac acgcccgcac accaccgggg gcctcgccac caccgatccc 12480
ctcgccaccg ccgcggctgc cgggctcctt cgcgccgccc aggccgagca gcccggccgg 12540
ttcgtccacg tcgagaccga gcccggcgtc accctcgacc gcgagcagcg gcgaatcgcc 12600
ttcgcactgg gcgagccacg cctccgcctg cgccgagggc gtttcgaggc ggcccgtctc 12660
actcgcgtgc cggagccgct catcgtgccg cagagtgaca cgtggctggt ccgaccgtca 12720
cagacgggca cgctcgacgg cctcaccgcg gtcgattcgg cggagccgtg gcgccccttg 12780
gccccgaccg aggtccgggt cggtgtacgt gcggcgggtc tcaacttccg tgatgtgctg 12840
atcgcgctcg gcacctaccc cggtaagggc gtactcggcg gcgaggcggc gggcgtcgtc 12900
ctggagatcg gatccggcgt gcacgacctg gcgcccggcg accgcgtctt cggcctcgtg 12960
gggaccggct tcggccccac ggtcatcgcc gactggcgga tgctgggccg gatgcccgac 13020
gggtggacgt atccgcaggc ggcgtcggtg gtgaccgtgt tcgcgaccgc ctggtacggc 13080
ctggtggacc tggcgaagct gcgccccggc gagaagatcc tgatccacgc ggcggcgacc 13140
ggggtcggcg cggcggccgt acagatcgcc cgccacctcg gcgccgacat ctacgccacc 13200
gccggcgcac ccaagcagca cctcgtggac ctggacgacg ccacccacct cgccgactcc 13260
cgcacccccg agatgaccgc caccttcccc ccggtcgacg tcgtactcaa ctccctcacc 13320
ggcgatctcc tcgacgcctc cgtcgccctc ctcgccaccg gcggccggtt catcgaactg 13380
ggcaagaccg acctccgcca caccgtccaa caaccctttg acctgatgga cgcgggcccc 13440
gaccggctcc agcagatcat caccgaactc ctcggcctct tcgccgacaa caccctccac 13500
ccgctaccgg tcacggttca cgacatgcgg caggcccgcg acgcgctggc ggtcatgagc 13560
cggggcgctc acgtcggcaa gtcggtgctg acggttcccc ggcccctcga ccccgagggc 13620
gccgtcctca tcaccggcgg ctccggcacc ctcgccggca tcctcgcccg ccacctcgac 13680
cacccccaca cctacctcct ctcccgcacc ccgccaccgg acaccacccc cggcacgcac 13740
atcccctgcg acgtcagcga ccccacccaa ctcaccaccg ccctgcacca cataccccaa 13800
cccctcaccg gcatcttcca caccgccggc accctcgacg acgccctcct cgaccacctc 13860
accccccacc gcatcgacac cgtccttaaa cccaaagccg acgccgcctg gcacctccac 13920
cacctcaccc aacacaccga cctcgccgca ttcgtcctct actcgtccgc ggcaggtgtg 13980
ctgggcacgc cggggcaggg caactatgtg gcggcgaacg ctttcctcga cgcgctcgcg 14040
gaacaccgcc gtacgcaggg gctgccaggg ctgtcgatag cgtgggggct gtgggacgag 14100
gcgagcggtc tgaccggcga gctgaccgac gccgaccggc gccgtatgcg ggagggcggg 14160
gcgagagcgc tcaccgccga gcagggcatg cgcgtgtatg acgccgccgt acacgccgga 14220
acgggtagtg tcgtcgccgt ggcaggtgaa ctccccgcag gattaccgct gttgcgtggc 14280
cgtgccaaac aggtggttcg tcggagctcc cgcgacgagg tcgggcctca cacggacctc 14340
ctcacgctcg tacgacagaa ggcggccgtc ctgctggggc attcgggacc ggacgacatc 14400
ccggaggacg cggcgttccg ggagctcggc gtcgactcgc tcatcgcggt gcaactgcgc 14460
aacggcctca acgaagcgac cggtctgcgg ctctccgcca cgctcgtctt cgactacccc 14520
acgccgcgcg cgctcgccgg ccgtatcggc caactcctgt cccccgacga cccggcggct 14580
gtggtgtcca cgcaactcga ccgccttgag gcactgctcg ccggcatcga ccccggcgac 14640
cgcgggaccg actcgatcgg gacccgtctg ggcgccctcc tcgaccgctg gcagcgtgcg 14700
ggccgccccg ccgaaccggc cggtgtgctg tccgaggagg cgacagcgga cgagatcttc 14760
gacctcatcg accgggagtt gcgatga 14787
<210> 118
<211> 333
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 118
Leu Ser Ala Pro Val Ala Ala Pro Tyr Cys Arg Phe Glu Lys Ile Gly
1 5 10 15
Ser Pro Asp Leu Asp Gly Asp Glu Thr Val Leu Gly Val Ile Glu His
20 25 30
Gly Thr Gly His Thr Gly Ala Ser Leu Val Asp Gly Val Pro Arg Thr
35 40 45
Ala Val His Thr Thr Thr Arg Asp Glu Gln Ala Phe Ala Glu Val Trp
50 55 60
His Ala Pro Gly Pro Val Glu Ser Gly Thr Asp Asp Gly Ile Ala Trp
65 70 75 80
Ala Arg Thr Gly Glu Tyr Leu Phe Gly Val Gly Arg Val His Glu Ser
85 90 95
Gly Arg Tyr Ala Asp Ala Val Ser Ala Leu Tyr Thr Arg Ile Phe Gly
100 105 110
Leu Thr Arg Ser Leu Gly Arg Pro Leu Leu Ala Arg Thr Trp Asn Tyr
115 120 125
Ile Ser Gly Ile Asn Ser Ala Asn Ala Asp Gly Leu Glu Val Tyr Arg
130 135 140
Asp Phe Cys Val Gly Arg Gly Gln Ala Leu Asp Gly Leu Gly Val Asp
145 150 155 160
Pro Ala Gly Met Pro Ala Ala Thr Gly Ile Gly Ala His Gly Gly Gly
165 170 175
Ile Ala Cys Val Phe Ile Ala Ala Arg Gly Gly Val Arg Val Asn Ile
180 185 190
Glu Asn Pro Ala Val Leu Thr Ala His His Tyr Pro Ala Ala Tyr Gly
195 200 205
Pro His Pro Pro Val Phe Ala Arg Ala Thr Trp Leu Gly Pro Gly Glu
210 215 220
Glu Gly Gly Arg Leu Phe Val Ser Ala Thr Ala Gly Ile Leu Gly His
225 230 235 240
Glu Thr Thr His His Gly Asp Val Thr Gly Gln Cys Glu Val Ala Leu
245 250 255
Asp Asn Ile Ala Arg Val Val Gly Ala Glu Asn Leu Arg Arg His Gly
260 265 270
Val Pro Arg Gly His Val Leu Ala Asp Val Asp His Leu Lys Val Tyr
275 280 285
Val Arg Arg Arg Glu Asp Leu Ala Ala Val Arg Arg Val Cys Ala Ala
290 295 300
Arg Leu Ser Ser Thr Ala Thr Val Ala Val Leu His Thr Asp Ile Ala
305 310 315 320
Arg Gly Asp Leu Leu Val Glu Ile Glu Gly Val Val Arg
325 330
<210> 119
<211> 1002
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 119
ttgtctgcgc ctgtcgcggc accgtactgc cgcttcgaga agatcggatc gccggatctc 60
gacggcgacg agacggtgct cggcgtcatc gagcacggca caggacacac cggggcgtcg 120
ctggtggacg gcgtcccgcg gaccgcggtg cacaccacga cccgcgacga gcaggcgttc 180
gccgaggtct ggcacgcacc gggccccgtg gagtccggta cggacgacgg catcgcgtgg 240
gcccgcaccg gcgagtacct gttcggggtc ggccgcgtcc acgagagcgg caggtacgcc 300
gacgccgtat cggcgctcta cacgcggatc ttcgggctga cccgatcgct ggggcgcccg 360
ctgctcgccc ggacgtggaa ctacatcagc ggcatcaact cggccaacgc ggacggcctg 420
gaggtgtaca gggacttctg cgtcggccgt ggccaggcgc tcgacgggct cggggtcgac 480
ccggccggca tgcccgcggc caccggcatc ggcgcgcacg ggggcggtat cgcctgcgtg 540
ttcatcgccg cccgcggcgg ggtcagggtc aacatcgaga accccgcggt cctcacggcc 600
caccactacc cggcggcgta cggcccgcac ccccctgtct tcgcacgggc cacctggctg 660
ggcccggggg aagaaggtgg ccggctgttc gtctcggcga cggccggcat cctcggacac 720
gagacgacgc accacggtga cgtgaccggc cagtgcgaag tcgccctgga caacatcgcc 780
cgggtggtcg gcgcggagaa tctgcgccgc cacggcgtcc cacgaggaca cgtcctcgcc 840
gacgtcgatc acctcaaggt ctacgtgcgc cgtcgcgagg atctcgcggc ggtccgccgg 900
gtctgcgccg cgcgcctgtc gagcacggcg accgtcgcgg ttctgcacac cgacatcgcc 960
cgcggtgacc tgctcgtcga aatcgagggg gtggtgcggt ga 1002
<210> 120
<211> 1592
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 120
Val Lys Asn Arg Glu Lys Lys Asn Gln Glu Ile Val Ala Ala Asp Arg
1 5 10 15
Ala Glu Pro Leu Val Ser Ser Phe Ser Gln Arg Arg Ile Trp Phe Leu
20 25 30
Gln Gln Leu Asp Pro Asp Ser Asn Ala Tyr Asn Leu Pro Leu Val Arg
35 40 45
Arg Leu Arg Gly Pro Leu Asp Ala Ala Leu Leu Glu Arg Ala Leu Thr
50 55 60
Leu Val Val Ala Arg His Glu Ala Leu Arg Thr Val Phe Asp Ala Ser
65 70 75 80
Asp Gly Asp Pro Val Gln Arg Val Leu Pro Ala Pro Thr Arg Ile Leu
85 90 95
Arg His Ala Arg Ala Asp Gly Glu Gln Gly Ala Gly Ser Leu Val Arg
100 105 110
Ala Glu Ile Ala Ala Pro Phe Thr Leu Ser Thr Gly Pro Leu Ile Arg
115 120 125
Ala Leu Leu Ile Arg Ile Gly Asp Asp Asp His Val Leu Ala Val Thr
130 135 140
Val His His Val Ala Gly Asp Gly Trp Ser Phe Gly Leu Leu Gln Leu
145 150 155 160
Glu Leu Ala Ala His Tyr Ala Ala Leu Arg Asp Thr Ala Ala Pro Ala
165 170 175
Val Leu Pro Pro Leu Pro Leu Gln Tyr Ala Asp Phe Ala Ala Trp Glu
180 185 190
Arg Arg Glu Leu Ala Gly Ala Gly Leu Glu Lys Arg Leu Ala Tyr Trp
195 200 205
Arg Glu Arg Leu Lys Gly Ala Pro Pro Val Leu Asp Leu Pro Thr Asp
210 215 220
Arg Pro Arg Pro Pro Val Ala Asp Ala Asp Ala Gly Leu Val Glu Trp
225 230 235 240
Arg Pro Pro Ala Ala Leu Ala Thr Ala Val Leu Gln Leu Gly Arg Gly
245 250 255
Ala Gly Thr Ser Val Phe Met Thr Leu Leu Ser Ala Phe Gln Leu Val
260 265 270
Leu Ala Arg Gln Ala Gly Thr Gln Asp Val Leu Val Gly Thr Pro Val
275 280 285
Ala Asn Arg Thr Arg Thr Ala Phe Glu Gly Leu Ile Gly Met Phe Val
290 295 300
Asn Thr Leu Val Leu Arg Gly Asp Leu Ser Gly Asp Pro Thr Phe Arg
305 310 315 320
Gln Leu Leu Asp Arg Cys Arg Ala Thr Thr Ala Asp Ala Phe Thr His
325 330 335
Ala Asp Leu Pro Phe Glu Asn Leu Ile Glu Val Val Ala Pro Asp Arg
340 345 350
Asp Leu Ser Val Asn Pro Val Val Gln Val Leu Leu Gln Val Leu Arg
355 360 365
Arg Asp Ala Thr Thr Ala Ala Leu Pro Gly Val Thr Ser Glu Pro Phe
370 375 380
Gly Thr Gly Arg Trp Phe Thr Arg Phe Asp Leu Glu Phe His Val Tyr
385 390 395 400
Glu Glu Ser Asp Gly Val Leu Thr Gly Glu Leu Leu Tyr Ser Arg Ala
405 410 415
Leu Phe Asp Ala Ser Arg Ile Thr Arg Leu Leu Asp Glu Phe Thr Ala
420 425 430
Val Leu Gly Ala Ala Thr Ala Asp Pro Gly Thr Arg Leu Ser Gln Leu
435 440 445
Pro Val Gly Gly Ala Ala Thr Ser Ala Arg Leu Pro Ser Asn Asp Thr
450 455 460
Ala Arg Glu Leu Pro Val Glu Thr Leu Pro Glu Leu Leu Ala Arg Tyr
465 470 475 480
Ala Ala Arg Thr Pro Asp Ala Val Ala Val Thr Asp Pro Arg Thr Ser
485 490 495
Leu Thr Tyr Thr Glu Leu Asp Arg Arg Ala Asn Arg Leu Ala His Leu
500 505 510
Leu Arg Ala Arg Gly Thr Ala Thr Gly Asp Leu Val Gly Ile Cys Ala
515 520 525
Asp Arg Gly Val Asp Leu Ile Val Gly Ile Val Gly Ile Leu Lys Ala
530 535 540
Gly Ala Ala Tyr Val Pro Leu Asp Pro Glu His Pro Gln Glu Arg Thr
545 550 555 560
Ala Phe Val Leu Asp Asp Ala Arg Leu Thr Thr Val Val Thr His Glu
565 570 575
Ala Tyr Arg Ala Arg Phe Ser Ala Gly Pro Arg Gly Leu Ser Ala Val
580 585 590
Pro Gln Gly Thr Ser Ala Val Pro Gln Glu Ser Ser Ala Val Ser Gln
595 600 605
Glu Ser Ser Ala Val Ser Gln Gly Ala Phe Pro Val Pro His Val Val
610 615 620
Thr Leu Asp Ala Pro Asp Leu Asp Arg Arg Pro Asp Thr Pro Pro His
625 630 635 640
Ile Thr Leu Asp Arg Asp Ser Leu Ala Tyr Ala Ile Tyr Thr Ser Gly
645 650 655
Ser Thr Gly Arg Pro Lys Ala Val Leu Met Pro Gly Val Ser Ala Val
660 665 670
Asn Leu Leu Leu Trp Gln Glu Arg Thr Met Gly Arg Glu Ala Asp Ser
675 680 685
Arg Thr Val Gln Phe Val Thr Ala Thr Phe Asp Tyr Ser Val Gln Glu
690 695 700
Ile Phe Ser Ala Leu Leu Gly Gly Thr Leu Val Ile Pro Pro Asp Glu
705 710 715 720
Ala Arg Phe Asp Pro Pro Gly Leu Ala Arg Trp Met Asp Glu Gln Arg
725 730 735
Ile Thr Arg Ile Tyr Ala Pro Thr Ala Val Leu Arg Ala Leu Val Glu
740 745 750
His Val Asp Pro Asp Ser Asp Gln Leu Ser Ala Leu Arg His Leu Cys
755 760 765
Gln Gly Gly Glu Ala Leu Ile Leu Asp Ala Arg Leu Arg Glu Leu Cys
770 775 780
Arg His Arg Pro His Leu Arg Val His Asn His Tyr Gly Pro Ala Glu
785 790 795 800
Ser Gln Leu Val Thr Gly Tyr Thr Leu Pro Ala Asp Pro Asp Thr Trp
805 810 815
Pro Ser Ala Ala Pro Ile Gly Pro Pro Ile Asp Asn Thr Arg Ile His
820 825 830
Leu Leu Asp Asp Ala Leu Arg Pro Val Pro Asp Gly Val Pro Gly Gln
835 840 845
Leu Cys Val Ala Gly Ile Gly Leu Ala Arg Gly Tyr Leu Ala Arg Pro
850 855 860
Glu Leu Thr Ala Glu Arg Trp Val Ala Gly Gly Val Thr Gly Glu Glu
865 870 875 880
Arg Leu Tyr Leu Thr Gly Asp Leu Ala Arg Arg Ala Pro Ser Gly Asp
885 890 895
Leu Asp Phe Leu Gly Arg Ile Asp Asp Gln Val Lys Ile Arg Gly Ile
900 905 910
Arg Ile Glu Pro Gly Glu Ile Glu Ser Val Leu Thr Glu Asp Ser Arg
915 920 925
Val Ala His Ala Ala Val Ser Val Arg Glu Asp Pro Arg Gly Glu Lys
930 935 940
Phe Leu Ala Ala Tyr Val Val Pro Thr Gly Gly Pro His Ala Val Pro
945 950 955 960
Ser Thr Gly Pro His Ala Ala Pro Ser Thr Gly Pro Arg Ala Val Pro
965 970 975
Ser Thr Gly Pro His Ala Ala Pro Thr Gly Pro Pro His Ala Ser Pro
980 985 990
Thr Ala Gly Gln Arg Val Gly Gly Leu Ala Thr Ser Pro Arg Glu Asp
995 1000 1005
Leu Ala Thr Ser Leu Arg Ala Gly Leu Ala Ala Arg Leu Pro Ala
1010 1015 1020
Tyr Leu Val Pro Ser Ser Val Thr Leu Val Asp Ala Leu Pro Arg
1025 1030 1035
Thr Thr Ser Gly Lys Val Asp Arg Arg Ala Leu Pro Glu Pro Glu
1040 1045 1050
Pro Val Pro Ala Ser Ala Gly Lys Thr Ala Pro Arg Thr Arg Ala
1055 1060 1065
Glu Arg Ala Val Cys Arg Thr Phe Gln Asp Val Leu Gly Val Pro
1070 1075 1080
Glu Val Gly Thr Asp Asp Asp Phe Phe Ala Leu Gly Gly His Ser
1085 1090 1095
Leu Leu Ala Thr Arg Val Ile Ala Arg Leu Arg Ala Gln Leu Gly
1100 1105 1110
Ala Asp Val Pro Leu Arg Thr Leu Phe Asp Ala Arg Thr Pro Ala
1115 1120 1125
Ala Leu Ala Arg Ala Val Asp Ala Ala Gly Pro Ala Ala Leu Pro
1130 1135 1140
Pro Val Leu Pro Ser Pro Gly Asp Gly Pro Val Pro Ile Thr Ala
1145 1150 1155
Ala Gln Glu Gln Met Leu His Ser His Gly Ser Leu Leu Ala Ala
1160 1165 1170
Pro Ser Tyr Thr Val Ala Pro Tyr Gly Phe Arg Leu Arg Gly Pro
1175 1180 1185
Leu Asp Arg Asp Ala Leu Asp Ala Ala Leu Thr Arg Ile Thr Ala
1190 1195 1200
Arg His Glu Pro Leu Arg Thr Gly Phe Arg Gly Arg Asp Gln Ile
1205 1210 1215
Val Arg Pro Pro Ala Ala Val Arg Ala Glu Val Val Glu Val Pro
1220 1225 1230
Ser Gly Asp Val Arg Ala Ala Val Leu Val Ala Arg Ala Glu Leu
1235 1240 1245
Thr Arg Pro Phe Asp Leu Val Asp Gly Pro Leu Leu Arg Ala Val
1250 1255 1260
Leu Leu Pro Leu Gly Ala Glu Asp His Val Leu Leu Leu Met Leu
1265 1270 1275
His His Leu Ala Gly Asp Gly Trp Ser Phe Asp Leu Leu Val Arg
1280 1285 1290
Glu Val Ser Gly Gly Ser Pro Gln Leu Pro Val Ser Tyr Thr Asp
1295 1300 1305
Val Ala Arg Trp Glu Arg Thr Pro Ala Val Val Ala Ala Arg Glu
1310 1315 1320
Ala Asp Arg Ala Tyr Trp Arg Gly Glu Leu Ala Gly Ala Ala Ala
1325 1330 1335
Pro Glu Leu Pro Ala Val Gly Pro Arg Ser Thr Thr Ala Pro Ala
1340 1345 1350
Gly Arg Ala Phe Leu Trp Thr Leu Asp Gly Ala Thr Val Asp Ala
1355 1360 1365
Ala Arg Leu Val Ala Glu Ala Gly Asn Ala Thr Leu His Glu Thr
1370 1375 1380
Val Leu Gly Ala Phe Ala Leu Val Val Ala Glu Ala Ala Asp Thr
1385 1390 1395
Asp Asp Val Leu Val Ala Thr Pro Phe Ala Asp Arg Gly Asn Ala
1400 1405 1410
Gly Thr Asp His Leu Ile Gly Phe Phe Ala Lys Val Leu Ala Leu
1415 1420 1425
Arg Ile Asp Val Gly Ser Asp Asn Ser Gly Gly Asp Arg His His
1430 1435 1440
His Arg His Thr Lys Ser Asp Ser Asp Ser Arg Asp Asp Asn Ser
1445 1450 1455
Gly Thr Pro Ser Phe Pro Glu Val Leu Arg Arg Val Arg Ser Ala
1460 1465 1470
Met Ala Gly Ala His Ala His Gln Ser Val Pro Tyr Ser Ala Met
1475 1480 1485
Arg Ala Ala Asp Pro Thr Leu Pro Pro Ala Pro Val Ser Phe Gln
1490 1495 1500
Leu Ile Ser Ala Leu Ser Thr Glu Leu Arg Leu Pro Gly Leu Arg
1505 1510 1515
Thr Glu Pro Phe Pro Val Val Ala Glu Thr Val Asp Glu Ile Asp
1520 1525 1530
Gly Glu Leu Ser Ile Asn Leu Phe Asp Asp Gly Arg Thr Val Ser
1535 1540 1545
Gly Ala Val Val His Asp Ala Ala Leu Leu Asp Arg Ala Thr Val
1550 1555 1560
Asp Asn Leu Leu Thr Arg Val Glu Ser Thr Leu Arg Thr Ala Ala
1565 1570 1575
Gly Asp Leu Thr Val Arg Val Thr Gly Gln Val Gly Ser Glu
1580 1585 1590
<210> 121
<211> 4779
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 121
gtgaagaatc gcgagaagaa gaatcaggaa atcgtcgccg ccgaccgcgc cgagccgtta 60
gtctcctcct tctcccagcg tcgaatctgg ttcctgcaac aattggaccc ggacagcaac 120
gcctacaatc tgccgctcgt acggcgtctg agggggccgc ttgacgcggc gcttctggag 180
cgcgcgctca cgctcgtcgt ggcgcggcac gaggcgttgc ggacggtgtt cgacgcctcg 240
gacggggacc ccgtccagcg ggtgcttccc gccccgaccc ggattctgcg ccacgcgcgg 300
gccgacggag agcagggcgc gggatcgctc gtgcgcgcgg agatcgccgc gcccttcact 360
ctctccaccg ggccactgat cagggctctg ctgatccgta tcggtgacga cgaccatgtc 420
ctcgcggtga ccgtgcacca tgtcgcgggc gacggctggt cgttcgggct gctccaactc 480
gaactcgccg cgcactacgc ggcgctccgc gacactgccg cgcccgccgt gctgccgccg 540
ttgccactcc agtacgccga cttcgccgct tgggaacggc gtgagctggc aggggccggg 600
ctcgaaaagc gcctggccta ctggcgtgaa cggctcaagg gcgccccgcc ggtgctcgat 660
ctgcccaccg accgtccccg cccacccgtg gccgacgcgg acgcggggct ggtcgaatgg 720
cgtccccccg ccgcactggc cacggccgtt ctccaactcg gacgcggcgc gggcacctcc 780
gtgttcatga ccctgctctc ggcgttccag ctcgtcctcg cccggcaggc cggcacacag 840
gacgtactgg tcggcacgcc cgtcgcgaac cgtacgcgaa ccgcgttcga gggcctcatc 900
ggcatgttcg tcaacacact cgtgctccgc ggcgacctct cgggcgaccc gacgttccgg 960
cagctcctcg accgctgccg ggccacgacc gccgacgcgt tcacccacgc cgacctgccg 1020
ttcgagaacc tgatcgaggt cgtcgcaccc gaccgcgacc tgtcggtcaa ccccgtcgta 1080
caggtgctgc tacaggtact gcggcgcgac gcgacgacgg ccgcactgcc aggcgtcacg 1140
tccgagccgt tcggcaccgg ccgctggttc acccggttcg acctggagtt ccatgtgtac 1200
gaggagtcgg acggcgtcct caccggtgaa ctcctctaca gtcgggcgct gttcgacgct 1260
tcgaggatca cgcggttact ggacgagttc acggccgtgc tgggggccgc caccgccgac 1320
ccgggcacac ggctctccca gctgcccgtc ggcggcgccg cgacgagtgc ccgcctcccc 1380
tcgaacgaca cggcacggga actgcccgtc gagacgctgc cggagttgct ggccaggtac 1440
gccgcgagaa cccccgacgc cgtggctgtc acggacccgc ggacctcgct cacgtacacg 1500
gagttggacc ggcgggcgaa ccgcctcgcg cacctgctcc gggcacgcgg taccgccacc 1560
ggcgacctcg tcgggatctg cgccgaccga ggcgtcgacc tgatcgtcgg catcgtgggg 1620
atcctcaagg cgggcgccgc gtacgtaccg ctcgatcccg aacaccccca ggaacgcacg 1680
gctttcgtcc ttgacgacgc gcggctgacc acggtggtga cgcacgaggc ctaccgtgcc 1740
cggttctccg ccgggccccg ggggctctcg gctgtgccac aggggacctc cgccgtgcca 1800
caggagtcct ccgccgtgtc acaggagtcc tccgccgtgt cacagggggc cttccccgta 1860
ccgcacgtgg tgacgctcga cgccccggac ctcgaccgcc ggccggacac tccgccgcac 1920
atcacgctcg accgggacag cctcgcctac gcgatctaca catccgggtc gaccggcagg 1980
cccaaggccg tgctcatgcc gggcgtcagc gccgtcaacc tgctgctctg gcaggaacgc 2040
acgatggggc gcgaggcgga cagccgcacc gtccagttcg tgaccgccac cttcgactac 2100
tcggtgcagg agatattctc cgccctgctc ggcggcacac tcgtcatccc acccgacgag 2160
gcacggttcg accccccggg cctggcccgc tggatggacg agcagcggat cacgcggatc 2220
tacgcgccca cggccgtgct gcgcgcgctg gtcgaacacg tcgatccgga cagcgatcag 2280
ctctccgcgc tccggcacct ctgccaaggt ggtgaggccc tgatcctcga cgcgcggctg 2340
cgtgaactct gccgccaccg gccccatttg cgcgtccaca accactacgg cccggccgag 2400
agccaactcg tcaccgggta caccctgccg gccgaccccg acacgtggcc gtccgcggca 2460
ccgatcggcc cgccgatcga caacacccgc atccatcttc tcgacgacgc gctgcggccg 2520
gttcctgacg gcgtgccggg gcagctctgc gtcgccggca tcggtctggc ccgcggatac 2580
ctcgcccgcc ccgaactgac cgccgagcga tgggtggcgg gcggcgtcac cggcgaggag 2640
cgtctgtatc tcaccgggga cctggcgcgc cgcgcgccct ccggcgacct ggacttcctc 2700
ggccggatcg acgaccaggt caagatccgc ggcatccgca tcgagcctgg tgagatcgag 2760
agcgtgctca ccgaggactc ccgcgtcgca cacgccgccg tctccgtacg cgaggatccg 2820
cggggcgaga agttcctggc cgcgtacgtg gtgccgaccg gcggcccaca tgccgtcccg 2880
tccaccggcc cgcacgccgc gccgtccacc ggcccacgcg ccgtcccgtc caccggcccg 2940
cacgccgcgc cgaccggccc cccgcatgcc tcgcccaccg caggtcagcg cgtcggcggc 3000
ctcgccacct cgccgcgtga agacctcgcc acttcgctgc gtgcaggtct cgccgcccgg 3060
ttgcccgcct atctcgtgcc gtcgtccgtc accctggtgg acgcgctgcc caggaccacg 3120
agcggcaagg tggaccggcg ggcgctgccc gagccggagc ccgtcccggc gtcggccggg 3180
aagaccgcgc cccgcactcg cgccgagcgc gcggtgtgcc ggaccttcca ggacgtgctc 3240
ggcgtccctg aggtcggtac cgacgacgat ttcttcgcac tcggcgggca ttccctgctc 3300
gccacacggg tcatcgcgcg gctccgcgcc cagctcggcg ccgacgtccc gctgcgcacg 3360
ctcttcgacg cgcggacacc cgccgcgctc gcccgcgcgg tggacgcggc agggcccgcc 3420
gccctgcccc cggtcctgcc ctcacccggc gacggtcccg tgcccatcac cgcggcgcag 3480
gaacagatgc tgcactcgca cggctcgctg ctcgccgcgc cttcctacac ggtcgcaccg 3540
tacgggttcc ggctgcgcgg gccgctcgac cgcgacgcgc tggacgcggc gctgacccgg 3600
atcaccgcgc ggcacgagcc gttgcgcacg gggttccggg gccgggatca gatcgtccgg 3660
ccacccgctg cggtgcgcgc cgaagtggtc gaggtgccgt ccggtgatgt ccgcgccgcg 3720
gtcctggtcg cccgcgcgga gttgaccagg cccttcgacc tcgtggacgg gccgttgctg 3780
cgtgccgtgc tcctgccgct cggcgcggag gatcacgtac tgctgctgat gttgcaccat 3840
ctcgccggtg acggctggtc gttcgatctc ctggtcaggg aggtgtccgg gggctcaccg 3900
cagctgccgg tctcctacac ggacgtggcc cgatgggagc ggaccccggc cgtggtcgcc 3960
gcacgggaag ccgaccgggc gtactggcgc ggcgagttgg cgggcgccgc cgctccggag 4020
ctgcccgcgg tcgggccccg ctccacgacc gcgccggccg ggcgggcatt cctctggacg 4080
ctcgacggtg ccacggtcga tgcggcacgc ctggtcgccg aggccgggaa cgccacgttg 4140
cacgagaccg tgctcggcgc cttcgccctg gtcgtggcgg aggccgccga caccgatgac 4200
gtactcgtcg cgacaccgtt cgcggaccgg gggaacgccg ggaccgacca cctcatcggc 4260
ttcttcgcga aggtgctcgc actgcgcatc gacgtcggca gcgacaacag cggcggcgac 4320
agacaccacc acaggcacac caagagcgac agcgacagcc gcgatgacaa cagcggcaca 4380
ccgtcgttcc ccgaggtcct gcggcgggtg cgctccgcga tggcaggcgc ccacgcccat 4440
cagtccgtcc cctactcggc gatgcgcgcg gcggacccca cgctgccgcc cgcccccgtg 4500
tcgttccagc tcatcagcgc gctcagcacg gaactgcggc tgccgggact gcgtaccgaa 4560
ccgtttcccg tcgtcgcgga gaccgtcgac gagatcgacg gcgaactgtc gatcaatctc 4620
ttcgacgacg gtcgcaccgt ctcgggcgcg gtcgtccacg acgccgcgct gctcgaccgc 4680
gcgaccgtcg acaacctgct cacccgggtg gagtcgacgc tgcgcaccgc cgcgggcgac 4740
ctcaccgtac gcgtcaccgg tcaagtggga agcgagtaa 4779
<210> 122
<211> 6449
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 122
Val Pro Glu Gln Asp Lys Thr Val Glu Tyr Leu Arg Trp Ala Thr Ser
1 5 10 15
Glu Leu Gln Arg Thr Arg Ala Glu Leu Ala Ala Arg Ser Glu Pro Leu
20 25 30
Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ala Ser Pro
35 40 45
Asp Asp Leu Trp Arg Leu Leu Asp Ser Glu Gly Asp Gly Ile Gly Ala
50 55 60
Phe Pro Ala Asp Arg Gly Trp Glu Thr Gly Ala Asp Gly Arg Gly Gly
65 70 75 80
Phe Leu Thr Gly Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Val Ser
85 90 95
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Val Leu Glu
100 105 110
Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro His Thr Leu
115 120 125
Ser Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Phe Phe Gln Gly Tyr
130 135 140
Gly Ile Gly Ala Asp Phe Asp Gly Tyr Gly Thr Thr Ser Ile His Thr
145 150 155 160
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro
165 170 175
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
180 185 190
Gln Ala Gly Gln Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val
195 200 205
Gly Gly Val Thr Val Leu Ala Ser Pro Ala Gly Phe Ala Asp Phe Ser
210 215 220
Glu Gln Gly Gly Leu Ala Gln Asp Gly Arg Cys Lys Ala Phe Ala Glu
225 230 235 240
Ala Ala Asp Gly Thr Ala Phe Ala Glu Gly Ser Gly Val Leu Val Val
245 250 255
Glu Arg Leu Ser Asp Ala Glu Arg Arg Gly His Arg Ile Leu Ala Val
260 265 270
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
275 280 285
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
290 295 300
Asn Ala Gly Leu Thr Pro Thr Asp Ile His Ala Val Glu Gly His Gly
305 310 315 320
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala
325 330 335
Thr Tyr Gly Gln Gln Arg Thr Thr Pro Leu Leu Leu Gly Ser Leu Lys
340 345 350
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile
355 360 365
Lys Met Ile Leu Ala Met His His Gly Thr Leu Pro Pro Thr Leu His
370 375 380
Val Asp Thr Pro Ser Ser His Val Ala Trp Thr Ala Gly Ala Val Glu
385 390 395 400
Leu Leu Thr Asp Ala Arg Pro Trp Pro Thr Thr Thr Gly Pro His Arg
405 410 415
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
420 425 430
Ile Glu Ser His Pro Gln Pro Ala Pro Ala Ala Pro Asp Thr Glu Pro
435 440 445
Gly Ala Arg Pro Val Pro Leu Leu Leu Ser Ala Arg Thr Pro Glu Ala
450 455 460
Leu Asp Ala His Thr Gly Arg Leu Arg Ala Phe Leu Arg Asp Asn Pro
465 470 475 480
Gly Ala Asp Arg Val Ala Ile Ala Gln Thr Leu Ala Arg Arg Thr Pro
485 490 495
Phe Glu His Arg Ala Val Leu Leu Gly Asp Thr Leu Ile Ala Ala Asp
500 505 510
Pro Asn Ala Gly Ser Gly Pro Val Val Phe Val Tyr Ser Gly Gln Ser
515 520 525
Thr Leu His Pro His Thr Gly Arg Gln Leu Ala Thr Thr Tyr Pro Val
530 535 540
Phe Ala Asp Val Trp Asp Glu Val Leu Gly His Leu Asp Pro Asp Gln
545 550 555 560
Gly Pro Ala Thr His Phe Ala His Gln Thr Ala Leu Thr Ala Leu Leu
565 570 575
Arg Ser Trp Gly Ile Thr Pro His Ala Val Ile Gly His Ser Leu Gly
580 585 590
Glu Ile Thr Ala Ala Cys Thr Ala Gly Val Leu Ser Leu Gly Asp Ala
595 600 605
Ser Ala Leu Leu Ala Ala Arg Ser Arg Leu Met Asp Lys Leu Pro Thr
610 615 620
Gly Gly Ala Met Val Thr Val Leu Thr Ser Glu Glu His Ala Leu Gly
625 630 635 640
Ala Leu Arg Pro Gly Val Glu Ile Ala Ala Val Asn Gly Pro His Ser
645 650 655
Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu Asp Val Ala Arg Gln
660 665 670
Leu Gly Ile His His Arg Leu Pro Thr Arg His Ala Gly His Ser Ala
675 680 685
Arg Met Glu Pro Leu Val Ala Pro Leu Leu Glu Ala Ala Arg Lys Leu
690 695 700
Thr Tyr His Gln Pro Arg Val Ala Val Pro Gly Asp Pro Thr Thr Ala
705 710 715 720
Glu Tyr Trp Ala Arg Gln Val Arg Asp Gln Val Arg Phe Gln Ala His
725 730 735
Thr Glu Arg Tyr Pro Gly Ala Thr Phe Leu Glu Ile Gly Pro Asn Gln
740 745 750
Asp Leu Ser Pro Val Ile Asp Gly Ile Pro Thr Gln Thr Gly Val Pro
755 760 765
Asp Glu Val Arg Ala Leu His Thr Ala Leu Ala His Leu Tyr Ile Arg
770 775 780
Gly Val Ala Ile Asp Trp Ala Ala Val Leu Gly Gly Asp Arg Ala Pro
785 790 795 800
Val Ala Leu Pro Thr Tyr Pro Phe Gln His Lys Asp Tyr Trp Leu Arg
805 810 815
Ala Thr Val Arg Ala Asp Val Thr Gly Ala Gly Gln Glu Lys Val Ala
820 825 830
His Pro Leu Leu Gly Ala Ser Val Ala Leu Pro Gly Ser Gly Gly Thr
835 840 845
Val Leu Thr Gly Arg Val Ser Leu Ala Ser His Pro Trp Leu Ala Gly
850 855 860
His Ala Val Asn Gly Ala Val Leu Leu Pro Gly Ala Ala Phe Leu Glu
865 870 875 880
Leu Ala Val Arg Ala Gly Asp Glu Ala Gly Cys Asp Leu Leu His Glu
885 890 895
Leu Val Val Glu Thr Pro Leu Ala Leu Pro Ala Thr Gly Ala Val Ala
900 905 910
Ile Ser Val Glu Val Ala Glu Ala Asp Asp Ala Gly Arg Arg Ala Leu
915 920 925
Thr Val His Ala Arg Val Glu Gly Gly Gly Leu Trp Thr Arg His Ala
930 935 940
Thr Gly Ser Leu Gly Lys Ala Ala Ser Thr Gly Ala Ala Thr Asp Pro
945 950 955 960
Ala Pro Trp Pro Pro Ala Gly Ala Leu Pro Val Glu Val Gly Asp Val
965 970 975
Tyr Glu Arg Phe Gly Gly Val Gly Tyr Ala Tyr Gly Pro Ser Phe Gln
980 985 990
Gly Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr Val His Ala Glu Val
995 1000 1005
Ala Leu Pro Glu Glu Leu Ser Ala Asp Ala Ala Arg Phe Thr Leu
1010 1015 1020
His Pro Ala Leu Leu Asp Ala Ala Phe Gln Ala Gly Ala Leu Pro
1025 1030 1035
Ala Leu Asp Ala Pro Gly Glu Ala Ala Arg Leu Pro Phe Ala Phe
1040 1045 1050
Gln Asp Val Arg Ile Phe Ala Ala Gly Ala Thr Arg Ala Arg Val
1055 1060 1065
Thr Val Gly Arg Glu Gly Asp Arg Gly Thr Val Thr Met Thr Gly
1070 1075 1080
Glu Asp Gly Gln Pro Val Ala Val Val Gly Ser Val Val Ser Arg
1085 1090 1095
Pro His Thr Gly Gly Thr Gly Thr Gly Thr Gly Ser Asp Gly Leu
1100 1105 1110
Leu Arg Pro Val Trp Thr Glu Leu Pro Met Pro Ala Pro Ser Ala
1115 1120 1125
Ser Asp Pro Arg Val Glu Val Phe Gly Ala Asp Pro Val Asp Gly
1130 1135 1140
Glu Pro Val Ser Ala Thr Arg Glu Leu Ala Gly Arg Val Leu Gly
1145 1150 1155
Ala Leu Gln Arg Arg Leu Ser Ala Thr Asp Asp Val Thr Leu Val
1160 1165 1170
Val Arg Val Ser Thr Gly Leu Ala Ala Ser Ala Ala Ala Gly Leu
1175 1180 1185
Val Arg Ser Ala Gln Ala Glu Asn Pro Gly Gly Val Val Leu Val
1190 1195 1200
Glu Ala Pro Pro Glu Thr Pro Thr Asp Leu Leu Ala Ala Cys Ala
1205 1210 1215
Ala Leu Glu Glu Pro Trp Leu Ala Val Arg Asp Gly Val Leu His
1220 1225 1230
Ala Pro Arg Leu Val Arg Met Ser Asp Pro Val His Gly Pro Leu
1235 1240 1245
Pro Leu Pro Asp Gly Asp Trp Leu Leu Thr Arg Ser Ala Ser Gly
1250 1255 1260
Val Leu His Asp Val Ala Leu Thr Ala Asp Gly Ala Pro Arg Arg
1265 1270 1275
Ala Leu Glu Ala Gly Glu Val Arg Val Gly Val Arg Ala Ala Gly
1280 1285 1290
Leu Asn Phe Arg Asp Val Leu Ile Ala Leu Gly Thr Tyr Asp Gly
1295 1300 1305
Ala Thr Thr Met Gly Gly Glu Ala Ala Gly Val Val Val Glu Thr
1310 1315 1320
Gly Pro Gly Val Ala Asp Leu Ser Pro Gly Asp Arg Val Phe Gly
1325 1330 1335
Leu Thr Arg Gly Gly Ile Gly Pro Thr Ala Val Thr Asp Arg Arg
1340 1345 1350
Trp Leu Ala Arg Ile Pro Asp Gly Trp Ser Phe Thr Thr Ala Ala
1355 1360 1365
Ser Val Pro Ile Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp
1370 1375 1380
Leu Ala Gly Val Arg Glu Gly Glu Lys Val Leu Val His Ala Gly
1385 1390 1395
Thr Gly Gly Val Gly Met Ala Ala Thr Arg Ile Ala Arg His Leu
1400 1405 1410
Gly Ala Glu Val Tyr Ala Thr Ala Gly Thr Gly Lys Gln His Val
1415 1420 1425
Leu Arg Ala Ser Gly Leu Pro Asp Thr His Ile Ala Asp Ser Arg
1430 1435 1440
Thr Thr Ala Phe Arg Thr Ala Phe Pro Arg Met Asp Val Val Leu
1445 1450 1455
Asn Ser Leu Thr Gly Glu Phe Ile Asp Ala Ser Leu Glu Leu Leu
1460 1465 1470
Asp Ala Gly Gly Arg Phe Val Glu Met Gly Arg Ala Glu Leu Arg
1475 1480 1485
Asp Pro Ala Thr Ile Ile Pro Ala Tyr Leu Pro Phe Asp Leu Met
1490 1495 1500
Asp Ala Gly Thr Asp Arg Ile Gly Glu Ile Leu Gly Glu Leu Leu
1505 1510 1515
Thr Leu Phe Asp Thr Gly Ala Leu Ser Pro Leu Pro Val Arg Ala
1520 1525 1530
Trp Asp Val Arg Gln Ala Arg Glu Ala Leu Gly Trp Met Ser Arg
1535 1540 1545
Ala Arg His Ile Gly Lys Asn Val Leu Thr Leu Pro Arg Pro Leu
1550 1555 1560
Asp Pro Glu Gly Ala Val Val Ile Thr Gly Gly Ser Gly Thr Leu
1565 1570 1575
Ala Gly Ile Leu Ala Arg His Leu Ser Gly Leu His Val Tyr Leu
1580 1585 1590
Leu Ser Arg Thr Ala Pro Pro Glu Asp Thr Pro Gly Thr His Leu
1595 1600 1605
Ser Cys Asp Val Gly Asp Arg Ala Gln Leu Ala Ser Ala Leu Ser
1610 1615 1620
Arg Ile Asp Arg Pro Ile Thr Ala Val Val His Thr Ala Gly Val
1625 1630 1635
Leu Asp Asp Gly Thr Val Pro Ser Leu Thr Pro Glu Arg Leu Asp
1640 1645 1650
Thr Val Leu Arg Pro Lys Ala Asp Gly Ala Trp His Leu His Gln
1655 1660 1665
Leu Thr Glu Asp Gln Asp Leu Ala Ala Phe Val Leu Tyr Ser Ser
1670 1675 1680
Ala Ala Gly Val Leu Gly Asn Ala Gly Gln Gly Asn Tyr Val Ala
1685 1690 1695
Ala Asn Ala Phe Leu Asp Ala Leu Ala Glu Leu Arg His Ala Ala
1700 1705 1710
Gly Leu Pro Ala Leu Ser Ile Gly Trp Gly Leu Trp Glu Asp Ala
1715 1720 1725
Ser Gly Leu Thr Ala Ala Leu Ser Glu Ala Asp Arg Asp Arg Met
1730 1735 1740
Arg Arg Ser Gly Phe Arg Thr Ile Thr Ala Pro His Gly Met Arg
1745 1750 1755
Leu Phe Glu Ala Ala Arg Arg Thr Gly Thr Pro Val Val Val Ala
1760 1765 1770
Ala Glu Leu Asp Asp Ala Pro Asp Val Pro Leu Leu Arg Gly Leu
1775 1780 1785
Arg Arg Thr Thr Val Arg Arg Ala Thr Val Arg Glu Arg Ser Leu
1790 1795 1800
Ala Asp Arg Leu Ala Ala Leu Ser Asp Asp Glu Arg Ala Asp Ala
1805 1810 1815
Leu Leu Ala Leu Val Arg Asp Ser Thr Ala Thr Val Leu Gly His
1820 1825 1830
Leu Gly Ala Glu Glu Ile Pro Gly Thr Thr Thr Phe Lys Glu Leu
1835 1840 1845
Gly Ile Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Thr Leu Thr
1850 1855 1860
Thr Ala Thr Gly Val Arg Leu Asn Ala Thr Ala Val Phe Asp Phe
1865 1870 1875
Pro Thr Pro Arg Ala Leu Ala Val Arg Leu Gly Gly Glu Leu Thr
1880 1885 1890
Gly Ile His Ala Pro Val Ala Ala Arg Thr Ala Ala Thr Ala Val
1895 1900 1905
Ala His Asp Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu
1910 1915 1920
Pro Gly Gly Val Ala Ser Pro Asp Asp Leu Trp Arg Leu Val Ala
1925 1930 1935
Ser Gly Thr Asp Ala Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp
1940 1945 1950
Asp Val Asp Ala Leu Tyr Asp Pro Asp Pro Asp Ala Ile Gly Lys
1955 1960 1965
Thr Phe Val Lys His Gly Gly Phe Leu Asp Gly Ala Thr Gly Phe
1970 1975 1980
Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met
1985 1990 1995
Asp Pro Gln Gln Arg Val Leu Leu Glu Thr Ser Trp Glu Ala Phe
2000 2005 2010
Glu Ser Ala Gly Ile Thr Pro Glu Ser Ala Arg Gly Ser Asp Thr
2015 2020 2025
Gly Val Phe Ile Gly Ala Phe Ser Tyr Gly Tyr Gly Ala Gly Ala
2030 2035 2040
Asp Thr Asn Gly Phe Gly Ala Thr Gly Ser Gln Thr Ser Val Leu
2045 2050 2055
Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ser Val
2060 2065 2070
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
2075 2080 2085
Ala Gly Gln Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val
2090 2095 2100
Gly Gly Val Thr Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe
2105 2110 2115
Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe
2120 2125 2130
Gly Ala Gly Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Ala
2135 2140 2145
Leu Ile Val Lys Arg Leu Ser Asp Ala Glu Arg Asp Gly His Thr
2150 2155 2160
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala
2165 2170 2175
Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ala Gln Glu Arg Val
2180 2185 2190
Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Thr Thr Ala Asp Val
2195 2200 2205
Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro
2210 2215 2220
Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Asp Arg Ala
2225 2230 2235
Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala
2240 2245 2250
Gln Ala Ala Ser Gly Val Ala Gly Ile Ile Lys Thr Val Gln Ala
2255 2260 2265
Ile Arg His Gly Glu Leu Pro Pro Thr Leu His Ala Asp Glu Pro
2270 2275 2280
Ser Pro His Val Asp Trp Thr Ser Gly Ala Val Glu Leu Leu Thr
2285 2290 2295
Ser Ala Arg Pro Trp Pro Arg Thr Gly Arg Pro Arg Arg Ala Ala
2300 2305 2310
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu
2315 2320 2325
Glu Ala Gly Pro Asp Gln Glu Glu Pro Ser Ala Glu Pro Ala Gly
2330 2335 2340
Asp Leu Pro Leu Leu Val Ser Ala Arg Ser Pro Glu Ala Leu Asp
2345 2350 2355
Glu Gln Ile Gly Arg Leu Arg Asp Tyr Leu Asp Ala Ala Pro Gly
2360 2365 2370
Val Asp Leu Ala Ala Val Ala Arg Thr Leu Ala Thr Arg Thr His
2375 2380 2385
Phe Ser His Arg Ala Val Leu Leu Gly Asp Thr Val Ile Thr Ala
2390 2395 2400
Pro Pro Val Glu Gln Pro Gly Glu Leu Val Phe Val Tyr Ser Gly
2405 2410 2415
Gln Gly Thr Gln His Pro Ala Met Gly Glu Arg Leu Ala Ala Ala
2420 2425 2430
Phe Pro Val Phe Ala Glu Thr Trp His Asp Ala Leu Arg Arg Leu
2435 2440 2445
Gly Asp Pro Asp Pro His Asp Pro Thr His Ser Gln His Thr Leu
2450 2455 2460
Phe Ala His Gln Ala Ala Phe Thr Ala Leu Leu Arg Ser Trp Ala
2465 2470 2475
Val Thr Pro Asp Ala Val Ile Gly His Ser Leu Gly Glu Ile Thr
2480 2485 2490
Ala Ala Tyr Ala Ala Gly Val Leu Ser Leu Gly Asp Ala Cys Thr
2495 2500 2505
Leu Val Thr Thr Arg Ala Arg Leu Met His Thr Leu Pro Pro Pro
2510 2515 2520
Gly Ala Met Val Thr Val Leu Thr Ser Glu Asp Glu Ala Arg His
2525 2530 2535
Ala Leu Arg Thr Gly Val Glu Ile Ala Ala Val Asn Gly Pro His
2540 2545 2550
Ser Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu Ala Val Ala
2555 2560 2565
Gln Gly Leu Gly Ile His His Arg Leu Pro Ala Pro His Ala Gly
2570 2575 2580
His Ser Ser His Met Glu Pro Val Ala Ala Glu Leu Leu Ala Thr
2585 2590 2595
Thr Arg Gly Leu Thr Tyr Gly Arg Pro His Thr Ala Ile Pro Asn
2600 2605 2610
Asp Pro Thr Thr Ala Glu Tyr Trp Ala Glu Gln Val Arg Glu Pro
2615 2620 2625
Val Leu Phe His Ala His Ala Gln Arg Tyr Pro Asp Ala Leu Phe
2630 2635 2640
Val Glu Ile Gly Pro Gly Gln Asp Leu Ala Pro Leu Val Asp Gly
2645 2650 2655
Val Ala Leu Gln Asn Gly Thr Ala Asp Glu Val His Ala Leu His
2660 2665 2670
Thr Ala Leu Ala Arg Leu Tyr Thr Arg Gly Ala Thr Leu Asp Trp
2675 2680 2685
Pro Arg Ile Leu Gly Gly Thr Ala Arg His Asp Pro Asp Val Pro
2690 2695 2700
Ala Tyr Ala Phe Gln Arg Arg Pro Tyr Trp Ile Glu Ser Ala Pro
2705 2710 2715
Pro Val Thr Ala Asp Ala Gly His Pro Val Leu Gly Thr Gly Ile
2720 2725 2730
Thr Leu Ala Gly Ser Pro Gly Gln Val Phe Thr Gly Pro Val Pro
2735 2740 2745
Ala Gly Ala Asp Arg Ala Val Phe Val Ala Glu Leu Ala Leu Ala
2750 2755 2760
Ala Ala Asp Ala Thr Arg Cys Ala Thr Val Glu Arg Leu Asp Ile
2765 2770 2775
Ala Ser Val Pro Arg Pro Ser Val Gly Gly Gly Val Thr Ala Gln
2780 2785 2790
Ile Trp Val Asp Asp Pro Ser Ala Asp Gly Arg Arg Arg Phe Thr
2795 2800 2805
Val His Thr Arg Thr Gly Asp Ala Pro Trp Thr Pro His Ala Glu
2810 2815 2820
Gly Val Leu Arg Pro Gly Glu Val Pro Leu Pro Glu Ala Val Asp
2825 2830 2835
Thr Ala Trp Pro Pro Pro Gly Ala Val Pro Ala Asp Gly Ala Pro
2840 2845 2850
Gly Ala Trp Arg Arg Gly Asp Gln Val Phe Val Glu Ala Glu Val
2855 2860 2865
Asp Ser Pro Asp Gly Phe Val Ala His Pro Asp Leu Leu Asp Ala
2870 2875 2880
Val Leu Ser Ala Val Gly Ser Gly Ser Arg Gln Pro Thr Arg Trp
2885 2890 2895
Arg Asp Leu Ala Val His Ala Ser Asp Ala Thr Val Leu Arg Ala
2900 2905 2910
Arg Leu Thr Arg Arg Ala Gly Gly Ala Val Glu Leu Ala Ala Phe
2915 2920 2925
Asp Gly Ala Gly Leu Pro Val Leu Thr Ala Glu Ala Val Thr Leu
2930 2935 2940
Gly Glu Val Ala Ser Ala Gly Glu Ser Ala Arg Ser Asp Gly Leu
2945 2950 2955
Leu Arg Ile Glu Trp Val Pro Leu Ala Glu Ala Asp Tyr Asp Gly
2960 2965 2970
Asp Leu Pro Asp Asn Tyr Thr Leu Ile Thr Ala Ala His Pro Asp
2975 2980 2985
Asp Pro Thr Asp Pro Asn Asn Thr Pro Thr Arg Thr His Thr Gln
2990 2995 3000
Thr Thr Arg Val Leu Thr Ala Leu Gln His His Leu Thr Thr Thr
3005 3010 3015
His His Thr Leu Ile Val His Thr Thr Thr Asp Pro Ala Gly Ala
3020 3025 3030
Ala Val Thr Gly Leu Thr Arg Thr Ala Gln Asn Glu His Pro Gly
3035 3040 3045
Arg Ile His Leu Ile Glu Thr Pro His Pro His Thr Pro Leu Pro
3050 3055 3060
Leu Asn Gln Leu Thr Thr Leu Asn Gln Pro His Leu Arg Leu Thr
3065 3070 3075
His His Thr Leu His Thr Pro His Leu Thr Pro Leu Pro Thr Thr
3080 3085 3090
Thr His His Thr Pro Pro Leu Asn Pro His His Ala Ile Leu Ile
3095 3100 3105
Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Leu Ala Arg His Leu
3110 3115 3120
Asn His Pro His Thr Tyr Leu Leu Ser Arg Thr Pro Pro Pro His
3125 3130 3135
Thr Thr Pro Gly Thr His Ile Pro Cys Asp Ile Thr Asp Pro Thr
3140 3145 3150
Gln Leu Thr Thr Ala Leu His His Ile Pro Gln Pro Leu Thr Gly
3155 3160 3165
Ile Phe His Thr Ala Gly Thr Leu Asn Asp Ala Thr Leu Asp His
3170 3175 3180
Gln Thr Pro His His Leu Thr Thr Thr Leu Gln Pro Lys Ala Asp
3185 3190 3195
Ala Ala Trp His Leu His His Leu Thr Gln His Gln Pro Leu Thr
3200 3205 3210
His Phe Val Leu Tyr Ser Ser Ala Ala Ala Thr Leu Gly Ser Pro
3215 3220 3225
Gly Gln Ala Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala Leu
3230 3235 3240
Ala Thr His Arg His Thr His His Gln Pro Ala Thr Thr Ile Ala
3245 3250 3255
Trp Gly Met Trp Gln Thr Thr Ser Thr Leu Thr Gln His Leu Thr
3260 3265 3270
Thr Thr Glu Arg Asp Arg Ile Arg Arg Gly Gly Phe Leu Pro Ile
3275 3280 3285
Ser Asp Glu Glu Gly Met Arg Leu Tyr Asp Ala Ala Val Gly Ser
3290 3295 3300
Gly Glu Ala Phe Val Met Ala Ala Ala Met Asp Leu Ser Gln Pro
3305 3310 3315
Met Ala Gly Asp Val Pro Pro Ile Leu Ser Gly Leu Arg Arg Ser
3320 3325 3330
Ala Arg Arg Thr Ala Arg Ala Gly Gln Thr Phe Thr Gln Arg Leu
3335 3340 3345
Ala Glu Leu Pro Ala Ala Asp Arg Asp Thr Ala Leu Val Thr Leu
3350 3355 3360
Val Ser Asp Ala Thr Ala Thr Val Leu Gly His Ala Asp Ala Ser
3365 3370 3375
Ala Ile Ala Pro Thr Thr Thr Phe Lys Asp Leu Gly Ile Asp Ser
3380 3385 3390
Leu Thr Ala Ile Glu Leu Arg Asn Arg Leu Ala Glu Ala Thr Gly
3395 3400 3405
Leu Arg Leu Ser Ala Thr Met Val Phe Asp His Pro Thr Pro Arg
3410 3415 3420
Val Leu Ala Ala Glu Leu Arg Thr Asp Leu Phe Gly Thr Ala Val
3425 3430 3435
Pro Leu Pro Ala Arg Thr Thr Arg Ala Arg Asp Asp Glu Pro Leu
3440 3445 3450
Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Thr Ser
3455 3460 3465
Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala Ile
3470 3475 3480
Thr Glu Phe Pro Asp Asp Arg Gly Trp Asp Ile Asp Arg Met Phe
3485 3490 3495
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Val Arg His Gly
3500 3505 3510
Gly Phe Leu Ser Glu Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly
3515 3520 3525
Ile Ser Pro Arg Glu Ala Trp Ala Met Asp Pro Gln Gln Arg Val
3530 3535 3540
Ile Leu Glu Thr Val Trp Glu Ala Phe Glu Asn Ala Gly Ile Val
3545 3550 3555
Pro Asp Thr Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala
3560 3565 3570
Phe Ser His Gly Tyr Gly Ala Gly Val Asp Leu Gly Gly Phe Gly
3575 3580 3585
Ala Thr Ala Thr Gln Asn Ser Val Leu Ser Gly Arg Leu Ser Tyr
3590 3595 3600
Phe Phe Gly Met Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys
3605 3610 3615
Ser Ser Ser Met Val Ala Leu His Gln Ala Ala Gln Ser Leu Arg
3620 3625 3630
Asp Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val Met
3635 3640 3645
Pro Thr Pro Leu Gly Tyr Val Glu Phe Cys Arg Gln Arg Gly Leu
3650 3655 3660
Ala Pro Asp Gly Arg Ala Lys Ala Phe Ala Glu Gly Ala Asp Gly
3665 3670 3675
Thr Ser Phe Ser Glu Gly Ser Gly Val Leu Val Val Glu Arg Leu
3680 3685 3690
Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Leu Val Arg
3695 3700 3705
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser Ala
3710 3715 3720
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp
3725 3730 3735
Lys Ala Gly Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala His
3740 3745 3750
Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala Gln Ala Ile
3755 3760 3765
Ile Ala Thr Tyr Gly Gln Asp Arg Asp Thr Pro Leu Tyr Leu Gly
3770 3775 3780
Ser Val Lys Ser Asn Ile Gly His Thr Gln Thr Thr Ala Gly Leu
3785 3790 3795
Ala Gly Val Ile Lys Met Val Met Ala Met Arg His Gly Val Leu
3800 3805 3810
Pro Lys Thr Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp
3815 3820 3825
Ser Ala Gly Ala Val Glu Leu Leu Thr Glu Ala Arg Pro Trp Pro
3830 3835 3840
Gly Ser Gly Arg Pro Arg Arg Ala Gly Val Ser Ser Leu Gly Ile
3845 3850 3855
Ser Gly Thr Asn Ala His Val Ile Leu Glu Gly Val Glu Gly Pro
3860 3865 3870
Pro Ser Gly Leu Gly Pro Ser Ala Thr Cys Cys Thr Gly Ala Ser
3875 3880 3885
Ser Gly Ala Glu Pro Ser Ala Gly Ala Glu Ser Ser Gly Leu Gly
3890 3895 3900
Ala Gly Ser Pro Gly Ala Gly Ala Asp Ala Asp Arg Gly Leu Gly
3905 3910 3915
Pro Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala
3920 3925 3930
Ser Leu Val Glu Arg Leu Asp Ala Tyr Val Arg Gly Gly Leu Ser
3935 3940 3945
Val Gly Gly Asp Leu Gly Gly Val Ala Asp Gly Leu Val Arg Gly
3950 3955 3960
Arg Ala Val Phe Gly His Arg Ala Val Leu Leu Gly Glu Ser Arg
3965 3970 3975
Val Ala Gly Val Ala Val Asp Gly Leu Arg Thr Val Phe Val Phe
3980 3985 3990
Pro Gly Gln Gly Ser Gln Trp Thr Gly Met Gly Val Glu Leu Met
3995 4000 4005
Ser Ala Ser Glu Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala
4010 4015 4020
Ala Leu Glu Pro Phe Thr Gly Trp Asp Val Arg Asp Met Leu Ala
4025 4030 4035
Asp Ser Ala Val Leu Glu Arg Val Glu Val Leu Gln Pro Ala Ser
4040 4045 4050
Trp Ala Val Ala Val Ser Leu Ala Ala Leu Trp Arg Ala His Gly
4055 4060 4065
Val Val Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala
4070 4075 4080
Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Glu Asp Gly Ala Arg
4085 4090 4095
Ile Val Ala Arg Arg Ser Arg Ser Ile Ala Ala Arg Leu Ala Gly
4100 4105 4110
His Gly Ala Met Ala Ser Ile Ala Leu Ser Ala Ser Glu Val Glu
4115 4120 4125
Thr Pro Glu Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ser
4130 4135 4140
Thr Val Ile Ala Gly Glu Pro Glu Ala Val Glu Gln Val Leu Ala
4145 4150 4155
Arg Tyr Glu His Asp Gly Val Arg Val Arg Arg Ile Ala Val Asp
4160 4165 4170
Tyr Ala Ser His Thr Pro His Val Glu Ala Ile Glu Asp Glu Leu
4175 4180 4185
Ala Glu Ala Leu Glu Gly Ile Thr Ser Arg Ala Pro Thr Val Pro
4190 4195 4200
Trp Trp Ser Thr Leu Asp Ser Gly Trp Ile Ser Glu Pro Val Glu
4205 4210 4215
Asp Gly Tyr Trp Tyr Arg Asn Leu Arg Trp Pro Val Ala Met Asp
4220 4225 4230
Thr Ala Val Arg Glu Leu Asp Gly Ser Leu Phe Leu Glu Cys Ser
4235 4240 4245
Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Pro His Thr Val
4250 4255 4260
Ala Ser Leu Arg Thr Gly Asp Gly Gly His Pro Arg Phe Val Thr
4265 4270 4275
Ala Leu Ala Glu Ala Trp Thr Gln Gly Ala Pro Val Asp Trp Thr
4280 4285 4290
Thr Leu Ile Thr Pro Val Thr Pro Thr Ala Arg Leu Leu Asp Leu
4295 4300 4305
Pro Thr Tyr Pro Phe Asp His Lys Arg Tyr Trp Ile Glu Ala Thr
4310 4315 4320
Thr Thr Pro Asp Leu Thr Ala Leu Gly Leu Thr Asp Thr Ala His
4325 4330 4335
Pro Met Leu Ala Ala Thr Thr Ala Leu Pro Thr Thr Asp Gly Thr
4340 4345 4350
Val Leu Thr Gly Arg Ile Ser Leu Arg Thr His Pro Trp Leu Ala
4355 4360 4365
Asp His Thr Ile Gln Asp Thr Val Leu Leu Pro Gly Thr Ala Phe
4370 4375 4380
Leu Glu Leu Ala Val Arg Ala Gly Asp Glu Thr Gly Cys Asp Thr
4385 4390 4395
Ile Asp Glu Leu Val Ile Glu Thr Pro Leu Thr Leu Pro Ala Thr
4400 4405 4410
Thr Ala Val Asp Leu Thr Leu Thr Ile Asp Pro Pro Asp Thr Thr
4415 4420 4425
Gly His His Pro Leu Thr Ile His Ala Arg Pro Glu Gly Thr His
4430 4435 4440
Thr Trp Thr Arg His Ala Thr Gly Thr Leu Thr Asn Thr Thr Thr
4445 4450 4455
Asp Pro His Ala Pro Ala Thr Thr Asp Val Pro Ala Gly Leu Asp
4460 4465 4470
Val Pro Asp Pro Asp Thr Phe Arg His Trp Pro Pro Thr Gly Ala
4475 4480 4485
Thr Ala Met Asp Ile Thr Glu Phe Tyr Pro Arg Leu Ser Ala Leu
4490 4495 4500
Gly Tyr Arg Phe Gly Pro Thr Phe Arg Gly Leu Arg Ala Ala Trp
4505 4510 4515
Arg Asp Gly Asp Thr Val Tyr Ala Glu Val Ala Leu Pro Glu Asp
4520 4525 4530
Arg Ala Ala Asp Ala Asp Arg Tyr Gly Val His Pro Ala Leu Leu
4535 4540 4545
Asp Ala Ala Leu Gln Ser Gly Ser Leu Leu Met Glu Lys Gly Glu
4550 4555 4560
Gly Glu Gln Gly Val Gln Leu Pro Phe Ser Trp His Gly Val Arg
4565 4570 4575
Phe His Ala Ile Gly Ala Thr Ser Leu Arg Val Ala Ile Val Pro
4580 4585 4590
Gly Pro Asp Gly Leu Arg Leu Arg Ala Ala Asp Ser Glu Asn His
4595 4600 4605
Pro Val Val Thr Ile Asp Ala Leu Val Thr Arg Pro Pro Ala Asp
4610 4615 4620
Leu Ala Pro Ala Glu Pro Val Leu Arg Val Gly Trp Ala Ala Val
4625 4630 4635
Pro Val Pro Ala Glu Val His Pro Ser Asp Ala Asp Val Leu Thr
4640 4645 4650
Leu His Ser Asp Asp Ala Asp Pro Val Gln Glu Thr Arg Gln Leu
4655 4660 4665
Thr Thr Arg Ala Leu Asp Ala Leu Leu Leu Ala Glu Arg Thr Leu
4670 4675 4680
Ile Val Gln Ala Thr Gly Gly Leu Ala Thr Met Ala Ala Ala Gly
4685 4690 4695
Leu Val Arg Thr Ala Gln Asn Glu Gln Pro Gly Arg Phe Phe Leu
4700 4705 4710
Val Glu Thr Asp Ala Gly Val Val Leu Asp Ser Ser Arg Arg Asp
4715 4720 4725
Leu Ile Val Ala Leu Gly Glu Pro Arg Leu Arg Leu Arg Gly Asp
4730 4735 4740
Arg Phe Glu Ala Ala Arg Leu Met Arg Ala Ala Pro Ala Leu Thr
4745 4750 4755
Pro Pro Ala Thr Gly Ser Trp Gln Leu Arg His Ser Ala Thr Gly
4760 4765 4770
Ser Leu Asp Asp Leu Ala Leu Val Pro Thr Asp Gly Pro Asp Arg
4775 4780 4785
Pro Leu Ala Ala Gly Glu Val Arg Ile Ala Val Arg Ala Ala Gly
4790 4795 4800
Leu Asn Phe Arg Asp Val Thr Val Ala Leu Gly Val Val Ala Asp
4805 4810 4815
Thr Arg Pro Leu Gly Ser Glu Ala Ala Gly Val Val Leu Glu Thr
4820 4825 4830
Gly Pro Gly Val His Asp Leu Ala Pro Gly Asp Arg Val Leu Gly
4835 4840 4845
Met Leu Ala Gly Ala Phe Gly Pro Val Ala Ile Ala Asp Arg Arg
4850 4855 4860
Leu Leu Gly Arg Met Pro Asp Gly Trp Thr Tyr Pro Gln Ala Ala
4865 4870 4875
Ser Val Val Thr Val Phe Ala Thr Ala Trp Tyr Gly Leu Val Asp
4880 4885 4890
Leu Ala Lys Leu Arg Pro Gly Glu Lys Ile Leu Ile His Ala Ala
4895 4900 4905
Ala Thr Gly Val Gly Ala Ala Ala Val Gln Ile Ala Arg His Leu
4910 4915 4920
Gly Ala Asp Ile Tyr Ala Thr Ala Gly Ala Pro Lys Gln His Leu
4925 4930 4935
Val Asp Leu Asp Asp Ala Thr His Leu Ala Asp Ser Arg Thr Pro
4940 4945 4950
Glu Met Thr Ala Thr Phe Pro Pro Val Asp Val Val Leu Asn Ser
4955 4960 4965
Leu Thr Gly Asp Leu Leu Asp Ala Ser Val Ala Leu Leu Ala Pro
4970 4975 4980
Gly Gly Arg Phe Ile Glu Leu Gly Lys Thr Asp Leu Arg His Thr
4985 4990 4995
Val Gln Gln Pro Phe Asp Leu Val Asp Ala Gly Pro Asp Arg Leu
5000 5005 5010
Gln Gln Ile Ile Thr Glu Leu Leu Gly Leu Phe Ala Asp Asn Thr
5015 5020 5025
Leu His Pro Leu Pro Val Arg Ala Trp Asp Val Arg Arg Ala Arg
5030 5035 5040
Glu Ala Phe Gly Leu Met Ser Ser Gly Arg His Thr Gly Lys Ser
5045 5050 5055
Val Leu Thr Val Pro Arg Pro Leu Asp Pro Glu Gly Ala Val Leu
5060 5065 5070
Ile Thr Gly Gly Ser Gly Thr Leu Ala Gly Ile Leu Ala Arg His
5075 5080 5085
Leu Asp His Pro His Thr Tyr Leu Leu Ser Arg Thr Pro Pro Pro
5090 5095 5100
Asp Thr Thr Pro Gly Thr His Ile Pro Cys Asp Val Ser Asp Pro
5105 5110 5115
Thr Gln Leu Thr Thr Ala Leu His His Ile Pro Gln Pro Leu Thr
5120 5125 5130
Gly Ile Phe His Thr Ala Gly Thr Leu Asp Asp Ala Leu Leu Asp
5135 5140 5145
His Leu Thr Pro His Arg Val Asp Thr Val Leu Lys Pro Lys Ala
5150 5155 5160
Asp Ala Ala Trp His Leu His His Leu Thr Gln His Thr Asp Leu
5165 5170 5175
Ala Ala Phe Val Leu Tyr Ser Ala Val Ala Gly Val Met Gly Ser
5180 5185 5190
Pro Gly Gln Gly Asn Tyr Val Ala Ala Asn Ala Phe Leu Asp Ala
5195 5200 5205
Leu Ala Glu His Arg Gln Ser Met Gly Leu Pro Ala Gln Ser Leu
5210 5215 5220
Ala Trp Gly Met Trp Ala Asp Val Ser Ala Leu Thr Ala Lys Leu
5225 5230 5235
Thr Ala Ala Asp Arg Asp Arg Ile Arg Leu Ser Gly Phe Pro Pro
5240 5245 5250
Leu Ser Ala Glu Asp Gly Met Arg Gln Phe Asp Ala Ala Arg Arg
5255 5260 5265
Thr Pro Glu Pro Val Val Val Ser Thr Thr Val Asp Val Thr Arg
5270 5275 5280
Leu Asp Ala Gly Gln Val Ala Pro Leu Leu Arg Gly Leu Val Ala
5285 5290 5295
His Arg Gly Gly Pro Leu Arg Ala Ser Ala Arg Asn Ala Gly Asp
5300 5305 5310
Glu Pro Leu Ala Val Arg Leu Ala Gly His Thr Val Ala Glu Gln
5315 5320 5325
Arg Arg Val Met Gln Glu Val Val Leu Arg Gln Ala Ala Ala Val
5330 5335 5340
Leu Ala Tyr Gly Pro Gly Glu Gln Val Ala Ala Asp Arg Pro Phe
5345 5350 5355
Arg Glu Leu Gly Phe Asp Ser Leu Thr Ala Val Asp Leu Arg Asn
5360 5365 5370
Arg Leu Ala Ala Glu Thr Gly Leu Arg Leu Pro Thr Thr Val Val
5375 5380 5385
Phe Ser His Pro Thr Ala Asp Ser Leu Ala Thr His Leu Leu Glu
5390 5395 5400
Leu Leu Asp Ala Arg Ala Ala Glu Ala Val Gly Ala Ser Leu Pro
5405 5410 5415
Ser Val Ala Ala Glu Pro Ala Thr Ala Val Arg Asp Gln Asp Glu
5420 5425 5430
Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val
5435 5440 5445
Thr Ser Pro Glu Gly Leu Arg Gln Leu Val Glu Ser Gly Thr Asp
5450 5455 5460
Ala Ile Thr Leu Val Pro Leu Glu Arg Gly Trp Asp Leu Asp Ala
5465 5470 5475
Leu Tyr Asp Pro Asp Pro Asp Ala Val Gly Arg Ala Tyr Ser Leu
5480 5485 5490
Arg Gly Gly Phe Leu Glu Gly Ala Ala Glu Phe Asp Ala Ala Phe
5495 5500 5505
Phe Asp Ile Ser Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln
5510 5515 5520
Arg Leu Leu Leu Glu Thr Ala Trp Glu Ala Ile Glu Arg Gly Arg
5525 5530 5535
Ile Asn Pro Ala Ser Leu His Gly Arg Glu Val Gly Val Tyr Val
5540 5545 5550
Gly Ala Ala Ala Gln Gly Tyr Gly Leu Gly Ala Glu Asp Thr Glu
5555 5560 5565
Gly Asn Ala Ile Thr Gly Gly Ser Thr Ser Leu Leu Ser Gly Arg
5570 5575 5580
Leu Ala Tyr Val Leu Gly Leu Glu Gly Pro Ser Val Thr Val Asp
5585 5590 5595
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys Gln
5600 5605 5610
Gly Leu Arg Leu Gly Glu Cys Glu Leu Ala Leu Ala Gly Gly Val
5615 5620 5625
Ser Val Leu Ser Ala Thr Cys Cys Ala Ala Phe Val Glu Phe Ser
5630 5635 5640
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly
5645 5650 5655
Ser Gly Ala Asp Gly Thr Thr Trp Ala Glu Gly Val Gly Val Leu
5660 5665 5670
Val Leu Glu Arg Leu Ser Asp Ala Glu Arg Leu Gly His Thr Val
5675 5680 5685
Leu Ser Val Val Arg Gly Ser Ala Val Thr Ser Asp Gly Ala Ser
5690 5695 5700
Asn Gly Leu Thr Ala Pro Asn Gly Leu Ser Gln Gln Arg Ala Ile
5705 5710 5715
Arg Lys Ala Leu Ala Ser Ala Gly Leu Thr Ala Ala Asp Val Asp
5720 5725 5730
Val Val Glu Gly His Gly Thr Gly Thr Arg Leu Gly Asp Pro Val
5735 5740 5745
Glu Ala Asp Ala Leu Leu Ala Thr Tyr Gly Gln Asn Arg Glu Glu
5750 5755 5760
Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Thr
5765 5770 5775
Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Ile
5780 5785 5790
Gly Ala Gly Thr Met Pro Arg Thr Leu His Ala His Glu Pro Ser
5795 5800 5805
Pro Ala Val Asp Trp Ser Ala Gly Gln Val Ser Leu Leu Thr Glu
5810 5815 5820
Asn Arg Pro Trp Pro Asp Gly Glu Arg Pro Arg Arg Ala Ala Val
5825 5830 5835
Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Val Ile Leu Glu
5840 5845 5850
Gln His Arg Pro Ala Pro Val Ala Pro Arg Pro Pro Arg Glu Glu
5855 5860 5865
Pro Arg Pro Leu Pro Trp Val Leu Ser Ala Arg Thr Pro Ala Ala
5870 5875 5880
Leu Arg Ala Arg Ala Ala Gly Leu Arg Asp His Leu Val Thr Ala
5885 5890 5895
Gly Asp Ala Asp Pro Leu Asp Ile Gly Tyr Ala Leu Ala Thr Ser
5900 5905 5910
Arg Ala Pro Phe Ala His Arg Ala Ser Val Val Ala Ser Asp Leu
5915 5920 5925
Asp Gly Phe Arg Ala Ala Leu Asp Gly Val Ala Glu Gly Ser Glu
5930 5935 5940
Ala Pro Gly Val Val Ile Ala Thr Ala Arg Glu Arg Arg Val Ala
5945 5950 5955
Phe Leu Phe Asp Gly Gln Gly Ala Gln Arg Val Gly Met Gly Arg
5960 5965 5970
Glu Leu His Arg Arg Phe Pro Val Phe Ala Glu Ala Trp Asp Glu
5975 5980 5985
Val Ser Asp Ala Phe Gly Thr Tyr Val Glu His Ser Pro Thr Asp
5990 5995 6000
Val Phe His Gly Glu His Gly Asp Leu Ala His Asp Thr Leu Tyr
6005 6010 6015
Ala Gln Ala Gly Leu Phe Thr Leu Glu Ala Ala Leu Leu Arg Leu
6020 6025 6030
Leu Asp His Trp Gly Val Arg Pro Asp Val Val Val Gly His Ser
6035 6040 6045
Val Gly Glu Val Thr Ala Ala Trp Ala Ala Gly Val Leu Thr Leu
6050 6055 6060
Ala Asp Ala Thr Ala Leu Ile Val Ala Arg Gly Arg Ala Leu Arg
6065 6070 6075
Ala Leu Pro Pro Gly Ala Met Thr Ser Val Glu Gly Ser Ala Ala
6080 6085 6090
Glu Val Ala Ala Phe Thr Asp Leu Asp Ile Ala Ala Val Asn Gly
6095 6100 6105
Pro Ser Ala Val Val Leu Thr Gly Ser Pro Asp Asp Val Ala Ala
6110 6115 6120
Phe Glu Gly Glu Trp Ala Ala Ala Gly Arg Arg Ala Arg Arg Leu
6125 6130 6135
Asp Val Gly His Ala Phe His Ser Arg Gln Val Asp Gly Ala Leu
6140 6145 6150
Asp Glu Phe Arg Thr Val Leu Glu Ser Leu Ser Phe Gly Ala Ala
6155 6160 6165
Arg Leu Pro Val Val Ser Thr Thr Thr Gly Arg Glu Ala Ala Gly
6170 6175 6180
Asp Leu Arg Thr Pro Glu His Trp Leu Arg His Thr Arg Arg Pro
6185 6190 6195
Val Leu Phe Ala Asp Ala Val Gly Gln Leu Ala Glu Leu Gly Val
6200 6205 6210
Asn Ala Phe Val Ala Val Gly Pro Ser Gly Ala Leu Ala Ser Ala
6215 6220 6225
Ala Ser Glu Asn Thr Gly Gly Glu Ala Gly Thr Tyr His Ala Val
6230 6235 6240
Leu Arg Gly Arg Val Gly Glu Glu Thr Ser Val Leu Thr Ala Val
6245 6250 6255
Ala Glu Leu His Ala His Gly Ala Pro Val Asp Leu Ala Ala Val
6260 6265 6270
Leu Ala Gly Gly Arg Pro Val Asp Leu Pro Val Tyr Pro Phe Gln
6275 6280 6285
His Arg Ser Tyr Trp Leu Ala Pro Val Thr Gly Gly Ser Ala Pro
6290 6295 6300
Thr Ala Ala Val Gly Thr Gly Pro Leu Ala Glu Pro Glu Pro Asp
6305 6310 6315
Asp Leu Thr Val Ala Glu Ile Val Arg Arg Arg Ala Ala Thr Leu
6320 6325 6330
Leu Gly Val Thr Asp Pro Ala Asp Ile Asp Ala Asp Ala Thr Phe
6335 6340 6345
Phe Ala Leu Gly Phe Asp Ser Leu Ala Val Gln Arg Leu Arg Asn
6350 6355 6360
Gln Leu Thr Ala Ala Thr Gly Leu Asp Leu Pro Thr Ala Val Leu
6365 6370 6375
Phe Asp His Asp Thr Pro Ala Ala Leu Ile Asp Tyr Leu Glu Asp
6380 6385 6390
Gln Leu Gly Glu Asp Glu Asp Ala Asp Asp Asp Glu Pro Thr Val
6395 6400 6405
Leu Ala Leu Leu Ala Asp Met Glu Ser Leu Asp Pro Ala Asp Ile
6410 6415 6420
Ala Ala Thr Pro Ala Ser Glu Arg Ala Ala Ile Ala Asp Leu Leu
6425 6430 6435
Asp Lys Leu Ser Arg Thr Trp Lys Asp His Arg
6440 6445
<210> 123
<211> 19338
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 123
gtgcccgaac aggacaagac ggtcgagtac cttcgctggg cgacctcgga actgcagagg 60
acgcgggcgg aactcgccgc gcgcagcgag cccttggcgg tcgtgggcat ggcctgccgg 120
ctgcccggcg gggtcgcgtc ccccgacgat ctgtggcggc tcctcgactc cgaaggcgac 180
ggcatcggcg ccttccccgc cgaccggggc tgggagaccg gcgccgacgg ccggggcgga 240
ttcctgaccg gggcggccgg gttcgatgcc gcgttcttcg gcgtcagccc gcgtgaggca 300
ctggcgatgg acccgcagca gcgtgtggtc cttgagacgt cctgggaagc gctcgaacac 360
gcgggcatcg acccgcacac gctgagcggc agcgacaccg gagtcttcct cggggcgttc 420
ttccaggggt acggaatcgg cgcggacttc gacgggtacg gcaccacgag catccacacg 480
agcgtgctgt cgggccgcct ctcgtacttc tacggtcttg agggccccgc ggtcaccgtc 540
gacacggcgt gttcgtcgtc gctggtcgcc ctgcaccagg ccgggcagtc cttgcgctcg 600
ggcgaatgct ccctcgccct cgtcggcggg gtcacggtgc tggcgtcgcc cgcgggtttc 660
gcggacttct ccgagcaggg cgggctggcg caggacggcc ggtgcaaggc gttcgccgag 720
gcggcggacg gtaccgcctt cgccgagggc tcgggcgtcc tggtcgtgga acggctctcc 780
gacgcggagc gccggggcca ccggatcctc gcggtcgtac ggggctccgc cgtcaatcag 840
gacggcgcct ccaacgggct ctccgcaccc aacggcccct cccaggaacg cgtcatccgc 900
caggccctcg ccaacgccgg actcaccccc accgacatcc atgccgtcga gggtcacggc 960
acagggaccc gcctcggcga ccccatcgag gcgaccgcgc tgctcgcgac gtacggacag 1020
cagcgcacca cacccctgct cctcggctcc ctcaaatcca atatcggcca cacccaggcc 1080
gccgcgggcg tcgcgggcgt catcaaaatg atcctcgcca tgcaccacgg caccctgccg 1140
cccaccctcc acgtcgacac gccctcctca cacgtcgcct ggacggcggg cgctgtcgaa 1200
ctcctcaccg acgccaggcc ctggcccacc accactggcc cccaccgcgc cggtgtctcc 1260
tccttcggcg tcagcggcac caacgcccac gtcatcatcg aaagccaccc ccaacccgcg 1320
cccgccgccc ccgataccga acccggcgcc cgtcccgtcc ccctgctcct ctcggcccgc 1380
acccccgaag ccctcgacgc gcacaccggc cgccttcgcg cgttcctccg ggacaacccc 1440
ggcgctgacc gtgtcgccat cgcgcagaca ctcgcgcgcc gtaccccgtt cgagcaccgt 1500
gccgtgctgc tcggcgacac gctcatcgcc gctgacccga acgcgggctc gggtccggtc 1560
gtcttcgtct actccgggca gagcaccctc cacccgcaca ccggacgcca actcgccacc 1620
acctaccccg tcttcgcgga cgtgtgggac gaggtcctcg gccatctcga ccccgaccag 1680
gggcctgcca cgcacttcgc ccaccagacc gcgctcaccg cgctgctgcg gtcctggggc 1740
atcaccccgc acgcggtcat cggccactcc ctcggcgaga tcaccgccgc gtgcacggcc 1800
ggtgttctgt ccctcggtga cgcgagcgcg ctcctggccg cccgcagccg cctcatggac 1860
aaactcccca cgggcggcgc catggtcacc gtcctgacga gcgaggagca cgctctgggg 1920
gcgctgcggc ccggggtgga gatcgccgcc gtcaacggcc cgcactccgt cgtactctcc 1980
ggcgacgagg acgccgtgct cgacgtcgcg cggcagctcg gcatccacca ccgcctgccg 2040
acccgccacg cgggccactc cgcacgcatg gaaccgctcg tcgctcccct gctggaagcc 2100
gcgcggaagt tgacgtacca ccagccgcgc gtcgccgtcc ccggtgatcc caccaccgcc 2160
gaatactggg cgcgccaagt ccgtgaccag gtgcggtttc aggcacacac cgagcggtat 2220
ccgggcgcca cgttcctgga gatcgggccc aatcaggatc tctcccccgt catcgacggc 2280
attcccaccc agaccggtgt gcccgacgag gtgcgggcgc tgcacaccgc cctcgcgcac 2340
ctgtacatcc gtggcgtcgc gatcgactgg gcggccgttc tcggcgggga ccgcgcgccc 2400
gtcgcgctgc ccacctaccc gttccagcac aaggactact ggctgcgggc caccgtccgg 2460
gcggatgtga ccggcgcggg gcaggagaag gtggcgcacc cgctgctcgg cgcgtcggtc 2520
gcgctgcccg gttcgggcgg aaccgtactg accggccgtg tctcgctcgc ctcccacccg 2580
tggctcgccg ggcacgctgt caacggcgcc gtgctcctgc cgggtgcggc cttcctcgaa 2640
ctcgcggtgc gcgccggtga cgaggccgga tgcgacctgc tccacgaact cgtcgtcgag 2700
accccgctcg cgttgccggc gacgggcgcc gtggcgatct ccgtggaggt cgccgaggcc 2760
gacgacgcgg ggcggcgggc gctcaccgtg cacgcgcggg tcgaaggcgg gggactgtgg 2820
acccgccacg ccaccggctc cctcggcaag gccgcctcga ccggcgccgc gacggacccg 2880
gctccttggc cgcccgccgg ggccctgccg gtcgaggtcg gcgatgtgta cgagcggttc 2940
gggggcgtcg gctacgcgta cgggccctcg ttccaggggt tgcgggccgc gtggcgcgac 3000
ggagacaccg tccacgccga ggtggcgctg cccgaagagc tgagtgcgga cgccgcccgg 3060
ttcacgctgc atcccgcgct gctcgacgcc gcgttccagg cgggggcgct gcccgcactc 3120
gacgcgcccg gcgaggcggc ccggctgccg ttcgcgttcc aggacgtccg gatcttcgcg 3180
gccggggcga cgcgggcgcg ggtcacggtc ggccgcgaag gggatcgcgg caccgtgacg 3240
atgaccggcg aggacggaca gccggtggcg gtggtgggtt ctgtggtgtc gcgcccgcac 3300
acgggcggta ccggcacggg cacgggctcc gacggtctgc tgcgcccggt atggaccgag 3360
ctgccgatgc ccgctccgtc cgcgagcgac ccgcgcgtgg aggtcttcgg cgcggacccc 3420
gtggacggtg aacccgtgtc ggcgactagg gagttggccg gtcgcgtcct cggcgccctt 3480
cagcggcggc tgtccgccac cgatgacgtg accctggtcg tacgggtcag caccggtctc 3540
gctgcttccg ccgccgcggg cctggtgcgc tccgcgcagg cggagaaccc cggcggtgtc 3600
gtactcgtgg aggcgccccc cgagaccccc accgacctgc tggccgcctg cgccgcgttg 3660
gaagaaccgt ggttggccgt cagggacggt gtgctccacg cgccgcgtct ggtgcggatg 3720
tccgaccccg tgcacggccc actgccgctg ccggacggcg actggctgct cacccgctcc 3780
gcctccggcg ttctgcacga cgtcgcactc accgccgacg gtgcgccccg cagggcactc 3840
gaagccggtg aggtccgcgt cggcgtccgg gccgcgggcc tgaacttccg cgatgtgctg 3900
atcgcgctcg ggacgtacga cggggccacg accatgggcg gcgaggcggc gggcgtcgtc 3960
gtggagaccg ggcccggtgt ggccgacctg tccccgggcg accgggtgtt cggcctgacg 4020
cggggcggca tcgggccgac ggccgtcacc gatcggcgtt ggctggccag gattcccgac 4080
gggtggagct tcaccacggc ggcgtccgtc ccgatcgtct tcgcgaccgc gtggtacggc 4140
ctggtcgacc tggcgggagt acgcgagggc gagaaggtac tcgtgcacgc gggcaccggc 4200
ggtgtgggca tggccgccac gcggatcgcc cgccatctcg gcgccgaggt ctacgccacc 4260
gccggcacgg ggaaacagca cgtgctgcgc gcctcggggc tgcccgacac acacatcgcc 4320
gactcgcgga cgaccgcgtt caggaccgcc ttcccgcgta tggatgtcgt cctgaactca 4380
ctgaccggtg agttcatcga cgcgtctctc gaactcctcg acgcaggcgg ccgattcgtg 4440
gagatgggcc gcgccgagct gcgcgacccg gccacgatca tccccgccta cctgcccttc 4500
gatctcatgg acgcgggcac cgaccgcata ggcgagatcc tgggcgagtt actgacgctc 4560
ttcgacacgg gagccctcag cccgctgccg gtccgcgcct gggacgtccg gcaggcacgt 4620
gaggcgctcg gctggatgag ccgcgcccgt cacatcggca agaacgtcct caccctcccc 4680
cggccgctcg acccggaggg cgcggtcgtc atcacgggcg gctccggcac actcgccggt 4740
atcctcgcgc gtcatttgag cgggctccac gtctacctgc tgtccaggac ggcgccgccc 4800
gaggacacgc cgggcaccca tctgtcctgc gacgtcggcg accgggccca actggcctcg 4860
gccctgtcgc ggatcgaccg gccgatcaca gccgtggtgc acaccgcggg cgtcctggac 4920
gacgggaccg tcccttccct cacgcccgag cgtctggaca ccgtgctgcg cccgaaggcc 4980
gacggggcct ggcacctgca ccagctcacc gaggaccagg acctcgccgc cttcgtgctc 5040
tactcctcgg ccgcaggcgt gctcggcaac gcgggccagg gcaactatgt cgcggccaac 5100
gcgttcctcg acgcgctcgc cgagctgcgc cacgcggccg gcctgcccgc gctctccatc 5160
ggctgggggc tctgggagga cgcgagtggg ctcaccgccg cactgagcga ggcggacagg 5220
gaccggatgc ggcggagcgg attccgtacg atcaccgcgc cccacggcat gcggctgttc 5280
gaggcggcga ggcgcaccgg tactcccgtg gtggtggcgg ccgagctcga cgacgcgccg 5340
gacgtgccgc tgctgcgtgg gcttcggcgt acgactgtgc ggcgcgccac cgtacgggag 5400
cgttctctcg ccgaccggct cgccgcactg tccgacgacg agcgcgccga cgcgctcctc 5460
gcgctcgtca gggacagcac cgccaccgtc ctcggccacc tgggcgccga ggagatcccc 5520
gggacgacga ccttcaagga actcggcatc gactcgctca ccgcggtcca gctgcgcaac 5580
acgctgacca cggcgaccgg ggtacgcctc aacgccacgg cggtcttcga cttcccgacg 5640
ccacgcgcgc tcgccgtcag gctcggcggt gagctgaccg gtatccacgc gcccgtggcg 5700
gccaggaccg cggccacggc ggtcgcgcac gacgagccac tggcgatcgt gggcatggcc 5760
tgccggctgc ccggcggggt cgcgtccccc gacgatctgt ggcggctcgt cgcgtcgggc 5820
accgacgcca tcacggagtt ccccaccgac cggggctggg acgtggacgc gctctacgac 5880
cccgaccccg acgcgatcgg caagaccttc gtcaaacacg gcggcttcct cgacggcgcg 5940
accggcttcg acgcgtcgtt cttcgggatc agcccgcgcg aggccctggc catggacccg 6000
cagcagcggg tgctcctcga aacgtcgtgg gaggcgttcg aaagcgccgg gatcaccccg 6060
gagtcggcca ggggcagcga caccggcgtg ttcatcggcg cgttctcgta cgggtacggc 6120
gcgggcgcgg acaccaacgg tttcggcgcg accggctcgc agaccagcgt cctctccggc 6180
aggctctcct acttctacgg cctggagggg ccgtcggtca cggtcgacac ggcgtgctcg 6240
tcgtcgctgg tcgccctgca ccaggccggg cagtccttgc gctcgggcga atgctccctc 6300
gccctggtcg gcggcgtcac cgtgatggcg tcccccggcg gcttcgtcga gttctcccgt 6360
cagcgcggtc tcgcccccga cgggcgggct aaggcgttcg gcgcgggcgc ggacggtacg 6420
agcttcagcg agggggccgg cgccctgatc gtaaaacggc tctccgacgc ggagcgcgac 6480
gggcacaccg tcctcgctgt cgtacggggc tccgcggtca actccgacgg ggcgtcgaac 6540
ggtctgtcgg cgccgaacgg tcctgcgcag gaacgcgtca tccgccaggc gctcgccaac 6600
gcgggactca ccaccgccga tgtcgacgcg gtcgaggcgc acggcacagg cacccgcctg 6660
ggggacccca tagaggcgca ggcgctgctc gcgacgtacg ggcaggaccg ggcgacgccc 6720
ctgctgctcg gctcgctgaa gtcgaacatc gggcacgccc aggccgcgtc aggtgtcgcg 6780
gggatcatca agacggtgca ggccatccgg cacggggaac tgccgccgac cctgcacgcg 6840
gacgaaccgt caccgcacgt cgactggacg tccggcgccg tcgaactgct gacatcggcc 6900
aggccgtggc cgcggaccgg ccgtccgcgc cgtgcggcgg tctcgtcgtt cggggtgagc 6960
ggcaccaacg cccacatcat cctggaggcc ggacccgacc aggaggagcc gtcggcagaa 7020
ccggccggtg acctcccgct gctcgtgtcg gcacggtccc cggaggcact ggacgagcag 7080
atcgggcgcc tgcgcgacta tctcgacgcc gcccccggcg tggacctggc ggccgtggcg 7140
cggacactgg ccacgcgtac gcacttctcc caccgcgccg tactgctcgg tgacaccgtc 7200
atcaccgctc cccccgtgga acagccgggc gagctcgtct tcgtctactc gggacagggc 7260
acccagcatc ccgcgatggg tgagcggctc gccgcagcct tccccgtgtt cgccgagacc 7320
tggcacgacg cgctgcgccg gctcggcgac cccgacccgc acgaccccac acacagccag 7380
cacacgctct tcgcccatca ggcggcgttc accgccctcc tgcggtcctg ggccgtcacg 7440
ccggacgccg tcatcggaca ctcgctcggc gagatcaccg ccgcgtacgc cgcgggcgtc 7500
ctgtcgctcg gcgacgcctg caccctcgtc accacgcgcg cccgcctcat gcacacgctc 7560
ccgccgcccg gagccatggt caccgtgctg accagcgagg acgaggcccg tcacgccctg 7620
cggaccggcg tggagatcgc cgcggtcaac ggcccccact ccgtggtgct ctccggcgac 7680
gaggacgccg tactcgccgt cgcacagggg ctcggcatcc accaccggct gcccgcgccg 7740
cacgcgggtc actcctcgca catggagccc gtggccgccg agctgctcgc caccacccgc 7800
gggctcactt acggccggcc ccacaccgcc atcccgaacg atccgaccac cgccgagtac 7860
tgggccgagc aggtccgcga gccggtgttg ttccacgccc acgcacagcg gtatcccgac 7920
gccctgttcg tcgagatcgg cccggggcag gacctcgccc cgctggtcga cggcgtcgcc 7980
ctgcagaacg gcacggcgga cgaggtgcac gcgctgcaca ccgcgctcgc ccgcctgtac 8040
acgcgcggcg ccacgctcga ctggccccgc atcctcggcg gcacggcacg gcacgacccg 8100
gacgtacccg cctacgcctt ccagcggcgg ccctactgga tcgagtccgc gccgccggtc 8160
acggccgacg cgggccaccc cgtactgggc acagggatca ccctcgccgg gtcgccgggc 8220
caggtcttca cgggccccgt gccggccggc gccgaccgtg cggtgttcgt cgccgaactg 8280
gccctcgccg ccgcggacgc caccaggtgt gccacggtcg aacggctcga catcgcctcc 8340
gtgccccgcc cgtccgtcgg tggcggggtc accgcgcaaa tctgggtgga tgacccctcg 8400
gccgacgggc ggcgccgctt caccgtgcac acccgcaccg gcgacgcccc gtggacgccg 8460
cacgccgaag gagtcctccg ccccggcgag gtgcccctgc ccgaggccgt cgacaccgcg 8520
tggccaccgc cgggcgcggt gcccgccgac ggggcgcccg gcgcgtggcg ccgcggcgac 8580
caggtcttcg tcgaggccga agtggacagc cccgacggtt tcgtggccca ccccgacctg 8640
ctcgacgcgg tcctctccgc ggtgggcagc ggaagccgcc agccgacccg atggcgcgac 8700
ctggcggtgc acgcgtcgga cgccaccgtg ctgcgcgccc gcctcacccg ccgcgcgggc 8760
ggtgccgtcg aactcgccgc cttcgacggt gcgggtctgc cggtactcac cgcggaggcg 8820
gtgacgttgg gcgaggtcgc gtcggcaggc gaatccgcgc ggtcggacgg tctgctccgg 8880
atcgagtggg tgccgttggc ggaggccgac tacgacggcg acctccccga caactacacc 8940
ctcatcaccg ccgcacaccc cgacgacccc accgacccga acaacacacc cacccgcacc 9000
cacacccaga ccacccgcgt cctcaccgcc ctccaacacc acctcaccac cacccaccac 9060
accctcatcg tccacaccac caccgacccc gcaggcgccg ccgtcaccgg cctcacccgc 9120
accgcccaga acgaacaccc cggccgcatc cacctcatcg aaacacccca cccccacacc 9180
ccactccccc tcaaccaact caccaccctc aaccaacccc acctacgcct cacccaccac 9240
accctccaca caccccacct cacccccctc cccaccacca cccaccacac cccacccctc 9300
aacccccacc acgccatcct catcaccggc ggctccggca ccctcgccgg catcctcgcc 9360
cgccacctca accaccccca cacctacctc ctctcccgca ccccaccacc acacaccacc 9420
cccggcaccc acatcccctg cgacatcacc gaccccaccc aactcaccac cgccctccac 9480
cacatacccc aacccctcac cggcatcttc cacaccgcag gcaccctcaa cgacgccacc 9540
ctcgaccacc aaacccccca ccacctcacc accaccctcc aacccaaagc cgacgccgcc 9600
tggcacctcc accacctcac ccaacaccaa cccctcaccc acttcgtcct ctactccagc 9660
gccgccgcca ccctcggcag ccccggccaa gccaactacg ccgccgccaa cgccttcctc 9720
gacgccctcg ccacccaccg ccacacccac caccaacccg ccaccaccat cgcctggggc 9780
atgtggcaaa ccaccagcac cctcacccaa cacctcacca ccaccgaacg cgaccgcatc 9840
cgccgcggcg gtttcctgcc gatctccgac gaagagggca tgcgtctcta cgacgcggcc 9900
gtcggctcgg gcgaggcttt cgtcatggct gccgcgatgg acctgtcgca gcccatggcg 9960
ggcgatgtac cacccatcct gagtgggctg cgcagaagcg cgcgccgcac cgccagggcg 10020
gggcagacgt tcacgcagcg gctcgccgaa ctgcccgcgg ccgaccgcga cacggcactg 10080
gtcactctcg tctcggatgc cacggccacc gtgctcggcc acgccgacgc ctcagccatc 10140
gcaccgacga cgacgttcaa ggacctcggc atcgactcgc tcaccgcgat cgagctgcgc 10200
aaccggctcg cggaggcgac cgggctccgg ctgagcgcca cgatggtgtt cgaccatccg 10260
acaccgcggg tactcgccgc cgaactgcgc accgacctgt tcggcacggc cgtgcccctg 10320
cccgcccgga cgacacgggc ccgcgacgac gaacccctcg cgatcgtcgg catggcgtgc 10380
cgcctgccgg gcggcgtgac gtcacccgag gaactgtggc ggctcgtcga gtcaggcacg 10440
gacgcgatca ccgagttccc cgacgaccga ggctgggaca tcgaccggat gttcgacccg 10500
gatccggacg caccaggcaa gacctacgtc aggcacggcg gtttcctctc cgaggcagcc 10560
gggttcgacg ccgcgttctt cggcatcagc ccgcgcgagg cgtgggccat ggacccgcag 10620
cagcgcgtca tcctcgaaac cgtctgggag gcgttcgaga acgccggaat cgtccctgac 10680
acgctgcgcg ggagcgacac cggcgtgttc atgggcgcgt tctcccacgg atacggagcc 10740
ggtgtcgacc tcggcgggtt cggcgccacg gccacccaga acagcgtgct ctccggccgc 10800
ctctcgtact tcttcggcat ggaaggccct gccgtcacca tcgacacggc ctgctcgtcg 10860
tccatggtcg ccctgcacca ggcggctcag tccctgcggg acggcgaatg ctcgctggca 10920
ctcgccggcg gcgtcacagt gatgcccaca ccgctggggt acgtcgagtt ctgccgccaa 10980
cgcggactcg cccccgacgg ccgggccaag gccttcgctg agggcgccga cggtacgagt 11040
ttctccgaag gctccggcgt actcgtcgtg gaacggctct ccgacgccga acgcaacggt 11100
cacaccgttc tcgcactcgt ccgctcctcc gccgtcaacc aggacggcgc gtccaacggc 11160
atttccgcgc ccaacggccc ctcacagcag cgcgtgatcc gccaggcgct cgacaaggcg 11220
ggtctcaccc ccgccgacat cgacgtggtg gaggcacacg gcaccggcac cccgctcggc 11280
gacccgatcg aggcgcaggc catcatcgcc acctacggcc aggaccgcga cacaccgctc 11340
tacctcggtt cggtcaagtc gaacatcggc cacacccaga ccaccgccgg tctcgcgggt 11400
gtcatcaaaa tggtcatggc gatgcggcac ggggtgctcc cgaagacgtt gcatgtggat 11460
gagccgtcgt cgcatgtgga ctggtcggcg ggggcggttg agctgttgac ggaggcgagg 11520
ccgtggccgg ggtcggggcg tccgcgccgc gcgggggtgt catcgctcgg catcagtggc 11580
acgaacgcgc atgtgattct ggaaggggtg gaggggccgc cttccggttt ggggccttcc 11640
tcacccactg gggcctcctc tggtgcggag ccgtccgctg gtgcggagtc gtcgggtctg 11700
ggggcgggat cgcccggtgc gggcgcagac gcggacaggg gtttgggtcc ggtgccgttg 11760
ccggtgtctg ctcgtacgga atcgagtctg gcgtcgctgg tggagcggct ggatgcgtat 11820
gtgcggggcg ggttgtccgt gggtggggac ctcggtgggg tggcggatgg tctggtgcgg 11880
gggcgtgcgg tgttcggtca ccgtgcggtg ctgctggggg agagccgtgt cgccggggtg 11940
gcggtggacg ggttgcggac ggtgttcgtg tttccggggc agggttcgca gtggacgggt 12000
atgggtgtgg agttgatgtc cgcctcggag gtgttcgcgg cccggatggc cgagtgcgcg 12060
gcggctttgg agccgttcac gggctgggac gtgcgggaca tgctggcgga ctcggccgtg 12120
ttggagcggg tggaggtgtt gcagccggcg tcgtgggcgg tggcggtgag cctggccgcg 12180
ctgtggcggg cgcacggggt ggtgccggat gcggtggtgg ggcattcgca gggagagatc 12240
gccgccgcct gcgtggcggg ggccctcacc ctggaggacg gggcacggat cgtggcccgc 12300
cgcagccgga gcatcgccgc ccgtctcgcc ggtcacggtg cgatggcgtc catcgccctc 12360
agcgcctcgg aggtcgagac ccccgagggg gtgtggatcg cggcccgtaa tgggcccgcc 12420
tccactgtga tcgcggggga gccggaggcg gtggagcagg ttctggcccg gtacgagcat 12480
gacggggtgc gggtgcggcg gatcgcggtg gactatgcct cgcacactcc gcacgtggag 12540
gcgatcgagg acgaactcgc cgaggccctg gaggggatca ccagtcgggc cccgacggtc 12600
ccgtggtggt cgaccctcga cagcggctgg atcagtgaac ccgtcgagga cggttactgg 12660
tatcgcaatc tgcgctggcc ggtggcgatg gacaccgccg tcagggaact ggacggttcc 12720
ctgttcctcg aatgcagtgc ccacccggtc ctgctgcccg ccctcgacca gccgcacacc 12780
gtcgcgtccc tgcgtaccgg ggacggcggc catccccgct tcgtcaccgc cctggccgag 12840
gcctggaccc agggcgcacc cgtcgactgg accaccctca tcacccccgt cactcccacg 12900
gcccggctgc tggacctgcc cacctacccc ttcgaccaca agcgttactg gatcgaggcc 12960
accaccaccc ccgacctcac cgccctcggc ctcaccgaca ccgcccaccc catgctggcc 13020
gccaccaccg cactgcccac caccgacggc accgtcctca ccggccgcat ctccctacgc 13080
acccacccct ggctcgccga ccacaccatc caggacaccg tcctgctccc cggcaccgcc 13140
ttcctcgaac tcgccgtacg cgccggagac gaaaccggct gcgacaccat cgacgaactc 13200
gtcatcgaaa cccccctcac cctccccgcc accaccgccg tcgacctcac cctcaccatc 13260
gacccacccg acaccacagg acaccacccc ctcaccatcc acgcacgccc cgaaggaacc 13320
cacacctgga cccgccacgc caccggcacc ctcaccaaca caaccaccga cccccacgcc 13380
ccagccacca cggacgtccc cgccggcctg gacgtcccgg acccggacac cttccgccac 13440
tggccgccaa ccggcgccac cgccatggac atcacggagt tctatccgcg gctttccgcg 13500
ctgggctacc ggttcggtcc cacgttccga gggctgcggg cggcctggcg tgacggtgac 13560
accgtctacg ccgaggtggc gctccccgag gaccgtgccg ccgacgccga ccgctacggc 13620
gtacacccgg ccctgctcga cgcggcccta cagagcggca gcctgctcat ggagaagggg 13680
gaaggcgagc agggcgtgca actgccgttc tcctggcacg gcgtccgctt ccacgcgatc 13740
ggggcgacct cgctgcgggt ggcgatcgtg cccggccctg atggcctccg gctccgtgcg 13800
gcggacagcg agaaccaccc cgtcgtgacc atcgacgcgc tggtcacccg gcccccggcc 13860
gatctcgcgc ccgctgagcc cgtgctgcgg gtcgggtggg ccgcggtgcc cgtacccgcc 13920
gaggtccacc cgtcggacgc ggacgtgctg acgctgcaca gcgacgacgc cgacccggtc 13980
caggagacca ggcagctcac cactcgggcg ctcgacgcgc tgctcctggc cgagcggacc 14040
ctgatcgtcc aggccaccgg tggtctcgcc acgatggcgg ccgcgggact ggtccgcacg 14100
gctcagaacg agcagcccgg ccgtttcttc ctggtcgaga cggacgccgg agtggtcctg 14160
gacagttcgc ggcgtgacct gatcgtggcg ctcggagagc ctcggctgcg gctgcgcggc 14220
gaccgtttcg aggcagccag gctgatgcgg gccgcaccgg cgctgacgcc tccggccact 14280
gggtcgtggc agttgcggca ctccgccacc ggctcgctgg acgatctcgc cctcgtcccc 14340
accgacgggc ccgaccgacc gctcgcagcc ggcgaggtgc ggatcgcggt acgcgcggcg 14400
gggctgaact tccgcgatgt caccgtcgcc ctcggcgtcg tcgccgatac ccgcccactc 14460
ggcagcgagg ccgccggggt cgtcctggag accggccccg gcgtgcacga cctggcgccg 14520
ggcgatcggg tccttggaat gctcgccggc gcgttcgggc cggtcgcgat cgctgatcgg 14580
cggttgctgg gccggatgcc ggacgggtgg acgtatccgc aggcggcgtc ggtggtgacc 14640
gtgttcgcga ccgcctggta cggcctggtg gacctggcga agctgcgccc cggcgagaag 14700
atcctcatcc acgcggcggc gaccggggtc ggcgcggcgg ccgtacagat cgcccgccac 14760
ctcggcgccg acatctacgc caccgccggc gcacccaagc agcacctcgt ggacctggac 14820
gacgccaccc acctcgccga ctcccgcacc cccgagatga ccgccacctt ccccccggtc 14880
gacgtcgtac tcaactccct caccggcgac ctcctcgacg cctccgtcgc cctcctcgcc 14940
cccggcggcc ggttcatcga actgggcaag accgacctcc gccacaccgt ccaacaaccc 15000
ttcgacctgg tcgacgcggg ccccgaccgg ctccagcaga tcatcaccga actcctcggc 15060
ctcttcgccg acaacaccct ccacccgcta ccggtccgtg cctgggacgt acgacgggcg 15120
cgggaggcgt tcggattgat gagcagcggc cggcacacgg gcaagtcggt gctgacggtt 15180
ccccggcccc tcgaccccga gggcgccgtc ctcatcaccg gcggctccgg caccctcgcc 15240
ggcatcctcg cccgccacct cgaccacccc cacacctacc tcctctcccg caccccacca 15300
ccggacacca cccccggcac gcacatcccc tgcgacgtca gcgaccccac ccaactcacc 15360
accgccctcc accacatacc ccaacccctc accggcatct tccacaccgc cggcaccctc 15420
gacgacgccc tcctcgacca cctcaccccc caccgcgtcg acaccgtcct taaacccaaa 15480
gccgacgccg cctggcacct ccaccacctc acccaacaca ccgacctcgc cgcattcgtc 15540
ctctactccg cggtcgccgg cgtcatggga agtcctggcc agggcaacta tgtggcggcg 15600
aacgcgttcc tcgacgcgct cgcggaacac cggcagtcca tggggctgcc cgctcagtca 15660
ctggcgtggg gcatgtgggc ggatgtcagc gcgctcaccg cgaaactcac cgccgcggac 15720
cgtgatcgca tccggctcag cgggttcccg ccgttgagcg cggaggacgg catgcggcag 15780
ttcgacgcgg cgaggcgtac gccggagccg gtcgtcgtct cgacgaccgt cgatgtcacc 15840
cggctcgacg ccggccaggt cgcgccgctg ctgcgcggtc tggtggccca caggggcggc 15900
ccgttgcgcg cgtcggcccg taacgccggt gatgagccgt tggcggtccg tctcgccggg 15960
cacaccgtcg ccgagcagcg gcgcgtgatg caggaggtgg tgctccgtca ggcggctgcg 16020
gtgctcgcgt acgggccggg cgaacaggtc gcggccgacc ggccgttccg cgagctcggt 16080
ttcgactcgc tgaccgccgt cgacctgcgt aaccggctcg cggcggagac ggggctgcgg 16140
cttccgacga ccgtggtgtt cagccacccg acagcggact cactcgccac gcatctgctc 16200
gaactgctcg acgctcgcgc cgccgaggcc gtgggggctt ccctgccctc ggtggccgcc 16260
gagcccgcca ccgccgtgcg ggaccaggac gagccgatcg cgatcgtggc gatggcgtgc 16320
cgcctgcccg gcggcgtgac ctcgcccgag gggctgaggc agctcgtcga gtccggtacc 16380
gacgcgatca ccctggtgcc tttggagcgc ggctgggacc tcgacgcgct gtacgacccg 16440
gaccctgacg cggtgggcag ggcgtacagc ctgcggggcg gatttttgga gggtgcggcc 16500
gagttcgacg cggcgttctt cgacatcagt ccgcgggagg cgctcggtat ggatccgcag 16560
cagcgtctgc tgcttgagac ggcctgggag gcaatcgagc gcggccggat caaccccgcg 16620
tcgctgcacg gcagggaggt cggcgtctac gtgggtgccg ccgcgcaggg ctatgggctg 16680
ggcgccgagg acaccgaggg caacgcgatc accggtggct ccacgagtct gctgtccggc 16740
cggctcgcct acgttctcgg gctggagggc ccgtccgtca ccgttgacac ggcgtgctcg 16800
tcgtcgctgg tcgcgctgca cctggcgtgc caggggctgc ggcttggcga gtgcgaactg 16860
gcgctggcgg gcggggtctc cgtgctgagc tcgcctgccg cgttcgtcga gttctcccgt 16920
cagcgcggtc tcgcggccga cgggcgctgc aagtcgttcg gctcgggcgc ggacggcacg 16980
acgtgggccg agggtgtggg tgtcctcgtc ctggagcggc tctccgacgc cgagcggctc 17040
ggccacaccg tgctctccgt cgtccgaggc agcgccgtca cgtccgacgg cgcctccaac 17100
gggctcaccg cgccgaacgg cctctcccag cagcgggcca tccgtaaggc gctcgcctcg 17160
gccgggctga ccgccgccga cgtggacgtc gtggaggggc acggcaccgg caccaggctc 17220
ggcgaccccg tcgaggcgga cgccctgctc gcgacgtacg ggcagaaccg cgaggagccg 17280
gtctggctgg gttcgctgaa gtcgaacatc gggcatgcga cggccgcggc cggggtcgcg 17340
ggggtcatca agatggtgca ggcgatcggg gcgggcacga tgccgaggac gctgcacgcg 17400
cacgagccct cgcccgccgt cgactggagc gcggggcagg tgtccctgct caccgagaac 17460
cggccctggc ctgacgggga gcgtccgcgg cgggcggccg tctccgcgtt cgggttgagt 17520
gggaccaacg cgcacgtcat cctcgaacag caccgtcccg cgcccgtcgc gccccggccg 17580
ccgcgcgagg agccccggcc gctgccgtgg gtgctgtcgg cgcggacgcc ggcggcgctg 17640
cgggcgcggg ccgccgggct ccgcgatcac ctggtgacgg cgggggacgc ggacccgttg 17700
gacatcggat acgcgctggc caccagtcgc gcaccgttcg cgcaccgtgc ctcggtcgtg 17760
gcctccgacc tcgacgggtt ccgcgccgcg ctcgacggcg tcgcggaggg ctcggaggcg 17820
ccgggggtcg tcatcgcaac cgccagggag cggcgtgtgg ccttcctctt cgacggtcag 17880
ggcgcccagc gtgtcggcat gggacgcgaa ctccaccggc gtttccccgt attcgccgag 17940
gcgtgggacg aggtgtcgga cgcattcggc acgtatgtgg agcactcccc cacggatgtc 18000
ttccacggcg agcacggtga tctcgcccat gacaccttgt acgcccaggc cggcctgttc 18060
acgctcgaag cggcgctgct gcggctcctc gatcactggg gtgtgcggcc cgacgtggtc 18120
gtcgggcact ccgtcggtga ggtgacagcg gcctgggcgg cgggggtgct gacactggcg 18180
gacgcgacgg cgttgatcgt ggcccgtgga cgggcgttgc gggcgctgcc gcccggggcg 18240
atgacctcgg tcgagggaag cgcggcggag gtcgccgcgt tcacggatct ggacatcgcc 18300
gcggtcaacg gcccgtccgc cgtggtgctc accggctcac cggacgatgt ggccgcgttc 18360
gaaggggagt gggcggcggc cgggcggcgc gcgaggcggc tcgatgtcgg gcacgcgttc 18420
cactcccggc aggtcgacgg cgccctcgac gagttccgta cggtcctcga atcgctctcg 18480
ttcggcgcgg cgcggctccc tgtggtgtcc acgaccacgg gccgtgaggc ggcgggcgat 18540
ctccggacgc cggagcactg gctgcggcac acccgccgcc cggtgctgtt cgcggacgcc 18600
gtcgggcaac tcgcggagct gggggtgaac gcgttcgtgg ccgtcggccc ttccggggcg 18660
ctggcgtcgg ccgcgtcgga gaacaccggt ggggaagccg ggacgtacca cgcggtgctg 18720
cgcggccggg tgggcgagga gacctcggtg ctgaccgccg tcgccgaact gcatgcccac 18780
ggcgccccgg tcgacctcgc cgctgtgctg gcgggcggac gccccgtgga ccttcccgtc 18840
tacccgttcc agcaccgctc gtactggctg gcccctgtca cgggaggcag tgcaccgacg 18900
gccgcggtgg ggaccggacc actcgctgag cccgagccgg acgacctcac cgtcgccgag 18960
atcgtccggc ggcgcgccgc gacgctgctc ggcgtcacgg accccgccga catcgacgcg 19020
gacgcgacgt tcttcgcgct cggtttcgac tcgctggcgg tccagcggct gcgcaatcag 19080
ctcaccgccg cgaccggcct cgatctgccg acggccgtcc tgttcgacca cgacaccccg 19140
gccgccctca tcgattatct ggaggaccag ctgggtgagg acgaggacgc ggacgacgac 19200
gaacccaccg tcctcgcgct cctggcggat atggagtcgc tcgaccccgc tgacatcgcg 19260
gcgacgccgg cctcggagcg tgcggccatc gccgacctgc tcgacaagct ctcccgtacc 19320
tggaaggacc accgatga 19338
<210> 124
<211> 388
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 124
Met Ser Thr Asp Thr Pro Ala Gly Thr Pro Gln Ala Gly Arg Cys Pro
1 5 10 15
Phe Ala Ile Gln Asp Ala His Arg Ala Ile Leu Asp Ser Ala Thr Val
20 25 30
Gly Ser Phe Asp Leu Phe Gly Ile Lys His Trp Leu Val Ala Ala Ala
35 40 45
Glu Asp Val Lys Leu Val Thr Asn Asp Pro Arg Phe Ser Ser Ala Ala
50 55 60
Pro Ser Glu Met Leu Pro Asp Arg Arg Pro Gly Trp Phe Ser Gly Met
65 70 75 80
Asp Val Pro Glu His Ser Arg Tyr Arg Gln Lys Ile Ala Gly Asp Phe
85 90 95
Thr Leu Arg Ala Ala Arg Arg Gln Glu Glu Phe Val Phe Glu Ala Ala
100 105 110
Asp Ala Cys Leu Asp Glu Ile Glu Ala Ala Gly Pro Gly Ala Asp Leu
115 120 125
Val Pro Gly Tyr Ala Lys Arg Leu Pro Ser Leu Val Ile Asn Ala Leu
130 135 140
Tyr Gly Leu Thr Pro Glu Glu Gly Ala Val Leu Glu Thr Arg Met Arg
145 150 155 160
Gly Ile Thr Gly Ser Thr Asp Leu Asp Ser Val Lys Thr Leu Thr Asp
165 170 175
Asp Phe Phe Ala His Ala Leu Glu Leu Val Arg Ala Lys Arg Asp Glu
180 185 190
Arg Gly Asp Asp Leu Leu His Arg Leu Ala Ser Ala Glu Asp Gly Glu
195 200 205
Ile Pro Leu Ser Asp Asp Glu Ala Thr Gly Val Phe Ala Thr Leu Leu
210 215 220
Phe Ala Gly His Asp Ser Val Gln Gln Met Val Gly Tyr Cys Leu Tyr
225 230 235 240
Ala Leu Leu Ser His Pro Glu Gln Glu Gly Ala Leu Arg Thr Arg Pro
245 250 255
Glu Leu Ile Asp Gly Ala Val Glu Glu Met Leu Arg Phe Leu Pro Val
260 265 270
Asn Gln Met Gly Val Pro Arg Val Cys Val Ala Asp Val Asp Leu Arg
275 280 285
Gly Val Arg Ile Ser Val Gly Asp Asn Val Ile Pro Leu Tyr Ser Thr
290 295 300
Ala Asn Arg Asp Pro Glu Val Phe Pro Asp Pro Asp Thr Phe Asp Val
305 310 315 320
Ser Arg Pro Thr Glu Gly Asn Phe Ala Phe Gly His Gly Val His Lys
325 330 335
Cys Pro Gly Gln His Val Ala Arg Leu Leu Ile Lys Val Ala Cys Leu
340 345 350
Arg Leu Leu Glu Arg Phe Pro Asp Val Arg Leu Val Gly Asp Val Pro
355 360 365
Met Asn Glu Gly Leu Gly Leu Phe Ser Pro Ala Glu Leu Arg Ile Thr
370 375 380
Trp Gly Ala Ala
385
<210> 125
<211> 1167
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 125
atgagcaccg acacacccgc cgggacgccg caggccgggc gctgcccgtt cgcgatccag 60
gacgcccatc gggcgatcct ggacagcgcc acggtcggct cgttcgacct gttcggcatc 120
aagcactggc tggtcgccgc cgcagaggac gtcaagctgg tcaccaacga cccccggttc 180
agctcggccg cgccctcgga gatgctgccc gaccggcgtc cgggctggtt ctccggcatg 240
gacgttcccg agcacagccg ctatcggcag aagatcgccg gggacttcac gctgcgcgcc 300
gcgcgcaggc aggaggagtt cgtcttcgag gccgctgacg cctgtctgga cgagatcgag 360
gccgctggtc ccggcgccga cctggttccc gggtacgcga agcggctccc ctcgctcgtc 420
atcaacgcgt tgtacgggct cacccccgag gagggagcgg tacttgagac gcgtatgcgc 480
ggtatcacgg gctcgaccga cctggacagt gtcaaaacgc tgaccgacga cttcttcgcg 540
cacgcgctgg agttggtccg tgccaaacgc gacgagcggg gcgacgatct gctgcaccgg 600
ctggcctcgg ccgaggacgg cgagatcccg ctgagcgacg acgaggcgac gggggtgttc 660
gcgacgctgc tgttcgccgg gcacgactcg gtgcagcaga tggtcggcta ctgcctctac 720
gcactgctca gccaccccga gcaggagggg gcgctgcgca cacgcccgga gctgatcgac 780
ggcgcggtcg aggagatgct gcgtttcctc cccgtcaacc agatgggggt gccgagggtc 840
tgcgtcgccg atgtggatct gcgtggtgtc cggatcagtg tgggagacaa cgtgatcccg 900
ctctattcga cggccaaccg cgacccggag gtgttccccg acccggacac gttcgatgtg 960
agccgcccga cggaggggaa cttcgctttc ggtcacggcg tccacaagtg tcctggccaa 1020
cacgttgccc ggctgctcat caaggtcgcc tgcctgcggc tgctggagcg tttccctgac 1080
gtccgcctcg tcggcgacgt accgatgaac gagggcctcg ggcttttcag cccggccgag 1140
ctgcggatca cctggggtgc ggcgtga 1167
<210> 126
<211> 260
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 126
Val Ser Asp Val Val Glu Thr Leu Arg Leu Pro Asn Gly Ala Thr Val
1 5 10 15
Ala His Val Asn Ala Gly Glu Ala Gln Phe Leu Tyr Arg Glu Ile Phe
20 25 30
Thr Asp Arg Cys Tyr Leu Arg His Gly Val Glu Leu Arg Pro Gly Asp
35 40 45
Val Val Phe Asp Val Gly Ala Asn Ile Gly Met Phe Met Leu Phe Ala
50 55 60
His Leu Glu His Pro Gly Val Thr Val His Ala Phe Glu Pro Ala Pro
65 70 75 80
Val Pro Phe Ala Ala Leu Arg Ala Asn Ala Val Arg His Arg Val Ala
85 90 95
Gly Arg Val Asp Gln Cys Ala Val Ser Asp Glu Ala Gly Val Arg Arg
100 105 110
Met Thr Phe Tyr Pro Asp Ala Thr Leu Met Ser Gly Phe His Pro Asp
115 120 125
Ala Ala Ala Arg Lys Glu Leu Leu Arg Thr Leu Gly Leu Asn Gly Gly
130 135 140
Tyr Thr Ala Glu Asp Val Asp Met Met Leu Ala Gln Leu Pro Asp Thr
145 150 155 160
Gly Glu Glu Ile Glu Thr Ser Val Val Arg Leu Ser Asp Val Ile Ala
165 170 175
Glu Arg Gly Ile Ala Ala Ile Gly Leu Leu Lys Ile Asp Val Glu Lys
180 185 190
Ser Glu Arg Arg Val Leu Ala Gly Val Glu Asp Ala Asp Trp Pro Arg
195 200 205
Ile Arg Gln Val Val Ala Glu Val His Asp Val Asp Gly Ala Leu Gly
210 215 220
Glu Val Val Ala Leu Leu Arg Gly His Gly Phe Thr Val Val Ala Glu
225 230 235 240
Gln Asp Pro Leu Phe Ala Gly Thr Glu Ile His Gln Val Ala Ala Arg
245 250 255
Arg Thr Ala Gly
260
<210> 127
<211> 783
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 127
gtgagtgacg tggtggagac cttgcggctg ccgaacggcg cgacggtcgc gcacgtcaac 60
gcgggcgagg cgcagttcct ttaccgggag atcttcacgg accgctgcta tctgcgccac 120
ggcgtcgaac tgcgcccggg ggacgtggtg ttcgacgtcg gcgccaacat cggcatgttc 180
atgctcttcg cccatctcga acatcccggt gtgaccgtgc acgccttcga acccgcgcct 240
gtgccgttcg ccgcactgcg ggcgaacgcg gtacggcacc gcgtcgccgg ccgggtggac 300
cagtgcgccg tttccgacga ggccggcgta cgcaggatga cgttctaccc cgacgccacg 360
ctgatgtccg gtttccaccc ggacgccgcc gcccgcaagg agctgctgcg caccctcggc 420
ctcaacggcg gctacaccgc tgaggacgtc gacatgatgc tcgcccaact gcccgacacg 480
ggagaggaga tcgaaacctc ggtcgtccgg ctctccgacg tcatcgcgga gcgtggcatc 540
gcggcgatcg gcctcctgaa gatcgacgtg gagaagagcg aacggcgggt cctcgccggc 600
gtcgaggacg ccgactggcc ccgcatccgt caggtcgtcg cggaggtcca cgacgtcgat 660
ggcgcgctcg gtgaggtcgt cgcgctgctg cgcggccatg gcttcaccgt cgtcgccgag 720
caggatccgc tgttcgctgg cacggagatc caccaggtgg ccgcgcggcg tacggccggc 780
tga 783
<210> 128
<211> 934
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 128
Leu Ala Pro Thr Asp Phe Asp Tyr Gly Arg Glu Val Val Pro Glu Val
1 5 10 15
Arg Ala Ala Pro Asp Glu Leu Ile Ala Arg Asp Asp Glu Leu Ser Arg
20 25 30
Leu His Ser Ala Leu Thr Arg Ala Gly Ser Gly Arg Gly Leu Val Val
35 40 45
Ala Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr Ala Leu Leu Asp Ala
50 55 60
Gly Ala Ala Glu Ala Gly Phe Val Thr Leu Arg Ala Val Cys Ser Met
65 70 75 80
Glu Glu Arg Ala Val Pro Tyr Gly Met Leu Gly Gln Leu Phe Asp His
85 90 95
Pro Val Leu Ala Ala Gln Ala Pro Glu Pro Val Arg Leu Thr Ala Ser
100 105 110
Cys Glu Asp Pro Gln Asp Gly Thr Asp Asn Arg Leu Arg Ala Glu Phe
115 120 125
Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Trp Pro Val Leu Ile Gly
130 135 140
Ile Asp Asp Val His His Ala Asp Pro Ala Ser Leu Arg Cys Leu Leu
145 150 155 160
His Leu Val Arg Arg Ile Gly Pro Ala Arg Ile Ala Val Val Leu Thr
165 170 175
Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg Phe Gln Ala Glu Leu
180 185 190
Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu Arg Pro Leu Asn Glu
195 200 205
Ala Gln Thr Thr Glu Leu Val Arg Gly Gln Leu Gly Glu Glu Ala His
210 215 220
Asp Asp Ile Cys Ala Asp Thr Phe Arg Ala Thr Gly Gly Asn Leu Leu
225 230 235 240
Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu Ala Trp Ala Ala Gly
245 250 255
Arg Ser Gly Val Val Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Gly
260 265 270
Ser Leu Tyr Arg Cys Gly Pro Leu Ala Leu Arg Val Ala Arg Ala Ser
275 280 285
Ala Val Leu Ser Ala Ser Thr Glu Pro Val Leu Val Gln Arg Met Thr
290 295 300
Gly Leu Gly Gly Glu Thr Val Glu Gln Val Tyr Glu Gln Leu Asn Glu
305 310 315 320
Gly Arg Leu Leu Gln Gly Asp Arg Phe Pro His Pro Ala Ala Arg Ser
325 330 335
Ile Val Leu Asp Asp Leu Ser Ala Ser Glu Arg Arg Asn Leu His Glu
340 345 350
Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val Ala Gly Asn Val Leu
355 360 365
Ala Arg His Gln Ile Gly Thr Gly Arg Val His Gly Ala Glu Val Val
370 375 380
Ala Leu Phe Thr Glu Ala Ala Arg Glu His His Leu Arg Gly Glu Leu
385 390 395 400
Asp Glu Ala Ala Gly Tyr Leu Glu Leu Ala His Arg Ala Ser Asp Asp
405 410 415
Pro Gly Thr Arg Ala Ala Leu Arg Val Gly Ala Ala Ala Ile Glu Arg
420 425 430
Leu Cys Asn Pro Val Arg Ala Gly Arg His Leu Pro Glu Leu Leu Thr
435 440 445
Ala Ser Arg Ala Gly Leu Leu Ser Pro Glu His Ala Val Ser Leu Ala
450 455 460
Asp Trp Leu Ala Met Gly Gly Arg Pro Asp Glu Ala Ala Glu Val Leu
465 470 475 480
Ala Ala Gln Arg Pro Ala Ala Gly Ser Glu Gln Asn Lys Ala Leu Leu
485 490 495
Arg Val Gly Glu Leu Ser Leu Gly Leu Val His Pro Gly Ala Ser Asp
500 505 510
Pro Ala His Arg Thr Asp Pro Phe Ala Ser Gly Gly Leu Ala Ala Leu
515 520 525
Pro Gly Pro Ala Arg Asn Arg Ala Val Ala Asp Lys Ala Val Ile Ala
530 535 540
Ala Leu Arg Gly Arg Tyr Glu Arg Ala Asp Val His Ala Glu Arg Val
545 550 555 560
Leu Gln His Thr His Ala Thr Ala Asp Arg Thr Thr Ala Met Met Ala
565 570 575
Leu Leu Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ala Val Gln Phe Trp
580 585 590
Val Asp Lys Leu Ala Gly Asp Glu Gly Thr Arg Thr Pro Ala Asp Glu
595 600 605
Ala Val His Ala Gly Phe Asn Ala Glu Thr Ala Leu Arg Arg Gly Asp
610 615 620
Leu Thr Ser Ala Val Glu Tyr Gly Glu Thr Ala Leu Gly Pro Arg His
625 630 635 640
Ala Pro Thr Trp Gly Val Ala Ala Ala Leu Pro Leu Ser Ser Thr Val
645 650 655
Val Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg Ala Glu Arg Trp Leu
660 665 670
Ala Gly Pro Leu Pro Gln Glu Thr Pro Glu Ser Leu Phe Gly Leu His
675 680 685
Leu Leu Trp Ala Arg Gly Gln His His Leu Ala Thr Gly Arg Tyr Arg
690 695 700
Ala Ala His Thr Ala Phe Arg Glu Cys Gly Glu Arg Met Arg Arg Trp
705 710 715 720
Ala Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala Glu
725 730 735
Ser Leu Leu Leu Leu Gly Arg Asp Arg Ala Glu Gly Leu Arg Leu Ile
740 745 750
Ser Glu Gln Leu Ser Arg Pro Met Arg Ala Arg Ala Arg Val Leu Thr
755 760 765
Leu Arg Val Gln Ala Ala Tyr Ser Pro Leu Pro Gln Arg Ile Asp Leu
770 775 780
Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys Asn Asp Arg Tyr Glu
785 790 795 800
Leu Ala His Val Leu Thr Asp Leu Ala Glu Ala Ser Ser Met Val Arg
805 810 815
His His Ser Arg Ala Arg Gly Leu Phe Arg Arg Ala Arg His Leu Ala
820 825 830
Thr Gln Cys Gly Ala Ala Pro Leu Leu Arg Arg Leu Gly Ala Glu Pro
835 840 845
Ser Asp Ile Gly Gly Ala Trp Asn Ala Pro Pro Gly Gln Arg Ile Ala
850 855 860
Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala Leu Ala Ala Ile Gly
865 870 875 880
Arg Thr Asn Arg Glu Ile Ala Asp Gln Leu Phe Val Thr Ala Ser Thr
885 890 895
Val Glu Gln His Leu Thr Asn Val Phe Arg Lys Leu Gly Val Lys Gly
900 905 910
Arg Gln Gln Leu Pro Arg Glu Leu Ala Asp Val Gly Glu Pro Ala Gly
915 920 925
Arg Asp Arg Arg Cys Gly
930
<210> 129
<211> 2805
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 129
ttggcgccga ccgatttcga ctacggccgc gaggtggttc cggaagtgcg agcagccccc 60
gatgaactga tcgcccgcga tgacgagctg agccgcctcc actcggcact caccagggcg 120
gggagtggac ggggcctggt cgtcgccatc acaggaccga tagccagcgg caagacggca 180
ctgctcgacg ccggcgcggc cgaggcgggc ttcgtcaccc tccgggcggt gtgctccatg 240
gaggagcgcg ccgtgcccta tgggatgctc ggccagctct tcgaccatcc cgtgctggcc 300
gcccaggctc cggagccggt ccgcctcacg gcctcgtgcg aggaccccca ggacggtacc 360
gacaaccggc tgcgggccga gttcacccgc acgctgctgg cgctcgccgc ggactggccc 420
gtactgatcg gcatcgacga cgtgcaccac gcggacccgg catcgctgcg ctgcctgctc 480
cacctcgtgc gccgcatcgg cccggcccgt atcgcggtcg tgctgaccga gctgcgcagg 540
ccgaccccgg ccgactcgcg tttccaggcg gaactgctga gcctgcgttc ctaccaggag 600
atcgcgctgc ggccgctcaa cgaggcgcag accaccgaac tcgtacgcgg gcagctcggc 660
gaggaggcgc acgacgacat ctgcgccgac acgttccggg cgaccggcgg aaacctgctc 720
ctcgggcacg gcctgatcaa cgacatcagg gaggcgtggg cggcgggccg ctccggggtg 780
gtcgcggggc gggcgtaccg gctcgcgtac ctgggctcgc tctaccgctg cggcccgctg 840
gcgctgcgtg tcgccagggc ctccgccgtg ctcagcgcga gtacggagcc cgtgctcgtc 900
cagcggatga ccggactggg cggggagacc gtcgaacaag tatacgaaca gttgaacgag 960
gggcggctgt tgcagggcga ccggttcccg cacccggccg cccggtccat cgtccttgac 1020
gacctgtcgg cgtcggaacg ccgcaacctg cacgaatcgg cgctggaact gctgcgggac 1080
cacggcgtgg cgggcaacgt gctcgcccgt caccagatcg gcaccggccg cgtgcacggc 1140
gccgaggtcg tcgcactgtt caccgaggcc gcgcgtgagc atcacctgcg cggcgaactc 1200
gacgaggcgg ccggatacct ggaactcgcc caccgggcct cggacgaccc cggcacgcgc 1260
gccgcactgc gcgtcggcgc cgccgcgatc gaacgcctct gcaacccggt gcgggccggc 1320
cggcacctgc ccgagctgct caccgcgtcc cgcgcggggc tgctctcccc cgagcacgcc 1380
gtgtcgctcg ccgactggct ggcgatgggc gggcgcccgg acgaggcggc cgaggtcctc 1440
gcggcgcagc ggcccgcggc cggcagcgag cagaacaagg cgctcctgcg cgtcggcgag 1500
ttatccctcg gactggtcca ccccggcgcg tcggaccccg cacacaggac cgacccgttc 1560
gcctccggcg gactcgccgc gctgcccgga cccgccagga accgcgccgt cgccgacaag 1620
gccgtcatcg ccgcgctgcg cggccgctac gagcgggccg atgtccacgc cgagcgggtc 1680
ctccagcaca cccacgccac ggcggacagg accacggcca tgatggcgtt gctggcgctg 1740
ctctacgcgg agaacaccga ggccgtccag ttctgggtcg acaaactggc cggcgacgag 1800
ggcacgcgga caccggcgga cgaggcggtc cacgcggggt tcaacgccga gaccgcgctg 1860
cgccgcggcg atctgacctc ggccgtcgag tacggcgaga cggcgctcgg gccccggcac 1920
gcgcccacct ggggggtggc tgccgcgctg ccactgagca gcaccgtggt cgccgcgatc 1980
cggctcggcg acctcgaccg ggccgagcgg tggctcgcgg ggccgctgcc gcaggagacg 2040
ccggagagtc tcttcgggct gcatctgctc tgggcccgcg gacagcacca cctcgctacc 2100
ggccggtacc gggcggccca cacggcgttc agggagtgcg gggagcggat gcggcgctgg 2160
gccgtcgacg tgcctggcct ggcgctctgg cgggtcgacg ccgccgagtc gctgctgctg 2220
ctcggccgtg accgcgccga aggactgcgg ctcatctccg agcagctgtc ccggccgatg 2280
cgggcccgcg cacgggtgct gacgctgcgg gtacaggcgg cctacagccc cttgccccaa 2340
cggatcgacc tgctcgaaga ggccgccgac ctgctcgtca cctgcaacga ccggtacgaa 2400
ctcgcgcacg tcctcaccga cctggccgag gcgtccagca tggtcaggca ccacagccgg 2460
gcacggggcc tgttccgccg ggcacggcac ctcgcgaccc agtgcggtgc cgctccgctt 2520
ctgcgcaggc tcggcgcgga gccctcggac atcggcggcg cctggaacgc gccgccgggg 2580
cagcggatcg cctcactgac ggagtcggaa cgacgggtcg ccgcgctcgc cgcgatcggg 2640
cgcaccaaca gggagatcgc cgaccaactg ttcgtcacgg ccagcaccgt ggaacagcac 2700
ctcaccaacg tattccgcaa actgggggtg aagggccgcc agcagcttcc gagggaactg 2760
gccgatgtcg gtgagcccgc gggccgcgac cgccggtgcg ggtag 2805
<210> 130
<211> 255
<212> PRT
<213> Streptomyces sp. ATCC55098
<400> 130
Met Arg Glu Glu Leu Trp Leu Arg Gln Phe Phe Pro Thr Pro Asp Ala
1 5 10 15
Pro Val Arg Val Val Leu Leu Pro His Ser Gly Gly Ser Ala Thr Phe
20 25 30
Tyr Leu Pro Leu Ala Arg Ala Leu Ala Pro Val Ala Asp Val Tyr Ala
35 40 45
Val Gln Tyr Pro Gly Arg Gln Asp Arg Arg Asp Glu Glu Pro Val Arg
50 55 60
Asp Leu Arg Thr Leu Ala Gly Arg Val Ala Asp Val Leu Lys Pro Gly
65 70 75 80
Leu Asp Arg Pro Leu Val Leu Phe Gly His Ser Met Gly Ala Thr Leu
85 90 95
Ala Phe Glu Leu Ala Gln Arg Leu Pro Val Ala His Leu Ile Val Ser
100 105 110
Gly Gly Arg Ala Pro Ser His Ala Leu Thr Asp Thr Val His Leu Ala
115 120 125
Ser Asp Glu Glu Leu Leu Ala Thr Val Ser Ala Leu Gly Gly Thr Ser
130 135 140
Ala Asp Val Leu Ala Asp Asp Glu Leu Arg Ala Leu Val Leu Pro Pro
145 150 155 160
Leu Arg Ala Asp Tyr Tyr Ala Ala Glu Thr Tyr Arg Trp Glu Thr Ala
165 170 175
Pro Pro Met Asp Thr Pro Val Thr Val Cys Val Gly Asp Ser Asp Pro
180 185 190
Lys Thr Thr Val Glu Gln Ala Arg Ala Trp Ala Gly His Thr Thr Ala
195 200 205
Pro Thr Thr Val Glu Ile Phe Thr Gly Gly His Phe Tyr Leu Val Asp
210 215 220
His Leu Asp Arg Val Ala Glu Leu Val Ala Arg Gly Ala Arg Leu Ala
225 230 235 240
Ala Gln Glu Ala Gly Ala Pro Glu Glu Ala Asp His Ala Thr Arg
245 250 255
<210> 131
<211> 768
<212> DNA
<213> Streptomyces sp. ATCC55098
<400> 131
atgagggaag agctctggtt gcgacagttc ttcccgacgc ccgacgcccc cgtacgggtg 60
gtgctcctgc cccactccgg agggtcggcg accttctacc ttccgctggc tcgcgcgctc 120
gccccggtgg cggacgtgta cgccgtgcag taccccggac gccaggaccg tcgggacgag 180
gaaccggtac gggacctgcg caccctggcc gggcgcgtgg ccgacgtgct gaagccgggt 240
ctcgaccggc cgttggtgct cttcggccac agcatggggg cgacactcgc gttcgagctg 300
gcccagcggc tcccggtggc ccatctgatc gtctcgggcg gccgcgcgcc ctcgcacgcc 360
ctcaccgaca ccgtccacct ggcgtcggac gaggaactgc tggcaacggt gtcagctctc 420
ggcgggacca gcgccgacgt gctggcggat gacgaactgc gcgcgctggt cctgccgcca 480
ctgcgcgcgg actactacgc ggcggagacg taccggtggg agaccgcgcc gccgatggac 540
acgccggtca cggtctgcgt cggcgacagc gatccgaaga cgacggtgga gcaggcccgt 600
gcctgggccg ggcacaccac cgcgccgacg accgtggaga tcttcaccgg cggtcacttc 660
tacctcgtcg atcacctgga ccgggtggcc gagttggtgg cgcgaggcgc gaggctcgcg 720
gcgcaggagg ccggtgcgcc cgaagaagcg gaccatgcca cccgttaa 768
<210> 132
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsA
<400> 132
gaccggcccg ggccatcccg acgaaaggac gatgacatga ttccggggat ccgtcgacc 59
<210> 133
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsA
<400> 133
ccctccccgt ccggagcacg ggagatcacg accggatcat gtaggctgga gctgcttc 58
<210> 134
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsB
<400> 134
gcaccggttc cgtttccggg cggcggtgat ccggtcgtga ttccggggat ccgtcgacc 59
<210> 135
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsB
<400> 135
cgtcggcggg ggagagggtg atcaccgggc ccggttcgct gtaggctgga gctgcttc 58
<210> 136
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsC
<400> 136
gccatcgccg cctgcgaggt cccggccggc taccgggcca ttccggggat ccgtcgacc 59
<210> 137
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsC
<400> 137
ggggtcgcgc actcccatgc cggggcggtc ggcgaggcat gtaggctgga gctgcttc 58
<210> 138
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsD
<400> 138
cgacagcatc aacctgttcc ggaaggggca gccccggtga ttccggggat ccgtcgacc 59
<210> 139
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsD
<400> 139
acccaggccc tgacgcggga ctgaccagaa catgccctat gtaggctgga gctgcttc 58
<210> 140
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for fkbA
<400> 140
cgtacccgtc accggccccg tgggaagcga gtagccgtga ttccggggat ccgtcgacc 59
<210> 141
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for fkbA
<400> 141
gtccggcggg cgtcgtctcg tcgggtgtgt cggtgctcat gtaggctgga gctgcttc 58
<210> 142
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for fkbD
<400> 142
acgacgcccg ccggacgctg cccgttcgcg atccaggaca ttccggggat ccgtcgacc 59
<210> 143
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for fkbD
<400> 143
ggcgaggcgg acgtccggga agcgttcgaa caaccgcagt gtaggctgga gctgcttc 58
<210> 144
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for fkbM
<400> 144
cagcccggcc gaactgcgga tcacctgggg tacggcgtga ttccggggat ccgtcgacc 59
<210> 145
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for fkbM
<400> 145
ccggggcgac cggtgcgggt agccgccccc ggcggctcat gtaggctgga gctgcttc 58
<210> 146
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for fkbN
<400> 146
gaacggcgca gaacccatgg agacgacggc cgcgaggtga ttccggggat ccgtcgacc 59
<210> 147
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for fkbN
<400> 147
cgcacggcgg ccggccggct gagccgccgg gggcggctat gtaggctgga gctgcttc 58
<210> 148
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for fkbQ
<400> 148
gcacggcgtc cccacggtgc ccggggcccg gaccggatga ttccggggat ccgtcgacc 59
<210> 149
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for fkbQ
<400> 149
atgggttctg cgccgttcat ctactggtaa atgcagctat gtaggctgga gctgcttc 58
<210> 150
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs7
<400> 150
tgacggcact tgagccgtcc ggtgatggaa ttctgaatga ttccggggat ccgtcgacc 59
<210> 151
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs7
<400> 151
tatcgcctat gcgctcagcg agggagcggg ggattctcat gtaggctgga gctgcttc 58
<210> 152
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs5
<400> 152
tgaggggggc cgacgatgac gacggcaggc ctccgggtga ttccggggat ccgtcgacc 59
<210> 153
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs5
<400> 153
gggggcggca tcgcgatcgc agggcgcggg gccgcgtcat gtaggctgga gctgcttc 58
<210> 154
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs4
<400> 154
gtaccggggc ggcacgacga aagggcaggg acgactgtga ttccggggat ccgtcgacc 59
<210> 155
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs4
<400> 155
cacccggagg cctgccgtcg tcatcgtcgg cccccctcat gtaggctgga gctgcttc 58
<210> 156
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs3
<400> 156
gtcgttccat ccaccctctg tctccaagga gacctcgtga ttccggggat ccgtcgacc 59
<210> 157
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs3
<400> 157
ctgttgagag cggacatccc tgccgtcggc cgggggctat gtaggctgga gctgcttc 58
<210> 158
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs2
<400> 158
aggatcagtg actgaatctc gcactacatt cggtccatga ttccggggat ccgtcgacc 59
<210> 159
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs2
<400> 159
ccgcccgacc tgccgacgaa tcrccgattc agatcactat gtaggctgga gctgcttc 58
<210> 160
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcs1
<400> 160
agtcactgat cctgacgctt tgcgaagact gtcgtcatga ttccggggat ccgtcgacc 59
<210> 161
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcs1
<400> 161
gtccccaccg cgaaacgtac ctagggcatg ttctggtcat gtaggctgga gctgcttc 58
<210> 162
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsA of S. kanamyceticus KCTC9225
<400> 162
caactcgagc cggtgcagcc tctgttgttc tcgcctgaca ttccggggat ccgtcgacc 59
<210> 163
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsA of S. kanamyceticus KCTC9225
<400> 163
cgtggcatac gttcccgcgg tggcgtcgtg gaccctgtct gtaggctgga gctgcttc 58
<210> 164
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsB of S.kanamyceticus
<400> 164
cgcgcctacg tacgcacctc gggcttcctg cacgacttca ttccggggat ccgtcgacc 59
<210> 165
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsB of S. kanamyceticus
<400> 165
ggcgagcggg ttcaggccgt gggcgcgggc gaccgagtct gtaggctgga gctgcttc 58
<210> 166
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsC of S.kanamyceticus
<400> 166
gtcgtcctcg cggcggacca gcaggctctc gcgggaacga ttccggggat ccgtcgacc 59
<210> 167
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsC of S. kanamyceticus
<400> 167
ggcgtgggtg gcgtcgccga cggcgtcgag gggataggct gtaggctgga gctgcttc 58
<210> 168
<211> 59
<212> DNA
<213> artificial
<220>
<223> primer for tcsD of S. kanamyceticus
<400> 168
ctggcgttgt acgagcggtt cgcggagacg ggcctgatga ttccggggat ccgtcgacc 59
<210> 169
<211> 58
<212> DNA
<213> artificial
<220>
<223> primer for tcsD of S.kanamyceticus
<400> 169
cgaggcgtgc cggacgtccc gcagcagctt gccgatcggt gtaggctgga gctgcttc 58
Claims (11)
- 서열번호 1, 54 또는 93의 서열 또는 상기 서열에 상보적인 서열로 표시되는 타크롤리무스 생합성 유전자 클러스터
- 서열번호 3, 56 또는 95의 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자
- 서열번호 2, 55 또는 94의 서열로 표시되는 폴리케타이드 합성효소
- 서열번호 5, 58 또는 97의 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자
- 서열번호 4, 57 또는 96의 서열로 표시되는 폴리케타이드 합성효소
- 서열번호 7, 60 또는 99의 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자
- 서열번호 6, 59 또는 98의 서열로 표시되는 폴리케타이드 합성효소
- 서열번호 9, 62 또는 101의 서열 또는 상기 서열에 상보적인 서열로 표시되는 폴리케타이드 합성효소 유전자
- 서열번호 8, 61 또는 100의 서열로 표시되는 폴리케타이드 합성효소
- 삭제
- 삭제
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PCT/KR2010/008496 WO2011068341A2 (ko) | 2009-12-03 | 2010-11-29 | 삼원환 화합물의 생합성을 담당하는 유전자와 단백질 |
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WO2020122611A1 (ko) | 2018-12-11 | 2020-06-18 | 이화여자대학교 산학협력단 | 신규 화합물 및 이를 포함하는 발모 촉진용 조성물 |
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DE69934242T2 (de) * | 1998-10-02 | 2007-09-20 | Kosan Biosciences, Inc., Hayward | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen |
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Non-Patent Citations (3)
Title |
---|
논문1: J BACTERIOL.* |
논문2: GENE. |
염기서열(2010) |
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KR20110062208A (ko) | 2011-06-10 |
WO2011068341A3 (ko) | 2011-12-22 |
WO2011068341A2 (ko) | 2011-06-09 |
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