CN111607603B - Hangtaimycin生物合成基因簇及其应用 - Google Patents

Hangtaimycin生物合成基因簇及其应用 Download PDF

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CN111607603B
CN111607603B CN202010426408.0A CN202010426408A CN111607603B CN 111607603 B CN111607603 B CN 111607603B CN 202010426408 A CN202010426408 A CN 202010426408A CN 111607603 B CN111607603 B CN 111607603B
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hangtaimycin
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孙宇辉
罗明和
邓子新
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Abstract

本发明公开了一种Hangtaimycin生物合成基因簇及其应用。其核苷酸序列如SEQ ID NO.1的第1‑91594位所示，包含21个基因。本发明所提供的hangtaimycin生物合成簇所有基因和蛋白信息，有助于人们理解hangtaimycin家族天然产物的生物合成机制，以及在此基础上为通过遗传改造产生可用于医药、工业或农业的hangtaimycin新结构衍生物提供了材料和认识，本发明所提供的基因及其蛋白信息还可以用于发现同类化合物、基因或蛋白。

Description

Hangtaimycin生物合成基因簇及其应用
技术领域
本发明属于微生物基因工程领域，具体涉及一种Hangtaimycin生物合成基因簇及其应用。
背景技术
Hangtaimycin是一个具有独特δ不饱和六元环内酯以及末端环二肽单元的新颖聚酮聚肽类杂合化合物(图1)。虽然hangtaimycin最初于2016年从链霉菌Streptomycesspectabilis CPCC200148中分离获得，却只进行了初步的抗肿瘤及抗白色念珠菌的活性测试。我们在对链霉菌Streptomyces spectabilis CCTCC M2017417的活性次生代谢产物研究中分离鉴定出hangtaimycin，并对hangtaimycin及其衍生物进行了更广泛的生物活性考察和生物合成机制研究。
生物学活性测试结果显示，hangtaimycin的甲醇水解产物hangtaimycinA具有优于一线临床保肝药品水飞蓟宾的降谷丙转氨酶和谷草转氨酶的活性，同时还表现出比抗炎药物雷帕霉素更显著的抗炎活性，具有开发成新一代保肝护肝药品的重要前景。Hangtaimycin及其醇解产物hangtaimycinA的生物合成基因簇和生物合成机制迄今国内外尚未见报道。
发明内容
针对现有技术的不足，本发明的目的是提供一种Hangtaimycin生物合成基因簇及其应用。
为实现上述目的，本发明的技术方案如下：
第一方面，本发明的第一个目的是提供hangtiamycin生物合成基因簇(图2)。
本发明在链霉菌Streptomycesspectabilis CCTCC M2017417基因组测序和生物信息学分析的基础上，发现可能负责hangtaimycin生物合成的基因簇，通过基因簇敲除及发酵产物检测(图3-13)，证明了链霉菌Streptomyces spectabilis CCTCC M2017417基因组中负责曲张链丝菌素生物合成的基因簇。一种Hangtaimycin生物合成基因簇，其特征在于：该生物合成基因簇的核苷酸序列如SEQ ID NO.1的第1-91594位的碱基序列所示，包含21个基因，具体为：
(1)负责hangtaimycin碳骨架合成及修饰的18个基因：
1)1号基因：htmA1位于基因簇核苷酸序列第10986-25451个碱基处，长度为14466个碱基对，编码聚酮合酶，4821个氨基酸；
2)2号基因：htmA2位于基因簇核苷酸序列第25448-47611个碱基处，长度为22164个碱基对，编码杂合的聚酮合酶与非核糖体肽合成酶，7387个氨基酸；
3)3号基因：htmA3位于基因簇核苷酸序列第47611-61857个碱基处，长度为14247个碱基对，编码聚酮合酶，4748个氨基酸；
4)4号基因：htmA4位于基因簇核苷酸序列第1-822个碱基处，长度为822个碱基对，编码游离的酮基还原酶，273个氨基酸；
5)5号基因：htmA5位于基因簇核苷酸序列第9823-10578个碱基处，长度为756个碱基对，编码II型硫酯酶，251个氨基酸；
6)6号基因：htmA6位于基因簇核苷酸序列第79115-80338个碱基处，长度为1221个碱基对，编码游离的失活酮基合成酶，负责脱羧，407个氨基酸；
7)7号基因：htmA7位于基因簇核苷酸序列第83995-85938个碱基处，长度为1944个碱基对，编码游离的酰基转移酶，负责延伸单元的转移，647个氨基酸；
8)8号基因：htmA8位于基因簇核苷酸序列第78787-79113个碱基处，长度为327个碱基对，编码游离的酰基载体蛋白，108个氨基酸；
9)9号基因：htmB1位于基因簇核苷酸序列第61854-69500个碱基处，长度为7647个碱基对，编码非核糖体肽合成酶，2548个氨基酸；
10)10号基因：htmB2位于基因簇核苷酸序列第69515-78790个碱基处，长度为9276个碱基对，编码非核糖体肽合成酶，3091个氨基酸。
11)11号基因：htmB3位于基因簇核苷酸序列第2214-3872个碱基处，长度为1659个碱基对，编码游离的氨酰转移酶，552个氨基酸；
12)12号基因：htmH位于基因簇核苷酸序列第81630-83990个碱基处，长度为2361个碱基对，编码脱水酶，786个氨基酸；
13)13号基因：htmI1位于基因簇核苷酸序列第934-2217个碱基处，长度为1284个碱基对，编码异构化酶，427个氨基酸；
14)14号基因：htmI2位于基因簇核苷酸序列第3932-4564个碱基处，长度为633个碱基对，编码异构化酶，210个氨基酸；
15)15号基因：htmO位于基因簇核苷酸序列第8335-9717个碱基处，长度为1383个碱基对，编码氨基合酶，460个氨基酸；
16)16号基因：htmP位于基因簇核苷酸序列第86021-87256个碱基处，长度为1236个碱基对，编码细胞色素P450氧化酶，411个氨基酸；
17)17号基因：htmS位于基因簇核苷酸序列第80359-81642个碱基处，长度为1284个碱基对，编码羟甲基戊二酸单酰辅酶A合成酶，427个氨基酸；
18)18号基因：htmT位于基因簇核苷酸序列第6346-7692个碱基处，长度为1257个碱基对，编码糖基转移酶，418个氨基酸；
(2)负责调控和转运的3个基因：
19)19号基因：htmR1位于基因簇核苷酸序列第7768-8274个碱基处，长度为507个碱基对，编码转录调控因子，168个氨基酸；
20)20号基因：htmR2位于基因簇核苷酸序列第88943-89740个碱基处，长度为798个碱基对，编码LysR家族转录调控因子，265个氨基酸；
21)21号基因：htmK位于基因簇核苷酸序列第89765-91594个碱基处，长度为1830个碱基对，编码Ser/Thr蛋白激酶，609个氨基酸。
第二方面，本发明提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸序列可利用聚合酶链式反应PCR的方法或包含所述SEQ ID NO.1所示序列的第1-91594位的DNA作为探针，以Southern杂交方法从其它生物体中得到与hangtaimycin生物合基因簇相似的基因。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸序列通过包括体内或体外插入、缺失、置换、突变、与其它来源的同源核苷酸序列进行重组和定向进化方法产生hangtaimycin新结构衍生物。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸列序列可用于通过合适的异源宿主表达，获得更高产量hangtaimycin及其新结构衍生物；所述异源宿主包括放线菌、假单孢菌、大肠杆菌、芽孢杆菌、酵母或植物中任一种。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于特定蛋白的表达及其抗体的制备。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于提高特定蛋白的活性、优化蛋白的动力学特征。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述生物合成基因簇通过遗传改造产生可用于医药、工业或农业的hangtaimycin新结构衍生物。
本发明还提供一种如上述的Hangtaimycin生物合成基因簇的应用，其特征在于：该生物合成基因簇的基因及其蛋白信息用于发现同类化合物、基因或蛋白。
概括来说，本发明的第二个目的是提供hangtaimycin生物合成基因簇的应用，包括以下几个方面：
(1)本发明提供的核苷酸列或部分核苷酸序列，可利用聚合酶链式反应(PCR)的方法或包含本发明SEQ ID NO.1所示序列的第1-91594位的DNA作为探针，以Southern杂交等方法从其它生物体中得到与hangtaimycin生物合基因簇相似的基因。
(2)本发明提供的核苷酸列或部分核苷酸序列，可以通过包括但不限于体内或体外插入、缺失、置换、突变、与其它来源的同源核苷酸序列进行重组和定向进化等方法产生hangtaimycin新结构衍生物。
(3)本发明提供的核苷酸列或部分核苷酸序列，可以用于通过合适的异源宿主表达，获得更高产量hangtaimycin及其新结构衍生物，这些异源宿主包括但不限于放线菌、假单孢菌、大肠杆菌、芽孢杆菌、酵母、植物等。
(4)本发明所提供的氨基酸序列，可以用于特定蛋白的表达及其抗体的制备。
(5)本发明所提供的氨基酸序列，可以用于提高特定蛋白的活性、优化蛋白的动力学特征或其它致力于得到的性质。
总之，本发明所提供的包含hangtaimycin生物合成相关的所有基因和蛋白信息，有助于人们理解hangtaimycin家族天然产物的生物合成机制，以及在此基础上通过遗传改造产生可用于医药、工业或农业的hangtaimycin新结构衍生物，本发明所提供的基因及其蛋白信息还可以用于发现同类化合物、基因或蛋白。
本发明的链霉菌Streptomyces spectabilis CCTCC M2017417是已知菌种，公开于文献：Functional Analysis of Cytochrome P450s Involved in StreptovaricinBiosynthesis and Generation of Anti-MRSA Analogues.Liu Y,Chen X,Li Z,Xu W,Tao,Wu J,Yang J,Deng Z,SunY.ACS Chem Biol.2017,12(10):2589-2597。本申请人保证自申请日起20年内向公众提供该链霉菌Streptomyces spectabilis CCTCC M2017417菌株。
附图说明：
图1.Hangtaimycin的化学结构式。
图2.Hangtaimycin生物合成基因簇。
图3.Hangtaimycin生物合成基因簇敲除重组质粒。
图4.Hangtaimycin生物合成基因簇敲除示意图。
图5.Hangtaimycin生物合成基因簇敲除验证结果。
图6.Hangtaimycin生物合成基因簇敲除突变株ΔhtmBGC发酵产物HPLC检测结果；(A)突变株ΔhtmBGC，(B)野生型CCTCC M2017417，(C)Hangtaimycin标准品；*表示在同样条件下未检测到hangtaimycin。
图7.Hangtaimycin生物合成基因簇敲除突变株ΔhtmBGC发酵产物LC-ESI-HRMS检测结果；(A)突变株ΔhtmBGC发酵产物中hangtaimycin对应[M+H]+抽提和高分辨检测结果，未检测到hangtaimycin对应产物；(B)野生型CCTCC M2017417发酵产物中hangtaimycin对应[M+H]+(理论值m/z 936.45018)抽提和高分辨检测结果；(C)hangtaimycin标准品[M+H]+(理论值m/z 936.45018)抽提和高分辨检测结果。
图8.Hangtaimycin的1H核磁共振测试结果。
图9.Hangtaimycin的13C核磁共振测试结果。
图10.Hangtaimycin的1H-1H COZY的核磁共振测试结果。
图11.Hangtaimycin的HSQC核磁共振测试结果。
图12.Hangtaimycin的HMBC核磁共振测试结果。
图13.Hangtaimycin的1H-1H ROESY核磁共振测试结果。
具体实施方式：
以下实施例是对本发明的进一步说明，而不是对本发明的限制。
1.链霉菌Streptomyces spectabilis CCTCC M2017417基因组中hangtaimycin生物合成基因簇序列和功能分析。
通过对链霉菌Streptomyces spectabilis CCTCC M2017417进行全基因组测序及生物信息学分析，定位了hangtaimycin位的的生物合成基因簇，它包含了21个基因(图2、表1)，其中htmA1、htmA2、htmA3、htmA4、htmA5、htmA6、htmA7、htmA8、htmB1、htmB2、htmB3、htmH、htmI1、htmI2、htmO、htmP、htmS、htmT共18个是负责hangtaimycin碳骨架合成及修饰的基因，以及htmR1、htmR2、htmK共3个是负责调控和转运的基因。
表1.Hangtaimycin生物合成基因簇中各基因编码蛋白的功能分析
Figure BDA0002498827120000081
2、Hangtaimycin生物合成基因簇的功能证明
基于同源重组双交换技术，对链霉菌Streptomyces spectabilis CCTCCM2017417基因组中包含hangtaimycin生物合成基因簇的91887个碱基对进行了敲除，通过产物分析，证明该基因簇是hangtaimycin生物合成基因簇。
表2.Hangtaimycin生物合成基因簇敲除重组质粒构建引物及核苷酸序列
Figure BDA0002498827120000082
Figure BDA0002498827120000091
表3.Hangtaimycin生物合成基因簇敲除突变株验证引物及核苷酸序列
Figure BDA0002498827120000092
表4.Hangtaimycin的NMR核磁归属表
Figure BDA0002498827120000093
Figure BDA0002498827120000101
以下进一步提供实施实例，这些实施实例有助于理解本发明，仅用作说明而不限制本发明的应用范围。
下列实施例中未注明具体条件的实验方法，通常按照常规条件或链霉菌标准操作的条件或按照制造厂商所建议的条件。除非另外说明，百分比和份数按重量计。下述实施例中所使用的材料、试剂等，如无特殊说明，均可从商业途径得到。
实施例1
Hangtaimycin产生菌链霉菌Streptomyces spectabilis CCTCC M2017417总DNA的提取：
取ABB13固体培养基(可溶性淀粉0.5％，大豆蛋白胨0.5％，碳酸钙0.3％，3-(N-吗啉)丙磺酸0.21％，盐酸硫胺0.001％，七水合硫酸亚铁0.0012％，琼脂2％)平板上生长7天，大小约1cm2链霉菌Streptomyces spectabilis CCTCC M2017417菌块，接种至80mL的TSBY液体培养基(蔗糖10.5％，酵母提取粉0.5％，大豆提取物0.5％)，28℃，220rpm，培养48小时。将菌丝体6000rmp离心10分钟后弃上清，收集菌体。将菌体溶于15mL的SET缓冲液(Tris-HCl 0.07％，乙二胺四乙酸0.73％，氯化钠4.39％)中悬浮混匀，重复离心和悬浮两次后，将菌体溶悬重新浮于10mL的缓冲液中，加入50μL的溶菌酶溶液(100mg/mL)，置于37℃水浴锅中温浴1小时。随后加入280μL蛋白酶K溶液(50mg/mL)，混匀后加入600μL 10％SDS，颠倒混匀后置于55℃水浴锅中温浴2小时，此期间每隔15分钟颠倒混匀，直至菌丝体裂解变透明。之后加入4mL 5M的NaCl，颠倒混匀，降温至室温后加入10mL的氯仿颠倒混匀至乳白色。6000rmp离心10分钟，取出上清液后加入0.6倍体积的异丙醇，混匀至絮状DNA析出，将析出的DNA小心挑出并用75％的乙醇洗涤两次，置于通风处吹干，溶于适量的超纯水中。凝胶电泳检测总DNA大小，并测定其浓度和纯度。
实施例2
hangtaimycin生物合成基因簇敲除突变株ΔhtmBGC的构建：
(1)根据Hangtaimycin生物合成基因簇核苷酸序列，在Hangtaimycin生物合成基因簇htmA4的上游和htmK的下游分别设计一对引物(引物序列见表2)。通过聚合酶链式反应(PCR)扩增获得用于同源重组的左右同源交换臂，长度分别为2061个碱基对和2060个碱基对，PCR反应体系和条件为：
Figure BDA0002498827120000121
95℃，3分钟
95℃，30秒；58℃，30秒；72℃，90秒；30个循环
72℃，5分钟
(2)用限制性内切酶NdeI和HindIII双酶切大肠杆菌和链霉菌穿梭载体pYH7，回收其中约9000个碱基对，含有接合转移起始复制位点和氨苄西林抗性基因的DNA片段作为载体，通过Gibson方法与上述两条左右同源臂进行拼接，获得目的重组质粒pWHU-BGC(图3)。
(3)将重组质粒pWHU-BGC转入大肠杆菌DH10B感受态细胞，从转化子中制备的重组质粒经酶切和测序验证正确后，转入大肠杆菌ET12567/pUZ8002菌株中。
(4)将含有重组质粒pWHU-BGC的大肠杆菌ET12567/pUZ8002单克隆转化子接种于5mL含抗生素卡那霉素(Kanamycin，50μg/mL)和阿泊拉霉素(Apramycin，25μg/mL)的2×TY液体培养基(胰蛋白胨1.6％,酵母提取粉1％,0.5％NaCl)，37℃过夜培养，将菌液按10％接种量接种于5mL含抗生素卡那霉素(25μg/mL)和阿泊拉霉素(12.5μg/mL)的LB培养液中，37℃培养3小时。
(5)将TSBY液体培养基中培养48h的链霉菌Streptomyces spectabilis CCTCCM2017417菌丝体用2×TY液体培养基清洗两次，取100μL与用2×TY液体培养基清洗两次的含有重组质粒的大肠杆菌ET12567/pUZ8002菌体100μL混匀后涂布于含10μM Mg2+的ABB13固体平板上。28℃培养12小时后加入1mL含抗生素萘啶酮酸(Nalidixicacid，25μg/mL)和阿泊拉霉素(35μg/mL)的无菌水进行覆盖，待培养基表面干燥后置于28℃培养，5-7天后可见明显接合转移子生长。
(6)将接合转移子涂布于含ABB13固体培养基平板上，28℃下进行松弛培养，5-7天后可见明显单菌落生长。
(7)将单菌落分别涂布在含有抗生素阿泊拉霉素(35μg/mL)和不含抗生素的ABB13固体培养基平板上，5-7天后选取在不含抗生素的平板上生长而在含有抗生素阿泊拉霉素的平板上不生长的菌株作为候选目标菌株，提取其基因组DNA，并在敲除DNA上下游区域设计一对引物(表3)进行PCR验证(图5)，验证正确的菌株即为hangtaimycin生物合成基因簇敲除突变株。
实施例3
链霉菌Streptomyces spectabilis CCTCC M2017417中和hangtaimycin生物合成基因簇敲除突变株ΔhtmBGC中hangtaimycin的发酵提取以及高效液相色谱(HPLC)和液相高分辨质谱(LC-ESI-HRMS)检测：
将SFM固体培养基平板上生长7天，大小约1cm2链霉菌Streptomyces spectabilisCCTCC M2017417和突变株ΔhtmBGC菌块，分别接种至40mL的TSBY液体培养基中，在28℃和220rpm条件下培养36小时，将菌丝体按照2％的接种量分别转接至40mL的SFM液体发酵培养基(大豆粉2％，甘露醇2％，大孔树脂5％)，在28℃和220rmp条件下培养108小时。将发酵液经6000rpm离心10分钟后，沉淀用40mL乙酸乙酯萃取3次，合并萃取后的乙酸乙酯经旋转减压蒸发，浓缩干燥后的沉积物溶解在1.5mL甲醇中，最后经0.22μm的微孔滤膜过滤后进行HPLC(图6)和LC-ESI-HRMS(图7)检测分析。结果显示，与产生hangtaimycin的野生型菌株链霉菌Streptomyces spectabilis CCTCC M2017417相比，hangtaimycin生物合成基因簇敲除突变株ΔhtmBGC未检测到hangtaimycin，证明了hangtaimycin生物合成基因簇的正确性。
HPLC分离条件：A相为超纯水，B相为乙腈。0-20分钟,35-65％B；20-28分钟,65-95％B；28-30分钟,95％B；30-33分钟,95-35％B.33-38分钟,35％B。流速为1mL/分钟，检测波长245nm，柱温30℃。
LC-ESI-HRMS检测条件：Thermo Scientific公司LTQ-Orbitrap XL离子阱质谱仪，Agilent公司HP1100 HPLC system液相系统。
液相条件为：A相为超纯水，B相为乙腈。0-20分钟,35-65％B；20-28分钟,65-95％B；28-30分钟,95％B；30-33分钟；95-35％B，33-38分钟,35％B；流速为1mL/分钟。
质谱条件为：正离子模式检测；离子源喷射电压：4.8kV；毛细管温度：275℃；毛细管电压：15V；鞘气：氮气，流速：45arb；碰撞气：氦气；检测方式：全扫描质谱(分子量范围100-1000Da)。
序列表
<110> 武汉大学
<120> Hangtaimycin生物合成基因簇及其应用
<160> 7
<170> SIPOSequenceListing 1.0
<210> 1
<211> 91594
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 1
atgcctgacc acatacccgg cgcccgcgcc gcgctagccg acagaaccgc cctggtcacc 60
ggggcgggtc agggcatcgg agcggcggtc gccgaggcgc tcgccgccga gggagcccat 120
gtggtggcca ccgaccgcac ggccgacggc gtcaaggcgc tggccgccga ctgggccgcg 180
gacccggccc ggtggggtga gggcgcgggc accgtcaccg ccgaggtcat ggacgtcacc 240
gacgccgcgt ccgtcgaggc cgtggtggcg gcggccgagc gcgcgcacgg cccgctcgac 300
atcctcgtga acgtggccgg aatcctccgc cccggacccg ccgccgaact caccgacgcc 360
gactgggcgg acaccttcgc cgtgaacacc agcggcgtcc tccacaccgc acgcgccgtc 420
accccgggga tggccgcgcg cggccggggc tgcgtcgtca ccgtcggctc caacgccgcc 480
ggggtgcccc gcaccggcat ggccgcctac gccgcgtcca aggccgcggc cgccatgtac 540
accaagtgcc tcggcctgga gctcgcccgc agcggcgtgc ggtgcaacgt cgtcgccccc 600
ggctccaccg acaccgccat gcaacgcgcc ctgtggaccg acgaggccgc cccgcagcgg 660
gtcatcgacg gcgaccccgc cacgtaccgc accggcatcc cgctcggccg gatcgcggaa 720
ccccgggaca tcgcggacgc cgtggtcttc ctcgcctccg accgggcgcg ccacatcacc 780
atgcaggagc tctacgtcga cggcggcgcc acgctccgct gacgcgccgc cgcaccggcc 840
ccatcggccc cctgtcccca ccgccacaac gccctccttc ttcaacagca cacccacgcc 900
caccgtgtcc gtacgcccgc acgcccacgg accgtgagag aaacggagac cctcgtgtcg 960
acggcacccg atgtcgccac gcacgtcccg gccccggccg cccccaccag ggcagcggac 1020
ccggcccgcc ggacggtgga agccgacccg gcgcatcccg ccgtgggggc cgccaccgcg 1080
ctcctcgcgg actacgcgcc aggtgcccgc ttcctcggca cccccacccg gaccctgctc 1140
ggacagggcg tccacagcga agtgccgcac gacgaaagac cgttggccgc acgcgtcgcg 1200
gacaccctcg ccgccgccag ggaagcgggc gccgacgcgc ccgtcgtcat cggtgcggtg 1260
cccttcgacc agggcgcacc ggcggcgctc gccgtgcccg tcgccctgca caccgcgccg 1320
ccgctggccg ccgacccgct cgtcgccctg cccgcccagg caccggccgc cgccgactgg 1380
cgcatccgcc aggtgcccgc gcccgagcac tacggcgcgg ccgtcggcgc cgccgtcgac 1440
cgcatgtggc ggggcgagtt cagcaaggtg gtgctcgccc gcaccctcga actcgacacc 1500
cccgacagcg cggagccggt cgacgtcgcc gcgatgctcc agcgcctggc ccgccgcgac 1560
cccaccggct acaccttcgc gctgcccacg ggccccgagc gcaccctcat cggcgccagc 1620
cccgaactcc tcgtgtcacg gcgcggccgg caggtcgtcg ccaacccgct cgccggatcc 1680
atcccgcgca gcgacgacct ggccgaggac gtgcgccgcg cggcggccct gctgcggtcc 1740
tccaaggacc tgcacgagca cgccgtcgtc gtcgacgccg tccaccaggc gctcgccccg 1800
tactgcgccg acatgaccgt ccccgccgcg cccaccctga tccgcaccgc cgccatgtgg 1860
cacctgtcga ccaccgtcac cggcaccctc gcgcggccgg ggacctccgc gctcgaactc 1920
gcctgcgccc tgcaccccac cccggccgtg tgcggcacgc cgaccgacac cgcccgcgag 1980
gtcatccgcg agagcgagcc cttcgaccgc ggcttcttca ccggcatggt cggctggggc 2040
gacgcctccg gcgacggcga gtgggtcgtc accatccgct gcgcggaggc cgagcggaac 2100
tccctgcgcc tgtacgcggg cgcgggcgtc gtcgccgcgt ccgagccggc ggcggagacc 2160
gcggagaccg ccgcgaagtt ccgtacgttc ctcgccgccg tgggggccga gctgtgacca 2220
ccgagacgcc cccgaccgcg gggccccgga cgcccacctg gcccgaggag ttcgccgccc 2280
gctaccgcgc ggccggatgg tggcgcggcg agaccttcgg gaccatgctg cgcgagcgcg 2340
ccacggccca cccggaccgg acggcgatcg tcgaccccgc caccgaccgc cgctggacgt 2400
acggcgaact cgacgcgcgc gccgaccggc tcgccgccgg gatgctcgcc cgcggcatcg 2460
cgcccggcga ccgcgtcgtc gtccagctcc ccaacatcgc cgagttcttc gaggtggtct 2520
tcgccctctt ccggatcggc gcgctgccgg tcttcgcgct gcccgcgcac cgcgagacgg 2580
agatcgccta cttctgccgc ttcaccgagg ccgccgccta cgtcatcgcc gccgagcacg 2640
ggggctacga ctaccgcgcc ctggccgcga ccgtccgcgc cgaggtgccg acgctgcggc 2700
acgtgtgggt cgcccagggc gaaccggggg agtgcacggc cctggacgac gtgcgcgccg 2760
atggcgaagg ccccgcggag ctgcccgcgc ccgcgccgca ggacctggcc ttcctccagc 2820
tgtccggcgg cagcaccggc gtgcccaagc tgatcccgcg cacccacgac gactacatct 2880
actccctgcg cggctccaac gagctgtgcg gcgtcgacga gcacagcgtc tacctgtgcg 2940
tgctcccggc cgcgcacaac ttcccgctgt cgtcgcccgg aacgctcggc gccctgtacg 3000
ccggggcccg cgtcgtgctc agcccgagcc cggaccccga gaccgccttc tccctcatcg 3060
cgcgcgaagg cgtcacgctc accggcctgg tgccgccgct cgccctgctg tggacccagg 3120
ccgccgccac caccgcccac gacctgagca gcctcgacgt cctcctcgtc ggcggcgcca 3180
agttcagcga ggaagcggcc cggcgcgtcc gtccggccct cggctgcacg ctccagcagg 3240
tgttcggcat ggccgagggc ctggtcaact acacccgcct ggacgacccc gaggaagtca 3300
tcgtcaccac ccagggcagg ccgatctccc ccgacgacga gatccgcgtc gtcgacgacg 3360
cggacgacga cctgccgccc ggctccaccg gacacctcct gacccgcggc ccgtacacca 3420
tccgcggcta ctggaacgcc cccgagcaca acgcgcgctc cttcaccgcg gacggcttct 3480
accgcaccgg tgacatcgtc cgcctcaccg acaccggcca cctggtcgtc gagggccgcg 3540
ccaaggacca gatcaaccgc ggcggcgaga agatcgcggc cgaggaggtc gagaaccacc 3600
tcctggccca ccccgccgtc cacgacgcca acgtcgtcgg cgagcccgac ccgtacctcg 3660
gcgagcgcac ctgcgcctat gtgatcctgc ggcccggagc cgagccgctg aagcccttcg 3720
cgatgaagcg cttcgtgcgc gagcggggcc tcgccgcgta caaggtcccc gaccgcgtcg 3780
agttcgtgga cgccttcccg cagaccggcg tcggcaagat ctccaagaag gacctcagag 3840
cggcggccgc cgaacggccc gccacgccct gacgggcccg gcccctcacc tccgacccac 3900
tgacccacac ccggacggaa cgcaccgcac catggccctg cccaccatca cgccctaccc 3960
catgcccgtc gccgcggacc tgcccgccaa ccgcgtcgac tggaaggtcg acccggcccg 4020
cgccgtgctc ctcgtgcacg acctgcagaa ctacttcctg tccgcgtacg acgccggggc 4080
cgcgccggtg cccgaactgc tgcgcaacgt cagcgccttg aaggagcgcg cgaactccgt 4140
cggcatcccc gtcgtctaca ccgcgcagcc cggcggccag acccccgccg aacgcggcct 4200
ccagcaggac ttctggggcc cgggcctgcc ggacgacccg caggcggcgg ccatcgcggg 4260
acccgtcgcc ccgggccccg gcgaccaggt cctcacgaag tggaagtaca gcgggttcgt 4320
ccgtacgtcc ctcgcggacg acctccgcgc ccagggccgt gaccagctgg tcatcaccgg 4380
cgtctacgcc cacatcggcg tcctgatgac ggcgtgcgac gcctggatgc gcgacatcca 4440
ggccttcgtg gtcgccgacg ccgtggccga cttctccgcc gacgaccacg ccatggccct 4500
gcgctgggcc gcgggccgct gcgccgtggt cacgaccacg gacgaggtcc tgaagggcgc 4560
ctgaccaccg acgcgcccct gaatttcaga tgcttcgcag gtgcgtcggt ccctaggctc 4620
cccgccatgg acagcaacgg caccgaccac ctcctgaacg tcgtggacgt cgaggccacg 4680
tgctggcccg gctcaccgcc gcccggcgcg gtcagcgaga tcatcgagat cggcctgacc 4740
gtcgtcgacc tggccgccgg gcgacgcgtc gcccggcacc gcgtcctcgt acgcccggag 4800
cgctccacgg tcagcgactt ctgcacggaa ctgaccggcc tcagacagca cgaggtcgac 4860
gcgggcgtcc ccttcaccga cgcctgccga ctcctcgcgg ccgagcaccg ggccggggtc 4920
agggcctggg cgagctgggg cgactacgac cgccgccagt tcgcccggca gtgccgggcc 4980
accggcacgc cctacccgtt cggcgcgcgc cacatcaacg ccaaggccgt cttcacggcc 5040
gcgcacggac tgcgcaaacg ccccggcatg gcgcaggccc tgcgcatcgc cgggctgccc 5100
ctcgaaggcc ggcaccaccg gggcgaggac gatgcctgga acatcgcggc gctcgtcgtc 5160
ggtctcgtgg gagccgggag ctggccgtga accaagagag tgccaagggg agttcaagaa 5220
tttcccactg gtctacacct tgactggtat agaccaaggc gggttgactg cgccccagtc 5280
cgtctcggcc ccccagcgtg gctcgctgcc gcatcgagga gtgaagagat tgaacgagcg 5340
caagccaaga agaggtgtca ccgcccggtt ccgcgaacgc gcgcggcggc tgcggccgtt 5400
gctcgcggcc tcggcggcca ccggcgtcgc ggccctcctg gccaccctgc ttcccgcgtc 5460
gaccgcggcc gccgccccgg ccgcggcccc cgcctgcgcc accgcctggg actcggggtc 5520
ggtctacacc aacggctcca ccgtgtcgca cgggaagcgc aactggcagg ccaagtggtg 5580
gacccggggc gagacccccg gcaccaccgg cgagtgggga gtctgggtgg acaaggggga 5640
gtgcggcacg ggtggcggga accccgaccc gggcggcttc atcgtgagcc aggcccagtt 5700
cgaccagatg ttcccgaaca ggaagccctt ctacacctac cagggcctgg tcgacgcgct 5760
gaaggcctac ccggagttca ccaagaccgg cagcgacacc gtgcgcaagc gcgaggccgc 5820
ggccttcctc gccaacgtca gccacgagac cggcggcctc gtccacgtcg tcgagcagaa 5880
ccaggcgaac tacccgcact actgcgacaa gacccagccc tacggctgtc ccgcgggcaa 5940
cgacgcgtac tacgggcgcg gccccatcca gctgagctgg aacttcaact acaaggccgc 6000
gggtgaggcg ctcggcctcg acctgctgaa caacccctgg ctggtcgagc gcgatccgtc 6060
cgtggcatgg cagaccggcc tgtggtactg gaacacccag aagggcccgg gcaaggtgac 6120
gggccaccag gccatcgtcg acggccacgg cttcggcgag accatccgca gcatcaacgg 6180
caccctggag tgcaacggcg gcaatccggc ccaagtgcag agccggatca accgctacca 6240
gcagttcgtc cagatcctcg gcaccacccc gggcgacaat ctgagctgct gacatcatcc 6300
cgagccgccg cgccccgccg gcacggggcg cagcggctcg ggcctgcgga gaaccagcgc 6360
gatcgcgtcg ttctccgcgc gttccggctc gcgccggctc gtcgtgcacc catactggcc 6420
gccgtgcggg ttgcgatgat gacagcgggc tcccggggcg acgtcgcccc gttcaccggc 6480
ctcggcgcgg gcctcgtccg ggccgggcac gacgtgacct tggtgacgca cgacatgttc 6540
gagcccctga cgcggggctc cggcgtccgc ttccatccgc tgcccgtcga cccgcgggcg 6600
gagctgcact ccgagcgcgg ccagggcctg caccgcagcg gcaccggcgt gggcaagctg 6660
ctgcgggcca tgtcgatggg cagggccgtc gtggggcagt tcaccgacag cctcatcgag 6720
gtggccgagg acagtgacgt gctggtcctg gccggtgtgg tggccccgct gggctgctcc 6780
gtcgccgagg gcctgaagct gccgagcgtc ggcgtcaatc tccagcccat gcacgccacg 6840
cgcgcgttcg cgcccccgct ggccaccgtg cgctcgctcg gcccggtggg caaccgcctg 6900
gccgggtacg cggtcaccgc cctcatcgag cagatcttca cccgggccgc ccgggaggcg 6960
cgcgagcggc tgcgcctgcc gccgctcggc gtcggggccg cgcgccgcgc ccgcgaacgg 7020
cagggctggc cggtcctgta cggcttcagc ccgcaggtcg tggcccgccc cgccgactgg 7080
cgccccggcc tcgacgtggt cggctactgg tggccgcacg acgtccagga ccaactgccc 7140
gcagaactcg aggacttcct cgccgccggt cccgccccgg tctacgtcgg cctgggcagc 7200
gccaccgtcc ccgacccggc ccgcctctgc ggccaggtcg tgagcgccct gcgcgcggcg 7260
ggcctgcgcg gcgtgatcca gcgcggctgg gcgggcctgt ccgccaccgg cgacgacatg 7320
ctcaccatcg acgacgtccc gcaccgcctg ctcttccccc gcaccgccgc cgtcgtgcac 7380
cactgcggcg cgggcacgac cgccgcgggc ctgcgcgcgg gcgtccccgc cgtgcccgtg 7440
cccgtccagt tcgacgagat gttctgggcc gaccgcctca cggccctggg cacggccccg 7500
tacccgctgc ccctgcgcag gctgaccacc cagcgcctca ccgacgccct gatccgggcg 7560
acgggggacc ccggccaccg ggagcgcgcg cgccttgtgg caggccgcct ggccgccgag 7620
gacgccgtcg gtcccgtacg ggacctgctc cagcgcatcg agagcggcga gcacggcgcc 7680
cgcgtcccct gagccgcgct ccggaagatc gtccgcttga cctcaagcaa acttgaggtc 7740
atacgttctc cccatggccg gcacggagtg cgggcctcgc accacagcaa cgggagggga 7800
cacaccatgt cgaaccagca gatcactgac gctcagctcg ccggacagcc cgccgcatac 7860
gtgaccggtc tcgcctacga ggcgctcatc gcgttcaccc gggcccggca ggaggagaag 7920
ggctacaccc agccccagtt ctggctgctg cgcaacctgt cggagaacga cctctcgccc 7980
gacgggcagg ggatgaccgt gccccagctg caggacgcca tggcctccta catccggccc 8040
gaggacgatc tggcggcgga ggccgatgtg ctcctggagc gcggctggct gacccgggac 8100
gccgacggcc ggctgtggct caccgaggag ggggagcgga cccgcgtcga cctcaagcgc 8160
aacgcccccg cgatccgcgc cgccctccac cagggcatcg acgacgccga ctacgtcacc 8220
acggtgaagg tgctccagca gctgatccgc aacgcgggcg ggaagaccgc ctgacgggcc 8280
ggaggggccg ggccgcccgg cccggcccct ccggcccggt gcgtgcgcgg caggtcagcc 8340
gacgtagacc tgcggcgtgc ggtcccgcca cgggacggcc tgctccagct gggcggcgac 8400
ctggagcagc aggtcctcgc ggccgtgcgc ggcgaccagc tgcacgccga tgggcaggcc 8460
ctcgcggctc tggccgaggg gcaggctgat cgccgggttc cccgacacgt tgaacgtggc 8520
ggtgaagggc ccgtacgtga acaggcggtt cagccacgag cgcgccgagt gcccgtcgtg 8580
gtcgtagttg agggtcccgt gcggcgcggg cagccggccg agcgtgggcg tcaggagcag 8640
gtcgtgctcc tggaagaagc ggccgatcga ccgcgtcacc acgttctgcg cctcggtcgc 8700
ggacatcacg tcgagcagcg tgaactcctc ggtctcggag agcacgcgcc gcgacacccc 8760
ctccagcgtc gcggggtcgg gcctgcgggg cgtgccgcgc agcacggcgc cgccggtggt 8820
gacgaccgtc agcatcgcgg cctcgatgac ggcgctgccg tcgacgtccg gtgcggcctc 8880
ggtcaccgcg tggccgatcc actccaggac ctggcccgcg gtgaccgccg cctccgcgac 8940
ctgggggtcc accgtgccgc cggtccacgg ccgggtggtc agggcgatcc gcagccgccc 9000
ggggtcggtg cggatcgcct cggcgtacgg ccgggcgggc ggcggcgcct ggtacttgtc 9060
gccgacggcg ggcgcgcaga cggcgtccag gaggtgggcg gtgtcccgca cggtgcgcgt 9120
gaccgcgaac tccaccagct gcccgaaagc ggtttcaccg ctcatcggcc cgcacggcgt 9180
gcgccccagg cccggcttca ggccgacgag gccgcacgag gaggccggga cgcggatgga 9240
gccgcccgcg tcgttcgcgt gcgccaacgg caccgcgccc gccgcgacca gggcggccgc 9300
gccgccgctc gacccgccca cgccgcgctt cgggttccag gggttgcggg tcgggccgta 9360
gcgcaccgac tcggtggcga agctcagacc gaactccggc gcggtgctct gcccgagcgc 9420
caccaggccc gcggcccgga accgggccat caggtcgtgg tcgaccaggg cgtacgcgcc 9480
ctggacggcg cggctgccga tggtgaacgg cacgccctgc gcgaagggcc cgctgtcctt 9540
gatgacgaac ggcaccccgc cgaaggggcc atcgggctca tgggccaggg acgggtcgaa 9600
cggcggctgc gtcagcgcgt tgagctcccc gtcggcctgc tcaagggcgc gccgcgcaca 9660
ggcctcgacc tcggccgcgc tcacctcgcg cgtccggatc agctcacgca gccccaccgc 9720
gtcgaaggac gcgtactcgt cgagctccag cgctcccagc tccttttacc gtgttcgtcc 9780
gtgttccgtg ttcgtccgtt gctctcgcgt acggggaagg ggtcagcggc ccggcgccgt 9840
ggcgccgagg tggtcggtga tctcccgcac gaccgactcg gtgtgatcgc cgaggaagaa 9900
gtgaccgccg gggaagacgc gcagccggaa cggcgccacg gtgtgctgcg cccaggccct 9960
ggcctcggcg acgtcgacca gcgggtcgct gtccccggtc agcgcgagga ccgggcagtt 10020
caggggcgga cccggccggt agcggtaggt ctcgatggcg cggtagtcgc cgcgcatggc 10080
gggcaggacc atcgccagga ccgcctcgtc ggcgagcagc tccgagtcgg tgccgctcag 10140
ccgccgcagc tcctcgacga gcccctggtc gtcgcgcagg tgcacgtgct cctcgcgctg 10200
ccgcgacggc gcccggcgcc cggaggcgaa caggccgtgc aggatgacac cgcgtgcctc 10260
caggcgcctg gcgacctcga aggcgaccgt ggcgcccatg ctgtgcccga agaacgtcag 10320
cggccggtcg gccaagcctg cgagctcatc ggcgagccgg tccgcgaggg tggaaatgtc 10380
cgtgatgcac ggttcttgga ggcggtcctg ccgaccgggg tactgcacgg ccagcacgtc 10440
cgccgctggt gagagcgcgg cggagaacgg gaagtagtac gtcgccgagc cgcccgcgtg 10500
cgggaagcag acgacgcggg cgcccgtctc cggtgccgga tggaaccgcc ggacccaggc 10560
gctgccggtc gctgccatca cggtgcctct tctccgcgtc gtgccagtgg cgcaggtcag 10620
ccggggggtg tccggtcctg ctggtggtgc tcgggcgcga gtggtgcgcg agcgagggct 10680
accctaagct ccgcgcgccc ccgatgtgac accggagggg gtccgggggc gctgaggtat 10740
atttcgagcc actgcggcga tcggctcgtg actccgtccc cgcagctcgc acccactggg 10800
tccgcgggcc accatgaatt ccggacaacc ggaacacgcg actgccgtcg aggcatggaa 10860
attggtgctt gacggttggc cctttcgtga cgcagtgttg cgggacagtc gtcagtgagt 10920
aggcgagtta gacggctgct cgacggtggg aaacgccggg cacgggggac ggggcgtacg 10980
tacacatggt tcagcagcgc actgacgtca ttcggcacgc ccgtctctcc gatatgcctc 11040
ggcttctcga actcgaggag ttgtgctggg cggagccgct gcgcgtctcc gaagaagtca 11100
tccggcggcg ccttttctcc tatcccgtcg gtcagttcgt cgtcgagtcc gacggcgcgg 11160
tgcacgccgt catctactcc cagcgcatcg ggagtccgga cgacgtgttc tccgcgacct 11220
tcgacacggc cgaccgtttg caccgccccg acgggccggt cgcccaggtc ctctcgctga 11280
acgtcgaccc gtcgaagcag agcttccgtt tcggcgacat gctgctggaa cacctcctga 11340
cgtgggccga tggcgaggcg tccgtgcgga ccgcggtcgg cgtgacccgg tgcagggact 11400
tcggcaggca cccggaggcg gagctggccg cgtacatccg cgcgacgaac gtacagggcc 11460
gctgcctgga caccgtcctg cgcatgcacc agctgcacgg cgccgagatc cgcgcgctcg 11520
tcccgggata tcggccgggc gatctggtca acgagggaaa cggcgtcctc gtcgtctacg 11580
acctgtcgga ccgtcaggag cgagtgcgaa ttctccatag cgaaggagag aagtccgcgg 11640
cggcctccat tccgcccggc ggacaactgg ccgtagaaat acgggagttc ttcgacgcta 11700
tactcggcgg cgactacgag ggaatcgaac accctataga aagccctctc ttcgagctgg 11760
gattcgactc cgcggggctt ctggatcttc aggaaaagat cgaatcccga tacggaatcg 11820
gactcgcccc cctcttcttc ttcgagcaca acaccggcgc cttgatcgtt tcctatctgg 11880
aagatctcag gggcgaggaa acaagccatg cgccggacgc ccggccgacc gccgtggccg 11940
ccgcgcctgc cactcccgct ccgcctgccg ctaccgccgc cgctccgcct gtcgctcccg 12000
cctcgcccgc tgcggccgct cgggccgagc gctccgacga ctcccgtgac gtggcgatca 12060
tcggcaccgc gtgccgtctg cccggcggca tcgaggaccg cgccggactg tgggagctgc 12120
tcacgtccgg ccgcagcgcc gtcggcaccc tgcccgaggg gcgctggcag tggcccgacg 12180
gcacggggcc cgacacccac cccggcatcg accgcggcgg attcgtcacc gacgcggggg 12240
ccttcgaggc gggcctgttc cgcgtcaccc cgtacgaggc gcggcacatg gacccgcagc 12300
agcgctggac cctcgaactg gcctgggcct gcctggagga cgccggatac gcgccgggcg 12360
ccgtcgcggg cacgcggacg ggcgtcttcg tcggcgccag cggctcggac taccagcgcg 12420
tcatggacgc ccgcggcgtg cccgtgcgcg cgcacagcgg cctggcgacc tccatggccg 12480
tcatcgccaa ccgcgtctcg tacttcttcg acctgcgcgg cccgagcgtc cagctcgaca 12540
ccgcctgctc cagctccctc gtcgccgtgc acacggccct gcgcgcgctg cgcgcgggcg 12600
agtgcgacac ggccctggtc ggcggcgtca acgtgctgtg ccacccggcc aacagcatcg 12660
cctaccacca ggcgggcatg ctgtcgcccg acgggcagtg caagaccttc gacgcctcgg 12720
ccaacggcta tgtgcgctcc gagggcggcg tcgccctgct cctcaagccg ctcgccgccg 12780
cgctcgccga cggcgacccg gtgcacgccg tcatcaaggg cagcgccacc aaccacggcg 12840
gccaggcggg cggcctgacc gtgcccagcg ccgccctcca ggcgagcctc gtcgaagccg 12900
ccctcgccga cgcgggcgtc agcgcgcgcg acatcggcta cgtggaggcc cacggcaccg 12960
gcaccgccct cggcgacccc atcgaagtcc aggggctcac caaggcgttc gccggaagcg 13020
acgcgccctg cgcgctcggc tcggtgaaga cgaacctggg ccacctggaa gccgccgcgg 13080
gcatcaccgg actgctcaag accgtcctcg ccctccagca ccggcagctg cccgcctcgc 13140
tgcactacga gcgccccaac ccgcacatcg acctggacgc ctcgccgttc tccgtcgtga 13200
cccgcctctc ggactgggac ctcgacgggc gccccgcccg ccgcgccggg atcagcagct 13260
tcggctcggg cggcagcaac gcccacgtcg tcgtcgagga gttcccggcc gccgcggagt 13320
ccccgcgcgc cggagccgcg ccgcacgcgg acggccgcgg cggcgaaggg ccctcgatgg 13380
tcgtcctgtc cgcccgcagc accccccaac tgctgcgcca ggcccggcgc ctgctcgacc 13440
acctccggca ggagcgcccg gccgacgccg acctgaggga catcgcgtac accacgcagg 13500
tgggccgcgc ggagctgccc gagcggctcg gcctgccggt gacgagcgtc gcctccctca 13560
ccgcgctcct cgacgacttc gtggcgggcg tcccgtcgcc cgccgtcctg cgcggccgcg 13620
ccgagcggga cgccgcaccg caggccgccc ccggcgccac ggccgaggac gtcctggccg 13680
cgtgggtgcg cggcgccggt gtcgactggg aggcgcacca cgcaggcggc gcccggccgc 13740
gccgcgtccc cctgcccacg cacgccttcg accgcgacca ctactgggtc ggcgacgaac 13800
ccgccgccga cccgtcccga gaccgtgcgg accaggacct gcccgccgcg caggccgcac 13860
cccggcaccc cttgctccag cgcgcgacgc cggacgcgga cgccctcgcc gccttcgatt 13920
ccaccctcgc cgcggaggac ttcttcctgc gcgaccaccg ggtggcgggc gagccggtgc 13980
tgcccgccgt cgcctccctg gagatggccc gcgaggccgc gagccgtacg ctgcccgccg 14040
ccgacggcgc ggaagtgctc cgcctggaga acgtggtgtg gtcgcggccc gtcgtcgtac 14100
cggacgggac gcggacggtc cgcacggtcc tgacggagag cgcgaacggc ccggccaccg 14160
gccagggtcc ggccaccggg gacgccccgg cctcaggcga tgcgtcggcc gcgggggacc 14220
gcccggtcgc cttcgagatc cgtgccgccg acgtcgtcca cgcgcgtgga gtggcctcgc 14280
gcacgcggac ggccccgccc gagcccctcg acctcgacgc cctgaagtcc cgtacgggcg 14340
cggcggtgct cgacatcgac gacttctacg ccacgctgcg cgccaccggg ctcgactacg 14400
gccccgcgca ccgggcggtg cgcgagatcc gcctgggcga cggcgaactc ctcgccgcgc 14460
tcgccgtgcc cgacgaggtc gcggccaccc tcgacgacta cgtactgcac cccagcgtgc 14520
tcgacggcgc gctccaggcg gccttcgcgc cggacgtccg ggcggcggaa gcgggcggcc 14580
tcgcgctgcc cttcgccctc gaccgcgtcg acgtccacgg agcgacgccg agcgccgcgt 14640
acgcgtggat ccgcgcggtg ccgaccgcct cgcgccaggt gcggcgctgg gacctcgacc 14700
tctgcgacgc ccagggaagg atcttcgcgc ggctgcgcgg ctactccatg cgcaagacca 14760
cggaggccac cggggagccg ggggccacgc acgacgtgac actgttccgc ccggtatggc 14820
gcgcggccga cgccccggcg gacaccgggg cgcccgcgca cacggcgagg ctcgtgctcg 14880
cctgcggctt cgacgaccgg ctcgacgaac tgcgcggcct ggccccagaa gtaacgttcc 14940
tggagccgcc cgagcaggcc gccgccaccc ggaaggccgc cccggtggcg gacgccgtcg 15000
ccgagcacgc cgtcgaactg ctccgcgcgg tacgcgggct gctcatcggc aagccgaccg 15060
gatccgtgct cctccaggtc ctcacccacg ccgacggcga acaggcgctc caccaggcgc 15120
tttccgggct gctgcgcacg gcccgcctgg agcaccccgc cctcgtcggc caggtcgtcg 15180
cggtgcccgc cgacgcctcg gcggcacacc tcgccgagat cctggaggcg gagagccgcc 15240
gcacggacga ccagcgcgtc agccacggcg acggaacccg cacggtcctc gcctgggaac 15300
ccctggacga gagcgccgcg cccgaggcgg cgcccgtgcc gtggcgcgcc ggaggcgtgt 15360
acctcatcac cggcggagcg ggcggcctcg gccggatctt cgccagggac atcgcgcggc 15420
gcgcccccgg agccgtgctg tgcctgaccg gcaggtcccc gctcggcccg gcgatcgagg 15480
cggagctggc ggcgctgcgc gccgagggcg cgcaccccga gtaccacgtc ctcgacgtca 15540
ccgacgcgcg cgccaccgag cgcctcgtcc gcaagctgac gcgacgtcac aaggccctgc 15600
acggtgtcct gcacgccgcc ggagtcctgc acgacgcctt cctccagcgc aagcccgtcg 15660
cggagttccg ccgcgtcctc gctcccaagc tggccggctg ccacgccgtc gacgaggcca 15720
ccaagggcct cgacctggac ttcttcgcgc tgttctcgtc cgtcatgggc gcgaccggca 15780
acgtgggcca gggtgattac gccgtggcca acgccttcct cgacgagttc gcacgccacc 15840
gcgccacccg cgtcgccgcg ggcgagcgcg gcgggcggac cctgtcggtc gcctggccac 15900
tgtggcacgg cggcggcatg ggcgccgacg aggacacccg caaggccctg cggctgcgcg 15960
gcggcttcct gccgatggcc acggacgccg ggatcgacgc gttccaccgc gccctggaca 16020
gcgccgagcc gcacgtcgtc gtctgggccg gagagcgcgc ggcgggcacg cgcgcgctcc 16080
tggacgcggc acccgccccg gagacggtca gggccactcc cgacgccggg cgggccacga 16140
gcaccgggca ggccacgggc gcgcccgacg agcgggccct gcgcgcccgc accctggagt 16200
tcgtcaaggc ggagctgtgc cgcctcaccc agctgccgcc cggcgagatc gacgacgccg 16260
agcccctggg ctcgtacggc atggactcga tcctggcgac cgagctgacg gcgggcctgg 16320
agaagacgtt cggctcgctg ccgaagacgc tgctgttcga gtaccacacg ctcgccgagc 16380
tcggcggcta cttcctcggc ggccaccggg ccgtcctgga gcagatgttc gcggacggcg 16440
gcgccgagcg ggcggaggca caccccgaag ccgtggcgcc cgagccgccg cgtgcggcgg 16500
tcacgacggc cctccgcgag gctcccgcag cggacgagcg cgccgccgcc cccacggcgg 16560
aggactccgc cctggacatc gccgtcatcg gcctgtccgg ccgctacccc gaagcgcggg 16620
acgtccgcga gttctgggac aacctgcgcg ccggacgcga ctgcgtcgtc gaggtccccg 16680
aggaccgctg ggactggcgg gagtactacg agcaggaccg caccgtgccc ggccgccact 16740
acagcaagtg gggcggcttc atcggcgagg tggaccgctt cgacccgctg ttcttcaaca 16800
tcgcgccgca cgaggccgac tacctggacc cgcaggagcg gctgttcctg gagcacgcct 16860
ggaccgcgat ggaggacgcc gggtacaccc gggagcggct cgggcgcgcc accggggacg 16920
gcgccgccgg gcgggtcggc gtgtacgcgg gcgtgatgtg gggccagtac cagctgctgt 16980
tcccggacgc gggcgcgggc cgcggcaacc cgcacgccct cggcagcagc tacgcgagcg 17040
tcgccaaccg cgtctccttc gtgctgaacc tgcacggccc gagcatgacc gtggacacca 17100
tgtgctccag ctcgctcacc gccgtggagc tggcctgccg cgacctgcgc agcggccgca 17160
cccggctcgc cttcgcgggc ggtgtgaacg tgaccgtgca cccgaacaag tacctgggcc 17220
tgagcaccgg ccagttcatc tcgagccagg gccactgcga gagcttcggc gtcggcggcg 17280
acggctacat acccggcgag ggcgtcggcg tcgtcctgct caagccgctg cgcgacgccg 17340
agcgcgacgg cgaccccgtc tacggcgtca tcaagggcag cggcgtgtcc cacggcggac 17400
gcaccaacgg ctacacggtc cccaacccgc gtgcccaaca ggccgcgatc caggatgcgt 17460
tgagcgagtc cggcgtcgac cctcgggtca tcagctacgt cgaggcgcac ggcacgggca 17520
cgaagctcgg cgaccccatc gagatcaccg gcctgagcca ggccttcgcc gccgcgtccc 17580
cggacggcac gggcaccggc accggctccg gcttgggcgc cgacgcccgg tgctacctcg 17640
gctcggcgaa gtccaacatc ggccactgcg agagcgccgc gggcatcgcc gggctcacga 17700
aggtcctgct gcagctccag cacggccaga tcgccccttc gctgcactcc gcgacgctca 17760
acccgcacat cgacttctcg cgcacgccct tcgtcgtcaa ccaggaactg cgcgactggg 17820
agcgccccgt cgtcgacgga cggccgcagc cgcggatcgc cggagtctcc tcgttcggcg 17880
cgggcggcgc gaacgcgcac ctgatcgtgg ccgagcacac cgaccgccgc cccgcccccg 17940
caggacacgg cccgcagctg ttcccgctct cggcgaagga cgacgcacgg ctgcgcgcct 18000
acgccgagcg gctgctggac ttcgcgcggg acaaggccct cgcgcagggc aaggtcgagg 18060
ccgccgacgt gacccccgcg gacctcgcgt acaccctcca gaccgggcgc gaggccatgg 18120
acgagcgcct cggcgtcgtc gccgactcct tcgccgcgct cgccgagaag ctggagcgcc 18180
acctggccgg tgacaccgcc gtcgacggcg tctgccgcgg caacgccaag cggggccgca 18240
aggccctggc cgtcgtcccc gccgaggaac tcgccgagac cgtcgcaact ctggcgcggc 18300
gcggcaagct gcccgagctc ctggagctgt ggacgcgcgg cgccgccccc gactggcagt 18360
ccctgcacgc cgacgcggcc gccgtgccgc gccggatcag cgcgcccacg tacccgttcg 18420
cgcgcgaacg gcactgggta ccggaggccg ccgcacccgc ttcgcctccg cccgccgcgt 18480
ccggtacggc gtccggtacg gcgctcttcc tcaccaagca gtggcgcccc gccccctccg 18540
ccccgggccg gtccgggctc tccggtgtcc tcgtcctgca cgaccgcgcc acccggcacc 18600
tcgccgagcg gatcgccgga ctcgtcgacg gcgccacgcc ggtggacgcg acggaccccg 18660
gcgcggacgg cgtcgtcgac cggtgtgccg cggcatgctc cgccctggtc gacctgaccg 18720
ggatcggcga cgacaccgcc ccggccgggg gcatcgaccg gatcgcggag gacagcgcct 18780
ccggccgcgc gctcgcgctg ctgcggcgcg tgctcgacgc gaaggcgtcg cgggacgtcc 18840
tgctgctgtt cgtgacccag ggcctggaga ccacccaggg cctggagacc gcccagggcc 18900
tggagaccgc ccagggcctg gagaccgccc agggcctgga gaccgcccag ggcctggaga 18960
ccgcccaggg cctggagacc gcccagggcc tggagaccgc cgacgccgcc gcgtcccgcc 19020
gcgtcccgct cgcgggggcc gcgcgtgccg cgctctaccg gctgctccag agcgagtacc 19080
gcggcctcgc ctcccgccac gtcgacctcg accccgccgt gcgcgacgcc gccgcgctcg 19140
cggccgtcgt ccacggggaa ctcctcgacg acggacgcgc gccggaggtc tgccaccgcg 19200
acggcacccg gctcgcgccc gtgctcgccg aacccccggc gcccaccgcg gcccggcgca 19260
ccccgcccgc cttcgccccc gacgaggtcc tgctggtgac cggcggcacc cgcggcatcg 19320
gtctgctgtg cgcccagcac ttcgtcgccc ggcacggcgt acgacggctt gtcctgacgg 19380
gccgcgagcc cctgccgccg cgccacctgt ggtcggaccc ggaggcctgc ccgcccgccg 19440
tacgggcgaa gaccgacgcc gtcgccgccc tggaggcgca aggcgtcgag gtgcgggtgc 19500
tcgcgctgcc gctggacgac gcggacgcgg tggcgacggc cgtcaccacc gtcgagtcga 19560
cgctcgggcc gatcgcgggc gtgctgcacg cggcgggcct cgtcgacacg agtaatccgg 19620
cgttcgtccg caagccggtg gccgacatcg cccgggtcgt ctcgccgaag gtcgacggca 19680
ccgtgcacct gctcgcggcg ctcgacccgc gcgccctgcg cttcgccgtc ctcttctcgt 19740
cggtctccgc ggccctgccg ggcctcggcg ccggacagag cgactacgcc atgggcaacg 19800
ccttcatgga ctacttcgcc caggcgcgcg cccacgaact gcccgtcacc agcgtccagt 19860
ggccgagctg gcgcgagacc ggcttcggcg aggtcacgaa caagacctac accgacacgg 19920
ggctgctcag catcaccaac gccgaaggcc tcgccttcct cgacgagatc ctcaccgcgc 19980
cgcgcggacc cgtggtcatg ccggtccggg tcgacgccgc ccgcttcgac gcggccgccc 20040
tcctggacgc gcgcccggcg gccccggccg ccccggcgcc ccaggcccgt accgtcgagg 20100
cccgccggga caccgccggg accgcgcccc tcagggccct gctcaccggc ttcctcagcg 20160
acaccttcag cggcgaactg ggcctgaagt caggccagtt ggacgaggag acctcgtacg 20220
ccgactacgg cgccgactcc atcctgctcg cgcaggtcct ccagcggatc cgccagcgcc 20280
tcgacgtgcc gctcgacccg tcggtcctcc tggagtaccc gaccctgagc gagctcgtga 20340
cctggctgct cgacacctat cccgccgagg tcgccgcgca gttcggcgcc gagccggagg 20400
cgcggcccgc gccgaccgcc cgtaccgcac cgcgcgtcac ggacgagggg caggaccgcg 20460
cgggcgacca cagggtcgcc gtggtcggca tggcctgccg cctgcccggc gcgcccgggc 20520
tcgacgcgta ctgggagctg ctgtcccagg gccgccgcgc cgtgcgcgag gtgcccgccg 20580
agcgctgggg gcgggccacc ggcttccgcg ccgggctcgt cgacgacgtg tacggcttcg 20640
acgccgggca cttcatgctg cacgccgagg acgtccgcgc catggacccg caggccctgg 20700
tcctcctgga ggagagcctc aaggccgtgc accacgccgg ttaccgggcg gccgacctgg 20760
agggctcgcg caccggcgtg tacgtgggcg cccgcagcgg gcagcggccc gacggcacgc 20820
tggtggacgg ggcccgcaac cccatcatga ccgtgggcca gaactacctg gcggccaacg 20880
tctcccagtt cttcgactgg cacggccccg ccatggtcat ggacaccgcc tgctcgtccg 20940
cgctcacggc gatgaaggtc gccaccgacg cgctggccgc gggctccgtc gacctggccc 21000
tggtcgcggg cgtcagcctg ctcgccgacc ccgaggcgca cgagctgttc cggcgccgcg 21060
gactgctgcg tgaggacggc gcgttccaca tcttcgaccg ccgcgcgggc ggcgtcgtcc 21120
tcggcgaggg cgcgggcgtg gtgctgctca agccgctggc cgccgccgag cgcgacggcg 21180
acaccgtgta cgccgtcgtc gaaggcctcg ccgtcaacaa cgacggccgc acggcaggac 21240
ccgccacgcc caacctcacc gcccagaagc aggtgatgcg ggaggcgctg cgccaggccg 21300
gctgcccccc gcaccaggtg ggccacctgg acgtcaacgg ctccggatcc gaactcacgg 21360
acctcctgga gctgaaggcc gtccaggagg tgtacggagc ggaccgcacc gcgcccctgc 21420
acgtcgggtc gatgaagccc aacatcgggc acccgctgtg cgccgagggc atcgccgcct 21480
tcatcaaggt ggcgctgatg gtgcaccacc agcggaccgt gccgttcctc tcgggcgagc 21540
agcccatgga gcactacacg atcgaccccg ccgtactcca cctgccccgg cacgccgagc 21600
cggtggacct ggcgtacgcg gcggtgagca gcttcgccga cggcggcacg aacgggcacg 21660
tcgtcctggg ccgccccgat gcgccccgcc ccggcaggga acagcggggc cccgtgccgc 21720
tcccggagct cgaccgccgc gacgtgcgca ccgacgcacc cgtccgcgcc ggcgagcccg 21780
aggccgccac cggggcacgg gtgtggacgc ggcgcgtcga cgcccgcgac gccgtcgtgg 21840
acggacaccg cgtctacgga cggcggctgc tgcccggcct cgcctggatc gacctcctgt 21900
acggctgctg cgccgacctc gcaccggacg cgtcccccgc ccggctcgcg ctgcgcgacc 21960
tgtcgatcta ccggccgctc gccgtggacg agggcgccgc cgtggacctt cgtatcgagg 22020
cgcgcgccac ggccgcggac acctggcaca tcactgtcac cgacgcggcg cgcggcgaga 22080
ccccggcacc gtacgtgacg gccgacgtgc acctcacgga cggcgccacc gccttcgacg 22140
cggcagttcc tgccgacgtc ctgcgcaccc gtggcgaggg ggcgcgcgac ctcggcgaga 22200
tctaccggag cttccgctcg caggagctcg tgcactcggg cgagatgaag gtcgtcggct 22260
cggtgcgcac cacgtccgac gacatctggg tgagcgtggc cgtcgacgag tccgccgtat 22320
cgagtggggc ggtagagcgt tcgttccacc cggcattgat cgacggcagc gcggtggcgg 22380
ccagcgccgt cgccctgggc ggcgagccgc ggctcttcct gcccctgcac tacgcctcgt 22440
tccgggccgc cgcgccgctg ggccgcgcct gccacacgcg cgtgcggcgc agcgggatca 22500
cccgcgggga cgaactcctc accttcggaa tggagttcta cgacgaccgc gggcgcaagc 22560
tgggcgagct gaccgggctc accaccaagg cggtgcgcga cgccgggcac atcgaccccg 22620
cgcgggccac cgcgccgaag cccgaggccg cgccggtgga aaggaccgcg cccgtggccg 22680
ccgctccggc cgtcgccgct ccggccgccg ccgctccggc tgtcgacgcg atgcggacgc 22740
tcgtacggtc cgtcgtcgcc ggtcgcctcg gcgtgcccga ggaccggatc gacgcggacg 22800
cgagctacta cgcgctcggc ctggactccg cgacgctgct gcggatcgcg gcggagctgg 22860
gggagcggct cggcacgaaa ctcgcgccga cgctgctgtt cgagcacgcc tcggtggcgg 22920
cgctcgccgg gcacctggcc cgccaccacg agcctgcggc accggccgag gcgtctggcg 22980
tacccgcgca cgccgaggcg ccgcgccccg tcgcggcccc ggccgccacg gaagccgccg 23040
gtgccgtcgg ttccgtcggt gccgtcggtc aggacatcgc gatcgtcggc atcagcggcc 23100
ggtacccgaa ggcgcgcggc ctcgccgagt tctgggagaa cctcaagtcc gggcgcgact 23160
gcgtcggcga ggtgcccgag gagcgctggc cgggcgacac cttcgacggc gagcgcaccc 23220
cgtcggggcg gccggtgtcc cgcctcggcg gcttcctcga cgaccccgac tgcttcgacg 23280
cggagttctt ccagatatcc gacgccgagg cggcccgact cgacccgcag gagcggctgt 23340
tcctcgaagt gtgctgggag gccgtcgagg acgccggata cacgcccgcg ggcctctccg 23400
cggccgacgg cggacggcgc ggggccgtcg gcgtcttcgc cggggtcatg cacaaggact 23460
acgtcctggt gcagcacgac gcggcggacg gcgacccggc cgtcccgccc gcgcccctgg 23520
cgctgaacgc cgcggccatc gccaaccgcg tctcgcactt ctgcgacttc cgcggcccgt 23580
ccctcgcggt cgactccgtg tgcgcctcgt cgctgagcgc cgtgcacctg gcggtggaga 23640
gcctgcggcg cggcgagtgc gacgccgccc tcgcgggcgg tgtgaacctc tcgctgcacc 23700
ccgcgaagta ccgcacgtac ggcagcctcg acctgctggc gggcgagacg ccctcccgct 23760
ccttcggcgc cgggggcgac ggctacgtgg ccgcggaggg cgtcggagcc gtgctcctga 23820
agcccctcga ccgcgcgctg gccgacggtg acgccgtgta cgccgtcatc aagggcaccg 23880
ccgtcaacca ctcgggccgg acccccggca tgcgggtgcc gtccgtcgcc gcgcaggcgg 23940
agctcatcga gacctgcctg gagcgcgccg gggtcgacgc cgggacgatc ggctacctcg 24000
aagcccacgg cacgggcacg gagatcggcg acctcatcga agtgcagggg ctgcgccggg 24060
cgttcgagaa gcgcacggac gccaagggct tctgcgccct cggctcggtc aagtccgcca 24120
tcggccacgc cgaggcggcc gccgggatca gcgggctcac caaggccgtc ctccagctcc 24180
accaccggac cctgacgccg ctggtcggcg gcgccgggac caacccgtac ctcgacctcg 24240
ccgactcgcc gttccggctc cagacggacc tcgcggagtg gacggtggac gcgggctgcc 24300
ccggcacgcc gcgccgcgcc ggagtgagcg cgttcggcgc cacgggcacc aacgcccacg 24360
tcgtcgtcga ggaagcaccc ccggtgcgcg accacgccct gagcggcgac gcggcgggcc 24420
ccgtgctcgt accgctgtcg gcgaccgacg gcgaccggct gcgcgcctac gcggacaagc 24480
tgctgcgctt cctcgacacc aaggagggcg ccgcgctcga cccggccgac ctggcccaca 24540
ccctccagac cgggcgcgtc gccctggccg agcgcgcggt gatcctcgcg cacgacctgg 24600
acgaggtccg cgagggcctg gaggccgtgg ccaacggcac cgggaccgac ggcaccgggg 24660
tccgggtgtg gcgcgggcgc gtggcggaga cacccgcgga ggcacggctc ctcgacgagg 24720
acgacgtacg cgcggaactc gtcggccgat gggcggcgcg gggcaagtgg gccaagatcg 24780
cggagctgtg gctcggcggc tacgccctcg actggcccgc cccgcacggc acggcggccc 24840
cgcgccgcgc gcacctgccc acgtacccgt tcgccaagcg gcgtcactgg atcacggcac 24900
cggcaccggc accgggaacg gccggcacgg cacccaccgc gcaggccccc gcttccgaga 24960
gcggcaccgt ccactggcac ttcgtgcccg acggcgcgca gccgcccgcg tccgcccacc 25020
gggccgacct cccggcggag gagaaggccc gcggctacgt gcgccagctc gtcgccgccc 25080
gcgtgggacg ccccgcacgg gacatcggcc cgcacgcggg tctgatcgac atcggcctga 25140
cgtcgctcgg cgccgtcggc ctcagcaagg acctggcggc gacggtcgcg cccggcttcg 25200
tgcccagcgc cctgttcgag tacggcaccg tcgccgaact cgccgggtac ctgacggcca 25260
cgtggcccgc gggcccggcc cgtcttgtcg ccacgcgccc gcaggccccg gagccggacc 25320
tgccgtccgc ccggccggag gaacggccca ccgcgcccga cgtcctggac gtcctcgagt 25380
gcctgcgcag cggcgccctg cacctcgacg acgccatcgc gctcctcgac gaagagagtt 25440
acgagaagtg aagcacgagc tcagcgccct catcgcggac tacaaggcgg gcaaggtcag 25500
cgcccgtgag gtcggcgacc tcctgcgcga cctgcgcgag caggcggggg agccgcagcc 25560
cgccggggcg ttcgcgtacc cgctctccga gggccagcgc ggactgtggg cgctccagcg 25620
ggcgtacccg gacatggccg cgtacaacgt gccgctgtgc ttccgcgtca gcggcctgga 25680
cgtggcggcg ttccaggacg cctgccgggc gctgctcgtg cgccaccccg tgctcaccac 25740
cgtgatcggc caggacgcgg gcgagccgac gcagtccgtc gaccccgccc gcgcgctcga 25800
cttcgcgcgg atcgacctga cgggcaccgc cgacgagggc gaggcgctcg ccgccgtgga 25860
gcgcgcgggc aagcgggtgt tctccctggg cggggcggcc gggcacgagg gcgaaggcct 25920
gttccgcgtc cgcgtcttcg accgcccggc gggcgagtcg ctcgtcctgg tcgtcgtcca 25980
ccacatcgtc ttcgacggca cgtcggcgac gctcctgatg agcacgctgt tcgaggagta 26040
cgaggcgcgg gtgagcggcg taccggcgaa gggccgcgac cccgaggaca ccgcgggctt 26100
ccacgacttc gtccgcgagg agcggcgcac cctggccgcg cgcggcgccg agcgccttcc 26160
ctactggcgc aaccggctcg ccgcgcccct gcccgtcctc gacctgcccg cggaccggcc 26220
gcacacggac ctcgccgacc gcttcgccgg gaagacgctc gtgaccgagg tgcccgcgga 26280
actggccgcg cgcgtcgccg agttcgccac cgcgcggcgg accttcgtgt ccacggccat 26340
gctcaccgcc tacgcggcga ccctggcgac gtactccgac gccggtgaag tcgtcgtcgg 26400
catgcccgtg aacgagcgcg aaggcgacgc cctcgcccgg accgtgggcc tgatgatcaa 26460
catggtgccg gtccgcgtcg cgctcccgcc cgacgagccc ttcgaccggc tcgtcacgcg 26520
cgcccagcgg gacgtcgccg acgacctgct gcacggccac cccttcccgg ccctcgtgcg 26580
ggacctcgcg caggacaccc cggccgggcg ctccccggtg ttccagacgg cgttcgtctt 26640
ccaggacgtc ctcgacggca tcgccgacgc cgaccggccc taccggctcg tcgaggagct 26700
gcaccaggaa ggggagtacg agctctccgt cgaggtgtgg cgcagcggcg cgggctacgc 26760
gctgtactgg aagtaccagc cggagctcta cagccgcgcg ttcatccagg agctggcggc 26820
ccgcttcgcc gacgtcctgg cggcggtgtg cgacgagccg cacacgaccg tggccgccct 26880
gcggcagcgc ggcgccgagc ggtgcgtgca ggacctcgtc gaggacacgg cgcggcgcac 26940
cccggacgcg gtcgccgtgg ccggtcagga agaggtcctg acgtacgagg cgctcagcgc 27000
ccgcagtgcc gcgctcgcct cctgcctggt ggcgcggggc gtgcgccgcg gcgacctggt 27060
gtccgtgctg ctcgaccggt cgcccgacct cgtcgtgacc ctgctcggca tcctcaaggc 27120
gggcgcggcg tacgtcccgc tcgacccgga gctgcccgcc gcccggctca cggacatcgt 27180
gacggacagc ggcaccccgc tgatcgtgac ccagacccgg cacgaggccc gcgcccgcgg 27240
cctcgcggag ggccgggggg ccgccgcgcc cgcgctgttc gtactcgacg aggagcggga 27300
cgcgctcgcg gccgccctcg ccccggggcg gtccgccgcc gtgcccgtga ccgccgacga 27360
cctggcgtat gtcatctaca cgtcgggcag caccggccgc cccaagggcg tgatgatccc 27420
gcaccggggc ttcaccaacc tgctcggctc gctgcgccgc gagcccggca tggacgcgac 27480
ggacaccctc ttcgccgtca ccaccgtcag cttcgacatg gcgcaggtcg aactgctgct 27540
gccgctggtg tgcggggccc gcgtctatgt ctgcgacagc ccggccatca aggacgtgga 27600
ccggctcaag gagcgcatcg cccgggtgcg gcccacggtg atgcaggcga ccccggcgac 27660
gtggagcatg ctgttccact cgggctggcg caaccccgag ggcgtgcgga tcttctgcgg 27720
cggcgaggcg ctgccccgca cgctcaagga gttcttccgc gacaccggca ccgaggcctg 27780
gaacctgtac gggccgaccg agacgaccgt gtactccacc ggcggcctcg tccgccacga 27840
ccggccgacc accatcggca ggccggtcgc ccacacccgg gtccacatcc tcgacgagca 27900
cctgcgcccg gtgccccacg gagagaccgg cgaactgtgc atcgcgggca agggcctggc 27960
gaagggctac gtcaaccggc ccgacctcac cgcggagaag ttcgtcgacc acgacctggt 28020
gcccggcggc aagctctacc gcaccgggga cctggcccgc tggaccgagg acggcgagat 28080
cgactacctg ggccggaagg acttccaggt gaagatccgc ggctaccgca tcgaactggg 28140
cgacatcgag taccacttgg gccgccacca ggacgtcgcc gagtgcgtcg tcgtcgcgcg 28200
cggcgaggac ggcgccaagc agctcgtcgc ctactacgtg ccgggcggcg cgggcgcccg 28260
ccccgacgcc ttcaaggaac acctgcgcgc gctgctgccc gcgtacatgg ttccggactt 28320
ctacgtcccg ctcgacgccg ttccgctgac gggcagcggc aaggtggacc gcaccgccct 28380
gatggggcgc gaggtgtccg ccgccgcgcc cgccccggct gcccgccccc agcgggccgc 28440
gcggccctcc cgtgacgtgg agcgcgaggt cctcgcctgc tggcaggagg tcctgaaggt 28500
gcgggacctc accccgtccg tctccttctt cgagtccggc ggcaactcgc tgtcggccgt 28560
ggtgctcgcg gacctgatcg gccgccggct cggggtgtcg ttcgcggcgg ccgacctgtt 28620
caagtacgcc accccggccg ctgtcgccgc gtacgtgcgg gagcaggtgc cggaccaggc 28680
ggaggcggcc caggaggcgc cggagcccgt cgcgcccgct cccgcgcaga cgcagacgca 28740
gacgcaggct ccggagccgg agccggagcg cgtgtccctg cccgacgacg ccgtcgccgt 28800
cgtcggcatc tcctgccgct tccccgacgc ccgcgaccac tgggagttct gggagaacct 28860
caagcgcggc cacgcctccg cagggcgctg gagcgaggcg gagctgcgcg ctgcgggcgt 28920
gcccgaacgc gtcctgcgcg acccggactt cgtgccgctg cgctcggggc tcgacggcaa 28980
ggacgagttc gacggcgcgt tcttccggct ctcgccccag cacgtcgagc tgatggaccc 29040
gcagttccgc caggtcctgc tgcacgcctg gaaggccgtc gaggacgcgg gccgcgacca 29100
ccgggagatc cccaacaccg gggtgtacgt ctccaccggc aaccaccact acggcgcccc 29160
ggacgacacc gccgagacgc ccgccgcggt catcgaggac ccgcggcagt acctgtcgtg 29220
ggtgatgagc cagagcggca ccgtcgcctc catggtctcc taccagctcg gcttcggcgg 29280
cccgagcatg tccgtgcact ccaactgctc gtcctcgctg agcgccctcg ccctcgcggc 29340
ccgcgccgtg cagaccggcg agacggactt cgccctggtg gcgggggcct ccgcgaacag 29400
cgtcgacggg ctcggctacg tccacaaggc gggcctcaac ctctccggcg acggccgcgt 29460
caaggccttc gacgcggacg ccgacggcat ggcgggcggc gagggcgtcg tggccctgct 29520
gatccgccgc gctgccgacg ccgtcgccga cggcgaccac atctacggac tgctgcgcgg 29580
catcgccgtc aacaacgacg gcggcgacgc caccggcttc tacagcccca gcgtcaacgg 29640
ccagtcccgg ctgatccggc aggtcctcga ccgcaccggc gtcgacccgc gcaccatcgg 29700
ctacgtcgag gcgcacggca ccggcacgaa gctcggcgac cccgtggagg tcgccgcgct 29760
caccgaggcg taccgcgcgt tcaccgacga caccggctac tgcggcatcg gctcggtgaa 29820
gaccaacctc ggccacctcg acaccgcggc cggactcgcc ggtgccgtca aggtgctcct 29880
gagcctctac cacgggcagc tcccgcccac gctccactac cgcgagccca acccccaact 29940
gcgcctggac acctcgccgt tccacgtcgt ggaccggctg cgcgactggc ccgcggacgg 30000
cgggccgcgc cgcgcggcgc agagctccat cggcctgggc ggcaccaacg cccacgccgt 30060
cttcgaggag tacgtccccg ccgccccggc acgcgccgac gacgagggcg ccccgcagct 30120
ggtgccgctg tccgcccgca cccgcgacga cctcgtgcgc gcggccgccg agctgcgccg 30180
gcacctgacc gggccgcgcg ccgccgcgct gcgcctggac gacgtcgcgc acacgctgcg 30240
caccggccgg gtcgccctgg cccaccgcgt ggcgttcgtc gtgcgcgacc tggaccggct 30300
ggccgccgaa ctggacgcgt tcgtacggga cccggaaggc gacgacaccg cgcgccgctt 30360
cacaggccct gcggcgggct gcgccacggc cgacgccgac gccacccgca agcacaccgc 30420
gcagctcgcc cgcaggctcg ccgacggcaa gctgaagaag gccgcgaagg cctgggcgcg 30480
cggcgccgag gccgactgga gcccgctcgc cgggcagcgg cccgcccgcc gcgtgagcct 30540
gcccggatac gccttcgcgc cggtggtcca cccgtacccg gtccgcgcgc cgcggcccgc 30600
caccgccgcg ccccgcccgg acgcggcccc cggcacgccg ctcgcgcacc cgctgctgca 30660
cgagaacgtg tcgcggctcg acggacagcg ctaccgctcg tccttctccg gcgccgagtt 30720
cgtcctgcac gaccacgtcg tcgacggcaa gaagctgctg cccgccgtcg cgagcctgga 30780
gatggcctgc acggccgtgc ggcaggccct gccggagacg gccgggcggc gcaccgtcct 30840
gaagaacgtg acgtgggcgc gcccggtcgt cgtggacgac ggcggcaggc aggtggagtt 30900
caccctcacc cgcgacgaga cggccccctc cgggccgctg ggcttcgccc tcctgacgga 30960
cggcgaccag ctgtgcgtcc agggccgcgc caccatcgac gcggccgcgc cgccgccccg 31020
cgtcgacctc gcggacctgc gcgaccggct gcgcctgcgg cccctcgcgg gcgaggacgt 31080
gtacgcgcac atcgcccgcg cgggcgtcgc ctacggcccc ggcttccgcc tcgtgcacgt 31140
gctgcaccgg ggcgagcgcg acgggcgccg cgaggtgctc gccgaactgc ggctgcccgc 31200
gcacctgcgc gccacggcgg acgcgtacgc gctccacccc agcttcctcg acgccgccgt 31260
gcacgcttcg ctcggcctgg acccggcctt cgactccgcc gcggccggga cggtcgcgga 31320
cgggacgacg cgggtgccgt tcgcgctcga ccggctcgac gcgcacgcgc cgttcggcga 31380
gacgatgtac gcctgggtgc gcccggcggc gaaccgttcc gccgcggcgg aacgcgtcct 31440
cgacatcgac ctcctcgacc cggcggggca ggtctgcgcc acgctgcgcg gcctcgccta 31500
ccgcgccctg gccacgcccg accgccggga gcccgagagc agggagtccg agcgccggga 31560
gcccgagagc cgggagtccg agcgccgccc ggaggcgact cgcgcctccc ggctgcgcac 31620
gctgcttccg gtgtgggagc cccggcaccc cgccgaggcc ccggccccgc agagccctcg 31680
gggcgccgtg ctcgtcctgg acgccgaccg caggctgcac gccgaactgg cggtgctcca 31740
cccgggccac cagcgcgtcg acctgcctga tggcgcgtcc gccgacgaca tcgcggggct 31800
gatccgcacc gcctgcgcgg ccaccggcgg gcggatcgcc cggatcgtct gggtcgcccc 31860
cgccgagacc cccgacggca tggtccgggg ccaggagcgc ggcgcggtcc aggtcttccg 31920
cgtcgtcaag gctctactcg ccctcggcca cggcacgcgc gacctcgcct ggtccctcta 31980
cacgttcggc acccaggccg tccgcgaccc cgacccggtc gcggccacgc acgcgagcgt 32040
ccacggcctg gcgggcagcc tcgcccagga gcacacgcgc tggacgatcg acctcgtcga 32100
cctgccgcac ccggactccg gcgacctcgt cggcgaccgc ctcggcgagg agcgacgcct 32160
caccggggtg cgccccggca ccacggtggc cctgcgcggc ggccgctggt tctcccacga 32220
actgctgccc accaccgccc tggaaccggc caccggcacc taccggcacg gcggcgtcta 32280
cgtcgtcatc ggcggcgcgg gcggcatcgg cgagctgtgg agccggtaca tggtcgaccg 32340
ctaccgcgcg acgatcgtgt ggatcgggcg gcgccccctg gccgacgggg tggagcggcg 32400
cctcgccgac ctcgccgagc gggcccgcgc cgcgggcgcg gcggccccct cgtacgttca 32460
ggccgacgcg cgcgacgacg agagcctgcg ggccgcgcac gcgcggatca agcgggacca 32520
cccgcgcgtc gacggcgtcg tgcactccgc gatcgtcctc gccgacaaga ccctcgcgca 32580
catggacgag gaccggttcc gcgccgccct cgccgcgaag gccgacgtcg gcgtccgcgt 32640
cgccgacgtg ttcggggccg agccgctgga cttcctgctg ttcttctcct cggtcgagag 32700
cttcgtccgg gcccccggac aggccaacta cgccgccgga tgcaccttca aggacgccct 32760
cgcgcacgcc ctgaaccggc gcggcaccac cgtcgccaag gcggtcaact gggggtactg 32820
gggcgtggcc ggtgtcgtca gcgactcctt ctaccgcgag cggatggccg ccgccggagt 32880
cgactcgctc gaccccgacg aggcgttcac cgccctggag tccttcctcg cgggcgagca 32940
cggccaggtc gccctgatgc gcaccttcgg cgacgaggcg ctgcgcggcc tcgccctgga 33000
cgaacaccag ggccgccacc gccgcgcgct gccctccgtg cgcgacgccg tcgtgtccgc 33060
gcaccgcgcg ccgcacggcg aggtcgagcg gctgcgccgc ttcctgccgc acccgcgcat 33120
gcgcgaactc accctgaacc tgctgtacgt gaccctccgc gacctcggcg ccgcgcgccc 33180
ggacggggcc gggcacggcg tcctgccccg gtacgcgcgc tggctggagg agagccaccg 33240
gctgttcgcc gaggccggcc ccgccctcgc cgccctggac ctggacggcg ccgccctgtg 33300
gcgccagtgg cgggccgagc gcgacggctg gcagacaggc gccaaccagc gcgcgcaggt 33360
cgacctggtc gagtcctgcc tccaggccct gccggacgtc ctcaccggcg tccgccaggg 33420
caccgagatc ctcttccccg gctcctcgct gtcccgcgtc gagggcgtct accggggcga 33480
cccggtcgtc gactacttca acgaccggct cagcatgctc ctcgccgacg ccgtgcgcgc 33540
ctggggcacg gccgagccgg gccggcggct gcgcgtcctg gaggtcggcg cggggaccgg 33600
cgcgaccagc gtcaaggtcc tggaggccct cgaaccgttc ggcgaccgca tcgccgagta 33660
ccactacacc gacctgtcca aggcgttcct gttccgcgcc gaggaacgcc tcaagccccg 33720
ctacccgcac gtgaccaccg gcatcttcaa cgccgagcac gcgcccgggc cgcagggcgt 33780
cgacctcggc ggcttcgacg tcgtcgtggc caccaacgtc ctgcacgcca ccgccgacat 33840
ctcccgcacc ctgcgcaacg tcaaggcgac cctgcgggag ggcggcctgc tcctgctcaa 33900
cgagatgagc cgcaacaccc tgctcgccca cgtcacgttc ggcctcgtgg acggctggtg 33960
gctgtaccgg gacgccgccc tgcgcatccc cggcagcccg gtgctctccg ccgagagctg 34020
gcgcgaggtc ctggaggacg aagggttccg caccggtgcc cagccggaca ccgaggccca 34080
cgcgctcggg cagatgctgc tcgtcgcgga gagcgacgga cggtaccgca cgccggacgg 34140
cccgagcgcc gctcaggacc aggccgcgcc ccgcaccacc gcccccgcgt acgagcccgt 34200
cgcggcggcg cccggcgcgg acgacgaggg cgagctgcgc gcgcgtaccg ccgactactt 34260
cgagcggctg ctgcgcgagg ccctgcacct ggcggacggg gagctcgacc cggccaagga 34320
cctgcacgac tacggcctcg actccatcct cgtgtccggc atgaacagcg ccgtggcccg 34380
ggacttcgag gacgtcagca gcaccctgtt cttcgaactg cgcaccctgg acgagctcgt 34440
ggaccacttc gtggagcggc ggcgcccgga gctgcggacg ctcttcggcc tcgaccgggc 34500
ggacgcccgc agcccgcagg ccgacgccgc ccgggcctcc gacgcgtccc tcgccgagag 34560
ggccgtcgcg tacctcaccg gcctcgtcgc cgagacgctg aagctcgacc cggagcggct 34620
cgacgcggac gccgacctct tcgacctcgg cctcgactcc atcctcgtcg tccagctgaa 34680
caacaccctc ggccgcgact tcgaggacct cggcagcacg ctgttcttcg accactcgac 34740
ggtccgggac gtggccgcgt acttcgcgac gacgcacgcg gcgcggctgg ccgaggtcct 34800
gggcacggcg acccccgcgg caccgccgac ggaagccacc cgtccggcac ctctgaccgc 34860
tgcggtcgag cccgcccccg cccccgcccc ggctcccgag gtccggcccc ggcccgagcc 34920
gcactccggc gacatcgccg tcgtgggcct cgccgggcgc tacccgggcg ccgagagccc 34980
cgcccgcctg tgggagaacc tggcccgcgg cgagagtgcg accgcgccct acccggccga 35040
ccgctggtgg tgcgactggc aggaccggga gcgcccctgg ggcggcttcc tcgacgacgt 35100
ggcctccttc gacgccgcgt acttcggcat cgacgagcgc gaggccgcgg ccatggaccc 35160
gcaggagcgg ctgttcatcg agaccgcgca cggagccgtg caggacgcgg gctacacgcc 35220
cgcggccctc gccggacacg gccgcgtcgg cgtgttcgtg ggcgtcatga acgccacgta 35280
caacgggcgc acggcctact cgtccatcgc caaccgcacc tcctacctct tcgacttcca 35340
gggcccgagc gtggccgtcg acacggcctg ctccgggtcg ctcacggccc tgcacctggc 35400
cgtgcagagc ctgctctccg gggacagcgc ctgcgcggtg gcgggcggcg tcaacctgct 35460
cctcggcacg gaccacttcg acgtgctcca ggagcacggc ctgctgtcgt caggggagcg 35520
gtgccgcccc ttctccgagc acgcggacgg cttcctcgcg gcggagggtg tcggcgccgt 35580
ggtgctgcgc ccgctgcgcg acgcgctggc cgcgggcgac cacgtctacg gcgtgatcaa 35640
gggaagtgcc gtcaactccg gcggccgcac cagccgttac agcatgccga gcctggacgc 35700
gcagcgcgac gtcgtcaccc acgccctggc cagggccggg gtcacgccgg acacgatcag 35760
ctacgtggag gcccacggca cggcgacgcc cctcggcgac tccctggaga tctccgcgct 35820
cagccgcgcc ttcgccggtg accgcccggg gcagtactgc gcggtcggct cgctcaagtc 35880
caacctgggc cactgcgaga gcgcctcggg catcgcgggc ctcaccaagg tcctgatgca 35940
gctgcgccac cgcgcgctcg cgccctcgat caacgccgag gacctcaaca ccggcatcgt 36000
cttcaagcag tcgccgttcc acgtccagcg cgagctcgcc ccctggcacc cggtcgacgc 36060
cgaagggcgc cccctgccgc ggcgcgcggg catctcctgc ttcggcgcgg gcggctcgaa 36120
cgcacacctg atcatcgagg gatacgagaa catggccgac gacgaggccc gcaccgccga 36180
tgcgacggcc gacgagacct gcctggtccc gctgtcggcg cacacgcccg agcaactgcg 36240
cacggcggcc gggcagctgg ccgcgcacct gggcgaggcg gagcgcgagc ggcgcccggt 36300
gccgctgcgc gacctcgcgc acaccctcca gaccggccgc gacgaactgc ccgtgcgcct 36360
cgcgctcgtc gtccgctcca ccgccgaact cgccgcagcg ctggccgagt tcagcgcaca 36420
cggcgtcgcg ggacccggcc ggtacgccga cctcaccgaa tccggcaccg gcaccggtgc 36480
acgggtgtcg gcggtgggcg gcgcggccgg tgacccgcac gcggcggcgc gcggctggct 36540
ggccggagcg agcgtcgcgt gggccgagct gcacgccggg cgcccgccgc gccgcgtcag 36600
cctgccgacg tacccgttcg cacggcgcga gtactggtac gagcctgcgg gggagcggcc 36660
ccaggccggg gagcgcgcgt ccggcacccc ggtagcggca cgccccgcac cgcaccccgc 36720
accgcgcgcc gaggacggcg cccacgacgt ccgggcctgg ctgcgcgccg cgctcgccga 36780
ggagctggac ggcgtcgcgc cccacgacgt cgccaccgac cgcgagttcg ccgcgctcgg 36840
cgtctcgtcg atgggcctgg tgcggctctc ccggcgggtg cggagcgagc tgcacgcgga 36900
cttcgcgtcg gccgcgctct tcgagcaccg caccgtcgac gccctggccg cccacctcgt 36960
cggcgtactc ccgcaggtgg ttcacacccc cgatgcggtc gacgcgttcg tgccgcaccc 37020
gctgtccgag gggcagcggg gcctgtggag cctccagaag tccgcacccg acgcgagcgt 37080
gtacaacgtg ccgctgtgct tccaggtgtc cggcctcgac ctgccggccc tgcgcaccgc 37140
cttcgaccgg gtccgcaccc gccacccgct gctggcggcc gtcgtacgac gggacggcga 37200
ccgcctcgtg ttcgcacggg ccgaggcccc gcggcccgcg gtcaccgagc acgaactgac 37260
cgcgacggac cccgacgagg tgcgcgcaca gctgcgcgcg cacgccaaag agccgttcga 37320
cctggagaac ggcccgctgt gccggctgag cgtcttccac ggcgctccgg gcgcggacgc 37380
ccgggtgctc ctgaacgccc accacctcgt cctcgacggc gcctccgccg tcgtgctcgt 37440
caaggacctg ctggccgcct accggagcgc cgccgcgggc gccgcgccgg ttccggccgc 37500
cgcggccgcc ccgtacgccg agttcgtcgc cgacgaggcc gctctccagg ccggggacga 37560
gggcgcggac cggctcgcct tctggcgcga gcagctggcc gcgctgccgc ccgtccccgc 37620
cttccccacg gaccggccgc gctccgcgcc cgaccagggg cggcacggcg ccaccgaggt 37680
cctgcggctc ccggtggacc tcggcgaccg cgtcgcccgg ttcgcccgcg agcggggcgt 37740
ctacccgtcc gccgtgttcc tggccgcgca ccaggtcctg ctgcggcagt acgcccagca 37800
ggacgacgtc gtcgtcggca tgccggtcag cacccggccc ggcgcccgct tcgacggcac 37860
cgtcggccac ttcgtcacca tggtgccggt ccggacccgg atgtcggggc gcggcacgtt 37920
cgccgagctg tgcgcggacg tccagggcac gctgctggac gccctcgcgc acgcctaccc 37980
gttcggcccg ctggtccgcg agctcggcct gggcacggcc gacggctccg cgccggtgtt 38040
ccgccacgcc ttcatgtacc aggactggca cgaggacgtc accgcgggag cccccggcgt 38100
ccgctacgtc gagggcgtcc accaggaggg cgagtacgaa ctcgtcgtcg aggtcatcgc 38160
gccgcacgcc accgaggacg cgtacaccgt caaggcgaag tacgaccccg ccctgttcga 38220
cgccgcgacg gtggaccggc tgctgcgcca gtacgcccac ctcctggagt cggccccggg 38280
cacggacccg ctccggcggc tcgacgactg ctcggcggcc tcgccgcagg agctgcacac 38340
cctcaccgtg gagtggaacg acaccgccgt cacccagccg gacaagcacg tccacgagct 38400
gttcgccgag caggcggccc gcacccccga cgcgatcgcg ctcgtggcgg gcaccgagtc 38460
cgtgacgtac gcgcgactgg acgagcgcac ccgggagctg gccgcgcgcc tgcgccgaac 38520
cggcgtggga ccgggccgtc tcgtcgccgt ccacctggag cgctccgtcg acctcgtcgt 38580
cgcgctgctc gccaccctgc gcgccggggg cgcctacatc cccctcgacc cggactaccc 38640
gcgcgaccgg atcgcccaca tcctcgacga cgcagggccc gccgtcctgc tcagccacac 38700
cgcgctgcgc ggacgcctcg cggacctggc ggttccggcc ggtcggcgcc tgctcgtgct 38760
cgacgacccg gacgccgacc cggcggccgc ggagccgagc ggcgccgcgc ccggcgcgca 38820
ggatccggcc tacgtcatct acacctccgg cagcacgggc ctgccgaagg gcgtcgtggt 38880
gccccaccgc gcgctcacca acttcctgtg cgcgatggcg aagcggccgg gcctcggcgc 38940
ggccgaccgc gtcctcgcgg tgacgacgca cagcttcgac atcgccgccc tggagctcta 39000
tctgccgctc gtcaccggcg ccgagtgcca cctcagcgac ccggagaccg cgcgctccgg 39060
cgaccggctc gccgcgctcg tcgcgcgggt gcggcccacc gtgatgcagg cgacccccgc 39120
cacctggacg atgctgctgc acgcgggctg gaccaacgcc gaaggcctgc gcgtgctgtg 39180
cggcggcgag gcgctgtccg agtccctcgc ggagcgcctc accgccctgg gcggcgaggt 39240
gtggaacctg ttcgggccca ccgagaccac cgtgtggtcc acggtcgccc gggtggaggc 39300
gggccgccgc gtcaccatcg ggcgccccat cgacaacacc cggatccaca tcctcgacaa 39360
gcgcggcgcc acggccccgg tcggcgtgcc cggcgagctg tgcatcgcgg gcgacgggct 39420
cgcgctcggc tacctcaaca agcccgagct caccgccgag cggttccccg ccgacccctt 39480
cacgccgggc ggcaggctgt accgcacggg cgacctggca cggcgccgcg cggacggcgc 39540
catcgagtgc ctgggacgga tcgactccca ggtgaaggtg cgcggcttcc gcgtcgagcc 39600
gggcgagatc gagcacgccc tcacccggca ccccgccgtg cgcgagtgcg ccgtcgtcac 39660
cagggccgag cccgcgacgg gcgccaccca gctcgtcgcc tactggaccg gcggcaacgc 39720
caccgcgcgc gagctgaccg agcacctgcg ccgggccctg cccgcgtaca tggtgcccgc 39780
gttcgtcctg ccggtcgacg cgctgccgca gaccccgaac ggcaaggtgg accggctcgc 39840
cctggcccgc cggccgatca cgctgccgga cgcgcccgcc ccggagcgga gcccggctcc 39900
gccgaccgcc gtcggcaccg tccgcgacag cgacgtgctc gccgtgtggc gggacgtgct 39960
cggcgtcgcc gggctccgcc ccacggacgc cttcctggac gcgggcggca actccgtcct 40020
cgcggtggtg ctcgccgacc gcgtcgccga gcgcttcggc gtgcgcttca cctcggcgga 40080
cgtcttcggc tgcgtcgacg cggccggtac ggcagcccgg ctgcgcgcgg acctcggcgc 40140
ggcgcaccgg ccgggcgacg acgcggcccc ggccgccgac accccgtcgg ccgatggcgc 40200
gccccgtgcc acggccccgg ccgcgccgga gccgtccggc cggctcgacg gcgccgtcgc 40260
cgtcatcggc gtctccgtcg ggctccccgg cgccgacgac caccgcgcgt tctggcgcaa 40320
cctcgtcgcg ggcacggaga gcgtggagct gtgcacccct gacgagctgc gccgcatcgg 40380
cgtcgacgaa ggcctggtcc aggacccggc gcacgtgccg gtccgcgcga gcatgcgcgg 40440
caagggcctg ttcgaccacg ccttcttcca ggtctcggcg cgcgacgccg aactcatgga 40500
cccgcaggcc cgccagctgc tccagcacgc ctggaaggcc gtcgaggacg ccgcgtacct 40560
gcccgccgac atcgccgacg cggcggtgta catgtccacc gccaactccc tctaccaggc 40620
gcccgtcacc ggccccggcg cccgccgcga ctcggaggcc ctcgtcggct tcctccaggc 40680
gcagcccggc accgtgccga cgaccgtgtc gcaccggctc ggcctgcgcg gaccgagcct 40740
gttcgtgcac agcaactgct cgtcggcgct cgccggcctc gccctggcct gccagggcat 40800
ccagtcgggc cagaccacgc acgccctggt cggcggctgc gcgatgtacg gcgaggagac 40860
cgtcggctac ctctacgagg agggcatgac gctgtcgccc gacgggcact gcaagccctt 40920
cgcggcggac gcccgcggca tggtcggcgg cgagggagcc gtcgtcgtcc tcctgaagga 40980
cgcccgcgcg gcggtgcgcg acggcgacca catccacgcg ctcgtgcgcg gcgtcggcat 41040
gaacaacgac ggtgcccgca aggcgggtta ctacgcgccg agcctcaccg ggcagagcga 41100
actgatcgcc tccgtcctcg accgcgccgg ggtgcgcgcc gagtccgtcc gctacctgga 41160
ggcccacggc accggcaccg tcatcggcga ccccgtcgag gtgaacgccg tgtccgaggc 41220
gttccggcgc cacaccggcg ccaccggctt ctgcggcatc ggctcggtga aggcgaacct 41280
gggccacctc gacgcggcgg cgggcctcgc gggcctcgtg aagtccgccc tcgtcctgag 41340
ccaccgcacg gtgccgccga ccatcaacca cgaggcgccc aacccgcaga tcgacttcgc 41400
gaactccccg ttccacgtgg tggaccggct caccccgctg tcacccgcgg acggccagcc 41460
gctgcgcgcc gccgtcagct ccttcggcat cggcggcacg aacgtccacg ccgtcctcga 41520
agaggccccg ccgcgcgacg gcctcggcgc ggacctcccg gggccgcacc tcgtccccct 41580
gtcggcgcgg acgcccgacg ccctgcggcg gtacgcccgc gacctggccc ggcacctcac 41640
cgacgaggcg gccccggtgg cggatgtcgc cttcaccttc caggtgggcc gcaccgccct 41700
gccctgccgg gcggcgttca cggccgcgac cacggccgaa ctcgtcgccg cccttgagga 41760
cttcgccgag cgcgcgcagc cgggcgcaca gccgggcgcg cagccgaaca cgcaggcacc 41820
cgccgtcctc gacgtcctcg acgacgagga ccggcgcgcc ctgctcgacc agtggctcgc 41880
cgagcgcagg ctcgacaagg tggcccgcct gtgggaggcg ggcgagcccg tcgactggcg 41940
gcggctgtac gccgacgggc cgcgcccgca ccgcctgagc ctgcccgcgt accccttcga 42000
ggagcagcac ttctggctgc gcgccgagcc cccggcaccg gtcgaggacg cctccgtggc 42060
cccccgcctg ttcgcggagc actgggtggc gcgcgacgcc gcggcggtcg cggacaccgg 42120
cgcccggcgc gtggtcgtgg ccttcctgtc cgaccgcgcg gcccaggacg cctaccgggc 42180
cgcgacgctc cggcacgcgc ccggcacccg cctggtcttc gtcgccagga ccgacagcgg 42240
caccggcacc ggcaccccgg agcccgcgcc cggcgacgcc ggggccgcgc tgacggggta 42300
ccgcgtcgac cccgccgacg agcgcgccct cgcgcggacg ctcgtcgccg tcgccgaggc 42360
ccacggcccg ctcgacgccc tccactacct gtggcccacc gagcgcgcgg acggcaggcc 42420
gccgctgcgc gaactcgccg acgtcggcgt gctcgtacgg gccgtcgccg ccaccggcga 42480
caccgtccct gacgtcctcg tcgcgggcca ctacgacgac gccgtgggcc aggccgccct 42540
cgacgccctg atcggctacg agcgctccct gtccgggccg ctgcccggca ccgcgctgcg 42600
cgtcgtgctg cacgagggcg ccgtggccgc gggccgctgg gccgagctgc tcctgaccga 42660
gcagcaccag gagcagaagg ccgccgccct gtaccggggc gggcagcgcc acgtctgcga 42720
ggtgcggagc ctgcccgacg ccgccgcgca ccgcacgggt gccctgcgtg agggcggcac 42780
gtacctgatc accggcgcct tcggcggcct cggccgccgc gtcgccgggc acctggcccg 42840
cgcctaccgc gcgaacctcg tcctgctcgg ccgctcgccg ctgagccccg ccgacgagac 42900
ctgggccgcg gggctcggcg agcacggcgg cgccgtcgtc tgccgccgcg ccgacgtcac 42960
cgacgaggac gccctcgtcg aggcgctcag caccctgccg cccgcgctgc gggccatcga 43020
cggcgtcgtg cacgccgcgg gcaccgcgca gcggctcgcc gtgacggacg cgacccgcga 43080
cgccgcccgg cgcgtcctcg ccgccaaggt ggacgggacg ctcgccgtcg aacgggccct 43140
cgcccgcacg agcgccgggc gctccgcgga gttcatctgc ctcttctcgt ccagctccgc 43200
caccctcggc gacttcggca gctgcgacta cgcggtcgcc aaccgcttcc agtcggccta 43260
cgcgcgcgcc ctcgccgagc gcggcgagcg acggctgctc gccgtcggct ggccgctgtg 43320
ggaggacggc ggcatgggcg ccgccgccca gcgcgcggcc gaccacgacc acgtcaccgc 43380
gtacctggcc gccagcggcc agcggcccct cggcgccgac accgcgctcg ccgtcctcga 43440
acggctcctc gcggaacggt ccggcaccgc cgcgcccctg gtcctgcacg cgcccgccga 43500
gcgggccatc gccctggccg agcgggccgt cgcgcccgcg ccgcaccgcc cgcgaccggc 43560
ggcccccgcg gccgccggcc aggacccggc ccccgcgcgg gagccggccg cggtacacga 43620
ccggcgtcgc gccgccctgg ccgacgcggt gcgcgaggtc gtcgcgcacg tcctgaagtc 43680
ccccgcggac cagctggacg acgacagcgg cttccacgac ctgggcctgg actccatccg 43740
cctcacccag ctcgcccacc ggctcgccga acgcctcggc acgccgctcc agccgacggt 43800
cctgtacgac cacccgtcgg tacggcgcct gaccgaccac ctggccgacg aaccggacgt 43860
ccagctgccc gagtccgccg agcccgtcgt ggctccgacg gccccgcgcc ccgcccccga 43920
agccgccccc gccgaccccg gcaccgacag cgccgccgac gccgtcgccg tcatcggcat 43980
gagcggcatc ttccccggct gccgcgacgt ggacgccttc tggtccgcgc tcgccgacgg 44040
caaggacctc gtccgcgaac tgccgtccgc ccgcttcggc gcaccggcga ccggtgacgg 44100
gggcgcgccg cggccctacc ggtggatggg cagcatcgac tgggcggacg aattcgacgc 44160
cgccttcttc gagatcgccc ccaaggaggc gcgcacgctc gacccgcgcc agcgccacct 44220
cctccaggag tgctggaagg cgctggagga cgccgccctc ggcgcccagg agctggcggg 44280
ccgcaaggtc ggcgtgttcg tcggcgtgga acagggcgac taccagctcc tcgacggctc 44340
cggcggcaac ctcacctcga accacgacgg cgtcctcgcc gcgcgccttt cgtacttcct 44400
cgacctgaag ggccccgtcc tcgcggtcaa cacctcctgc tcctcgggcc tggtcgcgct 44460
gcaccaggcg cgcgcgagcc tgctccaggg ggagtgcgac atcgccgtcg tcgcggcggc 44520
gaacttcgtc ctgaccccgc aggcgctcgc cgccatggac gacgcgggca tgctgtcggc 44580
ctccggccgg tgcgccacgt tcgaccagga cgccgacggc atggtccccg gcgaggccgt 44640
cacggccctg gtccttcgcc cgctggcggc cgcggaggcc gcgggcgacc ccgtgcacag 44700
cgtgatcacg gccagcggcc tcaactacga cggccgcacc aacggcatca ccgcgccctc 44760
gggcgacgcc cagcgcgagc tcctggagtc cgtgtacgag cggggcggca tcgacccggc 44820
ggacatcggc tacgtcgtga cccacggcac cggcaccaag ctcggcgacc cggtcgaggt 44880
gggcgccctg cgcgcggcct tcgcccggca caccgacgag cgcgggttct gcgccctcac 44940
ctcgaccaag accaacgtcg gccacacctt cgccgcctcc ggcctggtcg gcctggtctg 45000
tctgaccgag gcgctgcgcc accgcgccat cccgcccagc ctgcactgcg agcgcgacaa 45060
cgagtacatc gactggagcg ccagcccctt ctacgtcaac aaggcgacga aggagtggcc 45120
cgccccgcgc cacggccacc gcaccggcgc ggtcagcgcg ttcgggatga gcggcaccaa 45180
cgcccacgtg gtcgtacggg agtacaccgg ccggccggtc acggcggctc cggcgcagcc 45240
cgcctacctc ctgccggtct ccgccaagac ggacacggcc ctggagggga tcgtcgacgc 45300
cctcctcgac cggatcgcga gcggcgccct gacggacgcc gacctgcccc ggctcagcgc 45360
caccctcggc accggccgcc accacttccg gcaccggtgc gccctggtcg tgagctccct 45420
cgacgaggcc gccgcgctct ggcgcggctg gcgccgcgcg cggacggccc cggccgacgc 45480
gtgcttcgag ggcgtcgtgc cccgcggctt caccgagcgg gcgcaggacg ccgaccggct 45540
ccgggccgcg gccgacagcg cccgggacac cgggctcgac ccggccgcgc gacgggcggc 45600
cctcgccgag gtcgcgcgcg gctacgtcgc gggccacacc gtcccgaccg ccgtaacccg 45660
gcccgactgc cgccccgtca cgcggctgcg gctgcccgcg tacccgttcg cgcggaaccg 45720
ctactgggtg cgcgccgagc agcagtcccc ggctccggcc acggctgcgg cgccggctcc 45780
ggtcagcctg accgcggcgg agccggtccc ggcgcccgcc gacccggccc ccgccccgga 45840
gccgcgcaag cccgtcgtcc tgcgggactt ggcggacata ccgcaccgaa tcgacaccac 45900
cgactcctca cccattgccg cgaagccgca ggtgtccctg gcgcccctga cggcgtccgc 45960
gcctgcccgt cccggcaccg cgcccgaggc cgcggaggca cggcccgtca cccgcgacca 46020
cgacgtactg gaagacctca aggcggcggc cgacctcgac ttcggcggga tggtcgccac 46080
cctgaaccgc accggcgtga tggtcgagcg gctgatcccg tactcccagg agttcgccgc 46140
gtacgcgggc gagagcggcg gcgaggccct ggacctgggc tgcgcgtacg gcgtggcgag 46200
catcgccgcg ctcgaacgcg gggcgcgggt ggtggcgctc gacatggagc agaagcacct 46260
ggacatcctc ggacagcgcg tcaacgacga ggcccgggag cggctttccc tgcgccaggg 46320
catgctgccc gacgtcgact tcgaggccgg gcgcttcacg gccgtgcacg ccagccgcgt 46380
gatgcacttc ctcgccccgg acgacttccg gctcacgctg cgcaagatgt acgagtggct 46440
ggcgcccggc ggcaaggtct tcctcagctc ggactcgccg tacttcggct actgggcgtc 46500
caaggccgcc gactacgagg cgcgcaagag cgcgggcgac ccgtggcccg gcttcatcga 46560
cgacgtcgcc gcgcacttcg aggcggccca cgtcgtcggc ggtccgccgc tgatcaacgc 46620
gatcgacccc gacgtgttcc gcagggagtg cgaggccgcc gggttcgtcg tggagcgggc 46680
cgggttcttc ggcgccgtgg gcgtggaccg ggagtcgtac ggcgcgcccg cccccgacat 46740
ggagcacgtg ggcgtcatcg cccgcaaacc ggacgaaaag gccacagtgt ccgatcccgc 46800
ggccacctcg gccgacggca cccgcatccg ctaccggacg cgcggcaacg gctccaccgc 46860
cctcgtcctc atccacggcc tcggctgcga cgcgtcgtac tgggaccggc agctggagca 46920
cttcgccgac cgctacaccg tggtcgcgcc cgacctcgcc gggcacggcg gatcgggcag 46980
ggcccggcgg cgctggaccg tggaggcgtt cgccgaggac gtcgtcgccg tcgtcgagca 47040
ggagggcctc gacgacgtgg tcctcgtcgg gcactccctc ggcgggcccg tgatgctggc 47100
cgccgagcgg ctcctgggcg gccgggtccg cggtctggtc ggcgtggaca cgctgcacaa 47160
cttcgagccc aaggcgctct ccgccgagca gctcgaccgg ttcgtgcgga cgttcagcga 47220
gcagccggtg gaagcgcggg agctgttcct cgacggcgcg cgcgacgacc tcgtcgccct 47280
ggtcgcgcgc acccgcgagg agaccggggc ggacgtggtg tccgccgcgt tccgcgagat 47340
gctcacctac ctccaggacg tgcccaagca cttcgacgtg ccgctcgtac tgatcaactc 47400
gacgtcctgg atgccgacga acctgaccgc ggcgcgccgc tacggcgtcg aggtggaact 47460
ggtcgacggc gtcgggcact tcgtgatgct cgaggcgccc ctcaccttca acgcgaccct 47520
gcgccgccgt ctggagcagc tcgttcctga cgtcgccgca ggtcaggacg gcagcgggcg 47580
cggagcccgg acggaagggg ccgattcctg atggccgcgc cacgtattaa gatccacgcg 47640
aaaagcgacc tgcatcggta cctgcgcgac acgctggccg tcgtccttgg aaccgaagtg 47700
gctccgagcc gtgacgacgt gtccctcgtg gagctgggtc tcgattcgtt cggctgcgcc 47760
cagtggctgc acgaggtcaa ccgaaccctc gggctttccc tcacagtggc ccaggtctgc 47820
ggtcacccca cgttccgtac gttgtccgcc ctgatcgagg gcgccatggg agaacagatg 47880
agtgccacac ccgctgggtc ctctgccgcc cgcggcacgt ccgcgcccgg gcgccaggcc 47940
atcgccgcgc acctgcgtga gagcctcgcg gcggagctgg agctcgtcgc ggcggacatc 48000
gacgacgagg cgcccttcgt ggagctgggc ctcgactcga tcaccggtgt cacctggacc 48060
cggaagctga acacgcactt ccagctgtcg ctctccgcga cccaggtcta cagccacccc 48120
acggtcgacg agctcgcggg gcacttggcc gagctgctcg gcggcggcgc cgacgacgaa 48180
ccggtgcagg ctcccggcga tgctgagccc gagcccgttg aggcgacccc cgtgggcccg 48240
gacgcaccgg catccgcgca cgccgcggag tccgcgctcg ccgcgtggct gcgggccagc 48300
ctcgccaagg agctggagct cgccgcggcc gaactggacg acgaggcgcc cttcgtggag 48360
ctggggctcg actcgatctc cggcgtcacc tggacccggt ccctcaacac gcgcctgcgg 48420
ctctcgctgt ccgcgaccac ggtctacggg cacccgacga tcagcgacct ggcgcggtac 48480
ctgacgcggg agcacggcgc ggtggccccc gacgcggggg agggcacacg gcccgaggcc 48540
gcctcggcag cggagcccga gccgcagccc gccgtcgtcg agcccgagcc cgtcgtagag 48600
cccgagcctg ccctggaagc cgcgcccgcc gctgcgcccg agcccgccgc ggcagcggag 48660
cccgagcccg cgccgcagcc cgctgcccag gcgtccccgg cacccgcccc cggggccggc 48720
ctcgtggaca tcgccgtcat cggcatctcc ggcgcgttcc cccaggcgga gaacgtcgac 48780
gcgttctggc ggaacatcct ggacggccgc gactgcatat ccgaggtgcc gtcctcgcgc 48840
tggcccgtgg agaagttcta cgacgaacgg cccggcgtgc cggggaagtc ctccagcaag 48900
tggatgggcg tcctggagaa cgcggaccgc ttcgacccgc tcttcttctc catctcgccc 48960
ggcgaggccg aggccatgga cccgcagcag cgcgtcctgc tccaggagac ctggcgctgc 49020
gtcgaggagg cgggctacag ccccgacgac ctctccggca cccagtgcgg cgtcttcgtc 49080
ggctgctccg tgaacggcta cggcgccacg gccgacgcgg ccgggctcag cgcgcaccag 49140
aacctcggca ccaacagcgc catcctcgcc agccgcgtct cctacaccct gaacctcaag 49200
ggcccctgcc tctccatcga cacctcgtgc tcgtcgtcgc tcgtggccat cgcccaggcc 49260
tgcgacagcc tctgcctcgg tgacagcgac accgcgctcg cggccggcgt ctgggtcatc 49320
ccgggccccg gcgtgcacgt ggccatgagc cagctgcggg ccctgtcgcc cgacggccgc 49380
tgctacgcct tcgacgagcg cgccaacggc ttcgtaccgg ccgagggcgt gggcgtcctg 49440
ctcctgaagc ggctcgcgga cgcccaggcc gacggcgacc ggatccacgc cgtcatcaag 49500
ggctggggcg tgaaccagga cggcaggtcc aacggcatca ccgcgcccag cgccgaggcg 49560
caggcccggc tccagaagca cgtgtacgac aagttcggca tcgaccccgg tgacatcgag 49620
ctcgtcgagg cgcacggcac cggcaccgcc ctgggcgacc ccgtcgagat cgacggcctc 49680
gtcgacagct tcaccgcgcg caccgaccgc cgcggccact gcgccgtcgg ctcggtgaag 49740
agcaacatcg gccacaccgc gtgcgccgcc ggagtggccg gcgtcctcaa ggccaccctc 49800
gccctggagc acgcgacgct gccgccgacc gcccagtacg agcgcctcaa cgagcacatc 49860
gacctggacg gcacgccctt ctacgtcaac acccgggcgc gcgagtggcg gcgcgcggac 49920
cggccgcgcc tggccgccgt cagctccttc ggctacagcg gcacgaacgc ccacgtcgtc 49980
ctggccgagg cccccgacgc cgcggcccct gcgtccgaac gccccggcgg ctcccgtctg 50040
atcgccctgt ccgcccgcac ggccggacag ctccaggacc aggcgcggca gctcgccggg 50100
cacctcgaag cgcaccccgg cctgagcctg cgcgacgtca gccacaccct ggggcggggc 50160
cgcaagcact tccgccaccg cctcgccttc gtcgtcgaca gcacggcagg ggccgccgcg 50220
ctgctgcgca cctggctgga gaccggcagc gcgccgtccg cgtacgccgg tgaccacaag 50280
ccccggcgcc cggcgcggcc cgacgtgcgg gaggccaggg aactgacgga cccggaccgg 50340
ctgcggacgc tcgccgacga gtacgcccgg ggcgcggccg tcgcgttcga gctgctcttc 50400
gcagccgacc ggcgcccggc ccggatctcg ctgcccacgt acccgttcgc ccaggactcc 50460
tactggctgt ccggcgaagc cccttcgtcc gacgagcctg ccacggagga cgacgctgag 50520
gacagggctg agggcgccgc cgagaagccg gaaggcccgg tcgacctgct ggccctggag 50580
ccgtgctgga caccgctgcc cacgccgccc gccgcccccg acgccgaacc ggacgactgg 50640
gccgtgtggc tcgtcggccc cggcgccgac gcggcggggc gcgcgctgcg cacccggctg 50700
ccccgcaccg tggtgctgca cacgtccgag gtggccgcgg accgtccgct ggacgccgcg 50760
tacgcccgtc tgatccggga cgtcctgggc gagctgcgca cccggatcgc cgccggtgac 50820
ctgccggacg gcggcctcgc gcagatcgtc gtcctggggc acggcgcccc ggccgcgcgg 50880
gtgctgaccg gagtgaccgg gctgctgcgc acggccgccc tcgaacaccc gtggctgcgg 50940
gcccagctcc tggagcacct cgaccccttc gacgccgccg acgaccggtc cgtggccgcg 51000
ctcgccgaag ccgtcgaggc gggcgcccgc gcccacaccg agcagcacgt ccgccagcag 51060
ggcggcctgc ggtacgccct gcggctcacc gaggtcgagg cgcggcccgc gcacggggcc 51120
gccgcgtcgc cgtggcgcga cggcggcgtg cacctgatca ccggcggcac cggcggcctc 51180
ggcctgcacg tcgccgggga gctgtcccgc accctgcgca ccggcacggt cgtcctcgtc 51240
ggacgctccg cccccgaggc cgcacggccg cgcctcgccg ccctcgccac gccgggcgtc 51300
accgtcgagt accggcaggc ggacgtcacc gaccggcggg ccgtcgacgc gctcgtcgcg 51360
gacgtcgtct cccgccacgg cgcgctgcac ggcgtcgtgc actgcgccgg agtgctccgc 51420
gacggctacc tcgccaccaa gaaggacggg gacctggccg ccgtcctcgc ccccaagacc 51480
accggcctgg tcaacctcga cgaggccacc gccgaccagc cgctcgacca cctggtcgtc 51540
ttctcctcca cggcggccgc gctcggcagc gcgggccagg gcgactacgc cgcggccaac 51600
gcgttcctcg acgcctacat ggagtaccgc gccgacctcg ccgcgcgcgg cctcaggtcc 51660
ggccgcgccg tgtccgtcgg ctggcccctg tgggccgacg gcggcatgcg gctcgacggc 51720
gcgtccctgg agcggctgcg cgggatcggc gtgacgcccc tgcccaccgg cgaaggactg 51780
cgggccctga ccgcagccgt cgcgggcggc gcccggcaca ccctcctgct ctgcggcgac 51840
cgcgagcggc tgctcgaccg cctggccgcg cacatcacca cggagcggca gccgctgccg 51900
acgcccgccc cggccccggt cacggacgcg cgccccggcc gccaggagtg ggagcgcacg 51960
ctggccgccg ccgtctccga gcagctcaag gtccccgccg aagagatcga cggggacggg 52020
gagttcggcg agtacggctt cgactccatc agcctgaccg agctcgtgca gcgcctgaac 52080
gacgcccacg ggctgagcct ggcgcccacc gtgttcttcg agcacaccac cgtgggcgcg 52140
ctcgcggccc acatcgccga gcacgcaccc gcggcccaca tcgccgagca cgcgccgacg 52200
cccgccgagc ccctgcccgc cacggagccg acgcggcccg ccccggtcgc cgcggtcgtc 52260
gcgcccgatc tggacgcgat ccggcaggcc gtcatcgccg aggtgtccgg gcagctgaag 52320
gtccccgccg atgagatcga gggcgacggg gagttcggcg agtacggctt cgactccatc 52380
agcctgaccg agctcgccgg ccgtctcggc gaccggttcg gcgtgcggct ggcgcccacg 52440
gtgttcttcg agcaccggac cgtggacagc gtggcggcac acctggcgga gacggccccc 52500
gcgccgacgg tcccggccgc cgaagtcccg taccaggaag agccgttgga gcacgccccg 52560
gccgaggcgg gcctctccgc cgagcccatc gccgtcatcg gcatgagcgg cagcttcccg 52620
caggcacccg acctgtcggc cttctgggac aacctgtacg cgggcaagga ctgcatcacg 52680
gagatccccg gggaccgctg ggactggcgc gccctggctg aggacccgga cgtcccgcgc 52740
ggcaagaagc ccgtgcgctg gggcgggttc ctcgacggcg tcgacacgtt cgacccgctg 52800
ttcttcggca tctcgccccg cgaggcccgc accatggacc cgcagcagcg gctgctgctc 52860
acccatgcct ggcaggccct cgaagacgcc ggttacgcgc cttccggtct ggcgggaagc 52920
gacaccgccg tcctgatcgg caccgcgccg agcggctacg gcagcctcgt catgggggag 52980
cgggccgggg aggacgggta cgccgcgacc ggcgtctccg gctccgtggg ccccaaccgc 53040
gtcagctacc tgctcgacct gcacggcccc agcgagcccg tggagacggc ctgttcgagc 53100
tcgctcgtcg ccctgcaccg cggtgtcgag ctgctccgct ccggccgcag cggcctcgcg 53160
ctcgtcggcg gcgtcaacac catcgtcagc cccgacctgc acatcggcta cagccgcgcg 53220
ggcatgctgt gcgaggacgg ccgctgcaag acgttctccg cacgggccaa cgggtacgtg 53280
cgcggcgagg gcgtcggcgt cctgctcctc aagccgctgc gccacgcccg gcgcgacggc 53340
gaccggatcc tcggcgtcat ccgcggcagc gccgtcaacc acggaggccg cgcccactcg 53400
ctcaccgcgc ccaacccgcg cgcccaggcc gacctcctca agagcgccta ccgcgacgcg 53460
ggcgtcgacc cgcgcaccgt cacctacgtc gaggcgcacg gcaccggcac cgaactcggc 53520
gaccccgtcg agctgaacgg cctcaagagc gccttcggcg agctgtacgc ggagacggcc 53580
gaggcgcccg gccgtctcga cgcaccggcc cgctgcggcc tcggctcggt caagagcaac 53640
atcggccacc tggaactggc agcgggcgtg gccggagtca tcaaggtgct gctccagatg 53700
cgccacgcca ccctggtcga gagcctgcac tgcgcggacc tcaacccgta tctggacttc 53760
acggacagcc cgttcgaggt cgtccgcgag cggcagccgt ggcagcggcc gcgcgacgcc 53820
gacggccggg cgctcccgcg ccgggcgggc gtcagctcct tcggcttcgg cggcgtcaac 53880
gcgcacgtcg tcatcgagga atacgtcgac gagcacgatg agcacgacga ggaccacggg 53940
ggacacgcgg ccatggaaac gcacgccgac gcgcacacgg gcaccgcgcc ccgggccggg 54000
gcacccgcac cggccgcggc gctgatcccc ctgtccgcgc gcaccgagga gcagctcgtc 54060
gcgcgggccc gggcgctgcg cgaccacctc agggccgggc acgaggcacg cctcgccgac 54120
ctcgcgttca cgctccaggt gggccgtgac gcgatggagg agcggctcgc gacccgggtc 54180
acctcgctcg ccgacctgga gcgcaggctg acgtcgttcg tggccgaccc cggcgcccac 54240
gacggctggc accgcggcac ggtgtcccgc aggaccggcg ccgcgcagga caccgggcac 54300
cccctcgtgg cgggggagca cgacgaagcc ctcgcccggt gggtgaccgg tcacccactg 54360
gactggcgga gcctgtacgc gccgggggcc cggcccgtgc gggtcggcct gccgacgtac 54420
ccgttcgccg aggagcgcta ctgggcgggg cgcgccaccg cgcccgccgc cgggcccgcg 54480
gccgcgcggc cggacaccgc gcccgacgcg cacccgatgc tgcaccagcc ggtgggcggc 54540
accctgtcgg cgtaccgcac cgtcttcgac ggcgccgaac ccttcctgaa ggaccatcag 54600
gtacgcggcc tgcgcgtcct gcccggcgcc gcgcacctgg agatggcccg cgccgccgtc 54660
gcccgcaccg cgggaacggc gggccgcgtc cggctgagcg acgtggtgtg gctgcggccc 54720
gccgcctgcg ccacggacga cggcctcgac gtgcgcctcg acctgaagcc gacgggcacg 54780
gacgcctacg cgtacacgct ccacaccgtc ggcgccgacg gcgagcggac gctgtcgagc 54840
cagggccgcg cccgcctggc ggacgcgccc gccgagcgcc cggcgctccc gctcgcggac 54900
ctgcgcgccg cctgcgccga cgccgccttc accgccgccg acgtctacgg cctgtacgac 54960
cgcgtgggca tggagtacgg cccggcgcag cgctcgctca ccgccctcgc cgtcggcacc 55020
gacaccgcgg ggcgccccca ggcgctcgcc gaactgcgcc tgccccgggc ggcggaggcc 55080
accgacgcct acggactgca cccgagcatc ctcgacggcg ccctccaggc caccatcggc 55140
ctcggactcg gcggcggcga cggcgcggcc cccgcacggc ccgcgctgcc cttcgccctc 55200
caggaagcgg acgtcctggc cgccaccccg gcgacggcgt acgcctggat ccggtaccag 55260
gacggcagcc gccccggcga cacgtccgcg aagctggaca tcaccctcct cgacgccgag 55320
ggacgggtgt gcgcggagct gacagggctg ctcgcacggg tgctgcccgc cgatgcggcc 55380
ccgaaggccg ccgagccgac cgcgcgcccc gccgcaccgg ccgtcggcac cccgctcgcc 55440
cctctcgccg agcgcgcgct gccgtacctg cgcgaccagc tcgccaccgc gctcgaagtc 55500
gccgccgaac gcctcgacgt ggacacgccg ttggagttct acggcatgga ctccatgatg 55560
gcgatggagc tcacgcacca cctggagggc accttcgggg agctgtcgaa gacgctgttc 55620
ttcgaggtcc gcaccatccg ggcgctgagc gagcacttcg cagaggcgta cccgcagcgg 55680
ctgcgcgccg ccctcggcgg ccaggccccg gaggctcagg aggccgacac gcaggccccg 55740
gcccaggctc cggcggggac cgccctcgcg cggccggaca cgggccacgt caccgacatc 55800
gcgatcgtcg gcgtgagcgg ccgctacccg ctggcggaga acctcgacga gttctggcgg 55860
aacctgcgtt ccggccgcga ctgcgtcacc gaggtcccgg cggaccgctg ggacccccgc 55920
gaccacgagg gcacgtcccg gtggggcggg ttcctcgacg gcgtcgaccg cttcgacccg 55980
ctgttcttcc gcatctcgcc gcgcgaggcg gagttcctcg acccccagga gcggctgttc 56040
ctggagtgcg tccaccacac cctggaggac gccgggtaca ccggcgagac cctgtcccgg 56100
cagtccgccg gacgggacgg cgccgacgcg ggcctcgtcg ccaccggcaa ggtcggcgtg 56160
ttcgtcggcg tgatgtacga ggagtaccag ctccacggcg cccaggcgca ggcgcgtggc 56220
caccgcgtgg cgctctccgg cagcccgtcg tccatcgcca accggatctc gtacttctac 56280
gacttccacg gcccgagcat ggccgtggac accatgtgct cctcctcgct gaccgcgatc 56340
cacctcgcct gcgaggcgat caggagcggt cagtgcgagg cggccgtcgc gggcggcgtc 56400
aacgtcagcg tccacccgaa caagtacgtg atgctgagcc agggcaagtt cacctcaagc 56460
gacggccgct gccgcagctt cggcgagggc ggcgacggct acgtgcccgg cgagggcgtc 56520
ggcgccctcc tgctcaagcc cctggaccgg gccgtcgccg acggcgacca gatccacgcg 56580
gtcatcaagg gcaccgccct caaccacggc ggcaggaccc acggcttctc ggtgcccaac 56640
ccggcggccc agggtgacgt catcacccgc gcgctcgccc gtgccggggt cgcgccgcac 56700
gagatgagct acctggaggc gcacggcacc ggcacctccc tcggcgaccc catcgaactg 56760
accggcctgg tcaaggcgtt cgggcggacg accggggcga ccgcgccgac ctgcgcgatc 56820
ggctcggtca agtccaacat cggccactgc gagagcgccg cgggcatcgc gggcgtcacc 56880
aaggtgctgc tccagatgcg ccacggcgag ctggtaccca gcctgcacgc gagcaccctc 56940
aacccccatc tggacttcga cgggacgccg ttcaccgtgc agcgcgacct cgcgccgtgg 57000
cacgggccgc gcgtcgcggg cgtctccagc ttcggcgcgg gcggcgccaa cgcgcacgtg 57060
gtcctggccg cgtacgagcc cgatgacgcc cccgccaccc cccggacgcg ccccgtcgcc 57120
gtacccctgt cggccgcgac cgaggaccaa ctgcttgaag ccgcacggcg gttgcgggcc 57180
cgcgcggacg gcctcaccga ggacgacctc gccgcgctcg gctggacgct ccagaccggc 57240
cgcaccgccc ttgaggagcg cctcgccttc accgcggact ccctggagtc cctccggcgc 57300
accctcgacg cgttcctggc cgaccccgcc gccccgggcg actgggtacg cgaccgggtc 57360
agggccgacc gggccccggc cgcggcggac ggcgaagcca ccggacccca ggagtgcgcg 57420
gcccgctggg cgcgcggcga agccgtcgac tgggacctgc tgtacgcggc ggacggcacg 57480
gcacgcccgc gccggctgag cctgcccggc taccccttcg cccgcgagcg ccactggctc 57540
gacctggaga cggtgacggg ccgtgagccc gccacgccgg accacgtcct cctgacgcac 57600
cccgtgtggg aggccgagga gcccgcagac gcgacggcca cgcccgcgcc cgagcggcac 57660
gtcatcctcg tcggccggtt cgcgccgggc gaggagcccg cgctgaccac ggccctgacg 57720
gcggtgctgc cgggcgcggt gcaccacgag accgtggccc tggccgccga cgcccccctg 57780
gacaccgcgt acctgacggc ggcacggcac gtgttcgccc gggcgcgcgc cctcctgacg 57840
gatggcgtgc gcggcggcgc gctgctccag gtcgtgctcg tcggcgaccg cggccaggag 57900
gcggcgggtc ggaccgtgtt cggcggtctg agcggtctgc tgcggaccgt ggccctggag 57960
aacccgaggc tgcgcaccca gctcgtggac tgcctcgacg gcgccgcgcc cgccctcgtc 58020
gccgagcggc tgcgcgcgga gacggccccc gagacggcgc ccgaagtccg ctaccgcgcg 58080
ggccgccgcg aggtcaggcg gctcacggag ctggctcctg cgccggacgc gggcgccgcc 58140
ccgtggcgcg cgggcggcgt gtacctcatc acgggcggca ccggggccct cggcctcgtc 58200
acggcccggg acatcgcgtc ggccgccgcg ggcgccaccg tcgtactgac cgggcgctcg 58260
gcgctcgacg acgcgcagcg ggaggcgctc gacggcctgc gggccgcggg cctgaccgtg 58320
gaccaccagc gcaccgacgt caccgaccgc gccgacgtgg aacgcctggt ggcgcacatc 58380
gcgcggacgc acgggccgct gaccggcgtc gtgcacgccg cgggcgtgct gcgcgacaac 58440
ttcgtcgtga acaaggcgcc cgaggaattc gcgcgcgtcc tcgcgccgaa ggtcgcgggt 58500
ctcgtccacc tggacgagct gacccgggac cagccgcttg agctgttcct gtgctactcg 58560
tcgacgaccg gtgccctggg caacgcgggc caggccgact acgcggcggg caacgccttc 58620
atggacgcct acgccgccca ccggggccgc ctcgcggccg ccggagcgcg ccacggcctg 58680
accctgtccc tgaactggcc cctgtgggcc gagggcggca tgggcgggga cgcagccgtc 58740
gcggaccggc tgcggcggat ggacctcgtc ccgctggaca ccgagagcgg tctgcgcgcc 58800
ctgcgcaccg gcgtcgccgc acgccgcacc ggcctcgcgg acggtcagct cctggtcgtc 58860
gccgggcggc gcgacgcggt cctgccgcgg ctgaccgcgc gacccgggcg ggcaccggcg 58920
gccgagccgc gcgccggtgc cgaggagcgg gccgccgcgc cgacgcctcc cgccaccgcg 58980
ccgacgtccc ccgccggggc ggcgggcggc gaccgggccc tgctcgaccg cacccgccgc 59040
cacctgcgcg cgcacctggc ggcgggcctc aagctcggcg ccgaccggct cgacgcggag 59100
gtgcccctcg agcgctacgg catggactcc gtcgtggcga tgaacctgat cgcccagctg 59160
gagacggact tcggctccct gcccaagacc ctgttcttcg aggtgcagac ggtccgcgag 59220
ctcgcggagt acttcgtcgc cgagcacggt gacgcgctgc gcgcgctgtt cggcgagacg 59280
gtcgccgcgg tgcccgcacc ggagcccgca ccggccccgc tcgccgccga gcccgcgaag 59340
gcccagcgcg aggaggcgca gcccgcccca gtaccgtccg ccccggtacc gtccgccccg 59400
gtaccgtccg ccccggtacc gtccgccccg gtaccgtccg ccccggtacc gtccgcttcg 59460
atcccgcccg tcgcgatccc gcccgtcgcg atcccgtccg tcgcggtccc gaccgtttcg 59520
gtcccgtccg cacgggaccc gcgcgacgag ggcgtcgccg tcatcggcct cgccgggcgc 59580
tacccgggcg ccgccgaccc cgacgccctg tggggcctgc tgcgctccgg cgccgactgc 59640
gtcaccgagg tccccgccga ccgctgggac cacgacgcgg tgttcgaccc cgaccgcgag 59700
gcggtcggca agagctacgg caagtggggc ggcttcctcg acggcgtcga ccagttcgac 59760
ccgctgcact tcggcatctc gccgcgcgag gccgagacca tggacccgca gcagcggctg 59820
ttcctggaga cggtgtggca gctcctggag cagagcggcg tcacccagga ggccgtcgag 59880
cgcacgtacg gccgccgggt cggcgtgtac gtcggcgcga tgtaccagat gtaccgggcc 59940
gacaccgccg acgtggtgcg ctccgccctg acgtcggcgg cgtcgtacaa cctcatcgcc 60000
aaccgcgtct cgcactactt cggcctggag ggcccgagcc tcgccgtgga cggcatgtgc 60060
gcgtcctcgg cggcggccat tcacctggcc tgcgccgatc tgctgagcgg cgacagcgag 60120
ctggccatcg cgggcggggt gaacctgacc gtccacccgg acaagtaccg ggcgctgtcc 60180
cgggcgggcc tgctcggcag ccaccccggc agccgcagct tccgcgacgg cgacggctat 60240
ctgcccgccg aggcggtggg cgccgtcctg ctcaagccgc tggccgccgc ccgcagggac 60300
ggcgacaccg tcctcgccgt catcaagggc agcgcctcgc tgcacggcgg ccgcgcgggc 60360
cagttcatgg ccccgagccg caggacgcag gtgaacgtgg cccgcagggc cctggagaag 60420
gcgggctgcg agcccgcgtc gatcggctac gtggaggccg cggccaacgg gtccgcgctc 60480
ggcgacgccg tcgaggcggg cgcgctccgc gaggtcttcg gcgacgtcac cgagccgatc 60540
gcgctcggct cggtgaagtc caacctgggc caccccgagg ccgcgtccgg catcgcccag 60600
ctcaccaagg tcatcctcca gctccgccac cgggagctgg cgccccgcac cgcggtcggc 60660
acgcccaacc ccgaactccg cctggacgag ggtccgttgc ggctgtgcga gacgctgacg 60720
ccctgggagc cgcgccccgg cacgccccgg cgcgcgctgc tcaactccgt cggagcgggc 60780
ggcagccacg tcagcctcgt cgtggaggag gcgccggagc ccgagcgccc ggaggccaac 60840
cggccgcagc cgacgcggcc tgagctgatc ctgctgtccg ccggtgaccc cgagcggctg 60900
cgcaccgcgg cccgcctcct gcacgacttc gtcgagcgga gcgacgcacc gggcgcggac 60960
gccgccgcct ggctcgccga cgtcgcccac acgctgcgcg tgggcaggga agcacaggcc 61020
gagcgcctgg cgttcgtcac ggactcccgc gcgggcctgc tgcgcacgct cgccgatttc 61080
ctggcggacc ggcccccgta cggcccgctg taccggggcg acgcggaggc ggggggcgcc 61140
accctgggcg acctgctcgc gggcggccac ggcgaggcgt tcgtccgcgc gctcgtgacc 61200
gacggcgaac tcgaccggct cgccgagctg tgggtgcgcg gcggccggat cccctggcgc 61260
gcactgcaca ccgggcaggg gcgccgactc gtaccgctgc cgacgacggc gttccggcgc 61320
aagcggtact gggtggggca cacgggtacg ccgacggcgg ccacagacac ccccgcggcg 61380
gccacagaca tctccacggc ggccacgggc acgctcgcgg cggctcccgc acccgacgcg 61440
gccaccccgc acaccgacca gcaccccgac cccgtcgccg aacccgacgg cgccgggcgc 61500
ggcgacgaca tcctgcgcta cctcgcggac tacttcagcg acgccctcgg cttcggcccc 61560
ggcgaactcc cgctggacaa ggacctgcac agcctgggcg ccgactccgt cctgtgggtg 61620
cgcctgcggc gcgcggtgga gaccgacctc ggtctcaccc tcaccacccg ggagatcgtc 61680
gaactcacca ccctggagcg catcgcggac cggctcgccg cgaagcgcgg aaccccgcag 61740
ccacccgaag caccggacgt acgcgaagca cgggccaagg ccctggagca gttccgccag 61800
ggccacgtcg gactcgaaga actcaagtca ctcatgaagg aagcaccggg cgcgtgaacg 61860
aggatcagat tctggcgggc ttcaaggcgg gcctctacac cgctgaggac gtgctcgcgt 61920
tctacgaacg actccaggac tccgcgcagg cgggcgtcac ggaccggcgt gccctctccg 61980
agggccagaa ggggctgtgg ctgctccaca agctgcggcc cgcgtcggac gtgtacaacg 62040
tccccgtctg cttccgcacg tcggcgccgt tcgacgtcgc ggtcttcgag gaggccttcc 62100
ggcaggtgac gtcccggcac gcgctgctgc acagcgtggt cgtcgaggac gagggcaccc 62160
cgtacctggt gcggcgcccc gacggcggcg acgcgccctt ccggcaccag accgtgccgc 62220
aggggctgcc cgacgacgtc ctgctcgccc tggcgcgcga gcaggccaag gcgcccttcg 62280
acctgcacga ggagggaccg gcccgggccg tcgtgtacac ggcgggcacg gccgaggcgc 62340
cgcagaccct cgtgctgctc gtcctgcacc acctggtgtt cgacggcgcc tcgacccccg 62400
tcctgctgcg cgacctgctc cgcacgtacg acaccctgct ccagggcggc acgcccgagc 62460
ccgcggccgc gcggcacgac gcctacgacg cgttcgtgcg ctgggaggcg gacttcctcg 62520
cgggccccga aggcgcccgc caccgcgcct tctggcagga caccctggcg ggcgacctgc 62580
cggtcctccg cctcggcatc gagcgcgccc ccgcgcccgg cgccgccgtg gtgggcgaga 62640
ccgtcgccct gccgctgccc ccggccctcg ccgcccgcgt gcgcgacctg tgcgcggccc 62700
gcggcgccaa gcccgcggtg ctcttcctcg ccgtgtacga actgctcctg caccgctaca 62760
gcggcgagcg cgacctcatt gtcggcgtgc cctccctggg ccggccggac gcgacctacg 62820
acgacgcggt cggctacttc gtgaacatgc tgcccgtgcg ccacggcgtg cgcggcgacg 62880
tgccgttcac ggacttcgtg cgcgacctga cgctcgtcat ggccgacggc ctcgaccacg 62940
ccgcgtaccc gttcccgcgc atggtgcagg acctgaacct gcgcacggac cccgacacct 63000
ccccggtctt ccaggtgtcg tacgtcttcc agaaccagcg catgatgcac gtcacggacg 63060
gcgacgtgct cggcctcgac ctggcccgct cgctgcggtt cgtggaggag atatcccagg 63120
agggggagtt caagctccac ctggaggtcg tcgagcacgc cgccgacgcc tacacgctgc 63180
acctcaagta cgacgccgcg cgcttcgacg cggcggacgt cgagcgcttc ctcggccact 63240
acgagaccct cctgagcgcc ctcgtcgacg ccccggagca gctgctttcc gaggcctcgc 63300
acctgtcgga cgacgagctg cgccgcttcg acgcgtggaa cgacaccacc cggcccttct 63360
ccgccgagcg cagcctgccc gacctgctcg ccgacgccgt cgcccgccac ggcgaccgca 63420
ccgccctcgt gtacggcgag cgctccctga cgtacgccga actcgccgag cgcaccgacg 63480
ccctggccgc cgagctgcgc cgccgcggcg tcaccgcgga caccgtcgtc ggcatctcca 63540
tggaacgctc catggagatg gtgatcgccc tgtgggcggt catgaaggcg ggcggcgcct 63600
acctcccgct cgagccggac tacccggccg aacgcatcca gtacatgatc gaggactcgg 63660
gcgccgccct cgtcctcgcc cagtccgcct ccgacgtctc cgccctggcc ggggcgcgca 63720
cggtgctccg cctggacacc gaaggacggc cggtccccga cggcgccccg cgcgcccagg 63780
acccggcagc ccccgcccgg atcgcccccg gcgacctcgc gtacgtcatc tacacctcag 63840
gctccaccgg ccgccccaag ggcgtcatgg tcgagcaccg cgctgccgtc aaccgcgtcg 63900
agtggatgca gaacgagtac gcgctgaccc ccgacgacgt cgtgctccag aagacgccgt 63960
tcagcttcga cgtctccgtg tgggagttcg tctggccgct gatcacgggc gcgcgcctgg 64020
tcgtcgccgc gccgggcggc cacaaggacc ccgcgtacct ggtgtcgctc atccgcgccg 64080
ccgaggtcac caccgcgcac ttcgtgccgc ccatgctgcg cctcatgctc gaccacgagg 64140
gctgggcgcg ctgcacctcg ctgcgccagg tcttctgcag cggcgaggcc ctgccgccgg 64200
agctgcccgc gcggcactac gcccagcacc gcgcccgtct gcacaacctg tacggcccca 64260
ccgaggccgc catcgacgtc acccactggg cctgcccgcc cgacaccacg gcgcgcgcgg 64320
tgccgatcgg ccgcccgatc cagaacatcc agctgcacgt cctggacgac ctgggccggc 64380
tgcaggccgt gggctgcgcg ggcgagctgc acatcgcagg cgtcggcctg gcccgcggct 64440
acctcaacaa ccccgctctg acgcgcgagc gcttcgtccc gaacccgttc gccgcggacc 64500
cggacgcccg catgtaccgc acgggcgacc tcgtccgccg gctgcccgac ggcaccctgg 64560
agtacctcgg ccgcatcgac aaccaggtca agctgcgcgg cttccgcatc gagctcgacg 64620
agatcgagga ccgcctcgcc cgccaccccg ccgtgcgggc ctgcgccgtc ctcgcccgcg 64680
aggacagccc cggcagcccg cggctcgtcg gctacgtcgt cctcgacgag gcgcacacgg 64740
gggagttcca cgacaccctg gtgcgccacc tcgggcagtc gctgcccgag tacatggtcc 64800
cgggcgccct ggtccgcctc gacgccctgc cgctgaccgc caacggcaag ctcgaccgga 64860
aggcgctccc ggcccccgac gccgacgcgt acgccgtggc cggtgaccgc gtcgccccgc 64920
gcacgcccac cgagcggacc ctgctcgcgg tctgcgcggg cctgctcggc ttcgacgagg 64980
agcgcatcgg cgtccacgac aacttcttcg ccctcggcgg gcactcgctg ctcatcccga 65040
agctgaccgc gcgcctgcac gacgcggggc tcgactgcga gctgcacagc gtgttcgccg 65100
ccgccacgct cgccgacctg gccgccgcga tcgacgcggc gcacgccaag gcggaccccg 65160
gcgcgcggga cgcggcggac gccgccccgg cgcggacggc gttcaccgta ccgccgaacg 65220
gcatccccga ggactgcgac cggctcaccc cggacatgct gcccctggtc tccctgaccg 65280
aggacgagct ggcggcggtc gtcgccgccg tgcccggcgg cgcgcccaac gtccaggacg 65340
tgtacccgct ggcggccctc caggaaggca tgctcttcca ccacctcaag gagagcggcc 65400
gcgacccgta cgtgctctcc ggcgtgttct ccttcgagag caggtcccac ctggacggct 65460
tcgtgcgcgc cctgcgcgcg gccgtcgccc ggcacgacgc gctgcgcacg gcgatcctca 65520
cccagggcct gtcccggccc gtccaggtcg tggtgcgccg cgcggagctc gacctggagg 65580
agttcgaggt gcccgcgggc cgcgacgccg agggcgagat ccgcgaactc ctggcccggc 65640
cgcaggcgat gcgccttgac cgcgccccgc tgatccggct gcgcgccacc cggcagccct 65700
ccaccgccac ctggtacgcc gcgctcaacc tgcaccacgt catcgacgac gcgacctcgc 65760
tgggcctgct gttccgcgag gtcgtcgccc atatgacggg ccgcgcgggg gagctggccc 65820
cgcccgctcc gtaccgcgac ttcatcgccc acgtgcagca ccgcgcgcgc gagctcgacc 65880
cggcggacta cttccgggac cggctcggcg acgtcaccga gcccaccgtg atgttcgggc 65940
tccaggacgt ccacggcgac ggccgcagcg tcctggacct gcgccgcccg ctggccgccc 66000
gcctcggcga gcggatccgg gcctgcgcga aggacctgcg gatcagcccg gccacgctct 66060
tccacgcggg ctgggccctg gtcgtggcgg cctgcgcggg ccgcgacgac gtggtcttcg 66120
gcaccgtcat gtcgggccgc ctccagggcc cgcgcggcat cgagcgcatg ctcggcaact 66180
tcatcaacac cctccccgtg cgcgtcgacc tgaccggggt gagcgtgcgc gacctggtga 66240
gcgccaccga ccggaccctg cgcgacctgg tgcgccacga gcagaccccg ctcgccgtcg 66300
cccacggcca cagcgccgta ccgccggaga cgccgctgtt caacgcgatc ctgaactacc 66360
ggcacctgga gtccgacgac cgcatcgacg acagcgagct ggagcgcgcg ggcgtcaagt 66420
ccctcgcggg cgtcatcgag cgcagcaact accccatcgc cctgtccgtc gacgacctcg 66480
ggcactcctt ctcgctcgac gcgcagatcg accgggccca ggacgccgag ctggtcatcg 66540
gctacctgga aaccgccatg gagcgcctcg tcgacgccct caccaccgag ggcgcggagc 66600
ggcgcccggc cctggacctg cccgtcctga gcgacgccgt acgccaccag gtgctcgccg 66660
ggtggaacga ggcccccgcc gccgagccgg tgcagcggtg tctgcacacg tggttcgagc 66720
ggaccgccgc ctccaggccg gacgcggtgg cggtggagtt cgaggaccgt cgtctgtcgt 66780
acggggagct gaacgcgcgg gcgaaccgtc tcgcccggca tctgcgcggc cttggcgtgg 66840
gccctgacgt cctcgtcgcc ctgtgcctgc cgcgcagcga acacctcgtg gtggccgtgc 66900
tcgcggtgct caaggcgggc ggcgcgtacg tgcccgtgga cccggcgtcc cccgcggacc 66960
ggatcgcgca catcctgacg gacagcgcac cccgcgtcct ggtgacggac ggcgcgctgc 67020
ccgagggcct cgccgtcccc gccatccccg tcgtggacgt gcgcgcggac gccgaccagt 67080
gggcggcccg cgccgccgac gacctgtcgg tgccggacct cacgccgtcc gccatggcgt 67140
acgtgatcta cacctcgggc tcgaccggag tgcccaaggg tgtggtcgtc gaacaccgca 67200
atgtggtgcg gctgttcacg tccacggacg actggttccg cttcggcgag cgcgacgtgt 67260
ggaccctgtt ccactccttc gcgttcgact tctcggtgtg ggagatctgg ggtgcgctcc 67320
tgcacggcgg ccgcctcgtg gtcgtaccgc aggccgtcac gcgcagcccg gaggacttct 67380
accggctgct gtgcgagtcg ggcgtgacgg tcctcaacca gaccccgagc gccttccggc 67440
agctgatcgc agcccagggc gaggaccccg agccgcacat ggtgcgcgtg gtcgtcttcg 67500
gcggcgaggc cctggaggtc gcctcgctca agccgtggct gggccgcccg gtcaacaaga 67560
gcacccagct ggtcaacatg tacggcatca ccgagaccac cgtgcacgtc acctaccacc 67620
cgctcaccga ggccgacctc gaccggcccg tcagccccat cggccgccgc atcccggacc 67680
tgcgcaccta cgtcctggac ccgcacggcc gccccgcgcc catcggcgcc gtgggagagc 67740
tgtacgtcgg cggcgagggc gtggcccgcg gctatctgaa ccggccggag ctgtccgccg 67800
agcggttcct ggacgatccg ttccgcgagg agccgggcgc gcgcatgtac cgctcgggcg 67860
acctggcgcg ctggctgccc gacggctccc tggagtacct gggccgcaac gacgaccagg 67920
tgaaggtccg cggcttccgg atcgagctgg gcgagatcga ggcccgcctc gccgaacacc 67980
cggccgtcca ggacgcccgc gtcctggtgc gcggctacga cgaccaggac cagcgcctcg 68040
tcgcctacgt cgtcccgtcg gcggagcacg cgccggccgt ccgtgaactc ctgcgcctgg 68100
accgcaccga gccggaagca ctcgagcgga cctacgaact gcccaacggc atgacggtgt 68160
tccagcagaa caggagcgag accgacttcg tctacgacga gatcttcacg cacctcgaat 68220
acctgcggaa cggcatcacc atcgaggacg gcgacaccat cctcgacgtg ggcgccaaca 68280
tcggcctgtt cacgctgttc gcgggcagcc gctgccccgg cgcccggatc cacgccttcg 68340
agccgatccc accggtcttc gactcgctgc gccgcaacgt cgcgctccac ggcctcaacg 68400
ccaaggtgca cgcctgcggc ctcgccgccg aggcgaagga ggagaccttc accttctacc 68460
gccacaacac ggtcatctcc tccagcgtca ccaccgccga acaggcccac gacctggtgc 68520
gctcctacct gcgcaaccag gaggagctga ccgaggcggg cgcggccgac gccaccgccg 68580
gggacgacct cgtcgacgcg gtcgtcgacg cccgcctcga cagcgagcag ttcacctgcc 68640
ggctgcggac cgtctcggag atcatcgcgg aggagtcgct cgaccggatc gacctgctga 68700
aggtcgacgt ggagaacgcc gagtacgagg tcctcaaggg catccactgg cgcgactggc 68760
ccaagatccg ccagctcgtc gtcgaactcc acgacgtcga cggccagttg gagaaggtcg 68820
tcaccctcct caaggccctc ggctacgacg tcgtctgcga acaggacaac cgcctgctgc 68880
gcaacacgac cctctacaac gtctacgccc gccgcgccga aggccaggac gcgcggcgcg 68940
cggccgagcc cgccaccccg gccccgcgct ggtccggccg ggccgccctg ctcgccgacg 69000
tacgcgacag gctgggcgcg gccctgcccg agtacatgat cccggcggcg cacgtcctca 69060
tcgaagagct gcccctgacc cagaacggca agctcgacca gcgggccctg cccgcccccg 69120
aggaccggca gcggcccgcc gggcgccgcg tcgcgccccg caccgaggcc gagcggaccg 69180
tcgcgggcgt ctgggccgag ctgctgcgca ccgacgccga cgccctggac gtcgacagcg 69240
acttcttcgc cctcggcggc aactcgctgc tcgtcacccg cctcgtcaac cgcctcgccc 69300
aggcgacggg cgccgaactc accgtccagt ccgtcttcga gggcccgacg ctcgccgcga 69360
tggccgccga gctggagcgc cgcgcccccg gggcgcccca gggcgaggcg ctcgacgtcg 69420
ccgcgatcct ggagggcatc gacttgatcg agaacatgag cgaagaagag ctggacgcgt 69480
tggaaggccg gatcaagtga ccacgacgac gccgatgagc accccgaaca acggcacctc 69540
cctcgacctg atccggaaga tcaagtcact gcccgccaac aagcagcgcg ccctcatcgc 69600
catgctgaag aagcagggcg tcgacctgtc cgccctggag gcgatcggcc cccgcccgca 69660
caccggggac gagccggtcc agctgtcctt cgcccagcag cgcctgtggt tcctcgcgca 69720
gttggacggc accagcgcgt actacaacat cccgatggcc atgcgcctga gcggaccgct 69780
cgaccggccc gccctgctgc gcgccctgga gacgatcgtc cagcgccacg aggcgctgcg 69840
cacccgcttc gtcgagcgcg acggcgtgcc gtaccaggag atcggcgacg gccgcgactt 69900
cacggtcggc gaggaggagc tggccgaccc cgcccagctg ccgtcgatct gcgagcgcga 69960
ggccgtggcg cccttcgacc tggcccgcga ctcgctgatc cgcgtccgtc tgctccgcga 70020
gtccgagcac gcgcacgtcc tgctcgtgac catgcaccac agcgtctccg acggctggtc 70080
gctcggcgtg ttcttccgcg agatggtcac cctgtacgag gcgttccagg cgggcgaccc 70140
ggcgccgctc gcgccgctgc ccatccagta cgcggactac gcgcactggc agcgccagtg 70200
gctcgtcgac gaggtgcagg accgccagct cggctactgg acgcgccagc tcgacggcgt 70260
cgacccgcgc ctgcccctgc ccgccgaccg cacccgcccg gcgatcaaga cctacgaggg 70320
cgcgcacgag cgcttccacc tgcccgagga gctgctgcgg cagctgaagg ccctcgccga 70380
gcggcacgac gtcacgctct acatgacgct gctgtccgtc tacgccctgc tgctgcaccg 70440
ctacagcgag cagactgaca tcgccatcgg cacccccgtc gcgaaccggc agcgcatcga 70500
gtccgagggg ctcatcggct tcttcgccaa caccctggtg atgcgcgccg acctgtcggg 70560
cgacccggcc ttcaccgagc tgctcggccg cgtcaaggac gtcgcgctac aggccttcag 70620
ccaccaggac gtgcccttcg aagcagtcgt cgacgcgctg cagctggagc gcagcctcag 70680
ccactcgccg ctgttccagg tcgcgttcgt cctccaggag gcgcacaccg accgcgaggt 70740
gcgcctgggg aacctcgacg tctccctcat cgagttcgac ttcgacatca ccaagttcga 70800
cgcgacgctc gacctgcgcg agacccccga cggtctgatc ggcgccatcg agtacaacac 70860
cggcctcttc gaccgcgaca cggtccggcg cttcgtgcgc cactacaccg cgctgctcca 70920
cgccgtcgtc gccgcgccgg acgagcggct ctcccggctc agcaccctcg acgccgacga 70980
gcgccgccag gtgctcaccg agtggaacga ggtgcccgcg gcggcgcccg ccgagcggtg 71040
tctgcacacg tggttcgagc ggaccgccgc ctccaggccg gacgcggtgg cggtggagtt 71100
cgaggaccgt cgtctgtcgt acggggagct gaacgcgcgg gcgaaccgtc tcgcacggca 71160
tctgcgcggc cttggcgtgg gccctgacgt tctcgtcgcc ctgtgcctgc cgcgcagcga 71220
acatctggtc gtggccgtcc tcgccgtcct gaaggcgggc ggcgcctatg tgccgttgga 71280
ccccgcgtcc cccgccgacc gcctcgcgca cgtgctcgac gacagcgccc cccaggtgct 71340
cgtgaccgac ggaccgctgc ccgagggcct cgccgtgccg tccgtcccgg tcgtggacgt 71400
acgcgcggac gccgaccagt gggccgccct gtcggccgcc gacgtcaccg gcacgggcgt 71460
gggccccgcg cacgccgcct atgtcatcta cacgtcgggc tcgacgggcg tgcccaaggg 71520
tgtggtcgtc gaacaccgca atgtggtgcg gctgttcacg tccacggacg actggttccg 71580
cttcggtgag cgcgacgtgt ggaccctgtt ccactccttc gcgttcgact tctcggtgtg 71640
ggagatctgg ggtgcgctcc tgcacggcgg ccgcctcgtg gtcgtaccgc aggccgtcac 71700
gcgcagcccg gaggacttct accggctgct gtgcgagtcg ggcgtgacgg tcctcaacca 71760
gaccccgagc gccttccggc agctgatcgc agcgcagggc gaggacgcgc ggccgcacgc 71820
cctgcgagcc gtggtcttcg gcggcgaggc cctggaggtc gcctcgctca agccgtggct 71880
gcgccgcccg gtgaaccagg gcacccagct ggtgaacatg tacggcatca ccgagaccac 71940
cgtgcacgtc acctaccggc tgatcaccga ggccgacgcg gaccgcaccg tgagccccat 72000
cggcgagcgc atccccgacc tgtgcaccta cgtcctcgac ggacacggcc agccggtacc 72060
ggtgggcgtc gtcggggagt tgtatgtggg cggcgcgggt gtggcccgcg gctacttgaa 72120
ccggccggag ctgtccgccg agcggttcct ggacgatccg ttccgcgagg agccgggcgc 72180
gcgcatgtac cgctcgggcg acctggcgcg ctggctgccc gacggctccc tggagtacct 72240
gggccgcaac gacgaccagg tgaagatccg cggcttccgg atcgagctgg gcgagatcga 72300
ggcccgcctc gccgagcacc ccgccgtcca ggacgcccgc gtcatcgccc gcgaggaccc 72360
ccccggcgac cggcaactcg tcgcctacac cgtcctgcgc cccggcgccg acgaggccga 72420
ccaccgcgcc gacctcgccc gccacctgcg caggaccctg cccgactaca tggtccccgg 72480
cgccttcgtg gccctggacc gcctgcccat caccggcaac ggcaagctcg accgcaaggc 72540
cctgcccgca cccggcatcg aggccttcgc gcagcgcgcc tacacggcgc ccaccaccgc 72600
caccgagcgg acgctcgccg ccgcctgggc cgaactcctc ggcttcgacg aggaccgcat 72660
cagcgcgcac gacaacttct tcgcgctcgg cggtcactcc ctgctcatca ccgtcctcat 72720
cgcccgcctc aaggagcgcg gcctggacgt cgccgtgcgc agcgtcttca gcagccccac 72780
gctcgccgac ctcgccgccg acatcgaccg cgcgggaccg gccgccaccg gctacgccgt 72840
gcccgcaccg gcggtcccgg agggctgcga gcggctcacc cccgagatgc tgccgctggt 72900
ccgccttgac caggccgccg tcgacgccgt cgccgcccgc gtgcccggcg gcgccgccaa 72960
cgtgcaggac gtctacccgc tcgtgccgtc gcaggagggc atcctcttcc atcacctgat 73020
ggaccccgcc aacgacccgt acgtcatccc catcctgctc accgcccccg accggcggac 73080
gtgcgacgcc ttcgtggacg ccctgcaggc cgtggtggac cggcacgacg tgatgcgcac 73140
ggccgtcgtc accgaaggcc tcggcgagcc cgtacaggtg gtcctgcggg acgtccgcct 73200
cgacgtggag cggcgcaccc tcgacgccgc cgactccgac gccgcggcgg agcaggcccg 73260
cgcctggctc gcggacccgg ggacgatcac gctcgaccgg gcaccgctgc tgcggctcgc 73320
cgtcgccgcc gacccgcact ccgcacggca cttcctgctc ctgcgcgtcc accacctcat 73380
cgaggacgcg acctcgctgc gcatcatcct cgaagagctc gccgcccaca tggcgggccg 73440
cgccgacgaa ctgcccccgg ccccggccta ccgcgacttc gtcggccaca ccctgcacca 73500
gctcgccgcg aacgacgccg aggcgtactt ccgccgcgag ctgggcgacg tcaccgagcc 73560
caccacgccg ttccagctcg tcgacgtgca cggcgacggc agccgcgtgc gcgacctgcg 73620
ccgctccctg ccgcccggcc tcaccagccg cctgcgcgag caggcccagc ggctgcggat 73680
cagccccgcc gcgctcttcc acgccgcctg ggccctggtc accgcggcca ccggcgggcg 73740
cgacgacgtg gtgttcggca ccgtcctgtc cggccgcctc cagggcgtgc ccggcgtcga 73800
gcggatgctc ggcaacttca tcaacaccct gcccctgcgg gtccgcctcg ccgaccgcag 73860
cgtcaaggac ctggtgtccg ccgtggacgc ctccctcaag gaactcatct cgtacgagca 73920
gagcgccctg accctggccc agcgctccag cggcctggac ggcgacgcca ccctgttcag 73980
ctcgatgatc aacttccggt acttcgagcc gcgccagggc gacctgggcc cggccaccct 74040
ggaggacctg ggcatccgct ggctgggctc cctggaccgc accaactacc cggtgggcgt 74100
gtccgtcgac gacaccggca ccgaactgtc cctgaacgcc caggtcgacg ccaccctctc 74160
gccggacgcc gtcctcggct acgtcgaggc ggcggtgtcc ggcctcgtgg acgcgctcgc 74220
cgccgacgac ggcgccggca cccgggcgct cgacatcgac gtgctcccgg ccgcggaacg 74280
cggccgcctg ctgaccgagt ggaacgacac ggacaagccc tacccggacg accactgcct 74340
cttcgaactc ttcgaggagc acgtccggct gcgccccgac gccgtcgccg tcgagcacgg 74400
cgagcagcgg ctgacctacg ccgagaccaa cgcccgcgcc aaccgcgtcg cgcactggct 74460
gcgcgagcag ggcgtcggcc ccgacaccct ggtcggcctg tgcgcccgcc gctccccgga 74520
gctcgtgacc ggcctgctcg gcatcctcaa ggccggcggc gcgtacgtcc ccatcgaccc 74580
ggactacccc caggagcgca tccgcaccct ggtggccaac tccggcgtcg gcatcgtgct 74640
cagccagtcc cacctgccgt ccgagccgct cgaaggcgcg gacgggggta agggacccct 74700
ggtcgtccac ctggacaccg gcgaacgcgc cggggacggc acgcagctgc tcgccggccg 74760
ccccgagcac gacctgacgc gcgccgaact cggcctcacg cccgagcacc tggcctacgc 74820
catcttcacc tcgggctcca ccggcgtccc caagggcgtc ctcgtggaac agcgcggcgt 74880
cgtccgcctg gtgcgcaacc cggactactt cccgacggac cccgacaccg tcgtgctgca 74940
ccactcctcg atctcgttcg acgtcggctc ccaggaggtc ctcggcccgc tgctgtgcgg 75000
cggacggctc gtcctgcacg acggcgactc caaggacgtg ggcgccctcc tggaccgcgc 75060
cgagcgctcc ggcgtcacga tgatggccct gtccgcggcc ttcctgcccg cgttcgccga 75120
ggccgcgcag gggcggcggc tgccgctgac gtacctgggc gtcggcggag aggccttctc 75180
cgccaaggac gtgcgccgcc tgtacgcggc ccaccccggc ctgaccgtcg tcaacgccta 75240
cgggccgacc gagaacagca tcgcctccac ctgccacgtg atcccccggg acatcgccga 75300
ggacgcggtc atccccatcg gcaggcccat cgcgcagtcc accgcgcacg tgctcgacgc 75360
gcatctgcgg cccgtgccgc tcggcgtcgt cggcgagctg tgcgtgggcg gcgcgggcgt 75420
cggccgcggc tacctcggca accccgagct gacgaaggag cggttcgtcg ccgacccctt 75480
cgccgcgcgg cccggggccc gcctgtaccg caccggcgac ctggtgcgcc gactgcccga 75540
cggcaccctg gagttcgtcg gccgcgtcga cgaccaggtg aaggtccgcg gcttccgcgt 75600
cgaactcggc gagatcgaga acgcgctgca ctcccacccg gccgtgcgcg gcgccgtcgt 75660
caccacccgg gccagcggcg agacgaagaa gctcgtcgcc tacgtacggc ccacgaccga 75720
ctggctggac acggccgcgc gcgagcagaa cgccgaccgc ctggagcagt ggcaggacct 75780
cttcgaggac cagtacggca ccgacgcgga cgagcaggcg aacgccaccg gcaccgggac 75840
cggcaccggc accagttccg gctccgggga ctccggggac tccggggacg acctcaacct 75900
ggtcggctgg aactgcagct acaccggcga cgccatcccc gagcacgaga tgcgcgagtg 75960
gatcgacggc accgtccagc ggatcgagga gctgcggccc cgcaggctcc tggaggtcgg 76020
ctgcggcacg ggtctgctgc tgttccgcta cgccggagcc tgcgaggccg tgcacgccgt 76080
cgacatctct gcctcggccc tggccggagt gcggcgcggc gccgaccgcc gcggctggtc 76140
gcacgtcacc ctcgcccagg gcgacgcccg gtccgtgacg ctgcccgaag gcaccgacgg 76200
cacggagaag ttcgacaccg tcgtcatcaa ctccgtggcc cagtacttcc cgaaccggct 76260
ctacctggaa gaggtcatcg agcggctgct gccgctcgtc gccgacggcg gccggatcct 76320
cgtcggcgac gtcaggaacc tcgacctgtt ctccgcgcac gtcacggccg tcgagcgcag 76380
ccgcctgtcc gcgcgcaccg ccgtcgccgc cctggcccgc caggtgcagc gccgccgcca 76440
gcaggagacc gaactcctcg tcagcccgag ctacttcgcc gggctgcccc ggcggttcgc 76500
ggacatcggc tccgtcgaca tcgccgtcaa gcgcggcacc ggcggcaacg aaatgctcag 76560
ctaccgctac gacgtcgtcc tcaccaaggg cccggccgcc gacgaggacg acctgccgtg 76620
gctgaccgcc accacgcccg acgagctgcg cgccctgctc gccgacggcg gccgcccgcg 76680
gttcggcgtc acgggcctgg acaacccgcg cgtcgccgac gacgtccggg ccgccgcgag 76740
cctgcgcggc accaccggac agcagcacgt cgagccgctc ggcgcgagcc gcctcacgga 76800
cgccgcggtc cagcgggtgc gcgacctgga ggacgtcctc acgtacgccg agaagctcgg 76860
ctaccaggtc gccgcgacct ggtcccagga ccgcctcgac ggcctggacc tggtcctcgc 76920
caaggggacg cggccgaccg cccgcgcccg ggccgcgtac ggcgcgaccc acctggcgaa 76980
cgtgccgcag atcgccacca ccgggcaggc cctgacccgc accctgaagg accacctggc 77040
gggcaggatc cccgagtaca tggtccccag cgtcttcgtc gccctcgaag agctgccgct 77100
cacccccaac ggcaaggtcg acaagcggtc cctgcccgcg cccgacgagg ccgacgtgca 77160
caaggaggtc tacgtcgcgc cgcgcaccgc caccgagcgc gtgctgtgcc gcctcgtcca 77220
ggacgtcctc gacctcgacc gcgtcgggct ccaggacggc ttcttcgacc tcggcgggca 77280
ctccctgctc gccacccggc tcaccatccg cgtcaagcag gagaccggca aggagcttcc 77340
gctccagtcg atcctcgccg gcgcgaccct cggcgaactg gccgccgcac tcgacgcggc 77400
ggacggcggc acgtccgacg gggccgtccc gctggtgccc gtcaccgggc ccggcgagga 77460
gagcccgctc tcctgccagc agagcgagct gtggttcctc aaccagcgcg cgcacctcgg 77520
ctcgtcgtac gacaacgtgc agatggccta ccgcgtcatc ggcccgctcg accggcaggc 77580
atacgcccgc gccttcgaag ggctcgtggc ccggcacgcc gtgctgcgca ccagctacct 77640
gcggcgcggc gacacctacg tccagaaggt gaacgacacc accggcttcg ccgtcgcctt 77700
cgaggacgtc acgggtgaca gcgcggtcac cgagttcctc cgcgccgaac ggccgcgacc 77760
gttcgacccc gcggaccggc acatgctgcg cgtgcacatc ctgaccctca cgccgtacga 77820
gcacgtcgcc gtggtgaccc ggccctgggg catcttcgac ggctggtcga ccggcgtgtt 77880
catcgccgag ctcaacgccc tctaccaggc gctgagccgc ggcgacgagc cgtcccttcc 77940
cgaactgccc gtccagtacg cggacttcgc gcactggcag cgccgcacct tcgacgccga 78000
cgcccgcgcg cggcagcagg cctactggcg cgcccagctc gccgacctgc cgtcgtgcac 78060
cgcgctgcgc accgactacc ggcggcccga ggcgaagtcg taccagggct cctcggtcga 78120
ggtgaacgtc cccgccgcgg tgctcgacca gctcaagcgg gtcagcaagg agcgcggcgg 78180
cacgctctac atgacgctcc tttcggcctt cgcgacgctg ctcggcgccc acaccgacga 78240
ccgggagctc gccatcggct cgccggtgac caaccggccg cggccggagc tcgaacgcct 78300
cgtcggctac ttcatcaacg tcctggtcat gcgtctggac gtgcggcccg agcaggcctt 78360
cgacgacctc ctcgcgcagg cgcagcgggt caccgcggcc gcccacgagc acaaggaggt 78420
cccgttcgcc gatctcgtgc gggacctggt gcccgagccg gacccggcgt attcgccgct 78480
gttccaggtg atgttcaacc tggtgcccgc cgtcgaggcc gcgccgcccg gcgccgcgga 78540
ccccggcgcg ctcggcttcg tgcccctgcc caccgacagc ggcacggcga agttcgacct 78600
caacctcgtc gtccgcgaga cccccgacgg cctgcgcggc tacctggagt acagcaccga 78660
cctctacgcc aggagcacgg tccggtccat ggcggcgacc tatgagaggt tgctgctcaa 78720
gatcgtcacg cagcccggcg cgagcctcgc acggctgcgc gaggcggcgg cggacggcgg 78780
tgccggatga gcaccaccca cgccgcggcc gaccccgacc accccacccg tcccacccca 78840
cccagcgaaa gcgcacacat gaccaaggaa aagaccttca ccctgatcgt cgacgccgtc 78900
cgcgagatcc tcccggaact cgcagaccac gacttcgccg agaccgacac cctggacgcg 78960
ctgggcgcca actccatgga ccgcgcggag atcgtgatga ccgtcctgga ggagatggac 79020
ctggacatcc ccctggtcga cacccacggg ccgcagaacc tgggcgagct cgcgcggcac 79080
ctcagcgaca cggcagcggt caaggccggg tgacgtgagc gactccgcag ggctcgtcgt 79140
caccggtctc ggcgtcacca ccgccgtggg ccggggcaag gccgacttca cccgggcact 79200
gttcgcggga gagcaccgct tcgccgtcat ggaccggccg gggcggcagt ccggcacccg 79260
cttcgtgggc gccgagctgc ccgccccgcc gccacctgcc cggctcggcg cccgtgagct 79320
gcgcaccgcg tccctcaccg gacaggtcgc cctcgccacc ctcgaagagg cgtggaccga 79380
ggcgggcctc gacggctacg acccggaccg ggtcgggctc gtcatcggcg gcagcaacct 79440
ccagcagcgc gaactcgtcc gggcccagga ccggcaccgg gccaagccgc acttcctgcg 79500
gcccagctac ggcctgtcgt tcctggacac cgacctgtgc ggcctgtgca cgagcgcctt 79560
cgggatccgc ggcttcgcgc acaccgtggg cggcgcgtcg gccagcgggc agctcgcggt 79620
catcgaggcg gccgaggccg tggcctcggg ccgcgtcgac gtgtgcgtcg ccctgggcgc 79680
gctcgccgac ctgtcgtact gggagctgct cggcctgcac gcgatgggcg ccatggcggg 79740
cgaggaccac gccgacgcgc ccgccgaggc ctgccgtccc ttcgacaagg cacggtccgg 79800
cttcgtctac ggcgaggcct gcgccgccct ggtcatcgag cgcgggggcg cccgcccgga 79860
cgcccccgcc ccctacgcgc ggctcagcgg ctggtccgtg cgcctggacg gcaaccgcaa 79920
ccccaacccg tccctggcgg gcgagaccga cgcgatccgc caggccctgg accgcgccgg 79980
gctgagcgcc cgggacatcg actacgtcaa cccgcacggc accgcgtccc cgacgggcga 80040
cgagaccgaa gtggccgcgc tcaaggcctg cggcctcacc cacgcggccg tcaacgccac 80100
caagtcgatc accggccacg gtctgacggc cgccggagcc gtcgaggcgg ccgcatccct 80160
gctgcagatg cggcacgggc ggctgcaccc gacacgcaac ctcaccgcgc cggtcgacga 80220
cgccccgcgc tgggtgcgcg aggcggccgt cgaggccgac atccagcact gcctgagcct 80280
gagcatgggc ttcggcggca tcaacaccgc actgtgcctg agcgcgtgcg ccgcatagag 80340
agcagaacag cgaaccccat gtcccgcgtc ggtatcgaag cgatgaacgt gttcggcggc 80400
tcggccgtgc tcgacgtcat gcagttggcg cggcaccgcg agctcgacct cgcgcgcctg 80460
aacaacctcc tgatgaagga gaagacggtc gcgctgccct tcgaggaccc ggtcaccttc 80520
ggggccaacg cggcccggcc gctcctcgac cgcatgagcg aggaggagaa gggccgcatc 80580
gaactcctca tcacctgcac cgagtcgggc ttcgacttct ccaagtcggc gagcacctac 80640
ctccacgacc agctgggcct gagccgcaac tgccgtatgt tcgagctcaa gcaggcctgc 80700
tacgcgggca ccgcggggct ccagatggcc tgcaacttca tcctctcggg cacctcgccc 80760
ggcgccaagg ccctggtgat cgccaccgac atctcgcgct acatcctgga ggacggcgac 80820
gacgtggccg cgcaggactg ggcctacgcc gagcccagcg gcggcgcggg cgcggtggcc 80880
ctgctgatca gcgccgagcc gcacgtcttc cagctcgacg tcggcgccag cggcacgtac 80940
ggctacgagg tgatggacac ctgccgcccc gccccggaca gcgaggcggg cgacgtcgac 81000
ctgtccctga tgtcgtacct ggactgctgc gagcaggcct accgcgccta cgaggccaag 81060
gtggagggcg cggactaccg cgacaccttc cagtacctcg ccttccacac ccccttcggc 81120
ggcatggtca agggcgccca ccgcaccatg atgcgcaagg tcgccaaggc caagggcgcc 81180
gagatcgccg aggacttcga gcgccgcgtc gcgccagggc tcggctactg cggccgcgtc 81240
ggcaacatca tgggcgcgac ggtcttcctc tccctcgccg gcaccatctg caacggcgac 81300
tactcagacc cgcggcgcat cggactgttc tcgtacggat ccggctgctg ctcggagttc 81360
tacagcggcg tcgtcacccc ggacggcgcg gagcggctgc gggccatggg catcgaggac 81420
cacctcgacg cgcgctacca gctctccctg gacgagtacg accagctgct tcgggagagc 81480
gcgttcgtcc gcgtcggcac ccgcgacacc gtcgtgaacc aggacttcgt cgccaggacc 81540
gccccggccg cccggaccgc gcagggcgcc gggggcggct cgccgcgcct cgtcctgcgc 81600
gcgatcaagg agttccaccg ggagtacgca tggatcgact gacccgctcc gcctactcca 81660
ccctgcgcgt ccgcgaacag ggcagcgtgc tcttcgcgca gatccaccgg cccgaggcgg 81720
gcaacgccat caacgccacg ctcgtccacg agctcgacga cgtcttcgcg cgcgccgccc 81780
gcgcggagca caccaccgtc gtcgtcctcg aaggactgcc cgaggtgttc tgcttcggcg 81840
ccgacttcgg cgtgatcagc gacgcggcgc gcacgggcca ggacacgtcc ttcgaccccg 81900
agccgatgtt cgagctgttc cggcgcatgg cctacgccga cgtgctcacc gtcgcgcacg 81960
tgcgcggcaa ggccaacgcg ggcggcgtcg ggctcgtggc cgcgtgcgac gtggtgatcg 82020
ccgacgacag cgccaccttc agcctctccg agctgctctt cggcctgatc ccggccgtcg 82080
tgctgccctt cctgatccgc aggaccggct tccagcgcgc ccactacctc gccgccacca 82140
cccagaccgt cgacgcccgg caggcccacg agtgggggct cgtcgacgcg ctcggcaccc 82200
ccagcgaggc gctcctcaag cgccacctcc agcgcctggg acggctctcg aagaagggcg 82260
tcacgcgcta caaggcgtac ctgcgcgagc tgtccccgct caccgagcac accaaggacg 82320
tcgcgctcgc caccaaccgc caggtcttcg gcgaccccga caacgtgcgg gccatccggc 82380
gctacgccga agagggcgtc ttcccctggg agaccgcgac gccggacgcc accgcgacgc 82440
cgaacccgtc cccgcagcct tccccgccgc agtccccgca gccgtccccg agcgagacca 82500
ccgtggaacc acagcaccag cgggccaccg ccccgccgcc cgccctctcg ccccgcgccc 82560
tcggcagccc gcgcttccgc gcggcgcacg gcgtcgacta cgcctacgcg gccggggcga 82620
tgtacaaggg catcgcctcc gtcgacctgg tcaccgcgct cggcaacgcg ggcatgctcg 82680
gcttcttcgg caccggcggg ctcgccctcg acgaggtcga ggacgcgatc atccgcatca 82740
agaagggcct cgaccccggc cgcgccttcg gcatgaacct cctgaacaac ccggacgacc 82800
ccggccagga ggcccgcacc gtcgagctct acctgcgcca cggcgtgcgc tccgtcgagg 82860
cgtccgccta tctgcggccc acccccgcgc tggtccacta ccgcctcgcg ggcctcggca 82920
ccgacgccga aggacgcctc cgccaggacc accacatcat cgccaaggtg tcgcgcaccg 82980
aggtcgccga gcacttcctg cgcccggccc cggccccgct ggtccgccgg ctcctcgacg 83040
acggactcat cacccccgag caggccgaac tcggcgcccg cctcccgctg gcgcaggacc 83100
tgtgcgtcga ggcggactcc gcgggccaca ccgacggcgg caacgcctac gtcctgatgc 83160
ccgccatgcg cgccctgcgc gaccgcgtga cgcgcgagca gggctactcc gaagagggcg 83220
gcgaggccgc cgtgcgcatc ggcgccgcgg gcggcatcgg cacccccgaa gcggccctcg 83280
cggccctgac cctgggcgcc gacttcctcg tcaccggctc catcaaccag tgcaccgtgg 83340
aggccgggac cagcgacgcg gtcaaggacc tcctccagga cctcggcgtg cacgacaccg 83400
agtacgcgcc cgcgggcgac atgttcgagg tcggcgcccg cgtccaggcg gtcaggaaga 83460
gcacgttctt ccccgcccgc gcccagaagc tgtacgacct ctacgtacgg cacgactccc 83520
tcgacgacct cgacccgcgc acccgggcga ccctggagaa caagtacttc aagcgctccc 83580
tcgacgaggt gtgggaggag acccgcgccc acctggcacg gcgccacccc gcccggctcg 83640
ccgaggtcga gcgcagcccc aagcagaaga tggcccacgt cttccgctgg tacttcgtgc 83700
actccacgcg cctggcgctg cgcggcgccg accagcgcgt cgactaccag atccactgcg 83760
gacccgccct cggcgcgttc aacacctggg tgcgcggcac cgacctggag ccctggcgcg 83820
gccgcagggt cgacgtcatc gccgaacggc tgctccggga gaccgcggcc ctgctcaccg 83880
agcgcctggc cgcctacgcc gccctggccg ccgacagcac accgccctcc tccgacccca 83940
cccccgacac cgcccccggc ggaccggcac ctctcgcgac ggctgagtga tcacatgact 84000
tccgtgtacg tattccccgg gcagggctcc cagcgcaagg gcatgggcaa ggacctgttc 84060
gagaagtacc ccgacctcgt ggcccgcgcg gaccggctgc tcggctactc gctgcgcgac 84120
ctgtgcgtcg acgaccccga ccgggtcctc aaccgcaccg agtacaccca gcccgcgctc 84180
tacgcggtca gcgccctgca gtacctcgac cacatcgact ccggcggcgc cccgcccgcc 84240
gtcgtcgccg ggcacagtct gggggagtac agcgccctgt tcgccgcggg cgccttcgac 84300
ttcgtcaccg ggctcgacct cgtgcgcagg cgcggcgagc tgatgagccg cgcccccaag 84360
ggcgcgatgg ccgccgtggt caacctcgac caagagcgcg tcgcggagat cctggccgcg 84420
ctgccgcact ccggcatcga catcgccaac atcaactccc ggcagcagtg catcctctcc 84480
ggcacctacg acgaggtcca cgccccggac gtccgcgagg cctacaccgc ggcgggagcc 84540
aggttcatcc cgctcaacgt gagcgcggcc ttccactcgc gctgcatgac cgaggtccag 84600
gaggagttcg cgcgccatct gccgggcgtc gcgttccgcc cgctgcggat ccccgtgatc 84660
gccaactgca cggcccggcc gtacccgacg accggctact ccgacctgct ggtgcggcag 84720
atatcgagcc ccgtgcggtg gtacgagtcc ctctccctgc tccttgcgcg cggccacgac 84780
gagttccgcg agatcggccc cggcgacgta ctcaccaagc tcaccgccaa gatccgcgag 84840
gagccgctgg ccgtcgagga accgccggcc gccgaggcgc ccgccgcgcc ccaggcgccc 84900
ccggcccccg ccgcgccccg cccggccccg caccggaccc tgcggcgccc cgaggtcgtc 84960
ttcatgtacg gcggccaggg cacgcagtac taccgcatgg ggcaggagct gtacgacacc 85020
cacccggcgt tccgggacgc catggaccgg tgcagcgcgc tgtacgaggc ggcacagggc 85080
acctccctcg tcgccgcgat gcacgacagc acccggcgcg gccaggactt cgacgacgtc 85140
ctgcacacgc acgcggcgct ctacagcgtc ggctggagcc tcaccgaggc cctgcgcgcg 85200
gagggcttcc accccgacgc ggtcctcggc cacagcctcg gcgagtacgt cgcggccacc 85260
gtcgccgggg cgatgtcctt cgaggacggc ctcgacctcg tgatgaagca ggcccacctc 85320
ctcgacctgc gctgccgccc cggcggcatg ctgagcgtcc tcgccccgcc ctcgctctac 85380
cagcggcggc gcgacctgtt cgccggactc gccctggcgg gcgtcaactt caccggcgac 85440
accaccggca acttcgtcgt cagcggcgag gccgagcgcg tcaccgaggc ccgcgccgcg 85500
ctcgaccggg aaggggtgat cgccgtccgc ctcccggtgc gccacggctt ccactccggc 85560
ctcctcgacg acatccggca ggagtgccgg agcctgggac gcgcggtcgc ggtgaactcg 85620
cccaccctgc cggtgtattc gtgcgcgtac gcggcagagc tggacggcgc ggcgctgacc 85680
ggctgggacg actacgcgtg ggacgtcgtc cggggccgcg tgcgcttcga cgagctgatg 85740
gccaccgcgt tccgcgaccc ggcgcgccac tacttcgtcg acctgagcgc cagcggctcc 85800
ttcgtcaact tcctcaagca cggctacggc cccgactacc ggggcgcgtt cgcgatcaac 85860
cagttcggca acaacacggc gtcgatgcgc cgtctgcgcg agggcctgga gcaggccgtc 85920
cagcccgccc tcgtctgacc ccgggaacgg caaagggggc tcaccgccgc ggcggtgagc 85980
cccctgacgc cttctcaggc gggcactcgg atcaggccgg tcagccgacc gacaccggca 86040
gcgaggccac gccgcgcacg ttgatgcggc cgttccaggt cacgtcgccc gcgagggaca 86100
ggtccgggaa ccgcttcagc atccgctcga aggtgacgct cgcctccagg cgcgccaggg 86160
ccgcacccag gcagtggtgc gagccggagc cgaacgccag gtgggcgcgc gcgccttcgc 86220
ggtcgaggcg cagcgtgtcc gcgtcctcgc cccagcgcgc ggggtcgcgg ttcgcggagg 86280
cgagggcggc gaccaccatc gagcccgggg ggatctcgac gccgctgagc acggtcggtt 86340
cgagggtgat gcggcggctc gactgcaacg ggctgtcgta gcgcagcagt tcgtcgacgg 86400
cgttgggcat caggtccgcg tccgcgcgca gcgcggcgag ctgctcgggg tggcgaagca 86460
gcgcgtgggt gccgttggcg agcaggttca cggtcgtctc gtggcccgcg atgtacagca 86520
gctggatctg cgcgaccagc tcgtcgtcgc tgagcttgtc gccgtcctcc tcggcctcga 86580
tgagggccgt catgaggtcg tcggcggggt tgcgccgctt ccaggcgatc atctcggaag 86640
tgaggacggc cagttcggcg tccgcgttct cgatctcctg catgacggcc gggtcggcga 86700
cgggctcaag ggagcggacg atcgtgccgc tcagctcctg gatccgctcg tggtcggtgg 86760
gcggggcgcc cagcatctcc gcgatcaccg tgaacggcag cggcgacgcg agcgcgggca 86820
ccaggtccgc gccgcccgcc gcggcgatct tgtcgagcat gccgtcgacg agctcgccga 86880
tgcgcggcgc gagcgcctgg atcgacttcg gcgtgaacgc cttctgcacc aggcggcgca 86940
gccgggtgtg gtccggggcg tcccggtcga tcatcgagaa gccgtcgatg agcggagtct 87000
tgcgcgactc gtccttctgc cgcaggttct ccagcgcgcc ggagttcacg ttgcgcagtt 87060
cgaccgacgc gcccgagcgc agcagcccga acacgtcctc gtaccgggtg accacccaga 87120
accccagggg gtgcggatag accggggcga cttcgcggag cgtcgcgtac tgcgggtacg 87180
gattgtcggt gaacccctcg gcgaaggggt tgaacagcgg tatctgctgt tcctgaggga 87240
gagcgccccc ggtcatctcg tgctccttgt ggtggcaccg gctggaggga ccccccgacg 87300
gtggtccatg cggatccacc gcctcggccc tcggccccgg ctggatgaga gttcgcaggt 87360
cacagtagtg acgccgggag gaccggtgac acgtgaccag gatgagagca ggagagtacc 87420
cggcgtagcc gggccgacac taggccgtcc agtgggaggg gcgctccagc gggtggggga 87480
ccttcgtccg ggcgtcgccc cgcgcggcgt tcagctgggg ctgggtgagg aacagcgcgc 87540
cgcgcagatc cgcgccgcac aggttcgtgt cccgcatgtc cgcgccgatc aggtcggcgt 87600
cgcgcaggtc ggcgtccgac aggtcggccg cgatgagcag ggcgccgcgc atgctggcgc 87660
cgcgcagctt cgcgccgcgc agccgggagc ccatgaggtt ggcgccgcgg tggttcttct 87720
tgcggcccgg gaccgccgcc cgggccagtt cgctggcgcg gagcagcagc gggttcacct 87780
caccgcgcag cgcgtccacg tcgacggcga gcagcgtctc gaccgtgtcc cgggtgagcg 87840
cgtcgatccg ctcgtacgcg ccgcgcagct cccggtggac gggccgggcc gcggacaggt 87900
ccagggcctg cgcggtgtac ttcaggagct cctggagctg tcgtacgacg gggaagacct 87960
cgtacatcgc gcgggccgag tccggctcct cgcgccagct gacgcccttg aacgtgacct 88020
gggagacctt ctggcccgcg ccgaagcagt cgaagaccgt acagccgttg tagcccttgt 88080
cgcgcagccg ctcgtggatc ccgcagcgga agtcctcctg gaggcttccg cacggcgtgc 88140
cggcggactt gttcaccggg aagtccgacg agcgcgagaa gggcagcgcc acgcagcaca 88200
gaccgaagca gctcccgcag tcggcctgca ggtcgggctg ggcggcgtgc gaggtgcgct 88260
cggacaagac ggtggctcct gaggggcgtg cggcggcgtg cggtggtcgt acgcctccat 88320
tgtccctcgt acgtcgaccg cgacggtacg agggcccaag ggggcgcact cgggacggga 88380
gggccggtca ggtcacggac gggggcgcgg ggcgccccgg tcccgtgctc aggcctgcgc 88440
ggccttcgcc gccttctcgg cctgctccgc cttcttcgcc ttgaggcgga ccgtctcctt 88500
gcggacctcg gcctgcgtgg cgcgctcgcg ctccagccac tcggggcgct cttccttcag 88560
cgcgtcgatc tgctgcgtgg tgaggggctc cgtgacgccg ccgcgggcga ggcccgacac 88620
ggagacgccc agcttcgcgg cgacgaccgg gcgggggtgc gggccgttct ggcgcaggtc 88680
gcgcagccac tggggcgggt cggcctgcag ggcgttgagc tcggtccgcg agacgacacc 88740
ctcctggaac tcggcggggg tggcctcgag gtacacaccc agcttcttcg ccgcggtggc 88800
gggcttcatg gtctgggtgg agtggtgcga cgtcatagga ccagggtatc gagcgaatgc 88860
gcgaccgctg accacggcgg gcccgtcgcc gcccgcaccc tccggcgggt cggccgccga 88920
ctacgggcgg tagtctggcg aggtgacagg ctcggaagac tctcccgcgt tccggctcgc 88980
ctacgtgcca ggcgtgacgc cctcgaagtg ggtgcgcatc tggaacgagc ggctgcccga 89040
cgtccccctg accctcgccc aggtgcccgc caccgaggtc tgcgaggtcc tgcggaaggg 89100
cgatgccgac gcgggattcg tacggcttcc ggtcgacggg gaggacctca gcgcgatccc 89160
tctctacgag gagacgacgg tggtcgtggt ccccaaggac cacctcttcg cggcggccga 89220
cgaggtggcc gtggcggacc tcgccgacga gctggtgctg caccccctgg acgaccccct 89280
ggagtgggag cgtccgccgg gccgccccgc cctcgagcgc cccgccacga ccgccgacgc 89340
cgtcgagctg gtggcggcgg gcatcggcct gctgatcgtc ccccagtccc tggcgcggct 89400
gcaccaccgc aaggacctca cgtaccgcac gatcacggac gtccccacgt cccgcgtggc 89460
gctctcgtgg ccccaggagg ccacgaccga cctggtggac gacttcatcg gcatcgtccg 89520
cggccgcacc gtcaacagca cccggggccg ccgcgccgag cccgagccga aggccaagcg 89580
cccggagaag ggcggcgccc gacggcagca gcccgccggg ggcaagggcg gcggccgggg 89640
caccggcaag acggcgggca agccgtccgc caagaacgcg cgccggggct ccggcggccc 89700
gaagggcgtc aagggcggca agccgcgccg caggccgtag cgtcccgcgg tcccgctccg 89760
cgcgtcacca gggctggttc ggcaggaacg cgccggagcg cgccgactcc gcctcccgcg 89820
cccggtggga gtggaccagg gcccagcagc ccaccgccgc caccccgatg gcgaggacga 89880
ccaggtgcca ggtggagacc gtggcctgga tcgagctgcc ctccgggtgc gcggcgacgg 89940
tgatcccgag ggccagcggt acggccatcg cgagggccca gccgccgagc acggacgagg 90000
cgaggcggtg cggaagcacg agacccgccc agagcagcac ggcgagggtg ccaaggacgg 90060
ccaccgcgca gctcatgagc ccgggaacgg cgattcccgc ggccgtggcg cccgtggcgg 90120
cgcccgccgc cgcccggatc agccggcggc ggtcgaggga acgggcccgc ctcccgccgt 90180
gccgcgccag atgcacgacg gcgagcagtc cgacggctcc cgcaagcagg tagggcccgc 90240
tgttgagcca tgcgtcctgg tcgagttcgc gctggctctg ttggaagctg ttgatgacga 90300
atccgctggt cagggcgagg acgccactgc cggccaggag tccggcccag gtgcgcctgc 90360
tcggtgagac aagactcgcc caggagccga tgagcagccc caggaagggg aggtgggcga 90420
ggaccaggag ggcgttgagc accccgtccg ccccgaaggg gtaaccggcc gcgacggtgg 90480
cccagggggc gtcgggtccc gaggcgtcgg cggtgtgccc cgcgtcgatc caccacgtct 90540
cgaaggggcg cgcacggaag acgaggagtc ccggcccggt gagcacggcg tgccagttga 90600
gctggaacca ggacaggacc cagaggccga ccgtgccgag gccgaggagc cccggcagga 90660
cggggttcac gagggacgcg ggccgcgcgg cctgccgcca cggcagcgtg ggcggcggca 90720
cagcaggcgc gggcggcggg cgccgcggtg ccaccggggc cgcggccatc atggtggtga 90780
cgcggccctc cgcgatctgc cgcagctccg cggcggcctg cgcgacgtgc ggccgttcct 90840
ccgggttctt ggccagcagg gcgtacagca cggcccccag ggcgggcccg gcgcggcgcg 90900
acacgggcgg cgggtcggag agcaccgccg cgatggactc cacagcggcg ggccgggcga 90960
agggcgacgc gccctccagg gcgtggaaga gcgtgacgcc gagggcccag aggtccgtgg 91020
cgggcacggg cgccccgcgg atctgctcgg gcgccatgta ggccggggtg ccgaagacgc 91080
tcgtcgtgct ggtgacctcg ctggagagcc gggcgatccc gaagtcggcc agcttgaccc 91140
ggccgcccgc gaggagcatc acgttctcgg gcttgacgtc gcggtggatc acgcccatcg 91200
cgtgggcggc gccgaggacc tcggcgagct gcgcgccgat cgacgccacc cgggccggcg 91260
gcagggggcc ctcccgggcc acgagcgcgg ccagggtggt gccccggacg agctccatga 91320
cgatgacgac ctcggagccc gcgcgcacca cgtcgtagac ggtgacggcc ccggggtggt 91380
tgagcttcgc ggccgcgcgg gcctcccgca gcaggcgcgc ggtggccttg gtgtccaggg 91440
gcgccgcccc ctgcccggga ccgcgcacgt gtttcacggc gacctcgcgc ccgagcaggg 91500
tgtcgacggc ccgccacacc acacccatgc caccccgtcc cagctcctcg atcagctgga 91560
acctgccacc gaatggctgc ccgccctcaa ccat 91594
<210> 2
<211> 41
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 2
tcaaggcgaa tacttcatat ggcgcggctg atcggccgac g 41
<210> 3
<211> 30
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 3
gtgcgggccc ccgccgaaag gcccacgcgc 30
<210> 4
<211> 30
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 4
ctttcggcgg gggcccgcac cccagaggca 30
<210> 5
<211> 41
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 5
gacctgcagg catgcaagct ttctcctcgt ccgacgtcgt c 41
<210> 6
<211> 21
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 6
tcgtcatcgg tacggaagag g 21
<210> 7
<211> 21
<212> DNA
<213> 链霉菌(Streptomyces spectabilis CCTCC M2017417 )
<400> 7
gcggagttct ggttcgagat g 21

Claims (8)

1.一种Hangtaimycin生物合成基因簇，其特征在于：该生物合成基因簇的核苷酸序列如SEQ ID NO:1中第1-91594位所示。
2.根据权利要求1所述的Hangtaimycin生物合成基因簇，其特征在于：该生物合成基因簇的核苷酸序列如SEQ ID NO.1的第1-91594位的碱基序列所示，包含21个基因，具体为：
(1)负责hangtaimycin碳骨架合成及修饰的18个基因：
1)1号基因：htmA1位于基因簇核苷酸序列第10986-25451个碱基处，长度为14466个碱基对，编码聚酮合酶，4821个氨基酸；
2)2号基因：htmA2位于基因簇核苷酸序列第25448-47611个碱基处，长度为22164个碱基对，编码杂合的聚酮合酶与非核糖体肽合成酶，7387个氨基酸；
3)3号基因：htmA3位于基因簇核苷酸序列第47611-61857个碱基处，长度为14247个碱基对，编码聚酮合酶，4748个氨基酸；
4)4号基因：htmA4位于基因簇核苷酸序列第1-822个碱基处，长度为822个碱基对，编码游离的酮基还原酶，273个氨基酸；
5)5号基因：htmA5位于基因簇核苷酸序列第9823-10578个碱基处，长度为756个碱基对，编码II型硫酯酶，251个氨基酸；
6)6号基因：htmA6位于基因簇核苷酸序列第79115-80338个碱基处，长度为1221个碱基对，编码游离的失活酮基合成酶，负责脱羧，407个氨基酸；
7)7号基因：htmA7位于基因簇核苷酸序列第83995-85938个碱基处，长度为1944个碱基对，编码游离的酰基转移酶，负责延伸单元的转移，647个氨基酸；
8)8号基因：htmA8位于基因簇核苷酸序列第78787-79113个碱基处，长度为327个碱基对，编码游离的酰基载体蛋白，108个氨基酸；
9)9号基因：htmB1位于基因簇核苷酸序列第61854-69500个碱基处，长度为7647个碱基对，编码非核糖体肽合成酶，2548个氨基酸；
10)10号基因：htmB2位于基因簇核苷酸序列第69515-78790个碱基处，长度为9276个碱基对，编码非核糖体肽合成酶，3091个氨基酸；
11)11号基因：htmB3位于基因簇核苷酸序列第2214-3872个碱基处，长度为1659个碱基对，编码游离的氨酰转移酶，552个氨基酸；
12)12号基因：htmH位于基因簇核苷酸序列第81630-83990个碱基处，长度为2361个碱基对，编码脱水酶，786个氨基酸；
13)13号基因：htmI1位于基因簇核苷酸序列第934-2217个碱基处，长度为1284个碱基对，编码异构化酶，427个氨基酸；
14)14号基因：htmI2位于基因簇核苷酸序列第3932-4564个碱基处，长度为633个碱基对，编码异构化酶，210个氨基酸；
15)15号基因：htmO位于基因簇核苷酸序列第8335-9717个碱基处，长度为1383个碱基对，编码氨基合酶，460个氨基酸；
16)16号基因：htmP位于基因簇核苷酸序列第86021-87256个碱基处，长度为1236个碱基对，编码细胞色素P450氧化酶，411个氨基酸；
17)17号基因：htmS位于基因簇核苷酸序列第80359-81642个碱基处，长度为1284个碱基对，编码羟甲基戊二酸单酰辅酶A合成酶，427个氨基酸；
18)18号基因：htmT位于基因簇核苷酸序列第6346-7692个碱基处，长度为1257个碱基对，编码糖基转移酶，418个氨基酸；
(2)负责调控和转运的3个基因：
19)19号基因：htmR1位于基因簇核苷酸序列第7768-8274个碱基处，长度为507个碱基对，编码转录调控因子，168个氨基酸；
20)20号基因：htmR2位于基因簇核苷酸序列第88943-89740个碱基处，长度为798个碱基对，编码LysR家族转录调控因子，265个氨基酸；
21)21号基因：htmK位于基因簇核苷酸序列第89765-91594个碱基处，长度为1830个碱基对，编码Ser/Thr蛋白激酶，609个氨基酸。
3.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸序列可利用聚合酶链式反应PCR的方法或包含所述SEQ ID NO.1所示序列的第1-91594位的DNA作为探针，以Southern杂交方法从其它生物体中得到与hangtaimycin生物合基因簇相似的基因。
4.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述核苷酸列序列可用于通过合适的异源宿主表达，获得更高产量hangtaimycin；所述异源宿主包括放线菌、假单孢菌、大肠杆菌、芽孢杆菌、酵母或植物中任一种。
5.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于特定蛋白的表达及其抗体的制备。
6.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：利用所述核苷酸列序列转换的氨基酸序列用于提高特定蛋白的活性、优化蛋白的动力学特征。
7.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：所述生物合成基因簇通过遗传改造产生可用于医药、工业或农业的hangtaimycin。
8.一种如权利要求1或2所述的Hangtaimycin生物合成基因簇的应用，其特征在于：该生物合成基因簇的基因及其蛋白信息用于发现同类化合物、基因或蛋白。
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