DE69933874D1 - Topische zusammensetzung enthaltend ein opioid-analgetikum und einen nmda-antagonisten - Google Patents

Topische zusammensetzung enthaltend ein opioid-analgetikum und einen nmda-antagonisten

Info

Publication number
DE69933874D1
DE69933874D1 DE69933874T DE69933874T DE69933874D1 DE 69933874 D1 DE69933874 D1 DE 69933874D1 DE 69933874 T DE69933874 T DE 69933874T DE 69933874 T DE69933874 T DE 69933874T DE 69933874 D1 DE69933874 D1 DE 69933874D1
Authority
DE
Germany
Prior art keywords
morphine
topical
tolerance
nmda
peripheral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69933874T
Other languages
English (en)
Other versions
DE69933874T2 (de
Inventor
Yuri Kolesnikov
W Pasternak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sloan Kettering Institute for Cancer Research
Original Assignee
Sloan Kettering Institute for Cancer Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Institute for Cancer Research filed Critical Sloan Kettering Institute for Cancer Research
Publication of DE69933874D1 publication Critical patent/DE69933874D1/de
Application granted granted Critical
Publication of DE69933874T2 publication Critical patent/DE69933874T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69933874T 1998-07-16 1999-07-15 Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist Expired - Fee Related DE69933874T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9298298P 1998-07-16 1998-07-16
US92982P 1998-07-16
PCT/US1999/016049 WO2000003716A1 (en) 1998-07-16 1999-07-15 Topical compositions comprising an opioid analgesic and an nmda antagonist

Publications (2)

Publication Number Publication Date
DE69933874D1 true DE69933874D1 (de) 2006-12-14
DE69933874T2 DE69933874T2 (de) 2007-10-04

Family

ID=22236108

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69933874T Expired - Fee Related DE69933874T2 (de) 1998-07-16 1999-07-15 Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist

Country Status (15)

Country Link
US (1) US7700122B1 (de)
EP (1) EP1102589B1 (de)
JP (2) JP2002520363A (de)
KR (1) KR100762018B1 (de)
CN (1) CN1309562A (de)
AT (1) ATE344035T1 (de)
AU (1) AU758448B2 (de)
BR (1) BR9912827A (de)
CA (1) CA2336902C (de)
DE (1) DE69933874T2 (de)
DK (1) DK1102589T3 (de)
ES (1) ES2198196B2 (de)
IL (2) IL140834A0 (de)
PT (1) PT1102589E (de)
WO (1) WO2000003716A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69933874T2 (de) 1998-07-16 2007-10-04 Memorial Sloan-Kettering Institute For Cancer Research Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist
IL145552A0 (en) 1999-03-23 2002-06-30 Univ James Cook Organ arrest, protection and preservation
US6455066B1 (en) * 2000-03-10 2002-09-24 Epicept Corporation Intradermal-penetration agents for topical local anesthetic administration
IL152473A0 (en) * 2000-04-28 2003-05-29 Sloan Kettering Inst Cancer Topical anesthetic/opioid formulations and uses thereof
DE10025946A1 (de) * 2000-05-26 2001-11-29 Gruenenthal Gmbh Wirkstoffkombination
US20020013331A1 (en) 2000-06-26 2002-01-31 Williams Robert O. Methods and compositions for treating pain of the mucous membrane
US7820688B2 (en) 2001-04-27 2010-10-26 Memorial Sloan-Kettering Cancer Center Topical anesthetic/opioid formulations and uses thereof
DE60143671D1 (de) 2001-06-07 2011-01-27 Sang Christine Behandlung von neuropathischen schmerzen mittels eines n-methyl-d-aspartate (nmda)-rezeptor-antagonists
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
EP1545461A4 (de) * 2002-09-09 2011-06-22 Endo Pharmaceuticals Inc Analgetische zusammensetzung mit kombinierter sofortiger freisetzung und verlängerter freisetzung
WO2004056180A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery (1)
DE10340428B4 (de) * 2003-09-02 2015-02-12 Acino Ag Opioides Analgetikum enthaltende transdermale Formulierung
WO2006024018A2 (en) * 2004-08-24 2006-03-02 Neuromolecular Pharmaceuticals, Inc. Compositions for treating nociceptive pain
AU2006345361B2 (en) 2006-05-29 2014-04-10 Hibernation Therapeutics, A Kf Llc Improved tissue maintenance
CN101516185A (zh) 2006-07-25 2009-08-26 低温药理有限公司 创伤治疗
WO2008106724A1 (en) 2007-03-02 2008-09-12 Hibernation Therapeutics Limited Transplants
CN101317844B (zh) * 2007-06-08 2010-11-17 章劲夫 化合物(+)-5-甲基-10，11-二氢-5H-二苯并〔a，d〕环庚烯-5，10-亚胺在制备避孕药物中的应用
TWI380992B (zh) 2010-03-11 2013-01-01 Univ Ishou 一種抑制ｎｍｄａ受體ｎｒ１之小段干擾ｒｎａ、該小段干擾ｒｎａ用以抑制皮下組織ｎｍｄａ受體ｎｒ１之方法、該小段干擾ｒｎａ之用途以及一種減緩皮膚炎症性疼痛之藥物化合物
US8846765B2 (en) 2010-06-15 2014-09-30 Gruenenthal Gmbh Pharmaceutical combination
DE102010024105A1 (de) 2010-06-17 2011-12-22 Grünenthal GmbH Transdermale Verabreichung von Memantin
TWI417109B (zh) 2010-12-30 2013-12-01 Univ Ishou 一種用以抑制ｎｍｄａ受體ｎｒ１之短夾ｒｎａ、一種以短夾rna製備用以抑制ｎｍｄａ受體ｎｒ１之試劑之用途以及一種減緩皮膚炎症性疼痛之藥物
FR2998892B1 (fr) 2012-12-04 2015-01-02 Pf Medicament Derives d'aminocyclobutane, leur procede de preparation et leur utilisation a titre de medicaments
WO2015006827A1 (en) 2013-07-17 2015-01-22 Hts Therapeutics Pty Ltd A method for inducing whole body arrest
CN107028968B (zh) * 2016-02-03 2020-12-04 江苏恒瑞医药股份有限公司 一种含有葡萄糖醛酸吗啡或其可药用盐的药物组合物
CN114642744B (zh) * 2022-02-09 2023-05-23 南京医科大学 一种筛选缓解吗啡耐受药物的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5322683A (en) * 1989-05-01 1994-06-21 Leonard Mackles Anhydrous aerosol foam
JP2669951B2 (ja) * 1991-03-28 1997-10-29 雍憲 森本 麻薬性鎮痛剤を含有する経皮吸収組成物
JPH0733681A (ja) * 1993-05-18 1995-02-03 Sekisui Chem Co Ltd 経皮吸収貼付剤
US5635204A (en) * 1994-03-04 1997-06-03 Montefiore Medical Center Method for transdermal induction of anesthesia, analgesia or sedation
US5589480A (en) * 1994-08-17 1996-12-31 Elkhoury; George F. Topical application of opioid analgesic drugs such as morphine
JPH10513471A (ja) * 1995-02-10 1998-12-22 メドトロニック、インコーポレイテッド 鎮痛薬投与のための方法と装置
US5840731A (en) * 1995-08-02 1998-11-24 Virginia Commonwealth University Pain-alleviating drug composition and method for alleviating pain
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6197830B1 (en) * 1995-09-22 2001-03-06 Bruce M. Frome Method for achieving relief from sympathetically mediated pain
AUPN605795A0 (en) * 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
JPH09143061A (ja) * 1995-11-20 1997-06-03 Showa Denko Kk 鎮痛剤用経皮吸収製剤
US5891885A (en) * 1996-10-09 1999-04-06 Algos Pharmaceutical Corporation Method for treating migraine
WO1998016197A1 (en) * 1996-10-15 1998-04-23 Needham Charles W Surgical method and composition therefor
EP0946157B1 (de) 1996-12-16 2002-03-13 Alcon Laboratories, Inc. Topische verwendung von kappa-opioidrezeptoragonisten zur behandlung von augenschmerz
US6008258A (en) 1997-01-22 1999-12-28 Cornell Research Foundation, Inc. d-methadone, a nonopioid analegesic
DE69933874T2 (de) 1998-07-16 2007-10-04 Memorial Sloan-Kettering Institute For Cancer Research Topische zusammensetzung enthaltend ein opioid-analgetika und einen nmda-antagonist
JP2000169378A (ja) 1998-12-10 2000-06-20 Taisho Pharmaceut Co Ltd 咽頭疾患用組成物
IL152473A0 (en) * 2000-04-28 2003-05-29 Sloan Kettering Inst Cancer Topical anesthetic/opioid formulations and uses thereof

Also Published As

Publication number Publication date
IL140834A0 (en) 2002-02-10
JP2002520363A (ja) 2002-07-09
CN1309562A (zh) 2001-08-22
JP2007246546A (ja) 2007-09-27
CA2336902A1 (en) 2000-01-27
BR9912827A (pt) 2001-05-02
EP1102589A1 (de) 2001-05-30
AU758448B2 (en) 2003-03-20
KR100762018B1 (ko) 2007-10-04
ES2198196A1 (es) 2004-01-16
PT1102589E (pt) 2006-12-29
DK1102589T3 (da) 2006-12-04
DE69933874T2 (de) 2007-10-04
IL140834A (en) 2009-02-11
US7700122B1 (en) 2010-04-20
EP1102589B1 (de) 2006-11-02
WO2000003716A1 (en) 2000-01-27
ATE344035T1 (de) 2006-11-15
KR20010070969A (ko) 2001-07-28
CA2336902C (en) 2009-04-21
AU4998799A (en) 2000-02-07
ES2198196B2 (es) 2006-04-01

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee