DE69932425D1 - Attenuierte salmonella mutanten, welche das vi-antigen konstant exprimieren - Google Patents
Attenuierte salmonella mutanten, welche das vi-antigen konstant exprimierenInfo
- Publication number
- DE69932425D1 DE69932425D1 DE69932425T DE69932425T DE69932425D1 DE 69932425 D1 DE69932425 D1 DE 69932425D1 DE 69932425 T DE69932425 T DE 69932425T DE 69932425 T DE69932425 T DE 69932425T DE 69932425 D1 DE69932425 D1 DE 69932425D1
- Authority
- DE
- Germany
- Prior art keywords
- attenuated salmonella
- salmonella mutants
- antigen
- mutants expressing
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000607142 Salmonella Species 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 230000002238 attenuated effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 208000037386 Typhoid Diseases 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 229940023832 live vector-vaccine Drugs 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 201000008297 typhoid fever Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/879—Salmonella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/076,761 US6190669B1 (en) | 1998-05-13 | 1998-05-13 | Attenuated mutants of salmonella which constitutively express the Vi antigen |
US76761 | 1998-05-13 | ||
PCT/US1999/006554 WO1999058146A1 (en) | 1998-05-13 | 1999-04-30 | ATTENUATED MUTANTS OF SALMONELLA WHICH CONSTITUTIVELY EXPRESS THE Vi ANTIGEN |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69932425D1 true DE69932425D1 (de) | 2006-08-31 |
DE69932425T2 DE69932425T2 (de) | 2007-03-08 |
Family
ID=22134022
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69932425T Expired - Lifetime DE69932425T2 (de) | 1998-05-13 | 1999-04-30 | Attenuierte salmonella mutanten, welche das vi-antigen konstant exprimieren |
Country Status (16)
Country | Link |
---|---|
US (1) | US6190669B1 (de) |
EP (1) | EP1076566B1 (de) |
JP (1) | JP4363782B2 (de) |
AT (1) | ATE333285T1 (de) |
AU (1) | AU754795B2 (de) |
CA (1) | CA2328056C (de) |
DE (1) | DE69932425T2 (de) |
DK (1) | DK1076566T3 (de) |
ES (1) | ES2268864T3 (de) |
HU (1) | HUP0101747A3 (de) |
MX (1) | MXPA00011075A (de) |
NO (1) | NO20005672L (de) |
NZ (1) | NZ508110A (de) |
PL (1) | PL192378B1 (de) |
WO (1) | WO1999058146A1 (de) |
ZA (1) | ZA200006381B (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3633933B2 (ja) * | 1992-07-31 | 2005-03-30 | アカンビス、リサーチ、リミテッド | 弱毒化細菌における組換え融合タンパク質の発現 |
GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
US6797275B1 (en) * | 1998-12-04 | 2004-09-28 | The United States Of America As Represented By The Department Of Health And Human Services | Method of immunizing humans against Salmonella typhi using a Vi-rEPA conjugate vaccine |
DE69930147T2 (de) * | 1998-12-04 | 2007-01-11 | University Of Manitoba, Winnipeg | Zwei-schritte-verfahren zur impfung gegen chlamydia |
US7026155B2 (en) * | 1999-02-02 | 2006-04-11 | Regents Of The University Of California | Method of reducing bacterial proliferation |
DE60011560T2 (de) * | 1999-12-28 | 2005-08-18 | Akzo Nobel N.V. | Salmonella Impfstoff, der keinen Antikörper gegen Flagellin oder gegen Flagella induziert |
DE60125528T2 (de) * | 2000-04-20 | 2007-10-11 | University Of Maryland, Baltimore | Isolierung und charakterisierung des csa-operons (etec-cs4 pili) und verfahren zu dessen anwendung |
US7780961B2 (en) * | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
US7541043B2 (en) | 2002-01-16 | 2009-06-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vaccine for protection against Shigella sonnei disease |
JP2005529622A (ja) * | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
WO2004046346A2 (en) * | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain |
JP2009516503A (ja) * | 2005-10-28 | 2009-04-23 | ユニバーシティ オブ メリーランド, ボルチモア | 弱毒化s・パラチフスa菌株およびその使用 |
US8137930B2 (en) | 2005-10-28 | 2012-03-20 | University Of Maryland, Baltimore | Attenuated Salmonella enterica serovar paratyphi A and uses thereof |
WO2007062371A2 (en) * | 2005-11-23 | 2007-05-31 | University Of Maryland, Baltimore | Live vector vaccine and uses thereof |
ES2405552T3 (es) | 2005-11-29 | 2013-05-31 | Actogenix N.V. | Inducción de tolerancia mucosa a antiantígenos de células beta de islotes pancreáticos |
JP2009529895A (ja) * | 2006-03-20 | 2009-08-27 | ヴリジェ ユニヴェルシテ ブリュッセル | 弱毒化サルモネラ生ワクチン |
JP2009531029A (ja) * | 2006-03-20 | 2009-09-03 | ヴリジェ ユニヴェルシテ ブリュッセル | 弱毒化サルモネラ生ワクチン |
EP2066339B1 (de) | 2006-09-18 | 2014-08-13 | The Board Of Trustees Of The University Of Arkansas | Zusammensetzungen und verfahren zur verstärkung von immunreaktionen |
BRPI0807857A2 (pt) | 2007-01-25 | 2014-05-27 | Actogenix Nv | Tratamento de doença imune por meio de distribuição através da mucosa de antígenos. |
US20110020399A1 (en) * | 2007-04-16 | 2011-01-27 | University Of Maryland, Baltimore | Vaccines and Immunomodulatory Therapies for Tularemia |
AU2008318615A1 (en) * | 2007-10-30 | 2009-05-07 | Texas A&M University System | Compositions and methods of enhancing immune responses to flagellated bacterium |
HUE047164T2 (hu) | 2007-11-01 | 2020-04-28 | Univ Arkansas | Kompozíciók és eljárások eimeria elleni immunválasz fokozására |
WO2010036226A1 (en) * | 2008-09-26 | 2010-04-01 | George Nelson | Process for treatment of rheumatoid arthritis, tremors/parkinson's disease and multiple sclerosis |
WO2010141143A2 (en) * | 2009-04-21 | 2010-12-09 | Vivocure, Inc. | Engineered avirulent bacteria strains and use in medical treatments |
CA2787661C (en) | 2010-01-21 | 2021-10-12 | The Board Of Trustees Of The University Of Arkansas | Vaccine vectors and methods of enhancing immune responses |
EP3556397A1 (de) | 2010-06-09 | 2019-10-23 | The Board of Trustees of the University of Arkansas | Impfstoff und verfahren zur linderung einer campylobacter-infektion |
WO2013126622A1 (en) * | 2012-02-24 | 2013-08-29 | President And Fellows Of Harvard College | Methods for displaying polypeptides and uses thereof |
PL2956165T3 (pl) | 2013-02-14 | 2020-04-30 | The Board Of Trustees Of The University Of Arkansas | Kompozycje i sposoby wzmacniania odpowiedzi immunologicznych na Eimeria lub ograniczania infekcji Eimeria |
EA033538B1 (ru) | 2013-03-15 | 2019-10-31 | Univ Arkansas | Композиции и способы усиления иммунного ответа на кишечные патогены |
US10682398B2 (en) | 2016-05-03 | 2020-06-16 | The Texas A&M University System | Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same |
AU2022343176A1 (en) * | 2021-09-10 | 2024-04-11 | Regents Of The University Of Minnesota | Salmonella engineered for nontoxic colonization of tumors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5077044A (en) | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
US5783196A (en) | 1996-04-09 | 1998-07-21 | University Of Maryland At Baltimore | Gua mutants of shigella spp. and vaccines containing the same |
-
1998
- 1998-05-13 US US09/076,761 patent/US6190669B1/en not_active Expired - Lifetime
-
1999
- 1999-04-30 AT AT99919755T patent/ATE333285T1/de not_active IP Right Cessation
- 1999-04-30 JP JP2000547997A patent/JP4363782B2/ja not_active Expired - Fee Related
- 1999-04-30 NZ NZ508110A patent/NZ508110A/xx unknown
- 1999-04-30 PL PL344593A patent/PL192378B1/pl unknown
- 1999-04-30 ES ES99919755T patent/ES2268864T3/es not_active Expired - Lifetime
- 1999-04-30 DK DK99919755T patent/DK1076566T3/da active
- 1999-04-30 HU HU0101747A patent/HUP0101747A3/hu unknown
- 1999-04-30 WO PCT/US1999/006554 patent/WO1999058146A1/en active IP Right Grant
- 1999-04-30 EP EP99919755A patent/EP1076566B1/de not_active Expired - Lifetime
- 1999-04-30 DE DE69932425T patent/DE69932425T2/de not_active Expired - Lifetime
- 1999-04-30 AU AU37405/99A patent/AU754795B2/en not_active Expired
- 1999-04-30 MX MXPA00011075A patent/MXPA00011075A/es not_active IP Right Cessation
- 1999-04-30 CA CA2328056A patent/CA2328056C/en not_active Expired - Lifetime
-
2000
- 2000-11-07 ZA ZA200006381A patent/ZA200006381B/en unknown
- 2000-11-10 NO NO20005672A patent/NO20005672L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ZA200006381B (en) | 2002-02-07 |
JP2002514398A (ja) | 2002-05-21 |
PL344593A1 (en) | 2001-11-05 |
DK1076566T3 (da) | 2006-11-13 |
CA2328056C (en) | 2010-07-06 |
EP1076566B1 (de) | 2006-07-19 |
JP4363782B2 (ja) | 2009-11-11 |
AU3740599A (en) | 1999-11-29 |
WO1999058146A1 (en) | 1999-11-18 |
PL192378B1 (pl) | 2006-10-31 |
ATE333285T1 (de) | 2006-08-15 |
CA2328056A1 (en) | 1999-11-18 |
AU754795B2 (en) | 2002-11-28 |
NO20005672L (no) | 2001-01-15 |
NZ508110A (en) | 2002-10-25 |
US6190669B1 (en) | 2001-02-20 |
ES2268864T3 (es) | 2007-03-16 |
HUP0101747A2 (hu) | 2001-09-28 |
NO20005672D0 (no) | 2000-11-10 |
EP1076566A4 (de) | 2005-01-05 |
MXPA00011075A (es) | 2002-04-24 |
HUP0101747A3 (en) | 2002-03-28 |
DE69932425T2 (de) | 2007-03-08 |
EP1076566A1 (de) | 2001-02-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69932425D1 (de) | Attenuierte salmonella mutanten, welche das vi-antigen konstant exprimieren | |
DE69841437D1 (de) | Bakterielle impfstoffe, enthaltend auxotrophe attenuierte listerienstämme, welche heterologe antigene exprimieren | |
RU92004496A (ru) | Новые пиперазинил- и пиперидинилциклогексанолы | |
DK142391D0 (da) | Indretning til tilberedning, servering og opbevaring af f.eks. madvarer | |
BR9916132A (pt) | Composições e utilização das mesmas | |
FI920992A0 (fi) | Foerfarande foer framstaellning av i industriell skala av ett standardiserat koncentrat av human von willebrand-faktor, vilket har synnerligen hoeg renhet och aer laempligt foer terapeutisk anvaendning. | |
NL194881B (nl) | Tomografie detector temperatuurcompensatie. | |
IT8120701A0 (it) | Prodotto di stelo o simili di tabacco trinciato, e procedimento per ottenerlo. | |
IT9022356A0 (it) | Indumento refrigerante, in particolare del tipo giubbotto o simile. | |
FR2661182B1 (fr) | Compositions stabilisees de polymere halogene. | |
IT8821705A0 (it) | Acciao inossidabile duplex saldabile tenace. | |
ATE425758T1 (de) | Modifizierte polysaccharide mit veranderter biologischer erkennung | |
DK0929299T3 (da) | Substituerede 1,2,3,4-tetrahydro-2-dibenzofuranaminer og 2-aminocyclohepta-(b)benzofuraner | |
IT8123022A0 (it) | Frigorifero, congelatore o simile, elettrodomestico, in particolare perfezionato. | |
FR2682277B1 (fr) | Recipient isotherme. | |
DE3761149D1 (de) | Wolframkarbid-kobalt-verbundwerkstoff mit verbesserten reibungseigenschaften. | |
TR199600082A2 (tr) | Gelistirilmis üstüne yazma özelliklerine sahip, ozona zarar vermeyen düzeltme yapma sivisi. | |
DK0504567T3 (da) | Køleapparat, især husholdningskøleskab eller lignende | |
AR244752A1 (es) | Azocolorantes, procedimiento para su preparacion y su empleo. | |
IT8224423A0 (it) | Apparecchio congelatore, specialmente armadio congelatore per uso domestico o similare. | |
IT8722938A0 (it) | Carrello scorrevole per vetrine, esimili. | |
MX9102492A (es) | Procedimiento para la determinacion del origen de bebidas espirituosas. | |
FI912587A0 (fi) | Foerfarande foer isolering och uttryck av en streptokinas kodande gen, pao detta saett framstaelld nukleotidsekvens, rekombinations-dna och transformerade micro- organismer. | |
IT8420563A0 (it) | Apparecchio congelatore, specialmente apparecchio congelatore per uso domestico o similare. | |
ES1018128Y (es) | Asador natural, con soporte de manipulacion. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |