DE69932183D1 - ANWENDUNG VON ZIELGERICHTETEM RADIUM 223 FüR PALLIATIVE UND THERAPEUTISCHE BEHANDLUNG VON KNOCHENKREBS - Google Patents

ANWENDUNG VON ZIELGERICHTETEM RADIUM 223 FüR PALLIATIVE UND THERAPEUTISCHE BEHANDLUNG VON KNOCHENKREBS

Info

Publication number
DE69932183D1
DE69932183D1 DE69932183T DE69932183T DE69932183D1 DE 69932183 D1 DE69932183 D1 DE 69932183D1 DE 69932183 T DE69932183 T DE 69932183T DE 69932183 T DE69932183 T DE 69932183T DE 69932183 D1 DE69932183 D1 DE 69932183D1
Authority
DE
Germany
Prior art keywords
radium
palliative
targeted
application
therapeutic treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69932183T
Other languages
English (en)
Other versions
DE69932183T2 (de
Inventor
H Larsen
Gjermund Henriksen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AS
Original Assignee
Algeta ASA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algeta ASA filed Critical Algeta ASA
Application granted granted Critical
Publication of DE69932183D1 publication Critical patent/DE69932183D1/de
Publication of DE69932183T2 publication Critical patent/DE69932183T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Radiation-Therapy Devices (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Compounds Of Unknown Constitution (AREA)
DE69932183T 1999-01-04 1999-12-17 ANWENDUNG VON ZIELGERICHTETEM RADIUM 223 FüR PALLIATIVE UND THERAPEUTISCHE BEHANDLUNG VON KNOCHENKREBS Expired - Lifetime DE69932183T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO990001A NO310544B1 (no) 1999-01-04 1999-01-04 Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
NO990001 1999-01-04
PCT/NO1999/000392 WO2000040275A2 (en) 1999-01-04 1999-12-17 The preparation and use of radium-223 to target calcified tissues for pain palliation, bone cancer therapy, and bone surface conditioning

Publications (2)

Publication Number Publication Date
DE69932183D1 true DE69932183D1 (de) 2006-08-10
DE69932183T2 DE69932183T2 (de) 2007-05-16

Family

ID=19902803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69932183T Expired - Lifetime DE69932183T2 (de) 1999-01-04 1999-12-17 ANWENDUNG VON ZIELGERICHTETEM RADIUM 223 FüR PALLIATIVE UND THERAPEUTISCHE BEHANDLUNG VON KNOCHENKREBS

Country Status (25)

Country Link
US (2) US6635234B1 (de)
EP (1) EP1140212B1 (de)
JP (2) JP4649044B2 (de)
KR (1) KR100671387B1 (de)
CN (2) CN1767078B (de)
AT (1) ATE331534T1 (de)
AU (1) AU774991B2 (de)
BE (1) BE2014C028I2 (de)
BR (1) BR9916768A (de)
CA (1) CA2358498C (de)
CY (2) CY1105634T1 (de)
DE (1) DE69932183T2 (de)
DK (1) DK1140212T3 (de)
EA (1) EA003496B1 (de)
ES (1) ES2268888T3 (de)
HK (1) HK1090750A1 (de)
IL (1) IL144135A0 (de)
LU (1) LU92425I2 (de)
MX (1) MXPA01006823A (de)
NO (2) NO310544B1 (de)
NZ (3) NZ513135A (de)
PT (1) PT1140212E (de)
TR (3) TR200201442T2 (de)
WO (1) WO2000040275A2 (de)
ZA (1) ZA200105431B (de)

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NO314537B1 (no) * 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
AUPQ923100A0 (en) * 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer
AU2002364051A1 (en) * 2002-01-24 2003-09-02 Children's Medical Center Corporation Anti-cancer combination and use thereof
GB0213261D0 (en) * 2002-06-10 2002-07-17 Anticancer Therapeutic Inv Sa Method
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
WO2004096293A2 (en) * 2003-04-30 2004-11-11 Ramot At Tel Aviv University Ltd. Method and device for radiotherapy
EP1735013B1 (de) * 2004-02-20 2012-02-08 Algeta ASA Alpha- und beta-emittierende hydroxyapatit-teilchen
DE102004022200B4 (de) * 2004-05-05 2006-07-20 Actinium Pharmaceuticals, Inc. Radium-Target sowie Verfahren zu seiner Herstellung
US7914766B1 (en) * 2004-06-03 2011-03-29 Ut-Battelle Llc Inorganic resins for clinical use of 213Bi generators
GB0423565D0 (en) * 2004-10-22 2004-11-24 Algeta As Formulation
DK2510952T3 (en) * 2005-07-26 2019-01-07 Alpha Tau Medical Ltd RADIOACTIVE SURFACE SOURCE AND PROCEDURE FOR PREPARING IT
US8709380B1 (en) * 2006-02-07 2014-04-29 Sirius Medicine, Llc Targeting agents for enhancing radiation therapy
DE102006008023B4 (de) * 2006-02-21 2008-05-29 Actinium Pharmaceuticals, Inc. Verfahren zum Reinigen von 225Ac aus bestrahlten 226Ra-Targets
ES2504522T3 (es) 2006-09-08 2014-10-08 Actinium Pharmaceuticals Inc. Método para la purificación de radio a partir de diferentes fuentes
EP2116539A1 (de) 2008-04-25 2009-11-11 Laboratorios Del. Dr. Esteve, S.A. 1-Aryl-3-Amino-alkoxy-pyrazole als Sigma-Liganden zur Verbesserung der analgetischen Wirkung von Opioiden und zur Schwächung der Abhängigkeit davon
EP2353598A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Anwendung in der Vorbeugung und/oder Behandlung von postoperativem Schmerz
EP2353591A1 (de) 2010-02-04 2011-08-10 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Verstärkung der analgesischen Wirkung von Opioden und Opiaten bei postoperativem Schmerz und zur Schwächung der Abhängigkeit davon
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
GB201007354D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
GB201007353D0 (en) * 2010-04-30 2010-06-16 Algeta Asa Method
EP2388005A1 (de) 2010-05-21 2011-11-23 Laboratorios Del. Dr. Esteve, S.A. Sigma-Liganden zur Vorbeugung und/oder Behandlung von Erbrechen infolge von Chemotherapie oder Strahlentherapie
EP2415471A1 (de) 2010-08-03 2012-02-08 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei opioidinduzierter Hyperalgesie
EP2524694A1 (de) 2011-05-19 2012-11-21 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Sigmaliganden bei Schmerz im Zusammenhang mit Typ-2-Diabetes
EP2934545A1 (de) 2012-12-19 2015-10-28 Bayer Pharma Aktiengesellschaft Kombination aus radium-223 zur behandlung von krebs
GB201314718D0 (en) * 2013-08-16 2013-10-02 Algeta As Quantification method
EP3077003A1 (de) 2013-12-03 2016-10-12 Bayer Pharma Aktiengesellschaft Kombination von pi3k-inhibitoren
CN105934256B (zh) 2013-12-03 2019-12-27 拜耳制药股份公司 Pi3k-抑制剂的组合产品
KR20160097366A (ko) 2013-12-17 2016-08-17 라보라토리오스 델 드라. 에스테브.에스.에이. 세로토닌-노르에피네프린 재흡수 억제제들(SNRIs) 및 시그마 리셉터 리간드들 조합
WO2016083739A1 (fr) 2014-11-26 2016-06-02 Rhodia Operations Composition de lanthane et d'actinium-227
GB201600153D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
GB201600154D0 (en) * 2016-01-05 2016-02-17 Bayer As Isotope preparation method
CZ2016821A3 (cs) * 2016-12-22 2018-07-04 České vysoké učení technické v Praze Kombinace pro radionuklidovou terapii pro použití jako léčivo
AR110995A1 (es) 2017-02-24 2019-05-22 Bayer Ag Combinación de inhibidores de quinasa atr con sal de radio-223
JP7232489B2 (ja) 2017-05-11 2023-03-03 アルファ タウ メディカル リミテッド 近接照射療法用装置のためのポリマー被覆
KR20200139722A (ko) 2018-04-02 2020-12-14 알파 타우 메디컬 리미티드 방사성 핵종의 제어된 방출
EP3563875A1 (de) * 2018-05-04 2019-11-06 Ceské vysoké ucení technické v Praze Radium für radionuklidtherapie, zusammen mit calciummetabolisme- beeinflüssender therapie
FR3086186B1 (fr) * 2018-09-26 2022-01-28 Orano Med Procede de production de plomb-212 a partir d'une solution aqueuse comprenant du thorium-228 et ses descendants
FR3088769B1 (fr) * 2018-11-15 2020-12-25 Orano Med Procede de preparation d'au moins un generateur a haute teneur en radium-228
US20220152228A1 (en) * 2019-03-01 2022-05-19 Washington University Compositions and methods for radiotherapy using chelated radiotherapeutic agents and non-target tissue blockade
RU2752845C1 (ru) * 2020-05-13 2021-08-11 Акционерное Общество "Наука И Инновации" Способ получения высокочистого радия-223
US11857803B2 (en) 2020-12-16 2024-01-02 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy with enhanced beta treatment
CN113066598B (zh) * 2021-03-25 2023-08-08 中国科学院近代物理研究所 一种从高能质子束辐照232Th靶引起的散裂反应中分离纯化223Ra的方法
US11964168B2 (en) 2021-06-10 2024-04-23 Alpha Tau Medical Ltd. Diffusing alpha-emitter radiation therapy for prostate cancer
WO2023159230A1 (en) 2022-02-21 2023-08-24 Bayer Healthcare Llc System, method and device for delivery of a therapeutic or diagnostic agent
WO2023159229A1 (en) 2022-02-21 2023-08-24 Bayer Healthcare Llc System, method and device for delivery of a therapeutic or diagnostic agent

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NO314537B1 (no) * 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
NO312708B1 (no) * 2000-02-21 2002-06-24 Anticancer Therapeutic Inv Sa Radioaktive liposomer til terapi
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
GB0213261D0 (en) * 2002-06-10 2002-07-17 Anticancer Therapeutic Inv Sa Method
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GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy

Also Published As

Publication number Publication date
JP5433490B2 (ja) 2014-03-05
US6635234B1 (en) 2003-10-21
NZ513135A (en) 2004-09-24
DK1140212T3 (da) 2006-10-09
NO2014010I2 (de) 2014-05-09
KR100671387B1 (ko) 2007-01-19
CN1335779A (zh) 2002-02-13
AU1700400A (en) 2000-07-24
WO2000040275A3 (en) 2001-06-21
EA200100642A1 (ru) 2002-02-28
NZ534618A (en) 2006-03-31
NO310544B1 (no) 2001-07-23
US20030206857A1 (en) 2003-11-06
JP4649044B2 (ja) 2011-03-09
CY2014020I2 (el) 2015-12-09
KR20010092772A (ko) 2001-10-26
EP1140212A2 (de) 2001-10-10
LU92425I2 (fr) 2014-06-10
NO990001L (no) 2000-07-05
CN1767078B (zh) 2012-01-11
CY2014020I1 (el) 2015-12-09
WO2000040275A2 (en) 2000-07-13
ES2268888T3 (es) 2007-03-16
NO2014010I1 (no) 2014-06-02
DE69932183T2 (de) 2007-05-16
PT1140212E (pt) 2006-11-30
CN1194764C (zh) 2005-03-30
MXPA01006823A (es) 2003-07-14
CA2358498C (en) 2008-09-16
EP1140212B1 (de) 2006-06-28
ATE331534T1 (de) 2006-07-15
JP2010168397A (ja) 2010-08-05
JP2002534399A (ja) 2002-10-15
TR200201440T2 (tr) 2002-08-21
BR9916768A (pt) 2001-12-04
CY1105634T1 (el) 2010-12-22
IL144135A0 (en) 2002-05-23
TR200201442T2 (tr) 2002-08-21
NZ545023A (en) 2007-08-31
CN1767078A (zh) 2006-05-03
AU774991B2 (en) 2004-07-15
ZA200105431B (en) 2002-07-02
NO990001D0 (no) 1999-01-04
EA003496B1 (ru) 2003-06-26
HK1090750A1 (en) 2006-12-29
TR200102707T2 (tr) 2002-03-21
CA2358498A1 (en) 2000-07-13
BE2014C028I2 (de) 2019-03-05

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