DE69927735T2 - Die Verwendung von Somatostatin-Derivaten und/oder von Phenylhydrazon-Derivaten - Google Patents

Die Verwendung von Somatostatin-Derivaten und/oder von Phenylhydrazon-Derivaten Download PDF

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Publication number
DE69927735T2
DE69927735T2 DE69927735T DE69927735T DE69927735T2 DE 69927735 T2 DE69927735 T2 DE 69927735T2 DE 69927735 T DE69927735 T DE 69927735T DE 69927735 T DE69927735 T DE 69927735T DE 69927735 T2 DE69927735 T2 DE 69927735T2
Authority
DE
Germany
Prior art keywords
group
phenylhydrazone
phenylamino
neurogenic
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69927735T
Other languages
German (de)
English (en)
Other versions
DE69927735D1 (de
Inventor
Dr. Gyorgy Keri
Dr. Janos Szolcsanyi
Dr. Erika Pinter
Dr. Zsuzsanna Helyes
Dr. Judit Erchegyi
Dr. Aniko Horvath
Judit Horvath
Dr. Istvan Teplan
Dr. Laszlo Orfi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biostatin Gyogyszerkutato-Fejleszto Kft
Original Assignee
Biostatin Gyogyszerkutato-Fejleszto Kft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biostatin Gyogyszerkutato-Fejleszto Kft filed Critical Biostatin Gyogyszerkutato-Fejleszto Kft
Publication of DE69927735D1 publication Critical patent/DE69927735D1/de
Application granted granted Critical
Publication of DE69927735T2 publication Critical patent/DE69927735T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/655Somatostatins
    • C07K14/6555Somatostatins at least 1 amino acid in D-form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/72Hydrazones
    • C07C251/86Hydrazones having doubly-bound carbon atoms of hydrazone groups bound to carbon atoms of six-membered aromatic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69927735T 1998-04-27 1999-04-23 Die Verwendung von Somatostatin-Derivaten und/oder von Phenylhydrazon-Derivaten Expired - Fee Related DE69927735T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9800970A HU226567B1 (en) 1998-04-27 1998-04-27 Use of phenylhydrazon derivates for the preparation of medicaments for the inhibition of neurogenic and non-neurogenic inflammations and for the alleviation of pain
HU9800970 1998-04-27

Publications (2)

Publication Number Publication Date
DE69927735D1 DE69927735D1 (de) 2006-03-02
DE69927735T2 true DE69927735T2 (de) 2006-07-20

Family

ID=89996480

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927735T Expired - Fee Related DE69927735T2 (de) 1998-04-27 1999-04-23 Die Verwendung von Somatostatin-Derivaten und/oder von Phenylhydrazon-Derivaten

Country Status (10)

Country Link
US (1) US6689813B2 (enExample)
EP (1) EP0952159B1 (enExample)
JP (1) JP2000001439A (enExample)
KR (1) KR19990083438A (enExample)
AT (1) ATE307145T1 (enExample)
CA (1) CA2269995A1 (enExample)
DE (1) DE69927735T2 (enExample)
DK (1) DK0952159T3 (enExample)
ES (1) ES2251803T3 (enExample)
HU (1) HU226567B1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2353072A1 (en) * 1998-12-14 2000-06-22 Palatin Technologies, Inc. Metallopeptide combinatorial libraries and applications
US7049398B1 (en) * 1999-08-12 2006-05-23 Palatin Technologies, Inc. Melanocortin metallopeptide constructs, combinatorial libraries and applications
AU1623801A (en) * 1999-11-19 2001-05-30 Palatin Technologies, Inc. Opioid metallopeptide compositions and methods
US7385025B2 (en) * 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
AU2002238106A1 (en) * 2001-02-13 2002-08-28 Palatin Technologies, Inc. Melanocortin metallopeptides for treatment of sexual dysfunction
US20040106548A1 (en) * 2001-09-07 2004-06-03 Schmidt Michelle A Conformationally constrained labeled peptides for imaging and therapy
CA2561560A1 (en) 2004-03-30 2005-10-13 The Regents Of The University Of California Hydrazide-containing cftr inhibitor compounds and uses thereof
WO2008079897A2 (en) 2006-12-22 2008-07-03 The Regents Of The University Of California Macromolecular conjugates of cystic fibrosis transmembrane conductance regulator protein inhibitors and uses thereof
BRPI0809498A2 (pt) 2007-04-02 2014-09-23 Inst Oneworld Health Compostos inibidores de cftr e seus usos
US8207205B2 (en) 2008-04-21 2012-06-26 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
WO2009131951A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
DE202012002243U1 (de) 2012-03-02 2012-04-27 Wilhelm Bilstein Gmbh & Co. Kg Messerhalter für Kreismesser

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894083A (en) * 1972-09-21 1975-07-08 Sandoz Ltd Amides
DE3409415A1 (de) * 1984-03-14 1985-09-26 Medice Chem.-Pharm. Fabrik Pütter GmbH & Co KG, 5860 Iserlohn Arzneimittel, insbesondere gegen entzuendungen
HU207104B (en) * 1991-01-25 1993-03-01 Biosignal Kutato Fejlesztoe Kf Process for producing new somatostatin analogs inhibiting tumour growth and pharmaceutical compositions comprising such compounds
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
US5888765A (en) * 1995-06-23 1999-03-30 President And Fellows Of Harvard College Endothelial-cell specific promoter

Also Published As

Publication number Publication date
HUP9800970A3 (en) 2000-04-28
US20010009899A1 (en) 2001-07-26
KR19990083438A (ko) 1999-11-25
DE69927735D1 (de) 2006-03-02
JP2000001439A (ja) 2000-01-07
EP0952159A2 (en) 1999-10-27
US6689813B2 (en) 2004-02-10
EP0952159A3 (en) 2000-08-09
ATE307145T1 (de) 2005-11-15
CA2269995A1 (en) 1999-10-27
HU9800970D0 (en) 1998-06-29
DK0952159T3 (da) 2006-03-06
HU226567B1 (en) 2009-04-28
HUP9800970A2 (hu) 2000-02-28
ES2251803T3 (es) 2006-05-01
EP0952159B1 (en) 2005-10-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: VOSSIUS & PARTNER, 81675 MUENCHEN

8339 Ceased/non-payment of the annual fee