DE69927498T2 - Pektine aus aloe - Google Patents
Pektine aus aloe Download PDFInfo
- Publication number
- DE69927498T2 DE69927498T2 DE69927498T DE69927498T DE69927498T2 DE 69927498 T2 DE69927498 T2 DE 69927498T2 DE 69927498 T DE69927498 T DE 69927498T DE 69927498 T DE69927498 T DE 69927498T DE 69927498 T2 DE69927498 T2 DE 69927498T2
- Authority
- DE
- Germany
- Prior art keywords
- pectic substance
- extraction
- gel
- aloe
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000011399 aloe vera Nutrition 0.000 title claims description 149
- 241001116389 Aloe Species 0.000 title claims description 118
- AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 title claims description 64
- 229920001277 pectin Polymers 0.000 claims description 367
- 239000001814 pectin Substances 0.000 claims description 362
- 235000010987 pectin Nutrition 0.000 claims description 360
- 238000000605 extraction Methods 0.000 claims description 141
- 239000000243 solution Substances 0.000 claims description 68
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 56
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 50
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 claims description 44
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 36
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 34
- 244000144927 Aloe barbadensis Species 0.000 claims description 32
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 21
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- 239000011780 sodium chloride Substances 0.000 description 51
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- 241000220225 Malus Species 0.000 description 18
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- 239000005017 polysaccharide Substances 0.000 description 15
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
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- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 9
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 9
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- 235000021536 Sugar beet Nutrition 0.000 description 9
- 238000006640 acetylation reaction Methods 0.000 description 9
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- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 description 8
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- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0003—General processes for their isolation or fractionation, e.g. purification or extraction from biomass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0045—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Galacturonans, e.g. methyl ester of (alpha-1,4)-linked D-galacturonic acid units, i.e. pectin, or hydrolysis product of methyl ester of alpha-1,4-linked D-galacturonic acid units, i.e. pectinic acid; Derivatives thereof
- C08B37/0048—Processes of extraction from organic materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C08J3/075—Macromolecular gels
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/06—Pectin; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
- C08J2305/06—Pectin; Derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Inorganic Chemistry (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/078,204 US5929051A (en) | 1998-05-13 | 1998-05-13 | Aloe pectins |
| PCT/US1999/010335 WO1999058575A1 (en) | 1998-05-13 | 1999-05-12 | Aloe pectins |
| US78204 | 2008-07-03 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69927498D1 DE69927498D1 (de) | 2006-02-09 |
| DE69927498T2 true DE69927498T2 (de) | 2006-07-13 |
Family
ID=22142598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69927498T Expired - Lifetime DE69927498T2 (de) | 1998-05-13 | 1999-05-12 | Pektine aus aloe |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5929051A (enExample) |
| EP (2) | EP1086141B1 (enExample) |
| JP (1) | JP2002514663A (enExample) |
| KR (1) | KR100587423B1 (enExample) |
| AU (1) | AU3898999A (enExample) |
| CA (1) | CA2331744C (enExample) |
| DE (1) | DE69927498T2 (enExample) |
| WO (1) | WO1999058575A1 (enExample) |
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|---|---|---|---|---|
| US7022683B1 (en) * | 1998-05-13 | 2006-04-04 | Carrington Laboratories, Inc. | Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation |
| US6313103B1 (en) * | 1998-05-13 | 2001-11-06 | Carrington Laboratories, Inc. | Pectic substance as a growth factor stabilizer |
| US6916495B2 (en) * | 1999-02-24 | 2005-07-12 | Allan Taylor | Preparation for regulating lower bowel function |
| WO2001052648A1 (en) * | 2000-01-19 | 2001-07-26 | University Of Pittsburgh | Improvements to artificial blood fluids and microflow drag reducing factors for enhanced blood circulation |
| US6777000B2 (en) * | 2001-02-28 | 2004-08-17 | Carrington Laboratories, Inc. | In-situ gel formation of pectin |
| US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
| WO2002082924A1 (en) * | 2001-04-10 | 2002-10-24 | Basf Health & Nutrition A/S | Microcapsules |
| WO2005095463A1 (en) | 2004-03-26 | 2005-10-13 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| PE20060468A1 (es) * | 2004-04-26 | 2006-07-06 | Cp Kelco Aps | Composicion dermoprotectora para controlar la alcalinidad de la piel que comprende polisacaridos de acido carboxilico |
| US8106000B2 (en) * | 2005-05-18 | 2012-01-31 | Da Volterra | Colonic delivery of adsorbents |
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1998
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1999
- 1999-05-12 AU AU38989/99A patent/AU3898999A/en not_active Abandoned
- 1999-05-12 WO PCT/US1999/010335 patent/WO1999058575A1/en not_active Ceased
- 1999-05-12 JP JP2000548377A patent/JP2002514663A/ja active Pending
- 1999-05-12 KR KR1020007012701A patent/KR100587423B1/ko not_active Expired - Fee Related
- 1999-05-12 DE DE69927498T patent/DE69927498T2/de not_active Expired - Lifetime
- 1999-05-12 CA CA2331744A patent/CA2331744C/en not_active Expired - Lifetime
- 1999-05-12 EP EP99921889A patent/EP1086141B1/en not_active Expired - Lifetime
- 1999-05-12 EP EP05077100A patent/EP1607407A3/en not_active Withdrawn
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| WO1999058575A1 (en) | 1999-11-18 |
| JP2002514663A (ja) | 2002-05-21 |
| EP1086141A1 (en) | 2001-03-28 |
| KR100587423B1 (ko) | 2006-06-08 |
| EP1607407A2 (en) | 2005-12-21 |
| EP1086141B1 (en) | 2005-09-28 |
| US5929051A (en) | 1999-07-27 |
| EP1607407A3 (en) | 2006-05-24 |
| DE69927498D1 (de) | 2006-02-09 |
| KR20010052346A (ko) | 2001-06-25 |
| CA2331744A1 (en) | 1999-11-18 |
| CA2331744C (en) | 2010-10-05 |
| AU3898999A (en) | 1999-11-29 |
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