DE69924369D1 - Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers - Google Patents

Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Info

Publication number
DE69924369D1
DE69924369D1 DE69924369T DE69924369T DE69924369D1 DE 69924369 D1 DE69924369 D1 DE 69924369D1 DE 69924369 T DE69924369 T DE 69924369T DE 69924369 T DE69924369 T DE 69924369T DE 69924369 D1 DE69924369 D1 DE 69924369D1
Authority
DE
Germany
Prior art keywords
fumarate
propylene
produced
propylene glycol
poly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69924369T
Other languages
German (de)
English (en)
Inventor
J Peter
J Suggs
Paul S Engel
Antonios G Mikos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
William Marsh Rice University
Original Assignee
William Marsh Rice University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Marsh Rice University filed Critical William Marsh Rice University
Application granted granted Critical
Publication of DE69924369D1 publication Critical patent/DE69924369D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation
    • C08G63/56—Polyesters derived from ester-forming derivatives of polycarboxylic acids or of polyhydroxy compounds other than from esters thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/12—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from polycarboxylic acids and polyhydroxy compounds
    • C08G63/52—Polycarboxylic acids or polyhydroxy compounds in which at least one of the two components contains aliphatic unsaturation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Composite Materials (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Materials For Medical Uses (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE69924369T 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers Expired - Fee Related DE69924369D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8140598P 1998-04-10 1998-04-10
US8130898P 1998-04-10 1998-04-10
US8218298P 1998-04-16 1998-04-16
PCT/US1999/007912 WO1999052469A1 (en) 1998-04-10 1999-04-09 Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger

Publications (1)

Publication Number Publication Date
DE69924369D1 true DE69924369D1 (de) 2005-04-28

Family

ID=27373944

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69924369T Expired - Fee Related DE69924369D1 (de) 1998-04-10 1999-04-09 Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Country Status (7)

Country Link
US (2) US6124373A (enExample)
EP (1) EP1079869B1 (enExample)
JP (1) JP2002539275A (enExample)
AT (1) ATE291444T1 (enExample)
CA (1) CA2327730A1 (enExample)
DE (1) DE69924369D1 (enExample)
WO (1) WO1999052469A1 (enExample)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6486232B1 (en) * 1997-04-18 2002-11-26 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for internal fixation devices and bone cements
DE69924369D1 (de) 1998-04-10 2005-04-28 Univ Rice William M Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers
KR100619611B1 (ko) * 1999-04-16 2006-09-01 더블유엠. 마쉬 라이스 유니버시티 작용화 폴리(프로필렌 푸마레이트) 및 폴리(프로필렌푸마레이트-코-에틸렌 글리콜
US6884778B2 (en) * 2000-04-14 2005-04-26 William Marsh Rice University Biocompatible macromers
DE10032220A1 (de) * 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium-ammonium-phosphat-Zemente, deren Herstellung und Verwendung
WO2002085246A2 (en) * 2001-04-19 2002-10-31 Case Western Reserve University Fabrication of a polymeric prosthetic implant
ATE393183T1 (de) * 2001-06-28 2008-05-15 Univ Wm Marsh Rice Photoquervernetzung von biologischen materialien aus fumarsäurediethylester/poly(propylenfumarat)
US7629388B2 (en) 2001-11-20 2009-12-08 William Marsh Rice University Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion
US20030180344A1 (en) * 2002-02-05 2003-09-25 Cambridge Scientific, Inc. Bioresorbable osteoconductive compositions for bone regeneration
US6884432B2 (en) * 2002-04-25 2005-04-26 Mayo Foundation For Medical Education And Research Blend, cross-linkable poly(propylene fumarate) for immobilization and controlled drug delivery
US7273523B2 (en) * 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
US20070065652A1 (en) * 2003-03-13 2007-03-22 Willaim Marsh Rice University Composite injectable and pre-fabricated bone replacement material and method for the production of such bone replacement material
ES2353689T5 (es) 2003-03-14 2014-08-18 Depuy Spine, Inc. Dispositivo hidráulico de inyección de cemento óseo en vertebroplastia percutánea
US8066713B2 (en) 2003-03-31 2011-11-29 Depuy Spine, Inc. Remotely-activated vertebroplasty injection device
US8415407B2 (en) 2004-03-21 2013-04-09 Depuy Spine, Inc. Methods, materials, and apparatus for treating bone and other tissue
EP1646670B1 (en) * 2003-07-01 2014-02-26 Mayo Foundation For Medical Education And Research Self-crosslinkable poly(caprolactone fumarate)
US7252686B2 (en) * 2003-08-13 2007-08-07 Boston Scientific Scimed Methods for reducing bone compression fractures using wedges
WO2005030034A2 (en) 2003-09-26 2005-04-07 Depuy Spine, Inc. Device for delivering viscous material
US20060018949A1 (en) * 2004-04-07 2006-01-26 Bausch & Lomb Incorporated Injectable biodegradable drug delivery system
JP2007534449A (ja) 2004-04-27 2007-11-29 カイフォン インコーポレイテッド 骨代替組成物および使用方法
EP1786343B1 (en) 2004-07-30 2012-05-02 Depuy Spine, Inc. Apparatus for treating bone and other tissue
US9255178B2 (en) * 2004-11-12 2016-02-09 Mayo Foundation For Medical Education And Research Photocrosslinkable poly (caprolactone fumarate)
AU2005306295B2 (en) * 2004-11-18 2011-06-16 Mayo Foundation For Medical Education And Research Block copolymers of polycaprolactone and poly (propylene fumarate)
JP5527968B2 (ja) * 2005-04-29 2014-06-25 メイヨ フオンデーシヨン フオー メデイカル エジユケーシヨン アンド リサーチ ポリ（カプロラクトンフマレート）、ポリ（エチレングリコールフマレート）およびそれらのコポリマーに基づく親水性／疎水性ポリマーネットワーク
US9381024B2 (en) 2005-07-31 2016-07-05 DePuy Synthes Products, Inc. Marked tools
US9918767B2 (en) 2005-08-01 2018-03-20 DePuy Synthes Products, Inc. Temperature control system
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US8360629B2 (en) 2005-11-22 2013-01-29 Depuy Spine, Inc. Mixing apparatus having central and planetary mixing elements
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
ES2547854T3 (es) * 2006-06-29 2015-10-09 Depuy Spine, Inc. Biopsia de hueso integrada y aparato de terapia
AU2007297097A1 (en) 2006-09-14 2008-03-20 Depuy Spine, Inc. Bone cement and methods of use thereof
EP2068950B1 (en) * 2006-09-21 2012-06-20 Kyphon SÀRL Diammonium phosphate and other ammonium salts and their use in preventing clotting
WO2008047371A2 (en) * 2006-10-19 2008-04-24 Depuy Spine, Inc. Fluid delivery system
US20080195223A1 (en) * 2006-11-03 2008-08-14 Avram Allan Eddin Materials and Methods and Systems for Delivering Localized Medical Treatments
ATE551967T1 (de) * 2007-07-30 2012-04-15 Purzer Pharmaceutical Co Ltd Biologisch abbaubarer knochenzement und herstellungsverfahren dafür
US20090286907A1 (en) * 2008-01-23 2009-11-19 Beltz Mark W Fumaric Acid/Diol Polyesters and Their Manufacture and Use
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
EP2590605A1 (en) 2010-07-09 2013-05-15 Board of Regents of the University of Texas System Biodegradable scaffolds
CA2808535C (en) 2010-08-20 2017-10-03 Case Western Reserve University Continuous digital light processing additive manufacturing of implants
US11865785B2 (en) * 2010-08-20 2024-01-09 H. David Dean Continuous digital light processing additive manufacturing of implants
CN106470703B (zh) 2014-05-05 2022-01-11 先进医疗解决方案以色列(西兰迪斯)公司 生物粘连剂和密封剂以及其使用方法
KR102527453B1 (ko) * 2014-11-18 2023-04-28 더 유니버시티 오브 아크론 잘 정의된 분해성 폴리 (프로필렌 푸마르산염) 중합체 및 이의 합성을 위한 확장 가능한 방법
KR20190112100A (ko) 2017-02-02 2019-10-02 더 유니버시티 오브 아크론 마그네슘 촉매를 사용하는 개환 중합에 의해 제조된 작용화된 폴리(프로필렌 푸마레이트) 중합체
GB2594243A (en) * 2020-04-15 2021-10-27 Arterius Ltd A bone cement
CN116137817A (zh) * 2020-07-15 2023-05-19 阿克伦大学 通过对聚(马来酸丙二醇酯)双键进行由锌和乙酸介导的时间依赖性还原来合成聚(马来酸丙二醇酯-共-琥珀酸酯)

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701748A (en) 1966-07-20 1972-10-31 Rohm & Haas Unsaturated polyester resinous compositions
GB1225803A (enExample) * 1967-06-02 1971-03-24
US5286763A (en) * 1983-03-22 1994-02-15 Massachusetts Institute Of Technology Bioerodible polymers for drug delivery in bone
US4722948A (en) * 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US5989579A (en) 1986-10-02 1999-11-23 Escalon Medical Corp. Ocular insert with anchoring protrusions
US4843112A (en) * 1987-03-12 1989-06-27 The Beth Israel Hospital Association Bioerodable implant composition
US4888413A (en) 1988-01-11 1989-12-19 Domb Abraham J Poly(propylene glycol fumarate) compositions for biomedical applications
FI904598A7 (fi) 1989-10-10 1991-04-11 Wrigley W M Jun Co Kuidunkehruutekniikalla valmistetut ainetta vähitellen vapauttavat rakenteet
FR2661682B1 (fr) 1990-05-04 1993-12-10 Norsolor Nouvelles compositions resineuses a base de resines polyesters non saturees et de nouveaux additifs anti-retrait.
BR9306038A (pt) 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5733951A (en) * 1994-04-28 1998-03-31 Yaszemski; Michael J. Poly(propylene fumarate)
US5527864A (en) * 1995-08-08 1996-06-18 Suggs; Laura J. Poly(propylene fumarate-co-ethylene oxide)
US5946457A (en) 1995-12-25 1999-08-31 Sharp Kabushiki Kaisha Image forming system having transfer device for communicating between image forming apparatus and image processing apparatus
US5998362A (en) 1996-09-12 1999-12-07 Merck & Co., Inc. Conjugates useful in the treatment of prostate cancer
US6071982A (en) 1997-04-18 2000-06-06 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys for surgical plates and bone cements, and method for making same
US5854382A (en) 1997-08-18 1998-12-29 Meadox Medicals, Inc. Bioresorbable compositions for implantable prostheses
DE69924369D1 (de) 1998-04-10 2005-04-28 Univ Rice William M Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers

Also Published As

Publication number Publication date
EP1079869A4 (en) 2002-08-07
ATE291444T1 (de) 2005-04-15
EP1079869A1 (en) 2001-03-07
US6355755B1 (en) 2002-03-12
WO1999052469A9 (en) 2000-03-23
EP1079869B1 (en) 2005-03-23
CA2327730A1 (en) 1999-10-21
WO1999052469A1 (en) 1999-10-21
US6124373A (en) 2000-09-26
JP2002539275A (ja) 2002-11-19

Similar Documents

Publication Publication Date Title
DE69924369D1 (de) Synthese von poly(propylenfumarat)durch azetylierung von propylenglykol in anwesenheit eines protonenfängers
Inoue et al. Stereochemistry of copolymerization of carbon dioxide with epoxycyclohexane
IE43223B1 (en) Production of dialkyl carbonate
IT1130285B (it) Procedimento per la sintesi di allil carbonati di alcoli poliidrici e loro derivati
KR960022492A (ko) N-보호 아미노산 에스테르로부터 n-보호 아미노산 알파-할로메틸케톤 및 알코올의 제조방법
AU2001281990A1 (en) Process for producing polytrimethylene terephthalate
EP0832913A4 (en) RANDOM SILOXANE COPOLYMER, PROCESS FOR PRODUCING THE SAME, AND RESIN COMPOSITION CONTAINING THE SAME
KR840001575A (ko) 면역 조절작용을 가진 화합물의 제조방법
JP3413279B2 (ja) フェノール性水酸基含有ラクトン開環重合体およびその製造方法
US3359242A (en) Process for producing high molecular weight (cyclo) aliphatic polyesters of carbonicacid with (cyclo) glycols
CN1144798C (zh) 氧杂环丁烷的制备方法
WO1998048040A1 (fr) Procede de preparation d'acetals de l-allysine
US4483994A (en) Process for the production of alkylene carbonates and oxides
JPS6133180A (ja) エポキシ化合物の製造方法
KR20240158249A (ko) 폴리에틸렌 글리콜의 활성 탄산 에스테르의 제조 방법, 및 폴리에틸렌 글리콜의 활성 탄산 에스테르
US4996315A (en) Novel synthesis of cyclic compounds
JP2876929B2 (ja) 光学活性１，３−ジオールの製法
JPS61118349A (ja) ジアルキルカ−ボネ−トの製造方法
US3506623A (en) Process for producing high molecular weight (cyclo) aliphatic polyesters of carbonic acid with (cyclo) glycols
JP2000080160A (ja) 酵素法によるポリ（アルキレンカーボネート）の製造方法
CN110327977B (zh) 一种铝锂双金属催化剂及其制备方法和应用
JPH0694459B2 (ja) 非共役系不飽和結合を有するペルオキシジカーボネート
JPS61176580A (ja) 光学活性３，４−エポキシ−１−ブタノ−ルの製法
Matsuda Synthesis of polyesters by using divalent metal salts of monohydroxyethyl phthalate: Metal‐containing polyesters from such metal salts, anhydride, and epoxide
Nakagawa et al. Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V

Legal Events

Date Code Title Description
8339 Ceased/non-payment of the annual fee