DE69919849D1 - Verfahren zur herstellung eines n-substituierten heterocyclischen derivats unterverwendung eines phasentransfer-katalysators - Google Patents

Verfahren zur herstellung eines n-substituierten heterocyclischen derivats unterverwendung eines phasentransfer-katalysators

Info

Publication number
DE69919849D1
DE69919849D1 DE69919849T DE69919849T DE69919849D1 DE 69919849 D1 DE69919849 D1 DE 69919849D1 DE 69919849 T DE69919849 T DE 69919849T DE 69919849 T DE69919849 T DE 69919849T DE 69919849 D1 DE69919849 D1 DE 69919849D1
Authority
DE
Germany
Prior art keywords
substituted heterocyclic
phase transfer
producing
transfer catalyst
heterocyclic derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69919849T
Other languages
English (en)
Other versions
DE69919849T2 (de
Inventor
G Anderson
Rajendra Deshpande
L Moniot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE69919849D1 publication Critical patent/DE69919849D1/de
Publication of DE69919849T2 publication Critical patent/DE69919849T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69919849T 1998-01-30 1999-01-20 Verfahren zur Herstellung eines N-substituierten heterocyclischen Derivats unter Verwendung eines Phasentransferkatalysators Expired - Lifetime DE69919849T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7310398P 1998-01-30 1998-01-30
US73103P 1998-01-30
PCT/US1999/001201 WO1999038847A1 (en) 1998-01-30 1999-01-20 Method for preparing n-substituted heterocyclic derivatives using a phase-transfer catalyst

Publications (2)

Publication Number Publication Date
DE69919849D1 true DE69919849D1 (de) 2004-10-07
DE69919849T2 DE69919849T2 (de) 2005-09-22

Family

ID=22111745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69919849T Expired - Lifetime DE69919849T2 (de) 1998-01-30 1999-01-20 Verfahren zur Herstellung eines N-substituierten heterocyclischen Derivats unter Verwendung eines Phasentransferkatalysators

Country Status (15)

Country Link
US (1) US6162922A (de)
EP (1) EP1060165B1 (de)
JP (2) JP4441114B2 (de)
KR (1) KR100546530B1 (de)
AT (1) ATE275135T1 (de)
AU (1) AU743018B2 (de)
CA (1) CA2318791A1 (de)
DE (1) DE69919849T2 (de)
DK (1) DK1060165T3 (de)
ES (1) ES2228006T3 (de)
HU (1) HU226770B1 (de)
IL (1) IL136357A (de)
PT (1) PT1060165E (de)
TW (1) TWI229076B (de)
WO (1) WO1999038847A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218680B (hu) * 1997-07-25 2000-10-30 Sanofi-Synthelabo Eljárás 1,3-diaza-spiro[4,4]non-1-én-4-on-származékok előállítására és 1-ciano-1-(acil-amino)-ciklopentán intermedierek
WO2004007482A2 (en) * 2002-07-16 2004-01-22 Teva Pharmaceutical Industries Ltd. Novel synthesis of irbesartan
WO2005051943A1 (en) * 2003-11-28 2005-06-09 Ranbaxy Laboratories Limited Processes for the preparation of highly pure irbesartan
EP1751123A4 (de) * 2004-05-20 2010-06-30 Reddys Lab Ltd Dr Verfahren zur herstellung von irbesartan
DE602005025755D1 (de) 2004-06-04 2011-02-17 Teva Pharma Irbesartan enthaltende pharmazeutische zusammensetzung
SI21848A (sl) * 2004-07-29 2006-02-28 Krka, Tovarna Zdravil, D.D., Novo Mesto Priprava seskvihidratne hidrokloridne soli tetrazolskega derivata
TWI346108B (en) * 2004-08-23 2011-08-01 Bristol Myers Squibb Co A method for preparing irbesartan and intermediates thereof
GB2419592A (en) * 2004-10-26 2006-05-03 Cipla Ltd Process for the preparation of irbesartan hydrochloride
ES2259909B1 (es) * 2005-02-28 2007-06-16 Inke, S.A. Procedimiento para la obtencion de un compuesto farmaceuticamente activo y de su intermedio de sintesis.
EP1951714A1 (de) * 2005-07-27 2008-08-06 Jubilant Organosys Limited Verfahren zur herstellung von 2-(n-butyl)-3-[[2'-(tetrazol-5-yl)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-on
EP1764365A1 (de) * 2005-09-20 2007-03-21 KRKA, D.D., Novo Mesto Verfahren zur Herstellung Sartanderivate und Zwischenprodukte für dieses Verfahren
ES2371910T3 (es) 2006-04-07 2012-01-11 Lek Pharmaceuticals D.D. Procedimiento para la preparación de irbesartán puro.
CN100413853C (zh) * 2006-09-21 2008-08-27 浙江海正药业股份有限公司 厄贝沙坦的合成中间体及其制备方法和制备药物的用途
WO2008087401A1 (en) * 2007-01-18 2008-07-24 Rainbow Engineering Services Sulfate salts of irbesartan and their preparation and pharmaceutical compositions
US7671273B2 (en) 2007-10-09 2010-03-02 International Business Machines Corporation Method and apparatus for facilitating signal transmission using differential transmission lines
WO2010116380A2 (en) * 2009-04-08 2010-10-14 Ctx Life Sciences Pvt. Ltd. A one pot process for preparing 2-butyl-3-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1,3-diazaspiro [4, 4] non-1-en-4-one (irbesartan)
CN101781287B (zh) * 2010-03-26 2013-03-20 天津大学 一种厄贝沙坦氢溴酸盐及其制备方法
CN110487931A (zh) * 2019-08-21 2019-11-22 浙江华海药业股份有限公司 一种(e)-4-苯基-4-氧代-2-丁烯酸乙酯的分析方法
WO2022094148A1 (en) * 2020-10-30 2022-05-05 Encodia, Inc. Conjugation reagents and methods using 1,2-cyclohexanediones

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270317A (en) * 1990-03-20 1993-12-14 Elf Sanofi N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present
PT97078B (pt) * 1990-03-20 1997-07-31 Sanofi Sa Processo para a preparacao de derivados heterociclicos n-substituidos e de composicoes farmaceuticas que os contem
IL99372A0 (en) * 1990-09-10 1992-08-18 Ciba Geigy Ag Azacyclic compounds
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
FR2673427B1 (fr) * 1991-03-01 1993-06-18 Sanofi Elf Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
AU2496492A (en) * 1991-08-19 1993-03-16 E.I. Du Pont De Nemours And Company Angiotensin ii receptor blocking imidazolinone derivatives
FR2688781B1 (fr) * 1992-03-23 1994-07-01 Sanofi Elf Imidazolines n-substituees par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant.
FR2689887B1 (fr) * 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.
JP2707390B2 (ja) * 1992-05-22 1998-01-28 壽製薬株式会社 シクロヘプトイミダゾ−ル誘導体及びその製造方法並びにこれを含有する薬剤
US5612363A (en) * 1995-06-02 1997-03-18 Berlex Laboratories, Inc. N,N-di(aryl) cyclic urea derivatives as anti-coagulants

Also Published As

Publication number Publication date
CA2318791A1 (en) 1999-08-05
DE69919849T2 (de) 2005-09-22
TWI229076B (en) 2005-03-11
KR100546530B1 (ko) 2006-01-26
AU743018B2 (en) 2002-01-17
PT1060165E (pt) 2004-12-31
JP4441114B2 (ja) 2010-03-31
EP1060165B1 (de) 2004-09-01
ES2228006T3 (es) 2005-04-01
JP2002501946A (ja) 2002-01-22
HU226770B1 (en) 2009-09-28
US6162922A (en) 2000-12-19
EP1060165A4 (de) 2002-07-31
AU2461599A (en) 1999-08-16
WO1999038847A1 (en) 1999-08-05
HUP0100898A2 (hu) 2002-02-28
EP1060165A1 (de) 2000-12-20
HUP0100898A3 (en) 2002-03-28
JP2010018638A (ja) 2010-01-28
IL136357A (en) 2004-07-25
ATE275135T1 (de) 2004-09-15
KR20010034477A (ko) 2001-04-25
DK1060165T3 (da) 2004-11-22

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