DE69917625T2 - Implantate zur verabreichung von wirkstoffen und verfahren zum herstellen von implantaten - Google Patents
Implantate zur verabreichung von wirkstoffen und verfahren zum herstellen von implantaten Download PDFInfo
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- DE69917625T2 DE69917625T2 DE69917625T DE69917625T DE69917625T2 DE 69917625 T2 DE69917625 T2 DE 69917625T2 DE 69917625 T DE69917625 T DE 69917625T DE 69917625 T DE69917625 T DE 69917625T DE 69917625 T2 DE69917625 T2 DE 69917625T2
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Classifications
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| GB9808052 | 1998-04-17 | ||
| GBGB9808052.6A GB9808052D0 (en) | 1998-04-17 | 1998-04-17 | Implants for administering substances and methods of producing implants |
| PCT/GB1999/001185 WO1999053898A1 (en) | 1998-04-17 | 1999-04-16 | Implants for administering substances and methods of producing implants |
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Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9808052D0 (en) * | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
| GB9924334D0 (en) * | 1999-10-15 | 1999-12-15 | Secr Defence | Pharmaceutical products and methods of fabrication therefor |
| GB0008494D0 (en) | 2000-04-07 | 2000-05-24 | Secr Defence | Microprojectile delivery system |
| AU2005200352B2 (en) * | 2000-06-10 | 2008-05-15 | Psimedica Limited | A porous and/or polycrystalline silicon orthopaedic implant |
| GB2363115A (en) * | 2000-06-10 | 2001-12-12 | Secr Defence | Porous or polycrystalline silicon orthopaedic implants |
| GB2365769A (en) * | 2000-08-18 | 2002-02-27 | Secr Defence | Skin preparations containing silicon |
| JP2006500115A (ja) | 2000-11-16 | 2006-01-05 | マイクロスフエリツクス・エル・エル・シー | 密封小線源治療用の可撓性および／または弾性シードまたはストランド |
| GB0104383D0 (en) * | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
| KR101191254B1 (ko) * | 2002-03-11 | 2012-10-16 | 알콘, 인코퍼레이티드 | 이식 가능한 약물 전달 시스템 |
| US20070042046A1 (en) * | 2003-10-21 | 2007-02-22 | Roghieh Saffie | Methods for the treatment of cancer |
| GB0324483D0 (en) * | 2003-10-21 | 2003-11-19 | Psi Medica Ltd | Composite material |
| DE102004021739B4 (de) * | 2004-04-30 | 2007-11-22 | Heraeus Kulzer Gmbh | Metallimplantat mit Oberflächenbeschichtung |
| US8709469B2 (en) * | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
| CN101072580B (zh) | 2004-10-06 | 2012-08-22 | 农业生物技术有限公司 | 抗体制备方法 |
| ES2669585T3 (es) | 2004-10-29 | 2018-05-28 | The Regents Of The University Of California | Micropartículas porosas de silicio para la entrega de fármaco para el ojo |
| US20070009564A1 (en) * | 2005-06-22 | 2007-01-11 | Mcclain James B | Drug/polymer composite materials and methods of making the same |
| CN105233349B (zh) | 2005-07-15 | 2019-06-18 | 胶束技术股份有限公司 | 包含受控形态的药物粉末的聚合物涂层 |
| WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
| GB0519391D0 (en) * | 2005-09-22 | 2005-11-02 | Aion Diagnostics Ltd | Imaging agents |
| AU2007243268B2 (en) | 2006-04-26 | 2013-06-13 | Micell Technologies, Inc. | Coatings containing multiple drugs |
| US20080051335A1 (en) * | 2006-05-02 | 2008-02-28 | Kleiner Lothar W | Methods, compositions and devices for treating lesioned sites using bioabsorbable carriers |
| CN101678388B (zh) | 2006-10-23 | 2013-12-11 | 米歇尔技术公司 | 用于在涂覆过程中为基底充电的保持器 |
| EP2111184B1 (en) | 2007-01-08 | 2018-07-25 | Micell Technologies, Inc. | Stents having biodegradable layers |
| US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
| CA2688314C (en) | 2007-05-25 | 2013-12-03 | Micell Technologies, Inc. | Polymer films for medical device coating |
| KR20100047258A (ko) | 2007-07-10 | 2010-05-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 선택된 조직에 조성물을 전달하는 물질 및 방법 |
| AU2009251504B2 (en) | 2008-04-17 | 2013-09-05 | Micell Technologies, Inc. | Stents having bioabsorbable layers |
| EP2313122B1 (en) | 2008-07-17 | 2019-03-06 | Micell Technologies, Inc. | Drug delivery medical device |
| US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
| US20110300222A1 (en) * | 2009-02-20 | 2011-12-08 | The Regents Of The University Of California | Luminescent porous silicon nanoparticles, methods of making and using same |
| WO2010120552A2 (en) | 2009-04-01 | 2010-10-21 | Micell Technologies, Inc. | Coated stents |
| EP3366326A1 (en) | 2009-04-17 | 2018-08-29 | Micell Technologies, Inc. | Stents having controlled elution |
| CA2758607C (en) | 2009-05-04 | 2018-05-15 | Psivida Us, Inc. | Porous silicon drug-eluting particles |
| EP2453834A4 (en) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | MEDICAL DEVICE DISPENSING MEDICINE |
| CN102281906B (zh) * | 2009-08-25 | 2014-08-27 | 株式会社医技中心 | 医疗用部件及其制造方法 |
| WO2011097103A1 (en) | 2010-02-02 | 2011-08-11 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
| WO2011156028A2 (en) | 2010-03-09 | 2011-12-15 | Board Of Regents Of The University Of Texas System | Porous and non-porous nanostructures |
| US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
| CA2797110C (en) | 2010-04-22 | 2020-07-21 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
| US20130184835A1 (en) | 2010-07-09 | 2013-07-18 | Board Of Regents Of The Unversity Of Texas System | Biodegradable scaffolds |
| CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
| WO2012034079A2 (en) | 2010-09-09 | 2012-03-15 | Micell Technologies, Inc. | Macrolide dosage forms |
| CN104622789A (zh) | 2010-11-01 | 2015-05-20 | 普西维达公司 | 用于递送治疗剂的可生物侵蚀的硅基装置 |
| US8679093B2 (en) | 2010-11-23 | 2014-03-25 | Microchips, Inc. | Multi-dose drug delivery device and method |
| WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
| CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
| US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
| US20140205971A1 (en) * | 2013-01-18 | 2014-07-24 | The Trustees Of The Stevens Institute Of Technology | Modification of root form dental implants for accelerated tissue regeneration |
| KR20150143476A (ko) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
| HK1216720A1 (zh) | 2013-03-15 | 2016-12-02 | Psi医疗有限公司 | 用於递送治疗剂的可生物蚀解的硅基组合物 |
| HK1222313A1 (zh) | 2013-05-15 | 2017-06-30 | Micell Technologies, Inc. | 可生物吸收的生物医学植入物 |
| JP6894423B2 (ja) | 2015-07-09 | 2021-06-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 融合性リポソーム被覆多孔質ケイ素ナノ粒子 |
| US20210177770A1 (en) | 2016-04-14 | 2021-06-17 | Spinnaker Biosciences, Inc. | Porous silicon materials comprising a metal silicate for delivery of therapeutic agents |
| BR112020023983A2 (pt) | 2018-05-24 | 2021-02-23 | Celanese Eva Performance Polymers Llc | dispositivo implantável para liberação prolongada de um composto de fármaco macromolecular |
| US11690806B2 (en) | 2018-05-24 | 2023-07-04 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
| EP3803866A4 (en) | 2018-05-24 | 2022-03-16 | Nureva Inc. | METHOD, APPARATUS, AND COMPUTER READABLE MATERIALS FOR MANAGING SEMI-CONSTANT (PERSISTENT) SOUND SOURCES IN MICROPHONE CATCH/HOME AREAS |
| CA3105045A1 (en) * | 2018-06-25 | 2020-01-02 | Titan Pharmaceuticals, Inc. | Loadable porous structures for use as implants |
| WO2022231930A1 (en) | 2021-04-26 | 2022-11-03 | Celanese Eva Performance Polymers Llc | Implantable device for sustained release of a macromolecular drug compound |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3832458A (en) * | 1971-12-06 | 1974-08-27 | River C Foundation | Hydrophilic silicone composition and method |
| US4036979A (en) * | 1974-01-25 | 1977-07-19 | American Cyanamid Company | Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate |
| US3919723A (en) * | 1974-05-20 | 1975-11-18 | Friedrichsfeld Gmbh | Bone shaft or bone joint prosthesis and process |
| US3919060A (en) * | 1974-06-14 | 1975-11-11 | Ibm | Method of fabricating semiconductor device embodying dielectric isolation |
| JPS59101145A (ja) | 1982-11-30 | 1984-06-11 | 日本特殊陶業株式会社 | 薬液含浸多孔質セラミツクス |
| JPS59131346A (ja) * | 1983-01-17 | 1984-07-28 | 日本特殊陶業株式会社 | 薬液含浸多孔質セラミツクスの製造法 |
| DE3423667A1 (de) | 1984-05-08 | 1985-11-28 | Rüdiger Dipl.-Ing. 5204 Lohmar Scheunemann | Implantat fuer knochen- und zahnwurzelersatz mit spezieller uebergangsstruktur zwischen knochen und implantatkern und knochenseitig ganz oder teilweise resorbierbarer matrix |
| GB8422876D0 (en) | 1984-09-11 | 1984-10-17 | Secr Defence | Silicon implant devices |
| US4608048A (en) * | 1984-12-06 | 1986-08-26 | Alza Corporation | Dispensing device with drug delivery patterns |
| US5057082A (en) | 1988-11-04 | 1991-10-15 | Plastic Injectors, Inc. | Trocar assembly |
| AU634529B2 (en) | 1989-03-17 | 1993-02-25 | Pitman-Moore, Inc. | Controlled release delivery device for macromolecular proteins |
| GB8927709D0 (en) | 1989-12-07 | 1990-02-07 | Secretary Of The State For Def | Silicon quantum wires |
| US5167625A (en) | 1990-10-09 | 1992-12-01 | Sarcos Group | Multiple vesicle implantable drug delivery system |
| US5366454A (en) | 1993-03-17 | 1994-11-22 | La Corporation De L'ecole Polytechnique | Implantable medication dispensing device |
| US5370630A (en) | 1993-11-12 | 1994-12-06 | Smidebush; Michael J. | Device for injection of fluidic materials into body tissue |
| US5817327A (en) | 1994-07-27 | 1998-10-06 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| US5591453A (en) * | 1994-07-27 | 1997-01-07 | The Trustees Of The University Of Pennsylvania | Incorporation of biologically active molecules into bioactive glasses |
| US5665114A (en) | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
| US5792099A (en) | 1995-02-14 | 1998-08-11 | Decamp; Dennis | Syringe and cannula for insertion of viscoelastic material into an eye and method of using same |
| JP3768536B2 (ja) | 1995-04-03 | 2006-04-19 | アボツト・ラボラトリーズ | 低温溶融性薬物と制御放出のための添加物との均質混合物 |
| US6096344A (en) | 1995-07-28 | 2000-08-01 | Advanced Polymer Systems, Inc. | Bioerodible porous compositions |
| GB9611437D0 (en) | 1995-08-03 | 1996-08-07 | Secr Defence | Biomaterial |
| US5665428A (en) | 1995-10-25 | 1997-09-09 | Macromed, Inc. | Preparation of peptide containing biodegradable microspheres by melt process |
| DE19608423A1 (de) * | 1996-03-05 | 1997-09-11 | Merck Patent Gmbh | Implantate mit phasenweiser Arzneistoffabgabe |
| US7070590B1 (en) | 1996-07-02 | 2006-07-04 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5797898A (en) * | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5922299A (en) * | 1996-11-26 | 1999-07-13 | Battelle Memorial Institute | Mesoporous-silica films, fibers, and powders by evaporation |
| JP3217286B2 (ja) | 1996-12-19 | 2001-10-09 | 科学技術振興事業団 | Ｄｎａ固定化複合体 |
| US6696258B1 (en) * | 1998-01-20 | 2004-02-24 | Drexel University | Mesoporous materials and methods of making the same |
| US6060036A (en) * | 1998-02-09 | 2000-05-09 | Implant Sciences Corporation | Radioactive seed implants |
| GB9808052D0 (en) | 1998-04-17 | 1998-06-17 | Secr Defence | Implants for administering substances and methods of producing implants |
| GB9815819D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| IL143846A0 (en) | 1998-12-23 | 2002-04-21 | Alza Corp | Dosage forms comprising porous particles |
| WO2001012221A1 (en) | 1999-08-16 | 2001-02-22 | Henceforth Hibernia, Inc. | Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them |
| GB9924334D0 (en) | 1999-10-15 | 1999-12-15 | Secr Defence | Pharmaceutical products and methods of fabrication therefor |
| KR20020064299A (ko) | 1999-10-18 | 2002-08-07 | 퍽스 인코포레이티드 | 자기 표적화형 캐리어 |
| SE9903958D0 (sv) | 1999-11-02 | 1999-11-02 | Boerje Sellergren | Porous materials for selective binding or transport of molecular guests |
| US6521284B1 (en) | 1999-11-03 | 2003-02-18 | Scimed Life Systems, Inc. | Process for impregnating a porous material with a cross-linkable composition |
| AUPQ573300A0 (en) | 2000-02-21 | 2000-03-16 | Australian Nuclear Science & Technology Organisation | Controlled release ceramic particles, compositions thereof, processes of preparation and methods of use |
| CN1424912A (zh) | 2000-02-28 | 2003-06-18 | 阿文蒂斯药物股份有限公司 | 用于治疗癌症的含有喜树碱和嘧啶衍生物的组合物 |
| GB0008494D0 (en) | 2000-04-07 | 2000-05-24 | Secr Defence | Microprojectile delivery system |
| GB2365769A (en) | 2000-08-18 | 2002-02-27 | Secr Defence | Skin preparations containing silicon |
| GB0104383D0 (en) | 2001-02-22 | 2001-04-11 | Psimedica Ltd | Cancer Treatment |
| WO2002096389A1 (en) | 2001-05-30 | 2002-12-05 | Microchips, Inc. | Conformal coated microchip reservoir devices |
| CN1301692C (zh) | 2002-09-18 | 2007-02-28 | 阿勒根公司 | 眼植入物导入的器械 |
| WO2004071949A2 (en) | 2003-02-13 | 2004-08-26 | The Regents Of The University Of California | Nanostructured casting of organic and bio-polymers in porous silicon templates |
| US7433811B2 (en) | 2003-05-06 | 2008-10-07 | The Regents Of The University Of California | Direct patterning of silicon by photoelectrochemical etching |
| US7563451B2 (en) | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| GB0324483D0 (en) | 2003-10-21 | 2003-11-19 | Psi Medica Ltd | Composite material |
| US20070042046A1 (en) | 2003-10-21 | 2007-02-22 | Roghieh Saffie | Methods for the treatment of cancer |
| US20050181049A1 (en) | 2003-11-19 | 2005-08-18 | Dong Liang C. | Composition and method for enhancing bioavailability |
| JP2008513127A (ja) | 2004-09-17 | 2008-05-01 | オルムコ コーポレイション | 医療装置及び針製造方法 |
| US20060067979A1 (en) | 2004-09-30 | 2006-03-30 | Bausch & Lomb Incorporated | Ophthalmic drug release device for multiple drug release |
| WO2006037160A1 (en) | 2004-10-05 | 2006-04-13 | The University Of Melbourne | Porous polyelectrolyte materials |
| ES2669585T3 (es) | 2004-10-29 | 2018-05-28 | The Regents Of The University Of California | Micropartículas porosas de silicio para la entrega de fármaco para el ojo |
| JP4977475B2 (ja) | 2004-12-21 | 2012-07-18 | 日本電気株式会社 | フィルム外装電気デバイス用ケース |
| JP2007091716A (ja) | 2005-08-29 | 2007-04-12 | Kuraray Co Ltd | 水中薬剤徐放性微粒子及びその製造方法 |
| GB0526332D0 (en) | 2005-12-23 | 2006-02-01 | Psimedica Ltd | Pharmaceutical product |
| US8119394B2 (en) | 2006-03-14 | 2012-02-21 | University Of Rochester | Cell culture devices having ultrathin porous membrane and uses thereof |
| CA2648066C (en) | 2006-03-31 | 2012-07-03 | Forsight Labs, Llc | Drug delivery methods, structures, and compositions for nasolacrimal system |
| US9248121B2 (en) | 2006-08-21 | 2016-02-02 | Abbott Laboratories | Medical devices for controlled drug release |
| KR20100047258A (ko) | 2007-07-10 | 2010-05-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 선택된 조직에 조성물을 전달하는 물질 및 방법 |
| GB0817938D0 (en) | 2008-09-30 | 2008-11-05 | Intrinsiq Materials Global Ltd | Cosmetic formulations |
| GB0817936D0 (en) | 2008-09-30 | 2008-11-05 | Intrinsiq Materials Global Ltd | Porous materials |
| US20120045515A1 (en) | 2009-02-04 | 2012-02-23 | Ye Liu | Hollow silica particle with a polymer thereon |
| US20110300222A1 (en) | 2009-02-20 | 2011-12-08 | The Regents Of The University Of California | Luminescent porous silicon nanoparticles, methods of making and using same |
| JP5382700B2 (ja) | 2009-03-27 | 2014-01-08 | 独立行政法人産業技術総合研究所 | ロッド状多孔質シリカ粒子 |
| CA2758607C (en) | 2009-05-04 | 2018-05-15 | Psivida Us, Inc. | Porous silicon drug-eluting particles |
| CN104622789A (zh) | 2010-11-01 | 2015-05-20 | 普西维达公司 | 用于递送治疗剂的可生物侵蚀的硅基装置 |
| US20120238994A1 (en) | 2010-12-22 | 2012-09-20 | Martin Nazzaro | Two-piece injectable drug delivery device with heat-cured seal |
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1998
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1999
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