DE69906928T2 - Fettbindende polymere-lipasehemmer kombinationen zur behandlung von fettleibigkeit - Google Patents
Fettbindende polymere-lipasehemmer kombinationen zur behandlung von fettleibigkeit Download PDFInfo
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- DE69906928T2 DE69906928T2 DE69906928T DE69906928T DE69906928T2 DE 69906928 T2 DE69906928 T2 DE 69906928T2 DE 69906928 T DE69906928 T DE 69906928T DE 69906928 T DE69906928 T DE 69906928T DE 69906928 T2 DE69906928 T2 DE 69906928T2
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- SIKWOTFNWURSAY-UHFFFAOYSA-N Lipstatin Natural products CCCCCCC1C(CC(CC=CCC=CCCCCC)C(=O)OC(CC(C)C)NC=O)OC1=O SIKWOTFNWURSAY-UHFFFAOYSA-N 0.000 claims abstract description 6
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- OQMAKWGYQLJJIA-CUOOPAIESA-N lipstatin Chemical compound CCCCCC[C@H]1[C@H](C[C@H](C\C=C/C\C=C/CCCCC)OC(=O)[C@H](CC(C)C)NC=O)OC1=O OQMAKWGYQLJJIA-CUOOPAIESA-N 0.000 claims abstract description 6
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- XOJWAAUYNWGQAU-UHFFFAOYSA-N 4-(2-methylprop-2-enoyloxy)butyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCCCOC(=O)C(C)=C XOJWAAUYNWGQAU-UHFFFAOYSA-N 0.000 claims description 2
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- FHLPGTXWCFQMIU-UHFFFAOYSA-N [4-[2-(4-prop-2-enoyloxyphenyl)propan-2-yl]phenyl] prop-2-enoate Chemical compound C=1C=C(OC(=O)C=C)C=CC=1C(C)(C)C1=CC=C(OC(=O)C=C)C=C1 FHLPGTXWCFQMIU-UHFFFAOYSA-N 0.000 claims description 2
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- HADJJUAGACHKHO-UHFFFAOYSA-N n-(oxiran-2-ylmethyl)butanamide Chemical compound CCCC(=O)NCC1CO1 HADJJUAGACHKHO-UHFFFAOYSA-N 0.000 description 1
- XKWWQHSAOSKPJC-UHFFFAOYSA-N n-(oxiran-2-ylmethyl)hexanamide Chemical compound CCCCCC(=O)NCC1CO1 XKWWQHSAOSKPJC-UHFFFAOYSA-N 0.000 description 1
- UMLARORAEPLXTC-UHFFFAOYSA-N n-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;2-methyl-1-phenylpropan-2-amine Chemical compound CC(C)(N)CC1=CC=CC=C1.CCNC(C)CC1=CC=CC(C(F)(F)F)=C1 UMLARORAEPLXTC-UHFFFAOYSA-N 0.000 description 1
- 125000003136 n-heptyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229960003562 phentermine Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000000710 polymer precipitation Methods 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- XGVXKJKTISMIOW-ZDUSSCGKSA-N simurosertib Chemical compound N1N=CC(C=2SC=3C(=O)NC(=NC=3C=2)[C@H]2N3CCC(CC3)C2)=C1C XGVXKJKTISMIOW-ZDUSSCGKSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- XORCSVNTBYQSNV-UHFFFAOYSA-N tridecylazanium;bromide Chemical compound [Br-].CCCCCCCCCCCCC[NH3+] XORCSVNTBYQSNV-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
- A61K31/78—Polymers containing oxygen of acrylic acid or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyesters Or Polycarbonates (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Detergent Compositions (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US496398A | 1998-01-09 | 1998-01-09 | |
| US4963 | 1998-01-09 | ||
| US09/166,453 US6264937B1 (en) | 1998-01-09 | 1998-10-05 | Fat-binding polymers |
| US166453 | 1998-10-05 | ||
| PCT/US1999/000028 WO1999034787A2 (en) | 1998-01-09 | 1999-01-04 | Fat-binding polymers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69906928D1 DE69906928D1 (de) | 2003-05-22 |
| DE69906928T2 true DE69906928T2 (de) | 2004-02-19 |
Family
ID=26673719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69906928T Expired - Fee Related DE69906928T2 (de) | 1998-01-09 | 1999-01-04 | Fettbindende polymere-lipasehemmer kombinationen zur behandlung von fettleibigkeit |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP1043981B1 (enExample) |
| JP (1) | JP2002500183A (enExample) |
| KR (2) | KR100773625B1 (enExample) |
| CN (1) | CN1212123C (enExample) |
| AT (1) | ATE237349T1 (enExample) |
| AU (2) | AU740233B2 (enExample) |
| BR (1) | BR9907234A (enExample) |
| CA (1) | CA2318417A1 (enExample) |
| DE (1) | DE69906928T2 (enExample) |
| ES (1) | ES2200493T3 (enExample) |
| HU (1) | HUP0100890A3 (enExample) |
| IL (1) | IL137096A (enExample) |
| MX (1) | MX222446B (enExample) |
| NO (1) | NO20003510L (enExample) |
| NZ (2) | NZ505294A (enExample) |
| PL (1) | PL193452B1 (enExample) |
| RU (1) | RU2222335C2 (enExample) |
| WO (1) | WO1999034787A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6267952B1 (en) * | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| IL147361A0 (en) * | 1999-07-14 | 2002-08-14 | Geltex Pharma Inc | Fat-binding polymers, optionally combined with lipase inhibitors |
| CA2386036A1 (en) * | 1999-10-01 | 2001-04-12 | Yasukazu Nagato | Antiobesity agent |
| RU2241462C2 (ru) | 2000-07-28 | 2004-12-10 | Ф. Хоффманн-Ля Рош Аг | Новая фармацевтическая композиция |
| KR20040018359A (ko) * | 2001-04-18 | 2004-03-03 | 젠자임 코포레이션 | 지방족 폴리아민으로 ｘ 증후군을 치료하는 방법 |
| US8372430B2 (en) | 2002-12-17 | 2013-02-12 | The Procter & Gamble Company | Compositions, methods, and kits useful for the alleviation of gastrointestinal effects |
| SE0302253D0 (sv) * | 2003-08-21 | 2003-08-21 | Forskarpatent I Syd Ab | Lipase-colipase inhibitor |
| CN106176800B (zh) * | 2016-07-11 | 2019-12-06 | 韩源平 | 多聚阳离子树脂的制药应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7017227A (enExample) * | 1969-12-27 | 1971-06-29 | ||
| US4211765A (en) * | 1971-10-12 | 1980-07-08 | Monsanto Company | Method for controlling obesity |
| US4432968A (en) * | 1980-10-20 | 1984-02-21 | The Dow Chemical Company | Weight control with fat imbibing polymers |
| CA1213397A (en) * | 1980-10-20 | 1986-10-28 | Judith L. Page | Weight control with alkyl styrene polymers |
| JPH02503205A (ja) * | 1988-02-12 | 1990-10-04 | ドゥ ツァープフェル，ブリギット | 医用及びパラメディカル用の架橋親水性コポリマー |
| RU2066185C1 (ru) * | 1993-01-11 | 1996-09-10 | Институт пищевых веществ РАН | Гиполипидемический энтеросорбент |
| JP3507523B2 (ja) * | 1993-05-12 | 2004-03-15 | 積水化学工業株式会社 | 糖質吸収抑制剤 |
-
1999
- 1999-01-04 RU RU2000120918/14A patent/RU2222335C2/ru not_active IP Right Cessation
- 1999-01-04 BR BR9907234-3A patent/BR9907234A/pt not_active Application Discontinuation
- 1999-01-04 HU HU0100890A patent/HUP0100890A3/hu unknown
- 1999-01-04 AT AT99900369T patent/ATE237349T1/de not_active IP Right Cessation
- 1999-01-04 NZ NZ505294A patent/NZ505294A/xx unknown
- 1999-01-04 IL IL137096A patent/IL137096A/en active IP Right Grant
- 1999-01-04 PL PL343898A patent/PL193452B1/pl unknown
- 1999-01-04 JP JP2000527238A patent/JP2002500183A/ja active Pending
- 1999-01-04 DE DE69906928T patent/DE69906928T2/de not_active Expired - Fee Related
- 1999-01-04 KR KR1020007007608A patent/KR100773625B1/ko not_active Expired - Fee Related
- 1999-01-04 CA CA002318417A patent/CA2318417A1/en not_active Abandoned
- 1999-01-04 NZ NZ523301A patent/NZ523301A/en unknown
- 1999-01-04 ES ES99900369T patent/ES2200493T3/es not_active Expired - Lifetime
- 1999-01-04 CN CNB998020311A patent/CN1212123C/zh not_active Expired - Fee Related
- 1999-01-04 KR KR1020067021186A patent/KR20060111741A/ko not_active Ceased
- 1999-01-04 WO PCT/US1999/000028 patent/WO1999034787A2/en not_active Ceased
- 1999-01-04 EP EP99900369A patent/EP1043981B1/en not_active Expired - Lifetime
- 1999-01-04 AU AU19505/99A patent/AU740233B2/en not_active Ceased
-
2000
- 2000-07-06 MX MXPA00006681 patent/MX222446B/es active IP Right Grant
- 2000-07-07 NO NO20003510A patent/NO20003510L/no not_active Application Discontinuation
-
2002
- 2002-02-01 AU AU2002014755A patent/AU2002014755A1/xx not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ATE237349T1 (en) | 2003-05-15 |
| DE69906928D1 (de) | 2003-05-22 |
| MXPA00006681A (es) | 2001-02-01 |
| KR20010034013A (ko) | 2001-04-25 |
| IL137096A (en) | 2006-10-31 |
| NZ523301A (en) | 2005-11-25 |
| HUP0100890A3 (en) | 2001-12-28 |
| CA2318417A1 (en) | 1999-07-15 |
| KR100773625B1 (ko) | 2007-11-05 |
| EP1043981B1 (en) | 2003-04-16 |
| CN1212123C (zh) | 2005-07-27 |
| HUP0100890A2 (hu) | 2001-08-28 |
| HK1034044A1 (en) | 2001-10-12 |
| WO1999034787A3 (en) | 2000-01-20 |
| CN1288381A (zh) | 2001-03-21 |
| AU740233B2 (en) | 2001-11-01 |
| NO20003510L (no) | 2000-09-07 |
| NZ505294A (en) | 2003-02-28 |
| PL193452B1 (pl) | 2007-02-28 |
| AU2002014755A1 (en) | 2002-03-14 |
| BR9907234A (pt) | 2000-10-10 |
| IL137096A0 (en) | 2001-06-14 |
| EP1043981A2 (en) | 2000-10-18 |
| RU2222335C2 (ru) | 2004-01-27 |
| KR20060111741A (ko) | 2006-10-27 |
| AU1950599A (en) | 1999-07-26 |
| MX222446B (en) | 2004-09-01 |
| ES2200493T3 (es) | 2004-03-01 |
| PL343898A1 (en) | 2001-09-10 |
| NO20003510D0 (no) | 2000-07-07 |
| WO1999034787A2 (en) | 1999-07-15 |
| JP2002500183A (ja) | 2002-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: GENZYME CORP., CAMBRIDGE, MASS., US |
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| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |