DE69839294T2 - Gerät zur Abscheidung magnetischer Teilchen - Google Patents
Gerät zur Abscheidung magnetischer Teilchen Download PDFInfo
- Publication number
- DE69839294T2 DE69839294T2 DE69839294T DE69839294T DE69839294T2 DE 69839294 T2 DE69839294 T2 DE 69839294T2 DE 69839294 T DE69839294 T DE 69839294T DE 69839294 T DE69839294 T DE 69839294T DE 69839294 T2 DE69839294 T2 DE 69839294T2
- Authority
- DE
- Germany
- Prior art keywords
- carrier
- reaction vessel
- magnetic
- magnetic elements
- magnetic element
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006249 magnetic particle Substances 0.000 title claims description 56
- 238000000151 deposition Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 claims description 119
- 239000007788 liquid Substances 0.000 claims description 25
- 238000012545 processing Methods 0.000 claims description 12
- 238000003491 array Methods 0.000 claims description 4
- 239000000758 substrate Substances 0.000 claims 1
- 239000000969 carrier Substances 0.000 description 37
- 238000000926 separation method Methods 0.000 description 15
- 238000002386 leaching Methods 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- 239000000523 sample Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000002934 lysing effect Effects 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000008188 pellet Substances 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000009347 mechanical transmission Effects 0.000 description 3
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000005012 migration Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 230000006978 adaptation Effects 0.000 description 1
- 230000002301 combined effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97116857 | 1997-09-29 | ||
| EP97116857 | 1997-09-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69839294D1 DE69839294D1 (de) | 2008-05-08 |
| DE69839294T2 true DE69839294T2 (de) | 2009-04-09 |
Family
ID=8227406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69839294T Expired - Lifetime DE69839294T2 (de) | 1997-09-29 | 1998-07-08 | Gerät zur Abscheidung magnetischer Teilchen |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US6579453B1 (enExample) |
| JP (1) | JP4351751B2 (enExample) |
| DE (1) | DE69839294T2 (enExample) |
Families Citing this family (60)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6884357B2 (en) * | 1995-02-21 | 2005-04-26 | Iqbal Waheed Siddiqi | Apparatus and method for processing magnetic particles |
| US6048734A (en) | 1995-09-15 | 2000-04-11 | The Regents Of The University Of Michigan | Thermal microvalves in a fluid flow method |
| JP2001091521A (ja) * | 1999-09-21 | 2001-04-06 | Olympus Optical Co Ltd | 自動分析装置 |
| EP1282469B1 (en) * | 2000-05-19 | 2009-01-07 | Becton, Dickinson and Company | System and method for manipulating magnetically responsive particles in fluid samples to collect dna or rna from a sample |
| US6692700B2 (en) | 2001-02-14 | 2004-02-17 | Handylab, Inc. | Heat-reduction methods and systems related to microfluidic devices |
| US7323140B2 (en) | 2001-03-28 | 2008-01-29 | Handylab, Inc. | Moving microdroplets in a microfluidic device |
| US7829025B2 (en) | 2001-03-28 | 2010-11-09 | Venture Lending & Leasing Iv, Inc. | Systems and methods for thermal actuation of microfluidic devices |
| US8895311B1 (en) | 2001-03-28 | 2014-11-25 | Handylab, Inc. | Methods and systems for control of general purpose microfluidic devices |
| US6852287B2 (en) | 2001-09-12 | 2005-02-08 | Handylab, Inc. | Microfluidic devices having a reduced number of input and output connections |
| US7010391B2 (en) | 2001-03-28 | 2006-03-07 | Handylab, Inc. | Methods and systems for control of microfluidic devices |
| AU2003226075B2 (en) | 2002-04-12 | 2008-09-25 | Instrumentation Laboratory Company | Immunoassay probe |
| USD502450S1 (en) * | 2002-04-23 | 2005-03-01 | Bio-Nobile Oy | Transfer device for magnetic particles |
| WO2003090897A1 (en) * | 2002-04-26 | 2003-11-06 | Abbott Laboratories | Structure and method for handling magnetic particles in biological assays |
| JP4996248B2 (ja) | 2003-07-31 | 2012-08-08 | ハンディーラブ インコーポレイテッド | 粒子含有サンプルの処理 |
| US8852862B2 (en) | 2004-05-03 | 2014-10-07 | Handylab, Inc. | Method for processing polynucleotide-containing samples |
| CA2994321C (en) | 2004-05-03 | 2023-08-08 | Handylab, Inc. | A microfluidic device and methods for processing polynucleotide-containing samples |
| US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| JP2008511816A (ja) * | 2004-08-03 | 2008-04-17 | ベクトン・ディキンソン・アンド・カンパニー | サンプルを分別するための磁性材料の使用 |
| JP2006281133A (ja) * | 2005-04-01 | 2006-10-19 | Tokyo Institute Of Technology | 磁気ビーズセパレータ |
| US20100213136A1 (en) * | 2005-06-23 | 2010-08-26 | Koninklijke Philips Electronics, N.V. | Apparatus for moving magnetic particles |
| US20070020699A1 (en) * | 2005-07-19 | 2007-01-25 | Idexx Laboratories, Inc. | Lateral flow assay and device using magnetic particles |
| DE102005039175A1 (de) * | 2005-08-18 | 2007-02-22 | Qiagen Gmbh | Vorrichtung und Verfahren zum Abtrennen von magnetischen Partikeln aus einer Flüssigkeit |
| ES2692380T3 (es) | 2006-03-24 | 2018-12-03 | Handylab, Inc. | Método para realizar PCR con un cartucho con varias pistas |
| US7998708B2 (en) * | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US11806718B2 (en) | 2006-03-24 | 2023-11-07 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US10900066B2 (en) | 2006-03-24 | 2021-01-26 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US8883490B2 (en) | 2006-03-24 | 2014-11-11 | Handylab, Inc. | Fluorescence detector for microfluidic diagnostic system |
| US8088616B2 (en) | 2006-03-24 | 2012-01-03 | Handylab, Inc. | Heater unit for microfluidic diagnostic system |
| EP1839756A1 (en) * | 2006-03-31 | 2007-10-03 | F.Hoffmann-La Roche Ag | Apparatus for separating magnetic particles from liquids containing said particles, and an array of vessels suitable for use with such an apparatus |
| US8765076B2 (en) | 2006-11-14 | 2014-07-01 | Handylab, Inc. | Microfluidic valve and method of making same |
| US9618139B2 (en) | 2007-07-13 | 2017-04-11 | Handylab, Inc. | Integrated heater and magnetic separator |
| US9186677B2 (en) | 2007-07-13 | 2015-11-17 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| USD621060S1 (en) | 2008-07-14 | 2010-08-03 | Handylab, Inc. | Microfluidic cartridge |
| ES2648798T3 (es) | 2007-07-13 | 2018-01-08 | Handylab, Inc. | Materiales de captura de polinucleótidos y métodos de utilización de los mismos |
| US20090136385A1 (en) | 2007-07-13 | 2009-05-28 | Handylab, Inc. | Reagent Tube |
| US8182763B2 (en) | 2007-07-13 | 2012-05-22 | Handylab, Inc. | Rack for sample tubes and reagent holders |
| US8287820B2 (en) | 2007-07-13 | 2012-10-16 | Handylab, Inc. | Automated pipetting apparatus having a combined liquid pump and pipette head system |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| US8105783B2 (en) | 2007-07-13 | 2012-01-31 | Handylab, Inc. | Microfluidic cartridge |
| US20090027998A1 (en) * | 2007-07-25 | 2009-01-29 | Abbott Laboratories | Magnetic mixer |
| USD618820S1 (en) | 2008-07-11 | 2010-06-29 | Handylab, Inc. | Reagent holder |
| USD787087S1 (en) | 2008-07-14 | 2017-05-16 | Handylab, Inc. | Housing |
| TWI429475B (zh) * | 2009-10-30 | 2014-03-11 | Rbc Bioscience Corp | 一體式反應匣 |
| US8784734B2 (en) | 2010-05-20 | 2014-07-22 | Abbott Laboratories | Reusable sheaths for separating magnetic particles |
| EP2754496A3 (en) * | 2010-07-23 | 2017-08-02 | Beckman Coulter, Inc. | System Or Method Of Including Analytical Units |
| CA3082652A1 (en) | 2011-04-15 | 2012-10-18 | Becton, Dickinson And Company | Scanning real-time microfluidic thermocycler and methods for synchronized thermocycling and scanning optical detection |
| CN103959070B (zh) | 2011-09-30 | 2017-05-10 | 贝克顿·迪金森公司 | 组合试剂条 |
| USD692162S1 (en) | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| CN104040238B (zh) | 2011-11-04 | 2017-06-27 | 汉迪拉布公司 | 多核苷酸样品制备装置 |
| ES2978107T3 (es) | 2012-02-03 | 2024-09-05 | Becton Dickinson Co | Archivos externos para distribución de pruebas de diagnóstico molecular y determinación de compatibilidad entre pruebas |
| JP2014093988A (ja) * | 2012-11-12 | 2014-05-22 | Seiko Epson Corp | 固相担体の操作方法及び固相担体の操作装置 |
| JP2014176302A (ja) * | 2013-03-13 | 2014-09-25 | Seiko Epson Corp | 核酸増幅反応装置及び核酸増幅方法 |
| CN103861735B (zh) * | 2014-03-19 | 2017-01-25 | 东南大学 | 一种磁分离装置 |
| EP3157658B1 (en) * | 2014-06-18 | 2021-10-13 | Luminex Corporation | Apparatus for magnetic mixing |
| WO2016043291A1 (ja) * | 2014-09-19 | 2016-03-24 | 協和メデックス株式会社 | 磁性担体粒子の洗浄方法、磁性担体粒子の洗浄装置、及び磁性担体粒子を用いる免疫学的測定方法 |
| KR101583017B1 (ko) * | 2015-07-17 | 2016-01-06 | 주식회사 지노바이오 | MIP(Magnetic Iron Particles)분리 시스템 |
| KR101720609B1 (ko) * | 2015-07-17 | 2017-03-28 | 주식회사 지노바이오 | 자기력 흐름을 이용한 MIP(Magnetic Iron Particles)분리장치 |
| JP6995090B2 (ja) * | 2019-07-11 | 2022-01-14 | 日本電子株式会社 | 自動分析装置および自動分析装置の制御方法 |
| EP3834939A1 (en) * | 2019-12-12 | 2021-06-16 | TTP plc | Sample preparation system |
| GB2622290A (en) * | 2022-01-31 | 2024-03-13 | Idex Health & Science Llc | Magnetic particle reaction system |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792113A (fr) | 1971-12-13 | 1973-05-30 | Technicon Instr | Melangeur de liquides contenant des particules magnetiques |
| US4911555A (en) * | 1989-05-04 | 1990-03-27 | The Jackson Laboratory | Magnetic stirrer for multiple samples |
| WO1993008919A1 (en) | 1991-11-08 | 1993-05-13 | Envimag B.V. | Magnetic disc separator |
| US5200071A (en) * | 1992-01-09 | 1993-04-06 | Quantum Systems International, Inc. | Translating magnetic field treatment device |
| US5670329A (en) | 1993-05-28 | 1997-09-23 | Cardiovascular Diagnostics, Inc. | Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field |
| ES2170083T3 (es) * | 1993-09-17 | 2002-08-01 | Hoffmann La Roche | Analizador con un dispositivo para la separacion de microparticulas magneticas. |
| DE4423878A1 (de) | 1994-07-07 | 1996-01-11 | Boehringer Mannheim Gmbh | Vorrichtung und Verfahren zum Abscheiden von magnetischen Mikropartikeln |
| DE4429155A1 (de) | 1994-08-17 | 1996-02-22 | Hans Schiesl | Meßanordnung und Verfahren zur Durchführung luminometrischer Reihenanalysen sowie Mehrfachküvette zur Aufnahme von Flüssigkeitsproben hierfür |
| JP3607320B2 (ja) * | 1994-09-02 | 2005-01-05 | 株式会社日立製作所 | 微粒子を用いた分析における固相の回収方法及び装置 |
| US5599501A (en) | 1994-11-10 | 1997-02-04 | Ciba Corning Diagnostics Corp. | Incubation chamber |
| EP0810905B1 (en) * | 1995-02-21 | 1998-11-04 | Iqbal W. Dr. Siddiqi | Apparatus and method for mixing and separation employing magnetic particles |
| DE19512368A1 (de) | 1995-04-01 | 1996-10-02 | Boehringer Mannheim Gmbh | System zur Freisetzung und Isolierung von Nukleinsäuren |
-
1998
- 1998-07-08 DE DE69839294T patent/DE69839294T2/de not_active Expired - Lifetime
- 1998-09-17 JP JP26345498A patent/JP4351751B2/ja not_active Expired - Fee Related
- 1998-09-29 US US09/162,663 patent/US6579453B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6579453B1 (en) | 2003-06-17 |
| JP4351751B2 (ja) | 2009-10-28 |
| DE69839294D1 (de) | 2008-05-08 |
| JPH11156231A (ja) | 1999-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |