DE69839155D1 - Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren - Google Patents
Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahrenInfo
- Publication number
- DE69839155D1 DE69839155D1 DE69839155T DE69839155T DE69839155D1 DE 69839155 D1 DE69839155 D1 DE 69839155D1 DE 69839155 T DE69839155 T DE 69839155T DE 69839155 T DE69839155 T DE 69839155T DE 69839155 D1 DE69839155 D1 DE 69839155D1
- Authority
- DE
- Germany
- Prior art keywords
- keratin
- hydrogel
- disulfide linkages
- hair
- cysteic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
- C08H1/00—Macromolecular products derived from proteins
- C08H1/06—Macromolecular products derived from proteins derived from horn, hoofs, hair, skin or leather
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0028—Polypeptides; Proteins; Degradation products thereof
- A61L26/0047—Specific proteins or polypeptides not covered by groups A61L26/0033 - A61L26/0042
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/047—Other specific proteins or polypeptides not covered by A61L31/044 - A61L31/046
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4741—Keratin; Cytokeratin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/842—Skin; hair; nails; sebaceous glands; cerumen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Materials Engineering (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Birds (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Marine Sciences & Fisheries (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Cosmetics (AREA)
- Colloid Chemistry (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US979456 | 1997-11-26 | ||
US08/979,456 US5932552A (en) | 1997-11-26 | 1997-11-26 | Keratin-based hydrogel for biomedical applications and method of production |
PCT/US1998/025265 WO1999026595A1 (en) | 1997-11-26 | 1998-11-25 | Keratin-based hydrogel for biomedical applications and method of production |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69839155D1 true DE69839155D1 (de) | 2008-04-03 |
DE69839155T2 DE69839155T2 (de) | 2009-02-26 |
Family
ID=25526898
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69839155T Expired - Lifetime DE69839155T2 (de) | 1997-11-26 | 1998-11-25 | Hydrogel auf keratin-basis für biomedizinische anwendungen und dessen herstellungsverfahren |
Country Status (5)
Country | Link |
---|---|
US (3) | US5932552A (de) |
EP (1) | EP1039873B1 (de) |
AT (1) | ATE386571T1 (de) |
DE (1) | DE69839155T2 (de) |
WO (1) | WO1999026595A1 (de) |
Families Citing this family (93)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
US6110487A (en) * | 1997-11-26 | 2000-08-29 | Keraplast Technologies Ltd. | Method of making porous keratin scaffolds and products of same |
US5932552A (en) | 1997-11-26 | 1999-08-03 | Keraplast Technologies Ltd. | Keratin-based hydrogel for biomedical applications and method of production |
US6746485B1 (en) | 1999-02-18 | 2004-06-08 | St. Francis Medical Technologies, Inc. | Hair used as a biologic disk, replacement, and/or structure and method |
US6461628B1 (en) | 1999-09-13 | 2002-10-08 | Keraplast Technologies, Ltd. | Non-woven keratin cell scaffold |
US6783546B2 (en) | 1999-09-13 | 2004-08-31 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6270793B1 (en) | 1999-09-13 | 2001-08-07 | Keraplast Technologies, Ltd. | Absorbent keratin wound dressing |
US6316598B1 (en) | 1999-09-13 | 2001-11-13 | Keraplast Technologies, Ltd. | Water absorbent keratin and gel formed therefrom |
US6371984B1 (en) * | 1999-09-13 | 2002-04-16 | Keraplast Technologies, Ltd. | Implantable prosthetic or tissue expanding device |
US6544548B1 (en) * | 1999-09-13 | 2003-04-08 | Keraplast Technologies, Ltd. | Keratin-based powders and hydrogel for pharmaceutical applications |
US6749865B2 (en) | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
JP2003522806A (ja) | 2000-02-15 | 2003-07-29 | ジェンザイム、コーポレーション | 改良された薬物送達のための生体高分子の修飾 |
US6740093B2 (en) | 2000-02-28 | 2004-05-25 | Stephen Hochschuler | Method and apparatus for treating a vertebral body |
US6649740B1 (en) * | 2000-03-01 | 2003-11-18 | Keraplast Technologies, Ltd. | Hydratable form of keratin for use as a soil amendment |
JP4426841B2 (ja) | 2001-08-06 | 2010-03-03 | サウスウェスト リサーチ インスティテュート | 触媒コンバータの耐久性を試験する方法及び装置 |
MXPA04001903A (es) | 2001-08-31 | 2005-03-07 | Keratec Ltd | Produccion de pelicula, fibra o materiales adhesivos de biopolimero a partir de derivados de queratina s-sulfonados solubles. |
US7001988B2 (en) * | 2001-09-25 | 2006-02-21 | Keraplast Technologies, Ltd. | Methods for controlling peptide solubility, chemically modified peptides, and stable solvent systems for producing same |
US7921999B1 (en) | 2001-12-20 | 2011-04-12 | Watson Laboratories, Inc. | Peelable pouch for transdermal patch and method for packaging |
US7630403B2 (en) * | 2002-03-08 | 2009-12-08 | Texas Instruments Incorporated | MAC aggregation frame with MSDU and fragment of MSDU |
US20040120910A1 (en) * | 2002-04-10 | 2004-06-24 | Dyke Mark Van | Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks |
WO2003087156A2 (en) * | 2002-04-10 | 2003-10-23 | Keraplast Technologies, Ltd. | Heterogeneous crosslinked protein networks and methods for producing them |
US7001987B2 (en) * | 2002-04-22 | 2006-02-21 | Keraplast Technologies, Ltd. | Hydrogel with controllable mechanical, chemical, and biological properties and method for making same |
US6914126B2 (en) * | 2002-04-10 | 2005-07-05 | Keraplast Technologies, Ltd. | Methods for producing, films comprising, and methods for using heterogenous crosslinked protein networks |
US6989437B2 (en) * | 2002-04-10 | 2006-01-24 | Keraplast Technologies, Ltd. | Methods for producing, films comprising, and methods for using heterogeneous crosslinked protein networks |
US7892185B2 (en) * | 2002-04-19 | 2011-02-22 | Pelikan Technologies, Inc. | Method and apparatus for body fluid sampling and analyte sensing |
WO2003103737A1 (en) * | 2002-06-10 | 2003-12-18 | Wool Research Organisaton Of New Zealand (Inc) | Orthopaedic materials derived from keratin |
US20040082717A1 (en) * | 2002-06-24 | 2004-04-29 | Southwest Research Institute | Keratin-silicone copolymers and interpenetrating networks (IPN's), methods of production and methods of use thereof |
WO2004000915A2 (en) | 2002-06-24 | 2003-12-31 | Tufts University | Silk biomaterials and methods of use thereof |
US20040062793A1 (en) * | 2002-07-05 | 2004-04-01 | Dyke Mark Van | Tissue defect dressings comprising proteinaceous networks |
US7163321B2 (en) * | 2002-07-25 | 2007-01-16 | Steven Contarino | Emergency vehicle grille |
KR100984627B1 (ko) * | 2002-08-15 | 2010-09-30 | 신세스 게엠바하 | 추간 원판 임플란트 |
CA2495373C (en) | 2002-08-15 | 2012-07-24 | David Gerber | Controlled artificial intervertebral disc implant |
JP4176768B2 (ja) * | 2002-11-28 | 2008-11-05 | ケラテク リミテッド | ケラチンを含むパーソナルケア配合物 |
EP1613796B1 (de) | 2003-04-10 | 2017-03-22 | Tufts University | Konzentrierte wässrige seidenfibroinlösung und deren verwendung |
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US20050214376A1 (en) * | 2003-10-21 | 2005-09-29 | Marie-Pierre Faure | Hydrogel-containing medical articles and methods of using and making the same |
BR0304083A (pt) * | 2003-10-31 | 2005-06-28 | Maria De Lourdes M Velly | Processo de obtenção e beneficiamento do gel, da lâmina, do pó e das soluções produzidas do material protéico da rã, queratina em filme ou não e colágenos do tipo 2,4 e 6; processo de transformação deste material protéicos em gel, em lâmina, em pó, em soluções; uso do gel, uso do pó, uso da lâmina, uso das soluções, uso das aplicações destes produtos e destes materiais em formulações, uso das transformações destes produtos e destes materiais protéicos da rã |
EA011388B1 (ru) * | 2003-12-19 | 2009-02-27 | Кератек Лимитед | Продукты для ухода за ранами, содержащие кератин |
CN1315916C (zh) * | 2004-05-27 | 2007-05-16 | 四川省宜宾五粮液集团有限公司 | 动物毛角蛋白原液的制备方法及其应用 |
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EP1809636A1 (de) * | 2004-10-19 | 2007-07-25 | Arqule, Inc. | Synthese aus imidazooxazol- und imidazothiazol-hemmern der p38-map-kinase |
US7579317B2 (en) * | 2005-03-11 | 2009-08-25 | Keratec, Ltd. | Nutraceutical composition comprising soluble keratin or derivative thereof |
KR101365712B1 (ko) * | 2005-03-21 | 2014-02-24 | 시타코트 에이비 | 스페이서 분자를 경유하는 s―s 가교를 통한 결합에 의하여 기질에 공유 결합된 시스테인 성분을 포함하는 항미생물제 |
EP1888099B1 (de) | 2005-05-06 | 2014-03-26 | Keraplast Technologies Ltd. | Hydrierbare Keratin-Zusammensetzungen |
US8920827B2 (en) * | 2005-10-21 | 2014-12-30 | Wake Forest University Health Sciences | Keratin bioceramic compositions |
EP1991253B1 (de) * | 2006-02-10 | 2013-07-31 | Wake Forest University Health Sciences | Nervenregenerierung mit keratinbiomaterial |
EP1983927B1 (de) * | 2006-02-17 | 2014-11-05 | Wake Forest University Health Sciences | Beschichtungen und biomedizinische implantate aus keratinbiomaterialien |
US8273702B2 (en) | 2006-02-17 | 2012-09-25 | Wake Forest University Health Sciences | Wound healing compositions containing keratin biomaterials |
WO2008118133A2 (en) | 2006-09-26 | 2008-10-02 | Trustees Of Tufts College | Silk microspheres for encapsulation and controlled release |
WO2008070091A1 (en) * | 2006-12-06 | 2008-06-12 | Keratec, Ltd. | Bone void fillers and methods of making the same |
US8124735B2 (en) * | 2006-12-11 | 2012-02-28 | Keraplast Technologies, Ltd. | Porous keratin construct and method of making the same |
KR100841742B1 (ko) * | 2006-12-14 | 2008-06-27 | 화인코주식회사 | 하이드로겔 마스크 팩, 이의 제조 방법 및 이의 제조에이용되는 조성물 |
EP2129772B1 (de) | 2007-02-27 | 2016-07-27 | Trustees Of Tufts College | Gewebegezüchtete seidenorgane |
WO2008148109A1 (en) * | 2007-05-24 | 2008-12-04 | Keratec, Ltd. | Porous keratin constructs, wound healing assemblies and methods using the same |
US20090047260A1 (en) * | 2007-08-17 | 2009-02-19 | Wake Forest University Health Sciences | Keratin biomaterials for cell culture and methods of use |
DE102008053114B4 (de) * | 2008-10-26 | 2011-05-05 | Technische Universität Braunschweig | Pharmazeutischer Keratinschwamm |
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CA2786400C (en) * | 2010-01-05 | 2018-11-27 | Cell Constructs, Inc. | Biomaterials made from human hair |
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US10335519B2 (en) | 2011-04-20 | 2019-07-02 | Trustees Of Tufts College | Dynamic silk coatings for implantable devices |
WO2013025928A2 (en) | 2011-08-17 | 2013-02-21 | Keranetics Llc | Methods for extracting keratin proteins |
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AU2013245785A1 (en) | 2012-04-13 | 2014-10-23 | Trustees Of Tufts College | Methods and compositions for preparing a silk microsphere |
WO2014012101A1 (en) | 2012-07-13 | 2014-01-16 | Trustees Of Tufts College | Silk powder compaction for production of constructs with high mechanical strength and stiffness |
US9827245B2 (en) * | 2013-03-15 | 2017-11-28 | KeraNetics, LLC | Keratin compositions comprising halofuginone |
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-
1997
- 1997-11-26 US US08/979,456 patent/US5932552A/en not_active Expired - Lifetime
-
1998
- 1998-11-25 DE DE69839155T patent/DE69839155T2/de not_active Expired - Lifetime
- 1998-11-25 AT AT98958709T patent/ATE386571T1/de not_active IP Right Cessation
- 1998-11-25 EP EP98958709A patent/EP1039873B1/de not_active Expired - Lifetime
- 1998-11-25 WO PCT/US1998/025265 patent/WO1999026595A1/en active IP Right Grant
-
1999
- 1999-08-02 US US09/365,699 patent/US6159496A/en not_active Expired - Lifetime
-
2000
- 2000-12-12 US US09/736,957 patent/US6379690B2/en not_active Expired - Lifetime
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EP1039873B1 (de) | 2008-02-20 |
DE69839155T2 (de) | 2009-02-26 |
US6379690B2 (en) | 2002-04-30 |
US20010009675A1 (en) | 2001-07-26 |
US5932552A (en) | 1999-08-03 |
EP1039873A4 (de) | 2003-07-30 |
EP1039873A1 (de) | 2000-10-04 |
WO1999026595A1 (en) | 1999-06-03 |
ATE386571T1 (de) | 2008-03-15 |
US6159496A (en) | 2000-12-12 |
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